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South Carolina

$48+ Cheap flights from Florida Keys to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Florida Keys to South Carolina

Keep the following information in mind while searching for Florida Keys to South Carolina flight deals. Data was last updated September 17, 2025.

Round-trip from

$88
(Frontier)

One-way from

$48
(Kiwi.com)
From Florida Keys to South Carolina
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One-way flight from Florida Keys to South Carolina
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Find flight deals from Florida Keys to South Carolina

Cheapest flights from Florida Keys to South Carolina
Explore the most affordable flight options available from Florida Keys to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/134:21 pmMIA - CLT
Nonstop2h 13mFrontier
Mon 10/207:29 pmCLT - MIA
Nonstop2h 12mFrontier
Deal found 9/16$88
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/66:00 amMIA - CLT
Nonstop2h 11mMultiple Airlines
Sat 10/111:49 pmCLT - MIA
Nonstop2h 04mMultiple Airlines
Deal found 9/15$91
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/174:16 pmMIA - CLT
Nonstop2h 13mFrontier
Sun 10/197:24 pmCLT - MIA
Nonstop2h 12mFrontier
Deal found 9/15$93
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/103:53 pmMIA - CLT
Nonstop2h 09mFrontier
Sun 10/127:24 pmCLT - MIA
Nonstop2h 12mFrontier
Deal found 9/15$94
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:00 amMIA - CLT
Nonstop2h 11mFrontier
Sun 10/510:20 pmCLT - MIA
Nonstop2h 22mFrontier
Deal found 9/16$95
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/56:00 amMIA - CLT
Nonstop2h 11mMultiple Airlines
Sat 10/111:49 pmCLT - MIA
Nonstop2h 04mMultiple Airlines
Deal found 9/15$96
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1610:24 amMIA - CLT
Nonstop2h 15mSpirit Airlines
Sun 10/191:49 pmCLT - MIA
Nonstop2h 04mSpirit Airlines
Deal found 9/15$97
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:00 amMIA - CLT
Nonstop2h 11mMultiple Airlines
Thu 10/91:49 pmCLT - MIA
Nonstop2h 04mMultiple Airlines
Deal found 9/15$98
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/66:00 amMIA - CLT
Nonstop2h 11mMultiple Airlines
Tue 10/78:52 amCLT - MIA
1 stop9h 15mMultiple Airlines
Deal found 9/15$99
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/410:35 amMIA - CLT
Nonstop2h 10mMultiple Airlines
Sun 10/127:24 pmCLT - MIA
Nonstop2h 12mMultiple Airlines
Deal found 9/15$100
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/56:00 amMIA - CLT
Nonstop2h 11mMultiple Airlines
Thu 10/91:49 pmCLT - MIA
Nonstop2h 04mMultiple Airlines
Deal found 9/15$103
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:00 amMIA - CLT
Nonstop2h 11mFrontier
Sun 10/510:20 pmCLT - MIA
Nonstop2h 22mFrontier
Deal found 9/15$105

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Florida Keys to South Carolina that are best for you.

Fly from

Florida Keys

Fly to

South Carolina

Route

Depart

Return

Price

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 10/24

10:24 am-12:39 pm

Nonstop2h 15m

Charlotte Douglas

Thu 10/30

1:49 pm-3:53 pm

Nonstop2h 04m

$97

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Wed 12/10

1:56 pm-4:01 pm

Nonstop2h 05m

Charlotte Douglas

Wed 12/17

10:32 am-12:51 pm

Nonstop2h 19m

$97

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 10/16

10:24 am-12:39 pm

Nonstop2h 15m

Charlotte Douglas

Sun 10/19

1:49 pm-3:53 pm

Nonstop2h 04m

$97

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Mon 10/13

8:00 am-9:10 pm

1 stop13h 10m

Charlotte Douglas

Mon 10/20

7:29 pm-9:41 pm

Nonstop2h 12m

$107

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Sat 10/25

7:32 pm-7:53 am

1 stop12h 21m

Charlotte Douglas

Sun 10/26

7:24 pm-9:36 pm

Nonstop2h 12m

$116

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 10/2

10:35 am-12:45 pm

Nonstop2h 10m

Charlotte Douglas

Sat 10/4

1:50 pm-4:05 pm

Nonstop2h 15m

$117

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 11/13

7:38 pm-9:57 pm

Nonstop2h 19m

Charlotte Douglas

Sun 11/16

10:42 pm-12:54 am

Nonstop2h 12m

$118

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Tue 9/30

8:04 pm-11:36 pm

1 stop27h 32m

Charlotte Douglas

Fri 10/3

1:50 pm-4:05 pm

Nonstop2h 15m

$132

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 10/16

6:00 am-4:00 pm

1 stop10h 00m

Charlotte Douglas

Sat 10/18

1:49 pm-3:53 pm

Nonstop2h 04m

$135

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Fri 11/7

9:31 pm-8:37 am

1 stop11h 06m

Charlotte Douglas

Sun 11/9

10:32 am-12:51 pm

Nonstop2h 19m

$135

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 60 results
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Best time to book a flight from Florida Keys to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to South Carolina

What is the cheapest time of day to fly from EOA to SC?

Find hourly flight availability from Florida Keys to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 17, 2025.
Peruse reviews from past customers who have flown with Delta, American Airlines, and JetBlue from Florida Keys to South Carolina to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
JetBlue
7.2
Good
2,914 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.2
Good
699 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Spirit Airlines
6.3
Okay
8,023 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florida Keys to South Carolina?

    A quick flight from Florida Keys to South Carolina can take about 1h 43m. Spirit Airlines provides one of the quickest options available for as low as $157. Airlines will cover a distance of 490 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Florida Keys to South Carolina one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $49. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from Florida Keys to South Carolina for a low price.

  • Can I find deals for flights from Florida Keys to South Carolina that include hotel bookings?

    Yes. In addition to deals on Florida Keys to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to South Carolina.

  • Can I find deals for business class flights from Florida Keys to South Carolina?

    Yes. Cheapflights offers flight deals from Florida Keys to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Florida Keys to South Carolina (average of $217). Flying from Florida Keys to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Florida Keys to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Florida Keys to South Carolina

Discover the top 2 airlines that operate flights from Florida Keys to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$313FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$293Average$588FlexibilityNo cancel feeOn-time71%

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