$62+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
May 2 — May 91
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:49 pm
BUF
- CHS
2 stops29h 11m
Multiple Airlines
Tue 6/210:38 am
CHS
- BUF
1 stop8h 21m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:49 pm
BUF
- CHS
1 stop11h 56m
Multiple Airlines
Wed 5/274:34 pm
CHS
- BUF
1 stop26h 25m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- MYR
1 stop14h 49m
Multiple Airlines
Fri 4/1711:52 am
MYR
- BUF
2 stops24h 21m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$244
This Cheapflightsfares deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/89:54 am
BUF
- CHS
1 stop8h 19m
JetBlue
Sat 6/136:58 pm
CHS
- BUF
1 stop4h 50m
JetBlue
Deal found 3/29![JetBlue logo]()
$244
This Cheapflightsfares deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:00 am
BUF
- CHS
1 stop6h 00m
JetBlue
Sat 5/237:20 pm
CHS
- BUF
1 stop4h 39m
JetBlue
Deal found 4/1![JetBlue logo]()
$246
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:30 pm
BUF
- SAV
1 stop4h 10m
Southwest
Thu 5/77:00 pm
SAV
- BUF
1 stop4h 20m
Southwest
Deal found 3/31![Southwest logo]()
$251
This JetBlue deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:45 am
BUF
- CHS
1 stop7h 21m
JetBlue
Fri 6/57:20 pm
CHS
- BUF
1 stop4h 39m
JetBlue
Deal found 3/30![JetBlue logo]()
$251
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/82:30 pm
BUF
- CHS
1 stop7h 23m
Delta
Sat 6/134:20 pm
CHS
- BUF
1 stop4h 52m
Delta
Deal found 3/30![Delta logo]()
$256
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Wed 4/295:21 am
CHS
- BUF
1 stop6h 37m
American Airlines
Deal found 3/30![American Airlines logo]()
$257
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Sun 5/247:00 am
CHS
- BUF
1 stop7h 21m
American Airlines
Deal found 3/28![American Airlines logo]()
$258
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:41 pm
BUF
- CAE
1 stop5h 06m
Delta
Wed 6/34:35 pm
CAE
- BUF
1 stop6h 57m
Delta
Deal found 4/1![Delta logo]()
$261
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:35 am
BUF
- SAV
2 stops11h 05m
Southwest
Sat 5/910:50 am
SAV
- BUF
2 stops7h 10m
Southwest
Deal found 4/1![Southwest logo]()
$261
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 2, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 2, 2026.
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:05 am
BUF
- SAV
1 stop4h 50m
Southwest
Sat 5/237:00 pm
SAV
- BUF
1 stop4h 25m
Southwest
Deal found 4/1![Southwest logo]()
$251
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:00 am
BUF
- SAV
1 stop4h 52m
United Airlines
Sat 6/137:15 pm
SAV
- BUF
1 stop4h 44m
United Airlines
Deal found 4/2![United Airlines logo]()
$251
This JetBlue deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:45 am
BUF
- CHS
1 stop7h 21m
JetBlue
Fri 6/57:20 pm
CHS
- BUF
1 stop4h 39m
JetBlue
Deal found 3/29![JetBlue logo]()
$251
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:00 am
BUF
- CHS
1 stop4h 18m
Delta
Tue 6/306:49 pm
CHS
- BUF
1 stop4h 43m
Delta
Deal found 3/29![Delta logo]()
$257
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:00 am
BUF
- HHH
1 stop6h 37m
American Airlines
Sat 4/186:50 pm
HHH
- BUF
1 stop4h 57m
American Airlines
Deal found 3/28![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:55 pm
BUF
- CHS
1 stop5h 04m
United Airlines
Wed 4/2910:00 am
CHS
- BUF
1 stop4h 17m
United Airlines
Deal found 3/31![United Airlines logo]()
$257
