How long is the flight from Knoxville to Des Moines?

A quick flight from Knoxville to Des Moines can take about 4h 33m. American Airlines provides one of the quickest options available for as low as $232. The distance from Knoxville to Des Moines is about 654 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Knoxville to Des Moines round-trip?

Cheapflights users have booked flights from Knoxville to Des Moines round-trip from $222. Other airlines that can offer you cheap pricing are American Airlines, from $248, and United Airlines, from $293. Users have found that Delta is 39% cheaper than the other options available to this destination.

What is the cheapest day to fly from Knoxville to Des Moines?

Travelers seeking maximum savings on their Knoxville to Des Moines flight should consider departing on Thursday afternoons when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the most popular airlines that fly from Knoxville to Des Moines?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Knoxville to Des Moines.

What is the cheapest day to fly round-trip from Knoxville to Des Moines?

Leaving on a Wednesday is a viable option for saving on travel. Heavily demanded days of the week can typically drive up the prices you see. Booking your travel for a less competitive day can save up to 121% on the overall cost on flights from Knoxville to Des Moines.

What is the cheapest month to fly from Knoxville to Des Moines?

September can be a great time to fly to Des Moines from Knoxville with a flight ticket averaging about $365. Cheapflights users have found deals in the month of September for as cheap as $233. The most expensive prices can be found in the month of March.

Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?

Yes. In addition to deals on Knoxville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Des Moines.

Can I find deals for business class flights from Knoxville to Des Moines?

Yes. Cheapflights offers flight deals from Knoxville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$169+ Cheap Flights from Knoxville to Des Moines

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Cheap flight deals from Knoxville to Des Moines

Round-trip from	$193 (American Airlines)
One-way from	$169 (United Airlines)
Popular in	March
Cheapest in	September
Average price	$248

From Knoxville McGhee Tyson to Des Moines

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One-way flight from Knoxville McGhee Tyson to Des Moines

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Highest demand for flights based on searches. 17% potential increase in price ($78 potential increase over avg. RT price).

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Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from Knoxville to Des Moines

Cheapest flights from Knoxville to Des Moines
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Wed 10/85:00 amTYS - DSM

1 stop6h 45mAmerican Airlines

Wed 10/155:42 pmDSM - TYS

1 stop4h 25mAmerican Airlines

Deal found 9/10

$193

Tue 12/2311:00 amTYS - DSM

1 stop4h 33mUnited Airlines

Sat 12/2711:35 amDSM - TYS

1 stop4h 25mUnited Airlines

Deal found 9/10

$232

Thu 10/99:50 pmTYS - DSM

1 stop11h 40mAllegiant Air

Thu 10/166:30 amDSM - TYS

1 stop9h 14mAllegiant Air

Deal found 9/11

$237

Fri 9/267:00 amTYS - DSM

1 stop4h 32mUnited Airlines

Tue 9/302:58 pmDSM - TYS

1 stop7h 45mUnited Airlines

Deal found 9/11

$266

Tue 10/147:43 pmTYS - DSM

1 stop4h 25mAmerican Airlines

Sun 10/195:00 amDSM - TYS

1 stop5h 44mAmerican Airlines

Deal found 9/11

$289

Thu 9/2511:00 amTYS - DSM

1 stop10h 40mAllegiant Air

Mon 9/298:00 amDSM - TYS

1 stop28h 29mAllegiant Air

Deal found 9/10

$302

Thu 12/186:09 pmTYS - DSM

1 stop6h 24mAmerican Airlines

Mon 12/293:27 pmDSM - TYS

1 stop4h 47mAmerican Airlines

Deal found 9/11

$318

Thu 9/255:55 pmTYS - DSM

2 stops21h 45mMultiple Airlines

Mon 9/298:00 amDSM - TYS

1 stop28h 29mMultiple Airlines

Deal found 9/10

$326

Wed 10/812:45 pmTYS - DSM

1 stop10h 00mMultiple Airlines

Wed 10/152:37 pmDSM - TYS

2 stops55h 39mMultiple Airlines

Deal found 9/10

$340

Best flights from Knoxville to Des Moines
Discover carefully curated flight deals from Knoxville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2025.

