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South Carolina

$55+ Cheap flights from Buffalo (BUF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated November 6, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$150
(Frontier)

One-way from

$55
(Frontier)

Popular in

April

Cheapest in

September

Average price

$363
Provider with most accurate pricing for Buffalo-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Buffalo-Myrtle Beach Intl flights.
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From Buffalo to South Carolina
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One-way flight from Buffalo to South Carolina
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Highest demand for flights based on searches. 9% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:00 amBUF - CHS
1 stop7h 05mDelta
Mon 12/85:46 pmCHS - BUF
1 stop6h 30mDelta
Deal found 11/5$200
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:00 amBUF - CHS
1 stop5h 45mDelta
Tue 12/95:00 pmCHS - BUF
1 stop6h 59mDelta
Deal found 11/5$201
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:24 pmBUF - CHS
2 stops5h 49mAmerican Airlines
Wed 12/108:05 amCHS - BUF
1 stop4h 00mAmerican Airlines
Deal found 11/5$206
This Priceline deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/411:48 amBUF - SAV
1 stop7h 50mJetBlue
Thu 12/1111:40 amSAV - BUF
1 stop5h 44mJetBlue
Deal found 11/6$207
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2011:40 amBUF - CLT
1 stop20h 59mFrontier
Mon 11/245:16 pmCLT - BUF
2 stops16h 15mFrontier
Deal found 11/4$208
This Priceline deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/289:10 amBUF - SAV
1 stop5h 14mJetBlue
Thu 12/411:38 amSAV - BUF
1 stop5h 46mJetBlue
Deal found 11/6$217
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/202:01 pmBUF - MYR
1 stop18h 43mMultiple Airlines
Mon 11/242:14 pmMYR - BUF
1 stop22h 50mMultiple Airlines
Deal found 11/5$219
This Mytrip deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2011:40 amBUF - CLT
1 stop5h 34mFrontier
Thu 11/276:09 pmCLT - BUF
1 stop20h 34mFrontier
Deal found 11/6$219
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1212:37 pmBUF - CLT
1 stop7h 23mMultiple Airlines
Sun 12/148:44 amCLT - BUF
1 stop7h 16mMultiple Airlines
Deal found 11/4$222
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1111:39 amBUF - SAV
1 stop6h 10mAmerican Airlines
Sun 12/148:24 pmSAV - BUF
1 stop3h 43mAmerican Airlines
Deal found 11/6$223
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2510:16 amBUF - CLT
2 stops12h 35mFrontier
Sun 12/710:33 pmCLT - BUF
1 stop15h 42mFrontier
Deal found 11/4$224
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/287:13 pmBUF - SAV
1 stop4h 53mAmerican Airlines
Thu 12/45:00 amSAV - BUF
2 stops7h 13mAmerican Airlines
Deal found 11/6$228

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Buffalo

Fly to

South Carolina

Route

Depart

Return

Price

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 12/5

6:25 pm-11:50 pm

1 stop5h 25m

Charleston

Mon 12/8

6:31 pm-11:59 pm

1 stop5h 28m

$200

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 12/6

1:27 pm-6:03 pm

1 stop4h 36m

Charleston

Mon 12/8

5:05 pm-11:44 pm

1 stop6h 39m

$200

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 12/6

6:00 am-1:05 pm

1 stop7h 05m

Charleston

Mon 12/8

5:46 pm-12:16 am

1 stop6h 30m

$200

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 12/3

6:00 am-10:00 am

1 stop4h 00m

Charleston

Wed 12/10

10:35 am-2:20 pm

1 stop3h 45m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Tue 12/2

12:10 pm-7:08 pm

1 stop6h 58m

Charleston

Tue 12/9

5:46 pm-12:16 am

1 stop6h 30m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Thu 1/15

11:51 am-5:13 pm

1 stop5h 22m

Charleston

Wed 1/21

12:00 pm-7:03 pm

1 stop7h 03m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sat 1/17

8:30 am-2:02 pm

1 stop5h 32m

Charleston

Tue 1/20

11:00 am-7:25 pm

2 stops8h 25m

$202

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Fri 11/28

9:10 am-2:24 pm

1 stop5h 14m

Savannah/Hilton Head

Thu 12/4

11:38 am-5:24 pm

1 stop5h 46m

$217

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Tue 2/3

6:32 pm-11:16 pm

1 stop4h 44m

Savannah/Hilton Head

Sat 2/7

7:34 am-11:58 am

1 stop4h 24m

$222

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Thu 12/4

1:50 pm-9:03 pm

1 stop7h 13m

Savannah/Hilton Head

Thu 12/11

9:50 am-2:22 pm

1 stop4h 32m

$223

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 60 results
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $164). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 14% on airfare.

What is the cheapest day to fly from Buffalo to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Buffalo to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 6, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,240 reviews

Crew

8.6

Food

7.0

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,240 reviews
Southwest
8.0
Very good
4,240 reviews

Crew

8.6

Food

7.0

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,001 reviews
Southwest
8.0
Very good
4,240 reviews

Crew

8.6

Food

7.0

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,007 reviews
Southwest
8.0
Very good
4,240 reviews

Crew

8.6

Food

7.0

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,240 reviews

Crew

8.6

Food

7.0

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
JetBlue
7.2
Good
2,907 reviews
Southwest
8.0
Very good
4,240 reviews

Crew

8.6

Food

7.0

Overall

8.0

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

  • How long is the flight from Buffalo to South Carolina?

    Airlines like Delta, American Airlines, and Southwest fly from Buffalo to South Carolina in about 4h. The time it takes to get you to your destination can typically vary by up to 1h 25m. The distance between Buffalo and South Carolina is about 697 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

    The cheapest airlines for a one-way flight from Buffalo to South Carolina are Delta ($101), Frontier ($103), and United Airlines ($112).

  • What are the most popular routes from Buffalo to South Carolina?

    While some choose either Buffalo - Myrtle Beach Intl or Buffalo - Charleston, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $164). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Buffalo to South Carolina

Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$180Average$232FlexibilityNo cancel feeOn-time62%
DeltaCheapest$196Average$303FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$198Average$344FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$234Average$376FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$251Average$412FlexibilityNo cancel feeOn-time63%

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