HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Syracuse

$126+ Cheap flights from Knoxville to Syracuse (TYS - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SYR
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Syracuse with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$249
(United Airlines)

One-way from

$126
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$405
From Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($50 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Knoxville to Syracuse

Cheapest flights from Knoxville to Syracuse
Explore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/273:10 pmTYS - SYR
1 stop4h 51mAmerican Airlines
Tue 11/1111:40 amSYR - TYS
1 stop5h 40mAmerican Airlines
Deal found 8/13$249
This Mytrip deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/208:55 pmTYS - SYR
1 stop13h 19mMultiple Airlines
Sun 9/216:10 pmSYR - TYS
2 stops17h 45mMultiple Airlines
Deal found 8/14$267
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/55:20 pmTYS - SYR
1 stop6h 20mAmerican Airlines
Fri 9/126:47 pmSYR - TYS
1 stop4h 16mAmerican Airlines
Deal found 8/13$304
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1510:36 amTYS - SYR
1 stop6h 34mAmerican Airlines
Fri 8/295:35 pmSYR - TYS
1 stop4h 26mAmerican Airlines
Deal found 8/13$324
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/115:45 amTYS - SYR
1 stop3h 58mUnited Airlines
Thu 9/186:00 amSYR - TYS
2 stops8h 40mUnited Airlines
Deal found 8/13$345
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/45:19 pmTYS - SYR
1 stop4h 43mAmerican Airlines
Sat 10/116:00 amSYR - TYS
1 stop4h 13mAmerican Airlines
Deal found 8/13$433

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Fly from

Knoxville

Fly to

Syracuse

Route

Depart

Return

Price

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 9/20

10:54 am-4:46 pm

1 stop5h 52m

Syracuse Hancock Intl

Sun 9/21

6:10 am-10:28 am

1 stop4h 18m

$249

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 9/27

3:10 pm-8:01 pm

1 stop4h 51m

Syracuse Hancock Intl

Tue 11/11

6:12 pm-10:51 pm

1 stop4h 39m

$249

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 9/20

8:55 pm-10:14 am

1 stop13h 19m

Syracuse Hancock Intl

Sun 9/21

6:10 pm-11:55 am

2 stops17h 45m

$267

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 9/11

6:30 am-11:00 am

1 stop4h 30m

Syracuse Hancock Intl

Thu 9/18

7:38 pm-12:07 am

1 stop4h 29m

$304

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 10/7

7:00 am-11:58 am

1 stop4h 58m

$126

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 10/7

7:00 am-2:14 pm

2 stops7h 14m

$166

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sun 10/12

7:00 am-11:58 am

1 stop4h 58m

$239

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sun 10/12

9:50 pm-10:17 am

3 stops36h 27m

$276

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Best time to book a flight from Knoxville to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Syracuse

What is the cheapest month to book a flight from Knoxville to Syracuse?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $272). Flying from Knoxville to Syracuse in July is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SYR?

Find hourly flight availability from Knoxville to Syracuse. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

It’s typically best to fly out from Knoxville to Syracuse in the morning. Doing so could potentially save you 24% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated August 14, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Syracuse. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Comfort

7.9

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Syracuse round-trip?

    According to our current data, Delta ($216), United Airlines ($223), and American Airlines ($228) offers the cheapest pricing from Knoxville to Syracuse. You may be able to fly from Knoxville to Syracuse for 34% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Syracuse that include hotel bookings?

    Yes. In addition to deals on Knoxville to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Syracuse.

  • Can I find deals for business class flights from Knoxville to Syracuse?

    Yes. Cheapflights offers flight deals from Knoxville to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Syracuse?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $272). Flying from Knoxville to Syracuse in July is currently the most expensive (average of $385). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Liverpool
Cicero
East Syracuse
Waterloo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to LaGuardia flights
Nashville to John F Kennedy Intl flights
Nashville to Newark flights
Memphis to LaGuardia flights
Memphis to Newark flights
Chattanooga to LaGuardia flights
Memphis to John F Kennedy Intl flights
Chattanooga to John F Kennedy Intl flights
Knoxville to LaGuardia flights
Knoxville to John F Kennedy Intl flights
Knoxville to Newark flights
Nashville to Buffalo flights
Chattanooga to Newark flights
Nashville to White Plains flights
Nashville to Syracuse flights
Memphis to Syracuse flights
Nashville to Albany flights
Memphis to Buffalo flights
Memphis to Albany flights
Nashville to Stewart flights
Knoxville to Albany flights
Blountville to John F Kennedy Intl flights
Knoxville to Buffalo flights
Blountville to LaGuardia flights
Nashville to Rochester flights
Blountville to Newark flights
Nashville to Ithaca flights
Knoxville to Rochester flights
Memphis to Stewart flights
Chattanooga to White Plains flights
Chattanooga to Syracuse flights
Memphis to Binghamton flights
Chattanooga to Buffalo flights
Knoxville to Stewart flights
Memphis to White Plains flights
Memphis to Rochester flights
Nashville to Binghamton flights
Nashville to Elmira flights
Chattanooga to Albany flights
Blountville to Buffalo flights
Nashville to Islip flights
Knoxville to White Plains flights
Chattanooga to Rochester flights
Blountville to Syracuse flights
Knoxville to Binghamton flights
Blountville to Albany flights
Knoxville to Islip flights
Chattanooga to Islip flights
Chattanooga to Elmira flights

Top 3 airlines flying from Knoxville to Syracuse

Discover the top 3 airlines that operate flights from Knoxville to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$325FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$413FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$228Average$341FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.