$224+ Cheap flights from Roanoke (ROA) to Mississippi
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — JAN
May 21 — May 281
Round-trip
1 adult, Economy
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Find cheap flights from Roanoke to Mississippi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Roanoke to Mississippi
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Cheapest flights from Roanoke to MississippiExplore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
Explore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am
ROA
- JAN
1 stop6h 22m
Delta
Mon 11/306:59 pm
JAN
- ROA
1 stop3h 50m
Delta
Deal found 4/20![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:05 am
ROA
- MEM
1 stop6h 07m
Delta
Sat 5/165:54 pm
MEM
- ROA
1 stop4h 04m
Delta
Deal found 4/17![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
ROA
- MEM
1 stop6h 20m
Delta
Wed 5/612:17 pm
MEM
- ROA
1 stop5h 48m
Delta
Deal found 4/16![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:09 am
ROA
- MEM
1 stop5h 19m
American Airlines
Wed 5/69:03 am
MEM
- ROA
2 stops7h 30m
American Airlines
Deal found 4/16![American Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:00 am
ROA
- MEM
1 stop4h 32m
Delta
Sun 9/205:55 pm
MEM
- ROA
1 stop4h 55m
Delta
Deal found 4/17![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:00 am
ROA
- MEM
1 stop4h 35m
Delta
Sat 5/28:21 am
MEM
- ROA
1 stop5h 26m
Delta
Deal found 4/17![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:09 am
ROA
- MEM
2 stops7h 14m
American Airlines
Sat 5/212:58 pm
MEM
- ROA
1 stop5h 37m
American Airlines
Deal found 4/17![American Airlines logo]()
$384
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2810:34 am
ROA
- MEM
2 stops12h 30m
United Airlines
Mon 5/46:00 am
MEM
- ROA
2 stops12h 10m
United Airlines
Deal found 4/20![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:10 pm
ROA
- MEM
1 stop7h 27m
American Airlines
Sun 9/275:34 am
MEM
- ROA
1 stop3h 56m
American Airlines
Deal found 4/20![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:47 pm
ROA
- MEM
1 stop5h 10m
United Airlines
Mon 9/212:39 pm
MEM
- ROA
2 stops8h 04m
United Airlines
Deal found 4/17![United Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:45 am
ROA
- MEM
1 stop5h 09m
United Airlines
Tue 5/1911:10 am
MEM
- ROA
1 stop4h 49m
United Airlines
Deal found 4/20![United Airlines logo]()
$417
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:50 pm
ROA
- JAN
1 stop4h 25m
Delta
Sun 4/266:59 pm
JAN
- ROA
1 stop4h 26m
Delta
Deal found 4/17![Delta logo]()
$434
Best flights from Roanoke to MississippiDiscover carefully curated flight deals from Roanoke to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
Discover carefully curated flight deals from Roanoke to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:05 am
ROA
- MEM
1 stop6h 07m
Delta
Sat 5/165:54 pm
MEM
- ROA
1 stop4h 04m
Delta
Deal found 4/16![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:42 pm
ROA
- MEM
1 stop7h 06m
United Airlines
Sat 5/99:02 am
MEM
- ROA
1 stop6h 57m
United Airlines
Deal found 4/16![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/108:09 am
ROA
- MEM
2 stops7h 09m
American Airlines
Sat 5/166:04 am
MEM
- ROA
1 stop5h 29m
American Airlines
Deal found 4/19![American Airlines logo]()
$547
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:47 pm
ROA
- MEM
1 stop4h 39m
Delta
Sat 5/95:30 am
MEM
- ROA
1 stop4h 00m
Delta
Deal found 4/16![Delta logo]()
$334
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:00 am
ROA
- MEM
1 stop4h 32m
Delta
Sun 9/205:55 pm
MEM
- ROA
1 stop4h 55m
Delta
Deal found 4/17![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:47 pm
ROA
- MEM
1 stop5h 10m
United Airlines
Mon 9/212:39 pm
MEM
- ROA
2 stops8h 04m
United Airlines
Deal found 4/17![United Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:45 am
ROA
- MEM
1 stop5h 09m
United Airlines
Tue 5/1911:10 am
MEM
- ROA
1 stop4h 49m
United Airlines
Deal found 4/20![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:45 am
ROA
- MEM
1 stop5h 09m
United Airlines
Sat 5/1611:10 am
MEM
- ROA
2 stops11h 34m
United Airlines
Deal found 4/18![United Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:15 am
