$76+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
May 17 — May 241
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- CHS
1 stop13h 46m
Multiple Airlines
Tue 6/22:39 pm
CHS
- BUF
2 stops44h 02m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:49 pm
BUF
- MYR
2 stops29h 47m
Multiple Airlines
Thu 6/43:53 pm
MYR
- BUF
1 stop27h 06m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:52 pm
BUF
- MYR
1 stop13h 58m
Multiple Airlines
Sun 5/316:00 am
MYR
- BUF
2 stops31h 54m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:19 am
BUF
- GSP
1 stop8h 19m
Multiple Airlines
Fri 5/18:18 pm
GSP
- BUF
1 stop14h 31m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- MYR
1 stop13h 13m
Multiple Airlines
Sat 5/304:32 pm
MYR
- BUF
2 stops18h 09m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- MYR
1 stop13h 13m
Multiple Airlines
Tue 6/29:39 pm
MYR
- BUF
2 stops37h 02m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/78:49 pm
BUF
- GSP
1 stop10h 50m
Multiple Airlines
Sun 6/148:19 am
GSP
- BUF
2 stops29h 36m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:49 pm
BUF
- MYR
1 stop12h 16m
Multiple Airlines
Sun 6/76:00 am
MYR
- BUF
2 stops31h 54m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/92:47 pm
BUF
- MYR
1 stop19h 03m
Multiple Airlines
Thu 5/146:00 am
MYR
- BUF
2 stops31h 54m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$247
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:55 pm
BUF
- SAV
1 stop4h 21m
American Airlines
Sat 5/96:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 4/12![American Airlines logo]()
$250
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
BUF
- SAV
1 stop4h 27m
Delta
Fri 7/246:10 pm
SAV
- BUF
1 stop5h 48m
Delta
Deal found 4/12![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/812:14 pm
BUF
- CHS
1 stop5h 04m
Delta
Sat 6/136:24 pm
CHS
- BUF
1 stop4h 33m
Delta
Deal found 4/13![Delta logo]()
$256
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2026.
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:07 am
BUF
- SAV
1 stop4h 45m
Delta
Thu 7/237:07 pm
SAV
- BUF
1 stop4h 52m
Delta
Deal found 4/12![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:45 pm
BUF
- SAV
1 stop4h 41m
United Airlines
Mon 5/115:45 am
SAV
- BUF
1 stop4h 08m
United Airlines
Deal found 4/13![United Airlines logo]()
$251
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:00 pm
BUF
- GSP
1 stop4h 55m
Southwest
Tue 6/212:50 pm
GSP
- BUF
2 stops9h 25m
Southwest
Deal found 4/15![Southwest logo]()
$286
This JetBlue deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/99:54 am
BUF
- CHS
1 stop8h 19m
JetBlue
Wed 6/107:20 pm
CHS
- BUF
1 stop4h 39m
JetBlue
Deal found 4/13![JetBlue logo]()
$293
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Tue 5/58:11 am
CHS
- BUF
1 stop4h 35m
American Airlines
Deal found 4/13![American Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:15 am
BUF
- SAV
1 stop6h 55m
Delta
Thu 5/286:53 pm
SAV
- BUF
1 stop5h 06m
Delta
Deal found 4/12![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
BUF
- SAV
2 stops8h 43m
United Airlines
Mon 6/87:15 pm
SAV
- BUF
1 stop4h 44m
United Airlines
Deal found 4/13![United Airlines logo]()
$256
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/167:19 pm
BUF
- CHS
1 stop5h 07m
Delta
Thu 7/236:43 pm
CHS
- BUF
1 stop5h 15m
Delta
Deal found 4/12![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/264:00 pm
BUF
- MYR
1 stop4h 30m
Southwest
Sat 5/307:15 pm
MYR
- BUF
1 stop4h 10m
Southwest
Deal found 4/12![Southwest logo]()
$304
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/612:31 pm
BUF
- CHS
1 stop4h 43m
Delta
Thu 6/116:39 pm
CHS
- BUF
1 stop5h 23m
Delta
Deal found 4/12![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:00 pm
BUF
- SAV
1 stop4h 52m
United Airlines
Tue 6/307:15 pm
SAV
- BUF
1 stop4h 44m
United Airlines
Deal found 4/12![United Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:19 pm
BUF
- CHS
1 stop5h 07m
Delta
Thu 7/235:00 pm
CHS
- BUF
1 stop6h 59m
Delta
Deal found 4/12![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:05 am
BUF
- MYR
1 stop4h 30m
Southwest
Sun 5/317:55 pm
MYR
- BUF
1 stop3h 50m
Southwest
Deal found 4/16![Southwest logo]()
$327
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:19 am
BUF
- CAE
1 stop3h 42m
American Airlines
Sat 5/236:05 pm
CAE
- BUF
1 stop3h 57m
American Airlines
