$408+ Cheap flights from Roanoke (ROA) to Mississippi
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — JAN
Dec 3 — Dec 101
Round-trip
1 adult, Economy
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Find cheap flights from Roanoke to Mississippi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Roanoke to MississippiExplore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
Explore the most affordable flight options available from Roanoke to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:55 pm -
1 stop5h 10m
Sun 12/205:59 pm -
1 stop5h 13m
Deal found 11/1![Delta logo]()
$408
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:14 pm -
1 stop4h 05m
Sat 11/147:42 am -
1 stop6h 52m
Deal found 10/29![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
1 stop4h 17m
Sat 11/144:00 pm -
1 stop4h 55m
Deal found 11/2![Delta logo]()
$444
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:03 pm -
1 stop6h 58m
Mon 12/75:42 pm -
1 stop4h 11m
Deal found 10/31![American Airlines logo]()
$529
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:40 am -
2 stops9h 54m
Wed 11/181:54 pm -
2 stops8h 50m
Deal found 10/30![United Airlines logo]()
$552
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
2 stops11h 08m
Sat 11/147:00 am -
2 stops13h 01m
Deal found 11/2![United Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
2 stops7h 13m
Sat 11/146:45 am -
1 stop4h 10m
Deal found 11/2![American Airlines logo]()
$589
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:18 pm -
1 stop5h 42m
Tue 11/245:00 am -
1 stop4h 29m
Deal found 10/29![American Airlines logo]()
$653
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:00 am -
1 stop4h 19m
Sun 11/296:04 pm -
1 stop5h 15m
Deal found 10/30![Delta logo]()
$752
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:16 pm -
2 stops9h 00m
Sun 12/206:24 pm -
1 stop4h 32m
Deal found 11/1![American Airlines logo]()
$758
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:54 pm -
1 stop4h 23m
Tue 11/176:00 am -
1 stop3h 37m
Deal found 10/29![Delta logo]()
$774
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:26 am -
2 stops10h 08m
Fri 11/204:55 pm -
2 stops15h 31m
Deal found 11/1![United Airlines logo]()
$872
Best flights from Roanoke to MississippiDiscover carefully curated flight deals from Roanoke to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
Discover carefully curated flight deals from Roanoke to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:03 pm -
1 stop6h 58m
Mon 12/75:42 pm -
1 stop4h 11m
Deal found 10/31![American Airlines logo]()
$529
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:40 am -
2 stops9h 54m
Wed 11/181:54 pm -
2 stops8h 50m
Deal found 10/30![United Airlines logo]()
$552
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:54 pm -
1 stop4h 23m
Tue 11/176:00 am -
1 stop3h 37m
Deal found 10/29![Delta logo]()
$774
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:18 pm -
1 stop5h 42m
Tue 11/245:00 am -
2 stops7h 53m
Deal found 10/29![American Airlines logo]()
$751
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:16 pm -
2 stops9h 00m
Sun 12/206:24 pm -
1 stop4h 32m
Deal found 11/1![American Airlines logo]()
$758
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:26 am -
2 stops10h 08m
Fri 11/204:55 pm -
2 stops15h 31m
Deal found 11/1![United Airlines logo]()
$872
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/188:05 pm -
2 stops26h 54m
Sun 12/205:20 pm -
2 stops19h 10m
Deal found 11/1![United Airlines logo]()
$982
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/107:00 am -
2 stops15h 18m
Wed 4/141:57 pm -
2 stops18h 26m
Deal found 11/1![United Airlines logo]()
$985
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:55 pm -
2 stops10h 06m
Sun 11/295:49 pm -
1 stop4h 49m
Deal found 10/30![American Airlines logo]()
$1,126
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:00 am -
2 stops20h 39m
Mon 12/75:05 pm -
2 stops25h 07m
Deal found 10/31![United Airlines logo]()
$1,091
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:00 am -
2 stops10h 29m
Tue 11/173:59 pm -
1 stop6h 59m
Deal found 10/29![American Airlines logo]()
$1,142
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/202:55 pm -
2 stops30h 31m
Tue 11/241:57 pm -
2 stops28h 10m
Deal found 10/29![United Airlines logo]()
$1,123
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2510:26 am -
3 stops10h 08m
Sun 11/294:55 pm -
2 stops9h 08m
Deal found 10/30![United Airlines logo]()
$1,840
Last-minute flights from Roanoke to MississippiDiscover last-minute flight deals from Roanoke to Mississippi. Data last updated November 3, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to Mississippi. Data last updated November 3, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:14 pm -
1 stop4h 05m
Sat 11/147:42 am -
1 stop6h 52m
Deal found 10/29![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
1 stop4h 17m
Sat 11/144:00 pm -
1 stop4h 55m
Deal found 11/2![Delta logo]()
$444
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
2 stops11h 08m
Sat 11/147:00 am -
2 stops13h 01m
Deal found 11/2![United Airlines logo]()
$555
