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St. Louis

$59+ Cheap flights from Des Moines to St. Louis (DSM - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Mar 15 — Mar 221
Sun 3/15
Sun 3/22
1 adult, Economy
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Cheap flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. Louis
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.

This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:55 pm
DSM
-
STL
1 stop9h 25m
Southwest
Mon 4/135:40 am
STL
-
DSM
1 stop6h 05m
Southwest
Deal found 2/11$149
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:01 pm
DSM
-
STL
1 stop5h 16m
American Airlines
Mon 5/48:03 pm
STL
-
DSM
1 stop3h 46m
American Airlines
Deal found 2/11$181
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2810:04 am
DSM
-
STL
1 stop3h 46m
American Airlines
Sat 4/45:12 am
STL
-
DSM
1 stop5h 32m
American Airlines
Deal found 2/11$182
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:44 pm
DSM
-
STL
1 stop4h 04m
American Airlines
Sun 3/85:12 am
STL
-
DSM
1 stop5h 22m
American Airlines
Deal found 2/12$188
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:09 am
DSM
-
STL
1 stop5h 32m
American Airlines
Mon 5/45:46 am
STL
-
DSM
1 stop4h 40m
American Airlines
Deal found 2/11$189
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:55 am
DSM
-
STL
1 stop4h 53m
Delta
Sat 4/43:05 pm
STL
-
DSM
1 stop6h 05m
Delta
Deal found 2/11$191
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:44 pm
DSM
-
STL
1 stop3h 51m
American Airlines
Sat 3/75:12 am
STL
-
DSM
1 stop5h 32m
American Airlines
Deal found 2/10$193
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:44 pm
DSM
-
STL
1 stop3h 51m
American Airlines
Sun 3/85:12 am
STL
-
DSM
1 stop5h 22m
American Airlines
Deal found 2/12$195
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:20 pm
DSM
-
STL
1 stop6h 50m
Southwest
Mon 3/304:45 pm
STL
-
DSM
1 stop6h 30m
Southwest
Deal found 2/10$196
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:57 am
DSM
-
STL
1 stop3h 57m
Delta
Thu 3/56:10 am
STL
-
DSM
1 stop4h 07m
Delta
Deal found 2/12$198
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/310:57 am
DSM
-
STL
1 stop5h 48m
Delta
Wed 3/46:10 am
STL
-
DSM
1 stop4h 07m
Delta
Deal found 2/12$205
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:44 pm
DSM
-
STL
1 stop4h 04m
American Airlines
Sun 3/19:20 am
STL
-
DSM
1 stop3h 45m
American Airlines
Deal found 2/12$206

Find flight deals from Des Moines to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$149
(Southwest)

One-way from

$59
(Southwest)

Popular in

July

Cheapest in

September

Average price

$486

Good round-trip deal

$348 or less

Good one-way deal

$187 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
Search Deals
From Des Moines to Lambert-St Louis
Search Deals
One-way flight from Des Moines to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Des Moines to Lambert-St Louis.
Search Deals
Price to beat on a one-way flight from Des Moines to Lambert-St Louis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Des Moines

Fly to

St. Louis

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 5/2

5:01 pm-10:17 pm

1 stop5h 16m

Lambert-St Louis

Mon 5/4

8:03 pm-11:49 pm

1 stop3h 46m

$181

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 3/5

7:44 pm-11:48 pm

1 stop4h 04m

Lambert-St Louis

Sun 3/8

5:12 am-10:34 am

1 stop5h 22m

$188

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 3/28

6:55 am-11:48 am

1 stop4h 53m

Lambert-St Louis

Sat 4/4

3:05 pm-9:10 pm

1 stop6h 05m

$191

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 3/6

7:44 pm-11:35 pm

1 stop3h 51m

Lambert-St Louis

Sun 3/8

5:12 am-10:34 am

1 stop5h 22m

$195

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 3/26

4:20 pm-11:10 pm

1 stop6h 50m

Lambert-St Louis

Mon 3/30

4:45 pm-11:15 pm

1 stop6h 30m

$196

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/31

6:55 am-12:58 pm

2 stops6h 03m

Lambert-St Louis

Mon 4/13

5:35 pm-9:08 pm

1 stop3h 33m

$196

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 3/4

10:57 am-2:54 pm

1 stop3h 57m

Lambert-St Louis

Thu 3/5

6:10 am-10:17 am

1 stop4h 07m

$198

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 3/3

10:57 am-2:54 pm

1 stop3h 57m

Lambert-St Louis

Thu 3/5

6:10 am-10:17 am

1 stop4h 07m

$198

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 2/25

6:55 pm-10:59 pm

1 stop4h 04m

Lambert-St Louis

Sun 3/1

6:25 am-10:53 am

1 stop4h 28m

$205

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 3/29

3:21 pm-9:08 pm

1 stop5h 47m

Lambert-St Louis

Mon 3/30

9:10 am-2:25 pm

1 stop5h 15m

$211

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/12

Showing 1-10 of 20 results
1
2

Compare providers for flights from Des Moines to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to St. Louis

What is the cheapest time of day to fly from DSM to STL?

Find hourly flight availability from Des Moines to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 13, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to St. Louis as you normally would.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated February 13, 2026.
See what other customers who have flown with Southwest from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,283 reviews

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,283 reviews
Southwest
8.0
Very good
4,283 reviews

Boarding

8.1

Comfort

8.0

Entertainment

7.5

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Des Moines to St. Louis?

    Lambert-St Louis is the airport most travelers will use when flying to St. Louis from Des Moines. Booking flights from Des Moines (DSM) to Lambert-St Louis (STL) should be relatively easy as there is 1 daily flight to St. Louis from 1 airline. 1h 05m is how long a flight from Des Moines to Lambert-St Louis will take if you book a nonstop flight.

  • How popular is this Des Moines to St. Louis flight route?

    This flight path from Des Moines to Lambert-St Louis was viewed by 21 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to St. Louis?

    A quick flight from Des Moines to St. Louis can take about 4h 53m. American Airlines provides one of the quickest options available for as low as $191. Airlines will cover a distance of 259 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Des Moines to St. Louis round-trip?

    Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $97. Users have found that Southwest is 69% cheaper than the other options available to this destination.

  • What are the cheapest flights from Des Moines to St. Louis?

    While on average a flight from Des Moines to St. Louis is generally $318, our data shows the cheapest flight currently is $131. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $187 for that flight.

  • Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

    Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.

  • Can I find deals for business class flights from Des Moines to St. Louis?

    Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Des Moines to St. Louis

Discover the top airline that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$253FlexibilityNo cancel feeOn-time63%

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