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Central America

$135+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
dic. 19 — dic. 261
vie. 12/19
vie. 12/26
1 adult, Economy
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Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 19, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/115:12 pmTYS - BZE
1 stop20h 03mMultiple Airlines
vie. 12/191:10 pmBZE - TYS
1 stop17h 53mMultiple Airlines
Deal found 11/18$406
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/245:31 pmTYS - SAL
1 stop22h 16mMultiple Airlines
mar. 12/303:52 pmSAL - TYS
1 stop24h 25mMultiple Airlines
Deal found 11/17$407
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/245:31 pmTYS - SAL
1 stop22h 16mMultiple Airlines
sáb. 12/272:44 pmSAL - TYS
1 stop16h 34mMultiple Airlines
Deal found 11/17$435
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/306:33 pmTYS - GUA
1 stop19h 01mMultiple Airlines
mié. 1/712:14 pmGUA - TYS
2 stops28h 39mMultiple Airlines
Deal found 11/17$442
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/245:31 pmTYS - SAL
1 stop22h 16mMultiple Airlines
lun. 12/293:52 pmSAL - TYS
1 stop15h 26mMultiple Airlines
Deal found 11/17$448
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/245:31 pmTYS - SAL
1 stop22h 16mMultiple Airlines
mié. 12/3110:40 pmSAL - TYS
1 stop12h 20mMultiple Airlines
Deal found 11/17$457
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/39:10 amTYS - SAL
1 stop13h 09mUnited Airlines
dom. 2/82:50 pmSAL - TYS
1 stop7h 54mUnited Airlines
Deal found 11/18$462
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/306:33 pmTYS - GUA
1 stop19h 01mMultiple Airlines
sáb. 1/108:11 pmGUA - TYS
2 stops20h 42mMultiple Airlines
Deal found 11/17$462
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:00 amTYS - GUA
1 stop9h 03mMultiple Airlines
mié. 1/712:14 pmGUA - TYS
2 stops28h 39mMultiple Airlines
Deal found 11/17$470
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/306:33 pmTYS - GUA
1 stop19h 01mMultiple Airlines
lun. 1/125:10 amGUA - TYS
2 stops11h 18mMultiple Airlines
Deal found 11/17$473
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:00 amTYS - GUA
1 stop9h 03mMultiple Airlines
sáb. 1/108:11 pmGUA - TYS
2 stops20h 42mMultiple Airlines
Deal found 11/17$491
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/83:57 pmTYS - SJO
1 stop7h 23mDelta
jue. 12/117:00 amSJO - TYS
1 stop15h 28mDelta
Deal found 11/18$494

Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated noviembre 19, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$316
(Kiwi.com)

One-way from

$135
(eDestinos)

Popular in

April

Cheapest in

October

Average price

$626
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
Search Deals
From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 19, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

mié. 1/14

4:47 pm-12:24 pm

1 stop20h 37m

Guatemala City La Aurora

vie. 1/23

1:28 pm-11:09 am

1 stop20h 41m

$324

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

lun. 1/12

8:30 am-12:24 pm

1 stop28h 54m

Guatemala City La Aurora

mié. 1/21

1:28 pm-8:39 am

1 stop18h 11m

$324

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

dom. 1/11

1:39 pm-1:31 pm

2 stops24h 52m

Guatemala City La Aurora

sáb. 1/24

1:28 pm-8:39 am

1 stop18h 11m

$339

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

mié. 1/14

4:47 pm-12:24 pm

1 stop20h 37m

Guatemala City La Aurora

mar. 1/20

1:58 pm-3:57 pm

2 stops24h 59m

$348

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

mié. 1/14

4:47 pm-11:20 am

2 stops19h 33m

Guatemala City La Aurora

sáb. 1/24

1:28 pm-8:39 am

1 stop18h 11m

$349

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

lun. 1/12

12:55 pm-11:20 am

1 stop23h 25m

Guatemala City La Aurora

mar. 1/20

1:58 pm-3:57 pm

2 stops24h 59m

$360

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

lun. 4/27

5:30 am-12:35 pm

1 stop9h 05m

San Salvador El Salvador Intl

mié. 4/29

2:00 pm-11:46 pm

1 stop7h 46m

$430

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

lun. 1/12

8:30 am-12:24 pm

1 stop28h 54m

Guatemala City La Aurora

vie. 1/23

5:10 am-5:28 pm

2 stops11h 18m

$431

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

lun. 4/27

6:22 pm-10:50 am

2 stops18h 28m

San Salvador El Salvador Intl

mié. 4/29

2:30 pm-11:47 pm

1 stop7h 17m

$434

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

mié. 12/3

9:10 am-9:19 pm

1 stop13h 09m

San Salvador El Salvador Intl

dom. 2/8

2:50 pm-11:44 pm

1 stop7h 54m

$462

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/16

Showing 1-10 of 54 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 19, 2025.

One of the essential ways to save on airfare from Knoxville to Central America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 26% on airfare.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated noviembre 19, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,004 reviews
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,025 reviews
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,046 reviews
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Overall

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Central America?

    Departing from Knoxville to Central America will take you 9h 05m. There are 1576 mi between Knoxville and Central America. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - San José Juan Santamaria Intl or Knoxville McGhee Tyson - Belize City Philip S.W.Goldson, Knoxville McGhee Tyson - San Salvador El Salvador Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Central America

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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$605FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$382Average$628FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$785FlexibilityNo cancel feeOn-time69%

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