$76+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
May 9 — May 161
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:49 pm
BUF
- CHS
2 stops29h 11m
Multiple Airlines
Tue 6/210:38 am
CHS
- BUF
1 stop8h 21m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:19 am
BUF
- GSP
1 stop8h 19m
Multiple Airlines
Fri 5/18:18 pm
GSP
- BUF
2 stops15h 55m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- CHS
1 stop13h 46m
Multiple Airlines
Thu 5/282:53 pm
CHS
- BUF
1 stop28h 06m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$240
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:05 pm
BUF
- SAV
1 stop4h 25m
Southwest
Tue 6/97:50 am
SAV
- BUF
1 stop6h 30m
Southwest
Deal found 4/5![Southwest logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/34:07 pm
BUF
- MYR
1 stop17h 53m
Multiple Airlines
Sun 5/109:50 pm
MYR
- BUF
2 stops36h 51m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- MYR
1 stop13h 13m
Multiple Airlines
Sun 5/313:53 pm
MYR
- BUF
2 stops42h 48m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$251
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:35 pm
BUF
- SAV
1 stop6h 22m
Delta
Fri 5/85:05 pm
SAV
- BUF
1 stop6h 54m
Delta
Deal found 4/4![Delta logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:32 pm
BUF
- CHS
2 stops20h 06m
Multiple Airlines
Fri 4/243:21 pm
CHS
- BUF
1 stop19h 28m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$253
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 pm
BUF
- SAV
1 stop4h 05m
Southwest
Fri 5/82:05 pm
SAV
- BUF
2 stops8h 40m
Southwest
Deal found 4/4![Southwest logo]()
$256
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:14 pm
BUF
- CHS
1 stop5h 04m
Delta
Sat 6/136:24 pm
CHS
- BUF
1 stop4h 33m
Delta
Deal found 4/6![Delta logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:52 pm
BUF
- MYR
1 stop13h 58m
Multiple Airlines
Fri 6/59:52 pm
MYR
- BUF
2 stops36h 49m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$259
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2612:09 pm
BUF
- SAV
1 stop5h 41m
Delta
Thu 9/310:20 am
SAV
- BUF
1 stop5h 10m
Delta
Deal found 4/9![Delta logo]()
$261
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 9, 2026.
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:02 am
BUF
- SAV
1 stop6h 47m
United Airlines
Tue 5/197:15 pm
SAV
- BUF
1 stop4h 40m
United Airlines
Deal found 4/8![United Airlines logo]()
$251
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/124:00 pm
BUF
- SAV
1 stop4h 25m
Southwest
Thu 5/142:05 pm
SAV
- BUF
2 stops9h 10m
Southwest
Deal found 4/5![Southwest logo]()
$256
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:30 pm
BUF
- CHS
1 stop7h 23m
Delta
Thu 6/115:06 pm
CHS
- BUF
1 stop6h 53m
Delta
Deal found 4/6![Delta logo]()
$257
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:45 pm
BUF
- CHS
1 stop5h 44m
American Airlines
Sat 4/256:00 am
CHS
- BUF
1 stop5h 58m
American Airlines
Deal found 4/4![American Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:52 am
BUF
- GSP
1 stop8h 46m
Multiple Airlines
Sun 4/192:12 pm
GSP
- BUF
2 stops21h 35m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$431
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:25 am
BUF
- SAV
2 stops9h 50m
Southwest
Fri 5/152:05 pm
SAV
- BUF
2 stops8h 40m
Southwest
Deal found 4/7![Southwest logo]()
$261
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:07 am
BUF
- SAV
1 stop4h 38m
Delta
Sun 6/285:39 am
SAV
- BUF
1 stop5h 30m
Delta
Deal found 4/9![Delta logo]()
$261
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:00 am
BUF
- CAE
1 stop3h 56m
United Airlines
Tue 7/77:45 pm
CAE
- BUF
1 stop4h 14m
United Airlines
Deal found 4/5![United Airlines logo]()
$276
This Southwest deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:10 pm
BUF
- CHS
2 stops7h 55m
Southwest
Thu 5/281:15 pm
CHS
- BUF
1 stop5h 00m
Southwest
Deal found 4/9![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:00 am
BUF
- MYR
1 stop4h 26m
American Airlines
Sat 5/95:00 am
MYR
- BUF
2 stops6h 58m
American Airlines
Deal found 4/4![American Airlines logo]()
$297
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:45 am
BUF
- CHS
1 stop5h 02m
Delta
Tue 6/26:55 pm
CHS
- BUF
1 stop4h 37m
Delta
Deal found 4/7![Delta logo]()
$277
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:55 pm
BUF
- SAV
1 stop5h 04m
United Airlines
Sun 4/265:40 am
SAV
- BUF
1 stop4h 20m
United Airlines
Deal found 4/8![United Airlines logo]()
$283
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:00 pm
BUF
- SAV
1 stop5h 20m
Southwest
Wed 4/2911:30 am
SAV
- BUF
1 stop4h 50m
Southwest
Deal found 4/7![Southwest logo]()
$267
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2310:38 am
BUF
- SAV
1 stop7h 08m
American Airlines
Tue 5/267:30 pm
SAV
- BUF
1 stop4h 26m
