How long is the flight from Buffalo to South Carolina?

Airlines like Southwest, American Airlines, and Frontier fly from Buffalo to South Carolina in about 6h 48m. The time it takes to get you to your destination can typically vary by up to 5h 09m. The distance between Buffalo and South Carolina is about 759 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from Buffalo to South Carolina one-way?

The cheapest airlines for a one-way flight from Buffalo to South Carolina are American Airlines ($99), JetBlue ($100), and Delta ($113).

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

What are the most popular routes from Buffalo to South Carolina?

While some choose either Buffalo - Myrtle Beach Intl or Buffalo - Savannah/Hilton Head, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.

What are the most popular airlines that fly from Buffalo to South Carolina?

Consider American Airlines, Southwest or Delta when booking your flight. These represent the most popular airlines when flying from Buffalo to South Carolina.

What airport do you fly from for flights from Buffalo to South Carolina?

Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?

Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Buffalo to South Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.

Can I find deals for business class flights from Buffalo to South Carolina?

Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$75+ Flights from Buffalo to South Carolina

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Cheap flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on décembre 4, 2025.

sam. 12/206:00 amBUF - SAV

1 stop5h 38mAmerican Airlines

jeu. 12/2512:00 pmSAV - BUF

1 stop4h 18mAmerican Airlines

Deal found 12/3

$217

mar. 12/237:58 pmBUF - CLT

1 stop19h 18mFrontier

mer. 12/312:51 pmCLT - BUF

1 stop22h 21mFrontier

Deal found 12/2

$217

mer. 12/1712:57 pmBUF - SAV

1 stop3h 51mAmerican Airlines

dim. 12/216:40 amSAV - BUF

1 stop4h 27mAmerican Airlines

Deal found 12/2

$231

mar. 12/236:32 pmBUF - CLT

2 stops20h 44mMultiple Airlines

mer. 1/79:34 pmCLT - BUF

1 stop10h 39mMultiple Airlines

Deal found 12/2

$245

mar. 12/237:15 pmBUF - CHS

1 stop4h 50mAmerican Airlines

mar. 12/308:08 pmCHS - BUF

1 stop3h 51mAmerican Airlines

Deal found 12/2

$246

jeu. 12/182:07 pmBUF - CLT

1 stop23h 49mMultiple Airlines

mer. 1/79:34 pmCLT - BUF

1 stop10h 39mMultiple Airlines

Deal found 12/2

$247

mar. 12/236:32 pmBUF - CLT

2 stops20h 44mMultiple Airlines

ven. 1/306:01 pmCLT - BUF

1 stop17h 33mMultiple Airlines

Deal found 12/2

$257

dim. 12/217:58 pmBUF - CLT

2 stops18h 14mMultiple Airlines

mer. 1/79:34 pmCLT - BUF

1 stop10h 39mMultiple Airlines

Deal found 12/2

$260

mer. 12/3111:08 amBUF - CLT

1 stop9h 01mFrontier

mer. 1/74:32 pmCLT - BUF

1 stop15h 41mFrontier

Deal found 12/2

$266

dim. 12/217:58 pmBUF - CLT

1 stop21h 03mFrontier

jeu. 1/296:54 pmCLT - BUF

1 stop23h 42mFrontier

Deal found 12/2

$269

jeu. 12/182:07 pmBUF - CLT

1 stop23h 49mFrontier

dim. 12/219:33 pmCLT - BUF

1 stop23h 35mFrontier

Deal found 12/1

$270

dim. 12/217:58 pmBUF - CLT

2 stops18h 14mMultiple Airlines

ven. 1/3011:12 amCLT - BUF

1 stop7h 24mMultiple Airlines

Deal found 12/2

$272

Best flights from Buffalo to South Carolina
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated décembre 4, 2025.