Deal found 4/15![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:00 am
BUF
- CHS
1 stop4h 18m
Delta
Mon 6/156:39 pm
CHS
- BUF
1 stop5h 23m
Delta
Deal found 4/14![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am
BUF
- CAE
2 stops8h 12m
United Airlines
Sat 10/107:35 pm
CAE
- BUF
1 stop3h 51m
United Airlines
Deal found 4/13![United Airlines logo]()
$313
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:00 pm
BUF
- GSP
2 stops6h 35m
Southwest
Tue 6/91:50 pm
GSP
- BUF
2 stops7h 35m
Southwest
Deal found 4/15![Southwest logo]()
$331
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:36 am
BUF
- HHH
1 stop4h 50m
American Airlines
Tue 6/2310:57 am
HHH
- BUF
1 stop5h 28m
American Airlines
Deal found 4/17![American Airlines logo]()
$370
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:19 pm
BUF
- CHS
1 stop5h 07m
Delta
Sun 7/266:43 pm
CHS
- BUF
1 stop5h 15m
Delta
Deal found 4/14![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/610:34 am
BUF
- CHS
2 stops11h 17m
United Airlines
Thu 6/1111:31 am
CHS
- BUF
1 stop5h 15m
United Airlines
Deal found 4/12![United Airlines logo]()
$342
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:27 pm
BUF
- CHS
1 stop7h 35m
Delta
Wed 7/226:21 pm
CHS
- BUF
1 stop5h 17m
Delta
Deal found 4/12![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:40 pm
BUF
- CLT
1 stop5h 40m
Southwest
Fri 6/57:50 pm
CLT
- BUF
1 stop4h 20m
Southwest
Deal found 4/13![Southwest logo]()
$349
This United Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:00 am
BUF
- SAV
1 stop8h 13m
United Airlines
Wed 5/137:15 pm
SAV
- BUF
1 stop4h 40m
United Airlines
Deal found 4/11![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/209:25 am
BUF
- MYR
1 stop8h 10m
Southwest
Sun 5/242:15 pm
MYR
- BUF
2 stops8h 15m
Southwest
Deal found 4/16![Southwest logo]()
$353
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2310:38 am
BUF
- CAE
2 stops7h 36m
American Airlines
Mon 5/254:09 pm
CAE
- BUF
1 stop6h 27m
American Airlines
Deal found 4/12![American Airlines logo]()
$430
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
BUF
- SAV
1 stop5h 30m
Delta
Fri 5/85:59 pm
SAV
- BUF
1 stop6h 20m
Delta
Deal found 4/13![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:00 pm
BUF
- GSP
1 stop4h 55m
Southwest
Mon 6/812:55 pm
GSP
- BUF
2 stops9h 40m
Southwest
Deal found 4/15![Southwest logo]()
$354
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:52 pm
BUF
- CLT
1 stop4h 07m
United Airlines
Sun 5/246:15 am
CLT
- BUF
2 stops8h 04m
United Airlines
Deal found 4/13![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:40 pm
BUF
- SAV
1 stop4h 19m
Delta
Mon 5/115:30 am
SAV
- BUF
1 stop5h 43m
Delta
Deal found 4/12![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/115:45 am
BUF
- MYR
1 stop4h 20m
Southwest
Fri 5/151:45 pm
MYR
- BUF
2 stops9h 30m
Southwest
Deal found 4/12![Southwest logo]()
$354
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated April 17, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated April 17, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:19 am
BUF
- GSP
1 stop8h 19m
Multiple Airlines
Fri 5/18:18 pm
GSP
- BUF
1 stop14h 31m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$231
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:55 pm
BUF
- SAV
1 stop4h 21m
American Airlines
Sat 5/96:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 4/12![American Airlines logo]()
$250
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:02 pm
BUF
- CHS
1 stop4h 57m
United Airlines
Sat 5/91:19 pm
CHS
- BUF
1 stop7h 42m
United Airlines
Deal found 4/12![United Airlines logo]()
$257
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:09 pm
BUF
- SAV
1 stop6h 45m
Delta
Fri 5/85:59 pm
SAV
- BUF
1 stop6h 20m
Delta
Deal found 4/13![Delta logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/92:47 pm
BUF
- MYR
1 stop19h 03m
Multiple Airlines
Thu 5/146:00 am
MYR
- BUF
2 stops31h 54m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- CHS
1 stop13h 46m
Multiple Airlines
Tue 6/22:39 pm
CHS
- BUF
2 stops44h 02m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- MYR
1 stop13h 13m
Multiple Airlines
Sat 5/304:32 pm
MYR
- BUF
2 stops18h 09m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- MYR
1 stop13h 13m
Multiple Airlines
Tue 6/29:39 pm
MYR
- BUF
2 stops37h 02m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:52 pm
