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South Carolina

$255+ Cheap flights from Panama City, FL (ECP) to South Carolina

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$255
(Delta)

Popular in

March

Cheapest in

October

Average price

$256
Provider with most accurate pricing for Panama City NW Florida Beaches-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Myrtle Beach Intl flights.
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From Panama City NW Florida Beaches to South Carolina
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Highest demand for flights based on searches. 16% potential increase in price ($76 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($30 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:20 pmECP - CHS
1 stop5h 19mDelta
Sun 12/285:25 amCHS - ECP
1 stop4h 12mDelta
Deal found 10/28$318
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:15 amECP - CHS
2 stops15h 39mAmerican Airlines
Sun 12/288:08 pmCHS - ECP
1 stop4h 45mAmerican Airlines
Deal found 10/28$405
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:00 pmECP - CHS
1 stop3h 44mAmerican Airlines
Sun 11/165:10 amCHS - ECP
1 stop6h 23mAmerican Airlines
Deal found 10/28$411
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:21 amECP - GSP
1 stop3h 59mAmerican Airlines
Sun 11/166:45 amGSP - ECP
1 stop4h 48mAmerican Airlines
Deal found 10/28$419
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:15 amECP - CHS
2 stops8h 50mSouthwest
Sun 12/285:10 amCHS - ECP
2 stops8h 00mSouthwest
Deal found 10/28$542
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:00 pmECP - GSP
1 stop4h 18mDelta
Sun 11/25:35 amGSP - ECP
1 stop4h 44mDelta
Deal found 10/27$575
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/35:55 pmECP - MYR
1 stop3h 41mAmerican Airlines
Fri 11/77:41 pmMYR - ECP
1 stop4h 34mAmerican Airlines
Deal found 10/27$577
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/318:00 amECP - GSP
1 stop6h 55mSouthwest
Sun 11/28:00 amGSP - ECP
2 stops14h 05mSouthwest
Deal found 10/27$602
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/37:15 amECP - MYR
1 stop6h 00mSouthwest
Fri 11/712:40 pmMYR - ECP
2 stops9h 25mSouthwest
Deal found 10/27$622
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:41 pmECP - GSP
1 stop3h 43mAmerican Airlines
Sun 11/26:40 pmGSP - ECP
1 stop6h 09mAmerican Airlines
Deal found 10/27$628
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/285:00 pmECP - CHS
1 stop5h 59mDelta
Tue 11/48:10 amCHS - ECP
1 stop5h 30mDelta
Deal found 10/28$637
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/283:41 pmECP - CHS
2 stops7h 18mAmerican Airlines
Tue 11/48:00 amCHS - ECP
1 stop4h 29mAmerican Airlines
Deal found 10/28$642

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Panama City

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 1/15

1:32 pm-6:55 pm

1 stop4h 23m

Greenville

Sun 1/18

5:40 am-9:14 am

1 stop4h 34m

$255

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Tue 4/14

11:15 am-3:39 pm

1 stop3h 24m

Charleston

Wed 4/15

5:30 am-8:17 am

1 stop3h 47m

$317

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Wed 12/24

2:20 pm-8:39 pm

1 stop5h 19m

Charleston

Sun 12/28

5:25 am-8:37 am

1 stop4h 12m

$318

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Thu 1/15

7:35 am-8:20 pm

2 stops11h 45m

Greenville

Sun 1/18

11:15 am-6:10 pm

1 stop7h 55m

$332

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Tue 3/24

7:45 am-1:29 pm

1 stop4h 44m

Myrtle Beach Intl

Sat 3/28

6:45 pm-10:42 pm

1 stop4h 57m

$337

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Wed 12/24

7:15 am-11:54 pm

2 stops15h 39m

Charleston

Sun 12/28

8:08 pm-11:53 pm

1 stop4h 45m

$405

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Wed 11/12

12:00 pm-4:44 pm

1 stop3h 44m

Charleston

Sun 11/16

5:10 am-10:33 am

1 stop6h 23m

$411

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 11/12

8:21 am-1:20 pm

1 stop3h 59m

Greenville

Sun 11/16

6:45 am-10:33 am

1 stop4h 48m

$419

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Tue 4/14

2:53 pm-7:03 pm

1 stop3h 10m

Charleston

Wed 4/15

7:40 am-3:17 pm

2 stops8h 37m

$441

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 3/24

9:23 am-10:18 pm

2 stops11h 55m

Greenville

Sat 3/28

5:45 am-8:20 am

1 stop3h 35m

$502

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 13 results
1
2

Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City, Florida to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to South Carolina (average of $96). Flying from Panama City, Florida to South Carolina in January is currently the most expensive (average of $280). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SC?

Find hourly flight availability from Panama City to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

It’s optimal to fly from Panama City, Florida to South Carolina in the afternoon. By choosing this option you can save up to 46% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Panama City, Florida to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Panama City to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Panama City, Florida to South Carolina flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2025.
See what other customers who have flown with Delta from Panama City to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Entertainment

7.9

Comfort

7.9

Overall

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Entertainment

7.9

Comfort

7.9

Overall

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    For a flight from Panama City to South Carolina, you will be flying from NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How long is the flight from Panama City, Florida to South Carolina?

    Airlines like Delta, Southwest, and American Airlines fly from Panama City, Florida to South Carolina in about 4h 23m. The time it takes to get you to your destination can typically vary by up to 11h 16m. Airlines will cover a distance of 376 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Panama City, Florida to South Carolina?

    Most travelers choose Panama City NW Florida Beaches - Charleston, Panama City NW Florida Beaches - Greenville or Panama City NW Florida Beaches - Myrtle Beach Intl when deciding on the best route from Panama City, Florida to South Carolina.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Panama City, Florida to South Carolina (average of $96). Flying from Panama City, Florida to South Carolina in January is currently the most expensive (average of $280). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama City to South Carolina

Discover the top airline that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$391FlexibilityNo cancel feeOn-timeN/A

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