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Syracuse

$201+ Cheap flights from Knoxville to Syracuse (TYS - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SYR
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Find flight deals from Knoxville to Syracuse

Cheapest flights from Knoxville to Syracuse
Explore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:35 amTYS - SYR
1 stop5h 33mDelta
Tue 12/27:01 pmSYR - TYS
1 stop4h 29mDelta
Deal found 11/11$249
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:25 pmTYS - SYR
1 stop5h 41mDelta
Wed 12/312:58 pmSYR - TYS
1 stop7h 02mDelta
Deal found 11/11$251
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:12 amTYS - SYR
1 stop5h 38mAmerican Airlines
Tue 12/23:14 pmSYR - TYS
2 stops7h 37mAmerican Airlines
Deal found 11/11$254
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:12 amTYS - SYR
1 stop5h 38mAmerican Airlines
Wed 12/33:24 pmSYR - TYS
2 stops7h 31mAmerican Airlines
Deal found 11/11$256
This American Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:05 amTYS - SYR
2 stops6h 35mAmerican Airlines
Sun 12/76:08 amSYR - TYS
2 stops7h 01mAmerican Airlines
Deal found 11/13$274
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/265:51 pmTYS - SYR
1 stop6h 28mAmerican Airlines
Tue 12/23:57 pmSYR - TYS
1 stop6h 54mAmerican Airlines
Deal found 11/11$294
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:30 amTYS - SYR
1 stop25h 13mAllegiant Air
Wed 12/172:43 pmSYR - TYS
2 stops31h 13mAllegiant Air
Deal found 11/11$329
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:30 amTYS - SYR
1 stop6h 22mAmerican Airlines
Tue 12/25:30 amSYR - TYS
1 stop5h 22mAmerican Airlines
Deal found 11/12$349
This Mytrip deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:20 amTYS - SYR
1 stop10h 11mMultiple Airlines
Sun 12/79:55 pmSYR - TYS
3 stops23h 54mMultiple Airlines
Deal found 11/13$364
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:35 amTYS - SYR
1 stop5h 33mDelta
Sun 11/167:01 pmSYR - TYS
1 stop4h 40mDelta
Deal found 11/11$369
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:26 amTYS - SYR
2 stops10h 27mUnited Airlines
Sun 11/165:45 amSYR - TYS
1 stop5h 03mUnited Airlines
Deal found 11/11$374

Cheap flight deals from Knoxville to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(United Airlines)

One-way from

$201
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$338
Provider with most accurate pricing for Knoxville McGhee Tyson-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Syracuse Hancock Intl flights.
Search Deals
From Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($31 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Fly from

Knoxville

Fly to

Syracuse

Route

Depart

Return

Price

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Mon 11/24

6:10 am-11:36 am

1 stop5h 26m

Syracuse Hancock Intl

Tue 12/2

12:58 pm-8:00 pm

1 stop7h 02m

$249

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 1/7

11:10 am-4:15 pm

1 stop5h 05m

Syracuse Hancock Intl

Sun 1/11

5:48 am-10:57 am

1 stop5h 09m

$249

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 12/5

5:40 am-11:13 am

1 stop5h 33m

Syracuse Hancock Intl

Sun 12/7

6:00 am-11:47 am

1 stop5h 47m

$249

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 1/7

11:10 am-4:15 pm

1 stop5h 05m

Syracuse Hancock Intl

Sat 1/10

5:48 am-10:57 am

1 stop5h 09m

$249

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 12/6

7:30 am-12:08 pm

1 stop4h 38m

Syracuse Hancock Intl

Sun 12/7

6:00 am-11:47 am

1 stop5h 47m

$249

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 12/2

6:12 am-11:50 am

1 stop5h 38m

Syracuse Hancock Intl

Wed 12/3

5:12 am-10:33 am

1 stop5h 21m

$251

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 12/2

5:25 pm-11:06 pm

1 stop5h 41m

Syracuse Hancock Intl

Wed 12/3

12:58 pm-8:00 pm

1 stop7h 02m

$251

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 1/7

6:00 am-11:26 am

1 stop5h 26m

Syracuse Hancock Intl

Sat 1/10

6:00 am-3:20 pm

2 stops9h 20m

$254

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 12/5

10:55 am-2:59 pm

1 stop4h 04m

Syracuse Hancock Intl

Sun 12/7

6:08 am-1:09 pm

2 stops7h 01m

$254

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 1/7

7:44 am-1:50 pm

1 stop6h 06m

Syracuse Hancock Intl

Sun 1/11

2:15 pm-9:44 pm

2 stops7h 29m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 14 results
1
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Compare providers for flights from Knoxville to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Syracuse in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Syracuse flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Syracuse flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Syracuse flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Syracuse

What is the cheapest month to book a flight from Knoxville to Syracuse?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $160). Flying from Knoxville to Syracuse in November is currently the most expensive (average of $256). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SYR?

Find hourly flight availability from Knoxville to Syracuse. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

It’s typically best to fly out from Knoxville to Syracuse in the morning. Doing so could potentially save you 23% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated November 13, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Syracuse. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Food

7.3

Comfort

7.9

Boarding

8.1

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Syracuse?

    Airlines like Delta and United Airlines fly from Knoxville to Syracuse in about 5h 05m. The time it takes to get you to your destination can typically vary by up to 21m. Knoxville and Syracuse are separated by a distance of 656 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Syracuse round-trip?

    According to our current data, Delta ($216), American Airlines ($246), and United Airlines ($253) offers the cheapest pricing from Knoxville to Syracuse. You may be able to fly from Knoxville to Syracuse for 34% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Knoxville to Syracuse one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $201. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Knoxville to Syracuse for a low price.

  • Can I find deals for flights from Knoxville to Syracuse that include hotel bookings?

    Yes. In addition to deals on Knoxville to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Syracuse.

  • Can I find deals for business class flights from Knoxville to Syracuse?

    Yes. Cheapflights offers flight deals from Knoxville to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Syracuse?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $160). Flying from Knoxville to Syracuse in November is currently the most expensive (average of $256). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Liverpool
East Syracuse
Waterloo

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Top 3 airlines flying from Knoxville to Syracuse

Discover the top 3 airlines that operate flights from Knoxville to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$318FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$246Average$338FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$253Average$439FlexibilityNo cancel feeOn-time69%

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