HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$136+ Cheap flights from Greenville to Des Moines (GSP - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
mai 6 — mai 131
mar. 5/6
mar. 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Greenville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated mai 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$271
(Delta)

One-way from

$136
(American Airlines)

Popular in

April

Cheapest in

March

Average price

$401
Provider with most accurate pricing for Greenville-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Des Moines flights.
Search Deals
From Greenville to Des Moines
Search Deals
One-way flight from Greenville to Des Moines
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($50 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals

Find flight deals from Greenville to Des Moines

Cheapest flights from Greenville to Des Moines
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on mai 1, 2025.

This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/195:45 amGSP - DSM
1 stop5h 29mDelta
mer. 8/205:45 amDSM - GSP
1 stop6h 28mDelta
Deal found 4/30$271
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/196:40 amGSP - DSM
2 stops7h 12mAmerican Airlines
mer. 8/205:12 amDSM - GSP
1 stop5h 26mAmerican Airlines
Deal found 4/30$276
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/1910:25 amGSP - DSM
2 stops12h 00mSouthwest
mer. 8/208:25 amDSM - GSP
2 stops10h 30mSouthwest
Deal found 4/30$332
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 8/79:37 amGSP - DSM
1 stop6h 04mUnited Airlines
mer. 8/139:10 amDSM - GSP
2 stops13h 33mUnited Airlines
Deal found 4/29$362
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 5/154:33 pmGSP - DSM
2 stops24h 20mMultiple Airlines
lun. 5/197:30 amDSM - GSP
1 stop5h 46mMultiple Airlines
Deal found 4/30$411

Cheapflights Fare Finder

Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mai 1, 2025.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.

Fly from

Greenville

Fly to

Des Moines

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mar. 8/19

5:45 am-10:14 am

1 stop5h 29m

Des Moines

mer. 8/20

5:45 am-1:13 pm

1 stop6h 28m

$271

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mar. 8/19

6:40 am-12:52 pm

2 stops7h 12m

Des Moines

mer. 8/20

5:12 am-11:38 am

1 stop5h 26m

$276

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

mar. 8/19

10:25 am-9:25 pm

2 stops12h 00m

Des Moines

mer. 8/20

8:25 am-7:55 pm

2 stops10h 30m

$332

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jeu. 8/7

9:37 am-2:41 pm

1 stop6h 04m

Des Moines

mer. 8/13

9:10 am-11:43 pm

2 stops13h 33m

$362

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jeu. 5/15

4:33 pm-3:53 pm

2 stops24h 20m

Des Moines

lun. 5/19

7:30 am-2:16 pm

1 stop5h 46m

$411

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

dim. 8/31

7:25 pm-11:57 pm

1 stop5h 32m

$136

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

jeu. 6/5

5:25 am-10:41 am

1 stop6h 16m

$152

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

dim. 8/31

6:03 am-2:10 pm

2 stops9h 07m

$176

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Compare providers for flights from Greenville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Des Moines in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Des Moines

What is the cheapest month to book a flight from Greenville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to DSM?

Find hourly flight availability from Greenville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated mai 1, 2025.

It’s typically best to fly out from Greenville to Des Moines at noon. Doing so could potentially save you 39% on the flight price compared to flying in the evening, which is usually more expensive.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated mai 1, 2025.
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,294 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,934 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,294 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Food

7.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Greenville to Des Moines round-trip?

    Currently priced at $271, Delta will fly you from Greenville to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Southwest - these airlines can fly you to your destination from $276 and $332, respectively. These flights start at 33% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Greenville to Des Moines one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $136. Users have also found prices from $152 and $176 on Delta and United Airlines, respectively.

  • Can I find deals for flights from Greenville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Greenville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Des Moines.

  • Can I find deals for business class flights from Greenville to Des Moines?

    Yes. Cheapflights offers flight deals from Greenville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Des Moines flights
Charlotte to Omaha flights
Columbia to Des Moines flights
Charlotte to Cedar Rapids flights
Charleston to Cedar Rapids flights
Savannah to Des Moines flights
Charleston to Des Moines flights
Savannah to Omaha flights
Greenville to Omaha flights
Columbia to Cedar Rapids flights
Charleston to Omaha flights
Myrtle Beach to Omaha flights
Myrtle Beach to Des Moines flights
Columbia to Moline flights
Charlotte to Moline flights
Columbia to Omaha flights
Savannah to Cedar Rapids flights
Myrtle Beach to Cedar Rapids flights
Augusta to Moline flights
Greenville to Cedar Rapids flights
Charlotte to Dubuque flights
Greenville to Moline flights
Myrtle Beach to Moline flights
Augusta to Omaha flights
Savannah to Dubuque flights
Augusta to Cedar Rapids flights
Charlotte to Sioux City flights
Hilton Head Island to Moline flights
Hilton Head Island to Omaha flights
Charleston to Moline flights
Charleston to Dubuque flights
Columbia to Dubuque flights
Augusta to Des Moines flights
Savannah to Sioux City flights
Charlotte to La Crosse flights
Charlotte to Waterloo flights
Charleston to La Crosse flights

Top 2 airlines flying from Greenville to Des Moines

Discover the top 2 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mai 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$276Average$388FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$294Average$366FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.