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Des Moines

$117+ Cheap flights from Knoxville to Des Moines (TYS - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Knoxville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$117
(FlightHub)

Popular in

March

Cheapest in

August

Average price

$318
From Knoxville McGhee Tyson to Des Moines
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One-way flight from Knoxville McGhee Tyson to Des Moines
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Highest demand for flights based on searches. 18% potential increase in price ($83 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to Des Moines

Cheapest flights from Knoxville to Des Moines
Explore the most affordable flight options available from Knoxville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2812:20 pmTYS - DSM
1 stop7h 20mAmerican Airlines
Sat 8/305:12 amDSM - TYS
1 stop7h 26mAmerican Airlines
Deal found 7/28$249
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/219:00 amTYS - DSM
1 stop14h 19mAllegiant Air
Fri 8/221:36 pmDSM - TYS
1 stop8h 36mAllegiant Air
Deal found 7/28$287
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/125:45 amTYS - DSM
2 stops9h 56mUnited Airlines
Sat 8/166:02 amDSM - TYS
1 stop8h 16mUnited Airlines
Deal found 7/28$288
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/186:14 pmTYS - DSM
1 stop5h 25mDelta
Fri 8/222:12 pmDSM - TYS
1 stop6h 54mDelta
Deal found 7/28$309
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/219:00 amTYS - DSM
1 stop14h 19mMultiple Airlines
Fri 8/224:29 pmDSM - TYS
2 stops22h 22mMultiple Airlines
Deal found 7/28$310

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Knoxville to Des Moines that are best for you.

Fly from

Knoxville

Fly to

Des Moines

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 8/28

12:20 pm-6:40 pm

1 stop7h 20m

Des Moines

Sat 8/30

5:12 am-1:38 pm

1 stop7h 26m

$249

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 8/21

9:00 am-10:19 pm

1 stop14h 19m

Des Moines

Fri 8/22

1:36 pm-11:12 pm

1 stop8h 36m

$287

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 8/12

5:45 am-2:41 pm

2 stops9h 56m

Des Moines

Sat 8/16

6:02 am-3:18 pm

1 stop8h 16m

$288

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Mon 8/18

6:14 pm-10:39 pm

1 stop5h 25m

Des Moines

Fri 8/22

2:12 pm-10:06 pm

1 stop6h 54m

$309

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 8/21

9:00 am-10:19 pm

1 stop14h 19m

Des Moines

Fri 8/22

4:29 pm-3:51 pm

2 stops22h 22m

$310

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 8/24

8:33 pm-2:23 pm

1 stop18h 50m

$117

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 8/24

9:12 pm-8:41 pm

2 stops24h 29m

$142

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Best time to book a flight from Knoxville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Des Moines

What is the cheapest month to book a flight from Knoxville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $336). Flying from Knoxville to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to DSM?

Find hourly flight availability from Knoxville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

When flying from Knoxville to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 6% versus a flight in the afternoon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 29, 2025.
Read through reviews of airlines operating flights from Knoxville to Des Moines, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,977 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,899 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
703 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,238 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Des Moines round-trip?

    Cheapflights users have booked flights from Knoxville to Des Moines round-trip from $249. Other airlines that can offer you cheap pricing are Allegiant Air, from $287, and United Airlines, from $288. Users have found that American Airlines is 30% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Knoxville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Des Moines.

  • Can I find deals for business class flights from Knoxville to Des Moines?

    Yes. Cheapflights offers flight deals from Knoxville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Des Moines (average of $336). Flying from Knoxville to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Top 3 airlines flying from Knoxville to Des Moines

Discover the top 3 airlines that operate flights from Knoxville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$222Average$277FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$332FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$293Average$549FlexibilityNo cancel feeOn-time69%

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