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South Carolina

$74+ Cheap flights from Harrisburg (MDT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — CHS
Apr 26 — May 31
Sun 4/26
Sun 5/3
1 adult, Economy
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Cheap flight deals from Harrisburg to South Carolina

Cheapest flights from Harrisburg to South Carolina
Explore the most affordable flight options available from Harrisburg to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 27, 2026.

This Booking.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:10 pm
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 5/142:28 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 3/25$114
This Cheapflightsfares deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1911:40 am
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 4/236:04 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 3/25$121
This Cheapflightsfares deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/123:40 pm
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 4/162:03 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 3/25$137
This Cheapflightsfares deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/213:54 pm
MDT
-
MYR
Nonstop1h 31m
Allegiant Air
Thu 6/46:26 pm
MYR
-
MDT
Nonstop1h 34m
Allegiant Air
Deal found 3/26$138
This Cheapflightsfares deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:08 pm
MDT
-
MYR
Nonstop1h 36m
Allegiant Air
Sat 6/135:34 pm
MYR
-
MDT
Nonstop1h 34m
Allegiant Air
Deal found 3/24$142
This Booking.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:46 pm
MDT
-
MYR
Nonstop1h 28m
Allegiant Air
Thu 4/301:58 pm
MYR
-
MDT
Nonstop1h 38m
Allegiant Air
Deal found 3/23$148
This Cheapflightsfares deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/273:08 pm
MDT
-
MYR
Nonstop1h 36m
Allegiant Air
Sat 7/45:35 pm
MYR
-
MDT
Nonstop1h 34m
Allegiant Air
Deal found 3/23$159
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1310:58 pm
MDT
-
CLT
1 stop10h 20m
Multiple Airlines
Thu 4/169:54 pm
CLT
-
MDT
1 stop19h 32m
Multiple Airlines
Deal found 3/24$206
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:57 pm
MDT
-
CLT
1 stop15h 13m
Multiple Airlines
Sat 5/309:54 pm
CLT
-
MDT
1 stop19h 13m
Multiple Airlines
Deal found 3/24$223
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:19 pm
MDT
-
SAV
1 stop5h 40m
Delta
Wed 5/136:36 am
SAV
-
MDT
1 stop4h 31m
Delta
Deal found 3/24$235
This Kiwi.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:16 pm
MDT
-
CLT
1 stop14h 54m
Multiple Airlines
Sun 5/106:41 pm
CLT
-
MDT
1 stop22h 45m
Multiple Airlines
Deal found 3/22$236
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:57 pm
MDT
-
CLT
1 stop15h 13m
Multiple Airlines
Wed 6/39:54 pm
CLT
-
MDT
1 stop19h 14m
Multiple Airlines
Deal found 3/24$246

Find flight deals from Harrisburg to South Carolina

Keep the following information in mind while searching for Harrisburg to South Carolina flight deals. Data was last updated March 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$114
(Booking.com)

One-way from

$74
(Cheapflightsfares)

Popular in

March

Cheapest in

July

Average price

$409
Provider with most accurate pricing for Harrisburg-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Myrtle Beach Intl flights.
Search Deals
From Harrisburg to South Carolina
Search Deals
One-way flight from Harrisburg to South Carolina
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($60 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 27, 2026.
Use the filters below to find and compare flights from Harrisburg to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

