How popular is this Des Moines to St. Louis flight route?

This flight path from Des Moines to Lambert-St Louis was viewed by 29 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Des Moines to St. Louis?

A quick flight from Des Moines to St. Louis can take about 4h 04m. Delta provides one of the quickest options available for as low as $159. Airlines will cover a distance of 259 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What is the cheapest airline to fly from Des Moines to St. Louis round-trip?

Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $97. Users have found that Southwest is 70% cheaper than the other options available to this destination.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What are the cheapest flights from Des Moines to St. Louis?

While on average a flight from Des Moines to St. Louis is generally $341, our data shows the cheapest flight currently is $128. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $159 for that flight.

Most accurate provider : When it comes to deals on Des Moines-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airports do I use to fly from Des Moines to St. Louis?

Lambert-St Louis is the airport most travelers will use when flying to St. Louis from Des Moines. Booking flights from Des Moines (DSM) to Lambert-St Louis (STL) should be relatively easy as there is 1 daily flight to St. Louis from 1 airline. 1h 05m is how long a flight from Des Moines to Lambert-St Louis will take if you book a nonstop flight.

Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.

Can I find deals for business class flights from Des Moines to St. Louis?

Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$71+ Flights from Des Moines to St. Louis

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1. Tell us where you want to go

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Cheap flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. Louis
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.

Tue 12/306:52 pmDSM - STL

1 stop4h 52mAmerican Airlines

Wed 12/315:16 amSTL - DSM

1 stop7h 08mAmerican Airlines

Deal found 12/28

$521

Wed 12/313:14 pmDSM - STL

1 stop4h 04mUnited Airlines

Thu 1/19:55 amSTL - DSM

1 stop4h 38mUnited Airlines

Deal found 12/29

$555

Wed 12/3112:10 pmDSM - STL

2 stops8h 31mDelta

Fri 1/27:00 amSTL - DSM

1 stop6h 38mDelta

Deal found 12/28

$718

Wed 12/316:15 amDSM - STL

Nonstop1h 10mSouthwest

Fri 1/25:15 pmSTL - DSM

1 stop5h 55mSouthwest

Deal found 12/28

$725

Mon 12/296:35 amDSM - STL

1 stop5h 45mSouthwest

Tue 12/303:45 pmSTL - DSM

2 stops7h 25mSouthwest

Deal found 12/28

$730

Wed 12/3112:10 pmDSM - STL

2 stops8h 31mDelta

Thu 1/17:00 amSTL - DSM

1 stop5h 28mDelta

Deal found 12/29

$738

Wed 12/316:15 amDSM - STL

Nonstop1h 10mSouthwest

Thu 1/18:25 pmSTL - DSM

Nonstop1h 10mSouthwest

Deal found 12/29

$907

Tue 12/308:30 amDSM - STL

1 stop12h 55mMultiple Airlines

Wed 12/314:50 pmSTL - DSM

2 stops45h 10mMultiple Airlines

Deal found 12/28

$1,125

Best flights from Des Moines to St. Louis
Discover carefully curated flight deals from Des Moines to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 29, 2025.

