$164+ Cheap flights from Panama City, FL (ECP) to Chicago (CHI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — CHI
May 29 — Jun 51
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City NW Florida Beaches to Chicago are usually found in July or February, booked 43 days in advance, depart on a Wednesday or Thursday and return on a Tuesday
Cheap flight deals from Panama City to Chicago
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Last-minute
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Cheapest flights from Panama City to ChicagoExplore the most affordable flight options available from Panama City to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
Explore the most affordable flight options available from Panama City to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:03 pm
ECP
- ORD
Nonstop2h 56m
American Airlines
Wed 6/2411:58 am
ORD
- ECP
Nonstop2h 35m
American Airlines
Deal found 4/28![American Airlines logo]()
$327
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:05 pm
ECP
- MDW
1 stop5h 00m
Southwest
Sat 8/87:45 am
MDW
- ECP
Nonstop2h 10m
Southwest
Deal found 4/27![Southwest logo]()
$337
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:05 pm
ECP
- ORD
Nonstop2h 45m
United Airlines
Wed 7/157:00 am
ORD
- ECP
Nonstop2h 37m
United Airlines
Deal found 4/29![United Airlines logo]()
$342
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:30 am
ECP
- MDW
2 stops7h 35m
Southwest
Sat 8/87:45 am
MDW
- ECP
Nonstop2h 10m
Southwest
Deal found 4/27![Southwest logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/173:03 pm
ECP
- ORD
Nonstop2h 56m
American Airlines
Sun 6/2111:59 am
ORD
- ECP
Nonstop2h 35m
American Airlines
Deal found 4/26![American Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/52:45 pm
ECP
- MDW
Nonstop2h 10m
Southwest
Mon 9/71:40 pm
MDW
- ECP
Nonstop2h 05m
Southwest
Deal found 4/28![Southwest logo]()
$344
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/911:59 am
ECP
- ORD
1 stop6h 43m
Delta
Wed 6/245:30 am
ORD
- ECP
1 stop6h 56m
Delta
Deal found 4/27![Delta logo]()
$347
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
ECP
- MDW
1 stop4h 09m
Delta
Wed 6/246:00 am
MDW
- ECP
1 stop6h 26m
Delta
Deal found 4/28![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:15 am
ECP
- ORD
1 stop5h 35m
Southwest
Wed 6/35:55 am
ORD
- ECP
2 stops13h 00m
Southwest
Deal found 4/27![Southwest logo]()
$352
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:05 pm
ECP
- MDW
1 stop5h 00m
Southwest
Wed 8/510:10 am
MDW
- ECP
2 stops8h 00m
Southwest
Deal found 4/28![Southwest logo]()
$352
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/23:14 pm
ECP
- ORD
Nonstop3h 00m
American Airlines
Thu 6/45:34 pm
ORD
- ECP
1 stop6h 06m
American Airlines
Deal found 4/28![American Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:10 am
ECP
- MDW
Nonstop2h 15m
Southwest
Sat 8/110:20 am
MDW
- ECP
1 stop6h 40m
Southwest
Deal found 4/28![Southwest logo]()
$354
Best flights from Panama City to ChicagoDiscover carefully curated flight deals from Panama City to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
Discover carefully curated flight deals from Panama City to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:25 am
ECP
- ORD
Nonstop2h 44m
United Airlines
Wed 6/37:05 am
ORD
- ECP
Nonstop2h 39m
United Airlines
Deal found 4/27![United Airlines logo]()
$327
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/137:46 am
ECP
- ORD
1 stop6h 28m
Delta
Tue 6/166:40 am
ORD
- ECP
1 stop4h 10m
Delta
Deal found 4/24![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:15 am
ECP
- ORD
1 stop5h 35m
Southwest
Wed 6/310:30 am
ORD
- ECP
1 stop7h 15m
Southwest
Deal found 4/27![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
ECP
- MDW
1 stop4h 00m
Delta
Wed 5/2710:59 am
MDW
- ECP
1 stop5h 38m
Delta
Deal found 4/26![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:55 pm
