$292+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/1. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SFO
Nov 21 — Nov 281
Round-trip
1 adult, Economy
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Find cheap flights from Santo Domingo to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santo Domingo to San Francisco
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One-way
Cheapest flights from Santo Domingo to San FranciscoExplore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2026.
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2026.
This Mytrip deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:19 am -
3 stops40h 10m
Sun 11/1510:20 pm -
2 stops14h 46m
Deal found 10/20![Multiple Airlines logo]()
$629
This Mytrip deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:19 am -
3 stops40h 10m
Mon 11/1610:20 pm -
2 stops19h 25m
Deal found 10/20![Multiple Airlines logo]()
$633
This Justfly.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:45 pm -
2 stops27h 10m
Tue 12/81:15 pm -
2 stops18h 35m
Deal found 10/20![Avianca logo]()
$645
This FlightHub deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:45 pm -
2 stops36h 55m
Sun 11/151:15 pm -
2 stops42h 35m
Deal found 10/20![Avianca logo]()
$672
This Sembo deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Sembo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/258:55 am -
1 stop12h 30m
Wed 1/137:36 pm -
1 stop11h 25m
Deal found 10/21![Copa Airlines logo]()
$678
This FlightHub deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:45 pm -
2 stops36h 50m
Mon 10/262:15 pm -
2 stops18h 35m
Deal found 10/18![Avianca logo]()
$683
Best flights from Santo Domingo to San FranciscoDiscover carefully curated flight deals from Santo Domingo to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 22, 2026.
Discover carefully curated flight deals from Santo Domingo to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 22, 2026.
This Avianca deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/246:45 pm -
2 stops21h 10m
Sun 1/3111:00 pm -
2 stops14h 50m
Deal found 10/19![Avianca logo]()
$600
This Copa Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/247:05 pm -
1 stop26h 20m
Sun 1/317:36 pm -
1 stop26h 28m
Deal found 10/18![Copa Airlines logo]()
$609
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am -
1 stop16h 20m
Wed 12/912:04 pm -
1 stop18h 01m
Deal found 10/17![American Airlines logo]()
$842
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
1 stop13h 23m
Thu 11/2610:50 pm -
1 stop12h 16m
Deal found 10/20![United Airlines logo]()
$883
This Justfly.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:45 pm -
2 stops27h 10m
Tue 12/81:15 pm -
2 stops18h 35m
Deal found 10/18![Avianca logo]()
$645
This Sembo deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Sembo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/258:55 am -
1 stop12h 30m
Wed 1/137:36 pm -
1 stop11h 25m
Deal found 10/21![Copa Airlines logo]()
$678
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:18 pm -
1 stop25h 17m
Fri 12/1111:59 pm -
1 stop19h 47m
Deal found 10/19![United Airlines logo]()
$904
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:09 am -
1 stop15h 44m
Tue 12/812:04 pm -
1 stop19h 51m
Deal found 10/21![American Airlines logo]()
$908
Last-minute flights from Santo Domingo to San FranciscoDiscover last-minute flight deals from Santo Domingo to San Francisco. Data last updated October 22, 2026 and is based on user searches.
Discover last-minute flight deals from Santo Domingo to San Francisco. Data last updated October 22, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:19 am -
3 stops40h 10m
Sun 11/1510:20 pm -
2 stops14h 46m
Deal found 10/20![Multiple Airlines logo]()
$629
This Mytrip deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:19 am -
3 stops40h 10m
Mon 11/1610:20 pm -
2 stops19h 25m
Deal found 10/20![Multiple Airlines logo]()
$633
This FlightHub deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:45 pm -
2 stops36h 55m
Sun 11/151:15 pm -
2 stops42h 35m
Deal found 10/20![Avianca logo]()
$672
This Justfly.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:45 pm -
2 stops27h 10m
Tue 12/81:15 pm -
2 stops18h 35m
Deal found 10/20![Avianca logo]()
$645
One-way flights from Santo Domingo to San FranciscoSearch for one-way flight options from Santo Domingo to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 22, 2026.
Search for one-way flight options from Santo Domingo to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/110:56 am -
3 stops29h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:19 am -
2 stops16h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/213:09 pm -
3 stops45h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/123:30 pm -
3 stops32h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Multiple Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:19 am -
2 stops28h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:35 pm -
2 stops23h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$348
This Avianca deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/26:45 pm -
2 stops21h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Avianca logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:56 am -
2 stops28h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:30 am -
2 stops19h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:02 pm -
2 stops35h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/810:56 am -
3 stops34h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Multiple Airlines logo]()
$373
Find flight deals from Santo Domingo to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $598 (Avianca) |
One-way from | $292 (Kiwi.com) |
Popular in | July |
Cheapest in | January |
Average price | $644 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 22, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Sun 2/21
3:09 pm-8:49 am
3 stops45h 40m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$335
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Tue 2/2
6:45 pm-11:55 am
2 stops21h 10m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$353
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Mon 11/2
10:56 am-11:17 am
2 stops28h 21m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$356
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Fri 1/22
12:45 pm-11:55 am
2 stops27h 10m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$377
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Mon 2/8
6:45 pm-9:40 pm
2 stops30h 55m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$377
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Sun 1/31
12:45 pm-9:40 pm
2 stops36h 55m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$396
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Fri 1/22
10:58 am-11:59 pm
1 stop17h 01m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$416
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Sun 1/10
5:10 am-9:00 am
3 stops31h 50m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$430
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Mon 2/8
6:00 am-8:54 pm
1 stop18h 54m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$440
Quickest round-trip
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Mon 12/21
6:00 am-4:19 pm
2 stops14h 19m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$444
Showing 1-10 of 18 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santo Domingo to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.
SDQ-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santo Domingo to San Francisco
What is the cheapest month to book a flight from Santo Domingo to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $557). Flying from Santo Domingo to San Francisco in July is currently the most expensive (average of $1,487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santo Domingo to San Francisco?
Airfare is typical for this route at the moment.
Santo Domingo to San Francisco flights typically cost between $588 and $768 in January.The cheapest round-trip price found within the last 5 days was $598 on Avianca (Jan 24-Jan 31).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 22, 2026.
Peruse reviews from past customers who have flown with JetBlue and American Airlines from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.3
Overall
7.1
Crew
7.9
Entertainment
7.1
Food
6.6
Comfort
7.4
Reviews
1 / 20
4.0
OkayAnonymous,Feb 2025
BOS - SFO
Boarding
7.3
Overall
7.1
Crew
7.9
Entertainment
7.1
Food
6.6
Comfort
7.4
Reviews
1 / 20
4.0
OkayAnonymous,Feb 2025
BOS - SFO
Boarding
7.3
Overall
7.1
Crew
7.9
Entertainment
7.1
Food
6.6
Comfort
7.4
Reviews
1 / 20
4.0
OkayAnonymous,Feb 2025
BOS - SFO
Related info for your journey
Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Hayward
San Bruno
Emeryville
Newark
Burlingame
Roseville
Redwood City
Rancho Cordova
Cupertino
Fairfield
San Ramon
Manteca
San Carlos
Vallejo
Turlock
Davis
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Santo Domingo and San Francisco flights
Browse other Santo Domingo and San Francisco flight options. Last updated on October 22, 2026.
Other flights from Santo Domingo
Browse through other flights departing from Santo Domingo. Flights are based on user searches made on Cheapflights and were last updated on October 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 22, 2026.
Top 2 airlines flying from Santo Domingo to San Francisco
Discover the top 2 airlines that operate flights from Santo Domingo to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$456 | Average$578 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$634 | Average$811 | FlexibilityNo cancel fee | On-time71% |