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Des Moines

$155+ Cheap flights from Knoxville to Des Moines (TYS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from Knoxville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated junio 12, 2025.

Round-trip from

$226
(Mytrip)

One-way from

$155
(Delta)

Popular in

March

Cheapest in

August

Average price

$402
From Knoxville McGhee Tyson to Des Moines
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One-way flight from Knoxville McGhee Tyson to Des Moines
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Highest demand for flights based on searches. 18% potential increase in price ($82 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Knoxville to Des Moines

Cheapest flights from Knoxville to Des Moines
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/99:48 pmTYS - DSM
1 stop22h 16mAllegiant Air
lun. 7/145:04 pmDSM - TYS
1 stop23h 55mAllegiant Air
Deal found 6/11$226
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/246:19 pmTYS - DSM
1 stop5h 14mDelta
mié. 7/3011:24 amDSM - TYS
1 stop5h 00mDelta
Deal found 6/10$249
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/99:48 pmTYS - DSM
1 stop22h 16mMultiple Airlines
mié. 7/1611:00 amDSM - TYS
2 stops32h 04mMultiple Airlines
Deal found 6/11$258
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/257:53 pmTYS - DSM
1 stop4h 06mAmerican Airlines
dom. 6/291:17 pmDSM - TYS
1 stop6h 42mAmerican Airlines
Deal found 6/10$259
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/245:46 pmTYS - DSM
1 stop5h 01mUnited Airlines
mié. 7/303:38 pmDSM - TYS
2 stops7h 21mUnited Airlines
Deal found 6/11$394

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Knoxville

Fly to

Des Moines

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mié. 7/9

9:48 pm-7:04 pm

1 stop22h 16m

Des Moines

lun. 7/14

5:04 pm-5:59 pm

1 stop23h 55m

$226

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 7/24

6:19 pm-10:33 pm

1 stop5h 14m

Des Moines

mié. 7/30

11:24 am-5:24 pm

1 stop5h 00m

$249

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mié. 7/9

9:48 pm-7:04 pm

1 stop22h 16m

Des Moines

mié. 7/16

11:00 am-8:04 pm

2 stops32h 04m

$258

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

mié. 6/25

7:53 pm-10:59 pm

1 stop4h 06m

Des Moines

dom. 6/29

1:17 pm-8:59 pm

1 stop6h 42m

$259

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 7/24

5:46 pm-9:47 pm

1 stop5h 01m

Des Moines

mié. 7/30

3:38 pm-11:59 pm

2 stops7h 21m

$394

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

dom. 8/17

6:14 pm-10:39 pm

1 stop5h 25m

$155

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

dom. 8/17

3:22 pm-5:48 pm

2 stops27h 26m

$165

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

dom. 8/17

3:04 pm-5:48 pm

3 stops27h 44m

$202

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Knoxville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Des Moines

What is the cheapest month to book a flight from Knoxville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $336). Flying from Knoxville to Des Moines in June is currently the most expensive (average of $411). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DSM?

Find hourly flight availability from Knoxville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

When flying from Knoxville to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 6% versus a flight in the afternoon.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated junio 12, 2025.
To help decide which airline to fly from Knoxville to Des Moines, see what other customers have to say about Delta, United Airlines and Allegiant Air. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.3
Good
725 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Des Moines round-trip?

    Cheapflights users have booked flights from Knoxville to Des Moines round-trip from $226. Other airlines that can offer you cheap pricing are Delta, from $249, and American Airlines, from $259. Users have found that Allegiant Air is 37% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Knoxville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Des Moines.

  • Can I find deals for business class flights from Knoxville to Des Moines?

    Yes. Cheapflights offers flight deals from Knoxville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $336). Flying from Knoxville to Des Moines in June is currently the most expensive (average of $411). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Top 3 airlines flying from Knoxville to Des Moines

Discover the top 3 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$222Average$283FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$338FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$252Average$407FlexibilityNo cancel feeOn-time69%

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