$59+ Cheap flights from Jacksonville to St. Louis (JAX - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
JAX — STL
Nov 8 — Nov 151
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Jacksonville to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Jacksonville to Lambert-St Louis are usually found in February or April, booked 16 days in advance, depart on a Wednesday or Friday and return on a Tuesday
Cheap flight deals from Jacksonville to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Jacksonville to St. LouisExplore the most affordable flight options available from Jacksonville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
Explore the most affordable flight options available from Jacksonville to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:03 pm -
1 stop23h 39m
Mon 11/96:34 pm -
1 stop22h 37m
Deal found 10/5![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:03 pm -
1 stop23h 37m
Fri 10/306:44 pm -
1 stop22h 44m
Deal found 10/4![Frontier logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:10 pm -
2 stops28h 06m
Fri 11/136:34 pm -
1 stop22h 57m
Deal found 10/9![Frontier logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:03 pm -
2 stops17h 16m
Wed 11/116:34 pm -
1 stop22h 37m
Deal found 10/7![Frontier logo]()
$203
This CheapOair deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:03 pm -
1 stop23h 39m
Wed 11/116:34 pm -
1 stop22h 37m
Deal found 10/7![Frontier logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:03 pm -
1 stop23h 39m
Mon 11/96:34 pm -
2 stops20h 52m
Deal found 10/5![Multiple Airlines logo]()
$213
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:05 am -
Nonstop2h 15m
Tue 11/106:15 pm -
Nonstop2h 00m
Deal found 10/4![Southwest logo]()
$233
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:10 pm -
1 stop7h 15m
Wed 12/96:15 pm -
Nonstop1h 55m
Deal found 10/7![Southwest logo]()
$236
Best flights from Jacksonville to St. LouisDiscover carefully curated flight deals from Jacksonville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
Discover carefully curated flight deals from Jacksonville to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 9, 2026.
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:35 pm -
1 stop6h 45m
Mon 11/97:55 pm -
Nonstop2h 00m
Deal found 10/7![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/510:40 am -
1 stop6h 40m
Tue 12/811:45 am -
2 stops8h 30m
Deal found 10/7![Southwest logo]()
$244
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:45 am -
Nonstop2h 20m
Mon 11/97:55 pm -
Nonstop2h 00m
Deal found 10/5![Southwest logo]()
$245
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/114:55 pm -
1 stop5h 15m
Sun 11/157:55 pm -
Nonstop2h 00m
Deal found 10/8![Southwest logo]()
$291
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:45 am -
Nonstop2h 20m
Mon 11/97:55 pm -
Nonstop2h 00m
Deal found 10/4![Southwest logo]()
$316
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/136:50 am -
2 stops9h 10m
Mon 1/188:30 am -
1 stop9h 00m
Deal found 10/7![Southwest logo]()
$318
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:00 am -
Nonstop2h 20m
Sun 11/298:50 pm -
Nonstop1h 55m
Deal found 10/8![Southwest logo]()
$340
Last-minute flights from Jacksonville to St. LouisDiscover last-minute flight deals from Jacksonville to St. Louis. Data last updated October 9, 2026 and is based on user searches.
