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$304+ Cheap flights from Santo Domingo (SDQ) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
SDQ — SFO
Aug 22 — Aug 291
Sat 8/22
Sat 8/29
1 adult, Economy
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Cheap flight deals from Santo Domingo to San Francisco

Cheapest flights from Santo Domingo to San Francisco
Explore the most affordable flight options available from Santo Domingo to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.

This JetBlue deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/243:59 pm
SDQ
-
SFO
1 stop10h 20m
JetBlue
Sun 9/2711:10 pm
SFO
-
SDQ
1 stop11h 09m
JetBlue
Deal found 7/21$588
This JetBlue deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/223:59 pm
SDQ
-
SFO
1 stop10h 18m
JetBlue
Wed 9/2311:10 pm
SFO
-
SDQ
1 stop11h 09m
JetBlue
Deal found 7/21$599
This JetBlue deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:44 pm
SDQ
-
SFO
1 stop10h 07m
JetBlue
Thu 11/56:00 am
SFO
-
SDQ
1 stop16h 54m
JetBlue
Deal found 7/21$602
This Cheapflightsfares deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:29 pm
SDQ
-
SFO
1 stop11h 50m
JetBlue
Sat 10/310:10 pm
SFO
-
SDQ
1 stop14h 15m
JetBlue
Deal found 7/22$607
This Avianca deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:50 pm
SDQ
-
SFO
2 stops21h 00m
Avianca
Thu 10/222:15 pm
SFO
-
SDQ
2 stops18h 35m
Avianca
Deal found 7/23$614
This SmartFares deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/412:45 pm
SDQ
-
SFO
2 stops36h 50m
Avianca
Fri 9/112:15 pm
SFO
-
SDQ
2 stops18h 35m
Avianca
Deal found 7/22$653
This Expedia deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:35 pm
SDQ
-
SFO
1 stop13h 16m
JetBlue
Fri 9/1110:24 am
SFO
-
SDQ
1 stop25h 25m
JetBlue
Deal found 7/22$658
This Justfly.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:45 pm
SDQ
-
SFO
2 stops36h 50m
Avianca
Sat 10/311:55 pm
SFO
-
SDQ
2 stops39h 00m
Avianca
Deal found 7/22$661
This Copa Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1812:12 pm
SDQ
-
SFO
1 stop14h 28m
Copa Airlines
Thu 10/228:21 pm
SFO
-
SDQ
1 stop23h 35m
Copa Airlines
Deal found 7/20$668
This JetBlue deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:28 pm
SDQ
-
SFO
1 stop13h 02m
JetBlue
Thu 12/108:00 am
SFO
-
SDQ
1 stop12h 51m
JetBlue
Deal found 7/22$673
This Cheapflightsfares deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:29 pm
SDQ
-
SFO
1 stop11h 50m
JetBlue
Thu 10/2210:30 am
SFO
-
SDQ
1 stop10h 29m
JetBlue
Deal found 7/22$677
This Expedia deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/44:44 pm
SDQ
-
SFO
1 stop10h 07m
Multiple Airlines
Fri 9/112:50 pm
SFO
-
SDQ
1 stop12h 56m
Multiple Airlines
Deal found 7/22$689

Find flight deals from Santo Domingo to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santo Domingo (SDQ) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$588
(JetBlue)

One-way from

$309
(Kiwi.com)

Popular in

July

Cheapest in

March

Average price

$1,487
Provider with most accurate pricing for Santo Domingo Las Americas-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santo Domingo Las Americas-San Francisco flights.
Search Deals
From Santo Domingo Las Americas to San Francisco
Search Deals
One-way flight from Santo Domingo Las Americas to San Francisco
Search Deals
Highest demand for flights based on searches. 34% potential increase in price ($397 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($67 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santo Domingo to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Santo Domingo to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 9/22