BUF
- MYR
1 stop13h 58m
Multiple Airlines
Sun 5/316:00 am
MYR
- BUF
2 stops31h 54m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:52 pm
BUF
- MYR
1 stop13h 58m
Multiple Airlines
Sat 5/303:17 pm
MYR
- BUF
2 stops19h 24m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:49 pm
BUF
- MYR
2 stops29h 47m
Multiple Airlines
Thu 6/43:53 pm
MYR
- BUF
1 stop27h 06m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:49 pm
BUF
- MYR
1 stop12h 16m
Multiple Airlines
Sun 6/76:00 am
MYR
- BUF
2 stops31h 54m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$246
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 17, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:31 pm
BUF
- CLT
1 stop23h 21m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$76
This CheapOair deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:41 pm
BUF
- CLT
1 stop21h 02m
Frontier
Deal found 4/15![Frontier logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/99:02 pm
BUF
- CLT
1 stop19h 38m
Frontier
Deal found 4/13![Frontier logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:49 pm
BUF
- CLT
2 stops20h 45m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:41 pm
BUF
- CLT
2 stops18h 30m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:52 pm
BUF
- CHS
1 stop12h 46m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:52 pm
BUF
- CLT
1 stop16h 13m
Frontier
Deal found 4/14![Frontier logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:52 pm
BUF
- MYR
1 stop13h 58m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:31 pm
BUF
- CHS
1 stop14h 27m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3111:36 am
BUF
- CHS
2 stops30h 28m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:36 am
BUF
- MYR
2 stops33h 00m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:49 pm
BUF
- MYR
2 stops29h 47m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$119
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated April 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $210 (Kiwi.com) |
One-way from | $76 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $427 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Wed 7/15
6:07 am-10:52 am
1 stop4h 45m
Savannah/Hilton Head
Thu 7/23
7:07 pm-11:59 pm
1 stop4h 52m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Fri 5/8
2:45 pm-7:26 pm
1 stop4h 41m
Savannah/Hilton Head
Mon 5/11
5:45 am-9:53 am
1 stop4h 08m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Mon 5/25
6:15 am-1:10 pm
1 stop6h 55m
Savannah/Hilton Head
Thu 5/28
6:53 pm-11:59 pm
1 stop5h 06m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Wed 6/3
6:00 am-2:43 pm
2 stops8h 43m
Savannah/Hilton Head
Mon 6/8
7:15 pm-11:59 pm
1 stop4h 44m
$256
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Thu 7/16
7:19 pm-12:26 am
1 stop5h 07m
Charleston
Thu 7/23
6:43 pm-11:58 pm
1 stop5h 15m
$257
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 6/6
12:31 pm-5:14 pm
1 stop4h 43m
Charleston
Thu 6/11
6:39 pm-12:02 am
1 stop5h 23m
$257
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Wed 7/15
7:19 pm-12:26 am
1 stop5h 07m
Charleston
Thu 7/23
5:00 pm-11:59 pm
1 stop6h 59m
$257
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Thu 6/11
6:00 am-10:18 am
1 stop4h 18m
Charleston
Mon 6/15
6:39 pm-12:02 am
1 stop5h 23m
$257
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 7/24
7:19 pm-12:26 am
1 stop5h 07m
Charleston
Sun 7/26
6:43 pm-11:58 pm
1 stop5h 15m
$257
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 7/20
2:27 pm-10:02 pm
1 stop7h 35m
Charleston
Wed 7/22
6:21 pm-11:38 pm
1 stop5h 17m
$257
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-MYR
BUF-CLT
BUF-CHS
BUF-HHH
BUF-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-MYR
BUF-CLT
BUF-CHS
BUF-HHH
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, June is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $80). Flying from Buffalo to South Carolina in January is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 17, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on April 17, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$108 | Average$334 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$355 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$279 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$410 | FlexibilityNo cancel fee | On-time63% |