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Des Moines

$97+ Cheap flights from Knoxville to Des Moines (TYS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Apr 13 — Apr 201
Mon 4/13
Mon 4/20
1 adult, Economy
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Cheap flight deals from Knoxville to Des Moines

Cheapest flights from Knoxville to Des Moines
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2026.

This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:15 pm
TYS
-
DSM
1 stop6h 28m
United Airlines
Wed 4/153:21 pm
DSM
-
TYS
1 stop6h 47m
United Airlines
Deal found 3/11$279
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:00 am
TYS
-
DSM
2 stops7h 30m
American Airlines
Wed 4/152:16 pm
DSM
-
TYS
1 stop6h 05m
American Airlines
Deal found 3/11$304
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
TYS
-
DSM
1 stop8h 46m
Allegiant Air
Thu 4/168:30 am
DSM
-
TYS
1 stop11h 12m
Allegiant Air
Deal found 3/12$334
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:54 pm
TYS
-
DSM
1 stop6h 05m
American Airlines
Sun 4/126:00 am
DSM
-
TYS
1 stop4h 18m
American Airlines
Deal found 3/9$337
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:05 am
TYS
-
DSM
2 stops8h 00m
Southwest
Wed 4/155:30 am
DSM
-
TYS
2 stops13h 10m
Southwest
Deal found 3/11$340
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:00 am
TYS
-
DSM
1 stop7h 29m
Allegiant Air
Mon 3/302:15 pm
DSM
-
TYS
1 stop7h 36m
Allegiant Air
Deal found 3/11$347
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:30 pm
TYS
-
DSM
1 stop8h 12m
United Airlines
Mon 4/63:21 pm
DSM
-
TYS
1 stop6h 13m
United Airlines
Deal found 3/9$354
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:43 am
TYS
-
DSM
1 stop7h 25m
American Airlines
Sat 10/106:00 am
DSM
-
TYS
1 stop8h 10m
American Airlines
Deal found 3/11$367
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/118:30 am
TYS
-
DSM
1 stop8h 45m
United Airlines
Mon 4/133:21 pm
DSM
-
TYS
1 stop6h 13m
United Airlines
Deal found 3/8$375
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2511:30 am
TYS
-
DSM
2 stops34h 13m
Multiple Airlines
Sun 3/296:30 am
DSM
-
TYS
1 stop24h 38m
Multiple Airlines
Deal found 3/10$378
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:31 pm
TYS
-
DSM
1 stop6h 11m
American Airlines
Sat 3/2811:26 am
DSM
-
TYS
1 stop5h 05m
American Airlines
Deal found 3/9$379

Find flight deals from Knoxville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(United Airlines)

One-way from

$97
(Kiwi.com)

Popular in

October

Cheapest in

February

Average price

$318
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
Search Deals
From Knoxville McGhee Tyson to Des Moines
Search Deals
One-way flight from Knoxville McGhee Tyson to Des Moines
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($3 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/8

5:15 pm-10:43 pm

1 stop6h 28m

Des Moines

Wed 4/15

3:21 pm-11:08 pm

1 stop6h 47m

$279

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 4/8

5:00 am-11:30 am

2 stops7h 30m

Des Moines

Wed 4/15

2:16 pm-9:21 pm

1 stop6h 05m

$304

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 4/9

6:00 am-1:46 pm

1 stop8h 46m

Des Moines

Thu 4/16

8:30 am-8:42 pm

1 stop11h 12m

$334
Quickest round-trip

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 4/10

6:54 pm-11:59 pm

1 stop6h 05m

Des Moines

Sun 4/12

6:00 am-11:18 am

1 stop4h 18m

$337

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sat 4/11

11:40 am-8:34 pm

2 stops9h 54m

Des Moines

Mon 4/13

3:21 pm-10:34 pm

1 stop6h 13m

$380

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 3/25

11:30 am-1:29 pm

1 stop26h 59m

Des Moines

Sun 3/29

6:30 am-8:08 am

1 stop24h 38m

$389

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 4/9

11:27 am-9:33 am

2 stops23h 06m

Des Moines

Thu 4/16

8:30 am-8:42 pm

1 stop11h 12m

$402
Cheapest one-way

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 6/4

3:47 pm-9:27 pm

1 stop6h 40m

$97

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sat 6/27

6:30 am-10:27 am

1 stop4h 57m

$179

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 6/4

12:35 pm-11:20 pm

2 stops11h 45m

$190

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Des Moines in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Des Moines

What is the cheapest month to book a flight from Knoxville to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $207). Flying from Knoxville to Des Moines in January is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated March 14, 2026.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,291 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,291 reviews
Delta
7.9
Good
8,291 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,464 reviews
Delta
7.9
Good
8,291 reviews

Food

7.2

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Des Moines?

    A quick flight from Knoxville to Des Moines can take about 6h 28m. United Airlines provides one of the quickest options available for as low as $279. The distance from Knoxville to Des Moines is about 654 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Des Moines round-trip?

    Cheapflights users have booked flights from Knoxville to Des Moines round-trip from $248. Another airline that can offer you cheap pricing is Delta. Users have found that American Airlines is 25% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Knoxville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Des Moines.

  • Can I find deals for business class flights from Knoxville to Des Moines?

    Yes. Cheapflights offers flight deals from Knoxville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $207). Flying from Knoxville to Des Moines in January is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Des Moines

Discover the top 2 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$387FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$338FlexibilityNo cancel feeOn-timeN/A

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