mar. 2/106:20 amBUF - SAV

1 stop10h 30mSouthwest

mer. 2/186:05 amSAV - BUF

1 stop10h 10mSouthwest

Deal found 12/2

$150

mar. 2/36:00 amBUF - SAV

1 stop6h 48mAmerican Airlines

sam. 2/77:00 amSAV - BUF

1 stop5h 08mAmerican Airlines

Deal found 12/3

$159

mer. 4/2212:50 pmBUF - SAV

1 stop6h 09mJetBlue

mar. 4/2810:54 amSAV - BUF

1 stop7h 33mJetBlue

Deal found 12/2

$189

sam. 1/178:06 pmBUF - CLT

1 stop11h 57mFrontier

sam. 1/249:59 pmCLT - BUF

1 stop12h 08mFrontier

Deal found 12/4

$189

jeu. 2/59:55 amBUF - CHS

1 stop4h 53mUnited Airlines

dim. 2/86:05 amCHS - BUF

2 stops8h 09mUnited Airlines

Deal found 12/1

$196

mar. 1/132:10 pmBUF - CHS

1 stop6h 45mDelta

ven. 1/1611:39 amCHS - BUF

1 stop5h 20mDelta

Deal found 12/3

$197

jeu. 2/197:32 pmBUF - CHS

1 stop4h 27mAmerican Airlines

mar. 2/245:22 amCHS - BUF

1 stop6h 26mAmerican Airlines

Deal found 12/4

$159

ven. 1/29:57 amBUF - CLT

1 stop10h 12mMultiple Airlines

mar. 1/69:38 pmCLT - BUF

2 stops34h 35mMultiple Airlines

Deal found 12/4

$324

dim. 2/88:45 amBUF - CHS

1 stop7h 05mSouthwest

mer. 2/187:55 amCHS - BUF

2 stops8h 20mSouthwest

Deal found 12/2

$183

lun. 1/196:53 pmBUF - SAV

1 stop4h 23mAmerican Airlines

ven. 1/236:00 amSAV - BUF

1 stop5h 21mAmerican Airlines

Deal found 12/3

$170

mar. 3/36:00 amBUF - CHS

1 stop4h 57mJetBlue

mar. 3/1011:47 amCHS - BUF

1 stop6h 47mJetBlue

Deal found 12/1

$197

jeu. 1/156:00 amBUF - CHS

1 stop5h 48mDelta

ven. 1/1611:39 amCHS - BUF

1 stop5h 20mDelta

Deal found 12/3

$197

sam. 2/73:35 pmBUF - SAV

1 stop4h 35mSouthwest

dim. 2/86:05 amSAV - BUF

1 stop10h 10mSouthwest

Deal found 12/2

$186

ven. 2/205:19 amBUF - CHS

1 stop4h 56mAmerican Airlines

lun. 2/235:06 pmCHS - BUF

1 stop5h 31mAmerican Airlines

Deal found 12/1

$170

ven. 1/166:26 pmBUF - CHS

1 stop5h 29mDelta

dim. 1/186:30 amCHS - BUF

1 stop6h 29mDelta

Deal found 12/3

$199

sam. 1/172:49 pmBUF - GSP

2 stops8h 59mUnited Airlines

jeu. 1/226:35 amGSP - BUF