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:41 pm
BUF
- CAE
1 stop5h 06m
Delta
Wed 6/34:35 pm
CAE
- BUF
1 stop6h 57m
Delta
Deal found 4/1![Delta logo]()
$261
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/35:50 am
BUF
- CHS
1 stop4h 20m
Southwest
Sat 5/97:00 am
CHS
- BUF
2 stops11h 00m
Southwest
Deal found 3/31![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/259:30 am
BUF
- CHS
2 stops9h 05m
Southwest
Wed 4/2912:00 pm
CHS
- BUF
1 stop4h 20m
Southwest
Deal found 3/31![Southwest logo]()
$262
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:27 pm
BUF
- SAV
1 stop4h 27m
Delta
Tue 6/306:14 pm
SAV
- BUF
1 stop6h 24m
Delta
Deal found 3/28![Delta logo]()
$271
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:02 pm
BUF
- SAV
1 stop4h 56m
United Airlines
Sun 5/2411:30 am
SAV
- BUF
1 stop5h 22m
United Airlines
Deal found 3/30![United Airlines logo]()
$284
This JetBlue deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:28 pm
BUF
- SAV
1 stop5h 06m
JetBlue
Wed 5/66:00 am
SAV
- BUF
1 stop7h 32m
JetBlue
Deal found 3/28![JetBlue logo]()
$314
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:03 am
BUF
- SAV
1 stop5h 22m
Delta
Tue 6/306:10 pm
SAV
- BUF
1 stop5h 52m
Delta
Deal found 3/28![Delta logo]()
$271
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:50 pm
BUF
- SAV
1 stop4h 09m
United Airlines
Sun 5/105:45 am
SAV
- BUF
1 stop4h 08m
United Airlines
Deal found 3/28![United Airlines logo]()
$288
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/92:00 pm
BUF
- GSP
2 stops6h 40m
Southwest
Sat 5/1610:45 am
GSP
- BUF
2 stops10h 05m
Southwest
Deal found 3/31![Southwest logo]()
$301
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:32 pm
BUF
- CAE
1 stop4h 13m
American Airlines
Tue 5/126:00 am
CAE
- BUF
1 stop5h 14m
American Airlines
Deal found 3/31![American Airlines logo]()
$382
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/223:33 pm
BUF
- GSP
1 stop6h 10m
Delta
Wed 4/295:50 pm
GSP
- BUF
1 stop5h 47m
Delta
Deal found 3/29![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:00 am
BUF
- CAE
2 stops10h 55m
United Airlines
Wed 5/67:38 pm
CAE
- BUF
1 stop4h 17m
United Airlines
Deal found 3/31![United Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:25 am
BUF
- GSP
1 stop4h 30m
Delta
Tue 5/266:14 pm
GSP
- BUF
1 stop5h 18m
Delta
Deal found 3/29![Delta logo]()
$291
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:00 pm
BUF
- CLT
1 stop4h 10m
Southwest
Tue 5/128:00 am
CLT
- BUF
1 stop6h 35m
Southwest
Deal found 3/29![Southwest logo]()
$321
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:00 am
BUF
- HHH
1 stop7h 21m
United Airlines
Sun 7/193:05 pm
HHH
- BUF
1 stop5h 36m
United Airlines
Deal found 3/29![United Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:15 am
BUF
- HHH
1 stop5h 15m
American Airlines
Sat 8/296:15 pm
HHH
- BUF
1 stop5h 54m
American Airlines
Deal found 3/31![American Airlines logo]()
$419
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:00 pm
BUF
- CLT
1 stop5h 30m
Southwest
Sat 5/167:05 am
CLT
- BUF
2 stops10h 55m
Southwest
Deal found 4/2![Southwest logo]()
$326
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:04 am
BUF
- CAE
1 stop3h 55m
United Airlines
Wed 6/36:25 am
CAE
- BUF
2 stops8h 00m
United Airlines
Deal found 4/1![United Airlines logo]()
$321
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
BUF
- HHH
2 stops9h 20m
Delta
Wed 5/612:08 pm
HHH
- BUF
2 stops6h 43m
Delta
