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Central America

$132+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
ago. 23 — ago. 301
sáb. 8/23
sáb. 8/30
1 adult, Economy
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Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated agosto 18, 2025.

Round-trip from

$337
(Kiwi.com)

One-way from

$132
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$577
From Knoxville McGhee Tyson to Central America
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One-way flight from Knoxville McGhee Tyson to Central America
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Highest demand for flights based on searches. 19% potential increase in price ($151 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($55 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/1411:23 amTYS - GUA
1 stop25h 59mMultiple Airlines
sáb. 10/1812:27 pmGUA - TYS
1 stop29h 44mMultiple Airlines
Deal found 8/17$337
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/2912:45 pmTYS - GUA
2 stops36h 44mMultiple Airlines
sáb. 9/612:20 pmGUA - TYS
1 stop20h 58mMultiple Airlines
Deal found 8/18$346
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/108:44 pmTYS - SJO
1 stop16h 46mMultiple Airlines
lun. 10/1312:35 pmSJO - TYS
1 stop19h 58mMultiple Airlines
Deal found 8/16$349
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/412:08 pmTYS - GUA
1 stop25h 17mMultiple Airlines
jue. 9/1812:20 pmGUA - TYS
2 stops27h 14mMultiple Airlines
Deal found 8/17$375
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/249:12 pmTYS - MGA
1 stop21h 28mMultiple Airlines
dom. 8/3110:00 amMGA - TYS
1 stop8h 22mMultiple Airlines
Deal found 8/17$443
This Kiwi.com deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/65:31 pmTYS - SJO
1 stop19h 59mMultiple Airlines
vie. 10/1012:35 pmSJO - TYS
1 stop19h 43mMultiple Airlines
Deal found 8/16$446
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/125:56 pmTYS - SJO
2 stops20h 36mMultiple Airlines
sáb. 12/205:10 pmSJO - TYS
1 stop27h 46mMultiple Airlines
Deal found 8/18$464
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/95:45 amTYS - SJO
1 stop8h 25mDelta
mié. 10/221:23 pmSJO - TYS
1 stop7h 44mDelta
Deal found 8/18$474
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/37:48 amTYS - SJO
2 stops12h 47mAmerican Airlines
jue. 12/1111:35 amSJO - TYS
1 stop10h 45mAmerican Airlines
Deal found 8/17$478
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/116:00 amTYS - BZE
1 stop7h 08mAmerican Airlines
sáb. 11/222:40 pmBZE - TYS
1 stop8h 05mAmerican Airlines
Deal found 8/18$484
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/17:05 amTYS - SJO
1 stop7h 03mDelta
lun. 10/61:23 pmSJO - TYS
1 stop8h 23mDelta
Deal found 8/17$492
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/17:18 amTYS - SJO
2 stops14h 24mAmerican Airlines
lun. 10/62:40 pmSJO - TYS
1 stop6h 59mAmerican Airlines
Deal found 8/17$496

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 18, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

mar. 10/14

11:23 am-11:22 am

1 stop25h 59m

Guatemala City La Aurora

sáb. 10/18

12:27 pm-8:11 pm

1 stop29h 44m

$337

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

vie. 8/29

12:45 pm-11:29 pm

2 stops36h 44m

Guatemala City La Aurora

sáb. 9/6

12:20 pm-11:18 am

1 stop20h 58m

$346

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

vie. 10/10

8:44 pm-11:30 am

1 stop16h 46m

San José Juan Santamaria Intl

lun. 10/13

12:35 pm-10:33 am

1 stop19h 58m

$349

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

jue. 9/4

12:08 pm-11:25 am

1 stop25h 17m

Guatemala City La Aurora

jue. 9/18

12:20 pm-5:34 pm

2 stops27h 14m

$375

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

lun. 10/6

5:31 pm-11:30 am

1 stop19h 59m

San José Juan Santamaria Intl

vie. 10/10

12:35 pm-10:18 am

1 stop19h 43m

$446

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

mar. 9/9

5:45 am-12:10 pm

1 stop8h 25m

San José Juan Santamaria Intl

mié. 10/22

1:23 pm-11:07 pm

1 stop7h 44m

$474

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

mar. 9/9

10:57 am-7:42 pm

2 stops10h 45m

San José Juan Santamaria Intl

mié. 10/22

1:00 pm-9:32 am

2 stops18h 32m

$478

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

mar. 11/11

6:00 am-12:08 pm

1 stop7h 08m

Belize City Philip S.W.Goldson

sáb. 11/22

2:40 pm-11:45 pm

1 stop8h 05m

$484

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

mié. 10/1

5:45 am-12:08 pm

1 stop8h 23m

San José Juan Santamaria Intl

lun. 10/6

1:23 pm-11:46 pm

1 stop8h 23m

$492

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

mié. 10/1

7:18 am-7:42 pm

2 stops14h 24m

San José Juan Santamaria Intl

lun. 10/6

2:40 pm-11:39 pm

1 stop6h 59m

$496

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Showing 1-10 of 52 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 18, 2025.

When flying from Knoxville to Central America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated agosto 18, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,925 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Overall

8.0

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Central America?

    Departing from Knoxville to Central America will take you 7h 08m. There are 1289 mi between Knoxville and Central America. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - Panama City Tocumen Intl or Knoxville McGhee Tyson - Liberia, Knoxville McGhee Tyson - San José Juan Santamaria Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$602FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$382Average$649FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$798FlexibilityNo cancel feeOn-time69%

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