How long is the flight from Knoxville to Syracuse?

Airlines like Delta and American Airlines fly from Knoxville to Syracuse in about 4h 04m. The time it takes to get you to your destination can typically vary by up to 1h 33m. Knoxville and Syracuse are separated by a distance of 656 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Knoxville to Syracuse round-trip?

According to our current data, Delta ($232), and American Airlines ($238) offers the cheapest pricing from Knoxville to Syracuse. You may be able to fly from Knoxville to Syracuse for 28% less than the average price by searching for these airlines.

In terms of precipitation, rainfall in Syracuse ranges from 2.1 - 3.8 inches per month. July is typically the wettest month, when rainfall can reach 3.8 in. February is typically the driest time to visit Syracuse when rainfall is around 2.1 in.

If weather is an important factor for your trip to Syracuse, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Most accurate provider : When it comes to deals on Knoxville-Syracuse flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Syracuse flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Syracuse flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-Syracuse flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to Syracuse that include hotel bookings?

Yes. In addition to deals on Knoxville to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Syracuse?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Syracuse.

Can I find deals for business class flights from Knoxville to Syracuse?

Yes. Cheapflights offers flight deals from Knoxville to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$124+ Flights from Knoxville to Syracuse

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Cheap flight deals from Knoxville to Syracuse

Cheapest flights from Knoxville to Syracuse
Explore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Sat 12/275:42 amTYS - SYR

1 stop6h 03mAmerican Airlines

Fri 1/27:05 amSYR - TYS

1 stop5h 47mAmerican Airlines

Deal found 12/26

$354

Best flights from Knoxville to Syracuse
Discover carefully curated flight deals from Knoxville to Syracuse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.

Thu 1/229:29 amTYS - SYR

1 stop8h 24mMultiple Airlines

Mon 1/2612:02 pmSYR - TYS

2 stops8h 34mMultiple Airlines

Deal found 12/26

$262

Wed 4/85:30 amTYS - SYR

1 stop5h 37mDelta

Sat 4/116:17 pmSYR - TYS

1 stop5h 34mDelta

Deal found 12/26

$269

Fri 1/2310:11 amTYS - SYR

1 stop4h 04mAmerican Airlines

Fri 1/303:03 pmSYR - TYS

1 stop5h 53mAmerican Airlines

Deal found 12/26

$269

Mon 1/266:45 amTYS - SYR

2 stops7h 22mUnited Airlines

Mon 2/210:19 amSYR - TYS

2 stops10h 33mUnited Airlines

Deal found 12/27

$295

Fri 1/236:10 amTYS - SYR

1 stop5h 27mDelta

Thu 2/56:15 amSYR - TYS

1 stop4h 57mDelta

Deal found 12/26

$269

Mon 1/266:00 amTYS - SYR

1 stop5h 26mAmerican Airlines

Mon 2/22:15 pmSYR - TYS

2 stops7h 29mAmerican Airlines

Deal found 12/27

$274

Mon 1/266:10 amTYS - SYR

1 stop5h 27mDelta

Mon 2/24:32 pmSYR - TYS

1 stop4h 15mDelta

Deal found 12/27

$269

Thu 1/224:00 pmTYS - SYR

2 stops7h 40mAmerican Airlines

Mon 1/262:15 pmSYR - TYS

2 stops7h 29mAmerican Airlines

Deal found 12/26

$279

Sat 2/149:13 amTYS - SYR

1 stop3h 53mAmerican Airlines

Mon 2/164:11 pmSYR - TYS

1 stop5h 37mAmerican Airlines

Deal found 12/26

$294

Fri 1/236:05 amTYS - SYR

2 stops7h 45mAmerican Airlines

Thu 2/55:09 amSYR - TYS

2 stops8h 45mAmerican Airlines

Deal found 12/26

$314

Last-minute flights from Knoxville to Syracuse
Discover last-minute flight deals from Knoxville to Syracuse. Data last updated December 28, 2025 and is based on user searches.

