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South Carolina

$86+ Cheap flights from Harrisburg (MDT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — CHS
Dec 19 — Dec 261
Fri 12/19
Fri 12/26
1 adult, Economy
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Find flight deals from Harrisburg to South Carolina

Cheapest flights from Harrisburg to South Carolina
Explore the most affordable flight options available from Harrisburg to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 19, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1711:10 amMDT - GSP
1 stop28h 05mMultiple Airlines
Mon 12/228:03 pmGSP - MDT
1 stop13h 58mMultiple Airlines
Deal found 11/18$213
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:27 pmMDT - GSP
1 stop4h 13mDelta
Sat 12/135:35 amGSP - MDT
1 stop6h 46mDelta
Deal found 11/17$229
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:00 amMDT - CAE
1 stop3h 39mAmerican Airlines
Thu 12/257:05 amCAE - MDT
1 stop3h 30mAmerican Airlines
Deal found 11/18$229
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:02 pmMDT - GSP
1 stop17h 02mMultiple Airlines
Mon 12/228:03 pmGSP - MDT
1 stop13h 58mMultiple Airlines
Deal found 11/18$231
This Kiwi.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2211:08 amMDT - CLT
1 stop20h 51mMultiple Airlines
Mon 11/243:51 pmCLT - MDT
1 stop18h 22mMultiple Airlines
Deal found 11/17$241
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:00 amMDT - GSP
1 stop3h 25mAmerican Airlines
Thu 12/116:39 amGSP - MDT
1 stop4h 03mAmerican Airlines
Deal found 11/18$244
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:00 amMDT - SAV
1 stop3h 38mAmerican Airlines
Thu 12/256:44 amSAV - MDT
1 stop3h 51mAmerican Airlines
Deal found 11/18$249
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/199:47 amMDT - GSP
1 stop11h 27mMultiple Airlines
Mon 12/228:03 pmGSP - MDT
1 stop13h 58mMultiple Airlines
Deal found 11/18$257
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:00 pmMDT - GSP
1 stop4h 42mDelta
Sun 12/76:45 amGSP - MDT
1 stop4h 03mDelta
Deal found 11/18$259
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:27 pmMDT - CAE
1 stop4h 04mDelta
Sun 12/75:34 amCAE - MDT
1 stop5h 14mDelta
Deal found 11/18$259
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:00 amMDT - MYR
1 stop4h 34mDelta
Wed 12/245:12 pmMYR - MDT
1 stop5h 10mDelta
Deal found 11/17$259
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/172:55 pmMDT - GSP
1 stop5h 53mAmerican Airlines
Wed 12/245:39 amGSP - MDT
1 stop3h 31mAmerican Airlines
Deal found 11/19$261

Cheap flight deals from Harrisburg to South Carolina

Keep the following information in mind while searching for Harrisburg to South Carolina flight deals. Data was last updated November 19, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$213
(Kiwi.com)

One-way from

$86
(Trip.com)

Popular in

December

Cheapest in

July

Average price

$346
Provider with most accurate pricing for Harrisburg-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Myrtle Beach Intl flights.
Search Deals
From Harrisburg to South Carolina
Search Deals
One-way flight from Harrisburg to South Carolina
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($110 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
Use the filters below to find and compare flights from Harrisburg to South Carolina that are best for you.

Fly from

Harrisburg

Fly to

South Carolina

Route

Depart

Return

Price

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Wed 12/17

11:10 am-3:15 pm

1 stop28h 05m

Greenville

Mon 12/22

8:03 pm-10:01 am

1 stop13h 58m

$213

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Thu 1/8

4:47 pm-9:11 pm

1 stop4h 24m

Charleston

Sun 1/11

4:07 pm-8:14 pm

1 stop4h 07m

$217

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Tue 4/7

6:15 am-9:58 am

1 stop3h 43m

Greenville

Tue 4/21

7:45 pm-11:17 pm

1 stop3h 32m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Fri 12/12

7:27 pm-11:40 pm

1 stop4h 13m

Greenville

Sat 12/13

5:35 am-12:21 pm

1 stop6h 46m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Fri 12/12

6:40 am-10:34 am

1 stop3h 54m

Greenville

Sat 12/13

6:39 am-10:42 am

1 stop4h 03m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Thu 1/29

10:34 am-2:19 pm

1 stop3h 45m

Greenville

Wed 2/4

6:30 am-2:15 pm

1 stop7h 45m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Mon 12/15

5:00 pm-9:42 pm

1 stop4h 42m

Greenville

Thu 12/25

7:30 am-12:00 pm

1 stop4h 30m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Thu 12/18

7:27 pm-11:40 pm

1 stop4h 13m

Greenville

Thu 12/25

7:30 am-12:00 pm

1 stop4h 30m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Sat 1/31

4:49 pm-8:48 pm

1 stop3h 59m

Greenville

Tue 2/3

6:00 am-10:17 am

1 stop4h 17m

$229

HarrisburgColumbia

MDT - CAE

MDTCAE

Harrisburg

Tue 1/27

6:15 am-10:17 am

1 stop4h 02m

Columbia Metropolitan

Mon 2/2

2:37 pm-9:05 pm

1 stop6h 28m

$229

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/18

Showing 1-10 of 60 results
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Best time to book a flight from Harrisburg to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to South Carolina

What is the cheapest month to book a flight from Harrisburg to South Carolina?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $97). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $172). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to SC?

Find hourly flight availability from Harrisburg to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 19, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 29% on flights from Harrisburg to South Carolina by exploring options for tickets in the afternoon.

What is the cheapest day to fly from Harrisburg to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Harrisburg to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Harrisburg to South Carolina flight should consider departing on Friday at noon when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Harrisburg to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 19, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Harrisburg to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,004 reviews
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,025 reviews
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,046 reviews
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
700 reviews
Delta
7.9
Good
8,004 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to South Carolina?

    If you book a flight to South Carolina from Harrisburg, you will be flying from Harrisburg, which is the city’s only airport. Harrisburg (MDT) is located 8.5 mi from the center of Harrisburg.

  • How long is the flight from Harrisburg to South Carolina?

    American Airlines, United Airlines, and Delta can get you from Harrisburg to South Carolina in just under 3h 43m. Your travel time can differ by up to 41m. The distance between Harrisburg and South Carolina is about 472 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Harrisburg to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $86. However, be on the lookout for offers from American Airlines and Allegiant Air, as they are both options that can get you from Harrisburg to South Carolina for a low price.

  • What are the most popular routes from Harrisburg to South Carolina?

    The most popular flight routes from Harrisburg to South Carolina are Harrisburg - Charleston, Harrisburg - Greenville and Harrisburg - Charlotte Douglas.

  • Can I find deals for flights from Harrisburg to South Carolina that include hotel bookings?

    Yes. In addition to deals on Harrisburg to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to South Carolina.

  • Can I find deals for business class flights from Harrisburg to South Carolina?

    Yes. Cheapflights offers flight deals from Harrisburg to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $97). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $172). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Harrisburg to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Harrisburg to South Carolina

Discover the top 4 airlines that operate flights from Harrisburg to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$101Average$155FlexibilityNo cancel feeOn-time88%
DeltaCheapest$164Average$319FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$375FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$429FlexibilityNo cancel feeOn-time69%

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