ECP
- MDW
1 stop6h 05m
Southwest
Wed 7/152:35 pm
MDW
- ECP
1 stop6h 35m
Southwest
Deal found 4/29![Southwest logo]()
$347
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/99:19 am
ECP
- MDW
1 stop6h 57m
Delta
Wed 6/246:00 am
MDW
- ECP
1 stop6h 26m
Delta
Deal found 4/26![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:05 pm
ECP
- MDW
1 stop5h 00m
Southwest
Wed 8/510:10 am
MDW
- ECP
2 stops8h 00m
Southwest
Deal found 4/28![Southwest logo]()
$352
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1010:25 am
ECP
- ORD
Nonstop2h 44m
United Airlines
Sun 7/127:00 am
ORD
- ECP
Nonstop2h 37m
United Airlines
Deal found 4/24![United Airlines logo]()
$411
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:15 am
ECP
- MDW
2 stops9h 00m
Southwest
Tue 6/1611:25 am
MDW
- ECP
2 stops8h 15m
Southwest
Deal found 4/29![Southwest logo]()
$357
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1211:38 am
ECP
- ORD
1 stop7h 07m
Delta
Wed 7/158:03 am
ORD
- ECP
1 stop5h 51m
Delta
Deal found 4/28![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:14 pm
ECP
- ORD
Nonstop2h 34m
United Airlines
Sun 5/1710:47 am
ORD
- ECP
Nonstop2h 31m
United Airlines
Deal found 4/24![United Airlines logo]()
$429
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:00 pm
ECP
- MDW
Nonstop2h 25m
Southwest
Mon 6/19:25 am
MDW
- ECP
Nonstop2h 10m
Southwest
Deal found 4/25![Southwest logo]()
$361
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:36 pm
ECP
- ORD
1 stop6h 57m
Delta
Sun 8/99:45 am
ORD
- ECP
1 stop4h 09m
Delta
Deal found 4/28![Delta logo]()
$364
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:00 am
ECP
- MDW
1 stop4h 03m
Delta
Sun 8/96:05 am
MDW
- ECP
1 stop6h 26m
Delta
Deal found 4/28![Delta logo]()
$364
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:25 pm
ECP
- MDW
1 stop3h 50m
Southwest
Thu 6/41:00 pm
MDW
- ECP
1 stop4h 40m
Southwest
Deal found 4/26![Southwest logo]()
$364
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/311:45 pm
ECP
- MDW
2 stops9h 35m
Southwest
Tue 9/11:00 pm
MDW
- ECP
2 stops5h 10m
Southwest
Deal found 4/25![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1011:38 am
ECP
- ORD
1 stop7h 07m
Delta
Sun 7/125:15 am
ORD
- ECP
1 stop5h 33m
Delta
Deal found 4/24![Delta logo]()
$381
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:00 am
ECP
- ORD
1 stop4h 04m
Delta
Mon 8/171:15 pm
ORD
- ECP
1 stop4h 36m
Delta
Deal found 4/26![Delta logo]()
$381
Last-minute flights from Panama City to ChicagoDiscover last-minute flight deals from Panama City to Chicago. Data last updated April 29, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Chicago. Data last updated April 29, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:29 pm
ECP
- ORD
1 stop4h 58m
Delta
Tue 5/197:07 am
ORD
- ECP
1 stop5h 43m
Delta
Deal found 4/26![Delta logo]()
$378
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/202:14 pm
ECP
- ORD
Nonstop2h 34m
United Airlines
Wed 5/277:05 am
ORD
- ECP
Nonstop2h 39m
United Airlines
Deal found 4/26![United Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:06 pm
ECP
- ORD
Nonstop2h 49m
American Airlines
Wed 5/271:19 pm
ORD
- ECP
1 stop5h 07m
American Airlines
Deal found 4/26![American Airlines logo]()
$337
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:00 am
ECP
- MDW
1 stop4h 00m
Delta
Wed 5/2710:59 am
MDW
- ECP
1 stop5h 38m
Delta
Deal found 4/26![Delta logo]()
$347
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/242:05 pm
ECP
- ORD
Nonstop2h 45m
United Airlines
Tue 5/2610:42 am
ORD
- ECP
Nonstop2h 39m
United Airlines
Deal found 4/28![United Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:15 am
ECP
- ORD
1 stop5h 35m
Southwest
Wed 6/35:55 am
ORD
- ECP
2 stops13h 00m
Southwest
Deal found 4/27![Southwest logo]()
$352
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:29 pm
ECP
- ORD
1 stop6h 30m
Delta
Mon 6/18:10 am
ORD
- ECP
