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$39+ Cheap flights from Des Moines to St. Louis (DSM - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Oct 25 — Nov 11
Sat 10/25
Sat 11/1
1 adult, Economy
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Cheap flight deals from Des Moines to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 25, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$87
(Southwest)

One-way from

$39
(Southwest)

Popular in

July

Cheapest in

August

Average price

$233

Good round-trip deal

$286 or less

Good one-way deal

$167 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
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From Des Moines to Lambert-St Louis
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One-way flight from Des Moines to Lambert-St Louis
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Highest demand for flights based on searches. 9% potential increase in price ($34 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Des Moines to Lambert-St Louis.
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Price to beat on a one-way flight from Des Moines to Lambert-St Louis.
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Find flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. Louis
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2025.

This Southwest deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:15 pmDSM - STL
Nonstop1h 10mSouthwest
Mon 10/2710:20 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/22$77
This Southwest deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/234:35 pmDSM - STL
1 stop7h 15mSouthwest
Thu 10/3010:20 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/25$87
This Southwest deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2810:15 amDSM - STL
2 stops7h 10mSouthwest
Thu 10/3010:20 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 9/23$92
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/276:07 pmDSM - STL
1 stop5h 47mAmerican Airlines
Thu 10/307:16 amSTL - DSM
1 stop6h 02mAmerican Airlines
Deal found 9/23$159
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:05 amDSM - STL
1 stop7h 17mDelta
Thu 10/306:00 amSTL - DSM
1 stop4h 26mDelta
Deal found 9/25$177
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:05 amDSM - STL
1 stop7h 17mDelta
Sat 10/254:45 pmSTL - DSM
1 stop4h 18mDelta
Deal found 9/22$184
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/811:06 amDSM - STL
1 stop4h 25mDelta
Sat 11/155:34 pmSTL - DSM
1 stop3h 41mDelta
Deal found 9/24$191
This Booking.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/52:25 pmDSM - STL
1 stop18h 41mFrontier
Thu 10/97:52 pmSTL - DSM
1 stop18h 00mFrontier
Deal found 9/22$200
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/168:00 amDSM - STL
1 stop6h 27mUnited Airlines
Thu 10/235:00 amSTL - DSM
1 stop5h 32mUnited Airlines
Deal found 9/25$217

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Des Moines

Fly to

St. Louis

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 10/27

6:15 pm-7:25 pm

Nonstop1h 10m

Lambert-St Louis

Thu 10/30

10:20 pm-11:30 pm

Nonstop1h 10m

$77

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 10/29

6:20 am-7:30 am

Nonstop1h 10m

Lambert-St Louis

Wed 10/29

1:30 pm-8:55 pm

1 stop7h 25m

$87

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 10/23

6:05 am-1:22 pm

1 stop7h 17m

Lambert-St Louis

Thu 10/30

6:00 am-10:26 am

1 stop4h 26m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 10/20

5:32 pm-11:24 pm

1 stop5h 52m

Lambert-St Louis

Mon 10/27

3:30 pm-9:03 pm

1 stop5h 33m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 10/23

6:05 am-1:22 pm

1 stop7h 17m

Lambert-St Louis

Sat 10/25

4:45 pm-9:03 pm

1 stop4h 18m

$184

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 11/8

5:47 am-12:35 pm

1 stop6h 48m

Lambert-St Louis

Sat 11/15

5:34 pm-9:15 pm

1 stop3h 41m

$191

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 10/20

6:15 pm-7:25 pm

Nonstop1h 10m

Lambert-St Louis

Mon 10/27

4:40 pm-9:35 pm

1 stop4h 55m

$203

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 12/4

6:15 am-7:25 am

Nonstop1h 10m

$39

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 12/2

6:15 am-7:25 am

Nonstop1h 10m

$39

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 10/27

6:15 pm-7:25 pm

Nonstop1h 10m

$39

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/25

Showing 1-10 of 16 results
1
2

Compare providers for flights from Des Moines to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in September.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to St. Louis

What is the cheapest month to book a flight from Des Moines to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Des Moines to St. Louis (average of $311). Flying from Des Moines to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to STL?

Find hourly flight availability from Des Moines to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 25, 2025.

One of the essential ways to save on airfare from Des Moines to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 4% on airfare.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 25, 2025.
See what other customers who have flown with Southwest from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Food

7.0

Entertainment

7.5

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Crew

8.6

Food

7.0

Entertainment

7.5

Comfort

8.0

Overall

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Des Moines to St. Louis?

    Lambert-St Louis is the airport most travelers will use when flying to St. Louis from Des Moines. Booking flights from Des Moines (DSM) to Lambert-St Louis (STL) should be relatively easy as there is 1 daily flight to St. Louis from 1 airline. 1h 05m is how long a flight from Des Moines to Lambert-St Louis will take if you book a nonstop flight.

  • How popular is this Des Moines to St. Louis flight route?

    This flight path from Des Moines to Lambert-St Louis was viewed by 30 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to St. Louis?

    A quick flight from Des Moines to St. Louis can take about 1h 10m. Southwest provides one of the quickest options available for as low as $77. Airlines will cover a distance of 259 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Des Moines to St. Louis round-trip?

    Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $97. Users have found that Southwest is 70% cheaper than the other options available to this destination.

  • What are the cheapest flights from Des Moines to St. Louis?

    While on average a flight from Des Moines to St. Louis is generally $288, our data shows the cheapest flight currently is $78. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $154 for that flight.

  • Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

    Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.

  • Can I find deals for business class flights from Des Moines to St. Louis?

    Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to St. Louis (average of $311). Flying from Des Moines to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Des Moines to St. Louis

Discover the top airline that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$297FlexibilityNo cancel feeOn-time63%

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