HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$81+ Cheap flights from Harrisburg (MDT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/7. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — CHS
feb. 7 — feb. 141
sáb. 2/7
sáb. 2/14
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Harrisburg to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Harrisburg to South Carolina

Keep the following information in mind while searching for Harrisburg to South Carolina flight deals. Data was last updated enero 8, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$140
(Booking.com)

One-way from

$81
(Frontier)

Popular in

December

Cheapest in

July

Average price

$281
Provider with most accurate pricing for Harrisburg-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Myrtle Beach Intl flights.
Search Deals
From Harrisburg to South Carolina
Search Deals
One-way flight from Harrisburg to South Carolina
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($100 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Find flight deals from Harrisburg to South Carolina

Cheapest flights from Harrisburg to South Carolina
Explore the most affordable flight options available from Harrisburg to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 8, 2026.

This Booking.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/1412:10 pmMDT - MYR
Nonstop1h 28mAllegiant Air
jue. 5/216:15 pmMYR - MDT
Nonstop1h 32mAllegiant Air
Deal found 1/8$140
This Booking.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/123:40 pmMDT - MYR
Nonstop1h 28mAllegiant Air
jue. 4/162:03 pmMYR - MDT
Nonstop1h 38mAllegiant Air
Deal found 1/8$156
This Kiwi.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/54:38 pmMDT - MYR
Nonstop1h 28mAllegiant Air
jue. 4/91:58 pmMYR - MDT
Nonstop1h 38mAllegiant Air
Deal found 1/6$176
This Mytrip deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/133:08 pmMDT - MYR
Nonstop1h 36mAllegiant Air
sáb. 6/205:34 pmMYR - MDT
Nonstop1h 34mAllegiant Air
Deal found 1/7$178
This Kiwi.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/74:00 pmMDT - MYR
Nonstop1h 36mAllegiant Air
sáb. 6/135:34 pmMYR - MDT
Nonstop1h 34mAllegiant Air
Deal found 1/8$180
This Booking.com deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/54:38 pmMDT - MYR
Nonstop1h 28mAllegiant Air
dom. 4/125:58 pmMYR - MDT
Nonstop1h 38mAllegiant Air
Deal found 1/6$185
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/284:00 pmMDT - MYR
Nonstop1h 36mAllegiant Air
sáb. 7/45:35 pmMYR - MDT
Nonstop1h 34mAllegiant Air
Deal found 1/7$191
This United Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/103:10 pmMDT - SAV
1 stop6h 26mUnited Airlines
mié. 2/189:50 amSAV - MDT
1 stop4h 06mUnited Airlines
Deal found 1/7$195
This Kiwi.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/144:00 pmMDT - MYR
Nonstop1h 36mAllegiant Air
sáb. 6/205:34 pmMYR - MDT
Nonstop1h 34mAllegiant Air
Deal found 1/8$198
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/103:08 pmMDT - SAV
2 stops5h 52mAmerican Airlines
mié. 2/186:25 amSAV - MDT
1 stop5h 36mAmerican Airlines
Deal found 1/7$200
This Kiwi.com deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/273:08 pmMDT - MYR
Nonstop1h 36mAllegiant Air
sáb. 7/45:35 pmMYR - MDT
Nonstop1h 34mAllegiant Air
Deal found 1/7$205
This Kiwi.com deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/87:50 pmMDT - CLT
1 stop23h 05mFrontier
sáb. 2/144:49 pmCLT - MDT
1 stop17h 02mFrontier
Deal found 1/8$209

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 8, 2026.
Use the filters below to find and compare flights from Harrisburg to South Carolina that are best for you.