1 stop5h 54m
Delta
Deal found 4/24![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:25 am
ECP
- ORD
Nonstop2h 44m
United Airlines
Sun 5/317:05 am
ORD
- ECP
Nonstop2h 39m
United Airlines
Deal found 4/28![United Airlines logo]()
$361
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:14 pm
ECP
- ORD
Nonstop3h 00m
American Airlines
Sun 5/317:02 am
ORD
- ECP
1 stop7h 30m
American Airlines
Deal found 4/28![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:00 pm
ECP
- MDW
Nonstop2h 25m
Southwest
Mon 6/19:25 am
MDW
- ECP
Nonstop2h 10m
Southwest
Deal found 4/25![Southwest logo]()
$361
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3010:45 am
ECP
- ORD
Nonstop2h 35m
Southwest
Mon 6/14:15 pm
ORD
- ECP
1 stop5h 25m
Southwest
Deal found 4/29![Southwest logo]()
$354
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:45 pm
ECP
- ORD
Nonstop2h 50m
American Airlines
Mon 6/112:09 pm
ORD
- ECP
Nonstop2h 35m
American Airlines
Deal found 4/29![American Airlines logo]()
$375
One-way flights from Panama City to ChicagoSearch for one-way flight options from Panama City to Chicago. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
Search for one-way flight options from Panama City to Chicago. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/93:03 pm
ECP
- ORD
Nonstop2h 56m
American Airlines
Deal found 4/28![American Airlines logo]()
$164
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
ECP
- MDW
1 stop6h 00m
Delta
Deal found 4/28![Delta logo]()
$174
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/212:05 pm
ECP
- ORD
2 stops9h 50m
Southwest
Deal found 4/28![Southwest logo]()
$179
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:15 am
ECP
- MDW
2 stops7h 40m
Southwest
Deal found 4/28![Southwest logo]()
$179
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/33:38 pm
ECP
- ORD
Nonstop3h 02m
American Airlines
Deal found 4/28![American Airlines logo]()
$181
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:10 am
ECP
- MDW
Nonstop2h 15m
Southwest
Deal found 4/24![Southwest logo]()
$181
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:45 pm
ECP
- ORD
1 stop5h 14m
Delta
Deal found 4/28![Delta logo]()
$191
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/233:00 pm
ECP
- MDW
1 stop6h 09m
Delta
Deal found 4/29![Delta logo]()
$191
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/68:30 am
ECP
- MDW
2 stops8h 15m
Southwest
Deal found 4/25![Southwest logo]()
$193
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/910:30 am
ECP
- ORD
Nonstop2h 43m
United Airlines
Deal found 4/27![United Airlines logo]()
$195
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:05 pm
ECP
- MDW
Nonstop2h 20m
Southwest
Deal found 4/27![Southwest logo]()
$195
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:50 am
ECP
- MDW
2 stops9h 15m
Southwest
Deal found 4/25![Southwest logo]()
$196
Find flight deals from Panama City to Chicago
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $327 (American Airlines) |
One-way from | $164 (American Airlines) |
Popular in | November |
Cheapest in | July |
Average price | $443 |
Good round-trip deal | $405 or less |
Good one-way deal | $215 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Panama City to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityChicago
ECP - ORD
ECPORD
Panama City NW Florida Beaches
Wed 5/27
10:25 am-1:09 pm
Nonstop2h 44m
Chicago O'Hare Intl
Wed 6/3
7:05 am-9:44 am
Nonstop2h 39m
$327
Panama CityChicago
ECP - ORD
ECPORD
Panama City NW Florida Beaches
Sat 6/13
7:46 am-2:14 pm
1 stop6h 28m
Chicago O'Hare Intl
Tue 6/16
6:40 am-10:50 am
1 stop4h 10m
$347
Panama CityChicago
ECP - ORD
ECPORD
Panama City NW Florida Beaches
Wed 5/27
7:15 am-12:50 pm
1 stop5h 35m
Chicago O'Hare Intl
Wed 6/3
10:30 am-5:45 pm
1 stop7h 15m
$347
Panama CityChicago
ECP - MDW
ECPMDW
Panama City NW Florida Beaches
Wed 5/20
6:00 am-10:00 am
