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$95+ Cheap flights from Des Moines to St. Louis (DSM - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
may. 4 — may. 111
dom. 5/4
dom. 5/11
1 adult, Economy
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Cheap flight deals from Des Moines to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated abril 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$219
(American Airlines)

One-way from

$95
(American Airlines)

Popular in

September

Cheapest in

August

Average price

$309

Good round-trip deal

$368 or less

Good one-way deal

$167 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
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From Des Moines to Lambert-St Louis
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One-way flight from Des Moines to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($45 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($27 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from Des Moines to Lambert-St Louis.
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Price to beat on a one-way flight from Des Moines to Lambert-St Louis.
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Find flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. Louis
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 29, 2025.

This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/226:13 pmDSM - STL
1 stop5h 38mAmerican Airlines
lun. 5/266:00 amSTL - DSM
1 stop5h 13mAmerican Airlines
Deal found 4/29$219
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/66:30 pmDSM - STL
Nonstop1h 05mSouthwest
lun. 6/910:40 pmSTL - DSM
Nonstop1h 10mSouthwest
Deal found 4/29$256
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/221:07 pmDSM - STL
1 stop3h 53mDelta
lun. 5/266:45 amSTL - DSM
2 stops10h 21mDelta
Deal found 4/29$313
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/216:45 pmDSM - STL
1 stop4h 00mUnited Airlines
lun. 6/238:10 amSTL - DSM
1 stop6h 26mUnited Airlines
Deal found 4/29$345

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 29, 2025.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Des Moines

Fly to

St. Louis

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

jue. 5/22

6:13 pm-11:51 pm

1 stop5h 38m

Lambert-St Louis

lun. 5/26

6:00 am-11:13 am

1 stop5h 13m

$219

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

vie. 6/6

6:30 pm-7:35 pm

Nonstop1h 05m

Lambert-St Louis

lun. 6/9

10:40 pm-11:50 pm

Nonstop1h 10m

$256

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

jue. 5/22

1:07 pm-5:00 pm

1 stop3h 53m

Lambert-St Louis

lun. 5/26

6:45 am-5:06 pm

2 stops10h 21m

$313

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

sáb. 6/21

6:45 pm-10:45 pm

1 stop4h 00m

Lambert-St Louis

lun. 6/23

8:10 am-2:36 pm

1 stop6h 26m

$345

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

jue. 5/29

1:12 pm-6:21 pm

1 stop5h 09m

$95

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

mar. 6/3

5:40 am-6:45 am

Nonstop1h 05m

$106

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

vie. 5/30

8:20 pm-10:09 am

1 stop13h 49m

$108

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

mié. 6/11

11:24 am-6:44 pm

1 stop7h 20m

$111

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

jue. 5/29

7:15 pm-11:45 am

3 stops40h 30m

$204

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

lun. 7/7

5:12 pm-12:27 pm

2 stops19h 15m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Compare providers for flights from Des Moines to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to St. Louis

What is the cheapest month to book a flight from Des Moines to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Des Moines to St. Louis (average of $311). Flying from Des Moines to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to STL?

Find hourly flight availability from Des Moines to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated abril 29, 2025.

One of the essential ways to save on airfare from Des Moines to St. Louis is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 3% on airfare.

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated abril 29, 2025.
Southwest
8.0
Very good
4,295 reviews

Overall

8.0

Crew

8.6

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,295 reviews
Southwest
8.0
Very good
4,295 reviews

Overall

8.0

Crew

8.6

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,936 reviews
Southwest
8.0
Very good
4,295 reviews

Overall

8.0

Crew

8.6

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,295 reviews

Overall

8.0

Crew

8.6

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,295 reviews

Overall

8.0

Crew

8.6

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Frontier
6.0
Okay
3,287 reviews
Southwest
8.0
Very good
4,295 reviews

Overall

8.0

Crew

8.6

Food

7.1

Boarding

8.2

Comfort

8.0

Entertainment

7.6

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Des Moines to St. Louis?

    Lambert-St Louis is the airport most travelers will use when flying to St. Louis from Des Moines. Booking flights from Des Moines (DSM) to Lambert-St Louis (STL) should be relatively easy as there is 1 daily flight to St. Louis from 2 different airlines. 1h 05m is how long a flight from Des Moines to Lambert-St Louis will take if you book a nonstop flight.

  • How popular is this Des Moines to St. Louis flight route?

    This flight path from Des Moines to Lambert-St Louis was viewed by 23 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines flying from Des Moines to St. Louis round-trip?

    Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $219. Other airlines that can offer you cheap pricing are Southwest, from $260, and United Airlines, from $266. Users have found that American Airlines is 40% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Des Moines to St. Louis one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $95. Southwest flights start at $106 while deals on Frontier start at $108 one-way.

  • What are the cheapest flights from Des Moines to St. Louis?

    While on average a flight from Des Moines to St. Louis is generally $310, our data shows the cheapest flight currently is $134. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $221 for that flight.

  • Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

    Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.

  • Can I find deals for business class flights from Des Moines to St. Louis?

    Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to St. Louis (average of $311). Flying from Des Moines to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Fenton
Maryland Heights
Fairview Heights
Collinsville
Wentzville
Eureka
St. Peters
Festus
Glencoe
Alton
Farmington
O'Fallon

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Top 2 airlines flying from Des Moines to St. Louis

Discover the top 2 airlines that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$117Average$310FlexibilityNo cancel feeOn-time63%
DeltaCheapest$155Average$470FlexibilityNo cancel feeOn-timeN/A

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