1 stop6h 49mUnited Airlines

Deal found 12/3

$228

mar. 1/135:12 amBUF - MYR

1 stop6h 32mAmerican Airlines

mar. 1/208:00 amMYR - BUF

1 stop4h 08mAmerican Airlines

Deal found 12/2

$173

mer. 1/145:50 amBUF - MYR

1 stop4h 25mSouthwest

sam. 1/177:40 amMYR - BUF

1 stop4h 20mSouthwest

Deal found 12/3

$198

mar. 3/311:51 amBUF - CHS

1 stop5h 19mDelta

lun. 3/96:00 amCHS - BUF

1 stop4h 57mDelta

Deal found 12/1

$199

mer. 1/147:00 amBUF - MYR

1 stop6h 23mAmerican Airlines

mer. 1/217:19 pmMYR - BUF

1 stop4h 22mAmerican Airlines

Deal found 12/3

$173

sam. 1/173:35 pmBUF - MYR

1 stop4h 00mSouthwest

mer. 1/218:15 amMYR - BUF

1 stop4h 15mSouthwest

Deal found 12/3

$198

dim. 2/86:03 amBUF - CHS

1 stop5h 06mDelta

jeu. 2/195:55 pmCHS - BUF

1 stop6h 03mDelta

Deal found 12/2

$199

jeu. 1/158:30 amBUF - CAE

1 stop5h 30mUnited Airlines

mar. 1/202:37 pmCAE - BUF

1 stop5h 52mUnited Airlines

Deal found 12/2

$249

ven. 1/96:00 amBUF - SAV

1 stop6h 48mAmerican Airlines

mar. 1/136:15 amSAV - BUF

2 stops5h 53mAmerican Airlines

Deal found 12/3

$175

mer. 3/46:00 amBUF - CHS

1 stop4h 57mDelta

sam. 3/711:39 amCHS - BUF

1 stop5h 20mDelta

Deal found 12/1

$199

mar. 2/1011:50 amBUF - MYR

2 stops9h 04mAmerican Airlines

mar. 2/176:01 amMYR - BUF

1 stop6h 49mAmerican Airlines

Deal found 12/3

$178

ven. 12/1212:37 pmBUF - CLT

1 stop9h 01mFrontier

lun. 12/292:51 pmCLT - BUF

1 stop6h 17mFrontier

Deal found 12/3

$317

sam. 1/312:49 pmBUF - GSP

1 stop4h 40mUnited Airlines

mer. 2/410:00 amGSP - BUF

1 stop4h 14mUnited Airlines

Deal found 12/2

$280

mar. 1/136:03 amBUF - MYR

2 stops9h 08mDelta

mar. 1/204:07 pmMYR - BUF

1 stop7h 21mDelta

Deal found 12/3

$215

mar. 1/67:00 amBUF - MYR

1 stop6h 23mAmerican Airlines

mer. 1/78:00 amMYR - BUF

2 stops7h 17mAmerican Airlines

Deal found 12/4

$178

Last-minute flights from Buffalo to South Carolina
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated décembre 4, 2025 and is based on user searches.

