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St. Louis

$317+ Cheap flights from Panama to St. Louis (STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/23. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Jan 26 — Feb 21
Mon 1/26
Mon 2/2
1 adult, Economy
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Cheap flight deals from Panama to St. Louis

Cheapest flights from Panama to St. Louis
Explore the most affordable flight options available from Panama to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 27, 2025.

This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:41 pmPTY - STL
1 stop18h 08mUnited Airlines
Sat 1/104:49 pmSTL - PTY
2 stops23h 18mUnited Airlines
Deal found 12/26$650

Find flight deals from Panama to St. Louis

Keep the following information in mind while searching for Panama to St. Louis flight deals. Data was last updated December 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$516
(United Airlines)

One-way from

$317
(American Airlines)

Popular in

July

Cheapest in

June

Average price

$558
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
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From Panama to Lambert-St Louis
Search Deals
One-way flight from Panama to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($7 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Panama to St. Louis that are best for you.

Fly from

Panama

Fly to

St. Louis

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 4/14

7:55 am-9:08 pm

2 stops13h 13m

Lambert-St Louis

Thu 4/16

7:45 am-7:31 pm

2 stops11h 46m

$516

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 2/9

8:55 am-10:00 pm

1 stop14h 05m

Lambert-St Louis

Mon 2/16

6:55 pm-8:02 pm

2 stops24h 07m

$537

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/30

7:55 am-4:35 pm

1 stop8h 40m

Lambert-St Louis

Tue 6/2

11:00 am-6:37 pm

1 stop7h 37m

$546

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 1/22

2:27 pm-11:59 pm

1 stop10h 32m

$317

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 1/23

4:50 pm-11:59 pm

1 stop8h 09m

$317

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 1/22

4:41 pm-12:29 pm

2 stops20h 48m

$321

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/9

10:00 am-9:28 am

1 stop23h 28m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

Best time to book a flight from Panama to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to St. Louis

What is the cheapest month to book a flight from Panama to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Panama to St. Louis (average of $230). Flying from Panama to St. Louis in January is currently the most expensive (average of $589). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated December 27, 2025.
Read reviews from past customers who have flown United Airlines from Panama to St. Louis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,116 reviews

Crew

8.1

Food

6.6

Comfort

7.3

Overall

7.4

Boarding

7.7

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.
United Airlines
7.4
Good
9,116 reviews
United Airlines
7.4
Good
9,116 reviews

Crew

8.1

Food

6.6

Comfort

7.3

Overall

7.4

Boarding

7.7

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.

Related info for your journey

Find useful and relevant information for your journey from Panama to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to St. Louis from Panama?

    If you book a flight to St. Louis from Panama, you will be flying to Lambert-St Louis, which is the city’s only airport. Lambert-St Louis (STL) is located 12.7 mi from the center of St. Louis.

  • How long is the flight from Panama to St. Louis?

    Airlines like United Airlines fly from Panama to St. Louis in about 13h 13m. The time it takes to get you to your destination can typically vary by up to . The distance from Panama to St. Louis is about 2159 mi.

  • Can I find deals for flights from Panama to St. Louis that include hotel bookings?

    Yes. In addition to deals on Panama to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to St. Louis.

  • Can I find deals for business class flights from Panama to St. Louis?

    Yes. Cheapflights offers flight deals from Panama to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Panama to St. Louis (average of $230). Flying from Panama to St. Louis in January is currently the most expensive (average of $589). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Panama to St. Louis

Discover the top airline that operate flights from Panama to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$478Average$684FlexibilityNo cancel feeOn-time69%

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