Sat 12/275:42 amTYS - SYR

1 stop6h 03mAmerican Airlines

Fri 1/27:05 amSYR - TYS

1 stop5h 47mAmerican Airlines

Deal found 12/26

$354

Sun 1/186:00 amTYS - SYR

1 stop5h 26mAmerican Airlines

Sun 1/255:18 pmSYR - TYS

1 stop4h 26mAmerican Airlines

Deal found 12/26

$319

Sun 1/181:39 pmTYS - SYR

2 stops19h 57mMultiple Airlines

Sun 1/258:04 pmSYR - TYS

1 stop19h 15mMultiple Airlines

Deal found 12/26

$336

Thu 1/229:29 amTYS - SYR

1 stop8h 24mMultiple Airlines

Mon 1/2612:02 pmSYR - TYS

2 stops8h 34mMultiple Airlines

Deal found 12/26

$262

Thu 1/229:29 amTYS - SYR

1 stop8h 24mAllegiant Air

Mon 1/2610:26 amSYR - TYS

1 stop12h 02mAllegiant Air

Deal found 12/26

$265

Thu 1/224:00 pmTYS - SYR

2 stops7h 40mAmerican Airlines

Mon 1/262:15 pmSYR - TYS

2 stops7h 29mAmerican Airlines

Deal found 12/26

$279

Fri 1/236:10 amTYS - SYR

1 stop5h 27mDelta

Thu 2/56:15 amSYR - TYS

1 stop4h 57mDelta

Deal found 12/26

$269

Fri 1/234:00 pmTYS - SYR

2 stops7h 44mAmerican Airlines

Thu 2/55:09 amSYR - TYS

1 stop5h 40mAmerican Airlines

Deal found 12/26

$274

Mon 1/266:45 amTYS - SYR

2 stops7h 22mUnited Airlines

Mon 2/210:19 amSYR - TYS

2 stops10h 33mUnited Airlines

Deal found 12/27

$295

Fri 1/306:45 amTYS - SYR

2 stops7h 22mUnited Airlines

Mon 2/22:42 pmSYR - TYS

1 stop4h 45mUnited Airlines

Deal found 12/25

$344

One-way flights from Knoxville to Syracuse
Search for one-way flight options from Knoxville to Syracuse. Find affordable one-way fares based on user searches. Data last updated December 28, 2025.

Wed 1/73:53 pmTYS - SYR

1 stop18h 25mAllegiant Air

Deal found 12/28

$124

Wed 1/73:53 pmTYS - SYR

2 stops43h 29mMultiple Airlines

Deal found 12/28

$204

Find flight deals from Knoxville to Syracuse

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$262 (Kiwi.com)
One-way from	$124 (Kiwi.com)
Popular in	December
Cheapest in	April
Average price	$469

Provider with most accurate pricing for Knoxville McGhee Tyson-Syracuse Hancock Intl flight deals.

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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Syracuse Hancock Intl flights.

Search Deals

From Knoxville McGhee Tyson to Syracuse Hancock Intl

Search Deals

One-way flight from Knoxville McGhee Tyson to Syracuse Hancock Intl

Search Deals

Highest demand for flights based on searches. 6% potential increase in price ($24 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($13 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 1/22

