$67+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
Apr 29 — May 61
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:59 pm
BUF
- SAV
1 stop3h 54m
American Airlines
Tue 4/286:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/24![American Airlines logo]()
$171
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:28 pm
BUF
- SAV
1 stop4h 30m
American Airlines
Tue 4/216:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/24![American Airlines logo]()
$186
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:28 pm
BUF
- SAV
1 stop4h 30m
American Airlines
Tue 4/216:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$201
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:00 am
BUF
- CHS
1 stop4h 16m
United Airlines
Wed 6/103:34 pm
CHS
- BUF
1 stop6h 57m
United Airlines
Deal found 3/25![United Airlines logo]()
$201
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:00 am
BUF
- SAV
2 stops8h 43m
United Airlines
Mon 6/83:14 pm
SAV
- BUF
1 stop5h 49m
United Airlines
Deal found 3/25![United Airlines logo]()
$204
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Wed 4/297:40 pm
CHS
- BUF
1 stop4h 19m
American Airlines
Deal found 3/26![American Airlines logo]()
$204
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Sat 5/97:13 pm
CHS
- BUF
1 stop4h 36m
American Airlines
Deal found 3/25![American Airlines logo]()
$205
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:45 am
BUF
- SAV
2 stops8h 34m
United Airlines
Sat 5/27:15 pm
SAV
- BUF
1 stop4h 40m
United Airlines
Deal found 3/26![United Airlines logo]()
$206
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:44 am
BUF
- CHS
1 stop4h 59m
American Airlines
Sat 4/257:13 pm
CHS
- BUF
1 stop4h 36m
American Airlines
Deal found 3/25![American Airlines logo]()
$209
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2610:44 am
BUF
- SAV
1 stop7h 32m
American Airlines
Tue 4/286:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$211
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:35 am
BUF
- SAV
2 stops8h 40m
United Airlines
Tue 4/287:18 pm
SAV
- BUF
1 stop4h 32m
United Airlines
Deal found 3/24![United Airlines logo]()
$215
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:05 pm
BUF
- SAV
1 stop4h 25m
Southwest
Fri 6/53:55 pm
SAV
- BUF
2 stops8h 15m
Southwest
Deal found 3/26![Southwest logo]()
$217
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:42 pm
BUF
- SAV
2 stops6h 16m
American Airlines
Tue 4/216:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/24![American Airlines logo]()
$191
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:00 am
BUF
- MYR
1 stop5h 03m
Delta
Wed 5/67:02 pm
MYR
- BUF
1 stop4h 35m
Delta
Deal found 3/25![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:00 am
BUF
- SAV
1 stop7h 16m
United Airlines
Mon 6/811:30 am
SAV
- BUF
1 stop5h 16m
United Airlines
Deal found 3/27![United Airlines logo]()
$251
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:10 pm
BUF
- CLT
1 stop5h 45m
Southwest
Fri 5/86:15 am
CLT
- BUF
2 stops9h 10m
Southwest
Deal found 3/25![Southwest logo]()
$300
This JetBlue deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/22:28 pm
BUF
- SAV
1 stop5h 06m
JetBlue
Wed 5/66:00 am
SAV
- BUF
1 stop7h 32m
JetBlue
Deal found 3/27![JetBlue logo]()
$314
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
BUF
- MYR
1 stop5h 03m
Delta
Tue 4/286:00 am
MYR
- BUF
1 stop5h 01m
Delta
Deal found 3/24![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2410:34 am
BUF
- CHS
1 stop3h 53m
United Airlines
Fri 5/293:08 pm
CHS
- BUF
2 stops8h 51m
United Airlines
Deal found 3/27![United Airlines logo]()
$262
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:59 pm
BUF
- MYR
1 stop7h 15m
Delta
Wed 4/297:02 pm
MYR
- BUF
1 stop4h 35m
Delta
Deal found 3/26![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:00 am
BUF
- CHS
1 stop4h 18m
Delta
Tue 6/306:49 pm
CHS
- BUF
1 stop4h 43m
Delta
Deal found 3/29![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:00 am
BUF
- CHS
1 stop4h 16m
United Airlines
Thu 6/1111:31 am
CHS
- BUF
1 stop5h 15m
United Airlines
Deal found 3/26![United Airlines logo]()
$285
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:00 am
BUF
- HHH
1 stop6h 37m
American Airlines
Sat 4/186:50 pm
HHH
- BUF
1 stop4h 57m
American Airlines
Deal found 3/28![American Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:00 pm
BUF
- CLT
1 stop4h 45m
Southwest
Mon 5/187:20 pm
CLT
- BUF
1 stop4h 00m
Southwest
Deal found 3/27![Southwest logo]()
$325
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:03 am
BUF
- CHS
1 stop4h 41m
Delta
Tue 6/306:49 pm
CHS
- BUF
1 stop4h 43m
Delta
Deal found 3/28![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:00 am
BUF
- HHH
1 stop7h 21m
United Airlines
Fri 6/53:05 pm
HHH
- BUF
1 stop5h 58m
United Airlines
Deal found 3/25![United Airlines logo]()
$296
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:15 am
BUF
- CAE
1 stop6h 59m
Delta
Sat 5/166:40 am
CAE
- BUF
1 stop4h 43m
Delta
