HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Central America

$183+ Cheap flights from Knoxville (TYS) to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SJO
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Central America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Central America

Keep the following information in mind while searching for Knoxville to Central America flight deals. Data was last updated September 16, 2025.

Round-trip from

$292
(Kiwi.com)

One-way from

$183
(Kiwi.com)
From Knoxville McGhee Tyson to Central America
Search Deals
One-way flight from Knoxville McGhee Tyson to Central America
Search Deals

Find flight deals from Knoxville to Central America

Cheapest flights from Knoxville to Central America
Explore the most affordable flight options available from Knoxville to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/224:26 pmTYS - GUA
1 stop20h 56mMultiple Airlines
Thu 11/61:22 pmGUA - TYS
1 stop8h 11mMultiple Airlines
Deal found 9/16$292
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/224:26 pmTYS - GUA
1 stop20h 56mMultiple Airlines
Tue 11/41:59 amGUA - TYS
1 stop12h 43mMultiple Airlines
Deal found 9/16$300
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:23 amTYS - GUA
2 stops25h 07mMultiple Airlines
Thu 11/61:22 pmGUA - TYS
1 stop8h 11mMultiple Airlines
Deal found 9/16$303
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/224:26 pmTYS - GUA
1 stop20h 56mMultiple Airlines
Mon 11/31:27 pmGUA - TYS
1 stop20h 06mMultiple Airlines
Deal found 9/16$305
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1411:23 amTYS - GUA
2 stops25h 07mMultiple Airlines
Tue 10/2112:27 pmGUA - TYS
1 stop25h 09mMultiple Airlines
Deal found 9/14$306
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:23 amTYS - GUA
1 stop25h 59mMultiple Airlines
Wed 11/51:22 pmGUA - TYS
1 stop18h 42mMultiple Airlines
Deal found 9/16$308
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:23 amTYS - GUA
1 stop25h 59mMultiple Airlines
Mon 11/31:27 pmGUA - TYS
1 stop20h 06mMultiple Airlines
Deal found 9/16$312
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:23 amTYS - GUA
1 stop25h 59mMultiple Airlines
Sun 11/21:27 pmGUA - TYS
1 stop8h 06mMultiple Airlines
Deal found 9/16$316
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2510:53 amTYS - GUA
1 stop26h 29mMultiple Airlines
Tue 11/41:59 amGUA - TYS
1 stop12h 43mMultiple Airlines
Deal found 9/16$319
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/305:24 pmTYS - GUA
2 stops19h 06mMultiple Airlines
Thu 11/61:22 pmGUA - TYS
1 stop8h 11mMultiple Airlines
Deal found 9/15$323
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/13:21 pmTYS - SJO
1 stop21h 06mMultiple Airlines
Mon 10/2012:35 pmSJO - TYS
1 stop19h 58mMultiple Airlines
Deal found 9/15$335
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2912:45 pmTYS - SJO
2 stops24h 29mMultiple Airlines
Fri 10/3112:35 pmSJO - TYS
1 stop19h 28mMultiple Airlines
Deal found 9/15$338

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Knoxville to Central America that are best for you.

