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Central America

$173+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:00 amTYS - SJO
1 stop6h 29mAmerican Airlines
Wed 12/313:29 pmSJO - TYS
1 stop8h 09mAmerican Airlines
Deal found 12/22$586
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:12 pmTYS - PTY
2 stops21h 41mAmerican Airlines
Wed 12/314:55 pmPTY - TYS
1 stop7h 43mAmerican Airlines
Deal found 12/22$640
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:00 amTYS - PTY
1 stop7h 45mUnited Airlines
Mon 12/294:41 pmPTY - TYS
1 stop18h 30mUnited Airlines
Deal found 12/21$656
This Kiwi.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amTYS - GUA
1 stop6h 25mMultiple Airlines
Mon 1/51:39 pmGUA - TYS
1 stop27h 53mMultiple Airlines
Deal found 12/22$702
This American Airlines deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amTYS - GUA
2 stops17h 56mAmerican Airlines
Mon 1/128:20 amGUA - TYS
1 stop7h 34mAmerican Airlines
Deal found 12/23$743
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:30 amTYS - PTY
2 stops29h 23mAmerican Airlines
Thu 1/12:53 pmPTY - TYS
2 stops19h 31mAmerican Airlines
Deal found 12/21$779
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:49 pmTYS - BZE
1 stop17h 26mMultiple Airlines
Sat 12/271:10 pmBZE - TYS
1 stop18h 08mMultiple Airlines
Deal found 12/21$782
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:12 pmTYS - SAL
2 stops21h 25mAmerican Airlines
Thu 1/12:31 pmSAL - TYS
1 stop8h 14mAmerican Airlines
Deal found 12/22$785
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amTYS - PTY
1 stop7h 45mUnited Airlines
Fri 1/24:41 pmPTY - TYS
1 stop18h 30mUnited Airlines
Deal found 12/21$790
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:00 amTYS - SAL
1 stop9h 24mUnited Airlines
Wed 12/312:00 amSAL - TYS
1 stop15h 10mUnited Airlines
Deal found 12/22$824
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:25 pmTYS - PTY
2 stops21h 29mAmerican Airlines
Mon 12/294:55 pmPTY - TYS
1 stop7h 43mAmerican Airlines
Deal found 12/22$830
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/215:35 pmTYS - SJO
1 stop20h 21mUnited Airlines
Sat 1/36:30 amSJO - TYS
1 stop16h 12mUnited Airlines
Deal found 12/21$871

Find flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$376
(Kiwi.com)

One-way from

$173
(Avianca)

Popular in

April

Cheapest in

October

Average price

$682
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
Search Deals
From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Fri 1/23

7:15 am-10:29 am

2 stops28h 14m

San Salvador El Salvador Intl

Fri 1/30

8:45 am-5:28 pm

1 stop7h 43m

$376

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Mon 1/19

12:55 pm-2:52 pm

2 stops26h 57m

San Salvador El Salvador Intl

Mon 1/26

8:45 am-5:28 pm

1 stop7h 43m

$381

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 1/28

4:47 pm-12:22 pm

1 stop20h 35m

San José Juan Santamaria Intl

Fri 1/30

1:30 pm-11:09 am

1 stop20h 39m

$386

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

Thu 2/12

9:32 pm-12:15 pm

1 stop15h 43m

Belize City Philip S.W.Goldson

Mon 2/16

1:28 pm-10:08 am

1 stop19h 40m

$401

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Fri 1/23

6:05 am-2:49 pm

2 stops9h 44m

San Salvador El Salvador Intl

Fri 1/30

1:31 pm-9:45 am

2 stops19h 14m

$402

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Sun 1/18

9:29 am-12:22 pm

1 stop27h 53m

San José Juan Santamaria Intl

Sun 1/25

7:50 pm-5:28 pm

2 stops20h 38m

$413

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sat 2/28

9:40 am-5:00 am

1 stop20h 20m

Guatemala City La Aurora

Sat 3/7

7:10 pm-9:49 am

1 stop13h 39m

$419

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Mon 1/19

6:51 pm-12:31 pm

2 stops18h 40m

San Salvador El Salvador Intl

Mon 1/26

3:49 pm-9:45 am

2 stops16h 56m

$449

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Mon 1/12

7:15 am-11:37 am

3 stops29h 22m

San José Juan Santamaria Intl

Thu 1/22

1:30 pm-12:05 pm

3 stops21h 35m

$453

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 4/18

9:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Wed 4/22

10:00 am-11:41 pm

1 stop12h 41m

$456

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 35 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $456). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

One of the essential ways to save on airfare from Knoxville to Central America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 23% on airfare.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated December 23, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,014 reviews

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,014 reviews
Delta
7.9
Good
8,014 reviews

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,105 reviews
Delta
7.9
Good
8,014 reviews

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,014 reviews

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Central America?

    Departing from Knoxville to Central America will take you 8h 12m. There are 1869 mi between Knoxville and Central America. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - Liberia or Knoxville McGhee Tyson - Belize City Philip S.W.Goldson, Knoxville McGhee Tyson - San José Juan Santamaria Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $456). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Central America

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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$605FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$357Average$638FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$751FlexibilityNo cancel feeOn-time69%

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