$305+ Cheap flights from Knoxville (TYS) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Sep 23 — Sep 301
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to SantiagoExplore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 24, 2026.
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/249:00 am -
2 stops20h 55m
Fri 8/285:10 am -
2 stops38h 52m
Deal found 8/20![Multiple Airlines logo]()
$1,031
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:23 pm -
1 stop11h 42m
Wed 9/28:50 pm -
1 stop22h 20m
Deal found 8/23![American Airlines logo]()
$1,047
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:23 pm -
1 stop11h 42m
Mon 10/59:30 pm -
1 stop26h 29m
Deal found 8/20![American Airlines logo]()
$1,058
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:06 am -
1 stop24h 19m
Sun 8/308:50 pm -
2 stops19h 07m
Deal found 8/20![American Airlines logo]()
$1,062
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
2 stops16h 41m
Sun 11/2911:10 pm -
1 stop18h 08m
Deal found 8/19![Delta logo]()
$1,065
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:23 pm -
1 stop11h 42m
Sat 10/39:30 pm -
2 stops21h 06m
Deal found 8/20![American Airlines logo]()
$1,082
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:51 pm -
2 stops39h 04m
Wed 9/25:10 am -
2 stops30h 52m
Deal found 8/20![Multiple Airlines logo]()
$1,083
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:38 pm -
1 stop14h 37m
Mon 9/78:55 pm -
2 stops14h 49m
Deal found 8/20![Delta logo]()
$1,087
This LATAM Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:38 pm -
3 stops20h 47m
Sun 10/45:50 pm -
2 stops18h 28m
Deal found 8/20![LATAM Airlines logo]()
$1,092
This oojo deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:16 pm -
2 stops16h 39m
Wed 9/28:30 am -
3 stops35h 40m
Deal found 8/20![LATAM Airlines logo]()
$1,113
Best flights from Knoxville to SantiagoDiscover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 24, 2026.
Discover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 24, 2026.
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
2 stops16h 41m
Sun 11/2911:10 pm -
1 stop18h 08m
Deal found 8/19![Delta logo]()
$1,065
This LATAM Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:10 am -
2 stops22h 05m
Sun 11/298:13 am -
2 stops27h 37m
Deal found 8/19![LATAM Airlines logo]()
$1,065
This Delta deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:55 am -
2 stops21h 05m
Fri 10/98:45 am -
2 stops16h 14m
Deal found 8/23![Delta logo]()
$1,117
This LATAM Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:23 pm -
2 stops17h 37m
Fri 10/98:45 am -
2 stops16h 14m
Deal found 8/21![LATAM Airlines logo]()
$1,117
Last-minute flights from Knoxville to SantiagoDiscover last-minute flight deals from Knoxville to Santiago. Data last updated August 24, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santiago. Data last updated August 24, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/249:00 am -
2 stops20h 55m
Fri 8/285:10 am -
2 stops38h 52m
Deal found 8/20![Multiple Airlines logo]()
$1,031
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:23 pm -
1 stop11h 42m
Wed 9/28:50 pm -
1 stop22h 20m
Deal found 8/23![American Airlines logo]()
$1,047
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:23 pm -
1 stop11h 42m
Mon 10/59:30 pm -
1 stop26h 29m
Deal found 8/20![American Airlines logo]()
$1,058
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:23 pm -
1 stop11h 42m
Sat 10/39:30 pm -
2 stops21h 06m
Deal found 8/20![American Airlines logo]()
$1,082
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:51 pm -
2 stops39h 04m
Wed 9/25:10 am -
2 stops30h 52m
Deal found 8/20![Multiple Airlines logo]()
$1,083
This LATAM Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/244:38 pm -
3 stops20h 47m
Wed 9/27:55 pm -
2 stops15h 16m
Deal found 8/21![LATAM Airlines logo]()
$1,092
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:23 pm -
1 stop11h 42m
Sun 10/49:30 pm -
1 stop26h 29m
Deal found 8/20![American Airlines logo]()
$1,115
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:06 am -
1 stop24h 19m
Sun 8/308:50 pm -
2 stops19h 07m
Deal found 8/20![American Airlines logo]()
$1,062
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/314:38 pm -
1 stop14h 37m
Mon 9/78:55 pm -
2 stops14h 49m
Deal found 8/20![Delta logo]()
$1,087
One-way flights from Knoxville to SantiagoSearch for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated August 24, 2026.
Search for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated August 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/163:54 pm -
2 stops32h 54m
Deal found 8/20![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/148:30 am -
2 stops18h 25m
Deal found 8/19![Multiple Airlines logo]()
$457
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/93:52 pm -
3 stops37h 08m
Deal found 8/19![Multiple Airlines logo]()
$477
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/1511:55 am -
3 stops39h 40m
Deal found 8/19![Multiple Airlines logo]()
$511
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/118:30 am -
3 stops33h 28m
Deal found 8/19![Multiple Airlines logo]()
$521
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/127:00 am -
2 stops21h 38m
Deal found 8/19![Multiple Airlines logo]()
$523
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/101:55 pm -
3 stops39h 05m
Deal found 8/19![Multiple Airlines logo]()
$603
Find flight deals from Knoxville to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 24, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $1,065 (Delta) |
One-way from | $305 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 24, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/20
12:34 pm-7:15 am
2 stops16h 41m
Santiago Arturo Merino Benitez
Sun 11/29
11:10 pm-3:18 pm
1 stop18h 08m
$1,065
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/20
7:10 am-7:15 am
2 stops22h 05m
Santiago Arturo Merino Benitez
Sun 11/29
8:13 am-9:50 am
2 stops27h 37m
$1,065
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Wed 9/30
8:55 am-7:00 am
2 stops21h 05m
Santiago Arturo Merino Benitez
Fri 10/9
8:45 am-11:59 pm
2 stops16h 14m
$1,117
Quickest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Wed 9/30
12:23 pm-7:00 am
2 stops17h 37m
Santiago Arturo Merino Benitez
Fri 10/9
8:45 am-11:59 pm
2 stops16h 14m
$1,117
Cheapest one-way
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Mon 11/16
2:21 pm-2:48 am
3 stops34h 27m
$353
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Sun 2/14
8:30 am-7:58 pm
3 stops33h 28m
$499
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Sat 2/13
10:00 am-7:58 pm
3 stops31h 58m
$523
Quickest one-way
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Wed 2/10
5:20 pm-8:50 am
1 stop13h 30m
$691
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Tue 2/9
12:00 pm-8:50 am
1 stop18h 50m
$691
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Sun 2/14
7:20 pm-7:40 am
1 stop34h 20m
$724
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santiago in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
TYS-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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