$71+ Cheap flights from Jacksonville to St. Louis (JAX - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
JAX — STL
Mar 25 — Apr 11
1 adult, Economy
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Find cheap flights from Jacksonville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Jacksonville to Lambert-St Louis are usually found in July or August, booked 88 days in advance, depart on a Tuesday or Friday and return on a Friday
Cheap flight deals from Jacksonville to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Jacksonville to St. LouisExplore the most affordable flight options available from Jacksonville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.
Explore the most affordable flight options available from Jacksonville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:25 pm
JAX
- STL
1 stop13h 25m
Frontier
Wed 4/298:23 pm
STL
- JAX
1 stop20h 07m
Frontier
Deal found 2/21![Frontier logo]()
$183
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:28 pm
JAX
- STL
1 stop12h 22m
Frontier
Sun 4/2611:44 am
STL
- JAX
1 stop4h 46m
Frontier
Deal found 2/21![Frontier logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:17 pm
JAX
- STL
1 stop11h 33m
Frontier
Sun 5/1711:21 am
STL
- JAX
1 stop4h 52m
Frontier
Deal found 2/21![Frontier logo]()
$263
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:35 pm
JAX
- STL
Nonstop2h 15m
Southwest
Tue 5/1210:15 am
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/21![Southwest logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/69:45 am
JAX
- STL
2 stops25h 04m
Multiple Airlines
Mon 3/92:09 pm
STL
- JAX
1 stop4h 24m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$286
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:15 am
JAX
- STL
Nonstop2h 20m
Southwest
Tue 3/317:15 pm
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/22![Southwest logo]()
$291
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:10 pm
JAX
- STL
1 stop7h 35m
Southwest
Mon 3/307:45 pm
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/22![Southwest logo]()
$295
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:00 am
JAX
- STL
1 stop5h 16m
American Airlines
Thu 4/91:29 pm
STL
- JAX
1 stop7h 44m
American Airlines
Deal found 2/23![American Airlines logo]()
$298
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/128:10 pm
JAX
- STL
1 stop4h 28m
Delta
Sun 6/215:30 pm
STL
- JAX
1 stop6h 38m
Delta
Deal found 2/22![Delta logo]()
$299
Best flights from Jacksonville to St. LouisDiscover carefully curated flight deals from Jacksonville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 23, 2026.
Discover carefully curated flight deals from Jacksonville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 23, 2026.
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/27:59 pm
JAX
- STL
1 stop4h 59m
Delta
Sun 4/56:59 pm
STL
- JAX
1 stop4h 00m
Delta
Deal found 2/19![Delta logo]()
$299
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:15 am
JAX
- STL
Nonstop2h 20m
Southwest
Sun 3/295:25 am
STL
- JAX
1 stop5h 45m
Southwest
Deal found 2/19![Southwest logo]()
$302
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:58 am
JAX
- STL
1 stop7h 00m
American Airlines
Fri 3/61:34 pm
STL
- JAX
1 stop4h 43m
American Airlines
Deal found 2/19![American Airlines logo]()
$351
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/243:35 pm
JAX
- STL
Nonstop2h 15m
Southwest
Sun 4/268:20 am
STL
- JAX
1 stop6h 30m
Southwest
Deal found 2/21![Southwest logo]()
$311
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:15 am
JAX
- STL
Nonstop2h 20m
Southwest
Sun 4/52:15 pm
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/19![Southwest logo]()
$314
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:10 am
JAX
- STL
1 stop5h 25m
Southwest
Mon 3/234:55 pm
STL
- JAX
1 stop6h 10m
Southwest
Deal found 2/19![Southwest logo]()
$318
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:05 am
JAX
- STL
2 stops7h 45m
Southwest
Sun 4/126:00 am
STL
- JAX
1 stop8h 50m
Southwest
Deal found 2/19![Southwest logo]()
$328
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:50 am
JAX
- STL
2 stops7h 40m
Southwest
Tue 3/316:10 am
STL
- JAX
2 stops8h 50m
Southwest
Deal found 2/22![Southwest logo]()
$334
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/125:50 am
JAX
- STL
2 stops7h 40m
Southwest
Sat 3/217:55 pm
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/21![Southwest logo]()
$348
Last-minute flights from Jacksonville to St. LouisDiscover last-minute flight deals from Jacksonville to St. Louis. Data last updated February 23, 2026 and is based on user searches.
Discover last-minute flight deals from Jacksonville to St. Louis. Data last updated February 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/69:45 am
JAX
- STL
2 stops25h 04m
Multiple Airlines
Mon 3/92:09 pm
STL
- JAX
1 stop4h 24m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:18 pm
JAX
- STL
2 stops28h 01m
Frontier
Sat 4/188:23 pm
STL
- JAX
1 stop20h 07m
Frontier
Deal found 2/19![Frontier logo]()
$267
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:10 am
JAX
- STL
1 stop5h 25m
Southwest
Mon 3/237:45 pm
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/19![Southwest logo]()
$308
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:15 am
JAX
- STL
Nonstop2h 20m
Southwest
Tue 3/317:15 pm
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/22![Southwest logo]()
$291
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:10 pm
JAX
- STL
1 stop7h 35m
Southwest
Mon 3/307:45 pm
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/22![Southwest logo]()
$295
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:59 pm
JAX
- STL
1 stop4h 59m
Delta
Mon 3/3010:12 am
STL
- JAX
1 stop5h 16m
Delta
Deal found 2/22![Delta logo]()
$299
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:15 am
JAX
- STL
Nonstop2h 20m
Southwest
Sun 3/295:25 am
STL
- JAX
1 stop5h 45m
Southwest
Deal found 2/19![Southwest logo]()
$302
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:15 am
JAX
- STL
Nonstop2h 20m
Southwest
Mon 3/307:45 pm
STL
- JAX
Nonstop2h 00m
Southwest
Deal found 2/22![Southwest logo]()
$314
One-way flights from Jacksonville to St. LouisSearch for one-way flight options from Jacksonville to St. Louis. Find affordable one-way fares based on user searches. Data last updated February 23, 2026.
