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South Carolina

$99+ Cheap flights from Panama City, FL (ECP) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — CHS
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated July 29, 2025.

Round-trip from

$197
(Delta)

One-way from

$99
(Delta)

Popular in

March

Cheapest in

September

Average price

$597
From Panama City NW Florida Beaches to South Carolina
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One-way flight from Panama City NW Florida Beaches to South Carolina
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Highest demand for flights based on searches. 15% potential increase in price ($70 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/275:02 pmECP - GSP
1 stop5h 32mDelta
Tue 9/306:35 amGSP - ECP
1 stop4h 20mDelta
Deal found 7/29$197
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/306:59 pmECP - CHS
1 stop3h 52mDelta
Sun 8/315:15 amCHS - ECP
1 stop5h 40mDelta
Deal found 7/28$217
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:54 pmECP - MYR
1 stop3h 55mDelta
Mon 10/66:58 pmMYR - ECP
1 stop5h 12mDelta
Deal found 7/29$241
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/302:36 pmECP - CHS
2 stops8h 23mAmerican Airlines
Sun 8/316:00 amCHS - ECP
1 stop4h 38mAmerican Airlines
Deal found 7/28$263
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3111:58 amECP - GSP
1 stop5h 39mAmerican Airlines
Sun 11/27:45 amGSP - ECP
1 stop3h 48mAmerican Airlines
Deal found 7/29$303
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/32:55 pmECP - MYR
1 stop6h 25mSouthwest
Mon 10/66:55 amMYR - ECP
2 stops12h 40mSouthwest
Deal found 7/29$304
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/95:30 amECP - MYR
1 stop3h 56mAmerican Airlines
Sun 10/128:20 pmMYR - ECP
1 stop4h 24mAmerican Airlines
Deal found 7/27$307
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/127:25 amECP - GSP
2 stops12h 35mSouthwest
Sun 9/147:15 amGSP - ECP
2 stops9h 35mSouthwest
Deal found 7/28$359
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/308:05 amECP - CHS
2 stops7h 35mSouthwest
Sun 8/318:35 amCHS - ECP
2 stops9h 20mSouthwest
Deal found 7/28$421
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/265:06 pmECP - GSP
1 stop27h 54mUnited Airlines
Tue 9/210:15 amGSP - ECP
2 stops27h 48mUnited Airlines
Deal found 7/27$544
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/45:02 pmECP - CHS
2 stops16h 12mUnited Airlines
Wed 8/66:10 amCHS - ECP
3 stops16h 50mUnited Airlines
Deal found 7/29$1,159

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Panama City

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Sat 9/27

5:02 pm-11:34 pm

1 stop5h 32m

Greenville

Tue 9/30

6:35 am-9:55 am

1 stop4h 20m

$197

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Sat 8/30

6:59 pm-11:51 pm

1 stop3h 52m

Charleston

Sun 8/31

5:15 am-9:55 am

1 stop5h 40m

$217

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Fri 10/3

6:54 pm-11:49 pm

1 stop3h 55m

Myrtle Beach Intl

Mon 10/6

6:58 pm-11:10 pm

1 stop5h 12m

$241

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Sat 8/30

2:36 pm-11:59 pm

2 stops8h 23m

Charleston

Sun 8/31

6:00 am-9:38 am

1 stop4h 38m

$263

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 10/31

11:58 am-6:37 pm

1 stop5h 39m

Greenville

Sun 11/2

7:45 am-10:33 am

1 stop3h 48m

$303

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Fri 10/3

2:55 pm-10:20 pm

1 stop6h 25m

Myrtle Beach Intl

Mon 10/6

6:55 am-6:35 pm

2 stops12h 40m

$304

Panama CityMyrtle Beach

ECP - MYR

ECPMYR

Panama City NW Florida Beaches

Thu 10/9

5:30 am-10:26 am

1 stop3h 56m

Myrtle Beach Intl

Sun 10/12

8:20 pm-11:44 pm

1 stop4h 24m

$307

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Fri 9/12

7:25 am-9:00 pm

2 stops12h 35m

Greenville

Sun 9/14

7:15 am-3:50 pm

2 stops9h 35m

$359

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Sat 8/30

8:05 am-4:40 pm

2 stops7h 35m

Charleston

Sun 8/31

8:35 am-4:55 pm

2 stops9h 20m

$421

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 8/26

5:06 pm-10:00 pm

1 stop27h 54m

Greenville

Tue 9/2

10:15 am-1:03 pm

2 stops27h 48m

$544

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/26

Showing 1-10 of 17 results
1
2

Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City, Florida to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to South Carolina (average of $217). Flying from Panama City, Florida to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SC?

Find hourly flight availability from Panama City to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 29, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Panama City to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,977 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,899 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    For a flight from Panama City to South Carolina, you will be flying from NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • What are the cheapest airlines to fly from Panama City, Florida to South Carolina one-way?

    The cheapest airlines for a one-way flight from Panama City, Florida to South Carolina are Delta ($99), American Airlines ($154), and Southwest ($179).

  • What are the most popular routes from Panama City, Florida to South Carolina?

    Most travelers choose Panama City NW Florida Beaches - Charleston, Panama City NW Florida Beaches - Greenville or Panama City NW Florida Beaches - Myrtle Beach Intl when deciding on the best route from Panama City, Florida to South Carolina.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to South Carolina (average of $217). Flying from Panama City, Florida to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to South Carolina

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Top 2 airlines flying from Panama City to South Carolina

Discover the top 2 airlines that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$429FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$225Average$346FlexibilityNo cancel feeOn-time71%

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