HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$337+ Cheap flights from Myrtle Beach (MYR) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SCL
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$734
(American Airlines)

One-way from

$337
(Kiwi.com)
From Myrtle Beach Intl to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Myrtle Beach Intl to Santiago Arturo Merino Benitez
Search Deals

Find flight deals from Myrtle Beach to Santiago

Cheapest flights from Myrtle Beach to Santiago
Explore the most affordable flight options available from Myrtle Beach to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2310:01 amMYR - SCL
2 stops20h 59mAmerican Airlines
Mon 10/2710:15 pmSCL - MYR
2 stops19h 45mAmerican Airlines
Deal found 9/15$734
This Trip.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:43 pmMYR - SCL
2 stops42h 08mMultiple Airlines
Sun 10/2612:20 amSCL - MYR
2 stops18h 24mMultiple Airlines
Deal found 9/15$736
This LATAM Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/232:35 pmMYR - SCL
1 stop15h 25mLATAM Airlines
Mon 10/2710:10 pmSCL - MYR
1 stop12h 41mLATAM Airlines
Deal found 9/15$1,074

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Santiago that are best for you.

Fly from

Myrtle Beach

Fly to

Santiago

Route

Depart

Return

Price

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Thu 10/23

5:59 pm-8:00 am

2 stops13h 01m

Santiago Arturo Merino Benitez

Mon 10/27

10:15 pm-4:03 pm

1 stop18h 48m

$734

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Thu 10/23

7:43 pm-2:51 pm

2 stops42h 08m

Santiago Arturo Merino Benitez

Sun 10/26

12:20 am-5:44 pm

2 stops18h 24m

$736

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Thu 10/23

10:36 am-7:00 am

1 stop19h 24m

Santiago Arturo Merino Benitez

Sun 10/26

12:20 am-11:59 pm

2 stops24h 39m

$1,074

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Wed 10/29

7:00 am-5:30 am

2 stops21h 30m

$338

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Fri 11/7

8:30 pm-5:30 am

2 stops31h 00m

$338

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Thu 11/6

8:30 pm-5:30 am

2 stops31h 00m

$339

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Tue 11/4

12:06 pm-10:15 pm

3 stops32h 09m

$343

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Sat 11/8

8:22 pm-10:15 pm

3 stops47h 53m

$353

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Wed 11/5

4:03 pm-10:15 pm

3 stops52h 12m

$353

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Mon 11/3

8:14 am-10:15 pm

3 stops36h 01m

$353

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Myrtle Beach to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Santiago?

    For as low as $734, American Airlines can have you in Santiago from Myrtle Beach in 13h 01m. Myrtle Beach and Santiago are separated by a distance of 4661 mi.

  • Can I find deals for flights from Myrtle Beach to Santiago that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Santiago.

  • Can I find deals for business class flights from Myrtle Beach to Santiago?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Myrtle Beach to Santiago (average of $752). Flying from Myrtle Beach to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Santiago flights
Charleston to Santiago flights
Savannah to Santiago flights
Greenville to Santiago flights
Charlotte to Easter Island flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.