HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Syracuse

$108+ Cheap flights from Knoxville to Syracuse (TYS - SYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SYR
Oct 25 — Nov 11
Sat 10/25
Sat 11/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Syracuse with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Syracuse

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Syracuse (SYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 25, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$217
(Delta)

One-way from

$108
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$356
Provider with most accurate pricing for Knoxville McGhee Tyson-Syracuse Hancock Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Syracuse Hancock Intl flights.
Search Deals
From Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Syracuse Hancock Intl
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($44 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Knoxville to Syracuse

Cheapest flights from Knoxville to Syracuse
Explore the most affordable flight options available from Knoxville to Syracuse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2025.

This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:45 amTYS - SYR
1 stop3h 58mUnited Airlines
Mon 11/247:50 pmSYR - TYS
1 stop4h 09mUnited Airlines
Deal found 9/24$225
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:38 amTYS - SYR
1 stop26h 47mMultiple Airlines
Sun 10/197:22 pmSYR - TYS
1 stop14h 34mMultiple Airlines
Deal found 9/24$253
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/257:00 amTYS - SYR
1 stop4h 58mUnited Airlines
Sat 11/17:50 pmSYR - TYS
1 stop4h 09mUnited Airlines
Deal found 9/25$268
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/108:37 pmTYS - SYR
1 stop3h 43mAmerican Airlines
Tue 10/141:44 pmSYR - TYS
1 stop7h 00mAmerican Airlines
Deal found 9/25$279
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:08 pmTYS - SYR
1 stop5h 51mDelta
Tue 11/1112:16 pmSYR - TYS
1 stop4h 30mDelta
Deal found 9/24$294
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/275:05 amTYS - SYR
2 stops6h 26mAmerican Airlines
Tue 11/115:30 amSYR - TYS
1 stop5h 22mAmerican Airlines
Deal found 9/23$299

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Syracuse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from Knoxville to Syracuse that are best for you.

Fly from

Knoxville

Fly to

Syracuse

Route

Depart

Return

Price

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Tue 11/18

5:45 am-9:43 am

1 stop3h 58m

Syracuse Hancock Intl

Mon 11/24

7:50 pm-11:59 pm

1 stop4h 09m

$225

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 10/17

8:38 am-11:25 am

1 stop26h 47m

Syracuse Hancock Intl

Sun 10/19

7:22 pm-9:56 am

1 stop14h 34m

$253

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Sat 10/25

7:00 am-11:58 am

1 stop4h 58m

Syracuse Hancock Intl

Sat 11/1

7:50 pm-11:59 pm

1 stop4h 09m

$268

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 10/10

8:37 pm-12:20 am

1 stop3h 43m

Syracuse Hancock Intl

Tue 10/14

1:44 pm-8:44 pm

1 stop7h 00m

$279

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 10/10

8:37 pm-12:20 am

1 stop3h 43m

Syracuse Hancock Intl

Mon 10/13

5:30 am-9:32 am

1 stop4h 02m

$299

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 10/10

8:38 am-11:25 am

1 stop26h 47m

Syracuse Hancock Intl

Sun 10/12

7:35 pm-11:18 am

1 stop15h 43m

$328

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 10/29

8:15 am-2:49 pm

2 stops6h 34m

$131

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 10/10

7:02 pm-10:17 am

2 stops39h 15m

$146

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Fri 11/7

6:12 pm-10:12 am

2 stops40h 00m

$184

KnoxvilleSyracuse

TYS - SYR

TYSSYR

Knoxville McGhee Tyson

Wed 10/29

4:26 pm-6:59 pm

3 stops26h 33m

$222

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/23

Showing 1-10 of 13 results
1
2

Compare providers for flights from Knoxville to Syracuse

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Syracuse in September.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Syracuse flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Syracuse flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Syracuse flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Syracuse flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Syracuse flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Syracuse

Have a flexible travel schedule? Discover the best time to fly to Syracuse from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Syracuse

What is the cheapest month to book a flight from Knoxville to Syracuse?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $272). Flying from Knoxville to Syracuse in July is currently the most expensive (average of $387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SYR?

Find hourly flight availability from Knoxville to Syracuse. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 25, 2025.

It’s typically best to fly out from Knoxville to Syracuse in the morning. Doing so could potentially save you 24% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Syracuse

Get insights into the airlines that provide service to Syracuse. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Syracuse. Reviews last updated September 25, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Knoxville to Syracuse. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,973 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Comfort

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Syracuse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Syracuse?

    Airlines like United Airlines fly from Knoxville to Syracuse in about 3h 58m. The time it takes to get you to your destination can typically vary by up to . Knoxville and Syracuse are separated by a distance of 656 mi.

  • What are the cheapest airlines flying from Knoxville to Syracuse round-trip?

    According to our current data, Delta ($216), American Airlines ($246), and United Airlines ($253) offers the cheapest pricing from Knoxville to Syracuse. You may be able to fly from Knoxville to Syracuse for 35% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Syracuse that include hotel bookings?

    Yes. In addition to deals on Knoxville to Syracuse flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Syracuse?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Syracuse.

  • Can I find deals for business class flights from Knoxville to Syracuse?

    Yes. Cheapflights offers flight deals from Knoxville to Syracuse by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Syracuse?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Syracuse (average of $272). Flying from Knoxville to Syracuse in July is currently the most expensive (average of $387). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Syracuse?

Book flights to Syracuse if you plan to visit one of these locations
Liverpool
Cicero
East Syracuse
Waterloo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Syracuse

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to John F Kennedy Intl flights
Nashville to LaGuardia flights
Nashville to Newark flights
Knoxville to LaGuardia flights
Memphis to Newark flights
Memphis to LaGuardia flights
Chattanooga to LaGuardia flights
Memphis to John F Kennedy Intl flights
Knoxville to John F Kennedy Intl flights
Chattanooga to John F Kennedy Intl flights
Knoxville to Newark flights
Chattanooga to Newark flights
Knoxville to Albany flights
Nashville to White Plains flights
Nashville to Buffalo flights
Nashville to Stewart flights
Nashville to Rochester flights
Nashville to Albany flights
Memphis to Buffalo flights
Nashville to Syracuse flights
Blountville to John F Kennedy Intl flights
Chattanooga to Albany flights
Blountville to Newark flights
Knoxville to Stewart flights
Blountville to LaGuardia flights
Chattanooga to Syracuse flights
Chattanooga to Buffalo flights
Knoxville to Buffalo flights
Knoxville to Rochester flights
Nashville to Islip flights
Knoxville to White Plains flights
Memphis to Albany flights
Memphis to Rochester flights
Blountville to Albany flights
Blountville to Syracuse flights
Chattanooga to Rochester flights
Knoxville to Ithaca flights
Chattanooga to Elmira flights
Nashville to Ithaca flights
Knoxville to Elmira flights
Memphis to Stewart flights
Memphis to White Plains flights
Chattanooga to White Plains flights
Memphis to Syracuse flights
Chattanooga to Stewart flights
Nashville to Binghamton flights
Nashville to Rutland flights
Nashville to Elmira flights
Knoxville to Watertown flights

Top 3 airlines flying from Knoxville to Syracuse

Discover the top 3 airlines that operate flights from Knoxville to Syracuse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$322FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$246Average$343FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$253Average$469FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.