$194+ Cheap flights from Roanoke (ROA) to Missouri
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — STL
May 1 — May 81
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Roanoke to MissouriExplore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.
Explore the most affordable flight options available from Roanoke to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:15 am
ROA
- STL
1 stop4h 34m
United Airlines
Mon 8/245:00 am
STL
- ROA
1 stop7h 35m
United Airlines
Deal found 3/29![United Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
ROA
- MCI
1 stop4h 29m
Delta
Sat 6/65:13 pm
MCI
- ROA
1 stop4h 45m
Delta
Deal found 3/30![Delta logo]()
$327
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:15 am
ROA
- MCI
1 stop5h 53m
Delta
Mon 8/105:26 pm
MCI
- ROA
1 stop5h 24m
Delta
Deal found 3/31![Delta logo]()
$328
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:50 pm
ROA
- MCI
1 stop5h 00m
Delta
Tue 4/216:47 pm
MCI
- ROA
1 stop4h 38m
Delta
Deal found 3/27![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:57 pm
ROA
- STL
1 stop4h 59m
Delta
Mon 7/67:12 pm
STL
- ROA
1 stop4h 17m
Delta
Deal found 3/31![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:40 am
ROA
- MCI
1 stop4h 49m
United Airlines
Tue 8/113:14 pm
MCI
- ROA
2 stops7h 29m
United Airlines
Deal found 3/28![United Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:37 am
ROA
- MCI
1 stop6h 48m
United Airlines
Mon 4/207:00 pm
MCI
- ROA
1 stop4h 37m
United Airlines
Deal found 4/1![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:51 pm
ROA
- STL
1 stop5h 07m
Delta
Mon 4/1311:42 am
STL
- ROA
1 stop6h 25m
Delta
Deal found 3/27![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:04 am
ROA
- STL
1 stop7h 25m
American Airlines
Sun 12/66:53 pm
STL
- ROA
1 stop4h 10m
American Airlines
Deal found 4/1![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
ROA
- MCI
1 stop6h 11m
Delta
Sat 7/183:42 pm
MCI
- ROA
1 stop5h 01m
Delta
Deal found 3/30![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
ROA
- STL
1 stop4h 44m
Delta
Sat 8/13:39 pm
STL
- ROA
1 stop5h 04m
Delta
Deal found 3/31![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:05 am
ROA
- SGF
2 stops12h 01m
Delta
Mon 5/186:52 pm
SGF
- ROA
1 stop4h 42m
Delta
Deal found 3/29![Delta logo]()
$358
Best flights from Roanoke to MissouriDiscover carefully curated flight deals from Roanoke to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 1, 2026.
Discover carefully curated flight deals from Roanoke to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 1, 2026.
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
ROA
- MCI
1 stop4h 29m
Delta
Sat 6/65:13 pm
MCI
- ROA
1 stop4h 45m
Delta
Deal found 3/27![Delta logo]()
$327
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:40 am
ROA
- MCI
1 stop4h 49m
United Airlines
Tue 8/117:45 am
MCI
- ROA
1 stop4h 50m
United Airlines
Deal found 3/28![United Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:00 am
ROA
- SGF
1 stop6h 14m
American Airlines
Sun 4/1910:21 am
SGF
- ROA
1 stop12h 49m
American Airlines
Deal found 3/28![American Airlines logo]()
$587
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:15 am
ROA
- MCI
1 stop5h 53m
Delta
Mon 8/105:26 pm
MCI
- ROA
1 stop5h 24m
Delta
Deal found 3/27![Delta logo]()
$328
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:40 am
ROA
- STL
1 stop6h 31m
United Airlines
Sat 5/305:41 pm
STL
- ROA
1 stop5h 43m
United Airlines
Deal found 4/1![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:50 pm
ROA
- MCI
1 stop5h 02m
Delta
Tue 9/295:26 pm
MCI
- ROA
1 stop5h 24m
Delta
Deal found 3/29![Delta logo]()
$328
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:47 pm
ROA
- STL
1 stop4h 49m
Delta
Sun 4/266:50 pm
STL
- ROA
1 stop4h 35m
Delta
Deal found 3/28![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:57 pm
ROA
- STL
1 stop4h 59m
Delta
Mon 7/67:12 pm
STL
- ROA
1 stop4h 17m
Delta
Deal found 3/27![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:05 am
ROA
- STL
1 stop5h 32m
Delta
Sun 5/107:01 pm
STL
- ROA
1 stop4h 33m
Delta
Deal found 3/29![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:50 pm
ROA
- MCI
1 stop5h 00m
Delta
Mon 4/205:12 pm
MCI
- ROA
1 stop6h 13m
Delta
