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Des Moines

$312+ Cheap flights from Knoxville to Des Moines (TYS - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Knoxville to Des Moines

Cheapest flights from Knoxville to Des Moines
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/202:53 pmTYS - DSM
1 stop9h 39mAllegiant Air
Tue 12/237:30 amDSM - TYS
1 stop28h 32mAllegiant Air
Deal found 12/10$312
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:03 pmTYS - DSM
1 stop21h 28mAllegiant Air
Sun 12/212:56 pmDSM - TYS
1 stop18h 35mAllegiant Air
Deal found 12/10$350
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:00 amTYS - DSM
1 stop7h 21mAmerican Airlines
Tue 12/306:52 pmDSM - TYS
1 stop14h 58mAmerican Airlines
Deal found 12/11$393
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/202:53 pmTYS - DSM
1 stop9h 39mMultiple Airlines
Tue 12/233:45 pmDSM - TYS
2 stops30h 06mMultiple Airlines
Deal found 12/10$395
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:30 amTYS - DSM
1 stop5h 51mAmerican Airlines
Mon 12/296:52 pmDSM - TYS
1 stop14h 58mAmerican Airlines
Deal found 12/9$408
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:00 amTYS - DSM
2 stops8h 26mAmerican Airlines
Sun 12/215:50 amDSM - TYS
1 stop4h 00mAmerican Airlines
Deal found 12/10$434
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:00 amTYS - DSM
1 stop4h 29mUnited Airlines
Mon 12/153:17 pmDSM - TYS
1 stop4h 47mUnited Airlines
Deal found 12/10$459
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:18 pmTYS - DSM
1 stop5h 41mAmerican Airlines
Mon 12/155:40 amDSM - TYS
2 stops7h 20mAmerican Airlines
Deal found 12/10$464
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:00 amTYS - DSM
1 stop7h 21mAmerican Airlines
Sun 12/286:52 pmDSM - TYS
1 stop14h 58mAmerican Airlines
Deal found 12/10$491
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:08 pmTYS - DSM
1 stop16h 07mAmerican Airlines
Tue 12/306:52 pmDSM - TYS
1 stop14h 58mAmerican Airlines
Deal found 12/11$505

Find flight deals from Knoxville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$393
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$407
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Des Moines
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($88 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($36 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Knoxville

Fly to

Des Moines

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 12/26

7:00 am-1:21 pm

1 stop7h 21m

Des Moines

Tue 12/30

6:52 pm-10:50 am

1 stop14h 58m

$393

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 12/25

8:30 am-1:21 pm

1 stop5h 51m

Des Moines

Mon 12/29

6:52 pm-10:50 am

1 stop14h 58m

$408

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 12/26

7:00 am-1:21 pm

1 stop7h 21m

Des Moines

Sun 12/28

6:52 pm-10:50 am

1 stop14h 58m

$491

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sat 12/27

5:08 pm-8:15 am

1 stop16h 07m

Des Moines

Tue 12/30

6:52 pm-10:50 am

1 stop14h 58m

$505

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 12/26

6:45 am-6:05 pm

1 stop12h 20m

Des Moines

Tue 12/30

6:46 pm-10:17 am

1 stop14h 31m

$547

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 3/10

11:55 am-7:27 pm

1 stop8h 32m

Des Moines

Fri 3/13

7:30 am-4:12 pm

1 stop7h 42m

$713

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Compare providers for flights from Knoxville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Des Moines in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Des Moines

What is the cheapest month to book a flight from Knoxville to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $207). Flying from Knoxville to Des Moines in March is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DSM?

Find hourly flight availability from Knoxville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

When flying from Knoxville to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 15% versus a flight at noon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 12, 2025.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Crew

8.5

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Des Moines?

    A quick flight from Knoxville to Des Moines can take about 7h 21m. American Airlines provides one of the quickest options available for as low as $393. The distance from Knoxville to Des Moines is about 654 mi.

  • What are the cheapest airlines flying from Knoxville to Des Moines round-trip?

    Cheapflights users have booked flights from Knoxville to Des Moines round-trip from $248. Another airline that can offer you cheap pricing is American Airlines. Users have found that Delta is 32% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Knoxville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Des Moines.

  • Can I find deals for business class flights from Knoxville to Des Moines?

    Yes. Cheapflights offers flight deals from Knoxville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $207). Flying from Knoxville to Des Moines in March is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Des Moines

Discover the top 2 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$283FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$343FlexibilityNo cancel feeOn-time71%

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