What is the cheapest airline to fly from Greenville to Santiago de los Caballeros round-trip?

Our cheapest airline available from Greenville to Santiago de los Caballeros is American Airlines. Our recent data shows that you can find tickets from as low as $461 on this airline.

What is the cheapest day to fly from Greenville to Santiago de los Caballeros?

Travelers seeking maximum savings on their Greenville to Santiago de los Caballeros flight should consider departing on Thursday mornings when fares are most often at their lowest. Wednesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago de los Caballeros ranges from 3.0 - 11.6 inches per month. December is typically the wettest month, when rainfall can reach 11.6 in. July is typically the driest time to visit Santiago de los Caballeros when rainfall is around 3.0 in.

If weather is an important factor for your trip to Santiago de los Caballeros, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 73.4 F).

What is the cheapest day to fly round-trip from Greenville to Santiago de los Caballeros?

Flights from Greenville to Santiago de los Caballeros are found to be more expensive on Tuesday. This shouldn't discourage you from searching as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Santiago de los Caballeros.

What is the cheapest time of day to fly from GSP to STI?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Greenville to Santiago de los Caballeros as you normally would.

How can I find direct flights from Greenville to Santiago de los Caballeros?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago de los Caballeros.

Can I find deals for business class flights from Greenville to Santiago de los Caballeros?

Yes. Cheapflights offers flight deals from Greenville to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$214+ Flights from Greenville to Santiago de los Caballeros

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Cheap flight deals from Greenville to Santiago de los Caballeros

Round-trip from	$461 (American Airlines)
One-way from	$214 (Delta)

From Greenville to Santiago de los Caballeros

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One-way flight from Greenville to Santiago de los Caballeros

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Find flight deals from Greenville to Santiago de los Caballeros

Cheapest flights from Greenville to Santiago de los Caballeros
Explore the most affordable flight options available from Greenville to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Thu 8/216:05 pmGSP - STI

1 stop18h 26mAmerican Airlines

Thu 9/41:29 pmSTI - GSP

1 stop10h 27mAmerican Airlines

Deal found 7/29

$461

Thu 8/219:24 pmGSP - STI

3 stops35h 51mMultiple Airlines

Thu 9/412:10 pmSTI - GSP

2 stops8h 34mMultiple Airlines

Deal found 7/29

$533

Best flights from Greenville to Santiago de los Caballeros
Discover carefully curated flight deals from Greenville to Santiago de los Caballeros that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2025.

Thu 8/216:05 pmGSP - STI

1 stop18h 26mAmerican Airlines

Thu 9/41:29 pmSTI - GSP

1 stop10h 27mAmerican Airlines

Deal found 7/29

$461

Thu 8/219:24 pmGSP - STI

3 stops35h 51mMultiple Airlines

Thu 9/412:10 pmSTI - GSP

2 stops8h 34mMultiple Airlines

Deal found 7/29

$533

Last-minute flights from Greenville to Santiago de los Caballeros
Discover last-minute flight deals from Greenville to Santiago de los Caballeros. Data last updated July 30, 2025 and is based on user searches.

Thu 8/216:05 pmGSP - STI

1 stop18h 26mAmerican Airlines

Thu 9/41:29 pmSTI - GSP

1 stop10h 27mAmerican Airlines

Deal found 7/29

$461

Thu 8/219:24 pmGSP - STI

3 stops35h 51mMultiple Airlines

Thu 9/412:10 pmSTI - GSP

2 stops8h 34mMultiple Airlines

Deal found 7/29

$533

One-way flights from Greenville to Santiago de los Caballeros
Search for one-way flight options from Greenville to Santiago de los Caballeros. Find affordable one-way fares based on user searches. Data last updated July 30, 2025.

