HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Dakota

$216+ Cheap flights from Mississippi to South Dakota

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/21. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FSD
Sep 8 — Sep 151
Mon 9/8
Mon 9/15
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mississippi to South Dakota with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Mississippi to South Dakota

Keep the following information in mind while searching for Mississippi to South Dakota flight deals. Data was last updated September 3, 2025.

Round-trip from

$259
(American Airlines)

One-way from

$216
(American Airlines)
From Mississippi to South Dakota
Search Deals
One-way flight from Mississippi to South Dakota
Search Deals

Find flight deals from Mississippi to South Dakota

Cheapest flights from Mississippi to South Dakota
Explore the most affordable flight options available from Mississippi to South Dakota. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2025.

This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/308:56 amMEM - RAP
1 stop4h 41mUnited Airlines
Tue 10/73:20 pmRAP - MEM
1 stop4h 56mUnited Airlines
Deal found 9/2$259
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/192:15 pmBTR - FSD
1 stop6h 55mAmerican Airlines
Sun 11/231:16 pmFSD - BTR
1 stop6h 10mAmerican Airlines
Deal found 9/3$259
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/263:25 pmMEM - FSD
1 stop4h 56mUnited Airlines
Mon 9/293:12 pmFSD - MEM
1 stop6h 36mUnited Airlines
Deal found 9/2$274
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/175:52 pmMEM - FSD
1 stop5h 10mDelta
Sun 9/215:30 amFSD - MEM
1 stop4h 48mDelta
Deal found 9/2$279
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:41 pmMEM - RAP
1 stop4h 58mDelta
Sat 11/152:51 pmRAP - MEM
1 stop6h 42mDelta
Deal found 9/1$279
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/175:30 amBTR - FSD
1 stop7h 08mAmerican Airlines
Sat 9/205:33 pmFSD - BTR
1 stop5h 38mAmerican Airlines
Deal found 9/3$289
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:36 pmMEM - RAP
1 stop5h 00mDelta
Fri 10/244:34 pmRAP - MEM
1 stop4h 22mDelta
Deal found 9/2$290
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/185:52 pmMEM - FSD
1 stop5h 10mDelta
Sun 9/215:30 amFSD - MEM
1 stop7h 44mDelta
Deal found 9/1$304
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/142:15 pmBTR - FSD
1 stop6h 55mAmerican Airlines
Wed 11/195:30 amFSD - BTR
2 stops8h 20mAmerican Airlines
Deal found 9/3$309
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/53:25 pmMEM - RAP
1 stop6h 09mUnited Airlines
Tue 10/73:20 pmRAP - MEM
1 stop4h 56mUnited Airlines
Deal found 8/31$321
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/59:37 amMEM - FSD
1 stop7h 26mAmerican Airlines
Mon 9/85:19 pmFSD - MEM
1 stop5h 38mAmerican Airlines
Deal found 9/1$333
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/512:20 pmMEM - FSD
1 stop5h 04mDelta
Mon 9/812:56 pmFSD - MEM
2 stops10h 08mDelta
Deal found 9/1$338

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to South Dakota that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 3, 2025.
Use the filters below to find and compare flights from Mississippi to South Dakota that are best for you.

