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$288+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SFO
Jul 12 — Jul 191
Sun 7/12
Sun 7/19
1 adult, Economy
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Cheap flight deals from Santo Domingo to San Francisco

Cheapest flights from Santo Domingo to San Francisco
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.

This Copa Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:47 am
SDQ
-
SFO
1 stop12h 23m
Copa Airlines
Sun 9/278:21 pm
SFO
-
SDQ
1 stop12h 21m
Copa Airlines
Deal found 6/7$580
This Faresmojo deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:44 pm
SDQ
-
SFO
1 stop10h 06m
JetBlue
Tue 8/1810:57 am
SFO
-
SDQ
1 stop10h 02m
JetBlue
Deal found 6/11$611
This Copa Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:12 pm
SDQ
-
SFO
1 stop14h 28m
Copa Airlines
Fri 10/21:12 am
SFO
-
SDQ
1 stop22h 13m
Copa Airlines
Deal found 6/8$651
This Faresmojo deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:34 pm
SDQ
-
SFO
1 stop13h 16m
JetBlue
Wed 8/1910:57 am
SFO
-
SDQ
1 stop25h 24m
JetBlue
Deal found 6/11$654
This JetBlue deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:28 pm
SDQ
-
SFO
1 stop13h 02m
JetBlue
Tue 11/106:00 am
SFO
-
SDQ
1 stop14h 53m
JetBlue
Deal found 6/9$666
This JetBlue deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:44 pm
SDQ
-
SFO
1 stop10h 06m
JetBlue
Mon 8/3110:40 pm
SFO
-
SDQ
1 stop10h 44m
JetBlue
Deal found 6/9$686
This Trip.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:02 pm
SDQ
-
SFO
2 stops18h 46m
Multiple Airlines
Mon 8/312:29 am
SFO
-
SDQ
2 stops18h 16m
Multiple Airlines
Deal found 6/10$719
This Orbitz deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:38 pm
SDQ
-
SFO
1 stop10h 13m
JetBlue
Tue 8/48:25 pm
SFO
-
SDQ
2 stops15h 58m
JetBlue
Deal found 6/9$722
This Copa Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/92:17 pm
SDQ
-
SFO
1 stop12h 23m
Copa Airlines
Mon 8/31:12 am
SFO
-
SDQ
1 stop18h 44m
Copa Airlines
Deal found 6/10$726
This SmartFares deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:01 am
SDQ
-
SFO
1 stop21h 50m
JetBlue
Wed 7/2910:40 pm
SFO
-
SDQ
1 stop22h 19m
JetBlue
Deal found 6/10$729

Find flight deals from Santo Domingo to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$580
(Copa Airlines)

One-way from

$288
(Faresmojo)

Popular in

June

Cheapest in

October

Average price

$1,055
Provider with most accurate pricing for Santo Domingo Las Americas-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-San Francisco flights.
Search Deals
From Santo Domingo Las Americas to San Francisco
Search Deals
One-way flight from Santo Domingo Las Americas to San Francisco
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($136 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Wed 9/23

8:47 am-6:10 pm

1 stop12h 23m

San Francisco

Sun 9/27

8:21 pm-11:42 am

1 stop12h 21m

$580

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 9/24

2:16 pm-11:40 pm

1 stop12h 24m

San Francisco

Fri 10/2

1:12 am-2:25 am

1 stop22h 13m

$651

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 8/14

1:34 pm-11:50 pm

1 stop13h 16m

San Francisco

Wed 8/19

10:57 am-3:21 pm

1 stop25h 24m

$654

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 10/29

1:28 pm-11:30 pm

1 stop13h 02m

San Francisco

Tue 11/10

8:55 pm-2:10 pm

1 stop13h 15m

$666
Quickest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 8/27

4:44 pm-11:50 pm

1 stop10h 06m

San Francisco

Mon 8/31

10:40 pm-12:24 pm

1 stop10h 44m

$736
Cheapest one-way

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 7/6

6:50 pm-12:50 pm

2 stops21h 00m

$393

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 10/23

6:50 pm-12:50 pm

2 stops21h 00m

$393

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 11/26

12:20 pm-9:50 pm

2 stops37h 30m

$416

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 7/10

5:01 am-9:48 am

1 stop31h 47m

$434

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 7/4

6:00 am-7:25 pm

1 stop16h 25m

$447

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 15 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to San Francisco

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

Currently, October is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $544). Flying from Santo Domingo to San Francisco in June is currently the most expensive (average of $1,055). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Santo Domingo to San Francisco?

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated June 12, 2026.
Peruse reviews from past customers who have flown with JetBlue from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
JetBlue
7.1
Good
2,981 reviews

Crew

7.9

Food

6.6

Comfort

7.5

Entertainment

7.2

Boarding

7.3

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Dave,Jun 2026

MCO - ROC

When i book 2 tickets they should keep them together even though I can't choose a seat
JetBlue
7.1
Good
2,981 reviews
JetBlue
7.1
Good
2,981 reviews

Crew

7.9

Food

6.6

Comfort

7.5

Entertainment

7.2

Boarding

7.3

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Dave,Jun 2026

MCO - ROC

When i book 2 tickets they should keep them together even though I can't choose a seat

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to San Francisco?

    A quick flight from Santo Domingo to San Francisco can take about 21h 17m. Copa Airlines provides one of the quickest options available for as low as $607. Santo Domingo and San Francisco are separated by a distance of 3424 mi.

  • What is the cheapest airline to fly from Santo Domingo to San Francisco round-trip?

    Our cheapest airline available from Santo Domingo to San Francisco is JetBlue. Our recent data shows that you can find tickets from as low as $458 on this airline. JetBlue is currently priced 32% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Santo Domingo to San Francisco one-way?

    For one-way options, check prices for JetBlue. According to our data, you can fly for as low as $177. Users have also found prices from $334 and $347 on Delta and Aeromexico, respectively.

  • Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to San Francisco.

  • Can I find deals for business class flights from Santo Domingo to San Francisco?

    Yes. Cheapflights offers flight deals from Santo Domingo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to San Francisco?

    Currently, October is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $544). Flying from Santo Domingo to San Francisco in June is currently the most expensive (average of $1,055). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
Roseville
Cupertino
Emeryville
Newark
San Bruno
Watsonville
San Ramon
Vacaville
San Carlos
Redwood City
Daly City
Sunnyvale
Turlock
Vallejo
San Lorenzo

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Santo Domingo to San Francisco

Discover the top airline that operate flights from Santo Domingo to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$458Average$564FlexibilityNo cancel feeOn-time62%

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