$198+ Cheap flights from Roanoke (ROA) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
Sep 24 — Oct 11
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Roanoke to MissouriExplore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 25, 2026.
Explore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 25, 2026.
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop4h 28m
Sun 11/12:39 pm -
1 stop6h 18m
Deal found 8/23![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop4h 00m
Mon 10/56:54 pm -
1 stop4h 05m
Deal found 8/24![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:51 pm -
1 stop4h 56m
Sat 9/266:00 am -
2 stops10h 04m
Deal found 8/22![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:47 pm -
1 stop7h 36m
Mon 9/142:54 pm -
1 stop5h 05m
Deal found 8/23![American Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop4h 34m
Sat 9/1210:40 am -
1 stop4h 12m
Deal found 8/22![Delta logo]()
$334
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:59 am -
1 stop4h 46m
Mon 9/76:00 am -
1 stop7h 30m
Deal found 8/21![American Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:15 am -
2 stops9h 03m
Mon 9/75:39 pm -
1 stop5h 04m
Deal found 8/21![United Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:00 am -
1 stop4h 34m
Sat 9/123:54 pm -
1 stop4h 57m
Deal found 8/24![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:00 am -
2 stops18h 16m
Sun 9/137:05 am -
1 stop6h 46m
Deal found 8/22![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am -
1 stop4h 20m
Tue 9/83:40 pm -
1 stop5h 11m
Deal found 8/24![Delta logo]()
$368
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:00 am -
1 stop4h 34m
Sat 9/121:40 pm -
1 stop19h 51m
Deal found 8/22![Delta logo]()
$372
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:59 pm -
1 stop4h 59m
Sat 9/1210:40 am -
1 stop4h 12m
Deal found 8/24![Delta logo]()
$379
Best flights from Roanoke to MissouriDiscover carefully curated flight deals from Roanoke to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 25, 2026.
Discover carefully curated flight deals from Roanoke to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 25, 2026.
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop4h 28m
Sun 11/12:39 pm -
1 stop6h 18m
Deal found 8/22![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:51 pm -
1 stop4h 56m
Sat 9/266:00 am -
2 stops10h 04m
Deal found 8/22![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:47 pm -
1 stop7h 36m
Mon 9/142:54 pm -
1 stop5h 05m
Deal found 8/22![American Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:38 pm -
1 stop6h 18m
Wed 10/214:23 pm -
1 stop7h 04m
Deal found 8/23![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop4h 22m
Fri 10/95:31 pm -
1 stop5h 56m
Deal found 8/25![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
1 stop4h 00m
Thu 10/87:00 am -
1 stop6h 52m
Deal found 8/21![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/97:00 am -
1 stop4h 28m
Wed 1/1311:30 am -
1 stop4h 26m
Deal found 8/24![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop4h 00m
Fri 10/97:20 pm -
1 stop4h 07m
Deal found 8/21![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:51 pm -
1 stop4h 47m
Wed 10/217:30 am -
2 stops10h 37m
Deal found 8/23![United Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop4h 00m
Thu 10/87:20 pm -
1 stop4h 07m
Deal found 8/21![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:41 am -
1 stop5h 24m
Sun 10/116:22 pm -
1 stop4h 22m
Deal found 8/22![American Airlines logo]()
$491
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:59 pm -
1 stop5h 55m
Mon 10/125:35 pm -
1 stop5h 52m
Deal found 8/25![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:12 pm -
2 stops7h 30m
Thu 10/223:15 pm -
1 stop5h 38m
Deal found 8/24![American Airlines logo]()
$493
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:40 pm -
1 stop6h 02m
Sun 10/47:05 am -
1 stop6h 46m
Deal found 8/21![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:32 pm -
1 stop5h 26m
Sat 10/33:54 pm -
1 stop4h 57m
Deal found 8/21![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:05 pm -
2 stops15h 43m
Mon 10/125:36 pm -
1 stop4h 23m
Deal found 8/25![United Airlines logo]()
$534
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop5h 51m
Thu 11/125:30 pm -
1 stop5h 49m
Deal found 8/25![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:46 pm -
1 stop4h 12m
Mon 9/144:59 pm -
1 stop6h 00m
Deal found 8/22![Delta logo]()
$334
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:00 am -
