$218+ Cheap flights from Roanoke (ROA) to Missouri
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
Nov 12 — Nov 191
Round-trip
1 adult, Economy
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Find cheap flights from Roanoke to Missouri with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Roanoke to MissouriExplore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
Explore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:18 pm -
1 stop4h 24m
Sat 11/76:15 am -
2 stops8h 19m
Deal found 10/13![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop4h 28m
Mon 11/96:54 pm -
1 stop4h 25m
Deal found 10/13![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop7h 43m
Sat 11/148:22 am -
1 stop6h 12m
Deal found 10/10![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:10 pm -
1 stop6h 48m
Sun 11/16:34 am -
1 stop5h 09m
Deal found 10/8![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:13 pm -
1 stop5h 40m
Sat 10/3110:40 am -
1 stop4h 38m
Deal found 10/12![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:26 am -
2 stops8h 08m
Mon 11/97:36 am -
1 stop4h 50m
Deal found 10/11![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:10 pm -
1 stop6h 49m
Sun 10/257:16 am -
1 stop6h 25m
Deal found 10/9![American Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:55 pm -
2 stops9h 03m
Sat 10/318:00 am -
2 stops10h 07m
Deal found 10/12![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:10 pm -
1 stop6h 49m
Mon 10/2612:49 pm -
1 stop3h 56m
Deal found 10/11![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:03 pm -
1 stop7h 30m
Mon 11/306:02 am -
1 stop6h 51m
Deal found 10/12![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:03 pm -
1 stop7h 15m
Fri 11/66:02 am -
1 stop6h 56m
Deal found 10/9![American Airlines logo]()
$443
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:38 pm -
1 stop6h 16m
Tue 10/207:20 pm -
1 stop4h 07m
Deal found 10/10![Delta logo]()
$444
Best flights from Roanoke to MissouriDiscover carefully curated flight deals from Roanoke to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
Discover carefully curated flight deals from Roanoke to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/412:20 pm -
2 stops10h 55m
Sat 11/76:15 am -
2 stops11h 38m
Deal found 10/13![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop4h 28m
Mon 11/96:54 pm -
1 stop4h 25m
Deal found 10/11![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:26 am -
2 stops8h 08m
Mon 11/97:36 am -
1 stop4h 50m
Deal found 10/11![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:07 am -
1 stop5h 27m
Sun 11/16:03 am -
1 stop6h 50m
Deal found 10/11![American Airlines logo]()
$384
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:55 pm -
2 stops9h 03m
Sat 10/318:00 am -
2 stops10h 07m
Deal found 10/12![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/65:15 am -
1 stop7h 00m
Sat 1/97:31 am -
1 stop4h 59m
Deal found 10/8![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/1510:00 am -
2 stops8h 20m
Sun 1/176:26 pm -
1 stop5h 19m
Deal found 10/11![United Airlines logo]()
$444
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:30 am -
2 stops12h 39m
Sun 12/65:31 pm -
1 stop5h 55m
Deal found 10/10![Delta logo]()
$577
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:49 am -
1 stop6h 20m
Wed 10/286:01 am -
1 stop6h 25m
Deal found 10/9![United Airlines logo]()
$464
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:12 am -
2 stops10h 39m
Wed 10/287:20 pm -
1 stop4h 07m
Deal found 10/9![Delta logo]()
$599
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:38 pm -
1 stop6h 16m
Sat 10/3110:35 am -
2 stops10h 22m
Deal found 10/11![Delta logo]()
$599
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/105:38 pm -
1 stop6h 16m
Wed 4/149:23 am -
1 stop6h 33m
Deal found 10/8![United Airlines logo]()
$553
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:30 am -
1 stop28h 14m
Fri 11/136:01 am -
2 stops7h 14m
Deal found 10/9![United Airlines logo]()
$571
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:00 am -
2 stops9h 28m
Sat 11/146:40 am -
2 stops9h 57m
Deal found 10/10![Delta logo]()
$716
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:00 am -
1 stop5h 15m
Thu 10/291:00 pm -
1 stop5h 07m
Deal found 10/10![United Airlines logo]()
$737
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:00 am -
2 stops9h 18m
Thu 10/298:00 am -
2 stops10h 07m
Deal found 10/10![United Airlines logo]()
$888
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
2 stops9h 18m
Sun 11/88:00 am -
1 stop24h 26m
Deal found 10/12![United Airlines logo]()
$958
Last-minute flights from Roanoke to MissouriDiscover last-minute flight deals from Roanoke to Missouri. Data last updated October 13, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to Missouri. Data last updated October 13, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop4h 09m
Tue 10/205:35 pm -
1 stop5h 52m
Deal found 10/10![Delta logo]()
$444
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:10 pm -
1 stop6h 49m
Mon 10/2612:49 pm -
1 stop3h 56m
Deal found 10/11![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:10 pm -
1 stop6h 49m
Sun 10/257:16 am -
1 stop6h 25m
Deal found 10/9![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:10 pm -
1 stop6h 48m
Sun 11/16:34 am -
1 stop5h 09m
Deal found 10/8![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:13 pm -
1 stop5h 40m
Sat 10/3110:40 am -
1 stop4h 38m
Deal found 10/12![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:55 pm -
2 stops9h 03m
Sat 10/318:00 am -
2 stops10h 07m
Deal found 10/12![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:03 pm -
1 stop7h 15m
Fri 11/66:02 am -
1 stop6h 56m
Deal found 10/9![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:18 pm -
1 stop4h 24m
Sat 11/76:15 am -
2 stops8h 19m
Deal found 10/13![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop4h 28m
Mon 11/96:54 pm -
1 stop4h 25m
Deal found 10/13![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop7h 43m
Sat 11/148:22 am -
1 stop6h 12m
Deal found 10/10![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:26 am -
2 stops8h 08m
Mon 11/97:36 am -
1 stop4h 50m
Deal found 10/11![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:03 pm -
1 stop7h 30m
Mon 11/306:02 am -
1 stop6h 51m
Deal found 10/12![American Airlines logo]()
$439
One-way flights from Roanoke to MissouriSearch for one-way flight options from Roanoke to Missouri. Find affordable one-way fares based on user searches. Data last updated October 13, 2026.