American Airlines
Deal found 4/4![American Airlines logo]()
$311
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:34 am
BUF
- CAE
1 stop3h 42m
United Airlines
Sun 5/317:45 pm
CAE
- BUF
1 stop4h 14m
United Airlines
Deal found 4/8![United Airlines logo]()
$291
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:10 pm
BUF
- CHS
2 stops7h 55m
Southwest
Tue 5/126:40 am
CHS
- BUF
2 stops7h 55m
Southwest
Deal found 4/5![Southwest logo]()
$267
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:40 pm
BUF
- MYR
1 stop4h 34m
Delta
Thu 5/711:00 am
MYR
- BUF
1 stop6h 01m
Delta
Deal found 4/6![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:00 pm
BUF
- MYR
1 stop6h 45m
Southwest
Fri 6/58:10 pm
MYR
- BUF
1 stop4h 00m
Southwest
Deal found 4/4![Southwest logo]()
$277
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
BUF
- HHH
1 stop5h 28m
Delta
Wed 5/612:08 pm
HHH
- BUF
1 stop6h 27m
Delta
Deal found 4/5![Delta logo]()
$311
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:00 am
BUF
- GSP
2 stops7h 19m
American Airlines
Sat 5/165:20 am
GSP
- BUF
2 stops6h 38m
American Airlines
Deal found 4/8![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:57 pm
BUF
- SAV
1 stop7h 16m
United Airlines
Wed 5/67:15 pm
SAV
- BUF
1 stop4h 40m
United Airlines
Deal found 4/4![United Airlines logo]()
$331
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:04 am
BUF
- HHH
1 stop5h 33m
Delta
Thu 5/1412:18 pm
HHH
- BUF
1 stop6h 26m
Delta
Deal found 4/5![Delta logo]()
$311
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:34 am
BUF
- CHS
2 stops11h 17m
United Airlines
Wed 6/103:34 pm
CHS
- BUF
1 stop6h 57m
United Airlines
Deal found 4/5![United Airlines logo]()
$342
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:00 am
BUF
- CLT
1 stop6h 45m
Southwest
Tue 5/128:00 am
CLT
- BUF
1 stop4h 15m
Southwest
Deal found 4/8![Southwest logo]()
$321
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:13 am
BUF
- CAE
1 stop5h 18m
Delta
Sat 4/257:03 am
CAE
- BUF
1 stop5h 48m
Delta
Deal found 4/6![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:00 am
BUF
- CHS
1 stop5h 25m
United Airlines
Wed 4/292:58 pm
CHS
- BUF
2 stops8h 35m
United Airlines
Deal found 4/4![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:49 am
BUF
- CAE
2 stops7h 16m
American Airlines
Sat 4/255:00 am
CAE
- BUF
2 stops6h 58m
American Airlines
Deal found 4/6![American Airlines logo]()
$424
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:05 am
BUF
- CLT
1 stop4h 30m
Southwest
Tue 4/285:35 pm
CLT
- BUF
1 stop4h 40m
Southwest
Deal found 4/4![Southwest logo]()
$334
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:00 am
BUF
- SAV
1 stop8h 13m
United Airlines
Wed 5/137:15 pm
SAV
- BUF
1 stop4h 40m
United Airlines
Deal found 4/5![United Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:47 pm
BUF
- CLT
1 stop7h 22m
Delta
Mon 5/185:00 pm
CLT
- BUF
1 stop6h 32m
Delta
Deal found 4/4![Delta logo]()
$349
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated April 9, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated April 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:32 pm
BUF
- CHS
2 stops20h 06m
Multiple Airlines
Fri 4/243:21 pm
CHS
- BUF
1 stop19h 28m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:19 am
BUF
- GSP
1 stop8h 19m
Multiple Airlines
Fri 5/18:18 pm
GSP
- BUF
2 stops15h 55m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$228
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:35 pm
BUF
- SAV
1 stop6h 22m
Delta
Fri 5/85:05 pm
SAV
- BUF
1 stop6h 54m
Delta
Deal found 4/4![Delta logo]()
$251
This Southwest deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 pm
BUF
- SAV
1 stop4h 05m
Southwest
Fri 5/82:05 pm
SAV
- BUF
2 stops8h 40m
Southwest
Deal found 4/4![Southwest logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/34:07 pm
BUF
- MYR
1 stop17h 53m
Multiple Airlines
Sun 5/109:50 pm
MYR
- BUF
2 stops36h 51m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$248
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:10 pm
BUF
- CHS
1 stop5h 55m
Southwest
Tue 5/126:40 am
CHS
- BUF
2 stops7h 55m
Southwest
Deal found 4/5![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/102:55 pm
BUF
- SAV
2 stops8h 15m
Southwest
Fri 5/152:05 pm
SAV
- BUF
2 stops8h 40m
Southwest
Deal found 4/7![Southwest logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- CHS
1 stop13h 46m
Multiple Airlines
Thu 5/282:53 pm
CHS
- BUF
1 stop28h 06m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- MYR
1 stop13h 13m
Multiple Airlines
Sun 5/313:53 pm
MYR
- BUF
2 stops42h 48m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:49 pm
BUF
- CHS
2 stops29h 11m
Multiple Airlines
Tue 6/210:38 am
CHS
- BUF
1 stop8h 21m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$195
