$90+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Apr 18 — Apr 251
One-way
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 19, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 19, 2026.
This Frontier deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:00 pm
BUF
- CLT
1 stop9h 36m
Frontier
Thu 4/169:31 am
CLT
- BUF
1 stop9h 42m
Frontier
Deal found 3/16![Frontier logo]()
$201
This Expedia deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
BUF
- CLT
1 stop27h 37m
Frontier
Thu 4/166:35 pm
CLT
- BUF
1 stop15h 22m
Frontier
Deal found 3/17![Frontier logo]()
$225
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:19 am
BUF
- CLT
Nonstop2h 06m
American Airlines
Sun 4/511:06 am
CLT
- BUF
1 stop9h 23m
American Airlines
Deal found 3/14![American Airlines logo]()
$227
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:49 am
BUF
- CLT
1 stop7h 55m
American Airlines
Fri 5/110:00 pm
CLT
- BUF
Nonstop1h 47m
American Airlines
Deal found 3/14![American Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CLT
1 stop13h 02m
Multiple Airlines
Mon 4/202:28 pm
CLT
- BUF
2 stops46h 14m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:31 pm
BUF
- CHS
1 stop14h 27m
Multiple Airlines
Sat 5/166:18 pm
CHS
- BUF
2 stops16h 23m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$245
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:12 am
BUF
- CLT
1 stop20h 28m
Frontier
Tue 4/145:30 pm
CLT
- BUF
2 stops19h 22m
Frontier
Deal found 3/16![Frontier logo]()
$246
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/185:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 3/18![Delta logo]()
$251
This JetBlue deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:25 pm
BUF
- CHS
1 stop4h 32m
JetBlue
Tue 5/56:00 am
CHS
- BUF
1 stop7h 33m
JetBlue
Deal found 3/17![JetBlue logo]()
$251
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Fri 4/245:04 pm
CHS
- BUF
1 stop4h 55m
American Airlines
Deal found 3/15![American Airlines logo]()
$255
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:42 pm
BUF
- SAV
2 stops6h 16m
American Airlines
Sat 4/186:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/16![American Airlines logo]()
$256
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1812:29 pm
BUF
- CHS
1 stop6h 35m
American Airlines
Sat 4/254:30 pm
CHS
- BUF
1 stop7h 19m
American Airlines
Deal found 3/14![American Airlines logo]()
$256
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 19, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 19, 2026.
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/185:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 3/18![Delta logo]()
$251
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 pm
BUF
- SAV
1 stop4h 05m
Southwest
Thu 5/72:05 pm
SAV
- BUF
1 stop5h 40m
Southwest
Deal found 3/16![Southwest logo]()
$251
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:45 pm
BUF
- SAV
1 stop4h 14m
United Airlines
Fri 4/105:45 am
SAV
- BUF
1 stop4h 15m
United Airlines
Deal found 3/14![United Airlines logo]()
$257
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:00 am
BUF
- HHH
2 stops8h 40m
American Airlines
Sat 5/24:10 pm
HHH
- BUF
1 stop5h 24m
American Airlines
Deal found 3/14![American Airlines logo]()
$302
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:35 am
BUF
- SAV
2 stops8h 40m
United Airlines
Mon 4/205:45 am
SAV
- BUF
1 stop4h 15m
United Airlines
Deal found 3/16![United Airlines logo]()
$262
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:00 pm
BUF
- CHS
1 stop5h 30m
Southwest
Sat 5/168:00 am
CHS
- BUF
1 stop10h 00m
Southwest
Deal found 3/17![Southwest logo]()
$262
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:00 am
BUF
- CHS
1 stop5h 12m
Delta
Mon 6/85:55 pm
CHS
- BUF
1 stop6h 03m
Delta
Deal found 3/14![Delta logo]()
$273
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/54:55 pm
BUF
- CHS
1 stop4h 57m
Delta
Mon 6/86:30 pm
CHS
- BUF
1 stop4h 33m
Delta
Deal found 3/14![Delta logo]()
$273
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:10 pm
BUF
- GSP
2 stops8h 30m
Southwest
Wed 6/38:20 am
GSP
- BUF
1 stop3h 55m
Southwest
Deal found 3/18![Southwest logo]()
$276
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
BUF
- SAV
2 stops8h 11m
United Airlines
Mon 9/71:00 pm
SAV
- BUF
1 stop8h 08m
United Airlines
Deal found 3/14![United Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:10 pm
BUF
- GSP
2 stops8h 30m
Southwest
Sat 4/258:00 am
GSP
- BUF
2 stops10h 00m
Southwest
Deal found 3/17![Southwest logo]()
$291
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:39 pm
BUF
- CHS
1 stop4h 20m
Delta
Mon 6/16:03 pm
CHS
- BUF
1 stop5h 56m
Delta
Deal found 3/17![Delta logo]()
$297
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:00 am
BUF
- HHH
1 stop7h 16m
United Airlines
Fri 4/243:05 pm
HHH
- BUF
1 stop5h 38m
United Airlines
Deal found 3/18![United Airlines logo]()
$311
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:00 pm
BUF
- CHS
1 stop5h 30m
Southwest
Wed 4/297:15 am
CHS
- BUF
2 stops7h 20m
Southwest
Deal found 3/16![Southwest logo]()
$292
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
BUF
- HHH
1 stop5h 28m
Delta
Tue 5/124:16 pm
HHH
- BUF
1 stop7h 16m
Delta
