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Des Moines

$154+ Cheap flights from Greenville to Des Moines (GSP - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
ago. 4 — ago. 111
lun. 8/4
lun. 8/11
1 adult, Economy
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Cheap flight deals from Greenville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julio 30, 2025.

Round-trip from

$237
(Delta)

One-way from

$154
(American Airlines)

Popular in

April

Cheapest in

September

Average price

$366
From Greenville to Des Moines
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One-way flight from Greenville to Des Moines
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Highest demand for flights based on searches. 12% potential increase in price ($57 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($25 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Greenville to Des Moines

Cheapest flights from Greenville to Des Moines
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/305:30 amGSP - DSM
1 stop5h 35mDelta
dom. 11/26:39 pmDSM - GSP
1 stop4h 15mDelta
Deal found 7/28$237
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/308:04 pmGSP - DSM
1 stop4h 19mAmerican Airlines
dom. 11/24:02 pmDSM - GSP
2 stops6h 56mAmerican Airlines
Deal found 7/29$373
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/126:02 amGSP - DSM
2 stops9h 08mUnited Airlines
dom. 9/146:25 pmDSM - GSP
1 stop16h 31mUnited Airlines
Deal found 7/30$549
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/139:30 amGSP - DSM
2 stops13h 50mSouthwest
jue. 8/286:00 amDSM - GSP
2 stops11h 05mSouthwest
Deal found 7/30$560

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.

Fly from

Greenville

Fly to

Des Moines

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jue. 10/30

5:30 am-10:05 am

1 stop5h 35m

Des Moines

dom. 11/2

6:39 pm-11:54 pm

1 stop4h 15m

$237

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jue. 10/30

8:04 pm-11:23 pm

1 stop4h 19m

Des Moines

dom. 11/2

4:02 pm-11:58 pm

2 stops6h 56m

$373

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

vie. 9/12

6:02 am-2:10 pm

2 stops9h 08m

Des Moines

dom. 9/14

6:25 pm-11:56 am

1 stop16h 31m

$549

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mié. 8/13

9:30 am-10:20 pm

2 stops13h 50m

Des Moines

jue. 8/28

6:00 am-6:05 pm

2 stops11h 05m

$560

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

dom. 8/31

6:00 am-10:53 am

1 stop5h 53m

$154

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

dom. 8/31

6:02 am-2:17 pm

2 stops9h 15m

$245

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Greenville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Des Moines

What is the cheapest month to book a flight from Greenville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to DSM?

Find hourly flight availability from Greenville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 30, 2025.

It’s typically best to fly out from Greenville to Des Moines at noon. Doing so could potentially save you 39% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated julio 30, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Greenville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,896 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Greenville to Des Moines round-trip?

    Currently priced at $237, Delta will fly you from Greenville to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $373 and $549, respectively. These flights start at 39% lower than the current average price 3 months from now.

  • Can I find deals for flights from Greenville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Greenville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Des Moines.

  • Can I find deals for business class flights from Greenville to Des Moines?

    Yes. Cheapflights offers flight deals from Greenville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Top 2 airlines flying from Greenville to Des Moines

Discover the top 2 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$388FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$266Average$366FlexibilityNo cancel feeOn-time71%

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