$67+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Apr 3 — Apr 101
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to South Carolina
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 4, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 4, 2026.
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:00 pm
BUF
- SAV
1 stop4h 50m
Southwest
Tue 4/211:05 pm
SAV
- BUF
1 stop5h 10m
Southwest
Deal found 3/2![Southwest logo]()
$197
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:29 am
BUF
- CHS
1 stop4h 56m
American Airlines
Sat 3/288:17 pm
CHS
- BUF
1 stop3h 33m
American Airlines
Deal found 3/1![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:15 pm
BUF
- SAV
2 stops8h 50m
Southwest
Tue 3/3112:45 pm
SAV
- BUF
1 stop6h 35m
Southwest
Deal found 3/3![Southwest logo]()
$202
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:55 am
BUF
- CHS
1 stop6h 05m
Southwest
Fri 4/242:15 pm
CHS
- BUF
2 stops7h 15m
Southwest
Deal found 3/2![Southwest logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- MYR
1 stop23h 46m
Multiple Airlines
Wed 4/2210:20 am
MYR
- BUF
2 stops25h 20m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$205
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:40 pm
BUF
- SAV
2 stops8h 35m
Southwest
Tue 4/216:40 am
SAV
- BUF
2 stops7h 55m
Southwest
Deal found 3/2![Southwest logo]()
$207
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:35 am
BUF
- CHS
2 stops10h 40m
Southwest
Wed 5/66:40 am
CHS
- BUF
2 stops7h 55m
Southwest
Deal found 3/3![Southwest logo]()
$207
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:45 am
BUF
- SAV
2 stops10h 15m
Southwest
Sat 5/97:15 am
SAV
- BUF
1 stop10h 45m
Southwest
Deal found 3/2![Southwest logo]()
$208
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:20 am
BUF
- CHS
2 stops6h 40m
Southwest
Sat 4/258:00 am
CHS
- BUF
1 stop10h 00m
Southwest
Deal found 3/1![Southwest logo]()
$208
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Sat 4/187:13 pm
CHS
- BUF
1 stop4h 36m
American Airlines
Deal found 3/2![American Airlines logo]()
$209
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/185:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 3/2![Delta logo]()
$211
This CheapOair deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:55 am
BUF
- CLT
1 stop8h 55m
Frontier
Sun 5/319:45 pm
CLT
- BUF
1 stop14h 31m
Frontier
Deal found 3/3![Frontier logo]()
$213
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 4, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 4, 2026.
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:33 pm
BUF
- CHS
1 stop5h 35m
Delta
Sat 5/26:25 am
CHS
- BUF
1 stop4h 36m
Delta
Deal found 3/1![Delta logo]()
$197
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/59:45 am
BUF
- SAV
2 stops10h 15m
Southwest
Sat 5/97:15 am
SAV
- BUF
1 stop10h 45m
Southwest
Deal found 3/2![Southwest logo]()
$208
This United Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:55 pm
BUF
- SAV
1 stop5h 04m
United Airlines
Sat 4/258:00 am
SAV
- BUF
2 stops10h 49m
United Airlines
Deal found 2/27![United Airlines logo]()
$227
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:28 pm
BUF
- SAV
1 stop4h 30m
American Airlines
Tue 4/286:11 am
SAV
- BUF
1 stop6h 35m
American Airlines
Deal found 3/4![American Airlines logo]()
$263
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/255:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 2/27![Delta logo]()
$211
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:15 am
BUF
- CHS
1 stop5h 55m
Delta
Mon 6/14:55 pm
CHS
- BUF
1 stop7h 04m
Delta
Deal found 3/1![Delta logo]()
$218
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/235:55 pm
BUF
- SAV
1 stop3h 55m
Southwest
Fri 3/277:45 pm
SAV
- BUF
1 stop4h 25m
Southwest
Deal found 3/2![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:35 am
BUF
- CHS
2 stops10h 50m
United Airlines
Wed 4/297:44 pm
CHS
- BUF
1 stop4h 08m
United Airlines
Deal found 3/2![United Airlines logo]()
$272
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:42 pm
BUF
- SAV
2 stops6h 16m
American Airlines
Sat 4/186:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/4![American Airlines logo]()
$274
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:38 pm
BUF
- CHS
1 stop4h 38m
Delta
Tue 3/246:00 am
CHS
- BUF
1 stop4h 57m
Delta
Deal found 2/27![Delta logo]()
$238
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2712:40 pm
BUF
- SAV
2 stops8h 35m
Southwest
Sat 5/93:15 pm
SAV
- BUF
2 stops8h 10m
Southwest
Deal found 3/1![Southwest logo]()
$268
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:04 am
BUF
- GSP
1 stop3h 54m
United Airlines
Tue 5/196:27 pm
GSP
- BUF
1 stop5h 06m
United Airlines
Deal found 3/2![United Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:00 am
BUF
- HHH
1 stop6h 37m
American Airlines
Fri 4/175:04 pm
HHH
- BUF
1 stop6h 43m
American Airlines
Deal found 3/3![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:55 pm
BUF
- SAV
1 stop4h 00m
Southwest
Thu 4/232:05 pm
SAV
- BUF
2 stops9h 10m
Southwest
Deal found 3/1![Southwest logo]()
$273
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:00 am
BUF
- MYR
1 stop7h 17m
United Airlines
Sat 5/23:14 pm
MYR