mar. 1/62:56 pmBUF - CHS

1 stop6h 10mDelta

jeu. 1/811:28 amCHS - BUF

1 stop5h 27mDelta

Deal found 12/2

$197

jeu. 1/86:00 amBUF - CHS

1 stop5h 34mAmerican Airlines

lun. 1/124:35 pmCHS - BUF

1 stop7h 07mAmerican Airlines

Deal found 12/2

$159

ven. 1/911:50 amBUF - SAV

1 stop4h 45mAmerican Airlines

mar. 1/137:10 pmSAV - BUF

1 stop4h 31mAmerican Airlines

Deal found 12/3

$170

mar. 1/135:12 amBUF - MYR

1 stop6h 32mAmerican Airlines

mar. 1/208:00 amMYR - BUF

1 stop4h 08mAmerican Airlines

Deal found 12/2

$173

mar. 1/135:50 amBUF - MYR

1 stop4h 25mSouthwest

mar. 1/208:15 amMYR - BUF

1 stop4h 15mSouthwest

Deal found 12/1

$174

mer. 1/145:50 amBUF - MYR

1 stop4h 25mSouthwest

sam. 1/177:40 amMYR - BUF

1 stop4h 20mSouthwest

Deal found 12/3

$198

jeu. 1/156:53 pmBUF - CHS

1 stop4h 14mAmerican Airlines

dim. 1/186:10 amCHS - BUF

1 stop5h 58mAmerican Airlines

Deal found 12/3

$180

sam. 1/178:06 pmBUF - CLT

1 stop11h 57mFrontier

sam. 1/249:59 pmCLT - BUF

1 stop12h 08mFrontier

Deal found 12/4

$189

sam. 1/177:00 amBUF - SAV

1 stop4h 48mDelta

sam. 1/248:00 amSAV - BUF

1 stop4h 38mDelta

Deal found 12/3

$197

sam. 1/2412:29 pmBUF - CLT

1 stop21h 01mFrontier

sam. 2/79:59 pmCLT - BUF

1 stop12h 08mFrontier

Deal found 12/3

$193

mar. 1/2711:50 amBUF - MYR

2 stops9h 04mAmerican Airlines

mar. 2/35:29 pmMYR - BUF

1 stop6h 12mAmerican Airlines

Deal found 12/1

$178

jeu. 1/296:53 pmBUF - SAV

1 stop4h 23mAmerican Airlines

dim. 2/16:00 amSAV - BUF

1 stop5h 21mAmerican Airlines

Deal found 12/2

$181

One-way flights from Buffalo to South Carolina
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated décembre 4, 2025.

lun. 2/27:31 pmBUF - CLT

1 stop21h 23mMultiple Airlines

Deal found 12/4

$75

mar. 3/36:08 pmBUF - CLT

1 stop15h 47mFrontier

Deal found 12/4

$79

mar. 1/65:12 amBUF - CHS

1 stop5h 20mAmerican Airlines

Deal found 12/2

$80

mar. 2/35:50 amBUF - CLT

1 stop4h 30mSouthwest

Deal found 12/4

$81

lun. 3/29:57 amBUF - CLT

1 stop11h 09mFrontier

Deal found 12/2

$87

lun. 2/27:31 pmBUF - CLT

1 stop15h 09mFrontier

Deal found 12/3

$91

jeu. 1/297:59 pmBUF - CLT

1 stop14h 18mMultiple Airlines

Deal found 12/2

$93

lun. 1/57:15 pmBUF - CHS

1 stop4h 50mAmerican Airlines

Deal found 12/3

$101

ven. 2/67:31 pmBUF - CLT

1 stop21h 23mMultiple Airlines

Deal found 12/4

$103

sam. 1/178:06 pmBUF - CLT

1 stop11h 57mFrontier

Deal found 12/2

$104

dim. 12/143:18 pmBUF - CLT

1 stop6h 20mFrontier

Deal found 12/3

$106

dim. 3/19:57 amBUF - CLT

1 stop22h 00mFrontier

Deal found 12/4

$108

Find flight deals from Buffalo to South Carolina

Most accurate provider	Mytrip 3 stars
Most trusted provider	Mytrip 3 stars
Round-trip from	$159 (American Airlines)
One-way from	$75 (Kiwi.com)
Popular in	April
Cheapest in	October
Average price	$386

Provider with most accurate pricing for Buffalo-Myrtle Beach Intl flight deals.

Search Deals

Provider most trusted by Cheapflights users for Buffalo-Myrtle Beach Intl flights.

Search Deals

From Buffalo to South Carolina

Search Deals

One-way flight from Buffalo to South Carolina

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($43 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