ROA
- MOB
2 stops10h 54m
United Airlines
Sat 9/59:30 am
MOB
- ROA
2 stops13h 13m
United Airlines
Deal found 4/17![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2611:10 am
ROA
- MOB
1 stop5h 54m
American Airlines
Sun 6/284:29 pm
MOB
- ROA
1 stop6h 18m
American Airlines
Deal found 4/17![American Airlines logo]()
$665
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:00 am
ROA
- MEM
1 stop6h 32m
Delta
Fri 5/297:07 pm
MEM
- ROA
1 stop4h 27m
Delta
Deal found 4/17![Delta logo]()
$557
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:48 am
ROA
- MOB
1 stop6h 29m
American Airlines
Sat 7/184:30 pm
MOB
- ROA
1 stop4h 48m
American Airlines
Deal found 4/16![American Airlines logo]()
$681
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:30 pm
ROA
- JAN
1 stop4h 48m
Delta
Sun 5/177:23 pm
JAN
- ROA
1 stop4h 11m
Delta
Deal found 4/21![Delta logo]()
$669
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:59 pm
ROA
- JAN
2 stops16h 17m
United Airlines
Sun 5/1712:00 pm
JAN
- ROA
2 stops24h 34m
United Airlines
Deal found 4/21![United Airlines logo]()
$1,011
Last-minute flights from Roanoke to MississippiDiscover last-minute flight deals from Roanoke to Mississippi. Data last updated April 21, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to Mississippi. Data last updated April 21, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:50 pm
ROA
- JAN
1 stop4h 25m
Delta
Sun 4/266:59 pm
JAN
- ROA
1 stop4h 26m
Delta
Deal found 4/17![Delta logo]()
$434
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:09 am
ROA
- JAN
2 stops11h 00m
American Airlines
Sun 4/266:39 pm
JAN
- ROA
1 stop3h 58m
American Airlines
Deal found 4/17![American Airlines logo]()
$584
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2810:34 am
ROA
- MEM
2 stops12h 30m
United Airlines
Mon 5/46:00 am
MEM
- ROA
2 stops12h 10m
United Airlines
Deal found 4/20![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:00 am
ROA
- MEM
1 stop4h 35m
Delta
Sat 5/28:21 am
MEM
- ROA
1 stop5h 26m
Delta
Deal found 4/17![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:09 am
ROA
- MEM
2 stops7h 14m
American Airlines
Sat 5/212:58 pm
MEM
- ROA
1 stop5h 37m
American Airlines
Deal found 4/17![American Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
ROA
- MEM
1 stop6h 20m
Delta
Wed 5/612:17 pm
MEM
- ROA
1 stop5h 48m
Delta
Deal found 4/16![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:09 am
ROA
- MEM
1 stop5h 19m
American Airlines
Wed 5/69:03 am
MEM
- ROA
2 stops7h 30m
American Airlines
Deal found 4/16![American Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:50 pm
ROA
- MOB
1 stop4h 08m
Delta
Fri 5/87:01 pm
MOB
- ROA
1 stop4h 33m
Delta
Deal found 4/19![Delta logo]()
$727
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:00 pm
ROA
- MOB
1 stop4h 44m
American Airlines
Fri 5/85:10 am
MOB
- ROA
2 stops11h 23m
American Airlines
Deal found 4/19![American Airlines logo]()
$732
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:05 am
ROA
- MEM
1 stop6h 07m
Delta
Sat 5/165:54 pm
MEM
- ROA
1 stop4h 04m
Delta
Deal found 4/17![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:45 am
ROA
- MEM
1 stop5h 09m
United Airlines
Tue 5/1911:10 am
MEM
- ROA
1 stop4h 49m
United Airlines
Deal found 4/20![United Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:45 pm
ROA
- MEM
1 stop5h 02m
American Airlines
Tue 5/196:47 am
MEM
- ROA
2 stops9h 46m
American Airlines
Deal found 4/20![American Airlines logo]()
$433
One-way flights from Roanoke to MississippiSearch for one-way flight options from Roanoke to Mississippi. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
Search for one-way flight options from Roanoke to Mississippi. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:38 pm
ROA
- MEM
3 stops44h 54m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$260
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:00 am
ROA
- MEM
1 stop5h 35m
Delta
Deal found 4/21![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:45 am
ROA
- MEM
1 stop5h 09m
United Airlines
Deal found 4/18![United Airlines logo]()
$364
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:09 am
ROA
- MEM
2 stops7h 14m
