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South Carolina

$66+ Cheap flights from Harrisburg (MDT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — CHS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Harrisburg to South Carolina

Keep the following information in mind while searching for Harrisburg to South Carolina flight deals. Data was last updated September 17, 2025.

Round-trip from

$112
(Cheapflightsfares)

One-way from

$66
(Cheapflightsfares)

Popular in

November

Cheapest in

July

Average price

$180
From Harrisburg to South Carolina
Search Deals
One-way flight from Harrisburg to South Carolina
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Highest demand for flights based on searches. 24% potential increase in price ($88 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Harrisburg to South Carolina

Cheapest flights from Harrisburg to South Carolina
Explore the most affordable flight options available from Harrisburg to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/304:14 pmMDT - MYR
Nonstop1h 29mAllegiant Air
Sun 11/26:33 pmMYR - MDT
Nonstop1h 35mAllegiant Air
Deal found 9/16$112
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/23:37 pmMDT - MYR
Nonstop1h 29mAllegiant Air
Sun 10/55:56 pmMYR - MDT
Nonstop1h 35mAllegiant Air
Deal found 9/16$170
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/213:07 pmMDT - SAV
1 stop6h 50mAmerican Airlines
Sat 10/255:00 amSAV - MDT
1 stop4h 08mAmerican Airlines
Deal found 9/15$195
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:31 pmMDT - CLT
1 stop18h 13mFrontier
Mon 10/2012:04 pmCLT - MDT
1 stop5h 32mFrontier
Deal found 9/16$195
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:33 amMDT - SAV
2 stops8h 05mAmerican Airlines
Tue 11/46:32 amSAV - MDT
1 stop3h 52mAmerican Airlines
Deal found 9/14$200
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/610:57 amMDT - CLT
2 stops26h 53mFrontier
Thu 10/97:34 pmCLT - MDT
1 stop24h 01mFrontier
Deal found 9/16$215
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/28:21 pmMDT - CLT
1 stop16h 40mMultiple Airlines
Fri 10/38:51 pmCLT - MDT
1 stop23h 31mMultiple Airlines
Deal found 9/15$221
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/161:52 pmMDT - SAV
1 stop6h 05mAmerican Airlines
Sat 10/255:00 amSAV - MDT
1 stop4h 08mAmerican Airlines
Deal found 9/15$222
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:07 pmMDT - CHS
1 stop3h 49mAmerican Airlines
Thu 11/66:00 amCHS - MDT
1 stop4h 24mAmerican Airlines
Deal found 9/16$225
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/304:14 pmMDT - MYR
Nonstop1h 29mMultiple Airlines
Sun 11/27:58 pmMYR - MDT
1 stop15h 20mMultiple Airlines
Deal found 9/16$225
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:15 amMDT - SAV
1 stop3h 55mAmerican Airlines
Sat 11/18:59 amSAV - MDT
2 stops7h 59mAmerican Airlines
Deal found 9/17$227
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:25 pmMDT - GSP
1 stop3h 53mDelta
Sat 10/115:16 pmGSP - MDT
1 stop5h 52mDelta
Deal found 9/15$229

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Harrisburg to South Carolina that are best for you.

Fly from

Harrisburg

Fly to

South Carolina

Route

Depart

Return

Price

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

Thu 10/2

3:37 pm-5:06 pm

Nonstop1h 29m

Myrtle Beach Intl

Sun 10/5

5:56 pm-7:31 pm

Nonstop1h 35m

$170

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Tue 10/21

6:00 am-9:53 am

1 stop3h 53m

Savannah/Hilton Head

Sat 10/25

5:00 am-11:00 am

1 stop6h 00m

$195

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Sat 11/1

9:33 am-5:38 pm

2 stops8h 05m

Savannah/Hilton Head

Tue 11/4

6:32 am-10:24 am

1 stop3h 52m

$200

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

Thu 10/30

4:14 pm-5:43 pm

Nonstop1h 29m

Myrtle Beach Intl

Sun 11/2

7:58 pm-11:18 am

1 stop15h 20m

$225

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Fri 10/31

3:07 pm-6:56 pm

1 stop3h 49m

Charleston

Thu 11/6

6:00 am-10:24 am

1 stop4h 24m

$225

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Tue 10/7

6:25 pm-10:18 pm

1 stop3h 53m

Greenville

Sat 10/11

5:16 pm-11:08 pm

1 stop5h 52m

$229

HarrisburgColumbia

MDT - CAE

MDTCAE

Harrisburg

Wed 11/5

6:40 am-10:36 am

1 stop3h 56m

Columbia Metropolitan

Sat 11/8

11:04 am-3:01 pm

1 stop3h 57m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Tue 9/30

6:23 pm-11:34 pm

1 stop5h 11m

Greenville

Tue 10/7

6:44 pm-11:00 pm

1 stop4h 16m

$234

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Mon 9/29

6:23 pm-11:52 pm

1 stop5h 29m

Greenville

Tue 10/7

6:44 pm-11:00 pm

1 stop4h 16m

$234

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Wed 10/1

6:23 pm-11:34 pm

1 stop5h 11m

Greenville

Tue 10/7

6:44 pm-11:00 pm

1 stop4h 16m

$234

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 60 results
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Best time to book a flight from Harrisburg to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to South Carolina

What is the cheapest month to book a flight from Harrisburg to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $217). Flying from Harrisburg to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to SC?

Find hourly flight availability from Harrisburg to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Harrisburg to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Harrisburg to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
699 reviews
Delta
8.0
Very good
7,961 reviews

Boarding

8.2

Overall

8.0

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to South Carolina?

    If you book a flight to South Carolina from Harrisburg, you will be flying from Harrisburg, which is the city’s only airport. Harrisburg (MDT) is located 8.5 mi from the center of Harrisburg.

  • How long is the flight from Harrisburg to South Carolina?

    Allegiant Air, American Airlines, and Delta can get you from Harrisburg to South Carolina in just under 1h 29m. Your travel time can differ by up to 2h 24m. The distance between Harrisburg and South Carolina is about 465 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Harrisburg to South Carolina one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $66. However, be on the lookout for offers from Delta and American Airlines, as they are both options that can get you from Harrisburg to South Carolina for a low price.

  • What are the most popular routes from Harrisburg to South Carolina?

    The most popular flight routes from Harrisburg to South Carolina are Harrisburg - Savannah/Hilton Head, Harrisburg - Charleston and Harrisburg - Charlotte Douglas.

  • Can I find deals for flights from Harrisburg to South Carolina that include hotel bookings?

    Yes. In addition to deals on Harrisburg to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to South Carolina.

  • Can I find deals for business class flights from Harrisburg to South Carolina?

    Yes. Cheapflights offers flight deals from Harrisburg to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $217). Flying from Harrisburg to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Harrisburg to South Carolina

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Top 4 airlines flying from Harrisburg to South Carolina

Discover the top 4 airlines that operate flights from Harrisburg to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$100Average$154FlexibilityNo cancel feeOn-time88%
DeltaCheapest$164Average$317FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$375FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$429FlexibilityNo cancel feeOn-time69%

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