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Central America

$92+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
Jan 2 — Jan 91
Fri 1/2
Fri 1/9
1 adult, Economy
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Cheap flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 3, 2025.

This Avianca deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:25 pmTYS - SJO
1 stop9h 25mMultiple Airlines
Sun 12/147:50 pmSJO - TYS
2 stops13h 58mMultiple Airlines
Deal found 12/2$461
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:38 pmTYS - SAL
2 stops22h 09mMultiple Airlines
Wed 1/2111:23 amSAL - TYS
2 stops20h 16mMultiple Airlines
Deal found 12/2$472
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:00 amTYS - SAL
1 stop16h 49mAmerican Airlines
Mon 1/123:49 pmSAL - TYS
2 stops18h 42mAmerican Airlines
Deal found 12/1$482
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:24 amTYS - SJO
1 stop16h 47mAmerican Airlines
Thu 12/113:06 pmSJO - TYS
1 stop17h 48mAmerican Airlines
Deal found 12/1$524
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:42 amTYS - PTY
1 stop7h 56mUnited Airlines
Tue 12/2311:35 amPTY - TYS
1 stop12h 07mUnited Airlines
Deal found 12/1$533
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amTYS - SAL
1 stop16h 49mAmerican Airlines
Sun 2/83:49 pmSAL - TYS
2 stops16h 56mAmerican Airlines
Deal found 12/1$538
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:25 pmTYS - SAL
1 stop27h 26mUnited Airlines
Fri 12/126:55 amSAL - TYS
1 stop11h 59mUnited Airlines
Deal found 11/30$545
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:23 pmTYS - SAL
2 stops40h 00mMultiple Airlines
Wed 1/2110:05 pmSAL - TYS
1 stop18h 48mMultiple Airlines
Deal found 12/2$555
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1012:53 pmTYS - SJO
2 stops23h 49mMultiple Airlines
Sat 12/131:31 pmSJO - TYS
1 stop27h 50mMultiple Airlines
Deal found 12/3$562
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:22 pmTYS - SJO
1 stop7h 37mAmerican Airlines
Sun 12/143:38 pmSJO - TYS
1 stop8h 03mAmerican Airlines
Deal found 12/1$565
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/167:23 pmTYS - PTY
2 stops18h 24mAmerican Airlines
Tue 12/232:53 pmPTY - TYS
1 stop9h 45mAmerican Airlines
Deal found 12/1$590
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:02 pmTYS - SJO
2 stops11h 26mAmerican Airlines
Wed 1/146:00 amSJO - TYS
1 stop16h 59mAmerican Airlines
Deal found 12/2$594

Find flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated December 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$268
(Kiwi.com)

One-way from

$92
(Kiwi.com)

Popular in

April

Cheapest in

October

Average price

$682
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
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From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($5 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 3, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sat 1/17

5:59 pm-12:29 pm

1 stop19h 30m

Guatemala City La Aurora

Sat 1/24

1:28 pm-8:39 am

1 stop18h 11m

$268

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Thu 1/22

9:29 am-10:28 am

2 stops25h 59m

San Salvador El Salvador Intl

Sun 1/25

4:02 pm-5:28 pm

2 stops24h 26m

$287

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Thu 1/15

1:39 pm-1:26 pm

2 stops24h 47m

Guatemala City La Aurora

Thu 1/22

1:28 pm-1:40 pm

1 stop23h 12m

$379

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Fri 1/30

7:15 am-4:10 pm

2 stops33h 55m

San José Juan Santamaria Intl

Mon 2/9

1:30 pm-12:10 pm

2 stops21h 40m

$401

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 1/21

4:47 pm-11:37 am

2 stops19h 50m

San José Juan Santamaria Intl

Tue 1/27

12:33 pm-3:57 pm

3 stops26h 24m

$406

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sat 1/17

5:59 pm-11:37 am

2 stops18h 38m

San José Juan Santamaria Intl

Sat 1/24

12:33 pm-8:39 am

2 stops19h 06m

$418

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 2/18

9:10 am-6:55 pm

2 stops10h 45m

San José Juan Santamaria Intl

Mon 2/23

4:15 pm-10:49 am

2 stops17h 34m

$418

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Wed 1/21

2:25 pm-5:00 am

1 stop15h 35m

Guatemala City La Aurora

Sat 1/31

7:10 pm-10:57 am

1 stop14h 47m

$442

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 4/15

11:40 am-6:37 pm

1 stop7h 57m

Panama City Tocumen Intl

Sun 4/19

7:55 am-11:19 pm

1 stop14h 24m

$456

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

Sun 1/25

5:40 am-12:15 pm

1 stop7h 35m

Belize City Philip S.W.Goldson

Thu 1/29

1:40 pm-11:45 pm

1 stop9h 05m

$464

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 52 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 3, 2025.

One of the essential ways to save on airfare from Knoxville to Central America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 26% on airfare.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated December 3, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Overall

7.9

Boarding

8.1

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Overall

7.9

Boarding

8.1

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,063 reviews
Delta
7.9
Good
8,011 reviews

Overall

7.9

Boarding

8.1

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,045 reviews
Delta
7.9
Good
8,011 reviews

Overall

7.9

Boarding

8.1

Entertainment

7.9

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Central America?

    Departing from Knoxville to Central America will take you 7h 35m. There are 1289 mi between Knoxville and Central America. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - Belize City Philip S.W.Goldson or Knoxville McGhee Tyson - San Salvador El Salvador Intl, Knoxville McGhee Tyson - San José Juan Santamaria Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Central America

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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$605FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$357Average$631FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$778FlexibilityNo cancel feeOn-time69%

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