$110+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Jul 26 — Aug 21
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to South Carolina
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 26, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:00 am
BUF
- CHS
1 stop6h 15m
JetBlue
Tue 8/1110:58 am
CHS
- BUF
1 stop8h 12m
JetBlue
Deal found 6/24![JetBlue logo]()
$194
This JetBlue deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:25 am
BUF
- CHS
1 stop7h 35m
JetBlue
Wed 9/210:58 am
CHS
- BUF
1 stop8h 01m
JetBlue
Deal found 6/22![JetBlue logo]()
$202
This Frontier deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/57:57 pm
BUF
- CLT
1 stop11h 54m
Frontier
Wed 8/1212:24 pm
CLT
- BUF
1 stop6h 42m
Frontier
Deal found 6/24![Frontier logo]()
$210
This Cheapflightsfares deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/37:00 am
BUF
- CHS
1 stop5h 15m
JetBlue
Thu 8/610:58 am
CHS
- BUF
1 stop8h 03m
JetBlue
Deal found 6/22![JetBlue logo]()
$218
This CheapOair deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:09 pm
BUF
- CLT
1 stop14h 20m
Frontier
Wed 8/59:43 pm
CLT
- BUF
1 stop18h 49m
Frontier
Deal found 6/25![Frontier logo]()
$220
This Frontier deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:57 pm
BUF
- CLT
1 stop12h 04m
Frontier
Wed 8/199:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 6/23![Frontier logo]()
$234
This CheapOair deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:54 pm
BUF
- CLT
1 stop18h 56m
Frontier
Sat 8/298:56 am
CLT
- BUF
1 stop24h 27m
Frontier
Deal found 6/22![Frontier logo]()
$235
This Mytrip deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:57 pm
BUF
- CLT
1 stop15h 32m
Frontier
Wed 7/2912:24 pm
CLT
- BUF
1 stop28h 08m
Frontier
Deal found 6/22![Frontier logo]()
$239
This CheapOair deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:09 pm
BUF
- CLT
1 stop19h 49m
Frontier
Tue 7/2112:24 pm
CLT
- BUF
1 stop6h 42m
Frontier
Deal found 6/21![Frontier logo]()
$240
This Super.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Thu 8/202:45 pm
CLT
- BUF
1 stop27h 24m
Frontier
Deal found 6/23![Frontier logo]()
$241
This JetBlue deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 am
BUF
- CHS
1 stop6h 10m
JetBlue
Wed 9/911:05 am
CHS
- BUF
1 stop7h 56m
JetBlue
Deal found 6/24![JetBlue logo]()
$242
This Frontier deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/259:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Wed 8/269:52 pm
CLT
- BUF
1 stop11h 31m
Frontier
Deal found 6/23![Frontier logo]()
$246
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 26, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 26, 2026.
This JetBlue deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
BUF
- CHS
1 stop6h 15m
JetBlue
Wed 9/210:58 am
CHS
- BUF
1 stop8h 01m
JetBlue
Deal found 6/23![JetBlue logo]()
$202
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:05 am
BUF
- CHS
1 stop7h 00m
Delta
Sun 9/276:42 pm
CHS
- BUF
1 stop5h 12m
Delta
Deal found 6/21![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:00 am
BUF
- CHS
2 stops9h 25m
Southwest
Wed 9/26:45 am
CHS
- BUF
2 stops7h 35m
Southwest
Deal found 6/25![Southwest logo]()
$294
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
BUF
- HHH
1 stop7h 05m
United Airlines
Tue 8/182:48 pm
HHH
- BUF
1 stop6h 19m
United Airlines
Deal found 6/24![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 pm
BUF
- CAE
1 stop4h 41m
American Airlines
Tue 7/144:10 pm
CAE
- BUF
1 stop6h 41m
American Airlines
Deal found 6/23![American Airlines logo]()
$347
