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Des Moines

$117+ Cheap flights from Knoxville to Des Moines (TYS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Knoxville to Des Moines

Cheapest flights from Knoxville to Des Moines
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/124:32 pmTYS - DSM
1 stop18h 28mAllegiant Air
Sun 11/162:51 pmDSM - TYS
1 stop17h 34mAllegiant Air
Deal found 10/28$260
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/310:50 amTYS - DSM
1 stop4h 30mUnited Airlines
Sat 12/611:35 amDSM - TYS
1 stop4h 36mUnited Airlines
Deal found 10/28$271
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/38:05 amTYS - DSM
1 stop7h 28mAmerican Airlines
Sat 12/65:35 amDSM - TYS
2 stops7h 54mAmerican Airlines
Deal found 10/28$276
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/124:32 pmTYS - DSM
2 stops28h 41mMultiple Airlines
Sun 11/162:51 pmDSM - TYS
1 stop17h 34mMultiple Airlines
Deal found 10/28$283
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:26 pmTYS - DSM
1 stop28h 18mFrontier
Mon 12/298:29 pmDSM - TYS
1 stop18h 22mFrontier
Deal found 10/28$288
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:26 pmTYS - DSM
1 stop28h 18mMultiple Airlines
Tue 12/302:35 pmDSM - TYS
1 stop29h 04mMultiple Airlines
Deal found 10/28$296
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:35 amTYS - DSM
1 stop6h 07mDelta
Mon 11/246:32 pmDSM - TYS
1 stop4h 09mDelta
Deal found 10/26$310
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/219:25 pmTYS - DSM
1 stop18h 00mMultiple Airlines
Mon 11/249:34 amDSM - TYS
2 stops12h 18mMultiple Airlines
Deal found 10/26$312
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:35 amTYS - DSM
1 stop4h 45mDelta
Tue 11/187:46 amDSM - TYS
1 stop8h 00mDelta
Deal found 10/26$334
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/118:26 amTYS - DSM
1 stop4h 48mUnited Airlines
Sat 11/152:52 pmDSM - TYS
1 stop7h 52mUnited Airlines
Deal found 10/27$339
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:26 pmTYS - DSM
1 stop28h 18mMultiple Airlines
Mon 12/298:29 pmDSM - TYS
2 stops14h 33mMultiple Airlines
Deal found 10/28$343
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/54:32 pmTYS - DSM
1 stop18h 28mAllegiant Air
Fri 11/78:00 amDSM - TYS
1 stop28h 01mAllegiant Air
Deal found 10/27$344

Cheap flight deals from Knoxville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$260
(Kiwi.com)

One-way from

$117
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$421
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
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From Knoxville McGhee Tyson to Des Moines
Search Deals
One-way flight from Knoxville McGhee Tyson to Des Moines
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($75 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Knoxville

Fly to

Des Moines

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 12/3

10:50 am-2:20 pm

1 stop4h 30m

Des Moines

Sat 12/6

11:35 am-5:11 pm

1 stop4h 36m

$271

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 12/3

8:05 am-2:33 pm

1 stop7h 28m

Des Moines

Sat 12/6

5:35 am-2:29 pm

2 stops7h 54m

$276

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 11/21

5:35 am-10:42 am

1 stop6h 07m

Des Moines

Mon 11/24

6:32 pm-11:41 pm

1 stop4h 09m

$310

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 11/21

9:25 pm-2:25 pm

1 stop18h 00m

Des Moines

Mon 11/24

9:34 am-10:52 pm

2 stops12h 18m

$312

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 11/14

4:27 pm-10:59 pm

1 stop7h 32m

Des Moines

Tue 11/18

4:02 pm-9:24 pm

1 stop4h 22m

$334

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 11/14

6:35 am-10:20 am

1 stop4h 45m

Des Moines

Mon 11/17

2:17 pm-8:06 pm

1 stop4h 49m

$334

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 11/14

5:10 am-10:40 am

1 stop6h 30m

Des Moines

Mon 11/17

3:18 pm-10:51 pm

1 stop6h 33m

$334

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 11/14

6:35 am-10:20 am

1 stop4h 45m

Des Moines

Tue 11/18

7:46 am-4:46 pm

1 stop8h 00m

$334

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 12/18

9:25 am-6:05 pm

2 stops9h 40m

Des Moines

Mon 12/29

5:07 am-11:28 am

1 stop5h 21m

$334

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 11/11

8:26 am-12:14 pm

1 stop4h 48m

Des Moines

Sat 11/15

2:52 pm-11:44 pm

1 stop7h 52m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 14 results
1
2

Compare providers for flights from Knoxville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Des Moines in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Des Moines

What is the cheapest month to book a flight from Knoxville to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $207). Flying from Knoxville to Des Moines in March is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DSM?

Find hourly flight availability from Knoxville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

When flying from Knoxville to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 15% versus a flight at noon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 28, 2025.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Boarding

8.2

Overall

7.9

Comfort

7.9

Food

7.3

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Des Moines?

    A quick flight from Knoxville to Des Moines can take about 4h 30m. United Airlines provides one of the quickest options available for as low as $271. The distance from Knoxville to Des Moines is about 654 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Des Moines round-trip?

    Cheapflights users have booked flights from Knoxville to Des Moines round-trip from $248. Another airline that can offer you cheap pricing is American Airlines. Users have found that Delta is 32% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Knoxville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Des Moines.

  • Can I find deals for business class flights from Knoxville to Des Moines?

    Yes. Cheapflights offers flight deals from Knoxville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $207). Flying from Knoxville to Des Moines in March is currently the most expensive (average of $272). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 2 airlines flying from Knoxville to Des Moines

Discover the top 2 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$283FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$340FlexibilityNo cancel feeOn-time71%

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