Deal found 3/30![Delta logo]()
$321
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:00 pm
BUF
- CLT
2 stops7h 15m
Southwest
Wed 5/66:40 am
CLT
- BUF
2 stops7h 55m
Southwest
Deal found 3/28![Southwest logo]()
$331
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/139:45 am
BUF
- CLT
1 stop6h 33m
Delta
Sat 5/165:00 pm
CLT
- BUF
1 stop5h 54m
Delta
Deal found 3/29![Delta logo]()
$321
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:00 am
BUF
- FLO
2 stops15h 42m
American Airlines
Tue 4/284:02 pm
FLO
- BUF
1 stop6h 38m
American Airlines
Deal found 3/31![American Airlines logo]()
$477
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:00 am
BUF
- HHH
1 stop7h 01m
United Airlines
Sat 9/193:00 pm
HHH
- BUF
1 stop6h 08m
United Airlines
Deal found 4/2![United Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:00 am
BUF
- MYR
2 stops7h 45m
Southwest
Sat 5/211:50 am
MYR
- BUF
1 stop4h 25m
Southwest
Deal found 4/1![Southwest logo]()
$338
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated April 2, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated April 2, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- MYR
1 stop14h 49m
Multiple Airlines
Fri 4/1711:52 am
MYR
- BUF
2 stops24h 21m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$244
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:28 pm
BUF
- SAV
1 stop4h 30m
American Airlines
Tue 4/216:11 am
SAV
- BUF
1 stop6h 35m
American Airlines
Deal found 3/31![American Airlines logo]()
$267
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Wed 4/295:21 am
CHS
- BUF
1 stop6h 37m
American Airlines
Deal found 3/30![American Airlines logo]()
$257
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:00 am
BUF
- CHS
2 stops11h 13m
United Airlines
Thu 4/306:00 am
CHS
- BUF
1 stop3h 53m
United Airlines
Deal found 3/31![United Airlines logo]()
$262
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:30 pm
BUF
- SAV
1 stop4h 10m
Southwest
Thu 5/77:00 pm
SAV
- BUF
1 stop4h 20m
Southwest
Deal found 3/31![Southwest logo]()
$251
This Southwest deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:35 am
BUF
- SAV
2 stops11h 05m
Southwest
Sat 5/910:50 am
SAV
- BUF
2 stops7h 10m
Southwest
Deal found 4/1![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:35 am
BUF
- CHS
2 stops10h 40m
Southwest
Sat 5/97:00 am
CHS
- BUF
2 stops11h 00m
Southwest
Deal found 3/31![Southwest logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:49 pm
BUF
- CHS
1 stop11h 56m
Multiple Airlines
Wed 5/274:34 pm
CHS
- BUF
1 stop26h 25m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$243
This Cheapflightsfares deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:00 am
BUF
- CHS
1 stop6h 00m
JetBlue
Sat 5/237:20 pm
CHS
- BUF
1 stop4h 39m
JetBlue
Deal found 4/1![JetBlue logo]()
$246
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Sun 5/247:00 am
CHS
- BUF
1 stop7h 21m
American Airlines
Deal found 3/28![American Airlines logo]()
$258
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:41 pm
BUF
- CAE
1 stop5h 06m
Delta
Wed 6/34:35 pm
CAE
- BUF
1 stop6h 57m
Delta
Deal found 4/1![Delta logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:49 pm
BUF
- CHS
2 stops29h 11m
Multiple Airlines
Tue 6/210:38 am
CHS
- BUF
1 stop8h 21m
Multiple Airlines
Deal found 4/2![Multiple Airlines logo]()
$222
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 2, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 2, 2026.