3:59 pm-11:17 pm

1 stop10h 18m

San Francisco

Wed 9/23

11:10 pm-1:19 pm

1 stop11h 09m

$599

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Thu 10/29

1:28 pm-11:30 pm

1 stop13h 02m

San Francisco

Tue 11/10

8:51 pm-1:18 pm

1 stop12h 27m

$599

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 9/5

4:44 pm-11:51 pm

1 stop10h 07m

San Francisco

Sat 9/12

10:10 pm-3:25 pm

1 stop14h 15m

$602

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 10/26

1:28 pm-11:30 pm

1 stop13h 02m

San Francisco

Thu 12/10

8:00 am-12:51 am

1 stop12h 51m

$673

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Fri 9/4

4:44 pm-11:51 pm

1 stop10h 07m

San Francisco

Fri 9/11

11:55 pm-11:50 am

2 stops32h 55m

$701

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 10/26

5:45 pm-11:40 pm

2 stops32h 55m

San Francisco

Thu 12/10

8:00 am-12:51 am

1 stop12h 51m

$722

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Sat 9/12

3:59 pm-9:05 am

1 stop20h 06m

San Francisco

Sat 9/19

10:28 am-2:49 pm

1 stop25h 21m

$753

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 9/1

4:44 pm-11:51 pm

1 stop10h 07m

San Francisco

Tue 9/8

10:40 pm-2:49 pm

1 stop13h 09m

$774
Cheapest one-way

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Mon 10/5

10:19 am-6:20 pm

2 stops35h 01m

$304

Santo DomingoSan Francisco

SDQ - SFO

SDQSFO

Santo Domingo Las Americas

Tue 10/6

3:35 pm-6:20 pm

2 stops29h 45m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/22

Showing 1-10 of 17 resultsSorted by cheapest first
1
2
  • Most accurate provider: When it comes to deals on Santo Domingo-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santo Domingo-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santo Domingo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to San Francisco

What is the cheapest month to book a flight from Santo Domingo to San Francisco?

Currently, March is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $526). Flying from Santo Domingo to San Francisco in July is currently the most expensive (average of $1,487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 23, 2026.
Peruse reviews from past customers who have flown with JetBlue from Santo Domingo to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
JetBlue
7.1
Good
3,019 reviews

Entertainment

7.2

Food

6.6

Comfort

7.5

Overall

7.1

Crew

7.9

Boarding

7.3

Reviews

1 / 20
4.0
Okay

Anonymous,Feb 2025

BOS - SFO

Flight was delayed an hour due to a flight plan issue. Then additional fuel was needed. The crew did communicate well. Upon departure there was not food available for purchase, at least not by the time they got to row 23. Wifi didn't work consistently. Not the normal Jetblue experience. The Captain and crew were great though.
JetBlue
7.1
Good
3,019 reviews
JetBlue
7.1
Good
3,019 reviews

Entertainment

7.2

Food

6.6

Comfort

7.5

Overall

7.1

Crew

7.9

Boarding

7.3

Reviews

1 / 20
4.0
Okay

Anonymous,Feb 2025

BOS - SFO

Flight was delayed an hour due to a flight plan issue. Then additional fuel was needed. The crew did communicate well. Upon departure there was not food available for purchase, at least not by the time they got to row 23. Wifi didn't work consistently. Not the normal Jetblue experience. The Captain and crew were great though.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santo Domingo to San Francisco?

    A quick flight from Santo Domingo to San Francisco can take about 10h 18m. JetBlue provides one of the quickest options available for as low as $599. Santo Domingo and San Francisco are separated by a distance of 3424 mi.

  • What is the cheapest airline to fly from Santo Domingo to San Francisco round-trip?

    Our cheapest airline available from Santo Domingo to San Francisco is JetBlue. Our recent data shows that you can find tickets from as low as $458 on this airline. JetBlue is currently priced 39% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Santo Domingo to San Francisco one-way?

    For one-way options, check prices for JetBlue. According to our data, you can fly for as low as $246. Users have also found prices from $334 and $347 on Delta and Aeromexico, respectively.

  • Can I find deals for flights from Santo Domingo to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santo Domingo to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santo Domingo to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to San Francisco.

  • Can I find deals for business class flights from Santo Domingo to San Francisco?

    Yes. Cheapflights offers flight deals from Santo Domingo to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santo Domingo to San Francisco?

    Currently, March is the cheapest month in which you can book a flight from Santo Domingo to San Francisco (average of $526). Flying from Santo Domingo to San Francisco in July is currently the most expensive (average of $1,487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Clara
Santa Cruz
Fairfield
Roseville
Burlingame
Rancho Cordova
San Bruno
Cupertino
Emeryville
Newark
Watsonville
Hayward
Redwood City
San Carlos
San Ramon
Turlock
Vallejo
San Lorenzo
Davis

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Santo Domingo to San Francisco

Discover the top airline that operate flights from Santo Domingo to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$458Average$555FlexibilityNo cancel feeOn-time62%

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