Deal found 3/18![Delta logo]()
$311
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:50 pm
BUF
- CHS
1 stop4h 09m
United Airlines
Tue 5/59:40 am
CHS
- BUF
1 stop7h 14m
United Airlines
Deal found 3/14![United Airlines logo]()
$327
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1011:00 am
BUF
- CHS
2 stops9h 25m
Southwest
Mon 6/157:35 pm
CHS
- BUF
1 stop4h 35m
Southwest
Deal found 3/17![Southwest logo]()
$302
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
BUF
- HHH
2 stops9h 20m
Delta
Tue 5/124:16 pm
HHH
- BUF
1 stop7h 16m
Delta
Deal found 3/18![Delta logo]()
$316
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:00 am
BUF
- CAE
2 stops10h 55m
United Airlines
Wed 4/223:25 pm
CAE
- BUF
1 stop5h 18m
United Airlines
Deal found 3/18![United Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:00 am
BUF
- MYR
1 stop5h 03m
Delta
Wed 4/2910:26 am
MYR
- BUF
1 stop5h 27m
Delta
Deal found 3/19![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1112:29 pm
BUF
- FLO
2 stops9h 18m
American Airlines
Tue 4/144:02 pm
FLO
- BUF
1 stop6h 38m
American Airlines
Deal found 3/17![American Airlines logo]()
$534
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:00 am
BUF
- MYR
2 stops6h 35m
Southwest
Tue 4/217:35 am
MYR
- BUF
1 stop4h 40m
Southwest
Deal found 3/15![Southwest logo]()
$338
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:04 am
BUF
- CLT
1 stop3h 49m
United Airlines
Sun 5/106:00 am
CLT
- BUF
1 stop3h 53m
United Airlines
Deal found 3/18![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
BUF
- HHH
2 stops8h 20m
Delta
Tue 8/184:00 pm
HHH
- BUF
1 stop7h 00m
Delta
Deal found 3/14![Delta logo]()
$322
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
BUF
- GSP
1 stop5h 14m
United Airlines
Tue 5/56:27 pm
GSP
- BUF
1 stop5h 06m
United Airlines
Deal found 3/16![United Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:39 pm
BUF
- CAE
1 stop4h 10m
Delta
Mon 5/257:17 pm
CAE
- BUF
1 stop4h 42m
Delta
Deal found 3/14![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1512:40 pm
BUF
- CHS
1 stop6h 40m
Southwest
Tue 5/197:40 am
CHS
- BUF
2 stops8h 55m
Southwest
Deal found 3/14![Southwest logo]()
$362
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/137:00 am
BUF
- MYR
1 stop7h 17m
United Airlines
Mon 4/203:15 pm
MYR
- BUF
1 stop5h 28m
United Airlines
Deal found 3/16![United Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/412:40 pm
BUF
- MYR
2 stops9h 00m
Southwest
Sun 6/77:45 pm
MYR
- BUF
1 stop4h 10m
Southwest
Deal found 3/17![Southwest logo]()
$365
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:00 am
BUF
- MYR
1 stop5h 03m
Delta
Sat 4/256:00 am
MYR
- BUF
1 stop5h 01m
Delta
Deal found 3/19![Delta logo]()
$333
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated March 19, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated March 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:19 am
BUF
- CLT
Nonstop2h 06m
American Airlines
Sun 4/511:06 am
CLT
- BUF
1 stop9h 23m
American Airlines
Deal found 3/14![American Airlines logo]()
$227
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:45 pm
BUF
- SAV
1 stop4h 14m
United Airlines
Fri 4/105:45 am
SAV
- BUF
1 stop4h 15m
United Airlines
Deal found 3/16![United Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/811:12 am
BUF
- CLT
1 stop20h 28m
Frontier
Tue 4/145:30 pm
CLT
- BUF
2 stops19h 22m
Frontier
Deal found 3/16![Frontier logo]()
$246
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:08 pm
BUF
- SAV
1 stop5h 48m
Delta
Sat 4/185:35 am
SAV
- BUF
1 stop5h 26m
Delta
Deal found 3/18![Delta logo]()
$251
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:42 pm
BUF
- SAV
2 stops6h 16m
American Airlines
Sat 4/186:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/16![American Airlines logo]()
$256
This Expedia deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
BUF
- CLT
1 stop27h 37m
Frontier
Thu 4/166:35 pm
CLT
- BUF
1 stop15h 22m
Frontier
Deal found 3/17![Frontier logo]()
$225
This Frontier deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:00 pm
BUF
- CLT
1 stop9h 36m
Frontier
Thu 4/169:31 am
CLT
- BUF
1 stop9h 42m
Frontier
Deal found 3/16![Frontier logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CLT
1 stop13h 02m
Multiple Airlines
Mon 4/202:28 pm
CLT
- BUF
2 stops46h 14m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$240
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Fri 4/245:04 pm
CHS
- BUF
1 stop4h 55m
American Airlines
Deal found 3/15![American Airlines logo]()
$255
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1812:29 pm
BUF
- CHS
1 stop6h 35m
American Airlines
Sat 4/254:30 pm
CHS
- BUF
1 stop7h 19m
American Airlines
Deal found 3/14![American Airlines logo]()
$256
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:40 pm
BUF
- CHS
1 stop4h 42m
Delta
Sat 4/255:20 am
CHS
- BUF
1 stop5h 41m
Delta
Deal found 3/19![Delta logo]()
$257
This Expedia deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:28 pm
BUF
- CHS
1 stop6h 54m
JetBlue
Sun 5/36:00 am
CHS
- BUF
1 stop7h 33m
JetBlue
Deal found 3/17![JetBlue logo]()
$251
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 19, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 19, 2026.
