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Des Moines

$178+ Cheap flights from Buffalo to Des Moines (BUF - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — DSM
Apr 14 — Apr 211
Tue 4/14
Tue 4/21
1 adult, Economy
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Cheap flight deals from Buffalo to Des Moines

Cheapest flights from Buffalo to Des Moines
Explore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 15, 2026.

This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:00 am
BUF
-
DSM
1 stop6h 29m
United Airlines
Tue 4/143:21 pm
DSM
-
BUF
1 stop4h 22m
United Airlines
Deal found 3/12$319
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:31 am
BUF
-
DSM
1 stop6h 00m
American Airlines
Tue 4/141:38 pm
DSM
-
BUF
1 stop8h 02m
American Airlines
Deal found 3/11$339
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:32 pm
BUF
-
DSM
1 stop5h 21m
American Airlines
Mon 4/2711:09 am
DSM
-
BUF
1 stop5h 21m
American Airlines
Deal found 3/12$381
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:10 pm
BUF
-
DSM
2 stops10h 00m
Southwest
Tue 5/265:30 am
DSM
-
BUF
1 stop3h 50m
Southwest
Deal found 3/13$386
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:02 pm
BUF
-
DSM
1 stop4h 30m
United Airlines
Wed 4/293:21 pm
DSM
-
BUF
1 stop4h 22m
United Airlines
Deal found 3/12$389
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:44 pm
BUF
-
DSM
1 stop6h 50m
Delta
Mon 4/272:44 pm
DSM
-
BUF
1 stop7h 53m
Delta
Deal found 3/11$391

Find flight deals from Buffalo to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(United Airlines)

One-way from

$178
(Southwest)

Popular in

March

Cheapest in

June

Average price

$699
Provider with most accurate pricing for Buffalo-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Des Moines flights.
Search Deals
From Buffalo to Des Moines
Search Deals
One-way flight from Buffalo to Des Moines
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($102 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($29 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 15, 2026.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 4/28

6:02 pm-9:32 pm

1 stop4h 30m

Des Moines

Wed 4/29

1:32 pm-11:10 pm

1 stop8h 38m

$389
Quickest round-trip

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 4/24

5:32 pm-9:53 pm

1 stop5h 21m

Des Moines

Mon 4/27

8:56 am-2:21 pm

1 stop4h 25m

$391

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 6/25

2:30 pm-7:55 pm

1 stop6h 25m

Des Moines

Mon 6/29

5:25 pm-11:03 pm

1 stop4h 38m

$407

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 8/18

6:00 am-11:50 am

2 stops6h 50m

Des Moines

Sat 8/22

5:30 am-10:10 am

1 stop3h 40m

$412

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 4/7

2:54 pm-11:42 pm

2 stops9h 48m

Des Moines

Tue 4/14

1:10 pm-11:33 pm

2 stops9h 23m

$417
Cheapest one-way

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Mon 5/25

6:15 am-11:08 am

1 stop5h 53m

$204

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Mon 5/18

4:00 pm-11:05 pm

2 stops8h 05m

$219
Quickest one-way

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Wed 3/25

5:29 pm-9:40 pm

1 stop5h 11m

$244

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Mon 5/25

4:00 pm-11:05 pm

2 stops8h 05m

$285

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Mon 5/25

7:52 pm-7:15 pm

3 stops48h 23m

$461

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Sorted by cheapest first

Compare providers for flights from Buffalo to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Des Moines in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated March 15, 2026.
Read through reviews of airlines operating flights from Buffalo to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,293 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,293 reviews
Delta
7.9
Good
8,293 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.1
Good
11,472 reviews
Delta
7.9
Good
8,293 reviews

Entertainment

7.8

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Des Moines?

    A quick flight from Buffalo to Des Moines can take about 4h 30m. United Airlines provides one of the quickest options available for as low as $389. The distance between Buffalo and Des Moines is about 768 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Des Moines round-trip?

    American Airlines, at $258, was found to be the cheapest airline from Buffalo to Des Moines. An alternate airline flying to your destination would be Delta. You may be able to fly from Buffalo to Des Moines for 38% less than the average price by searching for these airlines.

  • Can I find deals for flights from Buffalo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Buffalo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Des Moines.

  • Can I find deals for business class flights from Buffalo to Des Moines?

    Yes. Cheapflights offers flight deals from Buffalo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines

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Top 2 airlines flying from Buffalo to Des Moines

Discover the top 2 airlines that operate flights from Buffalo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$427FlexibilityNo cancel feeOn-time71%
DeltaCheapest$319Average$549FlexibilityNo cancel feeOn-timeN/A

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