Wed 2/1110:30 amDSM - STL

1 stop6h 15mDelta

Wed 2/186:00 amSTL - DSM

1 stop5h 19mDelta

Deal found 12/27

$159

Thu 2/127:44 pmDSM - STL

1 stop4h 04mAmerican Airlines

Thu 2/196:36 pmSTL - DSM

1 stop5h 04mAmerican Airlines

Deal found 12/29

$159

Wed 1/2110:30 amDSM - STL

1 stop6h 15mDelta

Sat 1/246:10 amSTL - DSM

1 stop4h 09mDelta

Deal found 12/28

$159

Mon 1/264:00 pmDSM - STL

1 stop6h 55mAmerican Airlines

Mon 2/23:37 pmSTL - DSM

1 stop7h 46mAmerican Airlines

Deal found 12/29

$159

Thu 1/2210:59 amDSM - STL

1 stop5h 46mDelta

Mon 1/263:45 pmSTL - DSM

1 stop6h 44mDelta

Deal found 12/27

$159

Wed 1/1412:04 pmDSM - STL

1 stop4h 33mDelta

Thu 1/156:35 amSTL - DSM

1 stop4h 49mDelta

Deal found 12/27

$159

Tue 2/1012:25 pmDSM - STL

1 stop4h 12mDelta

Tue 2/175:29 pmSTL - DSM

1 stop3h 51mDelta

Deal found 12/28

$159

Mon 1/2610:59 amDSM - STL

2 stops9h 44mDelta

Mon 2/26:10 amSTL - DSM

1 stop4h 09mDelta

Deal found 12/29

$214

Last-minute flights from Des Moines to St. Louis
Discover last-minute flight deals from Des Moines to St. Louis. Data last updated December 29, 2025 and is based on user searches.

Fri 1/911:35 amDSM - STL

1 stop4h 39mAmerican Airlines

Sun 1/113:37 pmSTL - DSM

1 stop7h 46mAmerican Airlines

Deal found 12/28

$404

Wed 1/1412:04 pmDSM - STL

1 stop4h 33mDelta

Thu 1/156:35 amSTL - DSM

1 stop4h 49mDelta

Deal found 12/27

$159

Wed 1/146:10 amDSM - STL

Nonstop1h 20mSouthwest

Thu 1/153:00 pmSTL - DSM

1 stop6h 20mSouthwest

Deal found 12/27

$439

Sun 1/188:00 amDSM - STL

1 stop6h 30mUnited Airlines

Tue 1/204:15 pmSTL - DSM

1 stop7h 29mUnited Airlines

Deal found 12/29

$274

Wed 1/213:20 pmDSM - STL

Nonstop1h 15mSouthwest

Sat 1/241:45 pmSTL - DSM

Nonstop1h 10mSouthwest

Deal found 12/28

$267

Thu 1/2210:59 amDSM - STL

2 stops9h 44mDelta

Mon 1/266:00 amSTL - DSM

1 stop4h 41mDelta

Deal found 12/27

$164

Mon 1/2610:59 amDSM - STL

2 stops9h 44mDelta

Mon 2/26:10 amSTL - DSM

1 stop4h 09mDelta

Deal found 12/29

$214

Mon 1/266:48 pmDSM - STL

2 stops14h 34mUnited Airlines

Mon 2/24:15 pmSTL - DSM

1 stop7h 29mUnited Airlines

Deal found 12/29

$447

One-way flights from Des Moines to St. Louis
Search for one-way flight options from Des Moines to St. Louis. Find affordable one-way fares based on user searches. Data last updated December 29, 2025.

Fri 2/277:59 pmDSM - STL

1 stop17h 57mFrontier

Deal found 12/28

$71

Wed 1/2812:25 pmDSM - STL

1 stop4h 12mDelta

Deal found 12/28

$80

Tue 1/1310:59 amDSM - STL

2 stops9h 44mDelta

Deal found 12/27

$85

Sun 1/255:16 pmDSM - STL

1 stop6h 21mDelta

Deal found 12/29

$90

Thu 2/267:27 pmDSM - STL

1 stop17h 42mFrontier

Deal found 12/29

$104

Tue 1/273:20 pmDSM - STL

Nonstop1h 15mSouthwest

Deal found 12/28

$127

Thu 2/127:32 pmDSM - STL

1 stop17h 37mFrontier

Deal found 12/28

$147

Mon 1/262:08 pmDSM - STL

3 stops57h 25mMultiple Airlines

Deal found 12/28

$164

Find flight deals from Des Moines to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$159 (Delta)
One-way from	$71 (Kiwi.com)
Popular in	July
Cheapest in	September
Average price	$407
Good round-trip deal	$377 or less
Good one-way deal	$199 or less

Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.

Search Deals

From Des Moines to Lambert-St Louis

Search Deals

One-way flight from Des Moines to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($35 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 8% potential price decrease ($25 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Price to beat on a round-trip flight from Des Moines to Lambert-St Louis.

Search Deals

Price to beat on a one-way flight from Des Moines to Lambert-St Louis.

