$287+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SFO
Nov 10 — Nov 171
Round-trip
1 adult, Economy
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Find cheap flights from Santo Domingo to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santo Domingo to San Francisco
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One-way
Cheapest flights from Santo Domingo to San FranciscoExplore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 11, 2026.
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 11, 2026.
This Avianca deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:45 pm -
2 stops21h 10m
Tue 12/811:00 pm -
2 stops14h 50m
Deal found 10/8![Avianca logo]()
$598
This Avianca deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:45 pm -
2 stops21h 10m
Sun 11/2911:00 pm -
2 stops14h 50m
Deal found 10/7![Avianca logo]()
$633
This Mytrip deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:02 pm -
2 stops21h 15m
Thu 11/1210:20 pm -
2 stops14h 09m
Deal found 10/6![Multiple Airlines logo]()
$643
This Justfly.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:45 pm -
2 stops36h 55m
Sun 11/111:00 pm -
2 stops38h 50m
Deal found 10/8![Avianca logo]()
$655
This Expedia deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1412:45 pm -
2 stops38h 10m
Wed 10/212:15 pm -
2 stops24h 40m
Deal found 10/10![Avianca logo]()
$683
This Avianca deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:45 pm -
2 stops36h 55m
Mon 11/911:00 pm -
2 stops14h 50m
Deal found 10/7![Avianca logo]()
$692
This Priceline deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:45 pm -
2 stops36h 55m
Sun 11/111:30 am -
1 stop10h 16m
Deal found 10/8![Multiple Airlines logo]()
$740
Best flights from Santo Domingo to San FranciscoDiscover carefully curated flight deals from Santo Domingo to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 11, 2026.
Discover carefully curated flight deals from Santo Domingo to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 11, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/118:54 am -
1 stop18h 23m
Sun 2/147:36 pm -
1 stop26h 28m
Deal found 10/8![Copa Airlines logo]()
$597
This Avianca deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:45 pm -
2 stops21h 10m
Tue 12/811:00 pm -
2 stops14h 50m
Deal found 10/9![Avianca logo]()
$598
This Copa Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/247:05 pm -
1 stop26h 20m
Sun 1/317:36 pm -
1 stop26h 28m
Deal found 10/10![Copa Airlines logo]()
$597
This Avianca deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/246:45 pm -
2 stops21h 10m
Sun 1/311:15 pm -
2 stops18h 35m
Deal found 10/9![Avianca logo]()
$598
This Copa Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:02 pm -
1 stop26h 23m
Sun 2/77:36 pm -
1 stop13h 30m
Deal found 10/9![Copa Airlines logo]()
$597
This Avianca deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:45 pm -
2 stops36h 55m
Mon 11/911:00 pm -
2 stops14h 50m
Deal found 10/10![Avianca logo]()
$692
This Copa Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:57 am -
1 stop17h 43m
Wed 11/1112:33 am -
1 stop18h 25m
Deal found 10/7![Copa Airlines logo]()
$745
Last-minute flights from Santo Domingo to San FranciscoDiscover last-minute flight deals from Santo Domingo to San Francisco. Data last updated October 11, 2026 and is based on user searches.
Discover last-minute flight deals from Santo Domingo to San Francisco. Data last updated October 11, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1412:45 pm -
2 stops38h 10m
Wed 10/212:15 pm -
2 stops24h 40m
Deal found 10/10![Avianca logo]()
$683
This Mytrip deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:02 pm -
2 stops21h 15m
Thu 11/1210:20 pm -
2 stops14h 09m
Deal found 10/6![Multiple Airlines logo]()
$643
This Justfly.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:45 pm -
2 stops36h 55m
Sun 11/111:00 pm -
2 stops38h 50m
Deal found 10/8![Avianca logo]()
$655
This Priceline deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2912:45 pm -
2 stops36h 55m
Sun 11/111:30 am -
1 stop10h 16m
Deal found 10/8![Multiple Airlines logo]()
$740
This Avianca deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:45 pm -
2 stops36h 55m
Mon 11/911:00 pm -
2 stops14h 50m
Deal found 10/7![Avianca logo]()
$692
This Avianca deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:45 pm -
2 stops21h 10m
Tue 12/811:00 pm -
2 stops14h 50m
Deal found 10/8![Avianca logo]()
$598
This Avianca deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:45 pm -
2 stops21h 10m
Sun 11/2911:00 pm -
2 stops14h 50m
Deal found 10/7![Avianca logo]()
$633
One-way flights from Santo Domingo to San FranciscoSearch for one-way flight options from Santo Domingo to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 11, 2026.
