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Des Moines

$157+ Cheap flights from Buffalo to Des Moines (BUF - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — DSM
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Buffalo to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$350
(Delta)

One-way from

$157
(American Airlines)

Popular in

October

Cheapest in

June

Average price

$347
From Buffalo to Des Moines
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One-way flight from Buffalo to Des Moines
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Highest demand for flights based on searches. 22% potential increase in price ($126 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($43 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Buffalo to Des Moines

Cheapest flights from Buffalo to Des Moines
Explore the most affordable flight options available from Buffalo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:20 amBUF - DSM
1 stop4h 00mDelta
Sun 10/196:05 amDSM - BUF
1 stop5h 04mDelta
Deal found 9/15$350
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:33 pmBUF - DSM
1 stop7h 26mAmerican Airlines
Sun 10/266:07 pmDSM - BUF
1 stop4h 28mAmerican Airlines
Deal found 9/16$407
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:30 amBUF - DSM
2 stops8h 53mUnited Airlines
Sun 10/191:00 pmDSM - BUF
1 stop7h 13mUnited Airlines
Deal found 9/15$446
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:00 amBUF - DSM
1 stop5h 30mDelta
Sat 10/45:12 pmDSM - BUF
1 stop5h 25mDelta
Deal found 9/15$447
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/307:07 amBUF - DSM
1 stop4h 25mUnited Airlines
Sat 10/48:00 amDSM - BUF
2 stops9h 13mUnited Airlines
Deal found 9/15$452
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/198:33 amBUF - DSM
1 stop8h 40mUnited Airlines
Sun 9/213:25 pmDSM - BUF
1 stop4h 51mUnited Airlines
Deal found 9/15$647

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Buffalo to Des Moines that are best for you.

Fly from

Buffalo

Fly to

Des Moines

Route

Depart

Return

Price

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 10/16

6:20 am-9:20 am

1 stop4h 00m

Des Moines

Sun 10/19

6:05 am-12:09 pm

1 stop5h 04m

$350

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 10/16

11:54 am-5:42 pm

1 stop6h 48m

Des Moines

Sun 10/19

6:44 am-2:44 pm

1 stop7h 00m

$350

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 10/24

5:33 pm-11:59 pm

1 stop7h 26m

Des Moines

Sun 10/26

6:07 pm-11:35 pm

1 stop4h 28m

$407

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 10/16

6:30 am-2:23 pm

2 stops8h 53m

Des Moines

Sun 10/19

1:00 pm-9:13 pm

1 stop7h 13m

$446

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 9/30

6:00 am-10:30 am

1 stop5h 30m

Des Moines

Sat 10/4

5:12 pm-11:37 pm

1 stop5h 25m

$447

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Tue 9/30

7:07 am-4:17 pm

2 stops10h 10m

Des Moines

Sat 10/4

11:31 am-10:42 pm

2 stops10h 11m

$457

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 9/19

8:33 am-4:13 pm

1 stop8h 40m

Des Moines

Sun 9/21

3:25 pm-9:16 pm

1 stop4h 51m

$647

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Fri 9/19

6:49 pm-11:06 pm

1 stop5h 17m

Des Moines

Sun 9/21

6:09 pm-11:53 pm

1 stop4h 44m

$647

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 1/29

8:10 am-11:12 am

1 stop4h 02m

$157

BuffaloDes Moines

BUF - DSM

BUFDSM

Buffalo

Thu 1/29

2:49 pm-9:50 pm

2 stops8h 01m

$162

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 12 results
1
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Best time to book a flight from Buffalo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Des Moines

What is the cheapest month to book a flight from Buffalo to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Buffalo to Des Moines (average of $336). Flying from Buffalo to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 16, 2025.
Read through reviews of airlines operating flights from Buffalo to Des Moines, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Comfort

7.9

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Des Moines?

    A quick flight from Buffalo to Des Moines can take about 4h. Delta provides one of the quickest options available for as low as $350. The distance between Buffalo and Des Moines is about 768 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Buffalo to Des Moines round-trip?

    American Airlines, at $258, was found to be the cheapest airline from Buffalo to Des Moines. An alternate airline flying to your destination would be Delta. You may be able to fly from Buffalo to Des Moines for 40% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Buffalo to Des Moines one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $157. Users have also found prices from $162 and $162 on United Airlines and Southwest, respectively.

  • Can I find deals for flights from Buffalo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Buffalo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Des Moines.

  • Can I find deals for business class flights from Buffalo to Des Moines?

    Yes. Cheapflights offers flight deals from Buffalo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Buffalo to Des Moines (average of $336). Flying from Buffalo to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Buffalo to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Buffalo to Des Moines

Discover the top 2 airlines that operate flights from Buffalo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$426FlexibilityNo cancel feeOn-time71%
DeltaCheapest$316Average$507FlexibilityNo cancel feeOn-timeN/A

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