St. Louis

$333+ Cheap flights from Panama to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Aug 5 — Aug 121
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Cheap flight deals from Panama to St. Louis

Keep the following information in mind while searching for Panama to St. Louis flight deals. Data was last updated July 31, 2025.

Round-trip from

$504
(Trip.com)

One-way from

$333
(Delta)

Popular in

July

Cheapest in

June

Average price

$662
From Panama to Lambert-St Louis
One-way flight from Panama to Lambert-St Louis
High demand for flights, 8% potential price rise
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Average for round-trip flights in July 2025

Find flight deals from Panama to St. Louis

Cheapest flights from Panama to St. Louis
Explore the most affordable flight options available from Panama to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Trip.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/910:00 amPTY - STL
1 stop12h 16mUnited Airlines
Fri 9/126:15 amSTL - PTY
1 stop7h 59mUnited Airlines
Deal found 7/31$504
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/272:10 pmPTY - STL
1 stop7h 50mDelta
Tue 9/306:01 amSTL - PTY
1 stop6h 54mDelta
Deal found 7/30$546
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/273:30 pmPTY - STL
1 stop8h 29mAmerican Airlines
Fri 9/55:28 amSTL - PTY
1 stop9h 03mAmerican Airlines
Deal found 7/29$565
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/73:20 amPTY - STL
2 stops30h 20mMultiple Airlines
Sat 8/233:02 pmSTL - PTY
1 stop28h 31mMultiple Airlines
Deal found 7/31$702

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Panama to St. Louis that are best for you.

Fly from

Panama

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 9/9

10:00 am-10:16 pm

1 stop12h 16m

Lambert-St Louis

Fri 9/12

6:15 am-2:14 pm

1 stop7h 59m

$504

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 9/27

2:10 pm-10:00 pm

1 stop7h 50m

Lambert-St Louis

Tue 9/30

6:01 am-12:55 pm

1 stop6h 54m

$546

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 8/27

3:30 pm-11:59 pm

1 stop8h 29m

Lambert-St Louis

Fri 9/5

5:28 am-2:31 pm

1 stop9h 03m

$565

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 9/13

3:40 pm-9:40 am

2 stops18h 00m

Lambert-St Louis

Sat 9/20

1:00 pm-12:10 am

3 stops35h 10m

$912

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 9/4

3:20 am-6:23 pm

2 stops15h 03m

Lambert-St Louis

Fri 9/12

9:17 am-12:45 am

2 stops15h 28m

$2,394

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 10/25

2:21 pm-10:04 pm

1 stop7h 43m

$333

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 10/25

3:15 pm-11:52 am

2 stops20h 37m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/31

Best time to book a flight from Panama to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to St. Louis

What is the cheapest time of day to fly from PA to STL?

Find hourly flight availability from Panama to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to St. Louis as you normally would.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated July 31, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Panama to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
8.0
Very good
8.0
Very good

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
8.0
Very good

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
8.0
Very good

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
8.0
Very good

Overall

8.0

Boarding

8.2

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.

Related info for your journey

Find useful and relevant information for your journey from Panama to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to St. Louis from Panama?

    If you book a flight to St. Louis from Panama, you will be flying to Lambert-St Louis, which is the city’s only airport. Lambert-St Louis (STL) is located 12.7 mi from the center of St. Louis.

  • Can I find deals for flights from Panama to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to St. Louis.

  • Can I find deals for business class flights from Panama to St. Louis?

    Yes. Cheapflights offers flight deals from Panama to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama to St. Louis (average of $311). Flying from Panama to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
O'Fallon
Maryland Heights
Fairview Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Chesterfield
Festus
Farmington

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Top 2 airlines flying from Panama to St. Louis

Discover the top 2 airlines that operate flights from Panama to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$610FlexibilityNo cancel feeOn-time69%
DeltaCheapest$354Average$558FlexibilityNo cancel feeOn-timeN/A

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