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South Carolina

$44+ Cheap flights from Florida Keys to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Dec 3 — Dec 101
Wed 12/3
Wed 12/10
1 adult, Economy
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Find flight deals from Florida Keys to South Carolina

Cheapest flights from Florida Keys to South Carolina
Explore the most affordable flight options available from Florida Keys to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2025.

This Frontier deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:38 pmMIA - CLT
Nonstop2h 19mFrontier
Mon 11/1710:42 pmCLT - MIA
Nonstop2h 12mFrontier
Deal found 11/2$80
This Cheapflightsfares deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/175:45 amMIA - CLT
Nonstop2h 02mSpirit Airlines
Tue 11/187:59 pmCLT - MIA
Nonstop2h 12mSpirit Airlines
Deal found 11/2$81
This CheapOair deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:38 pmMIA - CLT
Nonstop2h 19mFrontier
Sun 11/910:42 pmCLT - MIA
Nonstop2h 12mFrontier
Deal found 10/30$82
This Kissandfly.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:45 amMIA - CLT
Nonstop2h 02mSpirit Airlines
Sun 11/169:38 pmCLT - MIA
Nonstop2h 13mSpirit Airlines
Deal found 11/1$84
This Priceline deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:56 pmMIA - CLT
Nonstop2h 14mMultiple Airlines
Tue 12/93:42 pmCLT - MIA
Nonstop2h 13mMultiple Airlines
Deal found 10/31$86
This CheapOair deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:38 pmMIA - CLT
Nonstop2h 19mFrontier
Fri 11/710:42 pmCLT - MIA
Nonstop2h 12mFrontier
Deal found 11/1$87
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/165:45 amMIA - CLT
Nonstop2h 02mMultiple Airlines
Sun 11/1610:42 pmCLT - MIA
Nonstop2h 12mMultiple Airlines
Deal found 11/2$88
This Frontier deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:55 amMIA - CLT
Nonstop2h 14mFrontier
Fri 11/2810:13 amCLT - MIA
Nonstop2h 06mFrontier
Deal found 11/2$89
This Cheapflightsfares deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:46 amMIA - CLT
Nonstop2h 03mSpirit Airlines
Wed 11/263:01 pmCLT - MIA
Nonstop2h 15mSpirit Airlines
Deal found 10/31$90
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/147:38 pmMIA - CLT
Nonstop2h 19mMultiple Airlines
Wed 11/197:59 pmCLT - MIA
Nonstop2h 12mMultiple Airlines
Deal found 11/2$91
This Cheapflightsfares deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:45 amMIA - CLT
Nonstop2h 02mSpirit Airlines
Sat 11/159:57 pmCLT - MIA
Nonstop2h 13mSpirit Airlines
Deal found 10/31$93
This Priceline deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/209:59 pmMIA - CLT
1 stop9h 55mFrontier
Tue 12/23:42 pmCLT - MIA
Nonstop2h 13mFrontier
Deal found 11/1$94

Cheap flight deals from Florida Keys to South Carolina

Keep the following information in mind while searching for Florida Keys to South Carolina flight deals. Data was last updated November 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$80
(Frontier)

One-way from

$44
(Gotogate)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
Search Deals
From Florida Keys to South Carolina
Search Deals
One-way flight from Florida Keys to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida Keys to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Florida Keys to South Carolina that are best for you.

Fly from

Florida Keys

Fly to

South Carolina

Route

Depart

Return

Price

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Mon 11/17

5:45 am-7:47 am

Nonstop2h 02m

Charlotte Douglas

Tue 11/18

7:59 pm-10:11 pm

Nonstop2h 12m

$81

MiamiCharleston

MIA - CHS

MIACHS

Miami

Thu 12/4

5:40 pm-7:23 pm

Nonstop1h 43m

Charleston

Mon 12/8

8:10 pm-10:00 pm

Nonstop1h 50m

$97

MiamiCharleston

MIA - CHS

MIACHS

Miami

Fri 12/5

11:03 pm-12:46 am

Nonstop1h 43m

Charleston

Sun 12/7

6:00 am-7:44 am

Nonstop1h 44m

$97

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Wed 12/31

1:41 pm-3:56 pm

Nonstop2h 15m

Charlotte Douglas

Thu 1/1

2:57 pm-4:59 pm

Nonstop2h 02m

$119

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Tue 11/11

10:55 am-1:00 pm

Nonstop2h 05m

Charlotte Douglas

Wed 11/19

7:59 pm-10:11 pm

Nonstop2h 12m

$119

MiamiCharleston

MIA - CHS

MIACHS

Miami

Fri 12/26

7:00 am-8:47 am

Nonstop1h 47m

Charleston

Tue 12/30

8:07 pm-10:00 pm

Nonstop1h 53m

$131

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Mon 11/24

10:45 am-9:27 pm

1 stop10h 42m

Charlotte Douglas

Fri 11/28

10:13 am-12:19 pm

Nonstop2h 06m

$133

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Wed 11/26

6:46 am-8:49 am

Nonstop2h 03m

Charlotte Douglas

Tue 12/2

5:35 am-11:46 am

1 stop6h 11m

$133

MiamiCharleston

MIA - CHS

MIACHS

Miami

Mon 12/15

7:03 am-8:45 am

Nonstop1h 42m

Charleston

Mon 12/22

8:06 pm-9:59 pm

Nonstop1h 53m

$139

MiamiCharlotte

MIA - CLT

MIACLT

Miami

Thu 11/13

7:38 pm-9:57 pm

Nonstop2h 19m

Charlotte Douglas

Sat 11/15

6:00 am-4:12 pm

1 stop10h 12m

$140

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/1

Showing 1-10 of 60 results
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Best time to book a flight from Florida Keys to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to South Carolina

What is the cheapest time of day to fly from EOA to SC?

Find hourly flight availability from Florida Keys to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 3, 2025.

It’s optimal to fly from Florida Keys to South Carolina in the afternoon. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 3, 2025.
Peruse reviews from past customers who have flown with Delta, American Airlines, and JetBlue from Florida Keys to South Carolina to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,001 reviews
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,037 reviews
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
JetBlue
7.2
Good
2,907 reviews
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Allegiant Air
7.2
Good
694 reviews
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Spirit Airlines
6.3
Okay
8,117 reviews
Delta
7.9
Good
8,001 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florida Keys to South Carolina?

    A quick flight from Florida Keys to South Carolina can take about 1h 43m. Spirit Airlines provides one of the quickest options available for as low as $97. Airlines will cover a distance of 490 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Florida Keys to South Carolina one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $44. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from Florida Keys to South Carolina for a low price.

  • Can I find deals for flights from Florida Keys to South Carolina that include hotel bookings?

    Yes. In addition to deals on Florida Keys to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to South Carolina.

  • Can I find deals for business class flights from Florida Keys to South Carolina?

    Yes. Cheapflights offers flight deals from Florida Keys to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Florida Keys to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Florida Keys to South Carolina

Discover the top 2 airlines that operate flights from Florida Keys to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$313FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$387Average$658FlexibilityNo cancel feeOn-time71%

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