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 2/11

10:30 am-4:45 pm

1 stop6h 15m

Lambert-St Louis

Wed 2/18

6:00 am-11:19 am

1 stop5h 19m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 2/12

7:44 pm-11:48 pm

1 stop4h 04m

Lambert-St Louis

Thu 2/19

6:36 pm-11:40 pm

1 stop5h 04m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/21

10:30 am-4:45 pm

1 stop6h 15m

Lambert-St Louis

Sat 1/24

6:10 am-10:19 am

1 stop4h 09m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 1/26

4:00 pm-10:55 pm

1 stop6h 55m

Lambert-St Louis

Mon 2/2

3:37 pm-11:23 pm

1 stop7h 46m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/22

10:59 am-4:45 pm

1 stop5h 46m

Lambert-St Louis

Mon 1/26

3:45 pm-10:29 pm

1 stop6h 44m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/14

12:04 pm-4:37 pm

1 stop4h 33m

Lambert-St Louis

Thu 1/15

6:35 am-11:24 am

1 stop4h 49m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 2/10

12:25 pm-4:37 pm

1 stop4h 12m

Lambert-St Louis

Tue 2/17

5:29 pm-9:20 pm

1 stop3h 51m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 1/26

10:59 am-8:43 pm

2 stops9h 44m

Lambert-St Louis

Mon 2/2

6:10 am-10:19 am

1 stop4h 09m

$214

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 2/28

6:50 am-10:44 am

1 stop3h 54m

$80

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/28

5:01 pm-9:15 pm

1 stop4h 14m

$80

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/28

Showing 1-10 of 17 results

Compare providers for flights from Des Moines to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to St. Louis

What is the cheapest time of day to fly from DSM to STL?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to St. Louis as you normally would.

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,251 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,251 reviews

Southwest

8.0

Very good

4,251 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

What airports do I use to fly from Des Moines to St. Louis?
Lambert-St Louis is the airport most travelers will use when flying to St. Louis from Des Moines. Booking flights from Des Moines (DSM) to Lambert-St Louis (STL) should be relatively easy as there is 1 daily flight to St. Louis from 1 airline. 1h 05m is how long a flight from Des Moines to Lambert-St Louis will take if you book a nonstop flight.
How popular is this Des Moines to St. Louis flight route?
This flight path from Des Moines to Lambert-St Louis was viewed by 29 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Des Moines to St. Louis?
A quick flight from Des Moines to St. Louis can take about 4h 04m. Delta provides one of the quickest options available for as low as $159. Airlines will cover a distance of 259 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What is the cheapest airline to fly from Des Moines to St. Louis round-trip?
Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $97. Users have found that Southwest is 70% cheaper than the other options available to this destination.
What are the cheapest flights from Des Moines to St. Louis?
While on average a flight from Des Moines to St. Louis is generally $341, our data shows the cheapest flight currently is $128. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $159 for that flight.
Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?
Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.
Can I find deals for business class flights from Des Moines to St. Louis?
Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Collinsville

Eureka

Glencoe

Chesterfield

Alton

Farmington

Festus

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Top airline flying from Des Moines to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$97	Average$254	FlexibilityNo cancel fee	On-time63%

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$71+ Cheap flights from Des Moines to St. Louis (DSM - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. LouisExplore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.

Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.

Find flight deals from Des Moines to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Compare providers for flights from Des Moines to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in December.

Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to St. Louis

What is the cheapest time of day to fly from DSM to STL?

Reviews of airlines servicing St. Louis

See what other customers who have flown with Southwest from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Des Moines to St. Louis?

How popular is this Des Moines to St. Louis flight route?

How long is the flight from Des Moines to St. Louis?

What is the cheapest airline to fly from Des Moines to St. Louis round-trip?

What are the cheapest flights from Des Moines to St. Louis?

Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

How can I find direct flights from Des Moines to St. Louis?

Can I find deals for business class flights from Des Moines to St. Louis?

Traveling to a place near St. Louis?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to St. Louis

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Top airline flying from Des Moines to St. Louis

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Cheapest flights from Des Moines to St. Louis
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.