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Central America

$138+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
dic. 12 — dic. 191
vie. 12/12
vie. 12/19
1 adult, Economy
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Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on noviembre 12, 2025.

This Mytrip deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/246:32 pmTYS - SJO
1 stop16h 47mMultiple Airlines
lun. 12/812:39 pmSJO - TYS
1 stop8h 10mMultiple Airlines
Deal found 11/11$339
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/77:11 pmTYS - SJO
1 stop18h 14mMultiple Airlines
dom. 12/141:31 pmSJO - TYS
1 stop18h 02mMultiple Airlines
Deal found 11/10$417
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/89:23 amTYS - MGA
1 stop16h 30mMultiple Airlines
dom. 12/141:59 amMGA - TYS
2 stops37h 03mMultiple Airlines
Deal found 11/10$425
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/151:05 pmTYS - SJO
1 stop23h 37mMultiple Airlines
dom. 12/2812:39 pmSJO - TYS
1 stop20h 36mMultiple Airlines
Deal found 11/10$428
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/145:23 pmTYS - SJO
2 stops19h 19mMultiple Airlines
dom. 12/2812:39 pmSJO - TYS
1 stop20h 36mMultiple Airlines
Deal found 11/10$486
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/151:05 pmTYS - SJO
1 stop23h 37mMultiple Airlines
mar. 12/301:31 pmSJO - TYS
1 stop19h 47mMultiple Airlines
Deal found 11/10$494
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/37:38 amTYS - SAL
2 stops15h 11mAmerican Airlines
dom. 2/83:21 pmSAL - TYS
2 stops19h 24mAmerican Airlines
Deal found 11/11$510
This Kiwi.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/151:05 pmTYS - SJO
1 stop23h 37mMultiple Airlines
lun. 12/291:31 pmSJO - TYS
1 stop17h 47mMultiple Airlines
Deal found 11/10$513
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/35:03 pmTYS - SJO
1 stop21h 36mAmerican Airlines
jue. 12/116:20 amSJO - TYS
1 stop16h 30mAmerican Airlines
Deal found 11/10$523
This FlightHub deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/39:40 amTYS - SAL
1 stop11h 15mAvianca
dom. 2/88:25 pmSAL - TYS
1 stop13h 32mAvianca
Deal found 11/12$523
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/125:24 amTYS - BZE
1 stop10h 43mAmerican Airlines
jue. 12/183:11 pmBZE - TYS
1 stop8h 27mAmerican Airlines
Deal found 11/12$524
This Avianca deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/511:42 amTYS - SAL
1 stop8h 58mMultiple Airlines
lun. 1/1212:05 pmSAL - TYS
1 stop10h 39mMultiple Airlines
Deal found 11/11$542

Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated noviembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$310
(Kiwi.com)

One-way from

$138
(Mytrip)

Popular in

April

Cheapest in

October

Average price

$581
Provider with most accurate pricing for Knoxville McGhee Tyson-San Salvador El Salvador Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Salvador El Salvador Intl flights.
Search Deals
From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 12, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

mié. 2/4

4:47 pm-12:24 pm

1 stop20h 37m

Guatemala City La Aurora

sáb. 2/7

1:28 pm-8:39 am

1 stop18h 11m

$310

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

mar. 1/27

7:20 pm-5:00 am

1 stop10h 40m

Guatemala City La Aurora

mar. 2/3

7:10 pm-10:57 am

1 stop14h 47m

$348

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

lun. 1/19

4:23 pm-1:03 pm

2 stops21h 40m

Guatemala City La Aurora

vie. 1/23

1:28 pm-11:09 am

1 stop20h 41m

$383

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

mié. 2/18

3:52 pm-12:22 pm

1 stop21h 30m

San José Juan Santamaria Intl

jue. 2/26

5:00 am-10:07 pm

2 stops16h 07m

$392

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

lun. 2/2

7:20 pm-7:45 am

2 stops13h 25m

San José Juan Santamaria Intl

lun. 2/9

4:15 pm-10:57 am

2 stops17h 42m

$424

KnoxvilleManagua

TYS - MGA

TYSMGA

Knoxville McGhee Tyson

lun. 12/8

9:23 am-12:53 am

1 stop16h 30m

Managua Augusto C Sandino

dom. 12/14

1:59 am-4:02 pm

2 stops37h 03m

$425

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

dom. 2/8

9:29 am-11:37 am

2 stops27h 08m

San José Juan Santamaria Intl

mar. 2/17

4:15 pm-10:49 am

2 stops17h 34m

$425

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

lun. 11/24

6:32 pm-12:15 pm

3 stops42h 43m

San José Juan Santamaria Intl

lun. 12/8

12:39 pm-9:49 pm

1 stop8h 10m

$429

KnoxvilleSan Salvador

TYS - SAL

TYSSAL

Knoxville McGhee Tyson

lun. 4/27

5:30 am-12:35 pm

1 stop9h 05m

San Salvador El Salvador Intl

mié. 4/29

2:00 pm-11:46 pm

1 stop7h 46m

$430

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

mar. 3/10

9:10 am-4:07 pm

1 stop7h 57m

Panama City Tocumen Intl

mar. 3/17

3:41 pm-6:09 pm

1 stop25h 28m

$444

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 47 results
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Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated noviembre 12, 2025.

One of the essential ways to save on airfare from Knoxville to Central America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 26% on airfare.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated noviembre 12, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,009 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,009 reviews
Delta
7.9
Good
8,009 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,015 reviews
Delta
7.9
Good
8,009 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,009 reviews

Overall

7.9

Boarding

8.1

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Central America?

    Departing from Knoxville to Central America will take you 7h 57m. There are 1869 mi between Knoxville and Central America. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - San Salvador El Salvador Intl or Knoxville McGhee Tyson - Managua Augusto C Sandino, Knoxville McGhee Tyson - San José Juan Santamaria Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Central America (average of $86). Flying from Knoxville to Central America in September is currently the most expensive (average of $467). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Central America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated noviembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$605FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$382Average$628FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$785FlexibilityNo cancel feeOn-time69%

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