$74+ Cheap flights from Buffalo (BUF) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — CHS
May 24 — May 311
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Buffalo to South CarolinaExplore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
Explore the most affordable flight options available from Buffalo to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2010:44 am
BUF
- SAV
1 stop7h 32m
American Airlines
Wed 5/277:30 pm
SAV
- BUF
1 stop4h 26m
American Airlines
Deal found 4/22![American Airlines logo]()
$171
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:30 am
BUF
- CHS
1 stop5h 07m
American Airlines
Wed 5/277:47 pm
CHS
- BUF
1 stop4h 09m
American Airlines
Deal found 4/22![American Airlines logo]()
$173
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:59 pm
BUF
- SAV
1 stop3h 54m
American Airlines
Sat 5/166:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 4/20![American Airlines logo]()
$186
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am
BUF
- CHS
1 stop4h 59m
American Airlines
Sat 9/266:38 pm
CHS
- BUF
1 stop5h 18m
American Airlines
Deal found 4/23![American Airlines logo]()
$189
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:04 am
BUF
- SAV
2 stops9h 09m
United Airlines
Wed 5/273:14 pm
SAV
- BUF
1 stop5h 49m
United Airlines
Deal found 4/22![United Airlines logo]()
$194
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/610:34 am
BUF
- SAV
1 stop4h 09m
United Airlines
Tue 6/911:30 am
SAV
- BUF
1 stop5h 16m
United Airlines
Deal found 4/20![United Airlines logo]()
$195
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:04 am
BUF
- CHS
1 stop4h 35m
Delta
Tue 6/26:15 am
CHS
- BUF
1 stop4h 58m
Delta
Deal found 4/20![Delta logo]()
$197
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:28 pm
BUF
- SAV
1 stop4h 25m
American Airlines
Wed 5/134:34 pm
SAV
- BUF
1 stop7h 16m
American Airlines
Deal found 4/22![American Airlines logo]()
$198
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:40 pm
BUF
- SAV
1 stop4h 24m
Delta
Wed 9/28:45 am
SAV
- BUF
1 stop6h 45m
Delta
Deal found 4/23![Delta logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- CHS
1 stop13h 46m
Multiple Airlines
Tue 6/210:38 am
CHS
- BUF
2 stops27h 16m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$200
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:04 am
BUF
- CHS
1 stop4h 35m
Delta
Thu 6/46:55 pm
CHS
- BUF
1 stop4h 37m
Delta
Deal found 4/20![Delta logo]()
$201
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Tue 5/194:25 pm
CHS
- BUF
1 stop6h 15m
American Airlines
Deal found 4/20![American Airlines logo]()
$204
Best flights from Buffalo to South CarolinaDiscover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
Discover carefully curated flight deals from Buffalo to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/610:34 am
BUF
- SAV
1 stop4h 09m
United Airlines
Tue 6/911:30 am
SAV
- BUF
1 stop5h 16m
United Airlines
Deal found 4/20![United Airlines logo]()
$195
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:27 pm
BUF
- SAV
1 stop4h 34m
Delta
Mon 6/156:14 pm
SAV
- BUF
1 stop6h 24m
Delta
Deal found 4/20![Delta logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/122:50 pm
BUF
- GSP
2 stops40h 39m
Multiple Airlines
Sun 6/218:19 am
GSP
- BUF
1 stop10h 53m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$274
This JetBlue deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/309:54 am
BUF
- CHS
1 stop8h 19m
JetBlue
Wed 6/37:20 pm
CHS
- BUF
1 stop4h 39m
JetBlue
Deal found 4/22![JetBlue logo]()
$293
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2011:00 am
BUF
- MYR
1 stop6h 30m
Southwest
Wed 6/247:05 pm
MYR
- BUF
1 stop3h 35m
Southwest
Deal found 4/19![Southwest logo]()
$317
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:36 am
BUF
- HHH
1 stop4h 50m
American Airlines
Sun 6/145:21 pm
HHH
- BUF
1 stop5h 15m
American Airlines
Deal found 4/19![American Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:39 pm
BUF
- CHS
1 stop4h 20m
Delta
Mon 6/16:03 pm
CHS
- BUF
1 stop5h 56m
Delta
Deal found 4/19![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:09 am
