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South Carolina

$37+ Cheap flights from Florida Keys to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/23. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Mar 17 — Mar 241
Tue 3/17
Tue 3/24
1 adult, Economy
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Cheap flight deals from Florida Keys to South Carolina

Cheapest flights from Florida Keys to South Carolina
Explore the most affordable flight options available from Florida Keys to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 15, 2026.

This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:57 am
MIA
-
CLT
Nonstop2h 10m
Spirit Airlines
Sun 3/157:00 am
CLT
-
MIA
Nonstop2h 02m
Spirit Airlines
Deal found 2/11$74
This CheapOair deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/99:57 am
MIA
-
CLT
Nonstop2h 10m
Spirit Airlines
Sat 4/117:00 am
CLT
-
MIA
Nonstop2h 02m
Spirit Airlines
Deal found 2/14$75
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/199:57 am
MIA
-
CLT
Nonstop2h 10m
Spirit Airlines
Mon 3/237:00 am
CLT
-
MIA
Nonstop2h 02m
Spirit Airlines
Deal found 2/11$76
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/271:10 pm
MIA
-
CLT
Nonstop2h 20m
Frontier
Thu 3/52:21 pm
CLT
-
MIA
Nonstop2h 15m
Frontier
Deal found 2/11$77
This CheapOair deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/249:57 am
MIA
-
CLT
Nonstop2h 10m
Multiple Airlines
Wed 3/2510:42 am
CLT
-
MIA
Nonstop2h 15m
Multiple Airlines
Deal found 2/15$79
This Cheapflightsfares deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/209:57 am
MIA
-
CLT
Nonstop2h 10m
Spirit Airlines
Mon 3/237:00 am
CLT
-
MIA
Nonstop2h 02m
Spirit Airlines
Deal found 2/15$80
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:55 am
MIA
-
CLT
Nonstop2h 17m
Multiple Airlines
Tue 3/317:00 am
CLT
-
MIA
Nonstop2h 02m
Multiple Airlines
Deal found 2/12$82
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:13 pm
MIA
-
CLT
Nonstop2h 15m
Multiple Airlines
Sun 5/172:28 pm
CLT
-
MIA
Nonstop2h 17m
Multiple Airlines
Deal found 2/11$83
This CheapOair deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/53:30 pm
MIA
-
CLT
Nonstop2h 20m
Frontier
Mon 3/99:53 pm
CLT
-
MIA
Nonstop2h 12m
Frontier
Deal found 2/13$84
This CheapOair deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/199:57 am
MIA
-
CLT
Nonstop2h 10m
Multiple Airlines
Mon 3/239:53 pm
CLT
-
MIA
Nonstop2h 12m
Multiple Airlines
Deal found 2/15$85
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:13 pm
MIA
-
CLT
Nonstop2h 26m
Frontier
Fri 4/109:44 pm
CLT
-
MIA
Nonstop2h 17m
Frontier
Deal found 2/11$86
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2710:05 am
MIA
-
CLT
Nonstop2h 15m
Spirit Airlines
Sun 3/17:00 am
CLT
-
MIA
Nonstop2h 10m
Spirit Airlines
Deal found 2/11$87

Find flight deals from Florida Keys to South Carolina

Keep the following information in mind while searching for Florida Keys to South Carolina flight deals. Data was last updated February 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$74
(Frontier)

One-way from

$37
(Super.com)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
Search Deals
From Florida Keys to South Carolina
Search Deals
One-way flight from Florida Keys to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 15, 2026.
Use the filters below to find and compare flights from Florida Keys to South Carolina that are best for you.

Fly from

Florida Keys

Fly to

South Carolina

Route

Depart

Return

Price

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 3/12

9:57 am-12:07 pm

Nonstop2h 10m

Charlotte Douglas

Sun 3/15

7:00 am-9:02 am

Nonstop2h 02m

$74

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Tue 3/10

10:05 am-12:20 pm

Nonstop2h 15m

Charlotte Douglas

Thu 3/12

7:00 am-9:02 am

Nonstop2h 02m

$74

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 3/13

7:55 am-10:12 am

Nonstop2h 17m

Charlotte Douglas

Wed 3/18

10:42 am-12:57 pm

Nonstop2h 15m

$76

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 4/24

6:13 pm-8:28 pm

Nonstop2h 15m

Charlotte Douglas

Sat 4/25

3:08 pm-5:12 pm

Nonstop2h 04m

$76

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 2/27

1:10 pm-3:30 pm

Nonstop2h 20m

Charlotte Douglas

Thu 3/5

2:21 pm-4:36 pm

Nonstop2h 15m

$77

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 4/9

9:57 am-12:07 pm

Nonstop2h 10m

Charlotte Douglas

Sun 4/12

7:00 am-9:02 am

Nonstop2h 02m

$80

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 2/27

10:05 am-12:20 pm

Nonstop2h 15m

Charlotte Douglas

Mon 3/2

7:00 am-9:10 am

Nonstop2h 10m

$87

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 2/19

3:30 pm-5:50 pm

Nonstop2h 20m

Charlotte Douglas

Fri 2/20

1:37 pm-3:53 pm

Nonstop2h 16m

$88

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 2/27

1:10 pm-3:30 pm

Nonstop2h 20m

Charlotte Douglas

Sun 3/1

2:21 pm-4:36 pm

Nonstop2h 15m

$88

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 2/27

10:05 am-12:20 pm

Nonstop2h 15m

Charlotte Douglas

Tue 3/3

7:00 am-9:10 am

Nonstop2h 10m

$93

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Showing 1-10 of 60 results
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Best time to book a flight from Florida Keys to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to South Carolina
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 15, 2026.
Peruse reviews from past customers who have flown with Delta, American Airlines, and Spirit Airlines from Florida Keys to South Carolina to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,205 reviews

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,205 reviews
Delta
7.9
Good
8,205 reviews

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,297 reviews
Delta
7.9
Good
8,205 reviews

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Spirit Airlines
6.3
Okay
8,452 reviews
Delta
7.9
Good
8,205 reviews

Crew

8.5

Entertainment

7.8

Food

7.2

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florida Keys to South Carolina?

    A quick flight from Florida Keys to South Carolina can take about 2h 10m. Spirit Airlines provides one of the quickest options available for as low as $74. Airlines will cover a distance of 652 mi. Most flights are nonstop.

  • What are the cheapest airlines to fly from Florida Keys to South Carolina one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $31. However, be on the lookout for offers from American Airlines and Breeze Airways, as they are both options that can get you from Florida Keys to South Carolina for a low price.

  • Can I find deals for flights from Florida Keys to South Carolina that include hotel bookings?

    Yes. In addition to deals on Florida Keys to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to South Carolina.

  • Can I find deals for business class flights from Florida Keys to South Carolina?

    Yes. Cheapflights offers flight deals from Florida Keys to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Florida Keys to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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