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:40 pm
BUF
- CHS
1 stop6h 40m
Southwest
Tue 6/26:20 pm
CHS
- BUF
1 stop3h 55m
Southwest
Deal found 4/6![Southwest logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:52 pm
BUF
- MYR
1 stop13h 58m
Multiple Airlines
Fri 6/59:52 pm
MYR
- BUF
2 stops36h 49m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$259
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:19 am
BUF
- CLT
1 stop9h 18m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$76
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:31 pm
BUF
- CLT
1 stop23h 21m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$77
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:31 pm
BUF
- CLT
1 stop23h 42m
Frontier
Deal found 4/8![Frontier logo]()
$78
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:44 am
BUF
- CLT
1 stop8h 53m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$79
This CheapOair deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:41 pm
BUF
- CLT
1 stop21h 02m
Frontier
Deal found 4/8![Frontier logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:52 pm
BUF
- CLT
1 stop20h 51m
Frontier
Deal found 4/5![Frontier logo]()
$83
This Frontier deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:02 am
BUF
- CLT
1 stop5h 28m
Frontier
Deal found 4/4![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:49 pm
BUF
- CLT
1 stop19h 54m
Frontier
Deal found 4/7![Frontier logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/412:32 pm
BUF
- CLT
2 stops25h 39m
Multiple Airlines
Deal found 4/4![Multiple Airlines logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:41 pm
BUF
- CLT
2 stops22h 53m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/912:05 pm
BUF
- CLT
2 stops29h 43m
Frontier
Deal found 4/8![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:41 pm
BUF
- MYR
2 stops32h 19m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$114
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated April 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $195 (Kiwi.com) |
One-way from | $76 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $425 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 5/12
11:02 am-5:49 pm
1 stop6h 47m
Savannah/Hilton Head
Tue 5/19
7:15 pm-11:55 pm
1 stop4h 40m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 5/12
4:00 pm-8:25 pm
1 stop4h 25m
Savannah/Hilton Head
Thu 5/14
2:05 pm-11:15 pm
2 stops9h 10m
$256
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 6/8
2:30 pm-9:53 pm
1 stop7h 23m
Charleston
Thu 6/11
5:06 pm-11:59 pm
1 stop6h 53m
$257
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Mon 5/11
11:25 am-9:15 pm
2 stops9h 50m
Savannah/Hilton Head
Fri 5/15
2:05 pm-10:45 pm
2 stops8h 40m
$261
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Fri 6/26
6:07 am-10:45 am
1 stop4h 38m
Savannah/Hilton Head
Sun 6/28
5:39 am-11:09 am
1 stop5h 30m
$261
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 5/26
1:10 pm-9:05 pm
2 stops7h 55m
Charleston
Thu 5/28
1:15 pm-6:15 pm
1 stop5h 00m
$262
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Fri 4/24
4:00 pm-9:20 pm
1 stop5h 20m
Savannah/Hilton Head
Wed 4/29
11:30 am-4:20 pm
1 stop4h 50m
$267
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 5/5
1:10 pm-9:05 pm
2 stops7h 55m
Charleston
Tue 5/12
6:40 am-2:35 pm
2 stops7h 55m
$267
BuffaloColumbia
BUF - CAE
BUFCAE
Buffalo
Thu 7/2
6:00 am-9:56 am
1 stop3h 56m
Columbia Metropolitan
Tue 7/7
7:45 pm-11:59 pm
1 stop4h 14m
$276
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 6/1
9:45 am-2:47 pm
1 stop5h 02m
Charleston
Tue 6/2
6:55 pm-11:32 pm
1 stop4h 37m
$277
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-SAV
BUF-CHS
BUF-GSP
BUF-CAE
BUF-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-SAV
BUF-CHS
BUF-GSP
BUF-CAE
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, May is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $77). Flying from Buffalo to South Carolina in April is currently the most expensive (average of $118). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from BUF to SC?
Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 9, 2026.
One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 46% on airfare.
What is the cheapest day to fly from Buffalo to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Buffalo to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 9, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on April 9, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$108 | Average$331 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$348 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$279 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$408 | FlexibilityNo cancel fee | On-time63% |