Search for one-way flight options from Santo Domingo to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:30 am -
3 stops52h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/63:30 pm -
3 stops46h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$320
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/61:27 pm -
2 stops30h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Frontier logo]()
$324
This Avianca deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:50 pm -
2 stops21h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Avianca logo]()
$353
This FlightHub deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2212:45 pm -
2 stops27h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Avianca logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/193:35 pm -
3 stops25h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/83:09 pm -
3 stops52h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$386
This FlightHub deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:45 pm -
2 stops45h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![Avianca logo]()
$387
Find flight deals from Santo Domingo to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $597 (Copa Airlines) |
One-way from | $287 (Kiwi.com) |
Popular in | July |
Cheapest in | January |
Average price | $634 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 11, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Fri 10/23
12:45 pm-11:55 pm
2 stops38h 10m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$396
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Tue 1/19
7:33 pm-11:15 am
1 stop19h 42m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$405
Quickest round-trip
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Mon 12/21
6:00 am-7:24 pm
1 stop17h 24m
San Francisco
Wed 12/31
12:00 am-3:30 am
Nonstop0h 00m
$440
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Thu 2/11
8:54 am-11:17 pm
1 stop18h 23m
San Francisco
Sun 2/14
7:36 pm-2:04 am
1 stop26h 28m
$597
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Sun 1/24
7:05 pm-5:25 pm
1 stop26h 20m
San Francisco
Sun 1/31
7:36 pm-2:04 am
1 stop26h 28m
$597
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Mon 2/1
7:02 pm-5:25 pm
1 stop26h 23m
San Francisco
Sun 2/7
7:36 pm-1:06 pm
1 stop13h 30m
$597
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Sun 11/22
6:45 pm-11:55 am
2 stops21h 10m
San Francisco
Tue 12/8
11:00 pm-5:50 pm
2 stops14h 50m
$598
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Sun 1/24
6:45 pm-11:55 am
2 stops21h 10m
San Francisco
Sun 1/31
1:15 pm-11:50 am
2 stops18h 35m
$598
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Thu 11/5
12:45 pm-9:40 pm
2 stops36h 55m
San Francisco
Mon 11/9
11:00 pm-5:50 pm
2 stops14h 50m
$692
Santo DomingoSan Francisco
SDQ Santo Domingo Las Americas - SFO San Francisco
SDQSFO
Santo Domingo Las Americas
Thu 10/29
8:57 am-11:40 pm
1 stop17h 43m
San Francisco
Wed 11/11
12:33 am-10:58 pm
1 stop18h 25m
$745
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santo Domingo to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.
SDQ-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santo Domingo to San Francisco
What is the cheapest month to book a flight from Santo Domingo to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $557). Flying from Santo Domingo to San Francisco in July is currently the most expensive (average of $1,487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Santo Domingo to San Francisco?
Airfare is typical for this route at the moment.
Santo Domingo to San Francisco flights typically cost between $531 and $780 in January.The cheapest round-trip price found within the last 5 days was $597 on Copa Airlines (Jan 24-Jan 31).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 11, 2026.
Peruse reviews from past customers who have flown with JetBlue and American Airlines from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.6
Crew
7.9
Entertainment
7.2
Boarding
7.3
Comfort
7.4
Overall
7.1
Reviews
1 / 20
4.0
OkayAnonymous,Feb 2025
BOS - SFO
Food
6.6
Crew
7.9
Entertainment
7.2
Boarding
7.3
Comfort
7.4
Overall
7.1
Reviews
1 / 20
4.0
OkayAnonymous,Feb 2025
BOS - SFO
Food
6.6
Crew
7.9
Entertainment
7.2
Boarding
7.3
Comfort
7.4
Overall
7.1
Reviews
1 / 20
4.0
OkayAnonymous,Feb 2025
BOS - SFO
Related info for your journey
Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Hayward
San Bruno
Emeryville
Burlingame
Roseville
Redwood City
Rancho Cordova
Cupertino
Newark
Fairfield
San Ramon
Manteca
San Carlos
Vallejo
Turlock
Davis
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Santo Domingo and San Francisco flights
Browse other Santo Domingo and San Francisco flight options. Last updated on October 11, 2026.
Other flights from Santo Domingo
Browse through other flights departing from Santo Domingo. Flights are based on user searches made on Cheapflights and were last updated on October 11, 2026.
Popular flight searches
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Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 11, 2026.
Top 2 airlines flying from Santo Domingo to San Francisco
Discover the top 2 airlines that operate flights from Santo Domingo to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$456 | Average$564 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$634 | Average$811 | FlexibilityNo cancel fee | On-time71% |