Search for one-way flight options from Jacksonville to St. Louis. Find affordable one-way fares based on user searches. Data last updated February 23, 2026.
This Trip.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:18 pm
JAX
- STL
1 stop15h 14m
Frontier
Deal found 2/19![Frontier logo]()
$71
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/235:58 pm
JAX
- STL
1 stop17h 34m
Frontier
Deal found 2/19![Frontier logo]()
$77
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:18 pm
JAX
- STL
1 stop22h 16m
Frontier
Deal found 2/20![Frontier logo]()
$84
This Trip.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:17 pm
JAX
- STL
1 stop11h 33m
Frontier
Deal found 2/20![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:18 pm
JAX
- STL
1 stop22h 16m
Frontier
Deal found 2/20![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:28 pm
JAX
- STL
1 stop12h 22m
Frontier
Deal found 2/19![Frontier logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:25 pm
JAX
- STL
1 stop13h 25m
Frontier
Deal found 2/19![Frontier logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:08 pm
JAX
- STL
1 stop13h 42m
Frontier
Deal found 2/20![Frontier logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:17 pm
JAX
- STL
2 stops23h 55m
Frontier
Deal found 2/20![Frontier logo]()
$113
Find flight deals from Jacksonville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Jacksonville (JAX) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $183 (Kiwi.com) |
One-way from | $71 (Trip.com) |
Popular in | March |
Cheapest in | July |
Average price | $350 |
Good round-trip deal | $361 or less |
Good one-way deal | $168 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Jacksonville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Jacksonville to St. Louis that are best for you.
Fly from
Jacksonville
Fly to
St. Louis
Route
Depart
Return
Price
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Thu 4/2
7:59 pm-11:58 pm
1 stop4h 59m
Lambert-St Louis
Sun 4/5
6:59 pm-11:59 pm
1 stop4h 00m
$299
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Fri 3/27
6:15 am-7:35 am
Nonstop2h 20m
Lambert-St Louis
Sun 3/29
5:25 am-12:10 pm
1 stop5h 45m
$302
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Fri 4/24
3:35 pm-4:50 pm
Nonstop2h 15m
Lambert-St Louis
Sun 4/26
8:20 am-3:50 pm
1 stop6h 30m
$311
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Thu 4/2
6:15 am-7:35 am
Nonstop2h 20m
Lambert-St Louis
Sun 4/5
2:15 pm-5:15 pm
Nonstop2h 00m
$314
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Fri 3/20
5:10 am-9:35 am
1 stop5h 25m
Lambert-St Louis
Mon 3/23
4:55 pm-12:05 am
1 stop6h 10m
$318
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Fri 4/10
6:05 am-12:50 pm
2 stops7h 45m
Lambert-St Louis
Sun 4/12
6:00 am-3:50 pm
1 stop8h 50m
$328
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Thu 3/26
5:50 am-12:30 pm
2 stops7h 40m
Lambert-St Louis
Tue 3/31
6:10 am-4:00 pm
2 stops8h 50m
$334
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Thu 3/12
5:50 am-12:30 pm
2 stops7h 40m
Lambert-St Louis
Sat 3/21
7:55 pm-10:55 pm
Nonstop2h 00m
$348
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Wed 3/4
10:58 am-4:58 pm
1 stop7h 00m
Lambert-St Louis
Fri 3/6
1:34 pm-7:17 pm
1 stop4h 43m
$351
JacksonvilleSt. Louis
JAX - STL
JAXSTL
Jacksonville
Tue 5/19
8:20 am-9:35 am
Nonstop2h 15m
$139
Showing 1-10 of 20 results
Compare providers for flights from Jacksonville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Jacksonville to St. Louis in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Jacksonville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Jacksonville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Jacksonville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Jacksonville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Jacksonville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Jacksonville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Jacksonville with our price prediction graph.
JAX-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Jacksonville to St. Louis
How far ahead should I book a flight from Jacksonville to St. Louis?
Use this chart to determine the optimal time to book a round-trip flight from Jacksonville to St. Louis. Price data was last updated on February 20, 2026.
The best time to book flights from Jacksonville to St. Louis is 29 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Jacksonville to St. Louis?
Currently, April is the cheapest month in which you can book a flight from Jacksonville to St. Louis (average of $139). Flying from Jacksonville to St. Louis in January is currently the most expensive (average of $262). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from JAX to STL?
Find hourly flight availability from Jacksonville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 23, 2026.
When flying from Jacksonville to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 15% versus a flight at noon.
What is the cheapest day to fly from Jacksonville to St. Louis?
Use this chart to determine the cheapest time to fly round-trip from Jacksonville to St. Louis. Price data was last updated on February 21, 2026.
Travelers seeking maximum savings on their Jacksonville to St. Louis flight should consider departing on Thursday evenings when fares are most often at their lowest. Wednesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
The best insider tips for Jacksonville to St. Louis flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Jacksonville to St. Louis trip
Our travel experts
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated February 23, 2026.
Read through reviews of airlines operating flights from Jacksonville to St. Louis, such as Southwest, Delta, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Entertainment
7.5
Crew
8.6
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Jacksonville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Swansea
Fairview Heights
Fenton
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Top 3 airlines flying from Jacksonville to St. Louis
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$176 | Average$316 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$214 | Average$310 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$218 | Average$288 | FlexibilityNo cancel fee | On-time71% |