$112+ Cheap flights from Panama City, FL (ECP) to Chicago (CHI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — CHI
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Chicago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Chicago
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Cheapest flights from Panama City to ChicagoExplore the most affordable flight options available from Panama City to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Panama City to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:34 pm -
1 stop6h 23m
Wed 10/2810:44 am -
1 stop5h 53m
Deal found 9/15![Delta logo]()
$223
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:34 pm -
1 stop4h 59m
Tue 10/2710:59 am -
1 stop5h 38m
Deal found 9/15![Delta logo]()
$223
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:20 pm -
1 stop5h 37m
Tue 10/271:23 pm -
1 stop6h 40m
Deal found 9/15![Delta logo]()
$237
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:20 pm -
1 stop4h 13m
Tue 10/2710:59 am -
1 stop5h 38m
Deal found 9/15![Delta logo]()
$237
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2211:21 am -
1 stop5h 37m
Mon 10/263:40 pm -
1 stop5h 26m
Deal found 9/15![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:30 pm -
1 stop6h 03m
Mon 10/266:04 am -
1 stop6h 46m
Deal found 9/15![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop4h 11m
Tue 10/2710:44 am -
1 stop5h 53m
Deal found 9/15![Delta logo]()
$252
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:20 pm -
1 stop4h 13m
Tue 10/2712:49 pm -
1 stop3h 48m
Deal found 9/15![Delta logo]()
$252
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/33:50 pm -
2 stops6h 55m
Mon 12/77:05 am -
1 stop8h 05m
Deal found 9/15![Southwest logo]()
$256
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop4h 11m
Mon 10/266:30 am -
1 stop6h 20m
Deal found 9/15![Delta logo]()
$266
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:30 pm -
1 stop6h 03m
Mon 10/266:04 am -
1 stop4h 31m
Deal found 9/15![Delta logo]()
$266
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:20 pm -
1 stop6h 40m
Wed 10/289:40 am -
1 stop5h 00m
Deal found 9/13![Southwest logo]()
$270
Best flights from Panama City to ChicagoDiscover carefully curated flight deals from Panama City to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Panama City to Chicago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:05 am -
1 stop4h 54m
Sun 11/156:00 am -
1 stop6h 42m
Deal found 9/15![Delta logo]()
$295
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/212:08 pm -
Nonstop2h 52m
Mon 1/2510:35 am -
Nonstop2h 42m
Deal found 9/12![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:55 pm -
2 stops7h 15m
Sun 11/155:20 am -
1 stop5h 25m
Deal found 9/15![Southwest logo]()
$320
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:10 pm -
1 stop6h 30m
Sun 12/137:20 am -
2 stops9h 20m
Deal found 9/16![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:19 pm -
1 stop4h 25m
Sun 10/46:05 am -
1 stop6h 34m
Deal found 9/14![Delta logo]()
$379
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:25 am -
2 stops8h 55m
Mon 10/55:15 am -
1 stop5h 00m
Deal found 9/16![Southwest logo]()
$370
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:57 pm -
1 stop7h 26m
Mon 10/1210:30 am -
Nonstop2h 33m
Deal found 9/16![United Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:19 pm -
1 stop4h 25m
Sun 10/46:05 am -
1 stop6h 34m
Deal found 9/14![Delta logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/244:55 pm -
1 stop6h 31m
Wed 12/210:50 am -
Nonstop2h 27m
Deal found 9/15![United Airlines logo]()
$420
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:30 am -
2 stops8h 00m
Tue 12/2910:05 am -
2 stops9h 15m
Deal found 9/14![Southwest logo]()
$385
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:59 pm -
1 stop3h 56m
Sun 12/206:00 am -
1 stop4h 15m
Deal found 9/15![Delta logo]()
$385
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop5h 54m
Sun 10/116:04 am -
1 stop4h 27m
Deal found 9/15![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:50 pm -
1 stop6h 52m
Mon 10/510:30 am -
Nonstop2h 33m
Deal found 9/16![United Airlines logo]()
$451
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:40 pm -
1 stop7h 30m
Sun 11/112:45 pm -
2 stops7h 45m
Deal found 9/14![Southwest logo]()
$434
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:57 pm -
1 stop7h 26m
Sun 10/410:30 am -
Nonstop2h 33m
Deal found 9/16![United Airlines logo]()
$465
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:45 pm -
1 stop5h 53m
Thu 10/296:30 am -
1 stop4h 05m
Deal found 9/13![Delta logo]()
$444
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:08 pm -
Nonstop2h 42m
Sun 10/410:30 am -
Nonstop2h 33m
Deal found 9/15![United Airlines logo]()
$474
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:34 pm -
1 stop4h 59m
Thu 10/296:04 am -
1 stop4h 31m
Deal found 9/12![Delta logo]()
$444
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/22:08 pm -
Nonstop2h 52m
Wed 2/310:35 am -
Nonstop2h 42m
Deal found 9/16![United Airlines logo]()
