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Central America

$215+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$299
(Kiwi.com)

One-way from

$215
(American Airlines)

Popular in

December

Cheapest in

February

Average price

$560
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
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From Knoxville McGhee Tyson to Central America
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One-way flight from Knoxville McGhee Tyson to Central America
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Highest demand for flights based on searches. 15% potential increase in price ($126 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($47 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/309:03 pmTYS - GUA
1 stop28h 51mMultiple Airlines
Fri 6/612:33 pmGUA - TYS
1 stop18h 01mMultiple Airlines
Deal found 4/30$299
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/146:27 pmTYS - SAL
2 stops19h 42mAmerican Airlines
Wed 5/211:12 pmSAL - TYS
2 stops19h 32mAmerican Airlines
Deal found 4/30$372
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/253:10 pmTYS - SJO
1 stop21h 26mMultiple Airlines
Thu 7/37:30 amSJO - TYS
1 stop24h 41mMultiple Airlines
Deal found 4/30$388
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/145:45 amTYS - SAL
1 stop8h 05mDelta
Wed 5/211:05 pmSAL - TYS
1 stop8h 46mDelta
Deal found 4/30$429
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/277:44 pmTYS - MGA
2 stops18h 58mAmerican Airlines
Tue 6/312:21 pmMGA - TYS
2 stops20h 40mAmerican Airlines
Deal found 4/29$437
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/218:00 amTYS - SJO
2 stops12h 35mAmerican Airlines
Tue 5/2711:59 pmSJO - TYS
2 stops12h 35mAmerican Airlines
Deal found 4/30$457
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/17:54 pmTYS - BZE
2 stops17h 26mAmerican Airlines
Fri 6/611:15 amBZE - TYS
2 stops10h 44mAmerican Airlines
Deal found 4/30$478
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/145:12 pmTYS - PTY
2 stops20h 48mAmerican Airlines
Sat 6/213:20 pmPTY - TYS
2 stops20h 16mAmerican Airlines
Deal found 4/30$480
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:30 amTYS - SJO
1 stop8h 18mDelta
Fri 11/147:00 amSJO - TYS
1 stop7h 05mDelta
Deal found 4/30$484
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/25:45 amTYS - BZE
1 stop8h 03mDelta
Tue 6/171:04 pmBZE - TYS
1 stop8h 55mDelta
Deal found 4/30$504
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/35:30 amTYS - LIR
1 stop8h 30mDelta
Wed 9/101:25 pmLIR - TYS
1 stop8h 21mDelta
Deal found 4/30$507
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/35:14 amTYS - LIR
2 stops9h 47mAmerican Airlines
Wed 9/1012:55 pmLIR - TYS
2 stops19h 23mAmerican Airlines
Deal found 4/30$511

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Fri 5/30

9:03 pm-11:54 pm

1 stop28h 51m

Guatemala City La Aurora

Fri 6/6

12:33 pm-8:34 am

1 stop18h 01m

$299

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Wed 5/14

6:27 pm-12:09 pm

2 stops19h 42m

San Salvador El Salvador Intl

Wed 5/21

1:12 pm-10:44 am

2 stops19h 32m

$372

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 6/25

3:10 pm-10:36 am

1 stop21h 26m

San José Juan Santamaria Intl

Thu 7/3

7:30 am-10:11 am

1 stop24h 41m

$388

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

Wed 5/14

5:45 am-11:50 am

1 stop8h 05m

San Salvador El Salvador Intl

Wed 5/21

1:05 pm-11:51 pm

1 stop8h 46m

$429

KnoxvilleManagua

TYS - MGA

TYSMGA

Knoxville McGhee Tyson

Tue 5/27

7:44 pm-12:42 pm

2 stops18h 58m

Managua Augusto C Sandino

Tue 6/3

12:21 pm-11:01 am

2 stops20h 40m

$437

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 5/21

8:00 am-6:35 pm

2 stops12h 35m

San José Juan Santamaria Intl

Tue 5/27

11:59 pm-2:05 pm

1 stop12h 06m

$457

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

Sun 6/1

7:54 pm-11:20 am

2 stops17h 26m

Belize City Philip S.W.Goldson

Fri 6/6

11:15 am-11:59 pm

2 stops10h 44m

$478

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 6/14

5:12 pm-1:00 pm

2 stops20h 48m

Panama City Tocumen Intl

Sat 6/21

3:20 pm-12:36 pm

2 stops20h 16m

$480

KnoxvilleBelize City

TYS - BZE

TYSBZE

Knoxville McGhee Tyson

Mon 6/2

5:45 am-11:48 am

1 stop8h 03m

Belize City Philip S.W.Goldson

Tue 6/17

1:04 pm-11:59 pm

1 stop8h 55m

$504

KnoxvilleLiberia

TYS - LIR

TYSLIR

Knoxville McGhee Tyson

Wed 9/3

5:30 am-12:00 pm

1 stop8h 30m

Liberia

Wed 9/10

1:25 pm-11:46 pm

1 stop8h 21m

$507

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 30 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Knoxville to Central America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Central America by month

Plan your trip to Central America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Central America ranges from 0.0 - 13.0 inches per month. August is typically the wettest month, when rainfall can reach 13.0 in. February is typically the driest time to visit Central America when rainfall is around 0.0 in.

Temperature in Central America by month

Plan your trip to Central America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Central America, use this chart to help with planning. For those seeking warmer temperatures, March is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated May 1, 2025.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Air Canada
7.0
Good
9,245 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,317 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - San José Juan Santamaria Intl or Knoxville McGhee Tyson - Belize City Philip S.W.Goldson, Knoxville McGhee Tyson - Liberia is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Central America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$558FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$387Average$712FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$388Average$667FlexibilityNo cancel feeOn-time71%

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