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South Carolina

$80+ Cheap flights from Buffalo (BUF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/17. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$196
(Flysmarter)

One-way from

$80
(Kiwi.com)

Popular in

April

Cheapest in

September

Average price

$344
Provider with most accurate pricing for Buffalo-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Buffalo-Myrtle Beach Intl flights.
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From Buffalo to South Carolina
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One-way flight from Buffalo to South Carolina
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Highest demand for flights based on searches. 9% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1011:21 amBUF - CHS
1 stop5h 45mDelta
Sat 12/136:00 amCHS - BUF
1 stop5h 05mDelta
Deal found 10/15$199
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:35 pmBUF - CHS
1 stop4h 38mAmerican Airlines
Mon 12/228:08 pmCHS - BUF
1 stop3h 51mAmerican Airlines
Deal found 10/15$200
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:20 amBUF - CHS
1 stop5h 18mAmerican Airlines
Thu 11/207:53 pmCHS - BUF
1 stop4h 15mAmerican Airlines
Deal found 10/15$201
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:24 pmBUF - CHS
2 stops5h 49mAmerican Airlines
Sat 12/1312:58 pmCHS - BUF
1 stop5h 29mAmerican Airlines
Deal found 10/15$204
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:24 pmBUF - CHS
2 stops5h 49mAmerican Airlines
Mon 12/156:09 amCHS - BUF
1 stop5h 56mAmerican Airlines
Deal found 10/15$206
This JetBlue deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:05 amBUF - SAV
1 stop4h 59mJetBlue
Sat 12/1312:17 pmSAV - BUF
1 stop5h 07mJetBlue
Deal found 10/16$207
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:35 pmBUF - CHS
1 stop6h 28mDelta
Sat 11/86:00 amCHS - BUF
1 stop4h 31mDelta
Deal found 10/16$209
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/96:10 amBUF - CHS
1 stop7h 15mDelta
Thu 11/136:00 amCHS - BUF
1 stop4h 37mDelta
Deal found 10/14$217
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1312:15 pmBUF - CHS
2 stops8h 53mUnited Airlines
Thu 11/2010:00 amCHS - BUF
1 stop4h 20mUnited Airlines
Deal found 10/14$222
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/116:25 pmBUF - SAV
1 stop5h 34mDelta
Sun 12/146:41 amSAV - BUF
1 stop4h 24mDelta
Deal found 10/16$223
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:03 amBUF - SAV
1 stop5h 39mAmerican Airlines
Sun 12/145:00 amSAV - BUF
2 stops7h 00mAmerican Airlines
Deal found 10/15$228
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:12 pmBUF - MYR
2 stops21h 59mMultiple Airlines
Sat 11/86:15 amMYR - BUF
1 stop12h 02mMultiple Airlines
Deal found 10/15$233

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Buffalo

Fly to

South Carolina

Route

Depart

Return

Price

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Mon 12/1

2:34 pm-10:37 pm

1 stop8h 03m

Charleston

Mon 12/8

6:35 am-11:33 am

1 stop4h 58m

$196

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Wed 12/10

11:21 am-5:06 pm

1 stop5h 45m

Charleston

Sat 12/13

6:00 am-11:05 am

1 stop5h 05m

$199

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Mon 12/15

6:35 pm-11:13 pm

1 stop4h 38m

Charleston

Mon 12/22

8:08 pm-11:59 pm

1 stop3h 51m

$200

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Thu 11/13

11:26 am-4:27 pm

1 stop5h 01m

Charleston

Sun 11/16

6:00 am-11:07 am

1 stop5h 07m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Mon 3/23

9:15 am-5:22 pm

1 stop8h 07m

Charleston

Fri 3/27

12:05 pm-8:21 pm

1 stop8h 16m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sun 1/11

7:00 am-11:52 am

1 stop4h 52m

Charleston

Sat 1/17

7:00 am-12:03 pm

1 stop5h 03m

$201

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Sun 1/11

7:00 am-11:34 am

1 stop4h 34m

Charleston

Sat 1/17

6:10 am-3:28 pm

2 stops9h 18m

$206

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

Fri 12/12

5:24 pm-11:13 pm

2 stops5h 49m

Charleston

Mon 12/15

6:09 am-12:05 pm

1 stop5h 56m

$206

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Sun 12/7

6:05 am-11:32 am

1 stop5h 27m

Savannah/Hilton Head

Tue 12/9

12:17 pm-5:24 pm

1 stop5h 07m

$207

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

Fri 12/5

7:05 am-12:04 pm

1 stop4h 59m

Savannah/Hilton Head

Sat 12/13

12:17 pm-5:24 pm

1 stop5h 07m

$207

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 60 results
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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $159). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 14% on airfare.

What is the cheapest day to fly from Buffalo to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 16, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,984 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,982 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,043 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
JetBlue
7.2
Good
2,908 reviews
Southwest
8.0
Very good
4,241 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South Carolina?

    Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

  • How long is the flight from Buffalo to South Carolina?

    Airlines like JetBlue, Delta, and American Airlines fly from Buffalo to South Carolina in about 4h 38m. The time it takes to get you to your destination can typically vary by up to 3h 25m. The distance between Buffalo and South Carolina is about 697 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

    The cheapest airlines for a one-way flight from Buffalo to South Carolina are Frontier ($80), JetBlue ($81), and Delta ($101).

  • What are the most popular routes from Buffalo to South Carolina?

    While some choose either Buffalo - Myrtle Beach Intl or Buffalo - Savannah/Hilton Head, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.

  • Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

    Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

  • Can I find deals for business class flights from Buffalo to South Carolina?

    Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South Carolina?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $159). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Buffalo to South Carolina

Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$80Average$232FlexibilityNo cancel feeOn-time62%
DeltaCheapest$196Average$307FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$198Average$352FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$218Average$404FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$234Average$408FlexibilityNo cancel feeOn-time69%

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