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Des Moines

$160+ Cheap flights from Greenville to Des Moines (GSP - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/8. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Apr 13 — Apr 201
Mon 4/13
Mon 4/20
1 adult, Economy
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Cheap flight deals from Greenville to Des Moines

Cheapest flights from Greenville to Des Moines
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2026.

This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:30 am
GSP
-
DSM
1 stop7h 50m
American Airlines
Tue 5/121:38 pm
DSM
-
GSP
1 stop6h 35m
American Airlines
Deal found 3/12$328
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/812:07 pm
GSP
-
DSM
2 stops12h 10m
United Airlines
Sat 4/116:20 am
DSM
-
GSP
1 stop4h 24m
United Airlines
Deal found 3/9$352
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:30 am
GSP
-
DSM
1 stop7h 16m
American Airlines
Fri 4/103:00 pm
DSM
-
GSP
1 stop5h 38m
American Airlines
Deal found 3/10$353
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/81:55 pm
GSP
-
DSM
2 stops9h 15m
Southwest
Fri 4/107:10 pm
DSM
-
GSP
2 stops14h 00m
Southwest
Deal found 3/10$363

Find flight deals from Greenville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$328
(American Airlines)

One-way from

$160
(United Airlines)

Popular in

March

Cheapest in

October

Average price

$786
Provider with most accurate pricing for Greenville-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Des Moines flights.
Search Deals
From Greenville to Des Moines
Search Deals
One-way flight from Greenville to Des Moines
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($140 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 5/5

6:30 am-12:55 pm

1 stop7h 25m

Des Moines

Sat 5/9

2:16 pm-7:46 pm

1 stop4h 30m

$337

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 5/5

1:55 pm-10:10 pm

2 stops9h 15m

Des Moines

Sat 5/9

6:40 am-4:35 pm

2 stops8h 55m

$347

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 4/8

12:07 pm-11:17 pm

2 stops12h 10m

Des Moines

Sat 4/11

6:20 am-11:44 am

1 stop4h 24m

$352
Quickest round-trip

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 5/7

8:45 am-1:37 pm

1 stop5h 52m

Des Moines

Sun 5/10

2:33 pm-8:13 pm

1 stop4h 40m

$371

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 5/5

4:35 pm-11:44 pm

1 stop8h 09m

Des Moines

Sat 5/9

5:30 am-2:49 pm

1 stop8h 19m

$398

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 5/22

7:32 pm-12:10 am

1 stop5h 38m

Des Moines

Mon 5/25

6:55 am-2:07 pm

1 stop6h 12m

$407

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 7/10

3:00 pm-7:55 pm

1 stop5h 55m

Des Moines

Tue 7/21

2:15 pm-8:17 pm

1 stop5h 02m

$407
Cheapest one-way
Quickest one-way

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 4/15

10:36 am-2:25 pm

1 stop4h 49m

$160

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 4/8

6:30 am-10:44 am

1 stop5h 14m

$160

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 4/8

5:05 pm-10:10 pm

2 stops6h 05m

$165

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Greenville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Des Moines in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Des Moines

What is the cheapest month to book a flight from Greenville to Des Moines?

Currently, June is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $207). Flying from Greenville to Des Moines in January is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated March 14, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Greenville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,291 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Food

7.2

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,291 reviews
Delta
7.9
Good
8,291 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Food

7.2

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,423 reviews
Delta
7.9
Good
8,291 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Food

7.2

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,464 reviews
Delta
7.9
Good
8,291 reviews

Comfort

7.9

Boarding

8.1

Overall

7.9

Food

7.2

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Des Moines?

    American Airlines can get you from Greenville to Des Moines in just under 7h 50m. Your travel time can differ by up to . The distance from Greenville to Des Moines is about 771 mi.

  • What are the cheapest airlines flying from Greenville to Des Moines round-trip?

    Currently priced at $208, Delta will fly you from Greenville to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $216 and $326, respectively. These flights start at 53% lower than the current average price 3 months from now.

  • Can I find deals for flights from Greenville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Greenville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Des Moines.

  • Can I find deals for business class flights from Greenville to Des Moines?

    Yes. Cheapflights offers flight deals from Greenville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Des Moines?

    Currently, June is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $207). Flying from Greenville to Des Moines in January is currently the most expensive (average of $308). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines

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Top 3 airlines flying from Greenville to Des Moines

Discover the top 3 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$376FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$347FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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