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Syracuse

$161+ Cheap flights from Knoxville to Syracuse (TYS - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SYR
Apr 25 — May 21
Sat 4/25
Sat 5/2
1 adult, Economy
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Cheap flight deals from Knoxville to Syracuse

Cheapest flights from Knoxville to Syracuse
Explore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:02 pm
TYS
-
SYR
1 stop29h 34m
Allegiant Air
Mon 6/1511:38 am
SYR
-
TYS
1 stop28h 34m
Allegiant Air
Deal found 3/23$232
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:35 pm
TYS
-
SYR
1 stop19h 06m
Allegiant Air
Mon 4/2710:29 am
SYR
-
TYS
1 stop28h 29m
Allegiant Air
Deal found 3/22$239
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:32 pm
TYS
-
SYR
1 stop13h 09m
Allegiant Air
Sun 4/266:03 pm
SYR
-
TYS
1 stop18h 22m
Allegiant Air
Deal found 3/22$256
This Kiwi.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:02 pm
TYS
-
SYR
1 stop29h 34m
Multiple Airlines
Mon 6/157:25 pm
SYR
-
TYS
2 stops20h 47m
Multiple Airlines
Deal found 3/23$292
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:32 pm
TYS
-
SYR
1 stop13h 09m
Multiple Airlines
Sun 4/266:03 pm
SYR
-
TYS
2 stops23h 27m
Multiple Airlines
Deal found 3/22$297
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:58 pm
TYS
-
SYR
1 stop7h 13m
American Airlines
Mon 5/116:15 pm
SYR
-
TYS
1 stop5h 40m
American Airlines
Deal found 3/23$310
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:35 pm
TYS
-
SYR
1 stop5h 34m
Delta
Sun 6/146:00 am
SYR
-
TYS
1 stop5h 01m
Delta
Deal found 3/25$329
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:05 am
TYS
-
SYR
1 stop5h 28m
American Airlines
Sat 4/115:46 pm
SYR
-
TYS
1 stop6h 09m
American Airlines
Deal found 3/23$339

Find flight deals from Knoxville to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$232
(Kiwi.com)

One-way from

$161
(Kiwi.com)

Popular in

February

Cheapest in

April

Average price

$338
Provider with most accurate pricing for Knoxville McGhee Tyson-Syracuse Hancock Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Syracuse Hancock Intl flights.
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From Knoxville McGhee Tyson to Syracuse Hancock Intl
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One-way flight from Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($107 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 6/10

1:02 pm-6:36 pm

1 stop29h 34m

Syracuse Hancock Intl

Mon 6/15

11:38 am-4:12 pm

1 stop28h 34m

$232

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 6/10

1:02 pm-6:36 pm

1 stop29h 34m

Syracuse Hancock Intl

Mon 6/15

7:25 pm-4:12 pm

2 stops20h 47m

$292

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 4/23

9:32 pm-10:41 am

1 stop13h 09m

Syracuse Hancock Intl

Sun 4/26

6:03 pm-5:30 pm

2 stops23h 27m

$303

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 6/10

5:35 pm-11:09 pm

1 stop5h 34m

Syracuse Hancock Intl

Sun 6/14

6:00 am-11:09 am

1 stop5h 09m

$329
Quickest round-trip

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 4/9

6:38 pm-11:10 pm

1 stop4h 32m

Syracuse Hancock Intl

Mon 4/13

5:30 am-11:01 am

1 stop5h 31m

$339

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 5/15

6:00 am-11:33 am

1 stop5h 33m

Syracuse Hancock Intl

Mon 5/18

6:58 pm-11:56 pm

1 stop4h 58m

$339

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 6/10

11:02 am-5:24 pm

1 stop6h 22m

Syracuse Hancock Intl

Mon 6/15

6:00 am-11:01 am

1 stop5h 01m

$364

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Thu 4/9

1:52 pm-11:50 pm

2 stops9h 58m

Syracuse Hancock Intl

Mon 4/13

6:00 am-10:50 am

1 stop4h 50m

$431

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 8/26

6:30 am-2:09 pm

2 stops7h 39m

Syracuse Hancock Intl

Sat 8/29

6:00 am-10:36 am

1 stop4h 36m

$502
Cheapest one-way

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 4/4

9:00 am-10:09 am

1 stop25h 09m

$258

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Syracuse in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Syracuse

What is the cheapest month to book a flight from Knoxville to Syracuse?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $160). Flying from Knoxville to Syracuse in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Syracuse?

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated March 26, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Knoxville to Syracuse. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,331 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
7.9
Good
8,331 reviews
Delta
7.9
Good
8,331 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.1
Good
11,495 reviews
Delta
7.9
Good
8,331 reviews

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Syracuse?

    Airlines like Allegiant Air and Delta fly from Knoxville to Syracuse in about 5h 34m. The time it takes to get you to your destination can typically vary by up to 24h. Knoxville and Syracuse are separated by a distance of 656 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Syracuse round-trip?

    According to our current data, Delta ($216), and American Airlines ($238) offers the cheapest pricing from Knoxville to Syracuse. You may be able to fly from Knoxville to Syracuse for 36% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Syracuse that include hotel bookings?

    Yes. In addition to deals on Knoxville to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Syracuse.

  • Can I find deals for business class flights from Knoxville to Syracuse?

    Yes. Cheapflights offers flight deals from Knoxville to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Syracuse?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $160). Flying from Knoxville to Syracuse in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
East Syracuse
Liverpool
Waterloo

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Knoxville to Syracuse

Discover the top 2 airlines that operate flights from Knoxville to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$322FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$238Average$338FlexibilityNo cancel feeOn-time71%

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