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Cheapflights Fare Finder

Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

mar. 2/10

6:20 am-4:50 pm

1 stop10h 30m

Savannah/Hilton Head

mer. 2/18

6:05 am-4:15 pm

1 stop10h 10m

$150

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

mar. 2/3

6:00 am-12:48 pm

1 stop6h 48m

Savannah/Hilton Head

sam. 2/7

7:00 am-12:08 pm

1 stop5h 08m

$159

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

jeu. 2/19

7:32 pm-11:59 pm

1 stop4h 27m

Charleston

mar. 2/24

5:22 am-11:48 am

1 stop6h 26m

$159

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

lun. 1/19

6:53 pm-11:16 pm

1 stop4h 23m

Savannah/Hilton Head

ven. 1/23

6:00 am-11:21 am

1 stop5h 21m

$170

BuffaloCharleston

BUF - CHS

BUFCHS

Buffalo

ven. 2/20

5:19 am-10:15 am

1 stop4h 56m

Charleston

lun. 2/23

5:06 pm-10:37 pm

1 stop5h 31m

$170

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

mar. 1/13

5:12 am-11:44 am

1 stop6h 32m

Myrtle Beach Intl

mar. 1/20

8:00 am-12:08 pm

1 stop4h 08m

$173

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

mer. 1/14

7:00 am-1:23 pm

1 stop6h 23m

Myrtle Beach Intl

mer. 1/21

7:19 pm-11:41 pm

1 stop4h 22m

$173

BuffaloSavannah

BUF - SAV

BUFSAV

Buffalo

ven. 1/9

6:00 am-12:48 pm

1 stop6h 48m

Savannah/Hilton Head

mar. 1/13

6:15 am-12:08 pm

2 stops5h 53m

$175

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

mar. 2/10

11:50 am-8:54 pm

2 stops9h 04m

Myrtle Beach Intl

mar. 2/17

6:01 am-12:50 pm

1 stop6h 49m

$178

BuffaloMyrtle Beach

BUF - MYR

BUFMYR

Buffalo

mar. 1/6

7:00 am-1:23 pm

1 stop6h 23m

Myrtle Beach Intl

mer. 1/7

8:00 am-3:17 pm

2 stops7h 17m

$178

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 60 results

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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $132). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from BUF to SC?

One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 14% on airfare.

What is the cheapest day to fly from Buffalo to South Carolina?

Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

8.0

Very good

4,250 reviews

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Delta

7.9

Good

8,011 reviews

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

United Airlines

7.4

Good

9,066 reviews

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,047 reviews

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

JetBlue

7.2

Good

2,899 reviews

Southwest

8.0

Very good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

What airport do you fly from for flights from Buffalo to South Carolina?
Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South Carolina. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.
How long is the flight from Buffalo to South Carolina?
Airlines like Southwest, American Airlines, and Frontier fly from Buffalo to South Carolina in about 6h 48m. The time it takes to get you to your destination can typically vary by up to 5h 09m. The distance between Buffalo and South Carolina is about 759 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from Buffalo to South Carolina one-way?
The cheapest airlines for a one-way flight from Buffalo to South Carolina are American Airlines ($99), JetBlue ($100), and Delta ($113).
What are the most popular routes from Buffalo to South Carolina?
While some choose either Buffalo - Myrtle Beach Intl or Buffalo - Savannah/Hilton Head, Buffalo - Charlotte Douglas is the most popular route from Buffalo to South Carolina.
Can I find deals for flights from Buffalo to South Carolina that include hotel bookings?
Yes. In addition to deals on Buffalo to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Buffalo to South Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South Carolina.
Can I find deals for business class flights from Buffalo to South Carolina?
Yes. Cheapflights offers flight deals from Buffalo to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $132). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

South Carolina car rentals

Charleston Airport car rentals

Myrtle Beach Intl Airport car rentals

Greenville Airport car rentals

Columbia Metropolitan Airport car rentals

Hilton Head Island Airport car rentals

Florence Airport car rentals

Myrtle Beach car rentals

Columbia car rentals

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Florence car rentals

Top 5 airlines flying from Buffalo to South Carolina

Airline	Cheapest	Average	Flexibility	On-time
JetBlue	Cheapest$180	Average$232	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$196	Average$304	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$198	Average$339	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$234	Average$385	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$251	Average$406	FlexibilityNo cancel fee	On-time63%

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$75+ Cheap flights from Buffalo (BUF) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Buffalo to South Carolina

Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on décembre 4, 2025.

Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on décembre 4, 2025.

Find flight deals from Buffalo to South Carolina

Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated décembre 4, 2025.

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Best time to book a flight from Buffalo to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.

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Everything you need to know about your flight from Buffalo to South Carolina

What is the cheapest month to book a flight from Buffalo to South Carolina?

What is the cheapest time of day to fly from BUF to SC?

Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated décembre 4, 2025.

What is the cheapest day to fly from Buffalo to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on December 16, 2024.

Reviews of airlines servicing South Carolina

Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

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Alternative routes for Buffalo to South Carolina

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Top 5 airlines flying from Buffalo to South Carolina

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Cheapest flights from Buffalo to South Carolina
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on décembre 4, 2025.