Deal found 3/30![Delta logo]()
$334
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:50 pm
ROA
- MCI
1 stop5h 00m
Delta
Tue 4/216:47 pm
MCI
- ROA
1 stop4h 38m
Delta
Deal found 3/28![Delta logo]()
$334
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:51 pm
ROA
- STL
1 stop5h 07m
Delta
Mon 4/1311:42 am
STL
- ROA
1 stop6h 25m
Delta
Deal found 3/27![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
ROA
- SGF
2 stops9h 13m
United Airlines
Mon 5/186:22 pm
SGF
- ROA
2 stops14h 35m
United Airlines
Deal found 3/29![United Airlines logo]()
$656
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
ROA
- STL
1 stop4h 44m
Delta
Sat 8/13:39 pm
STL
- ROA
1 stop5h 04m
Delta
Deal found 3/31![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:05 am
ROA
- SGF
2 stops12h 01m
Delta
Mon 5/186:52 pm
SGF
- ROA
1 stop4h 42m
Delta
Deal found 3/29![Delta logo]()
$358
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:45 pm
ROA
- SGF
1 stop7h 51m
United Airlines
Sun 4/196:50 pm
SGF
- ROA
2 stops18h 23m
United Airlines
Deal found 3/29![United Airlines logo]()
$741
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:57 pm
ROA
- STL
1 stop4h 56m
Delta
Thu 7/235:19 pm
STL
- ROA
1 stop6h 06m
Delta
Deal found 3/27![Delta logo]()
$378
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:50 pm
ROA
- STL
2 stops13h 56m
Delta
Mon 5/115:15 pm
STL
- ROA
1 stop6h 19m
Delta
Deal found 3/29![Delta logo]()
$395
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:05 am
ROA
- STL
1 stop6h 18m
Delta
Mon 5/1110:19 am
STL
- ROA
2 stops13h 15m
Delta
Deal found 3/29![Delta logo]()
$415
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:00 am
ROA
- STL
1 stop4h 49m
Delta
Mon 5/1110:19 am
STL
- ROA
2 stops11h 41m
Delta
Deal found 3/29![Delta logo]()
$415
Last-minute flights from Roanoke to MissouriDiscover last-minute flight deals from Roanoke to Missouri. Data last updated April 1, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to Missouri. Data last updated April 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:00 pm
ROA
- MCI
1 stop4h 59m
American Airlines
Wed 4/86:00 am
MCI
- ROA
1 stop5h 33m
American Airlines
Deal found 3/28![American Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/411:08 am
ROA
- MCI
1 stop5h 58m
Delta
Wed 4/156:47 pm
MCI
- ROA
1 stop4h 38m
Delta
Deal found 3/27![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:00 am
ROA
- MCI
2 stops9h 08m
American Airlines
Wed 4/156:06 pm
MCI
- ROA
1 stop5h 04m
American Airlines
Deal found 3/27![American Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/107:51 pm
ROA
- MCI
1 stop5h 21m
Delta
Sun 4/126:41 pm
MCI
- ROA
1 stop4h 23m
Delta
Deal found 3/29![Delta logo]()
$399
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:51 pm
ROA
- STL
1 stop5h 07m
Delta
Mon 4/1311:42 am
STL
- ROA
1 stop6h 25m
Delta
Deal found 3/27![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:37 am
ROA
- MCI
1 stop6h 48m
United Airlines
Mon 4/207:00 pm
MCI
- ROA
1 stop4h 37m
United Airlines
Deal found 4/1![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:50 pm
ROA
- MCI
1 stop5h 00m
Delta
Tue 4/216:47 pm
MCI
- ROA
1 stop4h 38m
Delta
Deal found 3/27![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:18 pm
ROA
- MCI
1 stop7h 00m
American Airlines
Tue 4/217:05 am
MCI
- ROA
2 stops9h 28m
American Airlines
Deal found 3/31![American Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:47 pm
ROA
- STL
1 stop4h 49m
Delta
Sun 4/266:50 pm
STL
- ROA
1 stop4h 35m
Delta
Deal found 3/31![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:05 am
ROA
- SGF
2 stops12h 01m
Delta
Mon 5/186:52 pm
SGF
- ROA
1 stop4h 42m
Delta
Deal found 3/29![Delta logo]()
$358
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:40 am
ROA
- MCI
1 stop4h 49m
United Airlines
Mon 5/256:36 pm
MCI
- ROA
1 stop4h 48m
United Airlines
Deal found 3/29![United Airlines logo]()
$403
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
ROA
- MCI
1 stop4h 29m
Delta
Sat 6/65:13 pm
MCI
- ROA
1 stop4h 45m
Delta
Deal found 3/30![Delta logo]()
$327
One-way flights from Roanoke to MissouriSearch for one-way flight options from Roanoke to Missouri. Find affordable one-way fares based on user searches. Data last updated April 1, 2026.