1 stop4h 00m
Chicago Midway
Wed 5/27
10:59 am-4:37 pm
1 stop5h 38m
$347
Panama CityChicago
ECP - MDW
ECPMDW
Panama City NW Florida Beaches
Wed 7/1
3:55 pm-10:00 pm
1 stop6h 05m
Chicago Midway
Wed 7/15
2:35 pm-9:10 pm
1 stop6h 35m
$347
Panama CityChicago
ECP - MDW
ECPMDW
Panama City NW Florida Beaches
Tue 6/9
9:19 am-4:16 pm
1 stop6h 57m
Chicago Midway
Wed 6/24
6:00 am-12:26 pm
1 stop6h 26m
$347
Panama CityChicago
ECP - MDW
ECPMDW
Panama City NW Florida Beaches
Sat 8/1
6:05 pm-11:05 pm
1 stop5h 00m
Chicago Midway
Wed 8/5
10:10 am-6:10 pm
2 stops8h 00m
$352
Panama CityChicago
ECP - MDW
ECPMDW
Panama City NW Florida Beaches
Tue 6/2
7:15 am-4:15 pm
2 stops9h 00m
Chicago Midway
Tue 6/16
11:25 am-7:40 pm
2 stops8h 15m
$357
Quickest round-trip
Panama CityChicago
ECP - MDW
ECPMDW
Panama City NW Florida Beaches
Fri 5/29
5:00 pm-7:25 pm
Nonstop2h 25m
Chicago Midway
Mon 6/1
9:25 am-11:35 am
Nonstop2h 10m
$361
Panama CityChicago
ECP - ORD
ECPORD
Panama City NW Florida Beaches
Sun 7/12
11:38 am-6:45 pm
1 stop7h 07m
Chicago O'Hare Intl
Wed 7/15
8:03 am-1:54 pm
1 stop5h 51m
$364
Showing 1-10 of 39 resultsSorted by cheapest first
Compare providers for flights from Panama City to Chicago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Chicago in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Chicago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Chicago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Chicago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Chicago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama City with our price prediction graph.
ECP-CHI
ECP-ORD
ECP-MDW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Chicago
ECP-CHI
ECP-ORD
ECP-MDW
What is the cheapest month to book a flight from Panama City, Florida to Chicago?
Currently, June is the cheapest month in which you can book a flight from Panama City, Florida to Chicago (average of $87). Flying from Panama City, Florida to Chicago in November is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to CHI?
Find hourly flight availability from Panama City to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2026.
Unlike in the evening, when flights are generally more expensive, you can save up to 46% on flights from Panama City, Florida to Chicago by exploring options for tickets at noon.
Weekly flight availability from Panama City, Florida to Chicago
Explore weekly flight availability from Panama City to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated April 29, 2026.
The most flights from ECP to CHI are scheduled on a Wednesday (3 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (1 on average).
How much does it cost to fly round-trip from Panama City, Florida to Chicago?
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated April 29, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Panama City to Chicago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Crew
8.6
Boarding
8.1
Overall
8.0
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Panama City to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
Hammond
Porter
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Other flights to Chicago
Explore flights to Chicago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Complete your trip
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Panama City and Chicago flights
Browse other Panama City and Chicago flight options. Last updated on April 29, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Panama City to Chicago
Discover the top 4 airlines that operate flights from Panama City to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$196 | Average$258 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$207 | Average$368 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$227 | Average$377 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$401 | FlexibilityNo cancel fee | On-time63% |