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South Carolina

$100+ Cheap flights from Harrisburg (MDT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/14. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Harrisburg to South Carolina

Cheapest flights from Harrisburg to South Carolina
Explore the most affordable flight options available from Harrisburg to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Booking.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:57 pmMDT - CLT
1 stop19h 13mFrontier
Mon 11/179:57 amCLT - MDT
1 stop10h 15mFrontier
Deal found 10/28$155
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/304:14 pmMDT - MYR
Nonstop1h 29mAllegiant Air
Sun 11/26:33 pmMYR - MDT
Nonstop1h 35mAllegiant Air
Deal found 10/29$187
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:15 amMDT - SAV
1 stop4h 31mUnited Airlines
Sat 12/610:12 amSAV - MDT
1 stop6h 41mUnited Airlines
Deal found 10/30$195
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:27 pmMDT - SAV
1 stop4h 32mDelta
Sat 12/63:09 pmSAV - MDT
2 stops7h 58mDelta
Deal found 10/30$202
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:25 pmMDT - SAV
1 stop6h 54mAmerican Airlines
Sun 12/76:30 amSAV - MDT
1 stop4h 12mAmerican Airlines
Deal found 10/30$222
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/175:00 pmMDT - GSP
1 stop4h 59mDelta
Mon 11/246:45 amGSP - MDT
1 stop4h 14mDelta
Deal found 10/30$244
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:00 amMDT - CHS
1 stop3h 29mAmerican Airlines
Sat 11/227:53 pmCHS - MDT
1 stop4h 29mAmerican Airlines
Deal found 10/29$249
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amMDT - SAV
1 stop5h 00mDelta
Sun 12/75:30 amSAV - MDT
1 stop5h 18mDelta
Deal found 10/30$249
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:41 pmMDT - SAV
2 stops11h 18mDelta
Sun 12/76:41 amSAV - MDT
1 stop4h 07mDelta
Deal found 10/29$254
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:57 pmMDT - CLT
2 stops25h 11mMultiple Airlines
Mon 11/179:57 amCLT - MDT
1 stop10h 15mMultiple Airlines
Deal found 10/28$258
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/95:00 amMDT - CHS
1 stop3h 29mAmerican Airlines
Thu 11/206:32 pmCHS - MDT
1 stop5h 50mAmerican Airlines
Deal found 10/29$259
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/124:25 pmMDT - GSP
1 stop4h 21mAmerican Airlines
Sun 11/165:15 amGSP - MDT
1 stop3h 38mAmerican Airlines
Deal found 10/28$259

Cheap flight deals from Harrisburg to South Carolina

Keep the following information in mind while searching for Harrisburg to South Carolina flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$195
(United Airlines)

One-way from

$100
(Booking.com)

Popular in

December

Cheapest in

July

Average price

$229
Provider with most accurate pricing for Harrisburg-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Myrtle Beach Intl flights.
Search Deals
From Harrisburg to South Carolina
Search Deals
One-way flight from Harrisburg to South Carolina
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($108 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Harrisburg to South Carolina that are best for you.

Fly from

Harrisburg

Fly to

South Carolina

Route

Depart

Return

Price

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Tue 2/24

2:33 pm-7:23 pm

1 stop4h 50m

Savannah/Hilton Head

Tue 3/3

9:50 am-1:56 pm

1 stop4h 06m

$195

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Sat 2/21

6:29 am-2:43 pm

1 stop8h 14m

Savannah/Hilton Head

Tue 3/3

9:40 am-4:44 pm

1 stop7h 04m

$195

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Sat 2/21

2:07 pm-8:00 pm

1 stop5h 53m

Savannah/Hilton Head

Sat 2/28

9:40 am-4:44 pm

1 stop7h 04m

$195

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Wed 12/3

7:27 pm-11:59 pm

1 stop4h 32m

Savannah/Hilton Head

Sat 12/6

3:09 pm-11:07 pm

2 stops7h 58m

$202

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Wed 12/3

2:55 pm-8:52 pm

1 stop5h 57m

Savannah/Hilton Head

Sun 12/7

6:30 am-10:42 am

1 stop4h 12m

$222

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Wed 12/3

5:40 am-12:13 pm

1 stop6h 33m

Savannah/Hilton Head

Sun 12/21

6:01 pm-12:19 am

1 stop6h 18m

$222

HarrisburgColumbia

MDT - CAE

MDTCAE

Harrisburg

Tue 3/24

6:00 am-11:20 am

1 stop5h 20m

Columbia Metropolitan

Sat 3/28

5:10 pm-11:40 pm

1 stop6h 30m

$229

HarrisburgColumbia

MDT - CAE

MDTCAE

Harrisburg

Thu 1/22

12:43 pm-5:07 pm

1 stop4h 24m

Columbia Metropolitan

Sun 1/25

11:02 am-2:38 pm

1 stop3h 36m

$229

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Mon 11/17

5:00 pm-9:59 pm

1 stop4h 59m

Greenville

Mon 11/24

6:45 am-10:59 am

1 stop4h 14m

$244

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Thu 11/20

5:00 am-8:29 am

1 stop3h 29m

Charleston

Sat 11/22

7:53 pm-12:22 am

1 stop4h 29m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 60 results
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Best time to book a flight from Harrisburg to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to South Carolina

What is the cheapest month to book a flight from Harrisburg to South Carolina?

Currently, January is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $97). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $182). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to SC?

Find hourly flight availability from Harrisburg to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 29% on flights from Harrisburg to South Carolina by exploring options for tickets in the afternoon.

What is the cheapest day to fly from Harrisburg to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Harrisburg to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Harrisburg to South Carolina flight should consider departing on Friday at noon when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Harrisburg to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Allegiant Air
7.2
Good
694 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to South Carolina?

    If you book a flight to South Carolina from Harrisburg, you will be flying from Harrisburg, which is the city’s only airport. Harrisburg (MDT) is located 8.5 mi from the center of Harrisburg.

  • How long is the flight from Harrisburg to South Carolina?

    United Airlines, Delta, and American Airlines can get you from Harrisburg to South Carolina in just under 4h 32m. Your travel time can differ by up to 1h 25m. The distance between Harrisburg and South Carolina is about 609 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Harrisburg to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $108. However, be on the lookout for offers from Allegiant Air and United Airlines, as they are both options that can get you from Harrisburg to South Carolina for a low price.

  • What are the most popular routes from Harrisburg to South Carolina?

    The most popular flight routes from Harrisburg to South Carolina are Harrisburg - Charlotte Douglas, Harrisburg - Myrtle Beach Intl and Harrisburg - Charleston.

  • Can I find deals for flights from Harrisburg to South Carolina that include hotel bookings?

    Yes. In addition to deals on Harrisburg to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to South Carolina.

  • Can I find deals for business class flights from Harrisburg to South Carolina?

    Yes. Cheapflights offers flight deals from Harrisburg to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $97). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $182). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Harrisburg to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Harrisburg to South Carolina

Discover the top 4 airlines that operate flights from Harrisburg to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$101Average$154FlexibilityNo cancel feeOn-time88%
DeltaCheapest$164Average$314FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$377FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$233Average$429FlexibilityNo cancel feeOn-time69%

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