Thu 7/16

4:09 pm-5:44 pm

Nonstop1h 35m

Myrtle Beach Intl

Sat 7/25

5:35 pm-7:09 pm

Nonstop1h 34m

$194

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

Tue 4/21

6:15 am-2:17 pm

1 stop8h 02m

Myrtle Beach Intl

Tue 4/28

3:15 pm-9:18 pm

1 stop6h 03m

$299

HarrisburgMyrtle Beach

MDT - MYR

MDTMYR

Harrisburg

Tue 4/21

4:19 pm-12:14 am

2 stops7h 55m

Myrtle Beach Intl

Tue 4/28

7:02 pm-11:59 pm

1 stop4h 57m

$304

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Sat 4/25

2:41 pm-6:59 pm

1 stop4h 18m

Greenville

Tue 4/28

10:33 am-1:55 pm

1 stop3h 22m

$304

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Fri 4/24

6:19 pm-11:25 pm

1 stop5h 06m

Charleston

Tue 5/5

5:57 pm-11:59 pm

1 stop6h 02m

$305

HarrisburgGreenville

MDT - GSP

MDTGSP

Harrisburg

Fri 4/10

6:32 pm-11:54 pm

1 stop5h 22m

Greenville

Tue 4/14

5:50 pm-11:59 pm

1 stop6h 09m

$309

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Thu 8/6

2:57 pm-9:10 pm

1 stop6h 13m

Savannah/Hilton Head

Fri 8/14

6:50 pm-11:40 pm

1 stop4h 50m

$311

HarrisburgSavannah

MDT - SAV

MDTSAV

Harrisburg

Sat 8/29

6:30 am-2:11 pm

1 stop7h 41m

Savannah/Hilton Head

Wed 9/2

1:00 pm-7:30 pm

1 stop6h 30m

$315

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Sun 5/3

6:15 am-10:03 am

1 stop3h 48m

Charleston

Sat 5/9

7:44 pm-11:28 pm

1 stop3h 44m

$329

HarrisburgCharleston

MDT - CHS

MDTCHS

Harrisburg

Mon 4/6

6:32 pm-12:16 am

1 stop5h 44m

Charleston

Wed 4/8

6:09 pm-11:41 pm

1 stop5h 32m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
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6

Best time to book a flight from Harrisburg to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to South Carolina

What is the cheapest month to book a flight from Harrisburg to South Carolina?

Currently, June is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $99). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Harrisburg to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 27, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAllegiant Air from Harrisburg to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,346 reviews

Food

7.2

Overall

7.9

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,346 reviews
Delta
7.9
Good
8,346 reviews

Food

7.2

Overall

7.9

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,494 reviews
Delta
7.9
Good
8,346 reviews

Food

7.2

Overall

7.9

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.3
Good
710 reviews
Delta
7.9
Good
8,346 reviews

Food

7.2

Overall

7.9

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,514 reviews
Delta
7.9
Good
8,346 reviews

Food

7.2

Overall

7.9

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Harrisburg to South Carolina?

    If you book a flight to South Carolina from Harrisburg, you will be flying from Harrisburg, which is the city’s only airport. Harrisburg (MDT) is located 8.5 mi from the center of Harrisburg.

  • How long is the flight from Harrisburg to South Carolina?

    Allegiant Air, United Airlines, and Delta can get you from Harrisburg to South Carolina in just under 1h 28m. Your travel time can differ by up to 3h 38m. The distance between Harrisburg and South Carolina is about 465 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Harrisburg to South Carolina one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $58. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Harrisburg to South Carolina for a low price.

  • What are the most popular routes from Harrisburg to South Carolina?

    The most popular flight routes from Harrisburg to South Carolina are Harrisburg - Charleston, Harrisburg - Charlotte Douglas and Harrisburg - Myrtle Beach Intl.

  • Can I find deals for flights from Harrisburg to South Carolina that include hotel bookings?

    Yes. In addition to deals on Harrisburg to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to South Carolina.

  • Can I find deals for business class flights from Harrisburg to South Carolina?

    Yes. Cheapflights offers flight deals from Harrisburg to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to South Carolina?

    Currently, June is the cheapest month in which you can book a flight from Harrisburg to South Carolina (average of $99). Flying from Harrisburg to South Carolina in November is currently the most expensive (average of $181). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Harrisburg to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Harrisburg to South Carolina

Discover the top 4 airlines that operate flights from Harrisburg to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$99Average$157FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$159Average$330FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$213Average$363FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$346FlexibilityNo cancel feeOn-timeN/A

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