BUF
- CHS
1 stop4h 07m
United Airlines
Wed 6/311:31 am
CHS
- BUF
1 stop5h 15m
United Airlines
Deal found 4/20![United Airlines logo]()
$275
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:10 pm
BUF
- CAE
1 stop5h 07m
Delta
Tue 7/146:01 pm
CAE
- BUF
1 stop5h 58m
Delta
Deal found 4/19![Delta logo]()
$276
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:00 pm
BUF
- CLT
1 stop5h 30m
Southwest
Wed 5/206:40 am
CLT
- BUF
2 stops7h 55m
Southwest
Deal found 4/22![Southwest logo]()
$323
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
BUF
- CAE
2 stops8h 16m
United Airlines
Tue 6/22:29 pm
CAE
- BUF
1 stop6h 34m
United Airlines
Deal found 4/22![United Airlines logo]()
$294
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:30 pm
BUF
- MYR
1 stop7h 09m
Delta
Tue 8/186:45 pm
MYR
- BUF
1 stop5h 13m
Delta
Deal found 4/21![Delta logo]()
$277
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:00 am
BUF
- CLT
Nonstop2h 01m
American Airlines
Mon 7/204:26 pm
CLT
- BUF
1 stop4h 41m
American Airlines
Deal found 4/23![American Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:15 am
BUF
- MYR
1 stop4h 24m
Delta
Wed 6/311:32 am
MYR
- BUF
1 stop3h 40m
Delta
Deal found 4/21![Delta logo]()
$277
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:55 pm
BUF
- CHS
1 stop4h 00m
Southwest
Sun 6/78:05 pm
CHS
- BUF
1 stop3h 50m
Southwest
Deal found 4/21![Southwest logo]()
$338
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:45 pm
BUF
- SAV
1 stop4h 41m
United Airlines
Tue 5/127:15 pm
SAV
- BUF
1 stop4h 40m
United Airlines
Deal found 4/22![United Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:07 am
BUF
- CHS
1 stop6h 10m
Delta
Sat 7/184:20 pm
CHS
- BUF
1 stop4h 57m
Delta
Deal found 4/23![Delta logo]()
$278
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:40 am
BUF
- SAV
2 stops9h 55m
Southwest
Wed 9/98:00 am
SAV
- BUF
2 stops7h 15m
Southwest
Deal found 4/22![Southwest logo]()
$348
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:14 am
BUF
- HHH
2 stops10h 24m
American Airlines
Sun 9/65:46 pm
HHH
- BUF
1 stop4h 54m
American Airlines
Deal found 4/23![American Airlines logo]()
$383
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:00 am
BUF
- MYR
1 stop7h 12m
United Airlines
Wed 6/310:34 am
MYR
- BUF
1 stop3h 51m
United Airlines
Deal found 4/20![United Airlines logo]()
$331
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1011:00 am
BUF
- CLT
2 stops6h 40m
Southwest
Sat 6/131:00 pm
CLT
- BUF
2 stops7h 20m
Southwest
Deal found 4/22![Southwest logo]()
$359
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:00 am
BUF
- SAV
1 stop7h 16m
United Airlines
Wed 6/1711:30 am
SAV
- BUF
2 stops12h 29m
United Airlines
Deal found 4/21![United Airlines logo]()
$336
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:05 am
BUF
- HHH
1 stop5h 24m
Delta
Thu 7/94:12 pm
HHH
- BUF
1 stop7h 26m
Delta
Deal found 4/20![Delta logo]()
$311
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:17 pm
BUF
- GSP
1 stop4h 22m
American Airlines
Thu 7/97:52 am
GSP
- BUF
1 stop6h 27m
American Airlines
Deal found 4/18![American Airlines logo]()
$437
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:55 am
BUF
- MYR
2 stops8h 30m
Southwest
Sun 5/312:15 pm
MYR
- BUF
2 stops8h 50m
Southwest
Deal found 4/23![Southwest logo]()
$370
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:04 am
BUF
- SAV
2 stops9h 35m
United Airlines
Tue 5/267:15 pm
SAV
- BUF
1 stop4h 44m
United Airlines
Deal found 4/21![United Airlines logo]()
$337
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:04 am
BUF
- HHH
1 stop5h 33m
Delta
Wed 6/312:18 pm
HHH
- BUF
1 stop6h 26m
Delta
Deal found 4/20![Delta logo]()
$311
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/224:55 pm
BUF
- SAV
1 stop4h 05m
Delta
Tue 5/266:36 am
SAV
- BUF
1 stop4h 37m
Delta
Deal found 4/22![Delta logo]()
$312
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:50 am
BUF
- HHH
1 stop4h 19m
American Airlines
Sat 8/295:46 pm
HHH
- BUF
1 stop4h 54m
American Airlines
Deal found 4/20![American Airlines logo]()
$457
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:10 am
BUF
- HHH