Wed 10/85:00 amTYS - DSM

1 stop6h 45mAmerican Airlines

Wed 10/155:42 pmDSM - TYS

1 stop4h 25mAmerican Airlines

Deal found 9/10

$193

Tue 12/2311:00 amTYS - DSM

1 stop4h 33mUnited Airlines

Sat 12/2711:35 amDSM - TYS

1 stop4h 25mUnited Airlines

Deal found 9/10

$232

Thu 10/99:50 pmTYS - DSM

1 stop11h 40mAllegiant Air

Thu 10/166:30 amDSM - TYS

1 stop9h 14mAllegiant Air

Deal found 9/11

$237

Thu 9/255:55 pmTYS - DSM

2 stops21h 45mMultiple Airlines

Mon 9/298:00 amDSM - TYS

1 stop28h 29mMultiple Airlines

Deal found 9/10

$326

Fri 9/267:00 amTYS - DSM

1 stop4h 32mUnited Airlines

Tue 9/302:58 pmDSM - TYS

1 stop7h 45mUnited Airlines

Deal found 9/11

$266

Tue 10/144:41 pmTYS - DSM

1 stop8h 18mAmerican Airlines

Mon 10/206:22 pmDSM - TYS

1 stop4h 28mAmerican Airlines

Deal found 9/11

$289

Thu 9/2511:00 amTYS - DSM

1 stop10h 40mAllegiant Air

Mon 9/298:00 amDSM - TYS

1 stop28h 29mAllegiant Air

Deal found 9/10

$302

Wed 10/812:45 pmTYS - DSM

1 stop10h 00mMultiple Airlines

Wed 10/152:37 pmDSM - TYS

2 stops55h 39mMultiple Airlines

Deal found 9/10

$340

Thu 12/186:09 pmTYS - DSM

1 stop6h 24mAmerican Airlines

Mon 12/293:27 pmDSM - TYS

1 stop4h 47mAmerican Airlines

Deal found 9/11

$318

Wed 11/2610:50 amTYS - DSM

1 stop4h 29mUnited Airlines

Sun 11/303:15 pmDSM - TYS

1 stop4h 18mUnited Airlines

Deal found 9/10

$370

Last-minute flights from Knoxville to Des Moines
Discover last-minute flight deals from Knoxville to Des Moines. Data last updated September 11, 2025 and is based on user searches.

Sat 9/135:45 amTYS - DSM

1 stop5h 55mDelta

Mon 9/156:30 pmDSM - TYS

1 stop4h 14mDelta

Deal found 9/10

$381

Sat 9/135:45 amTYS - DSM

2 stops9h 35mUnited Airlines

Mon 9/152:58 pmDSM - TYS

1 stop7h 46mUnited Airlines

Deal found 9/10

$386

Thu 9/2511:00 amTYS - DSM

1 stop10h 40mAllegiant Air

Mon 9/298:00 amDSM - TYS

1 stop28h 29mAllegiant Air

Deal found 9/10

$302

Thu 9/255:55 pmTYS - DSM

2 stops21h 45mMultiple Airlines

Mon 9/298:00 amDSM - TYS

1 stop28h 29mMultiple Airlines

Deal found 9/10

$326

Fri 9/267:00 amTYS - DSM

1 stop4h 32mUnited Airlines

Tue 9/302:58 pmDSM - TYS

1 stop7h 45mUnited Airlines

Deal found 9/11

$266

Wed 10/85:00 amTYS - DSM

1 stop6h 45mAmerican Airlines

Wed 10/155:42 pmDSM - TYS

1 stop4h 25mAmerican Airlines

Deal found 9/10

$193

Wed 10/812:45 pmTYS - DSM

1 stop10h 00mMultiple Airlines

Wed 10/152:37 pmDSM - TYS

2 stops55h 39mMultiple Airlines

Deal found 9/10

$340

Thu 10/99:50 pmTYS - DSM

1 stop11h 40mAllegiant Air

Thu 10/166:30 amDSM - TYS

1 stop9h 14mAllegiant Air

Deal found 9/11

$237

Tue 10/147:43 pmTYS - DSM

1 stop4h 25mAmerican Airlines

Sun 10/195:00 amDSM - TYS

1 stop5h 44mAmerican Airlines

Deal found 9/11

$289

One-way flights from Knoxville to Des Moines
Search for one-way flight options from Knoxville to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Sun 10/127:00 amTYS - DSM