$477
Last-minute flights from Panama City to ChicagoDiscover last-minute flight deals from Panama City to Chicago. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Chicago. Data last updated September 17, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:34 pm -
1 stop6h 23m
Sat 10/245:27 am -
1 stop5h 08m
Deal found 9/15![Delta logo]()
$223
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:34 pm -
1 stop4h 59m
Wed 10/285:09 pm -
1 stop6h 09m
Deal found 9/15![Delta logo]()
$223
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:34 pm -
1 stop6h 23m
Sun 10/255:27 am -
1 stop5h 08m
Deal found 9/15![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:20 pm -
1 stop6h 40m
Wed 10/289:40 am -
1 stop5h 00m
Deal found 9/13![Southwest logo]()
$270
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:20 pm -
1 stop5h 37m
Tue 10/271:23 pm -
1 stop6h 40m
Deal found 9/15![Delta logo]()
$237
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:20 pm -
1 stop4h 13m
Tue 10/2710:59 am -
1 stop5h 38m
Deal found 9/15![Delta logo]()
$237
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2211:21 am -
1 stop5h 37m
Mon 10/263:40 pm -
1 stop5h 26m
Deal found 9/15![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:30 pm -
1 stop6h 03m
Mon 10/266:04 am -
1 stop6h 46m
Deal found 9/15![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop4h 11m
Wed 10/286:08 pm -
1 stop5h 10m
Deal found 9/15![Delta logo]()
$252
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:20 pm -
1 stop4h 13m
Tue 10/2712:49 pm -
1 stop3h 48m
Deal found 9/15![Delta logo]()
$252
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop4h 11m
Mon 10/266:30 am -
1 stop6h 20m
Deal found 9/15![Delta logo]()
$266
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:30 pm -
1 stop6h 03m
Mon 10/266:04 am -
1 stop4h 31m
Deal found 9/15![Delta logo]()
$266
One-way flights from Panama City to ChicagoSearch for one-way flight options from Panama City to Chicago. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Panama City to Chicago. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:05 am -
1 stop5h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$112
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1211:21 am -
1 stop3h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Delta logo]()
$112
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:10 pm -
2 stops7h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Southwest logo]()
$117
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
1 stop6h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$126
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:10 pm -
1 stop7h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$126
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/143:50 pm -
2 stops6h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$131
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:20 pm -
1 stop6h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Southwest logo]()
$135
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:34 pm -
1 stop5h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Delta logo]()
$141
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:11 pm -
1 stop6h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Delta logo]()
$141
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:20 pm -
1 stop4h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Delta logo]()
$146
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/166:40 am -
Nonstop2h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$160
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:15 am -
1 stop7h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![American Airlines logo]()
$166
Find flight deals from Panama City to Chicago
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $223 (Delta) |
One-way from | $112 (Delta) |
Popular in | November |
Cheapest in | February |
Average price | $367 |
Good round-trip deal | $380 or less |
Good one-way deal | $209 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Panama City to Chicago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityChicago
ECP Panama City NW Florida Beaches - MDW Chicago Midway
ECPMDW
Panama City NW Florida Beaches
Wed 12/16
6:00 am-12:05 pm
1 stop6h 05m
Chicago Midway
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$112
Panama CityChicago
ECP Panama City NW Florida Beaches - MDW Chicago Midway
ECPMDW
Panama City NW Florida Beaches
Thu 11/12
6:55 pm-10:54 pm
1 stop3h 59m
Chicago Midway
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$126
Panama CityChicago
ECP Panama City NW Florida Beaches - MDW Chicago Midway
ECPMDW
Panama City NW Florida Beaches
Thu 12/17
6:00 am-12:05 pm
1 stop6h 05m
Chicago Midway
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$126
Panama CityChicago
ECP Panama City NW Florida Beaches - ORD Chicago O'Hare Intl
ECPORD
Panama City NW Florida Beaches
Fri 12/11
4:06 pm-8:49 pm
1 stop4h 43m
Chicago O'Hare Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$141
Panama CityChicago
