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$39+ Cheap flights from Des Moines to St. Louis (DSM - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Des Moines to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$77
(Southwest)

One-way from

$39
(Southwest)

Popular in

July

Cheapest in

September

Average price

$249

Good round-trip deal

$257 or less

Good one-way deal

$180 or less
From Des Moines to Lambert-St Louis
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One-way flight from Des Moines to Lambert-St Louis
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Highest demand for flights based on searches. 11% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from Des Moines to Lambert-St Louis.
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Price to beat on a one-way flight from Des Moines to Lambert-St Louis.
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Find flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. Louis
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:00 amDSM - STL
Nonstop1h 05mSouthwest
Thu 9/189:40 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 8/12$77
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/274:20 pmDSM - STL
1 stop4h 12mAmerican Airlines
Sat 10/42:01 pmSTL - DSM
1 stop6h 20mAmerican Airlines
Deal found 8/13$158
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/192:25 pmDSM - STL
1 stop18h 41mFrontier
Sun 9/217:55 pmSTL - DSM
1 stop17h 45mFrontier
Deal found 8/14$171
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/92:12 pmDSM - STL
1 stop4h 55mDelta
Thu 9/116:00 amSTL - DSM
1 stop4h 14mDelta
Deal found 8/12$177
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/92:12 pmDSM - STL
1 stop7h 50mDelta
Tue 9/166:40 amSTL - DSM
2 stops10h 33mDelta
Deal found 8/12$182
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/182:25 pmDSM - STL
1 stop18h 41mFrontier
Sun 9/217:55 pmSTL - DSM
1 stop17h 45mFrontier
Deal found 8/14$190
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/191:10 pmDSM - STL
1 stop5h 13mUnited Airlines
Sun 9/215:30 pmSTL - DSM
1 stop4h 15mUnited Airlines
Deal found 8/12$219
This FlightHub deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/253:08 pmDSM - STL
1 stop18h 03mFrontier
Wed 8/277:54 pmSTL - DSM
1 stop18h 29mFrontier
Deal found 8/12$225
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:38 pmDSM - STL
1 stop5h 29mAmerican Airlines
Fri 10/39:57 amSTL - DSM
1 stop6h 52mAmerican Airlines
Deal found 8/12$239
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/286:30 amDSM - STL
1 stop5h 27mAmerican Airlines
Sun 10/58:03 pmSTL - DSM
1 stop3h 25mAmerican Airlines
Deal found 8/14$240

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Des Moines

Fly to

St. Louis

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/11

6:00 am-7:05 am

Nonstop1h 05m

Lambert-St Louis

Thu 9/18

9:40 pm-10:50 pm

Nonstop1h 10m

$77

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 9/27

4:20 pm-8:32 pm

1 stop4h 12m

Lambert-St Louis

Sat 10/4

2:01 pm-8:21 pm

1 stop6h 20m

$158

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 9/9

7:03 am-1:23 pm

1 stop6h 20m

Lambert-St Louis

Tue 9/16

1:53 pm-6:30 pm

1 stop4h 37m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 9/15

6:09 pm-11:48 pm

1 stop5h 39m

Lambert-St Louis

Wed 9/17

6:10 am-9:46 am

1 stop3h 36m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 9/19

2:25 pm-9:06 am

1 stop18h 41m

Lambert-St Louis

Sun 9/21

7:55 pm-1:40 pm

1 stop17h 45m

$171

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 9/9

2:12 pm-7:07 pm

1 stop4h 55m

Lambert-St Louis

Thu 9/11

6:00 am-10:14 am

1 stop4h 14m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/11

6:30 pm-11:24 pm

1 stop4h 54m

Lambert-St Louis

Thu 9/18

6:00 am-10:14 am

1 stop4h 14m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 9/26

6:30 pm-11:24 pm

1 stop4h 54m

Lambert-St Louis

Fri 10/3

6:00 am-10:14 am

1 stop4h 14m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 9/9

2:12 pm-10:02 pm

1 stop7h 50m

Lambert-St Louis

Tue 9/16

6:40 am-5:13 pm

2 stops10h 33m

$182

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/18

5:30 pm-6:35 pm

Nonstop1h 05m

$39

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 16 results
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Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to St. Louis

What is the cheapest month to book a flight from Des Moines to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Des Moines to St. Louis (average of $311). Flying from Des Moines to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to STL?

Find hourly flight availability from Des Moines to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

One of the essential ways to save on airfare from Des Moines to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 4% on airfare.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated August 14, 2025.
See what other customers who have flown with Southwest from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,244 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Des Moines to St. Louis?

    Lambert-St Louis is the airport most travelers will use when flying to St. Louis from Des Moines. Booking flights from Des Moines (DSM) to Lambert-St Louis (STL) should be relatively easy as there is 1 daily flight to St. Louis from 1 airline. 1h 05m is how long a flight from Des Moines to Lambert-St Louis will take if you book a nonstop flight.

  • How popular is this Des Moines to St. Louis flight route?

    This flight path from Des Moines to Lambert-St Louis was viewed by 30 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What is the cheapest airline to fly from Des Moines to St. Louis round-trip?

    Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $97. Users have found that Southwest is 70% cheaper than the other options available to this destination.

  • What are the cheapest flights from Des Moines to St. Louis?

    While on average a flight from Des Moines to St. Louis is generally $276, our data shows the cheapest flight currently is $98. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $77 for that flight.

  • Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

    Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.

  • Can I find deals for business class flights from Des Moines to St. Louis?

    Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to St. Louis (average of $311). Flying from Des Moines to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
St. Peters
Glencoe
Alton
Chesterfield
Farmington
Festus

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Top airline flying from Des Moines to St. Louis

Discover the top airline that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$309FlexibilityNo cancel feeOn-time63%

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