$49+ Cheap flights from Des Moines to St. Louis (DSM - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/12. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Des Moines to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated junio 12, 2025.
Round-trip from | $97 (Southwest) |
|---|---|
One-way from | $49 (Southwest) |
Popular in | September |
Cheapest in | August |
Average price | $309 |
Good round-trip deal | $317 or less |
Good one-way deal | $173 or less |
Find flight deals from Des Moines to St. Louis
Cheapest flights from Des Moines to St. LouisExplore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
mar. 8/12
8:25 am-9:30 am
Nonstop1h 05m
Lambert-St Louis
jue. 8/14
9:40 pm-10:50 pm
Nonstop1h 10m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
mar. 8/12
5:25 pm-11:22 pm
1 stop5h 57m
Lambert-St Louis
jue. 8/14
5:11 pm-10:39 pm
1 stop5h 28m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
lun. 8/11
3:20 pm-8:18 pm
1 stop4h 58m
Lambert-St Louis
mié. 8/13
8:40 am-4:48 pm
1 stop8h 08m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
mié. 8/13
6:50 pm-10:45 pm
1 stop3h 55m
Lambert-St Louis
sáb. 8/16
4:45 pm-11:59 pm
1 stop7h 14m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
jue. 7/24
6:32 pm-6:41 pm
2 stops24h 09m
Lambert-St Louis
dom. 7/27
10:47 am-6:06 pm
2 stops31h 19m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
mar. 8/12
8:25 am-9:30 am
Nonstop1h 05m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
mié. 9/10
6:12 pm-10:50 pm
1 stop4h 38m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
mar. 8/5
11:25 am-3:47 pm
1 stop4h 22m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
mié. 8/27
7:00 am-1:20 pm
2 stops6h 20m
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
dom. 7/20
6:32 pm-6:41 pm
2 stops24h 09m
Best time to book a flight from Des Moines to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to St. Louis
What is the cheapest month to book a flight from Des Moines to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Des Moines to St. Louis (average of $311). Flying from Des Moines to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to STL?
Find hourly flight availability from Des Moines to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.
One of the essential ways to save on airfare from Des Moines to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 4% on airfare.
Rainfall in St. Louis by month
Plan your trip to St. Louis by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.
Temperature in St. Louis by month
Plan your trip to St. Louis by taking into account the average temperature totals by month.
If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated junio 12, 2025.
Read reviews from past customers who have flown Southwest, Delta and United Airlines from Des Moines to St. Louis. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
Entertainment
Overall
Boarding
Comfort
Crew
Reviews
John,May 2025
PVD - BNA
Food
Entertainment
Overall
Boarding
Comfort
Crew
Reviews
John,May 2025
PVD - BNA
Food
Entertainment
Overall
Boarding
Comfort
Crew
Reviews
John,May 2025
PVD - BNA
Food
Entertainment
Overall
Boarding
Comfort
Crew
Reviews
John,May 2025
PVD - BNA
Food
Entertainment
Overall
Boarding
Comfort
Crew
Reviews
John,May 2025
PVD - BNA
Food
Entertainment
Overall
Boarding
Comfort
Crew
Reviews
John,May 2025
PVD - BNA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
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Alternative routes for Des Moines to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Top 2 airlines flying from Des Moines to St. Louis
Discover the top 2 airlines that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$117 | Average$310 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$258 | Average$379 | FlexibilityNo cancel fee | On-time69% |