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St. Louis

$312+ Cheap flights from Panama to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Dec 12 — Dec 191
Fri 12/12
Fri 12/19
1 adult, Economy
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Find flight deals from Panama to St. Louis

Cheapest flights from Panama to St. Louis
Explore the most affordable flight options available from Panama to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/168:55 amPTY - STL
2 stops14h 50mUnited Airlines
Tue 2/106:30 amSTL - PTY
2 stops12h 32mUnited Airlines
Deal found 11/12$537
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:41 pmPTY - STL
1 stop30h 14mUnited Airlines
Sat 1/104:49 pmSTL - PTY
2 stops23h 18mUnited Airlines
Deal found 11/12$558
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:55 pmPTY - STL
2 stops16h 40mAmerican Airlines
Thu 1/15:05 amSTL - PTY
1 stop9h 49mAmerican Airlines
Deal found 11/10$572
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/292:53 pmPTY - STL
1 stop8h 42mAmerican Airlines
Sat 1/1010:00 amSTL - PTY
1 stop28h 38mAmerican Airlines
Deal found 11/10$600
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/64:43 pmPTY - STL
1 stop8h 16mAmerican Airlines
Thu 12/117:35 pmSTL - PTY
2 stops19h 07mAmerican Airlines
Deal found 11/10$615
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/174:41 pmPTY - STL
2 stops22h 43mUnited Airlines
Mon 11/245:24 pmSTL - PTY
2 stops20h 21mUnited Airlines
Deal found 11/10$629
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/152:55 amPTY - STL
2 stops35h 55mMultiple Airlines
Tue 2/107:00 amSTL - PTY
1 stop8h 39mMultiple Airlines
Deal found 11/12$879
This Mytrip deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/192:55 amPTY - STL
3 stops33h 01mMultiple Airlines
Thu 1/111:51 amSTL - PTY
3 stops30h 04mMultiple Airlines
Deal found 11/10$1,009

Cheap flight deals from Panama to St. Louis

Keep the following information in mind while searching for Panama to St. Louis flight deals. Data was last updated November 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$537
(United Airlines)

One-way from

$312
(United Airlines)

Popular in

July

Cheapest in

June

Average price

$601
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
Search Deals
From Panama to Lambert-St Louis
Search Deals
One-way flight from Panama to Lambert-St Louis
Search Deals
High demand for flights, 1% potential price rise
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from Panama to St. Louis that are best for you.

Fly from

Panama

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 12/17

10:00 am-10:45 pm

2 stops13h 45m

Lambert-St Louis

Wed 2/11

6:00 am-2:45 pm

1 stop7h 45m

$537

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 12/16

4:41 pm-12:15 pm

2 stops20h 34m

Lambert-St Louis

Tue 2/10

6:00 am-5:07 pm

1 stop10h 07m

$537

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 5/1

2:20 pm-11:38 pm

1 stop9h 18m

Lambert-St Louis

Tue 5/5

6:00 am-12:55 pm

1 stop6h 55m

$546

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 1/12

4:50 pm-11:03 am

2 stops19h 13m

Lambert-St Louis

Mon 1/19

3:54 pm-1:27 pm

2 stops20h 33m

$551

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 5/1

10:55 pm-12:20 pm

2 stops13h 25m

Lambert-St Louis

Tue 5/5

6:45 am-6:37 pm

2 stops11h 52m

$551

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 12/16

4:41 pm-2:25 pm

2 stops22h 44m

$312

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 1/22

2:27 pm-11:59 pm

1 stop10h 32m

$317

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 1/23

4:50 pm-9:08 am

1 stop17h 18m

$317

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 2/10

10:00 am-11:02 am

2 stops26h 02m

$318

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Best time to book a flight from Panama to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to St. Louis

What is the cheapest time of day to fly from PA to STL?

Find hourly flight availability from Panama to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2025.

When flying from Panama to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 16% versus a flight in the morning.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated November 12, 2025.
Read reviews from past customers who have flown United Airlines from Panama to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,015 reviews

Entertainment

7.1

Food

6.6

Overall

7.4

Comfort

7.3

Crew

8.1

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
9,015 reviews
United Airlines
7.4
Good
9,015 reviews

Entertainment

7.1

Food

6.6

Overall

7.4

Comfort

7.3

Crew

8.1

Boarding

7.7

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Panama to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from Panama?

    If you book a flight to St. Louis from Panama, you will be flying to Lambert-St Louis, which is the city’s only airport. Lambert-St Louis (STL) is located 12.7 mi from the center of St. Louis.

  • How long is the flight from Panama to St. Louis?

    Airlines like United Airlines fly from Panama to St. Louis in about 13h 45m. The time it takes to get you to your destination can typically vary by up to . The distance from Panama to St. Louis is about 2159 mi.

  • Can I find deals for flights from Panama to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to St. Louis.

  • Can I find deals for business class flights from Panama to St. Louis?

    Yes. Cheapflights offers flight deals from Panama to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Panama to St. Louis

Discover the top airline that operate flights from Panama to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$567FlexibilityNo cancel feeOn-time69%

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