$313+ Cheap flights from Roanoke (ROA) to Mississippi
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — JAN
Oct 10 — Oct 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Roanoke to Mississippi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Roanoke to Mississippi
Cheapest
Best
Last-minute
One-way
Cheapest flights from Roanoke to MississippiExplore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:18 pm -
1 stop4h 42m
Sun 11/226:30 pm -
1 stop4h 08m
Deal found 9/7![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/72:55 pm -
2 stops9h 49m
Sun 11/87:00 am -
1 stop5h 26m
Deal found 9/9![United Airlines logo]()
$341
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:51 pm -
1 stop6h 53m
Mon 11/22:40 pm -
2 stops8h 04m
Deal found 9/6![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:10 pm -
1 stop4h 32m
Sun 11/15:12 am -
1 stop6h 31m
Deal found 9/7![American Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:38 pm -
1 stop5h 31m
Sun 10/117:29 pm -
1 stop3h 58m
Deal found 9/9![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:13 am -
1 stop4h 17m
Mon 11/24:49 pm -
1 stop4h 08m
Deal found 9/7![Delta logo]()
$373
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop3h 33m
Sun 10/117:29 pm -
1 stop3h 58m
Deal found 9/8![Delta logo]()
$384
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:00 pm -
2 stops9h 26m
Wed 9/232:37 pm -
1 stop5h 17m
Deal found 9/9![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/277:55 pm -
1 stop4h 42m
Mon 1/48:00 am -
1 stop5h 40m
Deal found 9/8![Delta logo]()
$393
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:51 pm -
1 stop6h 53m
Sat 10/312:40 pm -
1 stop5h 21m
Deal found 9/8![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:00 am -
1 stop3h 29m
Thu 9/247:04 pm -
1 stop3h 55m
Deal found 9/9![Delta logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:49 am -
2 stops10h 20m
Sat 10/310:50 am -
2 stops11h 09m
Deal found 9/8![United Airlines logo]()
$409
Best flights from Roanoke to MississippiDiscover carefully curated flight deals from Roanoke to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Roanoke to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:51 pm -
1 stop6h 53m
Mon 11/22:40 pm -
2 stops8h 04m
Deal found 9/7![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:10 pm -
1 stop4h 32m
Sun 11/15:12 am -
1 stop6h 31m
Deal found 9/7![American Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:38 pm -
1 stop5h 46m
Mon 11/23:35 pm -
1 stop5h 22m
Deal found 9/6![Delta logo]()
$373
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/277:55 pm -
1 stop4h 42m
Mon 1/48:00 am -
1 stop5h 40m
Deal found 9/8![Delta logo]()
$393
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:55 pm -
2 stops9h 49m
Sat 10/319:51 am -
2 stops8h 16m
Deal found 9/8![United Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop3h 33m
Sun 10/117:29 pm -
1 stop3h 58m
Deal found 9/9![Delta logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:49 am -
2 stops10h 20m
Sat 10/310:50 am -
2 stops11h 09m
Deal found 9/8![United Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:59 pm -
1 stop5h 25m
Sun 10/117:35 pm -
1 stop3h 52m
Deal found 9/7![Delta logo]()
$415
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/192:55 pm -
2 stops8h 14m
Sun 11/226:30 pm -
1 stop4h 08m
Deal found 9/7![American Airlines logo]()
$504
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop3h 33m
Sun 10/185:35 am -
1 stop3h 57m
Deal found 9/8![Delta logo]()
$428
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:35 am -
2 stops12h 03m
Mon 10/510:50 am -
2 stops11h 54m
Deal found 9/5![United Airlines logo]()
$474
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:00 am -
1 stop6h 17m
Fri 11/136:10 pm -
1 stop5h 09m
Deal found 9/5![Delta logo]()
$432
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:31 am -
2 stops7h 40m
Sun 10/116:45 pm -
1 stop3h 59m
Deal found 9/9![American Airlines logo]()
$692
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am -
1 stop3h 30m
Sun 10/46:10 pm -
1 stop4h 49m
Deal found 9/5![Delta logo]()
$477
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/173:00 pm -
2 stops26h 36m
Tue 1/121:57 pm -
2 stops22h 33m
Deal found 9/8![United Airlines logo]()
$868
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:32 pm -
1 stop4h 12m
Sun 10/185:35 am -
1 stop3h 57m
Deal found 9/6![Delta logo]()
$718
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:15 am -
2 stops16h 43m
Sun 10/115:20 pm -
2 stops15h 37m
Deal found 9/9![United Airlines logo]()
$932
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:51 pm -
2 stops27h 09m
Sun 10/185:20 pm -
2 stops15h 37m
Deal found 9/9![United Airlines logo]()
$934
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:35 am -
3 stops10h 25m
Sun 10/1112:02 pm -
2 stops9h 57m
Deal found 9/9![United Airlines logo]()
$1,202
Last-minute flights from Roanoke to MississippiDiscover last-minute flight deals from Roanoke to Mississippi. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to Mississippi. Data last updated September 10, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:00 pm -
2 stops9h 26m
Wed 9/232:37 pm -
1 stop5h 17m
Deal found 9/9![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:00 am -
1 stop3h 29m
Thu 9/247:04 pm -
1 stop3h 55m