This JetBlue deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 am
BUF
- CHS
1 stop6h 10m
JetBlue
Wed 9/911:05 am
CHS
- BUF
1 stop7h 56m
JetBlue
Deal found 6/24![JetBlue logo]()
$242
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:05 am
BUF
- CHS
1 stop5h 33m
Delta
Thu 9/245:35 pm
CHS
- BUF
1 stop6h 37m
Delta
Deal found 6/21![Delta logo]()
$267
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am
BUF
- CHS
1 stop4h 40m
Delta
Sun 9/137:10 am
CHS
- BUF
1 stop4h 12m
Delta
Deal found 6/22![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:35 am
BUF
- MYR
2 stops8h 50m
Southwest
Wed 10/288:20 am
MYR
- BUF
1 stop4h 20m
Southwest
Deal found 6/25![Southwest logo]()
$308
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:55 am
BUF
- HHH
1 stop7h 08m
United Airlines
Wed 9/162:48 pm
HHH
- BUF
1 stop6h 19m
United Airlines
Deal found 6/23![United Airlines logo]()
$309
This JetBlue deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/123:10 pm
BUF
- SAV
1 stop8h 47m
JetBlue
Thu 10/152:20 pm
SAV
- BUF
1 stop4h 41m
JetBlue
Deal found 6/22![JetBlue logo]()
$302
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:55 am
BUF
- HHH
1 stop7h 08m
United Airlines
Mon 8/242:48 pm
HHH
- BUF
1 stop6h 19m
United Airlines
Deal found 6/25![United Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:25 am
BUF
- CHS
2 stops9h 45m
Southwest
Tue 7/286:50 pm
CHS
- BUF
1 stop3h 55m
Southwest
Deal found 6/25![Southwest logo]()
$312
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:05 am
BUF
- CAE
1 stop5h 04m
Delta
Tue 8/185:40 am
CAE
- BUF
1 stop5h 28m
Delta
Deal found 6/21![Delta logo]()
$286
This JetBlue deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:10 pm
BUF
- SAV
1 stop8h 47m
JetBlue
Thu 10/152:20 pm
SAV
- BUF
1 stop4h 41m
JetBlue
Deal found 6/24![JetBlue logo]()
$302
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:20 am
BUF
- CHS
2 stops6h 45m
Southwest
Wed 9/27:35 am
CHS
- BUF
2 stops6h 45m
Southwest
Deal found 6/25![Southwest logo]()
$324
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:05 am
BUF
- GSP
1 stop4h 57m
Delta
Tue 8/256:58 pm
GSP
- BUF
1 stop5h 00m
Delta
Deal found 6/23![Delta logo]()
$303
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/26:15 am
BUF
- CHS
1 stop3h 56m
United Airlines
Wed 8/52:47 pm
CHS
- BUF
2 stops8h 19m
United Airlines
Deal found 6/24![United Airlines logo]()
$336
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/236:00 am
BUF
- CLT
1 stop4h 30m
American Airlines
Sun 8/301:05 pm
CLT
- BUF
Nonstop1h 45m
American Airlines
Deal found 6/25![American Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1712:30 pm
BUF
- MYR
1 stop6h 50m
Southwest
Tue 9/228:15 am
MYR
- BUF
2 stops7h 00m
Southwest
Deal found 6/25![Southwest logo]()
$325
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:05 am
BUF
- CAE
1 stop5h 04m
Delta
Mon 8/177:47 pm
CAE
- BUF
1 stop4h 12m
Delta
Deal found 6/21![Delta logo]()
$311
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:00 am
BUF
- CAE
2 stops7h 40m
United Airlines
Sat 9/192:15 pm
CAE
- BUF
1 stop6h 52m
United Airlines
Deal found 6/24![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/810:50 am
BUF
- CHS
1 stop8h 30m
Southwest
Tue 8/116:45 am
CHS
- BUF
2 stops7h 35m
Southwest
Deal found 6/22![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/610:00 am
BUF
- CHS
1 stop6h 27m
Delta
Thu 8/136:43 pm
CHS
- BUF
1 stop5h 15m
Delta
Deal found 6/22![Delta logo]()
$313
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/153:30 pm
BUF
- CHS
1 stop3h 50m
Southwest
Tue 8/186:45 am
CHS
- BUF
2 stops7h 35m
Southwest
