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Des Moines

$134+ Cheap flights from Greenville to Des Moines (GSP - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Greenville to Des Moines

Cheapest flights from Greenville to Des Moines
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/63:36 pmGSP - DSM
1 stop19h 59mMultiple Airlines
Sun 11/99:03 pmDSM - GSP
2 stops21h 20mMultiple Airlines
Deal found 10/25$346
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/249:53 pmGSP - DSM
1 stop26h 31mAllegiant Air
Sun 11/308:55 amDSM - GSP
1 stop28h 25mAllegiant Air
Deal found 10/27$386
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:38 amGSP - DSM
1 stop5h 45mAmerican Airlines
Sun 12/145:30 amDSM - GSP
1 stop4h 31mAmerican Airlines
Deal found 10/26$387
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:00 amGSP - DSM
2 stops16h 35mSouthwest
Sun 12/148:00 amDSM - GSP
2 stops10h 25mSouthwest
Deal found 10/26$408
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/106:00 amGSP - DSM
1 stop5h 40mAmerican Airlines
Mon 11/105:04 pmDSM - GSP
1 stop4h 56mAmerican Airlines
Deal found 10/25$447
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/249:53 pmGSP - DSM
1 stop26h 31mMultiple Airlines
Sun 11/308:19 pmDSM - GSP
2 stops22h 04mMultiple Airlines
Deal found 10/27$482
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/611:29 amGSP - DSM
1 stop6h 23mDelta
Sun 11/95:35 amDSM - GSP
1 stop3h 52mDelta
Deal found 10/26$507
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:07 pmGSP - DSM
1 stop13h 08mAmerican Airlines
Sat 12/271:25 pmDSM - GSP
1 stop9h 04mAmerican Airlines
Deal found 10/27$521
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:12 amGSP - DSM
1 stop8h 04mAmerican Airlines
Sun 11/96:40 pmDSM - GSP
1 stop15h 18mAmerican Airlines
Deal found 10/25$539
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:20 amGSP - DSM
2 stops14h 15mSouthwest
Sun 11/95:45 amDSM - GSP
2 stops12h 40mSouthwest
Deal found 10/25$550

Cheap flight deals from Greenville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$386
(Kiwi.com)

One-way from

$134
(Kiwi.com)

Popular in

April

Cheapest in

March

Average price

$337
Provider with most accurate pricing for Greenville-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Des Moines flights.
Search Deals
From Greenville to Des Moines
Search Deals
One-way flight from Greenville to Des Moines
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.

Fly from

Greenville

Fly to

Des Moines

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 11/6

3:36 pm-10:35 am

1 stop19h 59m

Des Moines

Sun 11/9

9:03 pm-7:23 pm

2 stops21h 20m

$346

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Mon 11/24

9:53 pm-11:24 pm

1 stop26h 31m

Des Moines

Sun 11/30

8:55 am-2:20 pm

1 stop28h 25m

$386

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 12/12

7:38 am-12:23 pm

1 stop5h 45m

Des Moines

Sun 12/14

5:30 am-11:01 am

1 stop4h 31m

$387

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 12/12

8:00 am-11:35 pm

2 stops16h 35m

Des Moines

Sun 12/14

8:00 am-7:25 pm

2 stops10h 25m

$408

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Mon 11/10

6:00 am-10:40 am

1 stop5h 40m

Des Moines

Mon 11/10

5:04 pm-11:00 pm

1 stop4h 56m

$447

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Mon 11/24

9:53 pm-11:24 pm

1 stop26h 31m

Des Moines

Sun 11/30

8:19 pm-7:23 pm

2 stops22h 04m

$482

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 11/6

11:29 am-4:52 pm

1 stop6h 23m

Des Moines

Sun 11/9

5:35 am-10:27 am

1 stop3h 52m

$507

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 11/6

6:12 am-1:16 pm

1 stop8h 04m

Des Moines

Sun 11/9

6:40 pm-10:58 am

1 stop15h 18m

$539

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 11/6

10:20 am-11:35 pm

2 stops14h 15m

Des Moines

Sun 11/9

5:45 am-7:25 pm

2 stops12h 40m

$550

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sun 11/23

8:03 pm-9:09 pm

1 stop26h 06m

$134

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 20 results
1
2

Compare providers for flights from Greenville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Des Moines in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Des Moines

What is the cheapest month to book a flight from Greenville to Des Moines?

Currently, November is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $157). Flying from Greenville to Des Moines in December is currently the most expensive (average of $292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to DSM?

Find hourly flight availability from Greenville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

It’s typically best to fly out from Greenville to Des Moines at noon. Doing so could potentially save you 38% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 28, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Greenville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,996 reviews

Boarding

8.2

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,996 reviews
Delta
7.9
Good
7,996 reviews

Boarding

8.2

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,997 reviews
Delta
7.9
Good
7,996 reviews

Boarding

8.2

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,996 reviews

Boarding

8.2

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Des Moines?

    Allegiant Air, American Airlines, and Southwest can get you from Greenville to Des Moines in just under 5h 45m. Your travel time can differ by up to 20h 46m. The distance from Greenville to Des Moines is about 771 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Greenville to Des Moines round-trip?

    Currently priced at $216, Delta will fly you from Greenville to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $266 and $326, respectively. These flights start at 47% lower than the current average price 3 months from now.

  • Can I find deals for flights from Greenville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Greenville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Des Moines.

  • Can I find deals for business class flights from Greenville to Des Moines?

    Yes. Cheapflights offers flight deals from Greenville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Des Moines?

    Currently, November is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $157). Flying from Greenville to Des Moines in December is currently the most expensive (average of $292). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 3 airlines flying from Greenville to Des Moines

Discover the top 3 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$373FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$266Average$366FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$626FlexibilityNo cancel feeOn-time69%

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