2 stops9h 31m
United Airlines
Mon 5/113:08 pm
HHH
- BUF
2 stops8h 47m
United Airlines
Deal found 4/22![United Airlines logo]()
$349
Last-minute flights from Buffalo to South CarolinaDiscover last-minute flight deals from Buffalo to South Carolina. Data last updated April 24, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to South Carolina. Data last updated April 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/117:28 pm
BUF
- SAV
1 stop4h 25m
American Airlines
Wed 5/134:34 pm
SAV
- BUF
1 stop7h 16m
American Airlines
Deal found 4/22![American Airlines logo]()
$198
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:59 pm
BUF
- SAV
1 stop3h 54m
American Airlines
Sat 5/166:57 pm
SAV
- BUF
1 stop4h 52m
American Airlines
Deal found 4/20![American Airlines logo]()
$186
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:28 pm
BUF
- CHS
1 stop4h 31m
American Airlines
Tue 5/194:25 pm
CHS
- BUF
1 stop6h 15m
American Airlines
Deal found 4/20![American Airlines logo]()
$204
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2010:44 am
BUF
- SAV
1 stop7h 32m
American Airlines
Wed 5/277:30 pm
SAV
- BUF
1 stop4h 26m
American Airlines
Deal found 4/22![American Airlines logo]()
$171
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:30 am
BUF
- CHS
1 stop5h 07m
American Airlines
Wed 5/277:47 pm
CHS
- BUF
1 stop4h 09m
American Airlines
Deal found 4/22![American Airlines logo]()
$173
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:04 am
BUF
- SAV
2 stops9h 09m
United Airlines
Wed 5/273:14 pm
SAV
- BUF
1 stop5h 49m
United Airlines
Deal found 4/22![United Airlines logo]()
$194
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:29 pm
BUF
- CHS
1 stop4h 30m
American Airlines
Sat 5/304:43 pm
CHS
- BUF
1 stop5h 19m
American Airlines
Deal found 4/23![American Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:52 pm
BUF
- CHS
1 stop13h 46m
Multiple Airlines
Tue 6/210:38 am
CHS
- BUF
2 stops27h 16m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$200
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/274:55 pm
BUF
- CHS
1 stop7h 04m
Delta
Wed 6/36:15 am
CHS
- BUF
1 stop4h 58m
Delta
Deal found 4/20![Delta logo]()
$197
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:04 am
BUF
- CHS
1 stop4h 35m
Delta
Thu 6/46:55 pm
CHS
- BUF
1 stop4h 37m
Delta
Deal found 4/20![Delta logo]()
$201
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:39 pm
BUF
- CHS
1 stop4h 20m
Delta
Wed 6/36:15 am
CHS
- BUF
1 stop4h 58m
Delta
Deal found 4/20![Delta logo]()
$216
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:39 pm
BUF
- CHS
1 stop4h 20m
Delta
Thu 6/410:43 am
CHS
- BUF
1 stop5h 07m
Delta
Deal found 4/20![Delta logo]()
$220
One-way flights from Buffalo to South CarolinaSearch for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
Search for one-way flight options from Buffalo to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:41 pm
BUF
- CLT
1 stop23h 11m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$74
This CheapOair deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:52 pm
BUF
- CLT
1 stop20h 51m
Frontier
Deal found 4/20![Frontier logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/187:41 pm
BUF
- CHS
1 stop12h 57m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$86
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:32 pm
BUF
- CHS
1 stop5h 23m
American Airlines
Deal found 4/21![American Airlines logo]()
$87
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:52 pm
BUF
- CLT
1 stop16h 20m
Frontier
Deal found 4/21![Frontier logo]()
$91
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:04 am
BUF
- CHS
2 stops7h 47m
United Airlines
Deal found 4/22![United Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2312:41 pm
BUF
- CLT
2 stops10h 59m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$99
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:30 pm
BUF
- SAV
1 stop4h 23m
Delta
Deal found 4/23![Delta logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:52 pm
BUF
- CHS
1 stop12h 46m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$102
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:55 pm