1 stop4h 09m
Thu 11/52:25 pm -
1 stop6h 32m
Deal found 8/25![Delta logo]()
$334
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:35 am -
2 stops10h 59m
Thu 10/226:00 am -
2 stops16h 44m
Deal found 8/24![United Airlines logo]()
$657
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:00 am -
1 stop4h 34m
Mon 9/144:59 pm -
1 stop6h 00m
Deal found 8/25![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:51 pm -
1 stop6h 27m
Sun 10/119:00 am -
2 stops13h 44m
Deal found 8/25![United Airlines logo]()
$727
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:59 pm -
1 stop4h 59m
Sun 9/63:44 pm -
1 stop4h 59m
Deal found 8/24![Delta logo]()
$454
Last-minute flights from Roanoke to MissouriDiscover last-minute flight deals from Roanoke to Missouri. Data last updated August 25, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to Missouri. Data last updated August 25, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:59 pm -
1 stop4h 59m
Sat 9/1210:40 am -
1 stop4h 12m
Deal found 8/24![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:59 am -
1 stop4h 46m
Mon 9/76:00 am -
1 stop7h 30m
Deal found 8/21![American Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:15 am -
2 stops9h 03m
Mon 9/75:39 pm -
1 stop5h 04m
Deal found 8/21![United Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am -
1 stop4h 20m
Tue 9/83:40 pm -
1 stop5h 11m
Deal found 8/24![Delta logo]()
$368
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am -
1 stop4h 34m
Sat 9/1210:40 am -
1 stop4h 12m
Deal found 8/22![Delta logo]()
$334
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:00 am -
1 stop4h 34m
Sat 9/123:54 pm -
1 stop4h 57m
Deal found 8/24![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:29 pm -
1 stop7h 43m
Mon 9/142:54 pm -
1 stop6h 54m
Deal found 8/24![American Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:00 am -
2 stops18h 16m
Sun 9/137:05 am -
1 stop6h 46m
Deal found 8/22![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:00 am -
1 stop4h 34m
Sat 9/121:40 pm -
1 stop19h 51m
Deal found 8/22![Delta logo]()
$372
This United Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:51 pm -
1 stop4h 56m
Sat 9/265:46 pm -
1 stop4h 58m
Deal found 8/22![United Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am -
1 stop4h 34m
Mon 10/510:05 am -
1 stop3h 46m
Deal found 8/21![Delta logo]()
$319
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am -
1 stop4h 00m
Wed 10/77:20 pm -
1 stop4h 07m
Deal found 8/21![Delta logo]()
$388
One-way flights from Roanoke to MissouriSearch for one-way flight options from Roanoke to Missouri. Find affordable one-way fares based on user searches. Data last updated August 25, 2026.
Search for one-way flight options from Roanoke to Missouri. Find affordable one-way fares based on user searches. Data last updated August 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:25 pm -
3 stops22h 06m
Deal found 8/21![Multiple Airlines logo]()
$198
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop14h 58m
Deal found 8/21![Delta logo]()
$267
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:40 pm -
1 stop6h 11m
Deal found 8/21![Delta logo]()
$274
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am -
1 stop5h 55m
Deal found 8/21![Delta logo]()
$274
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:40 am -
2 stops10h 31m
Deal found 8/21![United Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:42 pm -
3 stops30h 35m
Deal found 8/21![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:59 pm -
3 stops42h 36m
Deal found 8/21![Multiple Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/38:50 am -
2 stops12h 45m
Deal found 8/21![Delta logo]()
$336
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:20 am -
2 stops17h 22m
Deal found 8/21![Delta logo]()
$342
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:20 am -
2 stops11h 25m
Deal found 8/21![Delta logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:37 pm -
3 stops50h 00m
Deal found 8/22![Multiple Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:20 am -
2 stops17h 22m
Deal found 8/21![Delta logo]()
$368
Find flight deals from Roanoke to Missouri
Keep the following information in mind while searching for Roanoke to Missouri flight deals. Data was last updated August 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (Delta) |
One-way from | $198 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $327 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 25, 2026.