Deal found 9/9![Delta logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:49 am -
2 stops10h 20m
Sat 10/310:50 am -
2 stops11h 09m
Deal found 9/8![United Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:32 pm -
1 stop5h 48m
Mon 10/56:10 pm -
1 stop4h 49m
Deal found 9/5![Delta logo]()
$467
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:38 pm -
1 stop5h 31m
Sun 10/117:29 pm -
1 stop3h 58m
Deal found 9/9![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop3h 33m
Sun 10/117:29 pm -
1 stop3h 58m
Deal found 9/8![Delta logo]()
$384
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:59 pm -
1 stop5h 25m
Sun 10/117:35 pm -
1 stop3h 52m
Deal found 9/7![Delta logo]()
$415
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop5h 25m
Sun 10/185:35 am -
1 stop3h 57m
Deal found 9/6![Delta logo]()
$428
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:10 pm -
1 stop4h 32m
Sun 11/15:12 am -
1 stop6h 31m
Deal found 9/7![American Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:51 pm -
1 stop6h 53m
Sat 10/312:40 pm -
1 stop5h 21m
Deal found 9/8![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:51 pm -
1 stop6h 53m
Mon 11/22:40 pm -
2 stops8h 04m
Deal found 9/6![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:13 am -
1 stop4h 17m
Mon 11/24:49 pm -
1 stop4h 08m
Deal found 9/7![Delta logo]()
$373
One-way flights from Roanoke to MississippiSearch for one-way flight options from Roanoke to Mississippi. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Roanoke to Mississippi. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:10 pm -
1 stop4h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$313
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:15 am -
2 stops12h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$355
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:51 pm -
2 stops21h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![United Airlines logo]()
$489
Find flight deals from Roanoke to Mississippi
Keep the following information in mind while searching for Roanoke to Mississippi flight deals. Data was last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (American Airlines) |
One-way from | $313 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Roanoke to Mississippi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
RoanokeMemphis
ROA Roanoke - MEM Memphis
ROAMEM
Roanoke
Fri 10/9
6:10 pm-9:42 pm
1 stop4h 32m
Memphis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$313
RoanokeMemphis
ROA Roanoke - MEM Memphis
ROAMEM
Roanoke
Fri 10/30
5:51 pm-11:44 pm
1 stop6h 53m
Memphis
Mon 11/2
2:40 pm-11:44 pm
2 stops8h 04m
$344
RoanokeMemphis
ROA Roanoke - MEM Memphis
ROAMEM
Roanoke
Wed 10/28
6:10 pm-9:42 pm
1 stop4h 32m
Memphis
Sun 11/1
5:12 am-12:43 pm
1 stop6h 31m
$353
RoanokeMemphis
ROA Roanoke - MEM Memphis
ROAMEM
Roanoke
Mon 10/5
6:15 am-5:39 pm
2 stops12h 24m
Memphis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$355
RoanokeMemphis
ROA Roanoke - MEM Memphis
ROAMEM
Roanoke
Fri 10/30
6:38 pm-11:24 pm
1 stop5h 46m
Memphis
Mon 11/2
3:35 pm-9:57 pm
1 stop5h 22m
$373
RoanokeMemphis
ROA Roanoke - MEM Memphis
ROAMEM
Roanoke
Sun 12/27
7:55 pm-11:37 pm
1 stop4h 42m
Memphis
Mon 1/4
8:00 am-2:40 pm
1 stop5h 40m
$393
RoanokeJackson
ROA Roanoke - JAN Jackson-Evers Intl
ROAJAN
Roanoke
Thu 10/8
6:00 am-8:33 am
1 stop3h 33m
Jackson-Evers Intl
Sun 10/11
7:29 pm-12:27 am
1 stop3h 58m
$399
RoanokeMemphis
ROA Roanoke - MEM Memphis
ROAMEM
Roanoke
Wed 10/28
2:55 pm-11:44 pm
2 stops9h 49m
Memphis
Sat 10/31
9:51 am-7:07 pm
2 stops8h 16m
$409
RoanokeMobile
ROA Roanoke - MOB Mobile
ROAMOB
Roanoke
Tue 9/29
6:49 am-4:09 pm
2 stops10h 20m
Mobile
Sat 10/3
10:50 am-10:59 pm
2 stops11h 09m
$409
RoanokeMemphis
ROA Roanoke - MEM Memphis
ROAMEM
Roanoke
Fri 10/9
6:59 pm-11:24 pm
1 stop5h 25m
Memphis
Sun 10/11
7:35 pm-12:27 am
1 stop3h 52m
$415
Showing 1-10 of 22 resultsSorted by cheapest first
Best time to book a flight from Roanoke to Mississippi
Have a flexible travel schedule? Discover the best time to fly to Mississippi from Roanoke with our price prediction graph.
ROA-MEM
ROA-JAN
ROA-MOB
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to Mississippi
ROA-USMS
ROA-MEM
ROA-JAN
ROA-MOB
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mississippi
Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated September 10, 2026.
Read through reviews of airlines operating flights from Roanoke to Mississippi, such as Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Boarding
8.1
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Roanoke to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Roanoke to Mississippi
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Mississippi by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Roanoke to Mississippi by cabin class
Find flights from Roanoke to Mississippi, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Roanoke and Mississippi flights
Browse other Roanoke and Mississippi flight options. Last updated on September 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Roanoke to Mississippi flights
Consider these flights traveling from Roanoke to Mississippi.
Top airline flying from Roanoke to Mississippi
Discover the top airline that operate flights from Roanoke to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$290 | Average$464 | FlexibilityNo cancel fee | On-timeN/A |