Discover last-minute flight deals from Jacksonville to St. Louis. Data last updated October 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:03 pm -
1 stop23h 37m
Fri 10/306:44 pm -
1 stop22h 44m
Deal found 10/4![Frontier logo]()
$137
This Southwest deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:05 am -
Nonstop2h 15m
Tue 11/106:15 pm -
Nonstop2h 00m
Deal found 10/4![Southwest logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:03 pm -
2 stops17h 16m
Wed 11/116:34 pm -
1 stop22h 37m
Deal found 10/7![Frontier logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:03 pm -
1 stop23h 39m
Mon 11/96:34 pm -
1 stop22h 37m
Deal found 10/5![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:03 pm -
1 stop23h 39m
Mon 11/96:34 pm -
2 stops20h 52m
Deal found 10/5![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:10 pm -
2 stops28h 06m
Fri 11/136:34 pm -
1 stop22h 57m
Deal found 10/9![Frontier logo]()
$196
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:55 am -
1 stop7h 25m
Wed 11/116:15 pm -
Nonstop2h 00m
Deal found 10/7![Southwest logo]()
$236
This CheapOair deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:03 pm -
1 stop23h 39m
Wed 11/116:34 pm -
1 stop22h 37m
Deal found 10/7![Frontier logo]()
$208
One-way flights from Jacksonville to St. LouisSearch for one-way flight options from Jacksonville to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
Search for one-way flight options from Jacksonville to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:03 pm -
1 stop23h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Frontier logo]()
$59
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/83:56 pm -
1 stop20h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Frontier logo]()
$60
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:03 pm -
1 stop23h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Frontier logo]()
$64
This Trip.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:59 pm -
1 stop24h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![Frontier logo]()
$70
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:55 pm -
1 stop18h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/5![Frontier logo]()
$72
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:03 pm -
1 stop23h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![Frontier logo]()
$80
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:03 pm -
1 stop23h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![Frontier logo]()
$85
Find flight deals from Jacksonville to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Jacksonville (JAX) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $116 (Kiwi.com) |
One-way from | $59 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $376 |
Good round-trip deal | $356 or less |
Good one-way deal | $174 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Jacksonville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
Use the filters below to find and compare flights from Jacksonville to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Tue 12/8
6:05 am-7:20 am
Nonstop2h 15m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$117
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Thu 1/7
6:50 am-3:00 pm
2 stops9h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$125
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Mon 12/7
9:45 am-1:28 pm
1 stop4h 43m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$126
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Thu 1/7
5:30 am-8:52 am
1 stop4h 22m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$126
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Sat 11/7
12:58 pm-4:28 pm
1 stop4h 30m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$126
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Tue 11/3
6:35 am-1:45 pm
2 stops8h 10m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$138
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Tue 12/1
4:45 pm-10:59 pm
1 stop7h 14m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$170
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Mon 11/9
6:00 am-3:43 pm
2 stops10h 43m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$175
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Wed 1/6
5:30 am-10:48 am
1 stop6h 18m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$184
JacksonvilleSt. Louis
JAX Jacksonville - STL Lambert-St Louis
JAXSTL
Jacksonville
Tue 4/6
5:05 pm-8:49 pm
1 stop4h 44m
Lambert-St Louis
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$184
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Jacksonville to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Jacksonville to St. Louis in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Jacksonville-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Jacksonville-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Jacksonville-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Jacksonville-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Jacksonville-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Jacksonville to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Jacksonville with our price prediction graph.
JAX-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Jacksonville to St. Louis
How far ahead should I book a flight from Jacksonville to St. Louis?
The best time to book flights from Jacksonville to St. Louis is 15 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Jacksonville to St. Louis?
Currently, February is the cheapest month in which you can book a flight from Jacksonville to St. Louis (average of $350). Flying from Jacksonville to St. Louis in March is currently the most expensive (average of $443). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from JAX to STL?
Find hourly flight availability from Jacksonville to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 9, 2026.
When flying from Jacksonville to St. Louis, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 15% versus a flight in the morning.
The best insider tips for Jacksonville to St. Louis flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Jacksonville to St. Louis trip
Our travel experts
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 9, 2026.
Read through reviews of airlines operating flights from Jacksonville to St. Louis, such as Southwest,Delta, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Entertainment
7.4
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Overall
7.9
Entertainment
7.4
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Overall
7.9
Entertainment
7.4
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Overall
7.9
Entertainment
7.4
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Related info for your journey
Find useful and relevant information for your journey from Jacksonville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Chesterfield
Maryland Heights
Collinsville
Edwardsville
Glencoe
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Jacksonville
Popular flights
St. Louis flight routes
Alternative routes for Jacksonville to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Jacksonville to St. Louis by cabin class
Find flights from Jacksonville to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Jacksonville and St. Louis flights
Browse other Jacksonville and St. Louis flight options. Last updated on October 9, 2026.
Other flights from Jacksonville
Browse through other flights departing from Jacksonville. Flights are based on user searches made on Cheapflights and were last updated on October 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 9, 2026.
Top 3 airlines flying from Jacksonville to St. Louis
Discover the top 3 airlines that operate flights from Jacksonville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$256 | Average$376 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$274 | Average$379 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$278 | Average$377 | FlexibilityNo cancel fee | On-time63% |