Fly from

Mississippi

Fly to

South Dakota

Route

Depart

Return

Price

MemphisSioux Falls

MEM - FSD

MEMFSD

Memphis

Sat 2/21

6:00 am-12:35 pm

1 stop6h 35m

Sioux Falls Joe Foss Field

Tue 2/24

5:15 am-11:23 am

1 stop6h 08m

$249

MemphisRapid City

MEM - RAP

MEMRAP

Memphis

Tue 9/30

8:56 am-12:37 pm

1 stop4h 41m

Rapid City

Tue 10/7

3:20 pm-9:16 pm

1 stop4h 56m

$259

Baton RougeSioux Falls

BTR - FSD

BTRFSD

Baton Rouge Ryan

Wed 11/19

2:15 pm-9:10 pm

1 stop6h 55m

Sioux Falls Joe Foss Field

Sun 11/23

1:16 pm-7:26 pm

1 stop6h 10m

$259

MemphisSioux Falls

MEM - FSD

MEMFSD

Memphis

Fri 9/26

3:25 pm-8:21 pm

1 stop4h 56m

Sioux Falls Joe Foss Field

Mon 9/29

3:12 pm-9:48 pm

1 stop6h 36m

$274

MemphisSioux Falls

MEM - FSD

MEMFSD

Memphis

Wed 9/17

5:52 pm-11:02 pm

1 stop5h 10m

Sioux Falls Joe Foss Field

Sun 9/21

5:30 am-10:18 am

1 stop4h 48m

$279

MemphisRapid City

MEM - RAP

MEMRAP

Memphis

Thu 11/13

6:41 pm-10:39 pm

1 stop4h 58m

Rapid City

Sat 11/15

2:51 pm-10:33 pm

1 stop6h 42m

$279

Baton RougeSioux Falls

BTR - FSD

BTRFSD

Baton Rouge Ryan

Wed 9/17

5:30 am-12:38 pm

1 stop7h 08m

Sioux Falls Joe Foss Field

Sat 9/20

5:33 pm-11:11 pm

1 stop5h 38m

$289

MemphisRapid City

MEM - RAP

MEMRAP

Memphis

Fri 10/17

6:36 pm-10:36 pm

1 stop5h 00m

Rapid City

Fri 10/24

4:34 pm-9:56 pm

1 stop4h 22m

$290

MemphisSioux Falls

MEM - FSD

MEMFSD

Memphis

Thu 9/18

5:52 pm-11:02 pm

1 stop5h 10m

Sioux Falls Joe Foss Field

Sun 9/21

5:30 am-1:14 pm

1 stop7h 44m

$304

Baton RougeSioux Falls

BTR - FSD

BTRFSD

Baton Rouge Ryan

Fri 11/14

2:15 pm-9:10 pm

1 stop6h 55m

Sioux Falls Joe Foss Field

Wed 11/19

10:59 am-8:50 pm

2 stops9h 51m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/2

Showing 1-10 of 42 results
1
2
3
...
5

Best time to book a flight from Mississippi to South Dakota

Have a flexible travel schedule? Discover the best time to fly to South Dakota from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South Dakota
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Dakota

Get insights into the airlines that provide service to South Dakota. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Dakota. Reviews last updated September 3, 2025.
Get a feel of what it's like to fly with American Airlines from Mississippi to South Dakota by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Crew

8.0

Boarding

7.5

Food

6.5

Overall

7.2

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

BNA - ORD

My flight was 8 hours delayed, so I missed my connecting flight to Dublin. I understand it’s not the staff’s fault but the lack of sympathy and apology was appalling. I had been sat in the airport since 4am until 3pm and they did not seem understanding. Not good. Need better customer service.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Entertainment

6.9

Crew

8.0

Boarding

7.5

Food

6.5

Overall

7.2

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

BNA - ORD

My flight was 8 hours delayed, so I missed my connecting flight to Dublin. I understand it’s not the staff’s fault but the lack of sympathy and apology was appalling. I had been sat in the airport since 4am until 3pm and they did not seem understanding. Not good. Need better customer service.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South Dakota. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mississippi to South Dakota?

    Departing from Mississippi to South Dakota will take you 4h 41m. Airlines will cover a distance of 931 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Mississippi to South Dakota that include hotel bookings?

    Yes. In addition to deals on Mississippi to South Dakota flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to South Dakota?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South Dakota.

  • Can I find deals for business class flights from Mississippi to South Dakota?

    Yes. Cheapflights offers flight deals from Mississippi to South Dakota by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to South Dakota?

    Currently, September is the cheapest month in which you can book a flight from Mississippi to South Dakota (average of $334). Flying from Mississippi to South Dakota in December is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to South Dakota

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to John F Kennedy Intl flights
Los Angeles to Newark flights
Dallas/Fort Worth to John F Kennedy Intl flights
John F Kennedy Intl to Los Angeles flights
Dallas/Fort Worth to LaGuardia flights
Dallas/Fort Worth to Las Vegas flights
John F Kennedy Intl to O'Hare Intl flights
Seattle to Las Vegas flights
John F Kennedy Intl to Miami flights
Newark to Los Angeles flights
LaGuardia to O'Hare Intl flights
Newark to Fort Lauderdale flights
San Francisco to John F Kennedy Intl flights
Newark to Miami flights
John F Kennedy Intl to Las Vegas flights
Los Angeles to Seattle flights
John F Kennedy Intl to Dallas/Fort Worth flights
Dallas/Fort Worth to Seattle flights
Newark to Las Vegas flights
O'Hare Intl to LaGuardia flights
O'Hare Intl to John F Kennedy Intl flights
Dallas/Fort Worth to O'Hare Intl flights
LaGuardia to Dallas/Fort Worth flights
O'Hare Intl to Las Vegas flights
LaGuardia to Fort Lauderdale flights
Newark to O'Hare Intl flights
San Francisco to Newark flights
Dallas/Fort Worth to Newark flights
LaGuardia to Miami flights
O'Hare Intl to Dallas/Fort Worth flights
Los Angeles to Dallas/Fort Worth flights
Seattle to Los Angeles flights
Seattle to Dallas/Fort Worth flights
John F Kennedy Intl to Fort Lauderdale flights
John F Kennedy Intl to Orlando flights
Dallas/Fort Worth to Denver flights
Los Angeles to LaGuardia flights
Dulles Intl to Dallas/Fort Worth flights
John F Kennedy Intl to San Francisco flights
Los Angeles to Honolulu flights
Newark to Dallas/Fort Worth flights
O'Hare Intl to Newark flights
Dallas/Fort Worth to Los Angeles flights
Los Angeles to O'Hare Intl flights
Ontario to John F Kennedy Intl flights
Ontario to Seattle flights
Newark to Orlando flights
Newark to San Francisco flights
Hobby to Newark flights
Atlanta to LaGuardia flights

Top airline flying from Mississippi to South Dakota

Discover the top airline that operate flights from Mississippi to South Dakota. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$288Average$764FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.