9:29 am-5:53 pm

1 stop8h 24m

Syracuse Hancock Intl

Mon 1/26

12:02 pm-8:36 pm

2 stops8h 34m

$262

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 4/8

5:30 am-11:07 am

1 stop5h 37m

Syracuse Hancock Intl

Sat 4/11

6:17 pm-11:51 pm

1 stop5h 34m

$269

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 1/23

10:11 am-2:15 pm

1 stop4h 04m

Syracuse Hancock Intl

Fri 1/30

3:03 pm-8:56 pm

1 stop5h 53m

$269

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 1/23

6:10 am-11:37 am

1 stop5h 27m

Syracuse Hancock Intl

Thu 2/5

6:15 am-11:12 am

1 stop4h 57m

$269

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Mon 1/26

6:10 am-11:37 am

1 stop5h 27m

Syracuse Hancock Intl

Mon 2/2

4:32 pm-8:47 pm

1 stop4h 15m

$269

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Mon 1/26

6:00 am-11:26 am

1 stop5h 26m

Syracuse Hancock Intl

Mon 2/2

2:15 pm-9:44 pm

2 stops7h 29m

$274

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 1/22

4:00 pm-11:40 pm

2 stops7h 40m

Syracuse Hancock Intl

Mon 1/26

2:15 pm-9:44 pm

2 stops7h 29m

$279

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 2/14

9:13 am-1:06 pm

1 stop3h 53m

Syracuse Hancock Intl

Mon 2/16

4:11 pm-9:48 pm

1 stop5h 37m

$294

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Mon 1/26

6:45 am-2:07 pm

2 stops7h 22m

Syracuse Hancock Intl

Mon 2/2

10:19 am-8:52 pm

2 stops10h 33m

$295

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 1/23

6:05 am-1:50 pm

2 stops7h 45m

Syracuse Hancock Intl

Thu 2/5

5:09 am-1:54 pm

2 stops8h 45m

$314

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/28

Showing 1-10 of 12 results

Compare providers for flights from Knoxville to Syracuse

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Syracuse in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-Syracuse flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Syracuse flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Syracuse flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-Syracuse flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Syracuse

What is the cheapest month to book a flight from Knoxville to Syracuse?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $160). Flying from Knoxville to Syracuse in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SYR?

It’s typically best to fly out from Knoxville to Syracuse in the morning. Doing so could potentially save you 23% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Syracuse

Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Syracuse. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Delta

7.9

Good

8,019 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

American Airlines

7.2

Good

11,072 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

10.0

Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

How long is the flight from Knoxville to Syracuse?
Airlines like Delta and American Airlines fly from Knoxville to Syracuse in about 4h 04m. The time it takes to get you to your destination can typically vary by up to 1h 33m. Knoxville and Syracuse are separated by a distance of 656 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Knoxville to Syracuse round-trip?
According to our current data, Delta ($232), and American Airlines ($238) offers the cheapest pricing from Knoxville to Syracuse. You may be able to fly from Knoxville to Syracuse for 28% less than the average price by searching for these airlines.
Can I find deals for flights from Knoxville to Syracuse that include hotel bookings?
Yes. In addition to deals on Knoxville to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Syracuse?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Syracuse.
Can I find deals for business class flights from Knoxville to Syracuse?
Yes. Cheapflights offers flight deals from Knoxville to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Syracuse?
Currently, April is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $160). Flying from Knoxville to Syracuse in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

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Other flights to Syracuse

Top 2 airlines flying from Knoxville to Syracuse

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$232	Average$318	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$238	Average$334	FlexibilityNo cancel fee	On-time71%

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$124+ Cheap flights from Knoxville to Syracuse (TYS - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Knoxville to Syracuse

Cheapest flights from Knoxville to SyracuseExplore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Explore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Find flight deals from Knoxville to Syracuse

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Compare providers for flights from Knoxville to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Syracuse in December.

Best time to book a flight from Knoxville to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Syracuse

What is the cheapest month to book a flight from Knoxville to Syracuse?

What is the cheapest time of day to fly from TYS to SYR?

Reviews of airlines servicing Syracuse

Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Syracuse. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Knoxville to Syracuse?

What are the cheapest airlines flying from Knoxville to Syracuse round-trip?

Can I find deals for flights from Knoxville to Syracuse that include hotel bookings?

How can I find direct flights from Knoxville to Syracuse?

Can I find deals for business class flights from Knoxville to Syracuse?

What is the cheapest month to book a flight from Knoxville to Syracuse?

Traveling to a place near Syracuse?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Knoxville to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Knoxville to Syracuse

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Cheapest flights from Knoxville to Syracuse
Explore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.