- BUF
1 stop5h 47m
United Airlines
Deal found 3/2![United Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:40 pm
BUF
- SAV
1 stop4h 17m
American Airlines
Wed 4/15:00 am
SAV
- BUF
2 stops7h 14m
American Airlines
Deal found 2/28![American Airlines logo]()
$298
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:00 am
BUF
- HHH
1 stop5h 28m
Delta
Thu 4/2312:08 pm
HHH
- BUF
1 stop6h 27m
Delta
Deal found 3/3![Delta logo]()
$277
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/281:10 pm
BUF
- CHS
2 stops7h 55m
Southwest
Sat 5/211:15 am
CHS
- BUF
2 stops9h 40m
Southwest
Deal found 3/1![Southwest logo]()
$281
This United Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:31 am
BUF
- MYR
1 stop6h 42m
United Airlines
Tue 5/1911:30 am
MYR
- BUF
2 stops12h 25m
United Airlines
Deal found 2/27![United Airlines logo]()
$307
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:15 am
BUF
- MYR
1 stop4h 24m
Delta
Tue 5/196:00 am
MYR
- BUF
1 stop5h 13m
Delta
Deal found 2/27![Delta logo]()
$297
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:50 pm
BUF
- CLT
1 stop6h 55m
United Airlines
Mon 5/186:00 am
CLT
- BUF
1 stop3h 53m
United Airlines
Deal found 3/2![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:17 pm
BUF
- MYR
1 stop6h 57m
Delta
Tue 4/287:02 pm
MYR
- BUF
1 stop4h 35m
Delta
Deal found 3/1![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:10 pm
BUF
- CLT
1 stop4h 35m
Southwest
Thu 4/308:20 am
CLT
- BUF
1 stop3h 40m
Southwest
Deal found 3/3![Southwest logo]()
$328
This United Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:45 am
BUF
- CHS
2 stops10h 40m
United Airlines
Sat 4/252:53 pm
CHS
- BUF
2 stops8h 51m
United Airlines
Deal found 2/28![United Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:23 am
BUF
- CLT
1 stop6h 06m
Delta
Tue 4/75:10 pm
CLT
- BUF
1 stop6h 03m
Delta
Deal found 3/2![Delta logo]()
$301
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:45 pm
BUF
- HHH
1 stop4h 24m
American Airlines
Thu 4/232:58 pm
HHH
- BUF
2 stops9h 01m
American Airlines
Deal found 3/1![American Airlines logo]()
$403
This Southwest deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/263:55 pm
BUF
- CLT
1 stop6h 00m
Southwest
Wed 4/18:10 am
CLT
- BUF
1 stop3h 30m
Southwest
Deal found 2/28![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:00 am
BUF
- HHH
1 stop7h 16m
United Airlines
Thu 4/233:05 pm
HHH
- BUF
1 stop5h 38m
United Airlines
Deal found 3/1![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:25 am
BUF
- HHH
1 stop4h 41m
American Airlines
Sat 5/304:24 pm
HHH
- BUF
1 stop5h 38m
American Airlines
Deal found 3/3![American Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:00 am
BUF
- MYR
2 stops7h 45m
Southwest
Mon 4/271:45 pm
MYR
- BUF
1 stop6h 00m
Southwest
Deal found 3/2![Southwest logo]()
$341
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated March 4, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated March 4, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:15 pm
BUF
- SAV
2 stops8h 50m
Southwest
Tue 3/3112:45 pm
SAV
- BUF
1 stop6h 35m
Southwest
Deal found 3/3![Southwest logo]()
$202
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:29 am
BUF
- CHS
1 stop4h 56m
American Airlines
Sat 3/288:17 pm
CHS
- BUF
1 stop3h 33m
American Airlines
Deal found 3/1![American Airlines logo]()
$197
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Wed 4/156:06 am
CHS
- BUF
1 stop5h 08m
American Airlines
Deal found 3/1![American Airlines logo]()
$215
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/185:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 3/2![Delta logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- MYR
1 stop23h 46m
Multiple Airlines
Wed 4/2210:20 am
MYR
- BUF
2 stops25h 20m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$205
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:28 pm
BUF
- SAV
1 stop4h 30m
American Airlines
Fri 4/176:57 pm
SAV
- BUF
1 stop4h 22m
American Airlines
Deal found 3/3![American Airlines logo]()
$217
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Sat 4/187:13 pm
CHS
- BUF
1 stop4h 36m
American Airlines
Deal found 3/2![American Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:00 pm
BUF
- SAV
1 stop4h 50m
Southwest
Tue 4/211:05 pm
SAV
- BUF
1 stop5h 10m
Southwest
Deal found 3/2![Southwest logo]()
$197
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:55 am
BUF
- CHS
1 stop6h 05m
Southwest
Fri 4/242:15 pm
CHS
- BUF
2 stops7h 15m
Southwest
Deal found 3/2![Southwest logo]()
$202
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:40 pm
BUF
- SAV
2 stops8h 35m
Southwest
Tue 4/216:40 am
SAV
- BUF
2 stops7h 55m
Southwest
Deal found 3/2![Southwest logo]()
$207
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:00 am
BUF
- SAV
2 stops9h 00m
Southwest
Sat 4/257:15 am
SAV
- BUF
1 stop10h 45m
Southwest
Deal found 3/2![Southwest logo]()
$208
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/218:20 am
BUF
- CHS
2 stops6h 40m
Southwest
Sat 4/258:00 am
CHS
- BUF
1 stop10h 00m
Southwest
Deal found 3/1![Southwest logo]()
$208
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 4, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 4, 2026.
