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South Carolina

$145+ Cheap flights from Panama City, FL (ECP) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — CHS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Delta deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:05 am
ECP
-
MYR
1 stop5h 26m
Delta
Mon 3/236:54 pm
MYR
-
ECP
1 stop5h 10m
Delta
Deal found 1/28$318
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:10 pm
ECP
-
CHS
1 stop3h 45m
Delta
Tue 5/52:21 pm
CHS
-
ECP
1 stop6h 15m
Delta
Deal found 1/27$335
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:19 am
ECP
-
CHS
1 stop5h 34m
American Airlines
Sat 3/218:17 pm
CHS
-
ECP
1 stop4h 32m
American Airlines
Deal found 1/27$354
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:49 am
ECP
-
CHS
1 stop4h 31m
Delta
Sat 5/95:30 am
CHS
-
ECP
1 stop3h 47m
Delta
Deal found 1/27$355
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:43 pm
ECP
-
MYR
1 stop4h 21m
Delta
Sun 4/126:54 pm
MYR
-
ECP
1 stop5h 10m
Delta
Deal found 1/27$367
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/304:40 pm
ECP
-
CHS
1 stop6h 19m
American Airlines
Fri 5/88:21 pm
CHS
-
ECP
1 stop4h 25m
American Airlines
Deal found 1/27$374
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:31 pm
ECP
-
CHS
1 stop4h 24m
Delta
Sun 5/107:59 pm
CHS
-
ECP
1 stop3h 47m
Delta
Deal found 1/27$375
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:00 am
ECP
-
CHS
2 stops11h 03m
American Airlines
Tue 6/98:33 pm
CHS
-
ECP
1 stop4h 08m
American Airlines
Deal found 1/27$380
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:49 am
ECP
-
CHS
2 stops11h 20m
Delta
Thu 5/75:30 am
CHS
-
ECP
1 stop3h 47m
Delta
Deal found 1/27$385
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:55 am
ECP
-
CHS
2 stops8h 10m
Southwest
Tue 6/96:35 am
CHS
-
ECP
2 stops11h 10m
Southwest
Deal found 1/27$391
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/194:34 pm
ECP
-
CHS
1 stop5h 27m
American Airlines
Sun 2/225:10 am
CHS
-
ECP
1 stop5h 56m
American Airlines
Deal found 1/28$394
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:30 pm
ECP
-
CHS
1 stop4h 26m
Delta
Sun 6/77:59 pm
CHS
-
ECP
1 stop3h 47m
Delta
Deal found 1/27$395

Find flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$318
(Delta)

One-way from

$145
(Delta)

Popular in

November

Cheapest in

October
Provider with most accurate pricing for Panama City NW Florida Beaches-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Myrtle Beach Intl flights.
Search Deals
From Panama City NW Florida Beaches to South Carolina
Search Deals
One-way flight from Panama City NW Florida Beaches to South Carolina
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($113 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 11% potential price decrease ($45 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Panama City

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Thu 3/19

7:05 am-1:31 pm

1 stop5h 26m

Myrtle Beach Intl

Mon 3/23

6:54 pm-11:04 pm

1 stop5h 10m

$318

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Tue 6/2

5:30 pm-11:56 pm

1 stop5h 26m

Charleston

Wed 6/10

10:30 am-12:38 pm

1 stop3h 08m

$335

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Mon 3/16

7:19 am-1:53 pm

1 stop5h 34m

Charleston

Sat 3/21

8:17 pm-11:49 pm

1 stop4h 32m

$354

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Sat 6/6

6:00 am-11:24 am

1 stop4h 24m

Charleston

Wed 6/10

7:30 am-10:14 am

1 stop3h 44m

$355

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Sun 6/7

7:05 pm-11:57 pm

1 stop3h 52m

Charleston

Tue 6/9

6:30 am-10:14 am

1 stop4h 44m

$355

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 6/4

4:10 pm-9:44 pm

1 stop4h 34m

Charleston

Tue 6/9

10:30 am-12:38 pm

1 stop3h 08m

$355

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 4/30

4:31 pm-9:55 pm

1 stop4h 24m

Charleston

Wed 5/6

4:35 pm-7:36 pm

1 stop4h 01m

$355

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Wed 4/29

5:49 am-11:20 am

1 stop4h 31m

Charleston

Thu 5/7

5:30 am-8:17 am

1 stop3h 47m

$355

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Tue 4/28

5:49 am-11:20 am

1 stop4h 31m

Charleston

Sat 5/9

5:30 am-8:17 am

1 stop3h 47m

$355

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 4/23

5:49 am-10:09 am

1 stop3h 20m

Charleston

Sun 4/26

5:20 am-8:35 am

1 stop4h 15m

$355

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 33 results
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City, Florida to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to South Carolina (average of $96). Flying from Panama City, Florida to South Carolina in April is currently the most expensive (average of $239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SC?

Find hourly flight availability from Panama City to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

It’s optimal to fly from Panama City, Florida to South Carolina at noon. By choosing this option you can save up to 20% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 29, 2026.
See what other customers who have flown with Delta from Panama City to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    For a flight from Panama City to South Carolina, you will be flying from NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How long is the flight from Panama City, Florida to South Carolina?

    Airlines like Delta, American Airlines, and Southwest fly from Panama City, Florida to South Carolina in about 5h 26m. The time it takes to get you to your destination can typically vary by up to 7h 39m. Airlines will cover a distance of 463 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Panama City, Florida to South Carolina?

    Most travelers choose Panama City NW Florida Beaches - Charleston, Panama City NW Florida Beaches - Greenville or Panama City NW Florida Beaches - Myrtle Beach Intl when deciding on the best route from Panama City, Florida to South Carolina.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to South Carolina (average of $96). Flying from Panama City, Florida to South Carolina in April is currently the most expensive (average of $239). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama City to South Carolina

Discover the top airline that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$138Average$367FlexibilityNo cancel feeOn-timeN/A

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