ECP Panama City NW Florida Beaches - MDW Chicago Midway
ECPMDW
Panama City NW Florida Beaches
Tue 10/13
6:20 pm-10:33 pm
1 stop4h 13m
Chicago Midway
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
Quickest round-trip
Panama CityChicago
ECP Panama City NW Florida Beaches - MDW Chicago Midway
ECPMDW
Panama City NW Florida Beaches
Tue 3/16
6:40 am-9:00 am
Nonstop2h 20m
Chicago Midway
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$160
Panama CityChicago
ECP Panama City NW Florida Beaches - ORD Chicago O'Hare Intl
ECPORD
Panama City NW Florida Beaches
Sun 11/15
6:00 am-10:25 am
1 stop4h 25m
Chicago O'Hare Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
Panama CityChicago
ECP Panama City NW Florida Beaches - MDW Chicago Midway
ECPMDW
Panama City NW Florida Beaches
Mon 12/14
11:21 am-4:17 pm
1 stop4h 56m
Chicago Midway
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
Panama CityChicago
ECP Panama City NW Florida Beaches - MDW Chicago Midway
ECPMDW
Panama City NW Florida Beaches
Sat 10/17
5:10 pm-10:20 pm
1 stop5h 10m
Chicago Midway
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$190
Panama CityChicago
ECP Panama City NW Florida Beaches - MDW Chicago Midway
ECPMDW
Panama City NW Florida Beaches
Sat 10/10
5:55 am-2:00 pm
1 stop8h 05m
Chicago Midway
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$195
Showing 1-10 of 41 resultsSorted by cheapest first
Compare providers for flights from Panama City to Chicago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Chicago in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Chicago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Chicago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Chicago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Chicago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Chicago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Chicago
Have a flexible travel schedule? Discover the best time to fly to Chicago from Panama City with our price prediction graph.
ECP-CHI
ECP-MDW
ECP-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Chicago
ECP-CHI
ECP-MDW
ECP-ORD
What is the cheapest month to book a flight from Panama City, Florida to Chicago?
Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Chicago (average of $269). Flying from Panama City, Florida to Chicago in July is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from ECP to CHI?
Find hourly flight availability from Panama City to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2026.
Unlike in the evening, when flights are generally more expensive, you can save up to 42% on flights from Panama City, Florida to Chicago by exploring options for tickets at noon.
Weekly flight availability from Panama City, Florida to Chicago
Explore weekly flight availability from Panama City to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 17, 2026.
The most flights from ECP to CHI are scheduled on a Monday (2 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (1 on average).
How much does it cost to fly round-trip from Panama City, Florida to Chicago?
Airfare is below average for this route at the moment.
Panama City, Florida to Chicago flights typically cost between $343 and $396 in October.The cheapest round-trip price found within the last 5 days was $223 on Delta (Oct 20-Oct 27).
How far ahead should I book a flight from Panama City, Florida to Chicago?
The price you pay for your flight from Panama City, Florida to Chicago may vary depending on when you book. For the best chance of a lower fare, look to book 53 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing Chicago
Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated September 17, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Panama City to Chicago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Related info for your journey
Find useful and relevant information for your journey from Panama City to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago?
Book flights to Chicago if you plan to visit one of these locationsBenton Harbor
Lansing
Merrillville
Valparaiso
Hammond
Saint Joseph
Porter
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Other flights to Chicago
Explore flights to Chicago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
Complete your trip
Complete your trip to Chicago by adding a car rental and/or hotel reservation to your travel itinerary.
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Panama City and Chicago flights
Browse other Panama City and Chicago flight options. Last updated on September 17, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Panama City to Chicago
Discover the top 4 airlines that operate flights from Panama City to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$209 | Average$407 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$226 | Average$313 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$402 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$237 | Average$414 | FlexibilityNo cancel fee | On-time63% |