1 stop4h 32mUnited Airlines

Deal found 9/10

$169

Sun 10/129:15 pmTYS - DSM

2 stops20h 46mMultiple Airlines

Deal found 9/10

$258

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 10/8

5:00 am-10:45 am

1 stop6h 45m

Des Moines

Wed 10/15

5:42 pm-11:07 pm

1 stop4h 25m

$193

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 12/23

11:00 am-2:33 pm

1 stop4h 33m

Des Moines

Sat 12/27

11:35 am-5:00 pm

1 stop4h 25m

$232

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 10/9

9:50 pm-8:30 am

1 stop11h 40m

Des Moines

Thu 10/16

6:30 am-4:44 pm

1 stop9h 14m

$237

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 9/26

7:00 am-10:32 am

1 stop4h 32m

Des Moines

Tue 9/30

2:58 pm-11:43 pm

1 stop7h 45m

$266

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 10/14

4:41 pm-11:59 pm

1 stop8h 18m

Des Moines

Mon 10/20

6:22 pm-11:50 pm

1 stop4h 28m

$289

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 9/25

11:00 am-8:40 pm

1 stop10h 40m

Des Moines

Mon 9/29

8:00 am-1:29 pm

1 stop28h 29m

$302

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 12/18

6:09 pm-11:33 pm

1 stop6h 24m

Des Moines

Mon 12/29

3:27 pm-9:14 pm

1 stop4h 47m

$318

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 9/25

5:55 pm-2:40 pm

2 stops21h 45m

Des Moines

Mon 9/29

8:00 am-1:29 pm

1 stop28h 29m

$326

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 10/8

12:45 pm-9:45 pm

1 stop10h 00m

Des Moines

Wed 10/15

2:37 pm-11:16 pm

2 stops55h 39m

$340

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 11/26

10:50 am-2:19 pm

1 stop4h 29m

Des Moines

Sun 11/30

3:15 pm-8:33 pm

1 stop4h 18m

$370

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 12 results

Best time to book a flight from Knoxville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Des Moines

What is the cheapest month to book a flight from Knoxville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $336). Flying from Knoxville to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DSM?

When flying from Knoxville to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 6% versus a flight in the afternoon.

Reviews of airlines servicing Des Moines

Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,960 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,937 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

How long is the flight from Knoxville to Des Moines?
A quick flight from Knoxville to Des Moines can take about 4h 33m. American Airlines provides one of the quickest options available for as low as $232. The distance from Knoxville to Des Moines is about 654 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Knoxville to Des Moines round-trip?
Cheapflights users have booked flights from Knoxville to Des Moines round-trip from $222. Other airlines that can offer you cheap pricing are American Airlines, from $248, and United Airlines, from $293. Users have found that Delta is 39% cheaper than the other options available to this destination.
Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?
Yes. In addition to deals on Knoxville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Des Moines.
Can I find deals for business class flights from Knoxville to Des Moines?
Yes. Cheapflights offers flight deals from Knoxville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Des Moines?
Currently, August is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $336). Flying from Knoxville to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Johnston

Altoona

Boone

Ames

West Des Moines

Ankeny

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Other flights to Des Moines

Top 3 airlines flying from Knoxville to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$222	Average$253	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$248	Average$341	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$293	Average$549	FlexibilityNo cancel fee	On-time69%

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$169+ Cheap flights from Knoxville to Des Moines (TYS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/12. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to Des Moines with Cheapflights

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3. Compare prices and book

Cheap flight deals from Knoxville to Des Moines

Round-trip from

One-way from

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Find flight deals from Knoxville to Des Moines

Cheapest flights from Knoxville to Des MoinesExplore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Best time to book a flight from Knoxville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Des Moines

What is the cheapest month to book a flight from Knoxville to Des Moines?

What is the cheapest time of day to fly from TYS to DSM?

Reviews of airlines servicing Des Moines

Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Knoxville to Des Moines?

What are the cheapest airlines flying from Knoxville to Des Moines round-trip?

Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?

How can I find direct flights from Knoxville to Des Moines?

Can I find deals for business class flights from Knoxville to Des Moines?

What is the cheapest month to book a flight from Knoxville to Des Moines?

Traveling to a place near Des Moines?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Knoxville to Des Moines

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Cheapest flights from Knoxville to Des Moines
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.