American Airlines
Deal found 4/18![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:50 pm
ROA
- JAN
1 stop4h 25m
Delta
Deal found 4/20![Delta logo]()
$387
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:09 am
ROA
- JAN
2 stops9h 47m
American Airlines
Deal found 4/20![American Airlines logo]()
$392
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:09 am
ROA
- MEM
2 stops7h 09m
American Airlines
Deal found 4/21![American Airlines logo]()
$405
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:59 pm
ROA
- MEM
2 stops19h 40m
United Airlines
Deal found 4/21![United Airlines logo]()
$425
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2810:34 am
ROA
- JAN
3 stops12h 25m
United Airlines
Deal found 4/20![United Airlines logo]()
$637
Find flight deals from Roanoke to Mississippi
Keep the following information in mind while searching for Roanoke to Mississippi flight deals. Data was last updated April 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $329 (Delta) |
One-way from | $260 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from Roanoke to Mississippi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Sun 5/10
7:05 am-12:12 pm
1 stop6h 07m
Memphis
Sat 5/16
5:54 pm-10:58 pm
1 stop4h 04m
$329
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Wed 5/6
5:42 pm-11:48 pm
1 stop7h 06m
Memphis
Sat 5/9
9:02 am-4:59 pm
1 stop6h 57m
$334
Quickest round-trip
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Wed 5/6
7:47 pm-11:26 pm
1 stop4h 39m
Memphis
Sat 5/9
5:30 am-10:30 am
1 stop4h 00m
$334
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Fri 9/18
6:00 am-9:32 am
1 stop4h 32m
Memphis
Sun 9/20
5:55 pm-11:50 pm
1 stop4h 55m
$354
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Fri 9/18
5:47 pm-9:57 pm
1 stop5h 10m
Memphis
Mon 9/21
2:39 pm-11:43 pm
2 stops8h 04m
$412
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Sat 5/16
6:45 am-10:54 am
1 stop5h 09m
Memphis
Tue 5/19
11:10 am-4:59 pm
1 stop4h 49m
$417
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Sun 5/10
6:45 am-10:54 am
1 stop5h 09m
Memphis
Sat 5/16
11:10 am-11:44 pm
2 stops11h 34m
$459
RoanokeMobile
ROA - MOB
ROAMOB
Roanoke
Wed 9/2
6:15 am-4:09 pm
2 stops10h 54m
Mobile
Sat 9/5
9:30 am-11:43 pm
2 stops13h 13m
$459
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Sun 5/10
8:09 am-2:18 pm
2 stops7h 09m
Memphis
Sat 5/16
6:04 am-12:33 pm
1 stop5h 29m
$547
RoanokeMemphis
ROA - MEM
ROAMEM
Roanoke
Sun 5/24
6:00 am-11:32 am
1 stop6h 32m
Memphis
Fri 5/29
7:07 pm-12:34 am
1 stop4h 27m
$557
Showing 1-10 of 26 resultsSorted by cheapest first
Best time to book a flight from Roanoke to Mississippi
Have a flexible travel schedule? Discover the best time to fly to Mississippi from Roanoke with our price prediction graph.
ROA-MEM
ROA-JAN
ROA-MOB
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to Mississippi
ROA-USMS
ROA-MEM
ROA-JAN
ROA-MOB
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mississippi
Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated April 21, 2026.
Read through reviews of airlines operating flights from Roanoke to Mississippi, such as Delta and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Comfort
7.9
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Overall
7.9
Comfort
7.9
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Roanoke to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Roanoke to Mississippi
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Complete your trip
Complete your trip to Mississippi by adding a car rental and/or hotel reservation to your travel itinerary.
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Roanoke and Mississippi flights
Browse other Roanoke and Mississippi flight options. Last updated on April 21, 2026.
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Roanoke to Mississippi flights
Consider these flights traveling from Roanoke to Mississippi.
Top 2 airlines flying from Roanoke to Mississippi
Discover the top 2 airlines that operate flights from Roanoke to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$353 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$438 | FlexibilityNo cancel fee | On-timeN/A |