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South Carolina

$86+ Cheap flights from Harrisburg (MDT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — CHS
Mar 26 — Apr 21
Thu 3/26
Thu 4/2
1 adult, Economy
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Cheap flight deals from Harrisburg to South Carolina

Cheapest flights from Harrisburg to South Carolina
Explore the most affordable flight options available from Harrisburg to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 24, 2026.

This Gotogate deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/123:40 pm
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 4/162:03 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 2/24$131
This Cheapflightsfares deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:40 am
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 4/301:58 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 2/24$137
This Cheapflightsfares deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:40 am
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 4/236:04 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 2/23$141
This Gotogate deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:08 pm
MDT
-
MYR
Nonstop1h 36m
Allegiant Air
Sat 6/135:34 pm
MYR
-
MDT
Nonstop1h 34m
Allegiant Air
Deal found 2/21$142
This Cheapflightsfares deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:40 am
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 5/72:28 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 2/23$150
This Cheapflightsfares deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:40 am
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Sun 5/102:28 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 2/23$167
This Cheapflightsfares deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:10 pm
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 5/142:28 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 2/22$171
This Frontier deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2410:18 pm
MDT
-
CLT
1 stop9h 45m
Frontier
Thu 3/262:32 pm
CLT
-
MDT
1 stop6h 56m
Frontier
Deal found 2/20$189
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:25 pm
MDT
-
SAV
1 stop6h 18m
Delta
Tue 10/277:00 am
SAV
-
MDT
1 stop7h 09m
Delta
Deal found 2/21$197
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:26 pm
MDT
-
CLT
1 stop14h 55m
Multiple Airlines
Wed 3/181:59 pm
CLT
-
MDT
1 stop18h 25m
Multiple Airlines
Deal found 2/21$199
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2412:30 pm
MDT
-
SAV
2 stops8h 17m
Delta
Wed 10/288:45 am
SAV
-
MDT
1 stop5h 24m
Delta
Deal found 2/21$202
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:16 pm
MDT
-
MYR
1 stop15h 25m
Multiple Airlines
Thu 4/301:58 pm
MYR
-
MDT
Nonstop1h 38m
Multiple Airlines
Deal found 2/20$207

Find flight deals from Harrisburg to South Carolina

Keep the following information in mind while searching for Harrisburg to South Carolina flight deals. Data was last updated February 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$137
(Cheapflightsfares)

One-way from

$74
(Kiwi.com)

Popular in

December

Cheapest in

July

Average price

$364
Provider with most accurate pricing for Harrisburg-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Myrtle Beach Intl flights.
Search Deals
From Harrisburg to South Carolina
Search Deals
One-way flight from Harrisburg to South Carolina
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($84 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2026.
Use the filters below to find and compare flights from Harrisburg to South Carolina that are best for you.

Fly from

Harrisburg

Fly to

South Carolina

Route

Depart

Return

Price

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Thu 7/23

2:56 pm-8:17 pm

1 stop5h 21m

Greenville

Sun 7/26

7:15 am-11:51 am

1 stop4h 36m

$249

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Mon 4/20

6:19 pm-12:22 am

1 stop6h 03m

Charleston

Wed 4/22

6:46 pm-11:03 pm

1 stop4h 17m

$254

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Wed 5/20

6:20 am-10:50 am

1 stop4h 30m

Greenville

Mon 5/25

7:20 am-12:12 pm

1 stop4h 52m

$278

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Wed 3/25

6:15 am-10:04 am

1 stop3h 49m

Charleston

Mon 3/30

6:00 am-9:44 am

1 stop3h 44m

$289

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Wed 4/1

6:15 am-11:54 am

1 stop5h 39m

Greenville

Tue 4/7

7:42 pm-11:28 pm

1 stop3h 46m

$299

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Wed 4/29

6:19 pm-11:56 pm

1 stop5h 37m

Greenville

Sun 5/3

7:59 pm-11:59 pm

1 stop4h 00m

$299

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Wed 7/8

6:30 am-2:16 pm

1 stop7h 46m

Savannah/Hilton Head

Sat 7/18

3:14 pm-9:29 pm

1 stop6h 15m

$325

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Mon 7/6

6:15 am-10:52 am

1 stop4h 37m

Savannah/Hilton Head

Mon 7/13

11:30 am-4:54 pm

1 stop5h 24m

$329

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Sun 3/8

6:15 am-12:05 pm

1 stop5h 50m

Charleston

Thu 3/12

12:46 pm-9:05 pm

1 stop8h 19m

$339

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Wed 4/8

6:15 am-2:40 pm

1 stop8h 25m

Savannah/Hilton Head

Fri 4/17

11:31 am-4:46 pm

1 stop5h 15m

$339

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 60 results
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6

Best time to book a flight from Harrisburg to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to South Carolina

What is the cheapest month to book a flight from Harrisburg to South Carolina?

Currently, June is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $98). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Harrisburg to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 24, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Harrisburg to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,239 reviews

Crew

8.5

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,239 reviews
Delta
7.9
Good
8,239 reviews

Crew

8.5

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,344 reviews
Delta
7.9
Good
8,239 reviews

Crew

8.5

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,344 reviews
Delta
7.9
Good
8,239 reviews

Crew

8.5

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
713 reviews
Delta
7.9
Good
8,239 reviews

Crew

8.5

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to South Carolina?

    If you book a flight to South Carolina from Harrisburg, you will be flying from Harrisburg, which is the city’s only airport. Harrisburg (MDT) is located 8.5 mi from the center of Harrisburg.

  • How long is the flight from Harrisburg to South Carolina?

    Allegiant Air, Frontier, and Delta can get you from Harrisburg to South Carolina in just under 1h 28m. Your travel time can differ by up to 8h 17m. The distance between Harrisburg and South Carolina is about 465 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Harrisburg to South Carolina one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $58. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Harrisburg to South Carolina for a low price.

  • What are the most popular routes from Harrisburg to South Carolina?

    The most popular flight routes from Harrisburg to South Carolina are Harrisburg - Charlotte Douglas, Harrisburg - Charleston and Harrisburg - Myrtle Beach Intl.

  • Can I find deals for flights from Harrisburg to South Carolina that include hotel bookings?

    Yes. In addition to deals on Harrisburg to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to South Carolina.

  • Can I find deals for business class flights from Harrisburg to South Carolina?

    Yes. Cheapflights offers flight deals from Harrisburg to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $98). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Harrisburg to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Harrisburg to South Carolina

Discover the top 4 airlines that operate flights from Harrisburg to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$98Average$154FlexibilityNo cancel feeOn-time88%
DeltaCheapest$189Average$346FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$365FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$228Average$345FlexibilityNo cancel feeOn-time69%

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