Search for one-way flight options from Roanoke to Missouri. Find affordable one-way fares based on user searches. Data last updated October 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/123:12 pm -
2 stops18h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![Multiple Airlines logo]()
$218
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:53 am -
1 stop5h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![American Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:08 pm -
1 stop4h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
2 stops8h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:53 am -
1 stop4h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![United Airlines logo]()
$410
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:10 am -
2 stops12h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![Delta logo]()
$415
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:51 pm -
1 stop4h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![United Airlines logo]()
$420
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:51 pm -
1 stop17h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![United Airlines logo]()
$555
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:00 am -
2 stops18h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![United Airlines logo]()
$622
Find flight deals from Roanoke to Missouri
Keep the following information in mind while searching for Roanoke to Missouri flight deals. Data was last updated October 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $334 (American Airlines) |
One-way from | $218 (Kiwi.com) |
Popular in | August |
Cheapest in | February |
Average price | $338 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
Use the filters below to find and compare flights from Roanoke to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RoanokeKansas City
ROA Roanoke - MCI Kansas City
ROAMCI
Roanoke
Thu 11/12
3:12 pm-8:46 am
2 stops18h 34m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$218
RoanokeKansas City
ROA Roanoke - MCI Kansas City
ROAMCI
Roanoke
Thu 11/12
8:53 am-12:56 pm
1 stop5h 03m
Kansas City
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$284
RoanokeColumbia
ROA Roanoke - COU Columbia Regional
ROACOU
Roanoke
Wed 11/4
12:20 pm-10:15 pm
2 stops10h 55m
Columbia Regional
Sat 11/7
6:15 am-6:53 pm
2 stops11h 38m
$339
RoanokeKansas City
ROA Roanoke - MCI Kansas City
ROAMCI
Roanoke
Sat 11/7
6:00 am-9:28 am
1 stop4h 28m
Kansas City
Mon 11/9
6:54 pm-12:19 am
1 stop4h 25m
$339
RoanokeKansas City
ROA Roanoke - MCI Kansas City
ROAMCI
Roanoke
Sat 11/7
10:26 am-5:34 pm
2 stops8h 08m
Kansas City
Mon 11/9
7:36 am-1:26 pm
1 stop4h 50m
$359
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Tue 10/27
6:00 am-1:53 pm
2 stops8h 53m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$374
RoanokeKansas City
ROA Roanoke - MCI Kansas City
ROAMCI
Roanoke
Sat 10/24
5:07 am-9:34 am
1 stop5h 27m
Kansas City
Sun 11/1
6:03 am-1:53 pm
1 stop6h 50m
$384
RoanokeColumbia
ROA Roanoke - COU Columbia Regional
ROACOU
Roanoke
Tue 10/27
2:55 pm-10:58 pm
2 stops9h 03m
Columbia Regional
Sat 10/31
8:00 am-7:07 pm
2 stops10h 07m
$389
Quickest round-trip
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Tue 10/20
10:53 am-2:17 pm
1 stop4h 24m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$410
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Tue 10/20
5:13 pm-11:04 pm
1 stop6h 51m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$410
Showing 1-10 of 25 resultsSorted by cheapest first
Best time to book a flight from Roanoke to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Roanoke with our price prediction graph.
ROA-COU
ROA-MCI
ROA-STL
ROA-JLN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to Missouri
ROA-USMO
ROA-COU
ROA-MCI
ROA-STL
ROA-JLN
What is the cheapest month to book a flight from Roanoke to Missouri?
Currently, February is the cheapest month in which you can book a flight from Roanoke to Missouri (average of $325). Flying from Roanoke to Missouri in October is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Roanoke to Missouri?
Airfare is typical for this route at the moment.
Roanoke to Missouri flights typically cost between $323 and $546 in January.The cheapest round-trip price found within the last 5 days was $339 on American Airlines (Jan 23-Jan 24).
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated October 13, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Roanoke to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Food
7.2
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Food
7.2
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Food
7.2
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Food
7.2
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Roanoke to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Roanoke to Missouri
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Complete your trip
Complete your trip to Missouri by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Roanoke to Missouri by cabin class
Find flights from Roanoke to Missouri, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Roanoke and Missouri flights
Browse other Roanoke and Missouri flight options. Last updated on October 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Roanoke to Missouri flights
Consider these flights traveling from Roanoke to Missouri.
Top 3 airlines flying from Roanoke to Missouri
Discover the top 3 airlines that operate flights from Roanoke to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$390 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$254 | Average$371 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$269 | Average$532 | FlexibilityNo cancel fee | On-time69% |