This Trip.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CLT
1 stop13h 02m
Multiple Airlines
Deal found 3/1![Multiple Airlines logo]()
$67
This Orbitz deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/111:55 am
BUF
- CLT
1 stop20h 03m
Frontier
Deal found 3/1![Frontier logo]()
$86
This CheapOair deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
BUF
- CLT
1 stop27h 37m
Frontier
Deal found 2/28![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3111:55 am
BUF
- CLT
1 stop20h 14m
Multiple Airlines
Deal found 3/1![Multiple Airlines logo]()
$98
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:39 pm
BUF
- SAV
1 stop4h 15m
American Airlines
Deal found 2/28![American Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
BUF
- CHS
1 stop11h 44m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$99
This Trip.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1912:50 pm
BUF
- CLT
2 stops11h 48m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:55 am
BUF
- CLT
1 stop8h 42m
Multiple Airlines
Deal found 2/28![Multiple Airlines logo]()
$104
This Expedia deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/911:57 am
BUF
- CLT
1 stop12h 39m
Frontier
Deal found 3/2![Frontier logo]()
$107
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:29 pm
BUF
- CHS
1 stop4h 30m
American Airlines
Deal found 3/4![American Airlines logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/301:00 pm
BUF
- CLT
2 stops25h 17m
Frontier
Deal found 3/3![Frontier logo]()
$110
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:40 pm
BUF
- SAV
1 stop4h 17m
American Airlines
Deal found 2/28![American Airlines logo]()
$112
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated March 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $197 (Southwest) |
One-way from | $67 (Trip.com) |
Popular in | April |
Cheapest in | October |
Average price | $382 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 4, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 4/28
3:33 pm-9:08 pm
1 stop5h 35m
Charleston
Sat 5/2
6:25 am-11:01 am
1 stop4h 36m
$197
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 5/5
9:45 am-8:00 pm
2 stops10h 15m
Savannah/Hilton Head
Sat 5/9
7:15 am-6:00 pm
1 stop10h 45m
$208
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 4/11
6:08 pm-11:56 pm
1 stop5h 48m
Savannah/Hilton Head
Sat 4/25
5:35 am-11:01 am
1 stop5h 26m
$211
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 5/29
6:15 am-12:10 pm
1 stop5h 55m
Charleston
Mon 6/1
4:55 pm-11:59 pm
1 stop7h 04m
$218
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 4/11
6:55 pm-11:59 pm
1 stop5h 04m
Savannah/Hilton Head
Sat 4/25
8:00 am-6:49 pm
2 stops10h 49m
$227
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 3/20
7:38 pm-12:16 am
1 stop4h 38m
Charleston
Tue 3/24
6:00 am-10:57 am
1 stop4h 57m
$238
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Mon 3/23
5:55 pm-9:50 pm
1 stop3h 55m
Savannah/Hilton Head
Fri 3/27
7:45 pm-12:10 am
1 stop4h 25m
$247
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Thu 4/16
7:28 pm-11:58 pm
1 stop4h 30m
Savannah/Hilton Head
Tue 4/28
6:11 am-12:46 pm
1 stop6h 35m
$263
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Mon 4/27
12:40 pm-9:15 pm
2 stops8h 35m
Savannah/Hilton Head
Sat 5/9
3:15 pm-11:25 pm
2 stops8h 10m
$268
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 4/25
10:35 am-9:25 pm
2 stops10h 50m
Charleston
Wed 4/29
7:44 pm-11:52 pm
1 stop4h 08m
$272
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-SAV
BUF-CHS
BUF-MYR
BUF-CLT
BUF-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-SAV
BUF-CHS
BUF-MYR
BUF-CLT
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $47). Flying from Buffalo to South Carolina in March is currently the most expensive (average of $119). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from BUF to SC?
Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 4, 2026.
One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 46% on airfare.
What is the cheapest day to fly from Buffalo to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 4, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Overall
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on March 4, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$118 | Average$302 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$337 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$342 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$399 | FlexibilityNo cancel fee | On-time63% |