Deal found 3/27![Delta logo]()
$261
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:00 pm
BUF
- MYR
1 stop3h 45m
Southwest
Sat 5/305:05 pm
MYR
- BUF
2 stops6h 20m
Southwest
Deal found 3/24![Southwest logo]()
$350
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/111:45 pm
BUF
- HHH
1 stop4h 35m
American Airlines
Sat 4/184:10 pm
HHH
- BUF
1 stop5h 24m
American Airlines
Deal found 3/27![American Airlines logo]()
$370
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2510:50 am
BUF
- SAV
1 stop6h 46m
United Airlines
Wed 9/306:15 am
SAV
- BUF
2 stops7h 31m
United Airlines
Deal found 3/27![United Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:45 am
BUF
- MYR
2 stops7h 20m
Southwest
Fri 4/2410:55 am
MYR
- BUF
2 stops8h 50m
Southwest
Deal found 3/26![Southwest logo]()
$355
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
BUF
- HHH
1 stop5h 28m
Delta
Wed 5/612:08 pm
HHH
- BUF
1 stop6h 27m
Delta
Deal found 3/27![Delta logo]()
$269
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:00 am
BUF
- SAV
2 stops11h 49m
United Airlines
Sun 5/105:45 am
SAV
- BUF
1 stop4h 08m
United Airlines
Deal found 3/26![United Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:00 pm
BUF
- CHS
1 stop4h 00m
Southwest
Mon 5/182:15 pm
CHS
- BUF
2 stops7h 15m
Southwest
Deal found 3/26![Southwest logo]()
$357
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:00 am
BUF
- HHH
1 stop7h 21m
United Airlines
Sun 7/193:05 pm
HHH
- BUF
1 stop5h 36m
United Airlines
Deal found 3/29![United Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/223:33 pm
BUF
- GSP
1 stop6h 10m
Delta
Wed 4/295:50 pm
GSP
- BUF
1 stop5h 47m
Delta
Deal found 3/29![Delta logo]()
$291
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:00 am
BUF
- CLT
2 stops9h 55m
Southwest
Wed 4/297:35 am
CLT
- BUF
2 stops8h 45m
Southwest
Deal found 3/24![Southwest logo]()
$363
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:09 am
BUF
- HHH
2 stops8h 07m
United Airlines
Fri 4/243:05 pm
HHH
- BUF
1 stop5h 38m
United Airlines
Deal found 3/25![United Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:30 am
BUF
- FLO
2 stops10h 20m
American Airlines
Tue 5/265:05 am
FLO
- BUF
2 stops9h 16m
American Airlines
Deal found 3/29![American Airlines logo]()
$483
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/262:55 pm
BUF
- MYR
1 stop3h 35m
Southwest
Wed 5/67:35 am
MYR
- BUF
1 stop4h 40m
Southwest
Deal found 3/28![Southwest logo]()
$370
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:39 pm
BUF
- MYR
1 stop4h 19m
Delta
Mon 6/154:16 pm
MYR
- BUF
1 stop18h 53m
Delta
Deal found 3/25![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:10 am
BUF
- SAV
1 stop4h 34m
United Airlines
Wed 5/67:15 pm
SAV
- BUF
1 stop4h 40m
United Airlines
Deal found 3/25![United Airlines logo]()
$319
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated March 30, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated March 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:30 am
BUF
- CHS
1 stop5h 07m
American Airlines
Wed 4/154:46 pm
CHS
- BUF
1 stop7h 01m
American Airlines
Deal found 3/25![American Airlines logo]()
$225
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1111:49 am
BUF
- SAV
1 stop5h 49m
American Airlines
Sat 4/186:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:28 pm
BUF
- SAV
1 stop4h 30m
American Airlines
Tue 4/216:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$201
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:45 pm
BUF
- SAV
1 stop4h 14m
United Airlines
Tue 4/2110:50 am
SAV
- BUF
2 stops7h 59m
United Airlines
Deal found 3/24![United Airlines logo]()
$231
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:28 pm
BUF
- SAV
1 stop4h 30m
American Airlines
Tue 4/216:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/24![American Airlines logo]()
$186
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:44 am
BUF
- CHS
1 stop4h 59m
American Airlines
Sat 4/257:13 pm
CHS
- BUF
1 stop4h 36m
American Airlines
Deal found 3/25![American Airlines logo]()
$209
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:35 pm
BUF
- CHS
1 stop5h 33m
Delta
Sat 4/255:20 am
CHS
- BUF
1 stop5h 41m
Delta
Deal found 3/26![Delta logo]()
$219
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:59 pm
BUF
- SAV
1 stop3h 54m
American Airlines
Tue 4/286:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/24![American Airlines logo]()
$171
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:35 am
BUF
- SAV
2 stops8h 40m
United Airlines
Tue 4/287:18 pm
SAV
- BUF
1 stop4h 32m
United Airlines
Deal found 3/24![United Airlines logo]()
$215
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Wed 4/297:40 pm
CHS
- BUF
1 stop4h 19m
American Airlines
Deal found 3/26![American Airlines logo]()
$204
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:45 am
BUF
- SAV
2 stops8h 34m
United Airlines
Sat 5/27:15 pm
SAV
- BUF
1 stop4h 40m
United Airlines
Deal found 3/26![United Airlines logo]()
$206
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2610:44 am
