$67+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/2. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Mar 6 — Mar 131
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to South Carolina
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:39 pm
BUF
- CLT
1 stop6h 51m
Delta
Sun 3/18:45 am
CLT
- BUF
1 stop5h 23m
Delta
Deal found 2/3![Delta logo]()
$179
This Cheapflightsfares deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
BUF
- CHS
1 stop4h 57m
JetBlue
Wed 3/1111:48 am
CHS
- BUF
1 stop6h 47m
JetBlue
Deal found 2/2![JetBlue logo]()
$180
This Cheapflightsfares deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:00 am
BUF
- CHS
1 stop4h 57m
JetBlue
Tue 3/311:47 am
CHS
- BUF
1 stop6h 48m
JetBlue
Deal found 2/1![JetBlue logo]()
$188
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:40 pm
BUF
- SAV
1 stop4h 24m
Delta
Thu 9/38:45 am
SAV
- BUF
1 stop6h 45m
Delta
Deal found 2/3![Delta logo]()
$196
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:28 am
BUF
- CHS
1 stop4h 50m
American Airlines
Mon 3/27:03 pm
CHS
- BUF
1 stop4h 47m
American Airlines
Deal found 2/2![American Airlines logo]()
$196
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/187:00 am
SAV
- BUF
1 stop7h 52m
Delta
Deal found 2/3![Delta logo]()
$197
This Delta deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:17 pm
BUF
- CHS
1 stop4h 38m
Delta
Sat 4/256:39 pm
CHS
- BUF
1 stop4h 00m
Delta
Deal found 2/4![Delta logo]()
$197
This Justfly.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:09 pm
BUF
- CLT
1 stop16h 12m
Frontier
Sat 2/2810:16 am
CLT
- BUF
1 stop7h 29m
Frontier
Deal found 2/3![Frontier logo]()
$199
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:29 pm
BUF
- CHS
1 stop4h 19m
American Airlines
Mon 3/96:45 pm
CHS
- BUF
1 stop5h 05m
American Airlines
Deal found 2/2![American Airlines logo]()
$200
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:25 pm
BUF
- SAV
2 stops7h 33m
American Airlines
Thu 3/56:21 pm
SAV
- BUF
1 stop4h 28m
American Airlines
Deal found 2/3![American Airlines logo]()
$202
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:17 am
BUF
- CLT
1 stop5h 48m
Frontier
Thu 2/2610:24 pm
CLT
- BUF
1 stop11h 33m
Frontier
Deal found 2/3![Frontier logo]()
$202
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:23 am
BUF
- CHS
2 stops8h 09m
American Airlines
Mon 3/25:05 pm
CHS
- BUF
1 stop5h 45m
American Airlines
Deal found 2/4![American Airlines logo]()
$202
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:00 am
BUF
- CHS
1 stop4h 58m
JetBlue
Thu 3/512:36 pm
CHS
- BUF
1 stop5h 59m
JetBlue
Deal found 2/4![JetBlue logo]()
$196
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:40 pm
BUF
- SAV
1 stop4h 24m
Delta
Mon 7/277:50 pm
SAV
- BUF
1 stop4h 08m
Delta
Deal found 2/2![Delta logo]()
$197
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:41 pm
BUF
- CHS
1 stop4h 10m
American Airlines
Thu 3/56:36 pm
CHS
- BUF
1 stop4h 13m
American Airlines
Deal found 2/4![American Airlines logo]()
$197
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:07 am
BUF
- CHS
2 stops7h 45m
United Airlines
Thu 3/510:20 am
CHS
- BUF
1 stop3h 54m
United Airlines
Deal found 2/4![United Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/231:48 pm
BUF
- MYR
2 stops18h 25m
Multiple Airlines
Thu 2/2612:39 pm
MYR
- BUF
1 stop21h 18m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$261
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:50 am
BUF
- MYR
1 stop4h 25m
Southwest
Wed 3/48:15 am
MYR
- BUF
1 stop4h 15m
Southwest
Deal found 2/2![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:37 pm
BUF
- SAV
1 stop4h 22m
Delta
Tue 4/286:21 pm
SAV
- BUF
1 stop4h 18m
Delta
Deal found 2/3![Delta logo]()
$197
