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Central America

$132+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
Nov 21 — Nov 281
Fri 11/21
Fri 11/28
1 adult, Economy
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Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

This Mytrip deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/179:09 pmTYS - GUA
2 stops17h 41mMultiple Airlines
Mon 11/242:55 pmGUA - TYS
1 stop6h 57mMultiple Airlines
Deal found 10/20$289
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/59:23 amTYS - SJO
1 stop28h 02mMultiple Airlines
Thu 12/111:31 pmSJO - TYS
1 stop18h 02mMultiple Airlines
Deal found 10/19$302
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:43 pmTYS - GUA
2 stops26h 22mMultiple Airlines
Thu 12/111:29 pmGUA - TYS
1 stop18h 04mMultiple Airlines
Deal found 10/20$329
This Mytrip deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/38:30 amTYS - SJO
1 stop7h 50mMultiple Airlines
Wed 11/512:34 pmSJO - TYS
2 stops19h 30mMultiple Airlines
Deal found 10/22$360
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/59:23 amTYS - SJO
1 stop28h 02mMultiple Airlines
Fri 12/121:31 pmSJO - TYS
1 stop21h 32mMultiple Airlines
Deal found 10/21$371
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1510:54 amTYS - GUA
2 stops25h 27mMultiple Airlines
Thu 11/202:55 pmGUA - TYS
1 stop29h 35mMultiple Airlines
Deal found 10/21$371
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:08 amTYS - GUA
1 stop26h 16mMultiple Airlines
Tue 1/131:59 amGUA - TYS
1 stop12h 58mMultiple Airlines
Deal found 10/21$379
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1412:31 pmTYS - SJO
1 stop24h 11mMultiple Airlines
Thu 12/181:31 pmSJO - TYS
1 stop6h 42mMultiple Airlines
Deal found 10/19$389
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:12 pmTYS - SJO
1 stop20h 13mMultiple Airlines
Thu 12/181:31 pmSJO - TYS
1 stop6h 42mMultiple Airlines
Deal found 10/20$401
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/77:11 pmTYS - SJO
1 stop18h 14mMultiple Airlines
Sun 12/141:31 pmSJO - TYS
1 stop18h 02mMultiple Airlines
Deal found 10/21$404
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:56 pmTYS - SJO
2 stops22h 34mMultiple Airlines
Thu 12/181:31 pmSJO - TYS
1 stop6h 42mMultiple Airlines
Deal found 10/19$405
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amTYS - PTY
1 stop9h 42mAmerican Airlines
Thu 12/114:43 pmPTY - TYS
2 stops17h 11mAmerican Airlines
Deal found 10/20$460

Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated October 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$289
(Mytrip)

One-way from

$132
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$663
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
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From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($163 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($60 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Mon 11/17

9:09 pm-12:26 pm

1 stop16h 17m

Guatemala City La Aurora

Mon 11/24

2:55 pm-10:52 pm

1 stop6h 57m

$291

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Thu 12/4

12:43 pm-2:05 pm

2 stops26h 22m

Guatemala City La Aurora

Thu 12/11

1:29 pm-8:33 am

1 stop18h 04m

$329

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sat 11/15

10:54 am-11:21 am

2 stops25h 27m

Guatemala City La Aurora

Thu 11/20

2:55 pm-9:30 pm

1 stop29h 35m

$371

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sun 12/14

12:31 pm-11:42 am

1 stop24h 11m

San José Juan Santamaria Intl

Thu 12/18

1:31 pm-9:13 pm

1 stop6h 42m

$389

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Thu 12/11

5:12 pm-3:20 pm

2 stops23h 08m

San José Juan Santamaria Intl

Thu 12/18

1:31 pm-9:13 pm

1 stop6h 42m

$401

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sun 12/7

7:11 pm-12:25 pm

1 stop18h 14m

San José Juan Santamaria Intl

Sun 12/14

1:31 pm-8:33 am

1 stop18h 02m

$404

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Fri 12/12

5:56 pm-3:30 pm

2 stops22h 34m

San José Juan Santamaria Intl

Thu 12/18

1:31 pm-9:13 pm

1 stop6h 42m

$405

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sun 12/14

5:23 pm-11:42 am

2 stops19h 19m

San José Juan Santamaria Intl

Mon 12/22

12:39 pm-9:53 pm

1 stop8h 14m

$421

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Fri 12/12

5:56 pm-3:30 pm

2 stops22h 34m

San José Juan Santamaria Intl

Mon 12/22

12:39 pm-9:53 pm

1 stop8h 14m

$423

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Thu 12/11

5:12 pm-12:25 pm

1 stop20h 13m

San José Juan Santamaria Intl

Sun 12/14

1:31 pm-8:33 am

1 stop18h 02m

$425

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/21

Showing 1-10 of 41 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 22, 2025.

One of the essential ways to save on airfare from Knoxville to Central America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 26% on airfare.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated October 22, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,981 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,981 reviews
Delta
7.9
Good
7,981 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,990 reviews
Delta
7.9
Good
7,981 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,028 reviews
Delta
7.9
Good
7,981 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Central America?

    Departing from Knoxville to Central America will take you 7h 23m. There are 1640 mi between Knoxville and Central America. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - Panama City Tocumen Intl or Knoxville McGhee Tyson - Managua Augusto C Sandino, Knoxville McGhee Tyson - San José Juan Santamaria Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Central America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$594FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$382Average$656FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$800FlexibilityNo cancel feeOn-time69%

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