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Missouri

$312+ Cheap flights from Panama to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — STL
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Cheap flight deals from Panama to Missouri

Keep the following information in mind while searching for Panama to Missouri flight deals. Data was last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$434
(United Airlines)

One-way from

$312
(United Airlines)

Popular in

July

Cheapest in

June

Average price

$601
Provider with most accurate pricing for Panama City Tocumen Intl-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Lambert-St Louis flights.
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From Panama to Missouri
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One-way flight from Panama to Missouri
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Panama to Missouri

Cheapest flights from Panama to Missouri
Explore the most affordable flight options available from Panama to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:41 pmPTY - MCI
2 stops17h 37mUnited Airlines
Wed 1/76:30 pmMCI - PTY
2 stops21h 37mUnited Airlines
Deal found 11/12$434
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:41 pmPTY - MCI
2 stops17h 37mUnited Airlines
Thu 1/17:40 amMCI - PTY
2 stops10h 58mUnited Airlines
Deal found 11/12$467
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/168:55 amPTY - STL
1 stop8h 09mUnited Airlines
Tue 2/1010:07 amSTL - PTY
1 stop8h 31mUnited Airlines
Deal found 11/12$537
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/38:55 amPTY - MCI
1 stop8h 43mUnited Airlines
Mon 12/156:15 amMCI - PTY
1 stop9h 52mUnited Airlines
Deal found 11/11$537
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:41 pmPTY - STL
1 stop30h 14mUnited Airlines
Sat 1/104:35 pmSTL - PTY
1 stop23h 32mUnited Airlines
Deal found 11/12$558
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:41 pmPTY - SGF
2 stops22h 57mUnited Airlines
Tue 1/63:14 pmSGF - PTY
2 stops22h 31mUnited Airlines
Deal found 11/10$561
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:50 pmPTY - MCI
1 stop10h 35mAmerican Airlines
Thu 12/116:39 pmMCI - PTY
2 stops20h 03mAmerican Airlines
Deal found 11/12$561
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/302:53 pmPTY - SGF
2 stops20h 04mAmerican Airlines
Sun 1/44:27 pmSGF - PTY
2 stops20h 26mAmerican Airlines
Deal found 11/10$574
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2711:35 amPTY - SGF
1 stop7h 52mUnited Airlines
Wed 1/73:00 pmSGF - PTY
1 stop22h 45mUnited Airlines
Deal found 11/10$582
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/292:53 pmPTY - STL
1 stop8h 42mAmerican Airlines
Sat 1/1010:00 amSTL - PTY
1 stop26h 27mAmerican Airlines
Deal found 11/12$600
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/274:41 pmPTY - SGF
2 stops19h 08mUnited Airlines
Thu 1/16:20 pmSGF - PTY
2 stops24h 18mUnited Airlines
Deal found 11/10$603
This United Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/274:41 pmPTY - STL
2 stops22h 43mUnited Airlines
Sun 11/306:15 amSTL - PTY
1 stop7h 30mUnited Airlines
Deal found 11/13$623

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Panama to Missouri that are best for you.

Fly from

Panama

Fly to

Missouri

Route

Depart

Return

Price

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Tue 12/23

4:41 pm-9:18 am

2 stops17h 37m

Kansas City

Wed 1/7

6:30 pm-8:02 pm

2 stops24h 32m

$434

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Sat 1/17

4:41 pm-9:31 am

1 stop17h 50m

Kansas City

Fri 1/23

6:30 pm-7:38 pm

2 stops24h 08m

$457

Panama CityKansas City

PTY - MCI

PTYMCI

Panama City Tocumen Intl

Sat 12/20

4:41 pm-9:18 am

2 stops17h 37m

Kansas City

Thu 1/1

6:15 am-5:07 pm

1 stop9h 52m

$467

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Wed 12/17

10:00 am-10:45 pm

2 stops13h 45m

Lambert-St Louis

Wed 2/11

6:00 am-2:45 pm

1 stop7h 45m

$537

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 12/16

4:41 pm-12:15 pm

2 stops20h 34m

Lambert-St Louis

Tue 2/10

6:00 am-5:07 pm

1 stop10h 07m

$537

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Thu 4/2

10:00 am-10:20 pm

1 stop12h 20m

Springfield-Branson

Mon 4/6

8:45 am-4:12 pm

1 stop7h 27m

$548

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 1/12

4:50 pm-11:03 am

2 stops19h 13m

Lambert-St Louis

Mon 1/19

3:54 pm-1:27 pm

2 stops20h 33m

$551

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 12/29

4:41 pm-4:36 pm

1 stop24h 55m

Lambert-St Louis

Sat 1/10

4:35 pm-2:45 pm

1 stop21h 10m

$558

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Mon 12/29

4:41 pm-5:38 pm

2 stops25h 57m

Springfield-Branson

Wed 1/7

3:14 pm-2:45 pm

2 stops22h 31m

$561

Panama CitySpringfield

PTY - SGF

PTYSGF

Panama City Tocumen Intl

Mon 12/29

4:41 pm-5:38 pm

2 stops25h 57m

Springfield-Branson

Mon 1/5

6:15 am-7:38 pm

1 stop12h 23m

$561

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 17 results
1
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Best time to book a flight from Panama to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Missouri

What is the cheapest month to book a flight from Panama to Missouri?

Currently, August is the cheapest month in which you can book a flight from Panama to Missouri (average of $237). Flying from Panama to Missouri in September is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to MO?

Find hourly flight availability from Panama to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

It’s optimal to fly from Panama to Missouri in the evening. By choosing this option you can save up to 23% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated November 13, 2025.
Read reviews from past customers who have flown United Airlines from Panama to Missouri. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,017 reviews

Comfort

7.3

Crew

8.1

Food

6.6

Boarding

7.7

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000
United Airlines
7.4
Good
9,017 reviews
United Airlines
7.4
Good
9,017 reviews

Comfort

7.3

Crew

8.1

Food

6.6

Boarding

7.7

Entertainment

7.1

Overall

7.4

Reviews

1 / 20
2.0
Mediocre

Sebrena,Oct 2025

IAH - RSW

The worst that I have ever experienced in my life so bad if it was free I'm not ever going to use your Airline again I dont believe ..... very disappointed 😞 😔0000000000000

Related info for your journey

Find useful and relevant information for your journey from Panama to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to Missouri?

    A quick flight from Panama to Missouri can take about 17h 37m. United Airlines provides one of the quickest options available for as low as $434. There are 2292 mi between Panama and Missouri.

  • Can I find deals for flights from Panama to Missouri that include hotel bookings?

    Yes. In addition to deals on Panama to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Missouri.

  • Can I find deals for business class flights from Panama to Missouri?

    Yes. Cheapflights offers flight deals from Panama to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Panama to Missouri (average of $237). Flying from Panama to Missouri in September is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama to Missouri

Discover the top airline that operate flights from Panama to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$252Average$598FlexibilityNo cancel feeOn-time69%

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