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:51 pm
BUF
- SAV
1 stop4h 07m
American Airlines
Thu 3/55:00 am
SAV
- BUF
2 stops7h 14m
American Airlines
Deal found 2/3![American Airlines logo]()
$202
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:04 am
BUF
- CHS
1 stop4h 09m
United Airlines
Wed 5/276:00 am
CHS
- BUF
2 stops8h 13m
United Airlines
Deal found 2/4![United Airlines logo]()
$206
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:34 pm
BUF
- SAV
1 stop4h 11m
Delta
Mon 5/187:59 pm
SAV
- BUF
1 stop4h 00m
Delta
Deal found 2/3![Delta logo]()
$197
This JetBlue deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:30 am
BUF
- SAV
1 stop5h 52m
JetBlue
Sat 3/75:20 pm
SAV
- BUF
1 stop6h 12m
JetBlue
Deal found 2/2![JetBlue logo]()
$217
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:23 am
BUF
- CHS
2 stops8h 09m
American Airlines
Mon 3/25:05 pm
CHS
- BUF
1 stop5h 45m
American Airlines
Deal found 2/4![American Airlines logo]()
$202
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:17 pm
BUF
- CHS
1 stop6h 33m
Delta
Sat 4/256:39 pm
CHS
- BUF
1 stop4h 00m
Delta
Deal found 2/3![Delta logo]()
$197
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:00 am
BUF
- SAV
1 stop4h 37m
United Airlines
Sun 7/2611:30 am
SAV
- BUF
1 stop5h 10m
United Airlines
Deal found 2/3![United Airlines logo]()
$230
This Delta deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:44 pm
BUF
- CHS
1 stop5h 11m
Delta
Tue 4/286:00 am
CHS
- BUF
1 stop5h 06m
Delta
Deal found 2/4![Delta logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:25 am
BUF
- CLT
1 stop6h 58m
Multiple Airlines
Sun 4/267:18 pm
CLT
- BUF
2 stops16h 55m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$267
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:55 pm
BUF
- CHS
1 stop6h 01m
Delta
Sat 5/306:38 pm
CHS
- BUF
1 stop5h 21m
Delta
Deal found 2/2![Delta logo]()
$197
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/284:45 pm
BUF
- MYR
1 stop4h 35m
Southwest
Tue 3/311:05 am
MYR
- BUF
2 stops10h 50m
Southwest
Deal found 2/2![Southwest logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:08 pm
BUF
- CLT
2 stops31h 25m
Multiple Airlines
Wed 4/298:05 pm
CLT
- BUF
1 stop23h 08m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$286
This Delta deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:34 pm
BUF
- CHS
1 stop4h 35m
Delta
Wed 5/276:15 am
CHS
- BUF
1 stop4h 48m
Delta
Deal found 2/4![Delta logo]()
$197
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/275:29 pm
BUF
- CAE
1 stop6h 23m
American Airlines
Mon 3/26:48 am
CAE
- BUF
1 stop5h 26m
American Airlines
Deal found 2/4![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:50 am
BUF
- CLT
1 stop6h 33m
United Airlines
Tue 4/286:25 pm
CLT
- BUF
1 stop5h 08m
United Airlines
Deal found 2/3![United Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/127:38 pm
BUF
- CHS
1 stop4h 38m
Delta
Mon 3/166:58 pm
CHS
- BUF
1 stop4h 15m
Delta
Deal found 2/3![Delta logo]()
$197
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/281:21 pm
BUF
- SAV
1 stop5h 41m
Delta
Thu 3/56:44 am
SAV
- BUF
1 stop4h 16m
Delta
Deal found 2/2![Delta logo]()
$203
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:23 am
BUF
- CAE
1 stop6h 27m
American Airlines
Sun 3/87:00 am
CAE
- BUF
1 stop3h 58m
American Airlines
Deal found 2/3![American Airlines logo]()
$304
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:07 am
BUF
- CAE
2 stops7h 57m
United Airlines
Mon 3/97:39 pm
CAE
- BUF
1 stop4h 03m
United Airlines
Deal found 2/2![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/318:55 am
BUF
- HHH
1 stop6h 06m
American Airlines
Mon 4/66:15 pm
HHH
- BUF
1 stop5h 13m
American Airlines
Deal found 2/4![American Airlines logo]()
$308
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:45 pm
