HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Central America

$201+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
ene. 9 — ene. 161
vie. 1/9
vie. 1/16
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Central America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 10, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/121:05 pmTYS - SJO
1 stop23h 37mMultiple Airlines
vie. 12/191:31 pmSJO - TYS
1 stop30h 02mMultiple Airlines
Deal found 12/7$503
This Kiwi.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/121:05 pmTYS - SJO
1 stop23h 37mMultiple Airlines
dom. 12/141:31 pmSJO - TYS
1 stop18h 02mMultiple Airlines
Deal found 12/8$521
This American Airlines deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/127:38 amTYS - SJO
2 stops14h 11mAmerican Airlines
vie. 12/1911:32 amSJO - TYS
1 stop12h 06mAmerican Airlines
Deal found 12/7$546
This Kiwi.com deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/239:27 pmTYS - GUA
2 stops17h 36mMultiple Airlines
jue. 1/112:20 pmGUA - TYS
1 stop20h 55mMultiple Airlines
Deal found 12/7$559
This American Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/136:18 pmTYS - SJO
1 stop20h 48mAmerican Airlines
lun. 12/153:38 pmSJO - TYS
1 stop7h 19mAmerican Airlines
Deal found 12/9$582
This Kiwi.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/189:08 amTYS - SAL
1 stop6h 39mMultiple Airlines
mar. 12/235:46 pmSAL - TYS
1 stop21h 29mMultiple Airlines
Deal found 12/8$608
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/229:05 amTYS - PTY
1 stop8h 02mUnited Airlines
lun. 12/294:41 pmPTY - TYS
1 stop18h 30mUnited Airlines
Deal found 12/10$626
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/97:23 pmTYS - SAL
2 stops18h 03mAmerican Airlines
mié. 1/143:21 pmSAL - TYS
2 stops21h 33mAmerican Airlines
Deal found 12/8$644
This Kiwi.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/239:27 pmTYS - GUA
2 stops17h 36mMultiple Airlines
dom. 1/43:00 pmGUA - TYS
1 stop18h 15mMultiple Airlines
Deal found 12/8$652
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/116:00 amTYS - PTY
1 stop9h 42mAmerican Airlines
jue. 12/182:53 pmPTY - TYS
1 stop9h 45mAmerican Airlines
Deal found 12/10$656
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/97:23 pmTYS - SAL
2 stops18h 03mAmerican Airlines
lun. 1/123:49 pmSAL - TYS
1 stop7h 10mAmerican Airlines
Deal found 12/8$664
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/226:25 pmTYS - PTY
2 stops19h 28mAmerican Airlines
lun. 12/294:55 pmPTY - TYS
1 stop7h 43mAmerican Airlines
Deal found 12/8$690

Find flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated diciembre 10, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$341
(Kiwi.com)

One-way from

$201
(American Airlines)

Popular in

April

Cheapest in

October

Average price

$682
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
Search Deals
From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 10, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleManagua

TYS - MGA

TYSMGA

Knoxville McGhee Tyson

vie. 1/9

8:30 am-2:56 pm

1 stop7h 26m

Managua Augusto C Sandino

vie. 1/16

4:02 pm-11:09 am

1 stop18h 07m

$339

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

lun. 2/23

12:55 pm-1:11 pm

2 stops25h 16m

Guatemala City La Aurora

sáb. 2/28

7:10 pm-10:07 pm

1 stop25h 57m

$341

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

lun. 1/12

6:18 pm-11:37 am

1 stop18h 19m

San José Juan Santamaria Intl

jue. 1/22

1:30 pm-10:10 am

2 stops19h 40m

$389

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

jue. 1/22

9:29 am-11:20 am

2 stops26h 51m

Guatemala City La Aurora

jue. 1/29

2:11 pm-5:28 pm

3 stops26h 17m

$392

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

mar. 1/13

7:20 pm-3:50 am

1 stop9h 30m

San José Juan Santamaria Intl

jue. 1/22

9:35 am-7:50 pm

2 stops9h 15m

$418

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

lun. 4/27

5:30 am-12:35 pm

1 stop9h 05m

San Salvador El Salvador Intl

mié. 4/29

2:00 pm-11:46 pm

1 stop7h 46m

$430

KnoxvilleManagua

TYS - MGA

TYSMGA

Knoxville McGhee Tyson

jue. 1/22

6:20 am-9:15 pm

1 stop15h 55m

Managua Augusto C Sandino

jue. 1/29

7:00 am-5:06 pm

1 stop9h 06m

$432

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

lun. 4/27

8:44 pm-10:50 am

2 stops16h 06m

San Salvador El Salvador Intl

mié. 4/29

1:15 pm-11:14 pm

1 stop7h 59m

$434

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

lun. 1/19

6:59 am-7:38 pm

1 stop12h 39m

Panama City Tocumen Intl

lun. 2/2

8:55 am-6:05 pm

1 stop9h 10m

$456

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

jue. 1/22

6:20 am-3:38 pm

1 stop9h 18m

Panama City Tocumen Intl

jue. 1/29

2:27 pm-11:59 pm

1 stop9h 32m

$456

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 49 results
1
2
3
...
5

Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 10, 2025.

One of the essential ways to save on airfare from Knoxville to Central America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 23% on airfare.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated diciembre 10, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,048 reviews
Delta
7.9
Good
8,007 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Central America?

    Departing from Knoxville to Central America will take you 9h 05m. There are 1576 mi between Knoxville and Central America. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - Belize City Philip S.W.Goldson or Knoxville McGhee Tyson - Liberia, Knoxville McGhee Tyson - San José Juan Santamaria Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Central America

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to LaGuardia flights
Nashville to John F Kennedy Intl flights
Nashville to Newark flights
Nashville to Los Angeles flights
Memphis to LaGuardia flights
Nashville to Orlando flights
Nashville to Miami flights
Nashville to Denver flights
Nashville to Seattle flights
Nashville to Fort Lauderdale flights
Nashville to Dallas/Fort Worth flights
Nashville to Las Vegas flights
Memphis to John F Kennedy Intl flights
Nashville to O'Hare Intl flights
Memphis to Las Vegas flights
Nashville to Cancún flights
Memphis to Atlanta flights
Nashville to Tampa flights
Memphis to Orlando flights
Nashville to Heathrow flights
Nashville to Sky Harbor Intl flights
Chattanooga to LaGuardia flights
Nashville to Dulles Intl flights
Memphis to Los Angeles flights
Nashville to Hobby flights
Chattanooga to John F Kennedy Intl flights
Memphis to O'Hare Intl flights
Nashville to San Francisco flights
Nashville to Salt Lake City flights
Memphis to Newark flights
Knoxville to LaGuardia flights
Nashville to Baltimore flights
Nashville to Reagan-National flights
Nashville to Boston flights
Memphis to Dallas/Fort Worth flights
Memphis to Hobby flights
Nashville to Ontario flights
Memphis to Denver flights
Memphis to Miami flights
Nashville to George Bush Intcntl flights
Nashville to New Orleans flights
Chattanooga to Orlando flights
Knoxville to Denver flights
Knoxville to O'Hare Intl flights
Memphis to Sky Harbor Intl flights
Knoxville to Dallas/Fort Worth flights
Nashville to Santa Ana flights
Knoxville to Seattle flights
Nashville to Narita flights
Nashville to Cozumel flights

Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 10, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$605FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$357Average$629FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$783FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.