Use the filters below to find and compare flights from Roanoke to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RoanokeKansas City
ROA Roanoke - MCI Kansas City
ROAMCI
Roanoke
Sat 10/24
6:00 am-9:28 am
1 stop4h 28m
Kansas City
Sun 11/1
2:39 pm-9:57 pm
1 stop6h 18m
$319
RoanokeKansas City
ROA Roanoke - MCI Kansas City
ROAMCI
Roanoke
Fri 10/16
6:38 pm-11:56 pm
1 stop6h 18m
Kansas City
Wed 10/21
4:23 pm-12:27 am
1 stop7h 04m
$319
RoanokeKansas City
ROA Roanoke - MCI Kansas City
ROAMCI
Roanoke
Fri 10/2
6:00 am-9:22 am
1 stop4h 22m
Kansas City
Fri 10/9
5:31 pm-12:27 am
1 stop5h 56m
$319
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Tue 9/29
6:00 am-9:00 am
1 stop4h 00m
Lambert-St Louis
Thu 10/8
7:00 am-2:52 pm
1 stop6h 52m
$319
Quickest round-trip
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Wed 9/30
6:00 am-9:00 am
1 stop4h 00m
Lambert-St Louis
Fri 10/9
7:20 pm-12:27 am
1 stop4h 07m
$319
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Thu 10/1
6:00 am-9:00 am
1 stop4h 00m
Lambert-St Louis
Thu 10/8
7:20 pm-12:27 am
1 stop4h 07m
$319
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Fri 10/9
6:59 pm-11:54 pm
1 stop5h 55m
Lambert-St Louis
Mon 10/12
5:35 pm-12:27 am
1 stop5h 52m
$319
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Wed 9/30
6:40 pm-11:42 pm
1 stop6h 02m
Lambert-St Louis
Sun 10/4
7:05 am-2:51 pm
1 stop6h 46m
$319
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Mon 9/28
3:32 pm-7:58 pm
1 stop5h 26m
Lambert-St Louis
Sat 10/3
3:54 pm-9:51 pm
1 stop4h 57m
$319
RoanokeSt. Louis
ROA Roanoke - STL Lambert-St Louis
ROASTL
Roanoke
Thu 11/5
6:00 am-10:51 am
1 stop5h 51m
Lambert-St Louis
Thu 11/12
5:30 pm-12:19 am
1 stop5h 49m
$319
Showing 1-10 of 39 resultsSorted by cheapest first
Best time to book a flight from Roanoke to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Roanoke with our price prediction graph.
ROA-MCI
ROA-STL
ROA-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to Missouri
ROA-USMO
ROA-MCI
ROA-STL
ROA-SGF
What is the cheapest month to book a flight from Roanoke to Missouri?
Currently, September is the cheapest month in which you can book a flight from Roanoke to Missouri (average of $318). Flying from Roanoke to Missouri in March is currently the most expensive (average of $579). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Roanoke to Missouri?
Airfare is below average for this route at the moment.
Roanoke to Missouri flights typically cost between $365 and $495 in October.The cheapest round-trip price found within the last 5 days was $319 on Delta (Oct 1-Oct 5).
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated August 25, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Roanoke to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Roanoke to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Roanoke and Missouri flights
Browse other Roanoke and Missouri flight options. Last updated on August 25, 2026.
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Roanoke to Missouri flights
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Top 3 airlines flying from Roanoke to Missouri
Discover the top 3 airlines that operate flights from Roanoke to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$176 | Average$437 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$412 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$254 | Average$371 | FlexibilityNo cancel fee | On-timeN/A |