HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
St. Louis

$405+ Cheap flights from Florence, SC to St. Louis (FLO - STL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/8. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — STL
Jun 14 — Jun 211
Sun 6/14
Sun 6/21
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florence to St. Louis with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florence to St. Louis

Cheapest flights from Florence to St. Louis
Explore the most affordable flight options available from Florence to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 15, 2026.

This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/82:37 pm
FLO
-
STL
1 stop3h 57m
American Airlines
Tue 8/1110:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$405
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:35 pm
FLO
-
STL
1 stop3h 45m
American Airlines
Tue 6/27:30 am
STL
-
FLO
1 stop5h 40m
American Airlines
Deal found 5/14$419
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:09 am
FLO
-
STL
1 stop4h 22m
American Airlines
Sat 8/86:25 pm
STL
-
FLO
1 stop4h 33m
American Airlines
Deal found 5/12$438
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:24 am
FLO
-
STL
1 stop4h 08m
American Airlines
Sun 8/99:21 am
STL
-
FLO
1 stop3h 51m
American Airlines
Deal found 5/14$453
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:37 pm
FLO
-
STL
1 stop3h 57m
American Airlines
Mon 8/1010:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$471
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:24 am
FLO
-
STL
1 stop4h 08m
American Airlines
Tue 8/1110:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$474
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:24 am
FLO
-
STL
1 stop4h 08m
American Airlines
Tue 8/1110:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$502
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:37 pm
FLO
-
STL
1 stop3h 57m
American Airlines
Sun 8/99:21 am
STL
-
FLO
1 stop3h 51m
American Airlines
Deal found 5/12$507
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:24 am
FLO
-
STL
1 stop4h 08m
American Airlines
Mon 8/1010:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$535

Find flight deals from Florence to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$405
Provider with most accurate pricing for Florence-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Lambert-St Louis flights.
Search Deals
From Florence to Lambert-St Louis
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from Florence to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 5/29

2:35 pm-5:20 pm

1 stop3h 45m

Lambert-St Louis

Tue 6/2

7:30 am-2:10 pm

1 stop5h 40m

$419

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Thu 8/6

5:09 am-8:31 am

1 stop4h 22m

Lambert-St Louis

Sat 8/8

6:25 pm-11:58 pm

1 stop4h 33m

$438

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 8/7

6:24 am-9:32 am

1 stop4h 08m

Lambert-St Louis

Sun 8/9

7:34 am-2:12 pm

1 stop5h 38m

$453

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 8/7

6:24 am-9:32 am

1 stop4h 08m

Lambert-St Louis

Sat 8/8

7:34 am-2:12 pm

1 stop5h 38m

$474
Quickest round-trip

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Wed 8/5

6:24 am-9:32 am

1 stop4h 08m

Lambert-St Louis

Mon 8/10

10:22 am-2:56 pm

1 stop3h 34m

$535

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Sun 8/9

5:09 am-8:31 am

1 stop4h 22m

Lambert-St Louis

Tue 8/11

8:34 am-2:56 pm

1 stop5h 22m

$941

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Thu 8/6

5:09 am-8:31 am

1 stop4h 22m

Lambert-St Louis

Fri 8/7

8:34 am-2:56 pm

1 stop5h 22m

$955

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/14

Sorted by cheapest first

Compare providers for flights from Florence to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to St. Louis in May.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Florence, South Carolina-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Florence to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to St. Louis?

    American Airlines can get you from Florence, South Carolina to St. Louis in just under 3h 45m. Your travel time can differ by up to . Florence, South Carolina and St. Louis are separated by a distance of 669 mi.

  • Can I find deals for flights from Florence to St. Louis that include hotel bookings?

    Yes. In addition to deals on Florence to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to St. Louis.

  • Can I find deals for business class flights from Florence to St. Louis?

    Yes. Cheapflights offers flight deals from Florence to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.