Deal found 6/23![Southwest logo]()
$338
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1711:10 am
BUF
- FLO
2 stops12h 27m
American Airlines
Tue 7/215:17 am
FLO
- BUF
1 stop3h 46m
American Airlines
Deal found 6/22![American Airlines logo]()
$501
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:55 am
BUF
- HHH
1 stop7h 08m
United Airlines
Wed 9/22:48 pm
HHH
- BUF
1 stop6h 19m
United Airlines
Deal found 6/23![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:01 am
BUF
- HHH
1 stop5h 33m
Delta
Sat 9/124:10 pm
HHH
- BUF
1 stop5h 10m
Delta
Deal found 6/21![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/612:30 pm
BUF
- MYR
1 stop6h 50m
Southwest
Sun 8/96:45 pm
MYR
- BUF
1 stop4h 05m
Southwest
Deal found 6/23![Southwest logo]()
$345
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 am
BUF
- HHH
2 stops9h 27m
Delta
Tue 9/154:10 pm
HHH
- BUF
1 stop6h 47m
Delta
Deal found 6/21![Delta logo]()
$328
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated June 26, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated June 26, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/79:09 pm
BUF
- CLT
1 stop14h 20m
Frontier
Tue 7/148:02 pm
CLT
- BUF
1 stop23h 04m
Frontier
Deal found 6/23![Frontier logo]()
$258
This Super.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:57 pm
BUF
- CLT
1 stop21h 01m
Frontier
Tue 7/2112:24 pm
CLT
- BUF
1 stop6h 42m
Frontier
Deal found 6/22![Frontier logo]()
$254
This Super.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/129:29 pm
BUF
- CLT
1 stop19h 29m
Frontier
Tue 7/1412:24 pm
CLT
- BUF
1 stop6h 42m
Frontier
Deal found 6/21![Frontier logo]()
$256
This CheapOair deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:09 pm
BUF
- CLT
1 stop19h 49m
Frontier
Tue 7/2112:24 pm
CLT
- BUF
1 stop6h 42m
Frontier
Deal found 6/21![Frontier logo]()
$240
This CheapOair deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1810:02 pm
BUF
- CLT
1 stop13h 27m
Frontier
Sat 7/2512:24 pm
CLT
- BUF
1 stop8h 43m
Frontier
Deal found 6/25![Frontier logo]()
$250
This Super.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1810:02 pm
BUF
- CLT
1 stop13h 27m
Frontier
Mon 7/2712:24 pm
CLT
- BUF
1 stop6h 42m
Frontier
Deal found 6/21![Frontier logo]()
$260
This Cheapflightsfares deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:00 am
BUF
- CHS
1 stop6h 15m
JetBlue
Tue 7/2810:58 am
CHS
- BUF
1 stop7h 28m
JetBlue
Deal found 6/25![JetBlue logo]()
$194
This Mytrip deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:57 pm
BUF
- CLT
1 stop15h 32m
Frontier
Wed 7/2912:24 pm
CLT
- BUF
1 stop28h 08m
Frontier
Deal found 6/22![Frontier logo]()
$239
This JetBlue deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/229:15 am
BUF
- SAV
1 stop8h 40m
JetBlue
Wed 7/2910:56 am
SAV
- BUF
1 stop7h 30m
JetBlue
Deal found 6/24![JetBlue logo]()
$257
This CheapOair deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/239:29 pm
BUF
- CLT
1 stop24h 35m
Frontier
Tue 7/2812:24 pm
CLT
- BUF
1 stop6h 42m
Frontier
Deal found 6/21![Frontier logo]()
$259
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:11 pm
BUF
- CAE
1 stop4h 31m
American Airlines
Tue 8/44:10 pm
CAE
- BUF
1 stop6h 41m
American Airlines
Deal found 6/22![American Airlines logo]()
$261
This CheapOair deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/317:57 pm
BUF
- CLT
1 stop15h 32m
Frontier
Sat 8/812:24 pm
CLT
- BUF
1 stop8h 43m
Frontier
Deal found 6/25![Frontier logo]()
$265
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 26, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 26, 2026.
