HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$159+ Cheap flights from Buffalo to Des Moines (BUF - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/6. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — DSM
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Buffalo to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Buffalo to Des Moines

Cheapest flights from Buffalo to Des Moines
Explore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 16, 2025.

This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/251:59 pmBUF - DSM
1 stop5h 06mUnited Airlines
Thu 1/13:14 pmDSM - BUF
1 stop4h 40mUnited Airlines
Deal found 12/16$269
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:15 amBUF - DSM
2 stops6h 10mSouthwest
Thu 1/16:15 amDSM - BUF
2 stops8h 35mSouthwest
Deal found 12/16$509
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:10 amBUF - DSM
1 stop4h 39mDelta
Fri 1/25:21 pmDSM - BUF
1 stop5h 07mDelta
Deal found 12/16$522
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:05 amBUF - DSM
2 stops5h 55mSouthwest
Fri 1/26:50 pmDSM - BUF
2 stops12h 00mSouthwest
Deal found 12/16$549
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:30 amBUF - DSM
1 stop5h 20mUnited Airlines
Fri 1/23:14 pmDSM - BUF
1 stop4h 40mUnited Airlines
Deal found 12/16$557
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:30 amBUF - DSM
1 stop5h 20mUnited Airlines
Sun 12/2111:35 amDSM - BUF
1 stop4h 19mUnited Airlines
Deal found 12/15$677
This Southwest deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/193:10 pmBUF - DSM
2 stops9h 55mSouthwest
Sun 12/215:30 amDSM - BUF
2 stops12h 50mSouthwest
Deal found 12/15$687
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:05 amBUF - DSM
2 stops5h 50mSouthwest
Sat 12/275:40 amDSM - BUF
2 stops10h 50mSouthwest
Deal found 12/16$692
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/205:35 pmBUF - DSM
1 stop5h 05mUnited Airlines
Sat 12/273:14 pmDSM - BUF
1 stop4h 40mUnited Airlines
Deal found 12/16$713

Find flight deals from Buffalo to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$379
(Delta)

One-way from

$159
(United Airlines)

Popular in

January

Cheapest in

June

Average price

$382
Provider with most accurate pricing for Buffalo-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Des Moines flights.
Search Deals
From Buffalo to Des Moines
Search Deals
One-way flight from Buffalo to Des Moines
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($64 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.

Fly from

Buffalo

Fly to

Des Moines

Route

Depart

Return

Price

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 1/8

2:56 pm-7:34 pm

1 stop5h 38m

Des Moines

Sun 1/11

6:24 am-11:27 am

1 stop4h 03m

$379

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sat 2/21

7:00 am-10:53 am

1 stop4h 53m

Des Moines

Wed 2/25

3:24 pm-8:51 pm

1 stop4h 27m

$384

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 1/30

6:00 am-10:41 am

1 stop5h 41m

Des Moines

Fri 2/6

5:49 pm-10:57 pm

1 stop4h 08m

$387

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 5/7

6:00 am-11:45 am

1 stop6h 45m

Des Moines

Sun 5/17

5:20 am-10:25 am

1 stop4h 05m

$417

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 5/7

5:45 am-1:15 pm

2 stops8h 30m

Des Moines

Sun 5/10

5:20 am-2:15 pm

2 stops7h 55m

$447

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 1/6

10:45 am-2:33 pm

1 stop4h 48m

$159

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sun 1/11

1:15 pm-7:22 pm

2 stops31h 07m

$174

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sun 1/11

6:03 am-11:24 am

1 stop6h 21m

$204

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Sun 1/11

1:15 pm-10:19 am

3 stops22h 04m

$207

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 12/26

8:50 am-2:58 pm

1 stop7h 08m

$271

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 11 results
1
2

Compare providers for flights from Buffalo to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Des Moines in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Buffalo-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Buffalo-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Des Moines

What is the cheapest month to book a flight from Buffalo to Des Moines?

Currently, June is the cheapest month in which you can book a flight from Buffalo to Des Moines (average of $119). Flying from Buffalo to Des Moines in January is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 16, 2025.
Read through reviews of airlines operating flights from Buffalo to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Food

7.3

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Food

7.3

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,049 reviews
Delta
7.9
Good
8,008 reviews

Food

7.3

Crew

8.5

Boarding

8.1

Entertainment

7.9

Overall

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Des Moines?

    A quick flight from Buffalo to Des Moines can take about 4h 53m. Delta provides one of the quickest options available for as low as $384. The distance between Buffalo and Des Moines is about 768 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Des Moines round-trip?

    Delta, at $213, was found to be the cheapest airline from Buffalo to Des Moines. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Buffalo to Des Moines for 47% less than the average price by searching for these airlines.

  • Can I find deals for flights from Buffalo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Buffalo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Des Moines.

  • Can I find deals for business class flights from Buffalo to Des Moines?

    Yes. Cheapflights offers flight deals from Buffalo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Des Moines?

    Currently, June is the cheapest month in which you can book a flight from Buffalo to Des Moines (average of $119). Flying from Buffalo to Des Moines in January is currently the most expensive (average of $466). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Buffalo to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
LaGuardia to Omaha flights
John F Kennedy Intl to Omaha flights
Newark to Omaha flights
John F Kennedy Intl to Cedar Rapids flights
Newark to Cedar Rapids flights
John F Kennedy Intl to Des Moines flights
LaGuardia to Des Moines flights
LaGuardia to Cedar Rapids flights
Newark to Des Moines flights
Syracuse to Omaha flights
John F Kennedy Intl to Moline flights
Syracuse to Cedar Rapids flights
Buffalo to Omaha flights
Albany to Des Moines flights
LaGuardia to Moline flights
Albany to Cedar Rapids flights
Rochester to Cedar Rapids flights
Stewart to Cedar Rapids flights
Newark to Moline flights
Albany to Omaha flights
Newark to Sioux City flights
Stewart to Des Moines flights
Syracuse to Des Moines flights
LaGuardia to Sioux City flights
Albany to Moline flights
White Plains to Des Moines flights
White Plains to Omaha flights
Buffalo to Cedar Rapids flights
Stewart to Omaha flights
Newark to La Crosse flights
Rochester to Omaha flights
LaGuardia to La Crosse flights
Rochester to Des Moines flights
John F Kennedy Intl to La Crosse flights
LaGuardia to Dubuque flights
Rochester to Moline flights
Binghamton to Omaha flights
Ithaca to Omaha flights
Newark to Dubuque flights
Ithaca to Des Moines flights
Buffalo to Moline flights
Rochester to Sioux City flights
Ithaca to Cedar Rapids flights
Elmira to Des Moines flights
Ithaca to Moline flights
LaGuardia to Waterloo flights
Buffalo to Waterloo flights
John F Kennedy Intl to Waterloo flights

Top 2 airlines flying from Buffalo to Des Moines

Discover the top 2 airlines that operate flights from Buffalo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$426FlexibilityNo cancel feeOn-time71%
DeltaCheapest$279Average$497FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.