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Santo Domingo

$172+ Cheap flights from San Francisco (SFO) to Santo Domingo (SDQ)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SDQ
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Santo Domingo Las Americas are usually found in September or October, booked 27 days in advance, depart on a Tuesday or Thursday and return on a Thursday

Cheap flight deals from San Francisco to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$393
(Expedia)

One-way from

$172
(SmartFares)

Popular in

December

Cheapest in

September

Average price

$561
From San Francisco to Santo Domingo Las Americas
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One-way flight from San Francisco to Santo Domingo Las Americas
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Highest demand for flights based on searches. 11% potential increase in price ($91 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from San Francisco to Santo Domingo

Cheapest flights from San Francisco to Santo Domingo
Explore the most affordable flight options available from San Francisco to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/39:44 pmSFO - SDQ
1 stop12h 47mJetBlue
Wed 11/123:45 pmSDQ - SFO
1 stop11h 46mJetBlue
Deal found 9/10$393
This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:20 pmSFO - SDQ
1 stop10h 57mJetBlue
Sat 11/12:30 pmSDQ - SFO
1 stop12h 01mJetBlue
Deal found 9/10$402
This JetBlue deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:43 pmSFO - SDQ
1 stop13h 48mJetBlue
Tue 11/43:45 pmSDQ - SFO
1 stop11h 46mJetBlue
Deal found 9/10$413
This Expedia deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/269:44 pmSFO - SDQ
1 stop12h 33mJetBlue
Thu 11/63:45 pmSDQ - SFO
1 stop11h 46mJetBlue
Deal found 9/11$422
This CheapOair deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/110:35 amSFO - SDQ
1 stop23h 49mJetBlue
Wed 10/82:54 pmSDQ - SFO
1 stop11h 22mJetBlue
Deal found 9/10$431
This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/512:10 pmSFO - SDQ
1 stop11h 30mJetBlue
Mon 11/103:45 pmSDQ - SFO
1 stop22h 20mJetBlue
Deal found 9/10$434
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/71:31 amSFO - SDQ
1 stop11h 44mCopa Airlines
Tue 10/212:10 pmSDQ - SFO
1 stop12h 29mCopa Airlines
Deal found 9/10$439
This Expedia deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:20 pmSFO - SDQ
1 stop11h 23mJetBlue
Wed 10/292:30 pmSDQ - SFO
1 stop12h 01mJetBlue
Deal found 9/11$441
This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/79:00 pmSFO - SDQ
1 stop11h 22mJetBlue
Tue 10/142:54 pmSDQ - SFO
1 stop11h 22mJetBlue
Deal found 9/10$451
This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/511:30 amSFO - SDQ
1 stop10h 23mJetBlue
Tue 11/113:45 pmSDQ - SFO
1 stop11h 46mJetBlue
Deal found 9/10$453

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from San Francisco to Santo Domingo that are best for you.

Fly from

San Francisco

Fly to

Santo Domingo

Route

Depart

Return

Price

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sat 11/1

9:43 pm-2:31 pm

1 stop13h 48m

Santo Domingo Las Americas

Tue 11/4

3:45 pm-11:31 pm

1 stop11h 46m

$413

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 10/1

10:35 am-1:24 pm

1 stop23h 49m

Santo Domingo Las Americas

Wed 10/8

2:54 pm-11:16 pm

1 stop11h 22m

$431

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 11/5

12:10 pm-3:40 am

1 stop11h 30m

Santo Domingo Las Americas

Mon 11/10

3:45 pm-10:05 am

1 stop22h 20m

$434

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 10/7

1:31 am-4:15 pm

1 stop11h 44m

Santo Domingo Las Americas

Tue 10/21

2:10 pm-11:39 pm

1 stop12h 29m

$439

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 10/7

9:00 pm-11:22 am

1 stop11h 22m

Santo Domingo Las Americas

Tue 10/14

2:54 pm-11:16 pm

1 stop11h 22m

$451

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Mon 10/6

1:31 am-4:15 pm

1 stop11h 44m

Santo Domingo Las Americas

Tue 10/14

2:10 pm-11:39 pm

1 stop12h 29m

$457

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Sat 10/25

10:23 pm-2:01 pm

1 stop12h 38m

Santo Domingo Las Americas

Sat 11/1

3:59 pm-1:15 pm

2 stops24h 16m

$466

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 10/7

2:20 pm-5:15 pm

2 stops23h 55m

Santo Domingo Las Americas

Tue 10/14

6:10 pm-12:35 pm

2 stops21h 25m

$487

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Tue 9/30

2:20 pm-5:15 pm

2 stops23h 55m

Santo Domingo Las Americas

Thu 10/9

11:45 am-10:45 pm

2 stops14h 00m

$487

San FranciscoSanto Domingo

SFO - SDQ

SFOSDQ

San Francisco

Wed 10/15

2:20 pm-5:15 pm

2 stops23h 55m

Santo Domingo Las Americas

Wed 10/22

6:10 pm-12:35 pm

2 stops21h 25m

$487

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 21 results
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Best time to book a flight from San Francisco to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santo Domingo

How far ahead should I book a flight from San Francisco to Santo Domingo?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santo Domingo. Price data was last updated on August 29, 2025.

The price you pay for your flight from San Francisco to Santo Domingo may vary depending on when you book. For the best chance of a lower fare, look to book 27 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from San Francisco to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Santo Domingo (average of $362). Flying from San Francisco to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SDQ?

Find hourly flight availability from San Francisco to Santo Domingo. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

It’s typically best to fly out from San Francisco to Santo Domingo in the afternoon. Doing so could potentially save you 18% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from San Francisco to Santo Domingo?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to Santo Domingo. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Francisco to Santo Domingo flight should consider departing on Friday afternoons when fares are most often at their lowest. Wednesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from San Francisco to Santo Domingo, such as Delta, Copa Airlines, and Aeromexico. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,531 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Aeromexico
7.5
Good
1,701 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
JetBlue
7.2
Good
2,913 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Santo Domingo?

    There are many flights that can get you from San Francisco to Santo Domingo in 11h 44m. Fly via JetBlue or Copa Airlines to get the fastest option. Airlines will cover a distance of 3424 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from San Francisco to Santo Domingo round-trip?

    Currently priced at $378, Aeromexico will fly you from San Francisco to Santo Domingo and back. In addition to Aeromexico, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from JetBlue and Avianca - these airlines can fly you to your destination from $447 and $487, respectively. Aeromexico is 44% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from San Francisco to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santo Domingo.

  • Can I find deals for business class flights from San Francisco to Santo Domingo?

    Yes. Cheapflights offers flight deals from San Francisco to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from San Francisco to Santo Domingo (average of $362). Flying from San Francisco to Santo Domingo in December is currently the most expensive (average of $583). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for San Francisco to Santo Domingo

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Long Beach to Santo Domingo flights

Top 6 airlines flying from San Francisco to Santo Domingo

Discover the top 6 airlines that operate flights from San Francisco to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$378Average$735FlexibilityNo cancel feeOn-timeN/A
JetBlueCheapest$447Average$673FlexibilityNo cancel feeOn-time62%
AviancaCheapest$487Average$584FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$497Average$598FlexibilityNo cancel feeOn-time70%
DeltaCheapest$543Average$731FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$619Average$766FlexibilityNo cancel feeOn-time71%

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