$274+ Cheap flights from Roanoke to St. Louis (ROA - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Roanoke to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Roanoke to St. Louis
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Cheapest flights from Roanoke to St. LouisExplore the most affordable flight options available from Roanoke to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Roanoke to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:11 pm -
1 stop6h 19m
Sat 10/36:53 am -
1 stop3h 50m
Deal found 9/5![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:29 pm -
1 stop7h 15m
Sat 10/105:00 am -
1 stop4h 29m
Deal found 9/8![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
1 stop4h 49m
Sun 12/207:15 pm -
1 stop3h 58m
Deal found 9/8![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:32 pm -
1 stop6h 10m
Tue 9/294:59 pm -
1 stop6h 00m
Deal found 9/9![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1611:17 am -
1 stop6h 26m
Mon 1/186:59 pm -
1 stop4h 24m
Deal found 9/8![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
1 stop6h 29m
Fri 12/187:03 am -
1 stop6h 55m
Deal found 9/8![Delta logo]()
$359
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:20 am -
1 stop4h 09m
Sat 9/196:53 am -
1 stop7h 08m
Deal found 9/6![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop4h 00m
Sun 10/44:59 pm -
1 stop6h 00m
Deal found 9/5![Delta logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:49 pm -
1 stop5h 08m
Sun 10/115:00 am -
1 stop4h 29m
Deal found 9/8![American Airlines logo]()
$405
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:06 am -
1 stop3h 57m
Sun 9/275:15 am -
1 stop6h 08m
Deal found 9/5![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:47 pm -
1 stop7h 40m
Sun 9/276:30 am -
1 stop6h 21m
Deal found 9/5![American Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:20 am -
1 stop4h 32m
Sun 9/135:15 am -
1 stop4h 22m
Deal found 9/6![American Airlines logo]()
$424
Best flights from Roanoke to St. LouisDiscover carefully curated flight deals from Roanoke to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Roanoke to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:14 pm -
1 stop4h 16m
Sun 12/66:47 am -
1 stop4h 56m
Deal found 9/5![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
1 stop4h 49m
Mon 12/217:01 am -
1 stop5h 51m
Deal found 9/8![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:00 am -
1 stop6h 29m
Wed 12/235:13 pm -
1 stop6h 00m
Deal found 9/8![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:32 pm -
1 stop6h 10m
Tue 9/294:59 pm -
1 stop6h 00m
Deal found 9/9![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1611:17 am -
1 stop6h 26m
Mon 1/186:59 pm -
1 stop4h 24m
Deal found 9/8![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:20 pm -
2 stops8h 07m
Sat 10/310:21 am -
1 stop5h 20m
Deal found 9/7![American Airlines logo]()
$498
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:48 pm -
2 stops7h 31m
Tue 10/136:27 am -
1 stop4h 42m
Deal found 9/8![American Airlines logo]()
$498
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:17 am -
1 stop6h 07m
Sun 12/62:17 pm -
2 stops9h 10m
Deal found 9/5![Delta logo]()
$567
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/287:20 am -
2 stops11h 25m
Mon 10/56:54 pm -
1 stop4h 05m
Deal found 9/7![Delta logo]()
$567
Last-minute flights from Roanoke to St. LouisDiscover last-minute flight deals from Roanoke to St. Louis. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to St. Louis. Data last updated September 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:20 am -
1 stop4h 09m
Sat 9/196:53 am -
1 stop7h 08m
Deal found 9/6![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:47 pm -
1 stop7h 40m
Sun 9/276:30 am -
1 stop6h 21m
Deal found 9/7![American Airlines logo]()
$453
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:32 pm -
1 stop6h 10m
Tue 9/294:59 pm -
1 stop6h 00m
Deal found 9/9![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:47 pm -
1 stop7h 40m
Sun 9/276:30 am -
1 stop6h 21m
Deal found 9/5![American Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:11 pm -
1 stop6h 19m
Sat 10/36:53 am -
1 stop3h 50m
Deal found 9/5![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:29 pm -
1 stop7h 15m
Sat 10/105:00 am -
1 stop4h 29m
Deal found 9/8![American Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2610:06 am -
1 stop3h 57m
Sun 9/275:15 am -
1 stop6h 08m
Deal found 9/5![American Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop4h 00m
Sun 10/44:59 pm -
1 stop6h 00m
Deal found 9/5![Delta logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:49 pm -
1 stop5h 08m
Fri 10/95:00 am -
1 stop6h 33m
Deal found 9/8![American Airlines logo]()
$547
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:49 pm -
1 stop5h 08m
Sun 10/115:00 am -
1 stop4h 29m
Deal found 9/8![American Airlines logo]()
$405
One-way flights from Roanoke to St. LouisSearch for one-way flight options from Roanoke to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Roanoke to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:13 pm -
1 stop6h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![American Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1410:12 am -
2 stops50h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2011:13 am -
2 stops10h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Delta logo]()
$348
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 am -
1 stop4h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Delta logo]()
$463
Find flight deals from Roanoke to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (American Airlines) |
One-way from | $274 (American Airlines) |
Popular in | August |
Cheapest in | February |
Average price | $322 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Roanoke to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Tue 10/20
5:13 pm-11:04 pm
1 stop6h 51m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$274
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Fri 12/4
4:14 pm-7:30 pm
1 stop4h 16m
Lambert-St Louis
Sun 12/6
6:47 am-12:43 pm
1 stop4h 56m
$319
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Sat 12/12
6:00 am-9:49 am
1 stop4h 49m
Lambert-St Louis
Mon 12/21
7:01 am-1:52 pm
1 stop5h 51m
$339
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Mon 12/14
6:00 am-11:29 am
1 stop6h 29m
Lambert-St Louis
Wed 12/23
5:13 pm-12:13 am
1 stop6h 00m
$339
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Tue 10/20
11:13 am-8:51 pm
2 stops10h 38m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$348
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Fri 9/25
6:32 pm-11:42 pm
1 stop6h 10m
Lambert-St Louis
Tue 9/29
4:59 pm-11:59 pm
1 stop6h 00m
$349
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Wed 12/16
11:17 am-4:43 pm
1 stop6h 26m
Lambert-St Louis
Mon 1/18
6:59 pm-12:23 am
1 stop4h 24m
$354
Quickest round-trip
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Mon 9/14
6:00 am-9:00 am
1 stop4h 00m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$463
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Sat 9/26
5:20 pm-12:27 am
2 stops8h 07m
Lambert-St Louis
Sat 10/3
10:21 am-4:41 pm
1 stop5h 20m
$498
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Tue 10/6
5:48 pm-12:19 am
2 stops7h 31m
Lambert-St Louis
Tue 10/13
6:27 am-12:09 pm
1 stop4h 42m
$498
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Roanoke to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Roanoke to St. Louis in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Roanoke-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Roanoke-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Roanoke-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Roanoke-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Roanoke-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Roanoke to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Roanoke with our price prediction graph.
ROA-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to St. Louis
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 10, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Roanoke to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Crew
8.5
Overall
7.8
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Roanoke to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Edwardsville
Glencoe
Chesterfield
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Roanoke and St. Louis flights
Browse other Roanoke and St. Louis flight options. Last updated on September 10, 2026.
Other flights from Roanoke
Browse through other flights departing from Roanoke. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Top 3 airlines flying from Roanoke to St. Louis
Discover the top 3 airlines that operate flights from Roanoke to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$421 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$371 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$254 | Average$373 | FlexibilityNo cancel fee | On-timeN/A |