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South Carolina

$118+ Cheap flights from Panama City, FL (ECP) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — CHS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Panama City to South Carolina

Keep the following information in mind while searching for Panama City to South Carolina flight deals. Data was last updated September 11, 2025.

Round-trip from

$199
(Delta)

One-way from

$118
(Delta)

Popular in

March

Cheapest in

November

Average price

$293
From Panama City NW Florida Beaches to South Carolina
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One-way flight from Panama City NW Florida Beaches to South Carolina
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Highest demand for flights based on searches. 16% potential increase in price ($76 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Panama City to South Carolina

Cheapest flights from Panama City to South Carolina
Explore the most affordable flight options available from Panama City to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amECP - CHS
1 stop3h 20mDelta
Sat 10/186:55 pmCHS - ECP
1 stop4h 46mDelta
Deal found 9/10$199
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/153:41 pmECP - CHS
2 stops7h 18mAmerican Airlines
Sat 10/187:43 pmCHS - ECP
1 stop5h 01mAmerican Airlines
Deal found 9/10$225
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/174:25 pmECP - CHS
1 stop3h 26mDelta
Mon 10/208:03 pmCHS - ECP
1 stop4h 07mDelta
Deal found 9/11$248
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/243:41 pmECP - CHS
1 stop6h 27mAmerican Airlines
Mon 10/276:00 amCHS - ECP
2 stops9h 10mAmerican Airlines
Deal found 9/11$253
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:40 pmECP - CHS
1 stop4h 17mDelta
Sun 11/165:25 amCHS - ECP
1 stop4h 10mDelta
Deal found 9/11$294
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:21 amECP - CHS
2 stops9h 56mAmerican Airlines
Sun 11/166:45 amCHS - ECP
1 stop4h 48mAmerican Airlines
Deal found 9/11$299
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/237:00 amECP - GSP
1 stop5h 28mDelta
Tue 10/710:04 amGSP - ECP
1 stop3h 36mDelta
Deal found 9/9$300
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:35 pmECP - CHS
1 stop4h 20mSouthwest
Sun 11/166:15 amCHS - ECP
1 stop3h 50mSouthwest
Deal found 9/8$305
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:41 pmECP - GSP
1 stop6h 10mAmerican Airlines
Sun 11/27:45 amGSP - ECP
1 stop3h 48mAmerican Airlines
Deal found 9/11$343
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:55 pmECP - GSP
1 stop4h 16mAmerican Airlines
Mon 12/16:40 pmGSP - ECP
1 stop6h 09mAmerican Airlines
Deal found 9/10$347
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/237:00 amECP - GSP
2 stops10h 05mSouthwest
Tue 10/710:40 amGSP - ECP
1 stop4h 50mSouthwest
Deal found 9/9$354
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/252:37 pmECP - GSP
1 stop3h 44mAmerican Airlines
Mon 12/16:40 pmGSP - ECP
1 stop6h 09mAmerican Airlines
Deal found 9/10$377

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Panama City to South Carolina that are best for you.

Fly from

Panama City

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Wed 10/15

6:00 am-10:20 am

1 stop3h 20m

Charleston

Sat 10/18

6:55 pm-10:41 pm

1 stop4h 46m

$199

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Wed 10/15

3:41 pm-11:59 pm

2 stops7h 18m

Charleston

Sat 10/18

7:43 pm-11:44 pm

1 stop5h 01m

$225

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Fri 10/24

3:41 pm-8:43 pm

1 stop4h 02m

Charleston

Mon 10/27

6:00 am-10:13 am

1 stop5h 13m

$248

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Fri 10/17

4:25 pm-8:51 pm

1 stop3h 26m

Charleston

Mon 10/20

8:03 pm-11:10 pm

1 stop4h 07m

$248

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Fri 11/14

6:40 pm-11:57 pm

1 stop4h 17m

Charleston

Sun 11/16

5:25 am-8:35 am

1 stop4h 10m

$294

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Mon 3/2

4:10 pm-9:22 pm

1 stop4h 12m

Greenville

Mon 3/16

7:55 pm-10:42 pm

1 stop3h 47m

$295

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Fri 11/14

8:21 am-7:17 pm

2 stops9h 56m

Charleston

Sun 11/16

6:45 am-10:33 am

1 stop4h 48m

$299

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Tue 9/23

7:00 am-1:28 pm

1 stop5h 28m

Greenville

Tue 10/7

10:04 am-12:40 pm

1 stop3h 36m

$300

Panama CityGreenville

ECP - GSP

ECPGSP

Panama City NW Florida Beaches

Wed 9/24

4:46 pm-9:07 pm

1 stop3h 21m

Greenville

Wed 10/1

5:30 am-8:08 am

1 stop3h 38m

$300

Panama CityCharleston

ECP - CHS

ECPCHS

Panama City NW Florida Beaches

Thu 11/13

5:35 pm-10:55 pm

1 stop4h 20m

Charleston

Sun 11/16

6:15 am-9:05 am

1 stop3h 50m

$305

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 24 results
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2
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Best time to book a flight from Panama City to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South Carolina

What is the cheapest month to book a flight from Panama City, Florida to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to South Carolina (average of $217). Flying from Panama City, Florida to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SC?

Find hourly flight availability from Panama City to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City, Florida to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 11, 2025.
See what other customers who have flown with Delta from Panama City to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Boarding

8.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South Carolina?

    For a flight from Panama City to South Carolina, you will be flying from NW Florida Beaches. Panama City NW Florida Beaches (ECP) is just 16.0 mi from the center of the city.

  • How long is the flight from Panama City, Florida to South Carolina?

    Airlines like Delta, American Airlines, and Southwest fly from Panama City, Florida to South Carolina in about 3h 20m. The time it takes to get you to your destination can typically vary by up to 3h 58m. Airlines will cover a distance of 381 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City, Florida to South Carolina one-way?

    The cheapest airlines for a one-way flight from Panama City, Florida to South Carolina are Delta ($118), American Airlines ($243), and Southwest ($364).

  • What are the most popular routes from Panama City, Florida to South Carolina?

    Most travelers choose Panama City NW Florida Beaches - Charleston, Panama City NW Florida Beaches - Myrtle Beach Intl or Panama City NW Florida Beaches - Greenville when deciding on the best route from Panama City, Florida to South Carolina.

  • Can I find deals for flights from Panama City to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama City to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South Carolina.

  • Can I find deals for business class flights from Panama City to South Carolina?

    Yes. Cheapflights offers flight deals from Panama City to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to South Carolina (average of $217). Flying from Panama City, Florida to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to South Carolina

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Top airline flying from Panama City to South Carolina

Discover the top airline that operate flights from Panama City to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$202Average$388FlexibilityNo cancel feeOn-timeN/A

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