BUF
- CHS
1 stop7h 04m
Delta
Deal found 4/22![Delta logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/912:41 pm
BUF
- CLT
2 stops31h 21m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$106
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am
BUF
- SAV
1 stop4h 10m
Southwest
Deal found 4/20![Southwest logo]()
$112
Find flight deals from Buffalo to South Carolina
Keep the following information in mind while searching for Buffalo to South Carolina flight deals. Data was last updated April 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $171 (American Airlines) |
One-way from | $74 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $425 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Buffalo to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Sat 6/6
10:34 am-2:43 pm
1 stop4h 09m
Savannah/Hilton Head
Tue 6/9
11:30 am-4:46 pm
1 stop5h 16m
$195
BuffaloSavannah
BUF - SAV
BUFSAV
Buffalo
Thu 6/11
7:27 pm-12:01 am
1 stop4h 34m
Savannah/Hilton Head
Mon 6/15
6:14 pm-12:38 am
1 stop6h 24m
$251
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Fri 5/29
7:39 pm-11:59 pm
1 stop4h 20m
Charleston
Mon 6/1
6:03 pm-11:59 pm
1 stop5h 56m
$257
BuffaloGreenville
BUF - GSP
BUFGSP
Buffalo
Fri 6/12
2:50 pm-7:29 am
2 stops40h 39m
Greenville
Sun 6/21
8:19 am-7:12 pm
1 stop10h 53m
$274
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 5/30
6:09 am-10:16 am
1 stop4h 07m
Charleston
Wed 6/3
11:31 am-4:46 pm
1 stop5h 15m
$275
BuffaloColumbia
BUF - CAE
BUFCAE
Buffalo
Fri 7/10
6:10 pm-11:17 pm
1 stop5h 07m
Columbia Metropolitan
Tue 7/14
6:01 pm-11:59 pm
1 stop5h 58m
$276
BuffaloMyrtle Beach
BUF - MYR
BUFMYR
Buffalo
Thu 8/13
4:30 pm-11:39 pm
1 stop7h 09m
Myrtle Beach Intl
Tue 8/18
6:45 pm-11:58 pm
1 stop5h 13m
$277
BuffaloMyrtle Beach
BUF - MYR
BUFMYR
Buffalo
Thu 5/28
6:15 am-10:39 am
1 stop4h 24m
Myrtle Beach Intl
Wed 6/3
11:32 am-3:12 pm
1 stop3h 40m
$277
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Wed 7/15
6:07 am-12:17 pm
1 stop6h 10m
Charleston
Sat 7/18
4:20 pm-9:17 pm
1 stop4h 57m
$278
BuffaloCharleston
BUF - CHS
BUFCHS
Buffalo
Sat 5/30
9:54 am-6:13 pm
1 stop8h 19m
Charleston
Wed 6/3
7:20 pm-11:59 pm
1 stop4h 39m
$293
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Buffalo to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Buffalo with our price prediction graph.
BUF-SAV
BUF-CHS
BUF-GSP
BUF-MYR
BUF-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to South Carolina
BUF-USSC
BUF-SAV
BUF-CHS
BUF-GSP
BUF-MYR
How far ahead should I book a flight from Buffalo to South Carolina?
The price you pay for your flight from Buffalo to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 69 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Buffalo to South Carolina?
Currently, June is the cheapest month in which you can book a flight from Buffalo to South Carolina (average of $80). Flying from Buffalo to South Carolina in January is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Buffalo to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 24, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Buffalo to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Entertainment
7.5
Food
7.0
Crew
8.6
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Buffalo to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Buffalo and South Carolina flights
Browse other Buffalo and South Carolina flight options. Last updated on April 24, 2026.
Popular flight searches
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Buffalo to South Carolina flights
Consider these flights traveling from Buffalo to South Carolina.
Top 5 airlines flying from Buffalo to South Carolina
Discover the top 5 airlines that operate flights from Buffalo to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$80 | Average$232 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$108 | Average$334 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$352 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$200 | Average$279 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$409 | FlexibilityNo cancel fee | On-time63% |