This Frontier deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1311:02 am
BUF
- CLT
1 stop5h 53m
Frontier
Deal found 3/15![Frontier logo]()
$90
This Orbitz deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/263:58 pm
BUF
- CLT
1 stop17h 29m
Frontier
Deal found 3/16![Frontier logo]()
$96
This CheapOair deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/128:59 pm
BUF
- CLT
1 stop27h 37m
Frontier
Deal found 3/17![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CLT
1 stop25h 47m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:32 pm
BUF
- CLT
2 stops28h 03m
Frontier
Deal found 3/18![Frontier logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CHS
1 stop12h 22m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1912:07 pm
BUF
- CLT
2 stops23h 38m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:31 pm
BUF
- CLT
1 stop25h 06m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:11 pm
BUF
- CLT
2 stops19h 59m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:56 pm
BUF
- CLT
2 stops26h 39m
Frontier
Deal found 3/15![Frontier logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:49 pm
BUF
- CLT
1 stop27h 10m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$120
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/1411:55 am
BUF
- CLT
1 stop20h 03m
Frontier
Deal found 3/15![Frontier logo]()
$121
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated March 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $201 (Frontier) |
One-way from | $90 (Frontier) |
Popular in | March |
Cheapest in | September |
Average price | $445 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 19, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 4/11
6:08 pm-11:56 pm
1 stop5h 48m
Savannah/Hilton Head
Sat 4/18
5:35 am-11:01 am
1 stop5h 26m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 5/2
5:00 pm-9:05 pm
1 stop4h 05m
Savannah/Hilton Head
Thu 5/7
2:05 pm-7:45 pm
1 stop5h 40m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 4/7
7:45 pm-11:59 pm
1 stop4h 14m
Savannah/Hilton Head
Fri 4/10
5:45 am-10:00 am
1 stop4h 15m
$257
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Tue 4/14
10:35 am-7:15 pm
2 stops8h 40m
Savannah/Hilton Head
Mon 4/20
5:45 am-10:00 am
1 stop4h 15m
$262
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Mon 5/11
4:00 pm-9:30 pm
1 stop5h 30m
Charleston
Sat 5/16
8:00 am-6:00 pm
1 stop10h 00m
$262
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Wed 6/3
7:00 am-12:12 pm
1 stop5h 12m
Charleston
Mon 6/8
5:55 pm-11:58 pm
1 stop6h 03m
$273
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 6/5
4:55 pm-9:52 pm
1 stop4h 57m
Charleston
Mon 6/8
6:30 pm-11:03 pm
1 stop4h 33m
$273
BuffaloGreenville
BUF - GSP
BUFGSP
Buffalo
Tue 5/26
1:10 pm-9:40 pm
2 stops8h 30m
Greenville
Wed 6/3
8:20 am-12:15 pm
1 stop3h 55m
$276
BuffaloGreenville
BUF - GSP
BUFGSP
Buffalo
Wed 4/22
1:10 pm-9:40 pm
2 stops8h 30m
Greenville
Sat 4/25
8:00 am-6:00 pm
2 stops10h 00m
$291
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 4/24
4:00 pm-9:30 pm
1 stop5h 30m
Charleston
Wed 4/29
7:15 am-2:35 pm
2 stops7h 20m
$292
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-CLT
BUF-CHS
BUF-SAV
BUF-MYR
BUF-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-CLT
BUF-CHS
BUF-SAV
BUF-MYR
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $48). Flying from Buffalo to South Carolina in August is currently the most expensive (average of $118). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from BUF to SC?
Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 19, 2026.
One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 46% on airfare.
What is the cheapest day to fly from Buffalo to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 19, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on March 19, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$108 | Average$315 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$343 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$332 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$410 | FlexibilityNo cancel fee | On-time63% |