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St. Louis

$312+ Cheap flights from Panama to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Panama to St. Louis

Keep the following information in mind while searching for Panama to St. Louis flight deals. Data was last updated September 16, 2025.

Round-trip from

$515
(United Airlines)

One-way from

$312
(United Airlines)

Popular in

July

Cheapest in

February

Average price

$589
From Panama to Lambert-St Louis
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One-way flight from Panama to Lambert-St Louis
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Highest demand for flights based on searches. 0% potential increase in price ($2 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama to St. Louis

Cheapest flights from Panama to St. Louis
Explore the most affordable flight options available from Panama to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:55 amPTY - STL
1 stop26h 44mUnited Airlines
Tue 11/118:20 amSTL - PTY
1 stop29h 25mUnited Airlines
Deal found 9/15$537
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1410:00 amPTY - STL
1 stop12h 00mUnited Airlines
Tue 10/216:15 amSTL - PTY
1 stop12h 22mUnited Airlines
Deal found 9/15$558
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:15 pmPTY - STL
2 stops22h 29mAmerican Airlines
Tue 11/115:58 pmSTL - PTY
2 stops18h 51mAmerican Airlines
Deal found 9/15$562
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/222:43 pmPTY - STL
2 stops20h 56mAmerican Airlines
Fri 11/286:45 pmSTL - PTY
2 stops17h 53mAmerican Airlines
Deal found 9/13$572
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1710:00 amPTY - STL
1 stop8h 57mUnited Airlines
Wed 10/225:00 amSTL - PTY
2 stops13h 37mUnited Airlines
Deal found 9/15$580
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1112:03 pmPTY - STL
1 stop21h 59mMultiple Airlines
Thu 10/2310:57 amSTL - PTY
2 stops34h 13mMultiple Airlines
Deal found 9/15$585
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1110:00 amPTY - STL
1 stop11h 58mUnited Airlines
Wed 10/225:00 amSTL - PTY
2 stops13h 37mUnited Airlines
Deal found 9/15$601
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1210:00 amPTY - STL
1 stop12h 00mUnited Airlines
Sat 10/256:30 amSTL - PTY
2 stops12h 07mUnited Airlines
Deal found 9/15$622
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1512:03 pmPTY - STL
1 stop21h 59mMultiple Airlines
Sun 10/2610:22 amSTL - PTY
2 stops14h 38mMultiple Airlines
Deal found 9/15$675
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/163:30 pmPTY - STL
2 stops19h 19mUnited Airlines
Tue 10/216:30 amSTL - PTY
2 stops12h 07mUnited Airlines
Deal found 9/15$679
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1512:03 pmPTY - STL
1 stop21h 59mMultiple Airlines
Fri 10/2410:22 amSTL - PTY
2 stops14h 23mMultiple Airlines
Deal found 9/15$680

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Panama to St. Louis that are best for you.

Fly from

Panama

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 2/3

8:55 am-3:52 pm

1 stop7h 57m

Lambert-St Louis

Tue 3/3

6:45 pm-5:07 pm

2 stops21h 22m

$515

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 10/30

7:55 am-10:22 pm

1 stop14h 27m

Lambert-St Louis

Tue 11/11

6:15 am-7:38 pm

1 stop12h 23m

$537

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 10/16

2:21 pm-8:07 am

1 stop17h 46m

Lambert-St Louis

Sun 10/26

6:52 pm-12:56 pm

1 stop18h 04m

$558

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 10/14

3:30 pm-6:57 pm

1 stop27h 27m

Lambert-St Louis

Thu 10/23

8:25 am-6:37 pm

1 stop10h 12m

$558

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 10/13

10:00 am-10:00 pm

1 stop12h 00m

Lambert-St Louis

Tue 10/21

6:30 am-6:37 pm

2 stops12h 07m

$558

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 10/29

3:41 pm-10:51 am

2 stops19h 10m

Lambert-St Louis

Wed 11/5

8:20 am-2:45 pm

1 stop29h 25m

$558

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 11/22

4:41 pm-10:51 am

2 stops19h 10m

Lambert-St Louis

Fri 11/28

6:15 am-7:38 pm

1 stop12h 23m

$558

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 10/16

10:00 am-6:57 pm

1 stop8h 57m

Lambert-St Louis

Thu 10/23

8:25 am-6:37 pm

1 stop10h 12m

$558

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 10/14

10:00 am-10:00 pm

1 stop12h 00m

Lambert-St Louis

Tue 10/21

6:15 am-6:37 pm

1 stop12h 22m

$558

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 10/15

10:00 am-6:57 pm

1 stop8h 57m

Lambert-St Louis

Tue 10/21

6:30 am-6:37 pm

2 stops12h 07m

$558

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 18 results
1
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Best time to book a flight from Panama to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to St. Louis

What is the cheapest time of day to fly from PA to STL?

Find hourly flight availability from Panama to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to St. Louis as you normally would.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 16, 2025.
Read reviews from past customers who have flown Delta and United Airlines from Panama to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others
United Airlines
7.4
Good
8,924 reviews
Delta
8.0
Very good
7,957 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Morgan Rae,Aug 2025

BRU - JFK

Typically I choose delta because they do a great job but this time the flight attendant in my zone was very rude and didnt offer the same treatment as she did to others

Related info for your journey

Find useful and relevant information for your journey from Panama to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from Panama?

    If you book a flight to St. Louis from Panama, you will be flying to Lambert-St Louis, which is the city’s only airport. Lambert-St Louis (STL) is located 12.7 mi from the center of St. Louis.

  • How long is the flight from Panama to St. Louis?

    Airlines like United Airlines fly from Panama to St. Louis in about 7h 57m. The time it takes to get you to your destination can typically vary by up to . The distance from Panama to St. Louis is about 2159 mi.

  • Can I find deals for flights from Panama to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to St. Louis.

  • Can I find deals for business class flights from Panama to St. Louis?

    Yes. Cheapflights offers flight deals from Panama to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama to St. Louis (average of $311). Flying from Panama to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama to St. Louis

Discover the top 2 airlines that operate flights from Panama to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$598FlexibilityNo cancel feeOn-time69%
DeltaCheapest$354Average$558FlexibilityNo cancel feeOn-timeN/A

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