BUF
- CLT
1 stop4h 12m
United Airlines
Tue 4/286:25 pm
CLT
- BUF
1 stop5h 08m
United Airlines
Deal found 2/3![United Airlines logo]()
$309
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:45 pm
BUF
- CLT
1 stop4h 12m
United Airlines
Mon 4/277:40 pm
CLT
- BUF
1 stop4h 10m
United Airlines
Deal found 2/3![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:37 pm
BUF
- SAV
1 stop4h 22m
Delta
Tue 4/286:21 pm
SAV
- BUF
1 stop4h 18m
Delta
Deal found 2/3![Delta logo]()
$238
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated February 4, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated February 4, 2026 and is based on user searches.
This Justfly.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:09 pm
BUF
- CLT
1 stop16h 12m
Frontier
Sat 2/2810:16 am
CLT
- BUF
1 stop7h 29m
Frontier
Deal found 2/3![Frontier logo]()
$199
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:28 am
BUF
- CHS
1 stop4h 50m
American Airlines
Mon 3/27:03 pm
CHS
- BUF
1 stop4h 47m
American Airlines
Deal found 2/2![American Airlines logo]()
$196
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:17 am
BUF
- CLT
1 stop5h 48m
Frontier
Thu 2/2610:24 pm
CLT
- BUF
1 stop11h 33m
Frontier
Deal found 2/3![Frontier logo]()
$202
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:39 pm
BUF
- CLT
1 stop6h 51m
Delta
Sun 3/18:45 am
CLT
- BUF
1 stop5h 23m
Delta
Deal found 2/3![Delta logo]()
$179
This JetBlue deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2810:25 am
BUF
- SAV
1 stop5h 57m
JetBlue
Thu 3/55:21 pm
SAV
- BUF
1 stop6h 11m
JetBlue
Deal found 2/1![JetBlue logo]()
$181
This Cheapflightsfares deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:00 am
BUF
- CHS
1 stop4h 57m
JetBlue
Tue 3/311:47 am
CHS
- BUF
1 stop6h 48m
JetBlue
Deal found 2/1![JetBlue logo]()
$188
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:02 pm
BUF
- SAV
1 stop4h 56m
American Airlines
Thu 3/56:21 pm
SAV
- BUF
1 stop4h 28m
American Airlines
Deal found 2/3![American Airlines logo]()
$197
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:17 pm
BUF
- CHS
1 stop4h 01m
American Airlines
Mon 3/27:03 pm
CHS
- BUF
1 stop4h 47m
American Airlines
Deal found 2/4![American Airlines logo]()
$197
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:25 pm
BUF
- SAV
1 stop5h 01m
United Airlines
Thu 3/57:20 pm
SAV
- BUF
1 stop4h 22m
United Airlines
Deal found 2/3![United Airlines logo]()
$203
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:29 pm
BUF
- CHS
1 stop4h 19m
American Airlines
Mon 3/96:45 pm
CHS
- BUF
1 stop5h 05m
American Airlines
Deal found 2/2![American Airlines logo]()
$200
This Cheapflightsfares deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
BUF
- CHS
1 stop4h 57m
JetBlue
Wed 3/1111:48 am
CHS
- BUF
1 stop6h 47m
JetBlue
Deal found 2/2![JetBlue logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:25 pm
BUF
- CLT
1 stop10h 38m
Multiple Airlines
Sat 3/143:12 pm
CLT
- BUF
2 stops43h 52m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$203
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:37 am
BUF
- CLT
1 stop26h 14m
Frontier
Deal found 2/2![Frontier logo]()
$67
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2010:42 am
BUF
- CLT
1 stop21h 51m
Frontier
Deal found 2/3![Frontier logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/110:47 am
BUF
- CLT
1 stop20h 02m
Frontier
Deal found 2/3![Frontier logo]()
$85
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:25 am
BUF
- CLT
1 stop29h 10m
Frontier
Deal found 2/2![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/214:37 pm
BUF
- CAE
1 stop22h 21m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$96
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/251:35 pm