Search for one-way flight options from Roanoke to Missouri. Find affordable one-way fares based on user searches. Data last updated April 1, 2026.
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:28 am
ROA
- STL
1 stop15h 51m
American Airlines
Deal found 3/31![American Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:08 pm
ROA
- MCI
2 stops26h 21m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$245
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
ROA
- STL
1 stop15h 30m
American Airlines
Deal found 3/30![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:59 pm
ROA
- STL
2 stops13h 26m
United Airlines
Deal found 3/31![United Airlines logo]()
$275
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:00 am
ROA
- MCI
1 stop4h 31m
Delta
Deal found 4/1![Delta logo]()
$279
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:00 am
ROA
- MCI
1 stop7h 26m
American Airlines
Deal found 3/30![American Airlines logo]()
$310
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:15 am
ROA
- STL
2 stops16h 01m
United Airlines
Deal found 3/30![United Airlines logo]()
$385
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:10 pm
ROA
- STL
3 stops48h 29m
Multiple Airlines
Deal found 3/30![Multiple Airlines logo]()
$1,115
Find flight deals from Roanoke to Missouri
Keep the following information in mind while searching for Roanoke to Missouri flight deals. Data was last updated April 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $324 (United Airlines) |
One-way from | $194 (American Airlines) |
Popular in | May |
Cheapest in | February |
Average price | $372 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Roanoke to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Sat 5/30
6:00 am-9:29 am
1 stop4h 29m
Kansas City
Sat 6/6
5:13 pm-10:58 pm
1 stop4h 45m
$327
RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Thu 8/6
6:40 am-10:29 am
1 stop4h 49m
Kansas City
Tue 8/11
7:45 am-1:35 pm
1 stop4h 50m
$328
RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Sat 8/1
7:15 am-12:08 pm
1 stop5h 53m
Kansas City
Mon 8/10
5:26 pm-11:50 pm
1 stop5h 24m
$328
RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Fri 9/25
7:50 pm-11:52 pm
1 stop5h 02m
Kansas City
Tue 9/29
5:26 pm-11:50 pm
1 stop5h 24m
$328
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Wed 5/27
6:40 am-12:11 pm
1 stop6h 31m
Lambert-St Louis
Sat 5/30
5:41 pm-12:24 am
1 stop5h 43m
$329
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Fri 4/24
7:47 pm-11:36 pm
1 stop4h 49m
Lambert-St Louis
Sun 4/26
6:50 pm-12:25 am
1 stop4h 35m
$329
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Wed 7/1
7:57 pm-11:56 pm
1 stop4h 59m
Lambert-St Louis
Mon 7/6
7:12 pm-12:29 am
1 stop4h 17m
$329
RoanokeSt. Louis
ROA - STL
ROASTL
Roanoke
Sat 5/9
7:05 am-11:37 am
1 stop5h 32m
Lambert-St Louis
Sun 5/10
7:01 pm-12:34 am
1 stop4h 33m
$329
RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Fri 4/17
7:50 pm-11:50 pm
1 stop5h 00m
Kansas City
Mon 4/20
5:12 pm-12:25 am
1 stop6h 13m
$334
RoanokeKansas City
ROA - MCI
ROAMCI
Roanoke
Fri 4/17
7:50 pm-11:50 pm
1 stop5h 00m
Kansas City
Tue 4/21
6:47 pm-12:25 am
1 stop4h 38m
$334
Showing 1-10 of 28 resultsSorted by cheapest first
Best time to book a flight from Roanoke to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Roanoke with our price prediction graph.
ROA-STL
ROA-MCI
ROA-SGF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to Missouri
ROA-USMO
ROA-STL
ROA-MCI
ROA-SGF
What is the cheapest month to book a flight from Roanoke to Missouri?
Currently, November is the cheapest month in which you can book a flight from Roanoke to Missouri (average of $183). Flying from Roanoke to Missouri in March is currently the most expensive (average of $256). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Roanoke to Missouri?
Reviews of airlines servicing Missouri
Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 1, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Roanoke to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Roanoke to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Roanoke to Missouri
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Complete your trip
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Roanoke and Missouri flights
Browse other Roanoke and Missouri flight options. Last updated on April 1, 2026.
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Roanoke to Missouri flights
Consider these flights traveling from Roanoke to Missouri.
Top 3 airlines flying from Roanoke to Missouri
Discover the top 3 airlines that operate flights from Roanoke to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$176 | Average$484 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$420 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$350 | FlexibilityNo cancel fee | On-timeN/A |