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Des Moines

$110+ Cheap flights from Greenville to Des Moines (GSP - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/22. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — DSM
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Greenville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$219
(Delta)

One-way from

$110
(American Airlines)

Popular in

April

Cheapest in

March

Average price

$338
From Greenville to Des Moines
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One-way flight from Greenville to Des Moines
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Highest demand for flights based on searches. 8% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Greenville to Des Moines

Cheapest flights from Greenville to Des Moines
Explore the most affordable flight options available from Greenville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/75:30 amGSP - DSM
1 stop5h 35mDelta
Sat 10/115:15 pmDSM - GSP
1 stop5h 40mDelta
Deal found 9/11$219
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/75:00 pmGSP - DSM
1 stop6h 28mUnited Airlines
Sat 10/1111:31 amDSM - GSP
2 stops11h 15mUnited Airlines
Deal found 9/11$224
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/105:00 pmGSP - DSM
1 stop6h 28mUnited Airlines
Sat 10/1112:52 pmDSM - GSP
1 stop7h 26mUnited Airlines
Deal found 9/9$259
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:33 pmGSP - DSM
1 stop5h 40mAmerican Airlines
Sun 10/55:11 amDSM - GSP
1 stop5h 46mAmerican Airlines
Deal found 9/9$268
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/143:55 pmGSP - DSM
2 stops9h 01mUnited Airlines
Sat 10/1812:52 pmDSM - GSP
2 stops9h 54mUnited Airlines
Deal found 9/11$299
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:30 amGSP - DSM
1 stop5h 35mDelta
Sun 11/26:39 pmDSM - GSP
1 stop4h 16mDelta
Deal found 9/10$308
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/267:44 pmGSP - DSM
1 stop5h 01mAmerican Airlines
Tue 9/303:50 pmDSM - GSP
1 stop5h 10mAmerican Airlines
Deal found 9/10$333

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Greenville to Des Moines that are best for you.

Fly from

Greenville

Fly to

Des Moines

Route

Depart

Return

Price

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 10/15

5:30 am-10:05 am

1 stop5h 35m

Des Moines

Sat 10/18

5:15 pm-11:55 pm

1 stop5h 40m

$219

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 10/14

5:34 pm-9:50 pm

1 stop5h 16m

Des Moines

Sat 10/18

11:31 am-4:53 pm

1 stop4h 22m

$219

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 10/7

5:30 am-10:05 am

1 stop5h 35m

Des Moines

Sat 10/11

5:15 pm-11:55 pm

1 stop5h 40m

$219

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Wed 10/8

5:30 am-10:05 am

1 stop5h 35m

Des Moines

Sat 10/11

5:15 pm-11:55 pm

1 stop5h 40m

$219

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 10/7

10:05 am-5:24 pm

2 stops8h 19m

Des Moines

Sat 10/11

12:52 pm-11:46 pm

2 stops9h 54m

$229

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 10/10

5:00 pm-10:28 pm

1 stop6h 28m

Des Moines

Sat 10/11

12:52 pm-9:18 pm

1 stop7h 26m

$259

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 9/30

6:33 pm-11:13 pm

1 stop5h 40m

Des Moines

Sun 10/5

5:11 am-11:57 am

1 stop5h 46m

$268

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 11/6

7:38 am-12:24 pm

1 stop5h 46m

Des Moines

Mon 11/10

2:19 pm-10:00 pm

1 stop6h 41m

$299

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Fri 10/17

5:55 pm-10:56 pm

1 stop6h 01m

Des Moines

Mon 10/20

6:22 pm-11:51 pm

1 stop4h 29m

$299

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 11/22

6:00 am-10:40 am

1 stop5h 40m

$110

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 14 results
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Best time to book a flight from Greenville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Des Moines

What is the cheapest month to book a flight from Greenville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to DSM?

Find hourly flight availability from Greenville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from Greenville to Des Moines at noon. Doing so could potentially save you 39% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 11, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Greenville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Greenville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Des Moines?

    Delta and United Airlines can get you from Greenville to Des Moines in just under 5h 16m. Your travel time can differ by up to 19m. The distance from Greenville to Des Moines is about 771 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Greenville to Des Moines round-trip?

    Currently priced at $216, Delta will fly you from Greenville to Des Moines and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and United Airlines - these airlines can fly you to your destination from $266 and $366, respectively. These flights start at 47% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Greenville to Des Moines one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $110. Users have also found prices from $159 and $199 on Delta and United Airlines, respectively.

  • Can I find deals for flights from Greenville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Greenville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Des Moines.

  • Can I find deals for business class flights from Greenville to Des Moines?

    Yes. Cheapflights offers flight deals from Greenville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Des Moines (average of $336). Flying from Greenville to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 3 airlines flying from Greenville to Des Moines

Discover the top 3 airlines that operate flights from Greenville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$396FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$266Average$366FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$366Average$626FlexibilityNo cancel feeOn-time69%

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