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South Carolina

$75+ Cheap flights from Harrisburg (MDT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — CHS
Jan 9 — Jan 161
Fri 1/9
Fri 1/16
1 adult, Economy
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Cheap flight deals from Harrisburg to South Carolina

Cheapest flights from Harrisburg to South Carolina
Explore the most affordable flight options available from Harrisburg to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 10, 2025.

This Frontier deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2310:56 amMDT - CLT
1 stop9h 33mFrontier
Mon 12/299:43 pmCLT - MDT
1 stop12h 18mFrontier
Deal found 12/8$162
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:53 pmMDT - CLT
1 stop23h 16mMultiple Airlines
Sat 12/209:02 pmCLT - MDT
1 stop13h 14mMultiple Airlines
Deal found 12/9$260
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:30 amMDT - SAV
1 stop7h 59mUnited Airlines
Mon 12/294:55 pmSAV - MDT
1 stop7h 12mUnited Airlines
Deal found 12/10$267
This Delta deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1512:41 pmMDT - CHS
1 stop5h 35mDelta
Fri 12/195:25 amCHS - MDT
1 stop5h 23mDelta
Deal found 12/8$269
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:22 amMDT - MYR
1 stop5h 37mAmerican Airlines
Mon 1/127:19 pmMYR - MDT
1 stop4h 18mAmerican Airlines
Deal found 12/8$274
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/209:02 pmMDT - CAE
1 stop18h 05mAllegiant Air
Sat 12/272:37 pmCAE - MDT
1 stop17h 50mAllegiant Air
Deal found 12/9$277
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1711:10 amMDT - CLT
1 stop26h 17mMultiple Airlines
Sat 12/209:02 pmCLT - MDT
1 stop13h 14mMultiple Airlines
Deal found 12/9$281
This American Airlines deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:47 amMDT - GSP
1 stop3h 47mAmerican Airlines
Sun 12/145:25 amGSP - MDT
1 stop3h 36mAmerican Airlines
Deal found 12/7$294
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/176:30 amMDT - CHS
1 stop7h 25mUnited Airlines
Fri 12/194:59 pmCHS - MDT
1 stop7h 08mUnited Airlines
Deal found 12/10$296
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/189:44 amMDT - MYR
1 stop5h 52mAmerican Airlines
Sun 12/217:46 pmMYR - MDT
1 stop4h 33mAmerican Airlines
Deal found 12/8$299
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:00 amMDT - CHS
1 stop3h 35mAmerican Airlines
Fri 12/266:30 pmCHS - MDT
1 stop3h 42mAmerican Airlines
Deal found 12/8$304
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:53 pmMDT - CLT
1 stop17h 03mMultiple Airlines
Fri 12/199:04 pmCLT - MDT
1 stop23h 08mMultiple Airlines
Deal found 12/9$313

Find flight deals from Harrisburg to South Carolina

Keep the following information in mind while searching for Harrisburg to South Carolina flight deals. Data was last updated December 10, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$162
(Frontier)

One-way from

$75
(Trip.com)

Popular in

December

Cheapest in

July

Average price

$395
Provider with most accurate pricing for Harrisburg-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Myrtle Beach Intl flights.
Search Deals
From Harrisburg to South Carolina
Search Deals
One-way flight from Harrisburg to South Carolina
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($92 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 10, 2025.
Use the filters below to find and compare flights from Harrisburg to South Carolina that are best for you.

Fly from

Harrisburg

Fly to

South Carolina

Route

Depart

Return

Price

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

Sun 4/12

11:45 am-1:13 pm

Nonstop1h 28m

Myrtle Beach Intl

Thu 4/16

2:03 pm-3:41 pm

Nonstop1h 38m

$132

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Sat 2/14

7:52 pm-11:58 pm

1 stop4h 06m

Savannah/Hilton Head

Sat 2/21

5:00 am-10:57 am

1 stop5h 57m

$195

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Tue 1/6

10:34 am-2:47 pm

1 stop4h 13m

Savannah/Hilton Head

Tue 1/13

10:10 am-4:34 pm

1 stop6h 24m

$222

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Thu 1/1

7:34 pm-12:13 am

1 stop4h 39m

Savannah/Hilton Head

Sun 1/4

8:15 pm-12:19 am

1 stop4h 04m

$222

HarrisburgColumbia

MDT - CAE

MDTCAE

Harrisburg

Thu 1/1

6:15 am-10:05 am

1 stop3h 50m

Columbia Metropolitan

Wed 1/7

2:37 pm-9:05 pm

1 stop6h 28m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Tue 2/3

4:47 pm-8:48 pm

1 stop4h 01m

Greenville

Sat 2/7

6:23 pm-10:27 pm

1 stop4h 04m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Fri 1/23

3:03 pm-8:59 pm

1 stop5h 56m

Greenville

Sat 1/24

6:00 am-10:54 am

1 stop4h 54m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Sat 1/31

11:19 am-5:09 pm

1 stop5h 50m

Greenville

Tue 2/3

6:00 am-10:54 am

1 stop4h 54m

$229

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

Wed 2/4

4:47 pm-8:54 pm

1 stop4h 07m

Myrtle Beach Intl

Sat 2/21

5:11 am-10:57 am

1 stop5h 46m

$229

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

Sat 2/7

4:49 pm-8:54 pm

1 stop4h 05m

Myrtle Beach Intl

Sat 2/21

6:38 pm-10:15 pm

1 stop3h 37m

$229

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/9

Showing 1-10 of 60 results
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Best time to book a flight from Harrisburg to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to South Carolina

What is the cheapest month to book a flight from Harrisburg to South Carolina?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $97). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to SC?

Find hourly flight availability from Harrisburg to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 10, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 29% on flights from Harrisburg to South Carolina by exploring options for tickets in the afternoon.

What is the cheapest day to fly from Harrisburg to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Harrisburg to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Harrisburg to South Carolina flight should consider departing on Friday at noon when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 10, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Harrisburg to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,048 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
699 reviews
Delta
7.9
Good
8,007 reviews

Boarding

8.1

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to South Carolina?

    If you book a flight to South Carolina from Harrisburg, you will be flying from Harrisburg, which is the city’s only airport. Harrisburg (MDT) is located 8.5 mi from the center of Harrisburg.

  • How long is the flight from Harrisburg to South Carolina?

    Allegiant Air, American Airlines, and United Airlines can get you from Harrisburg to South Carolina in just under 1h 28m. Your travel time can differ by up to 2h 45m. The distance between Harrisburg and South Carolina is about 465 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Harrisburg to South Carolina?

    The most popular flight routes from Harrisburg to South Carolina are Harrisburg - Myrtle Beach Intl, Harrisburg - Savannah/Hilton Head and Harrisburg - Charlotte Douglas.

  • Can I find deals for flights from Harrisburg to South Carolina that include hotel bookings?

    Yes. In addition to deals on Harrisburg to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to South Carolina.

  • Can I find deals for business class flights from Harrisburg to South Carolina?

    Yes. Cheapflights offers flight deals from Harrisburg to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $97). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Harrisburg to South Carolina

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Top 4 airlines flying from Harrisburg to South Carolina

Discover the top 4 airlines that operate flights from Harrisburg to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 10, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$101Average$155FlexibilityNo cancel feeOn-time88%
DeltaCheapest$164Average$324FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$377FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$382FlexibilityNo cancel feeOn-time69%

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