This Super.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/57:57 pm
BUF
- CLT
1 stop16h 25m
Frontier
Deal found 6/23![Frontier logo]()
$110
This Frontier deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:29 pm
BUF
- CLT
1 stop10h 32m
Frontier
Deal found 6/23![Frontier logo]()
$111
This Cheapflightsfares deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:00 am
BUF
- CHS
1 stop6h 15m
JetBlue
Deal found 6/24![JetBlue logo]()
$113
This CheapOair deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:29 pm
BUF
- CLT
1 stop22h 09m
Frontier
Deal found 6/25![Frontier logo]()
$116
This Super.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:57 pm
BUF
- CLT
1 stop21h 01m
Frontier
Deal found 6/21![Frontier logo]()
$120
This Trip.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:09 pm
BUF
- CLT
1 stop19h 49m
Frontier
Deal found 6/21![Frontier logo]()
$124
This Super.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2510:02 pm
BUF
- CLT
1 stop24h 02m
Frontier
Deal found 6/25![Frontier logo]()
$125
This CheapOair deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:57 pm
BUF
- CLT
1 stop26h 07m
Frontier
Deal found 6/24![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/611:29 am
BUF
- MYR
2 stops44h 32m
Multiple Airlines
Deal found 6/21![Multiple Airlines logo]()
$129
This Trip.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1810:02 pm
BUF
- CLT
1 stop13h 27m
Frontier
Deal found 6/21![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2111:29 am
BUF
- CLT
2 stops30h 34m
Frontier
Deal found 6/21![Frontier logo]()
$134
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:36 pm
BUF
- CHS
1 stop4h 23m
American Airlines
Deal found 6/24![American Airlines logo]()
$134
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated June 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $194 (Cheapflightsfares) |
One-way from | $110 (Super.com) |
Popular in | March |
Cheapest in | September |
Average price | $422 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 26, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 9/1
6:00 am-12:15 pm
1 stop6h 15m
Charleston
Wed 9/2
10:58 am-6:59 pm
1 stop8h 01m
$202
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 9/8
6:00 am-12:10 pm
1 stop6h 10m
Charleston
Wed 9/9
11:05 am-7:01 pm
1 stop7h 56m
$242
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 9/22
6:05 am-1:05 pm
1 stop7h 00m
Charleston
Sun 9/27
6:42 pm-11:54 pm
1 stop5h 12m
$267
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 9/21
6:05 am-11:38 am
1 stop5h 33m
Charleston
Thu 9/24
5:35 pm-12:12 am
1 stop6h 37m
$267
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 9/11
6:00 am-10:40 am
1 stop4h 40m
Charleston
Sun 9/13
7:10 am-11:22 am
1 stop4h 12m
$267
BuffaloColumbia
BUF - CAE
BUFCAE
Buffalo
Thu 8/13
6:05 am-11:09 am
1 stop5h 04m
Columbia Metropolitan
Tue 8/18
5:40 am-11:08 am
1 stop5h 28m
$286
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 8/31
6:00 am-3:25 pm
2 stops9h 25m
Charleston
Wed 9/2
6:45 am-2:20 pm
2 stops7h 35m
$294
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Mon 10/12
3:10 pm-11:57 pm
1 stop8h 47m
Savannah/Hilton Head
Thu 10/15
2:20 pm-7:01 pm
1 stop4h 41m
$302
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 10/13
3:10 pm-11:57 pm
1 stop8h 47m
Savannah/Hilton Head
Thu 10/15
2:20 pm-7:01 pm
1 stop4h 41m
$302
BuffaloGreenville
BUF - GSP
BUFGSP
Buffalo
Tue 8/25
6:05 am-11:02 am
1 stop4h 57m
Greenville
Tue 8/25
6:58 pm-11:58 pm
1 stop5h 00m
$303
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-CHS
BUF-CLT
BUF-SAV
BUF-CAE
BUF-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-CHS
BUF-CLT
BUF-SAV
BUF-CAE
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, March is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $98). Flying from Buffalo to South Carolina in January is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to South Carolina?
How far ahead should I book a flight from Buffalo to South Carolina?
The price you pay for your flight from Buffalo to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 26, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
7.9
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on June 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$180 | Average$250 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$198 | Average$365 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$199 | Average$353 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$200 | Average$279 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$410 | FlexibilityNo cancel fee | On-time63% |