BUF
- SAV
1 stop7h 32m
American Airlines
Tue 4/286:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 3/25![American Airlines logo]()
$211
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:16 pm
BUF
- CLT
1 stop20h 19m
Frontier
Deal found 3/29![Frontier logo]()
$67
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:44 am
BUF
- CLT
1 stop19h 21m
Frontier
Deal found 3/27![Frontier logo]()
$82
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:30 am
BUF
- SAV
1 stop4h 59m
American Airlines
Deal found 3/26![American Airlines logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:31 pm
BUF
- CHS
1 stop14h 27m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$86
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/295:30 am
BUF
- CHS
1 stop5h 07m
American Airlines
Deal found 3/25![American Airlines logo]()
$87
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:02 am
BUF
- CLT
1 stop5h 28m
Frontier
Deal found 3/27![Frontier logo]()
$90
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2811:00 am
BUF
- SAV
2 stops9h 00m
Southwest
Deal found 3/26![Southwest logo]()
$91
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:45 pm
BUF
- CLT
1 stop7h 51m
Frontier
Deal found 3/28![Frontier logo]()
$91
This Super.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:49 pm
BUF
- CLT
1 stop24h 06m
Frontier
Deal found 3/29![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:19 am
BUF
- GSP
1 stop8h 19m
Multiple Airlines
Deal found 3/29![Multiple Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:52 pm
BUF
- CLT
1 stop20h 51m
Frontier
Deal found 3/26![Frontier logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:19 am
BUF
- CLT
1 stop22h 43m
Multiple Airlines
Deal found 3/25![Multiple Airlines logo]()
$100
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated March 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $171 (American Airlines) |
One-way from | $67 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $445 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 4/18
5:42 pm-11:58 pm
2 stops6h 16m
Savannah/Hilton Head
Tue 4/21
6:57 pm-11:49 pm
1 stop4h 52m
$191
BuffaloMyrtle Beach
BUF - MYR
BUFMYR
Buffalo
Wed 4/29
6:00 am-11:03 am
1 stop5h 03m
Myrtle Beach Intl
Wed 5/6
7:02 pm-11:37 pm
1 stop4h 35m
$251
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Wed 6/3
7:00 am-2:16 pm
1 stop7h 16m
Savannah/Hilton Head
Mon 6/8
11:30 am-4:46 pm
1 stop5h 16m
$251
BuffaloMyrtle Beach
BUF - MYR
BUFMYR
Buffalo
Tue 4/21
6:00 am-11:03 am
1 stop5h 03m
Myrtle Beach Intl
Tue 4/28
6:00 am-11:01 am
1 stop5h 01m
$251
BuffaloMyrtle Beach
BUF - MYR
BUFMYR
Buffalo
Wed 4/22
4:59 pm-12:14 am
1 stop7h 15m
Myrtle Beach Intl
Wed 4/29
7:02 pm-11:37 pm
1 stop4h 35m
$251
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Thu 6/25
6:00 am-10:18 am
1 stop4h 18m
Charleston
Tue 6/30
6:49 pm-11:32 pm
1 stop4h 43m
$257
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Tue 6/30
6:03 am-10:44 am
1 stop4h 41m
Charleston
Tue 6/30
6:49 pm-11:32 pm
1 stop4h 43m
$257
BuffaloColumbia
BUF - CAE
BUFCAE
Buffalo
Sat 5/9
6:15 am-1:14 pm
1 stop6h 59m
Columbia Metropolitan
Sat 5/16
6:40 am-11:23 am
1 stop4h 43m
$261
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sun 5/24
10:34 am-2:27 pm
1 stop3h 53m
Charleston
Fri 5/29
3:08 pm-11:59 pm
2 stops8h 51m
$262
BuffaloHilton Head Island
BUF - HHH
BUFHHH
Buffalo
Mon 5/4
6:00 am-11:28 am
1 stop5h 28m
Hilton Head Island
Wed 5/6
12:08 pm-6:35 pm
1 stop6h 27m
$269
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-SAV
BUF-CHS
BUF-MYR
BUF-GSP
BUF-CLT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-SAV
BUF-CHS
BUF-MYR
BUF-GSP
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, April is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $48). Flying from Buffalo to South Carolina in August is currently the most expensive (average of $118). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from BUF to SC?
Find hourly flight availability from Buffalo to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 30, 2026.
One of the essential ways to save on airfare from Buffalo to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 46% on airfare.
What is the cheapest day to fly from Buffalo to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Buffalo to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Buffalo to South Carolina flight should consider departing on Sunday at noon when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Buffalo to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 30, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Buffalo to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on March 30, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$108 | Average$327 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$344 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$340 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$409 | FlexibilityNo cancel fee | On-time63% |