Fly from

Knoxville

Fly to

Central America

Route

Depart

Return

Price

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Thu 10/23

9:15 pm-11:22 am

1 stop16h 07m

Guatemala City La Aurora

Wed 11/5

1:22 pm-9:04 am

1 stop18h 42m

$300

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Tue 10/21

11:23 am-10:30 am

2 stops25h 07m

Guatemala City La Aurora

Thu 11/6

1:22 pm-10:33 pm

1 stop8h 11m

$303

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Thu 10/23

9:15 pm-11:22 am

1 stop16h 07m

Guatemala City La Aurora

Mon 11/3

1:27 pm-10:33 am

1 stop20h 06m

$305

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Tue 10/14

11:23 am-10:30 am

2 stops25h 07m

Guatemala City La Aurora

Tue 10/21

12:27 pm-3:36 pm

1 stop25h 09m

$306

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sat 10/25

10:53 am-11:22 am

1 stop26h 29m

Guatemala City La Aurora

Tue 11/4

1:59 am-3:42 pm

1 stop12h 43m

$319

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Thu 10/30

5:24 pm-10:30 am

2 stops19h 06m

Guatemala City La Aurora

Thu 11/6

1:22 pm-10:33 pm

1 stop8h 11m

$323

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Fri 10/17

8:54 pm-11:22 am

1 stop16h 28m

Guatemala City La Aurora

Fri 10/24

12:27 pm-10:03 am

1 stop19h 36m

$324

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Sat 10/25

10:53 am-11:22 am

1 stop26h 29m

Guatemala City La Aurora

Sun 11/2

1:27 pm-10:33 pm

1 stop8h 06m

$327

KnoxvilleGuatemala City

TYS - GUA

TYSGUA

Knoxville McGhee Tyson

Fri 10/24

3:26 pm-11:22 am

1 stop21h 56m

Guatemala City La Aurora

Thu 11/6

1:22 pm-10:33 pm

1 stop8h 11m

$333

KnoxvilleSan José

TYS - SJO

TYSSJO

Knoxville McGhee Tyson

Wed 10/1

3:21 pm-10:27 am

1 stop21h 06m

San José Juan Santamaria Intl

Sun 10/12

12:35 pm-11:18 am

1 stop20h 43m

$395

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 37 results
1
2
3
4

Best time to book a flight from Knoxville to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Central America

What is the cheapest month to book a flight from Knoxville to Central America?

Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $554). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CA?

Find hourly flight availability from Knoxville to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

When flying from Knoxville to Central America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Central America

Get insights into the airlines that provide service to Central America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Central America. Reviews last updated September 16, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Central America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Central America?

    Knoxville McGhee Tyson (TYS) is the airport you will fly out of if you book a flight from Knoxville to Central America. It is only a 11.3 mi journey to McGhee Tyson (TYS) from Knoxville’s city center.

  • How long is the flight from Knoxville to Central America?

    Departing from Knoxville to Central America will take you 11h 35m. There are 1869 mi between Knoxville and Central America. This flight may include one or multiple stops.

  • What are the most popular routes from Knoxville to Central America?

    While some choose either Knoxville McGhee Tyson - Managua Augusto C Sandino or Knoxville McGhee Tyson - Panama City Tocumen Intl, Knoxville McGhee Tyson - San José Juan Santamaria Intl is the most popular route from Knoxville to Central America.

  • Can I find deals for flights from Knoxville to Central America that include hotel bookings?

    Yes. In addition to deals on Knoxville to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Central America.

  • Can I find deals for business class flights from Knoxville to Central America?

    Yes. Cheapflights offers flight deals from Knoxville to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Central America?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to Central America (average of $398). Flying from Knoxville to Central America in March is currently the most expensive (average of $554). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Central America

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to LaGuardia flights
Nashville to John F Kennedy Intl flights
Memphis to Las Vegas flights
Nashville to Sky Harbor Intl flights
Nashville to Newark flights
Nashville to Las Vegas flights
Nashville to Los Angeles flights
Nashville to Denver flights
Memphis to Dallas/Fort Worth flights
Memphis to LaGuardia flights
Knoxville to LaGuardia flights
Memphis to Newark flights
Nashville to Orlando flights
Nashville to Boston flights
Nashville to Hobby flights
Nashville to Seattle flights
Nashville to Dallas/Fort Worth flights
Nashville to Miami flights
Nashville to Fort Lauderdale flights
Nashville to Heathrow flights
Chattanooga to LaGuardia flights
Nashville to Cancún flights
Memphis to John F Kennedy Intl flights
Nashville to George Bush Intcntl flights
Nashville to O'Hare Intl flights
Nashville to Reagan-National flights
Nashville to Salt Lake City flights
Memphis to Boston flights
Nashville to Dulles Intl flights
Memphis to Denver flights
Memphis to Orlando flights
Chattanooga to John F Kennedy Intl flights
Memphis to Atlanta flights
Knoxville to O'Hare Intl flights
Knoxville to Denver flights
Memphis to O'Hare Intl flights
Knoxville to John F Kennedy Intl flights
Memphis to Sky Harbor Intl flights
Nashville to San Francisco flights
Memphis to Hobby flights
Knoxville to Las Vegas flights
Memphis to Los Angeles flights
Memphis to Miami flights
Chattanooga to Newark flights
Nashville to Ontario flights
Nashville to Tampa flights
Nashville to Philadelphia flights
Memphis to Cancún flights
Memphis to Love Field flights
Nashville to Cozumel flights

Top 3 airlines flying from Knoxville to Central America

Discover the top 3 airlines that operate flights from Knoxville to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$269Average$537FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$382Average$659FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$387Average$803FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.