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Des Moines

$126+ Cheap flights from Greenville to Des Moines (GSP - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Jun 19 — Jun 261
Thu 6/19
Thu 6/26
1 adult, Economy
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Cheap flight deals from Greenville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 14, 2025.

Round-trip from

$251
(Delta)

One-way from

$126
(American Airlines)

Popular in

April

Cheapest in

March

Average price

$376
From Greenville to Des Moines
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One-way flight from Greenville to Des Moines
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Highest demand for flights based on searches. 11% potential increase in price ($50 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Greenville to Des Moines

Cheapest flights from Greenville to Des Moines
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 14, 2025.

This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:45 amGSP - DSM
1 stop4h 33mDelta
Sat 9/275:45 amDSM - GSP
1 stop6h 23mDelta
Deal found 6/11$251
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/138:05 amGSP - DSM
2 stops8h 28mAmerican Airlines
Sat 9/279:34 amDSM - GSP
1 stop6h 23mAmerican Airlines
Deal found 6/11$256
This Mytrip deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/242:49 pmGSP - DSM
2 stops28h 17mAllegiant Air
Fri 8/229:05 amDSM - GSP
1 stop7h 30mAllegiant Air
Deal found 6/12$275
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/3010:25 amGSP - DSM
2 stops13h 50mSouthwest
Tue 8/56:30 amDSM - GSP
2 stops10h 35mSouthwest
Deal found 6/13$318
This Mytrip deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/254:05 pmGSP - DSM
2 stops26h 11mMultiple Airlines
Sun 7/273:45 pmDSM - GSP
1 stop22h 14mMultiple Airlines
Deal found 6/13$332
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2410:27 amGSP - DSM
2 stops12h 20mUnited Airlines
Fri 8/2211:35 amDSM - GSP
2 stops8h 26mUnited Airlines
Deal found 6/12$412

Cheapflights Fare Finder

Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 14, 2025.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.

Fly from

Greenville

Fly to

Des Moines

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 9/13

6:45 am-10:18 am

1 stop4h 33m

Des Moines

Sat 9/27

5:45 am-1:08 pm

1 stop6h 23m

$251

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 9/13

8:05 am-3:33 pm

2 stops8h 28m

Des Moines

Sat 9/27

9:34 am-4:57 pm

1 stop6h 23m

$256

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 7/24

2:49 pm-6:06 pm

2 stops28h 17m

Des Moines

Fri 8/22

9:05 am-5:35 pm

1 stop7h 30m

$275

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 7/30

10:25 am-11:15 pm

2 stops13h 50m

Des Moines

Tue 8/5

6:30 am-6:05 pm

2 stops10h 35m

$318

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 7/25

4:05 pm-5:16 pm

2 stops26h 11m

Des Moines

Sun 7/27

3:45 pm-2:59 pm

1 stop22h 14m

$332

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 6/28

5:35 pm-9:47 pm

1 stop5h 12m

Des Moines

Wed 7/2

6:24 am-2:17 pm

2 stops6h 53m

$367

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sun 8/31

7:00 am-10:53 am

1 stop4h 53m

$126

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sun 8/31

6:08 am-2:10 pm

2 stops9h 02m

$166

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/13

Best time to book a flight from Greenville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Des Moines

What is the cheapest month to book a flight from Greenville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $411). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to DSM?

Find hourly flight availability from Greenville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 14, 2025.

It’s typically best to fly out from Greenville to Des Moines at noon. Doing so could potentially save you 39% on the flight price compared to flying in the evening, which is usually more expensive.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 14, 2025.
Read through reviews of airlines operating flights from Greenville to Des Moines, such as Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,283 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.2

Food

7.1

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,283 reviews
Southwest
8.0
Very good
4,283 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.2

Food

7.1

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,958 reviews
Southwest
8.0
Very good
4,283 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.2

Food

7.1

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,793 reviews
Southwest
8.0
Very good
4,283 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.2

Food

7.1

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Allegiant Air
7.3
Good
724 reviews
Southwest
8.0
Very good
4,283 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.2

Food

7.1

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,283 reviews

Crew

8.6

Overall

8.0

Comfort

8.0

Boarding

8.2

Food

7.1

Entertainment

7.6

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Greenville to Des Moines round-trip?

    Currently priced at $251, Delta will fly you from Greenville to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Allegiant Air - these airlines can fly you to your destination from $256 and $275, respectively. These flights start at 37% lower than the current average price 3 months from now.

  • Can I find deals for flights from Greenville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Greenville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Des Moines.

  • Can I find deals for business class flights from Greenville to Des Moines?

    Yes. Cheapflights offers flight deals from Greenville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $411). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Top 2 airlines flying from Greenville to Des Moines

Discover the top 2 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$216Average$366FlexibilityNo cancel feeOn-time71%
DeltaCheapest$270Average$376FlexibilityNo cancel feeOn-timeN/A

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