Fly from

Harrisburg

Fly to

South Carolina

Route

Depart

Return

Price

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

mar. 2/10

3:10 pm-9:36 pm

1 stop6h 26m

Savannah/Hilton Head

mié. 2/18

9:50 am-1:56 pm

1 stop4h 06m

$195

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

mar. 2/10

3:08 pm-9:00 pm

2 stops5h 52m

Savannah/Hilton Head

mié. 2/18

6:25 am-12:01 pm

1 stop5h 36m

$200

HarrisburgCharlotte

MDT - CLT

MDTCLT

Harrisburg

mié. 2/4

6:04 pm-7:25 pm

2 stops49h 21m

Charlotte Douglas

mié. 2/11

2:46 pm-6:12 pm

1 stop27h 26m

$232

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

sáb. 2/14

2:59 pm-9:44 pm

2 stops6h 45m

Savannah/Hilton Head

jue. 2/19

9:03 am-2:48 pm

1 stop5h 45m

$237

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

vie. 2/6

6:02 pm-11:41 pm

1 stop5h 39m

Myrtle Beach Intl

vie. 2/13

6:55 pm-11:27 pm

1 stop4h 32m

$249

HarrisburgCharlotte

MDT - CLT

MDTCLT

Harrisburg

sáb. 3/14

10:18 pm-8:03 am

1 stop9h 45m

Charlotte Douglas

mié. 3/18

7:18 pm-9:28 pm

1 stop26h 10m

$249

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

mié. 2/25

6:00 am-12:11 pm

1 stop6h 11m

Myrtle Beach Intl

lun. 3/2

6:00 am-11:10 am

1 stop5h 10m

$249

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

vie. 1/30

3:03 pm-8:59 pm

1 stop5h 56m

Greenville

dom. 2/1

6:00 am-10:54 am

1 stop4h 54m

$249

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

sáb. 1/31

4:49 pm-8:45 pm

1 stop3h 56m

Greenville

mar. 2/3

6:00 am-10:17 am

1 stop4h 17m

$249

HarrisburgColumbia

MDT - CAE

MDTCAE

Harrisburg

mar. 3/10

11:57 am-5:53 pm

1 stop5h 56m

Columbia Metropolitan

mar. 3/17

7:18 am-11:32 am

1 stop4h 14m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/7

Showing 1-10 of 58 results
1
2
3
...
6

Best time to book a flight from Harrisburg to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to South Carolina

What is the cheapest month to book a flight from Harrisburg to South Carolina?

Currently, June is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $98). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated enero 8, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Harrisburg to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,025 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,025 reviews
Delta
7.9
Good
8,025 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,139 reviews
Delta
7.9
Good
8,025 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,094 reviews
Delta
7.9
Good
8,025 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
702 reviews
Delta
7.9
Good
8,025 reviews

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to South Carolina?

    If you book a flight to South Carolina from Harrisburg, you will be flying from Harrisburg, which is the city’s only airport. Harrisburg (MDT) is located 8.5 mi from the center of Harrisburg.

  • How long is the flight from Harrisburg to South Carolina?

    United Airlines, American Airlines, and Delta can get you from Harrisburg to South Carolina in just under 5h 39m. Your travel time can differ by up to 47m. The distance between Harrisburg and South Carolina is about 465 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Harrisburg to South Carolina?

    The most popular flight routes from Harrisburg to South Carolina are Harrisburg - Charlotte Douglas, Harrisburg - Charleston and Harrisburg - Myrtle Beach Intl.

  • Can I find deals for flights from Harrisburg to South Carolina that include hotel bookings?

    Yes. In addition to deals on Harrisburg to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to South Carolina.

  • Can I find deals for business class flights from Harrisburg to South Carolina?

    Yes. Cheapflights offers flight deals from Harrisburg to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $98). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Harrisburg to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Miami flights
John F Kennedy Intl to Miami flights
John F Kennedy Intl to Fort Lauderdale flights
LaGuardia to Miami flights
Newark to West Palm Beach flights
Newark to Fort Lauderdale flights
LaGuardia to Fort Lauderdale flights
John F Kennedy Intl to West Palm Beach flights
John F Kennedy Intl to Orlando flights
John F Kennedy Intl to Los Angeles flights
John F Kennedy Intl to Las Vegas flights
Newark to Las Vegas flights
Dulles Intl to Miami flights
John F Kennedy Intl to Dallas/Fort Worth flights
Newark to Orlando flights
John F Kennedy Intl to Tampa flights
LaGuardia to West Palm Beach flights
LaGuardia to Tampa flights
LaGuardia to Dallas/Fort Worth flights
Newark to Tampa flights
LaGuardia to Orlando flights
John F Kennedy Intl to Sky Harbor Intl flights
Dulles Intl to Orlando flights
Newark to Sky Harbor Intl flights
Reagan-National to Miami flights
Newark to Los Angeles flights
Dulles Intl to Las Vegas flights
Philadelphia to Orlando flights
John F Kennedy Intl to New Orleans flights
LaGuardia to Hobby flights
Philadelphia to Miami flights
Dulles Intl to Dallas/Fort Worth flights
LaGuardia to Los Angeles flights
Philadelphia to Fort Lauderdale flights
LaGuardia to New Orleans flights
LaGuardia to Las Vegas flights
John F Kennedy Intl to Hobby flights
Reagan-National to Orlando flights
Reagan-National to Fort Lauderdale flights
Newark to New Orleans flights
John F Kennedy Intl to San Francisco flights
John F Kennedy Intl to Denver flights
Dulles Intl to Fort Lauderdale flights
Reagan-National to Las Vegas flights
Reagan-National to Los Angeles flights
John F Kennedy Intl to Salt Lake City flights
Reagan-National to Dallas/Fort Worth flights
Dulles Intl to Tampa flights
John F Kennedy Intl to Seattle flights
LaGuardia to Atlanta flights

Top 4 airlines flying from Harrisburg to South Carolina

Discover the top 4 airlines that operate flights from Harrisburg to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$101Average$156FlexibilityNo cancel feeOn-time88%
DeltaCheapest$164Average$343FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$373FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$352FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.