$334+ Cheap flights from Santa Ana, CA to Columbia, MO (SNA - COU)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — COU
May 7 — May 141
Round-trip
1 adult, Economy
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Find cheap flights from Santa Ana to Columbia with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Ana to Columbia
Cheapest
Best
Last-minute
One-way
Cheapest flights from Santa Ana to ColumbiaExplore the most affordable flight options available from Santa Ana to Columbia. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 7, 2026.
Explore the most affordable flight options available from Santa Ana to Columbia. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 7, 2026.
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:42 pm
SNA
- COU
1 stop6h 11m
American Airlines
Sat 4/2512:06 pm
COU
- SNA
1 stop8h 23m
American Airlines
Deal found 4/5![American Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:27 pm
SNA
- COU
2 stops8h 26m
American Airlines
Sat 4/2510:16 am
COU
- SNA
2 stops9h 45m
American Airlines
Deal found 4/6![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:00 am
SNA
- COU
1 stop6h 13m
American Airlines
Sat 5/26:00 am
COU
- SNA
1 stop8h 38m
American Airlines
Deal found 4/5![American Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
SNA
- COU
1 stop7h 49m
United Airlines
Wed 5/63:10 pm
COU
- SNA
1 stop9h 25m
United Airlines
Deal found 4/5![United Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:10 am
SNA
- COU
1 stop7h 53m
United Airlines
Sat 4/255:00 am
COU
- SNA
1 stop8h 37m
United Airlines
Deal found 4/6![United Airlines logo]()
$478
Best flights from Santa Ana to ColumbiaDiscover carefully curated flight deals from Santa Ana to Columbia that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 7, 2026.
Discover carefully curated flight deals from Santa Ana to Columbia that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 7, 2026.
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
SNA
- COU
1 stop7h 49m
United Airlines
Wed 5/63:10 pm
COU
- SNA
1 stop9h 25m
United Airlines
Deal found 4/5![United Airlines logo]()
$428
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:17 pm
SNA
- COU
2 stops7h 36m
American Airlines
Sat 5/212:06 pm
COU
- SNA
2 stops7h 55m
American Airlines
Deal found 4/5![American Airlines logo]()
$453
Last-minute flights from Santa Ana to ColumbiaDiscover last-minute flight deals from Santa Ana to Columbia. Data last updated April 7, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Ana to Columbia. Data last updated April 7, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2112:27 pm
SNA
- COU
2 stops8h 26m
American Airlines
Sat 4/2510:16 am
COU
- SNA
2 stops9h 45m
American Airlines
Deal found 4/6![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:10 am
SNA
- COU
1 stop7h 53m
United Airlines
Sat 4/255:00 am
COU
- SNA
1 stop8h 37m
United Airlines
Deal found 4/6![United Airlines logo]()
$478
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/222:42 pm
SNA
- COU
1 stop6h 11m
American Airlines
Sat 4/2512:06 pm
COU
- SNA
1 stop8h 23m
American Airlines
Deal found 4/5![American Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:00 am
SNA
- COU
1 stop6h 13m
American Airlines
Sat 5/26:00 am
COU
- SNA
1 stop8h 38m
American Airlines
Deal found 4/5![American Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
SNA
- COU
1 stop7h 49m
United Airlines
Wed 5/63:10 pm
COU
- SNA
1 stop9h 25m
United Airlines
Deal found 4/5![United Airlines logo]()
$428
One-way flights from Santa Ana to ColumbiaSearch for one-way flight options from Santa Ana to Columbia. Find affordable one-way fares based on user searches. Data last updated April 7, 2026.
Search for one-way flight options from Santa Ana to Columbia. Find affordable one-way fares based on user searches. Data last updated April 7, 2026.
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:21 pm
SNA
- COU
1 stop5h 42m
United Airlines
Deal found 4/3![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/149:51 am
SNA
- COU
2 stops9h 39m
American Airlines
Deal found 4/3![American Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:42 pm
SNA
- COU
1 stop6h 11m
American Airlines
Deal found 4/3![American Airlines logo]()
$371
Find flight deals from Santa Ana to Columbia
Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Columbia (COU). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $388 (American Airlines) |
One-way from | $334 (United Airlines) |
Popular in | May |
Cheapest in | December |
Average price | $557 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Ana to Columbia that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 7, 2026.
Use the filters below to find and compare flights from Santa Ana to Columbia that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santa AnaColumbia
SNA - COU
SNACOU
Santa Ana J. Wayne/Orange Cnty
Sat 5/2
11:00 am-8:49 pm
1 stop7h 49m
Columbia Regional
Wed 5/6
3:10 pm-10:35 pm
1 stop9h 25m
$428
Quickest round-trip
Santa AnaColumbia
SNA - COU
SNACOU
Santa Ana J. Wayne/Orange Cnty
Wed 4/29
1:17 pm-10:53 pm
2 stops7h 36m
Columbia Regional
Sat 5/2
12:06 pm-6:01 pm
2 stops7h 55m
$453
Cheapest one-way
Quickest one-way
Santa AnaColumbia
SNA - COU
SNACOU
Santa Ana J. Wayne/Orange Cnty
Tue 4/14
1:21 pm-9:03 pm
1 stop5h 42m
$334
Santa AnaColumbia
SNA - COU
SNACOU
Santa Ana J. Wayne/Orange Cnty
Tue 4/14
9:51 am-9:30 pm
2 stops9h 39m
$340
Santa AnaColumbia
SNA - COU
SNACOU
Santa Ana J. Wayne/Orange Cnty
Wed 4/15
7:44 pm-10:55 am
2 stops13h 11m
$340
Santa AnaColumbia
SNA - COU
SNACOU
Santa Ana J. Wayne/Orange Cnty
Mon 4/13
11:00 am-7:13 pm
1 stop6h 13m
$371
Sorted by cheapest first
Compare providers for flights from Santa Ana to Columbia
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Columbia in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santa Ana, California-Columbia, Missouri flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana, California-Columbia, Missouri flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana, California-Columbia, Missouri flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Ana, California-Columbia, Missouri flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana, California-Columbia, Missouri flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Ana to Columbia
Have a flexible travel schedule? Discover the best time to fly to Columbia from Santa Ana with our price prediction graph.
SNA-COU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Columbia
Get insights into the airlines that provide service to Columbia. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Columbia. Reviews last updated April 7, 2026.
Peruse reviews from past customers who have flown with American Airlines from Santa Ana to Columbia to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.1
Food
6.4
Boarding
7.5
Entertainment
6.9
Comfort
7.2
Crew
7.9
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Overall
7.1
Food
6.4
Boarding
7.5
Entertainment
6.9
Comfort
7.2
Crew
7.9
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Related info for your journey
Find useful and relevant information for your journey from Santa Ana to Columbia. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Columbia?
Book flights to Columbia if you plan to visit one of these locationsJefferson City
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Santa Ana and Columbia flights
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Top airline flying from Santa Ana to Columbia
Discover the top airline that operate flights from Santa Ana to Columbia. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$392 | Average$427 | FlexibilityNo cancel fee | On-time71% |