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St. Louis

$429+ Cheap flights from Panama to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/28. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
mar. 15 — mar. 221
dom. 3/15
dom. 3/22
1 adult, Economy
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Cheap flight deals from Panama to St. Louis

Cheapest flights from Panama to St. Louis
Explore the most affordable flight options available from Panama to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on febrero 13, 2026.

This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/223:25 pm
PTY
-
STL
1 stop9h 14m
Delta
mar. 1/56:00 am
STL
-
PTY
1 stop7h 00m
Delta
Deal found 2/12$549
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/3010:55 pm
PTY
-
STL
2 stops13h 16m
United Airlines
mar. 6/28:37 am
STL
-
PTY
1 stop10h 00m
United Airlines
Deal found 2/8$573
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/2710:00 am
PTY
-
STL
1 stop12h 28m
United Airlines
vie. 5/16:00 am
STL
-
PTY
1 stop12h 37m
United Airlines
Deal found 2/10$579
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/271:49 pm
PTY
-
STL
2 stops21h 48m
American Airlines
vie. 5/13:43 pm
STL
-
PTY
2 stops21h 03m
American Airlines
Deal found 2/10$605
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/63:20 pm
PTY
-
STL
1 stop8h 39m
American Airlines
jue. 9/105:33 am
STL
-
PTY
1 stop8h 37m
American Airlines
Deal found 2/9$638

Find flight deals from Panama to St. Louis

Keep the following information in mind while searching for Panama to St. Louis flight deals. Data was last updated febrero 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$579
(United Airlines)

One-way from

$429
(Kiwi.com)

Popular in

January

Cheapest in

June

Average price

$559
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
Search Deals
From Panama to Lambert-St Louis
Search Deals
One-way flight from Panama to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 13, 2026.
Use the filters below to find and compare flights from Panama to St. Louis that are best for you.

Fly from

Panama

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

sáb. 5/30

10:55 pm-12:11 pm

2 stops13h 16m

Lambert-St Louis

mar. 6/2

6:00 am-6:37 pm

2 stops12h 37m

$573

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

lun. 4/27

10:00 am-10:28 pm

1 stop12h 28m

Lambert-St Louis

vie. 5/1

6:00 am-6:37 pm

1 stop12h 37m

$579

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

lun. 4/27

1:49 pm-11:37 am

2 stops21h 48m

Lambert-St Louis

vie. 5/1

3:43 pm-12:46 pm

2 stops21h 03m

$605

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

lun. 4/27

10:10 am-3:24 pm

3 stops29h 14m

Lambert-St Louis

vie. 5/1

1:00 pm-5:00 pm

2 stops28h 00m

$1,016

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

sáb. 3/28

10:26 am-10:31 am

1 stop24h 05m

$429

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Best time to book a flight from Panama to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to St. Louis

What is the cheapest month to book a flight from Panama to St. Louis?

Currently, July is the cheapest month in which you can book a flight from Panama to St. Louis (average of $230). Flying from Panama to St. Louis in January is currently the most expensive (average of $632). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated febrero 13, 2026.
Read reviews from past customers who have flown United Airlines from Panama to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,283 reviews

Boarding

7.7

Crew

8.1

Overall

7.4

Comfort

7.3

Entertainment

7.1

Food

6.6

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats
United Airlines
7.4
Good
9,283 reviews
United Airlines
7.4
Good
9,283 reviews

Boarding

7.7

Crew

8.1

Overall

7.4

Comfort

7.3

Entertainment

7.1

Food

6.6

Reviews

1 / 20
6.0
Good

Gerry,Jan 2026

YVR - DEN

Seats were uncomfortable. Second leg of my flight on United had much more comfortable seats

Related info for your journey

Find useful and relevant information for your journey from Panama to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from Panama?

    If you book a flight to St. Louis from Panama, you will be flying to Lambert-St Louis, which is the city’s only airport. Lambert-St Louis (STL) is located 12.7 mi from the center of St. Louis.

  • How long is the flight from Panama to St. Louis?

    Airlines like United Airlines fly from Panama to St. Louis in about 13h 16m. The time it takes to get you to your destination can typically vary by up to . The distance from Panama to St. Louis is about 2159 mi.

  • Can I find deals for flights from Panama to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to St. Louis.

  • Can I find deals for business class flights from Panama to St. Louis?

    Yes. Cheapflights offers flight deals from Panama to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to St. Louis?

    Currently, July is the cheapest month in which you can book a flight from Panama to St. Louis (average of $230). Flying from Panama to St. Louis in January is currently the most expensive (average of $632). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Panama to St. Louis

Discover the top airline that operate flights from Panama to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$684FlexibilityNo cancel feeOn-time69%

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