This Trip.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:00 pm
BUF
- CLT
1 stop25h 35m
Frontier
Deal found 3/30![Frontier logo]()
$62
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:31 pm
BUF
- CLT
1 stop23h 42m
Frontier
Deal found 3/31![Frontier logo]()
$77
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2011:19 am
BUF
- CLT
1 stop29h 16m
Frontier
Deal found 3/30![Frontier logo]()
$84
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:02 am
BUF
- CLT
1 stop5h 28m
Frontier
Deal found 3/31![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:02 am
BUF
- CLT
1 stop5h 28m
Frontier
Deal found 3/31![Frontier logo]()
$91
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:44 am
BUF
- CLT
1 stop19h 21m
Frontier
Deal found 3/29![Frontier logo]()
$94
This Super.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:49 pm
BUF
- CLT
1 stop24h 06m
Frontier
Deal found 3/29![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:19 am
BUF
- GSP
1 stop8h 19m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$99
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:49 pm
BUF
- CLT
1 stop15h 16m
Frontier
Deal found 3/30![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/281:56 pm
BUF
- CLT
2 stops26h 39m
Frontier
Deal found 3/30![Frontier logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:52 pm
BUF
- CLT
1 stop20h 51m
Frontier
Deal found 3/31![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/301:08 pm
BUF
- CLT
2 stops43h 01m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$105
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated April 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $222 (Kiwi.com) |
One-way from | $62 (Trip.com) |
Popular in | March |
Cheapest in | September |
Average price | $438 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 5/12
6:05 am-10:55 am
1 stop4h 50m
Savannah/Hilton Head
Sat 5/23
7:00 pm-11:25 pm
1 stop4h 25m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Mon 6/8
6:00 am-10:52 am
1 stop4h 52m
Savannah/Hilton Head
Sat 6/13
7:15 pm-11:59 pm
1 stop4h 44m
$251
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 6/1
7:45 am-3:06 pm
1 stop7h 21m
Charleston
Fri 6/5
7:20 pm-11:59 pm
1 stop4h 39m
$251
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Thu 6/25
6:00 am-10:18 am
1 stop4h 18m
Charleston
Tue 6/30
6:49 pm-11:32 pm
1 stop4h 43m
$257
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 4/25
6:55 pm-11:59 pm
1 stop5h 04m
Charleston
Wed 4/29
10:00 am-2:17 pm
1 stop4h 17m
$257
BuffaloColumbia
BUF - CAE
BUFCAE
Buffalo
Wed 5/20
5:41 pm-10:47 pm
1 stop5h 06m
Columbia Metropolitan
Wed 6/3
4:35 pm-11:32 pm
1 stop6h 57m
$261
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sun 5/3
5:50 am-10:10 am
1 stop4h 20m
Charleston
Sat 5/9
7:00 am-6:00 pm
2 stops11h 00m
$262
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 4/25
9:30 am-6:35 pm
2 stops9h 05m
Charleston
Wed 4/29
12:00 pm-4:20 pm
1 stop4h 20m
$262
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Fri 6/26
7:27 pm-11:54 pm
1 stop4h 27m
Savannah/Hilton Head
Tue 6/30
6:14 pm-12:38 am
1 stop6h 24m
$271
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 6/30
6:03 am-11:25 am
1 stop5h 22m
Savannah/Hilton Head
Tue 6/30
6:10 pm-12:02 am
1 stop5h 52m
$271
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-GSP
BUF-SAV
BUF-CHS
BUF-MYR
BUF-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-GSP
BUF-SAV
BUF-CHS
BUF-MYR
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $48). Flying from Buffalo to South Carolina in August is currently the most expensive (average of $118). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from BUF to SC?
Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2026.
One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 46% on airfare.
What is the cheapest day to fly from Buffalo to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Buffalo to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 2, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on April 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$108 | Average$329 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$342 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$340 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$409 | FlexibilityNo cancel fee | On-time63% |