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$524+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$714
(LATAM Airlines)

One-way from

$524
(United Airlines)
From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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One-way flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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Find flight deals from Knoxville to Santiago

Cheapest flights from Knoxville to Santiago
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This LATAM Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:08 pmTYS - SCL
1 stop11h 52mLATAM Airlines
Mon 9/299:40 pmSCL - TYS
1 stop14h 16mLATAM Airlines
Deal found 9/13$714
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:45 amTYS - SCL
2 stops16h 55mCopa Airlines
Sun 9/281:24 amSCL - TYS
2 stops20h 47mCopa Airlines
Deal found 9/14$1,608

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Knoxville

Fly to

Santiago

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 9/25

6:08 pm-7:00 am

1 stop11h 52m

Santiago Arturo Merino Benitez

Mon 9/29

9:40 pm-10:56 am

1 stop14h 16m

$714

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 9/25

5:45 am-11:40 pm

2 stops16h 55m

Santiago Arturo Merino Benitez

Sun 9/28

1:24 am-9:11 pm

2 stops20h 47m

$1,608

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 1/4

5:35 pm-8:50 am

2 stops37h 15m

$524

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 1/4

12:18 pm-7:45 am

1 stop17h 27m

$558

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 1/4

12:00 pm-2:30 pm

3 stops24h 30m

$558

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santiago

What is the cheapest time of day to fly from TYS to SCL?

Find hourly flight availability from Knoxville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

It’s optimal to fly from Knoxville to Santiago in the afternoon. By choosing this option you can save up to 27% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 15, 2025.
Get a feel of what it's like to fly with LATAM Airlines and American Airlines from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,847 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.4

Overall

7.5

Food

6.7

Boarding

7.6

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
LATAM Airlines
7.5
Good
1,847 reviews
LATAM Airlines
7.5
Good
1,847 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.4

Overall

7.5

Food

6.7

Boarding

7.6

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing
American Airlines
7.2
Good
10,000 reviews
LATAM Airlines
7.5
Good
1,847 reviews

Entertainment

7.0

Crew

8.0

Comfort

7.4

Overall

7.5

Food

6.7

Boarding

7.6

Reviews

1 / 20
4.0
Okay

Murilo,Jun 2025

SFO - LAX

I had mixed feelings regarding this flight. Called several times Latam and Delta regarding the purchase of checked baggage and price. I was told 80 dollars, could not buy it ahead of time,, they told me it was not Possible, that I had to buy at the airport. Check in my luggage the attendant says 80 dollars but I was charged 200 . No one could get me a solid answer why. Very disappointing

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santiago?

    For as low as $714, LATAM Airlines can have you in Santiago from Knoxville in 11h 52m. The distance between Knoxville and Santiago is about 4853 mi.

  • What are the cheapest airlines flying from Knoxville to Santiago round-trip?

    American Airlines, at $692, was found to be the cheapest airline from Knoxville to Santiago. An alternate airline flying to your destination would be LATAM Airlines.

  • What are the cheapest airlines to fly from Knoxville to Santiago one-way?

    One-way options have recently been found by users for as low as $524 on United Airlines. Other airlines that offer cheap prices include American Airlines from $558 and LATAM Airlines from $558 one-way.

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Santiago (average of $752). Flying from Knoxville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Knoxville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Santiago

Discover the top 2 airlines that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$692Average$931FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$778Average$1,520FlexibilityNo cancel feeOn-time81%

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