Wed 10/155:30 amGSP - STI

2 stops13h 36mDelta

Deal found 7/28

$214

Wed 10/156:00 amGSP - STI

1 stop6h 13mAmerican Airlines

Deal found 7/28

$218

Cheapflights Fare Finder

Use the filters below to find and compare flights from Greenville to Santiago de los Caballeros that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleSantiago de los Caballeros

GSP - STI

GSPSTI

Greenville

Thu 8/21

6:05 pm-12:31 pm

1 stop18h 26m

Santiago de los Caballeros

Thu 9/4

1:29 pm-11:56 pm

1 stop10h 27m

$461

GreenvilleSantiago de los Caballeros

GSP - STI

GSPSTI

Greenville

Thu 8/21

9:24 pm-9:15 am

3 stops35h 51m

Santiago de los Caballeros

Thu 9/4

12:10 pm-8:44 pm

2 stops8h 34m

$533

GreenvilleSantiago de los Caballeros

GSP - STI

GSPSTI

Greenville

Wed 10/15

5:30 am-7:06 pm

2 stops13h 36m

$214

GreenvilleSantiago de los Caballeros

GSP - STI

GSPSTI

Greenville

Wed 10/15

6:00 am-12:13 pm

1 stop6h 13m

$218

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Best time to book a flight from Greenville to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Greenville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santiago de los Caballeros

What is the cheapest month to book a flight from Greenville to Santiago de los Caballeros?

Currently, May is the cheapest month in which you can book a flight from Greenville to Santiago de los Caballeros (average of $347). Flying from Greenville to Santiago de los Caballeros in July is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santiago de los Caballeros

Get a feel of what it's like to fly with Delta and American Airlines from Greenville to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,980 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What is the cheapest airline to fly from Greenville to Santiago de los Caballeros round-trip?
Our cheapest airline available from Greenville to Santiago de los Caballeros is American Airlines. Our recent data shows that you can find tickets from as low as $461 on this airline.
Can I find deals for flights from Greenville to Santiago de los Caballeros that include hotel bookings?
Yes. In addition to deals on Greenville to Santiago de los Caballeros flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Greenville to Santiago de los Caballeros?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Santiago de los Caballeros.
Can I find deals for business class flights from Greenville to Santiago de los Caballeros?
Yes. Cheapflights offers flight deals from Greenville to Santiago de los Caballeros by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Greenville to Santiago de los Caballeros?
Currently, May is the cheapest month in which you can book a flight from Greenville to Santiago de los Caballeros (average of $347). Flying from Greenville to Santiago de los Caballeros in July is currently the most expensive (average of $603). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Greenville to Santiago de los Caballeros

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$550	Average$641	FlexibilityNo cancel fee	On-time71%

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$214+ Cheap flights from Greenville (GSP) to Santiago de los Caballeros (STI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Greenville to Santiago de los Caballeros with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Greenville to Santiago de los Caballeros

Round-trip from

One-way from

Find flight deals from Greenville to Santiago de los Caballeros

Cheapest flights from Greenville to Santiago de los CaballerosExplore the most affordable flight options available from Greenville to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Explore the most affordable flight options available from Greenville to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Greenville to Santiago de los Caballeros that are best for you.

Best time to book a flight from Greenville to Santiago de los Caballeros

Have a flexible travel schedule? Discover the best time to fly to Santiago de los Caballeros from Greenville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Santiago de los Caballeros

What is the cheapest month to book a flight from Greenville to Santiago de los Caballeros?

Reviews of airlines servicing Santiago de los Caballeros

Get a feel of what it's like to fly with Delta and American Airlines from Greenville to Santiago de los Caballeros by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Santiago de los Caballeros. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What is the cheapest airline to fly from Greenville to Santiago de los Caballeros round-trip?

Can I find deals for flights from Greenville to Santiago de los Caballeros that include hotel bookings?

How can I find direct flights from Greenville to Santiago de los Caballeros?

Can I find deals for business class flights from Greenville to Santiago de los Caballeros?

What is the cheapest month to book a flight from Greenville to Santiago de los Caballeros?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to Santiago de los Caballeros

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Greenville to Santiago de los Caballeros

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Greenville to Santiago de los Caballeros
Explore the most affordable flight options available from Greenville to Santiago de los Caballeros. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.