BUF
- SAV
1 stop6h 22m
Delta
Deal found 2/3![Delta logo]()
$99
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2811:23 am
BUF
- CHS
1 stop6h 34m
American Airlines
Deal found 2/3![American Airlines logo]()
$99
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:00 am
BUF
- CHS
1 stop6h 55m
United Airlines
Deal found 2/3![United Airlines logo]()
$101
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:45 pm
BUF
- SAV
1 stop4h 14m
United Airlines
Deal found 2/1![United Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:25 am
BUF
- CLT
1 stop22h 52m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/201:29 pm
BUF
- CLT
2 stops10h 27m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$109
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/184:04 pm
BUF
- CHS
1 stop4h 42m
American Airlines
Deal found 2/1![American Airlines logo]()
$109
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated February 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $179 (Delta) |
One-way from | $67 (Kiwi.com) |
Popular in | April |
Cheapest in | September |
Average price | $346 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Buffalo
Fly to
South Carolina
Route
Depart
Return
Price
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sun 3/1
6:00 am-10:58 am
1 stop4h 58m
Charleston
Thu 3/5
12:36 pm-6:35 pm
1 stop5h 59m
$196
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Fri 7/24
7:40 pm-12:04 am
1 stop4h 24m
Savannah/Hilton Head
Mon 7/27
7:50 pm-11:58 pm
1 stop4h 08m
$197
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sun 3/1
7:41 pm-11:51 pm
1 stop4h 10m
Charleston
Thu 3/5
6:36 pm-10:49 pm
1 stop4h 13m
$197
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Fri 4/24
7:37 pm-11:59 pm
1 stop4h 22m
Savannah/Hilton Head
Tue 4/28
6:21 pm-10:39 pm
1 stop4h 18m
$197
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Wed 5/13
7:34 pm-11:45 pm
1 stop4h 11m
Savannah/Hilton Head
Mon 5/18
7:59 pm-11:59 pm
1 stop4h 00m
$197
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 4/18
5:17 pm-11:50 pm
1 stop6h 33m
Charleston
Sat 4/25
6:39 pm-10:39 pm
1 stop4h 00m
$197
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 4/24
4:44 pm-9:55 pm
1 stop5h 11m
Charleston
Tue 4/28
6:00 am-11:06 am
1 stop5h 06m
$197
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 5/23
4:55 pm-10:56 pm
1 stop6h 01m
Charleston
Sat 5/30
6:38 pm-11:59 pm
1 stop5h 21m
$197
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Wed 5/20
7:34 pm-12:09 am
1 stop4h 35m
Charleston
Wed 5/27
6:15 am-11:03 am
1 stop4h 48m
$197
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Thu 3/12
7:38 pm-12:16 am
1 stop4h 38m
Charleston
Mon 3/16
6:58 pm-11:13 pm
1 stop4h 15m
$197
Showing 1-10 of 60 results
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-CHS
BUF-SAV
BUF-MYR
BUF-CLT
BUF-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-CHS
BUF-SAV
BUF-MYR
BUF-CLT
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $120). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from BUF to SC?
Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.
One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 46% on airfare.
What is the cheapest day to fly from Buffalo to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 4, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Entertainment
7.5
Food
7.0
Crew
8.6
Boarding
8.1
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on February 4, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$114 | Average$307 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$337 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$367 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$251 | Average$392 | FlexibilityNo cancel fee | On-time63% |