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
2 stops7h 13m
Sat 11/146:45 am -
1 stop4h 10m
Deal found 11/2![American Airlines logo]()
$589
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:40 am -
2 stops9h 54m
Wed 11/181:54 pm -
2 stops8h 50m
Deal found 10/30![United Airlines logo]()
$552
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:54 pm -
1 stop4h 23m
Tue 11/176:00 am -
1 stop3h 37m
Deal found 10/29![Delta logo]()
$774
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:26 am -
2 stops10h 08m
Fri 11/204:55 pm -
2 stops15h 31m
Deal found 11/1![United Airlines logo]()
$872
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:18 pm -
1 stop5h 42m
Tue 11/245:00 am -
1 stop4h 29m
Deal found 10/29![American Airlines logo]()
$653
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:00 am -
1 stop4h 19m
Sun 11/296:04 pm -
1 stop5h 15m
Deal found 10/30![Delta logo]()
$752
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:03 pm -
1 stop6h 58m
Sun 11/295:49 pm -
1 stop4h 49m
Deal found 10/30![American Airlines logo]()
$1,025
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:03 pm -
1 stop6h 58m
Mon 12/75:42 pm -
1 stop4h 11m
Deal found 10/31![American Airlines logo]()
$529
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:00 am -
2 stops20h 39m
Mon 12/75:05 pm -
2 stops25h 07m
Deal found 10/31![United Airlines logo]()
$1,091
Find flight deals from Roanoke to Mississippi
Keep the following information in mind while searching for Roanoke to Mississippi flight deals. Data was last updated November 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $369 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
Use the filters below to find and compare flights from Roanoke to Mississippi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RoanokeGulfport
ROA Roanoke - GPT Gulfport Biloxi Regional
ROAGPT
Roanoke
Sat 11/28
6:03 pm-12:01 am
1 stop6h 58m
Gulfport Biloxi Regional
Mon 12/7
5:42 pm-10:53 pm
1 stop4h 11m
$529
RoanokeGulfport
ROA Roanoke - GPT Gulfport Biloxi Regional
ROAGPT
Roanoke
Sat 11/14
10:40 am-7:34 pm
2 stops9h 54m
Gulfport Biloxi Regional
Wed 11/18
1:54 pm-11:44 pm
2 stops8h 50m
$552
RoanokeJackson
ROA Roanoke - JAN Jackson-Evers Intl
ROAJAN
Roanoke
Fri 11/20
1:18 pm-6:00 pm
1 stop5h 42m
Jackson-Evers Intl
Tue 11/24
5:00 am-1:53 pm
2 stops7h 53m
$751
RoanokeJackson
ROA Roanoke - JAN Jackson-Evers Intl
ROAJAN
Roanoke
Fri 12/18
2:16 pm-10:16 pm
2 stops9h 00m
Jackson-Evers Intl
Sun 12/20
6:24 pm-11:56 pm
1 stop4h 32m
$758
Quickest round-trip
RoanokeColumbus
ROA Roanoke - GTR Columbus Golden Triangle Reg.
ROAGTR
Roanoke
Mon 11/16
6:54 pm-10:17 pm
1 stop4h 23m
Columbus Golden Triangle Reg.
Tue 11/17
6:00 am-10:37 am
1 stop3h 37m
$774
RoanokeGulfport
ROA Roanoke - GPT Gulfport Biloxi Regional
ROAGPT
Roanoke
Mon 11/16
10:26 am-7:34 pm
2 stops10h 08m
Gulfport Biloxi Regional
Fri 11/20
4:55 pm-9:26 am
2 stops15h 31m
$872
RoanokeJackson
ROA Roanoke - JAN Jackson-Evers Intl
ROAJAN
Roanoke
Fri 12/18
8:05 pm-9:59 pm
2 stops26h 54m
Jackson-Evers Intl
Sun 12/20
5:20 pm-1:30 pm
2 stops19h 10m
$982
RoanokeJackson
ROA Roanoke - JAN Jackson-Evers Intl
ROAJAN
Roanoke
Sat 4/10
7:00 am-9:18 pm
2 stops15h 18m
Jackson-Evers Intl
Wed 4/14
1:57 pm-9:23 am
2 stops18h 26m
$985
RoanokeGulfport
ROA Roanoke - GPT Gulfport Biloxi Regional
ROAGPT
Roanoke
Sat 11/28
6:00 am-1:39 am
2 stops20h 39m
Gulfport Biloxi Regional
Mon 12/7
5:05 pm-7:12 pm
2 stops25h 07m
$1,091
RoanokeJackson
ROA Roanoke - JAN Jackson-Evers Intl
ROAJAN
Roanoke
Fri 11/20
2:55 pm-8:26 pm
2 stops30h 31m
Jackson-Evers Intl
Tue 11/24
1:57 pm-7:07 pm
2 stops28h 10m
$1,123
Showing 1-10 of 13 resultsSorted by cheapest first
Best time to book a flight from Roanoke to Mississippi
Have a flexible travel schedule? Discover the best time to fly to Mississippi from Roanoke with our price prediction graph.
ROA-JAN
ROA-GPT
ROA-GTR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to Mississippi
ROA-USMS
ROA-JAN
ROA-GPT
ROA-GTR
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mississippi
Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated November 3, 2026.
Read through reviews of airlines operating flights from Roanoke to Mississippi, such as Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Overall
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Roanoke to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Roanoke to Mississippi
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Complete your trip
Complete your trip to Mississippi by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Roanoke to Mississippi, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Roanoke and Mississippi flights
Browse other Roanoke and Mississippi flight options. Last updated on November 3, 2026.
Popular flight searches
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Roanoke to Mississippi flights
Consider these flights traveling from Roanoke to Mississippi.
Top airline flying from Roanoke to Mississippi
Discover the top airline that operate flights from Roanoke to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$290 | Average$464 | FlexibilityNo cancel fee | On-timeN/A |