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$291+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Aug 8 — Aug 151
Sat 8/8
Sat 8/15
1 adult, Economy
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Find cheap flights from Knoxville to Santiago with Cheapflights

1. Tell us where you want to go

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Cheap flight deals from Knoxville to Santiago

Cheapest flights from Knoxville to Santiago
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 9, 2026.

This Trip.com deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:51 pm
TYS
-
SCL
2 stops23h 24m
Multiple Airlines
Sat 8/2912:30 am
SCL
-
TYS
2 stops42h 33m
Multiple Airlines
Deal found 7/8$558
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:40 pm
TYS
-
SCL
1 stop11h 25m
American Airlines
Sun 8/308:50 pm
SCL
-
TYS
2 stops21h 32m
American Airlines
Deal found 7/8$952
This American Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:07 pm
TYS
-
SCL
1 stop13h 53m
American Airlines
Sun 11/2210:15 pm
SCL
-
TYS
1 stop20h 22m
American Airlines
Deal found 7/8$977
This United Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:00 am
TYS
-
SCL
2 stops23h 50m
United Airlines
Sun 11/2210:45 pm
SCL
-
TYS
2 stops27h 11m
United Airlines
Deal found 7/5$982
This United Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/611:53 am
TYS
-
SCL
1 stop18h 57m
United Airlines
Sun 11/2210:45 pm
SCL
-
TYS
2 stops27h 11m
United Airlines
Deal found 7/8$1,012
This LATAM Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:41 pm
TYS
-
SCL
2 stops21h 04m
LATAM Airlines
Sun 8/3011:05 pm
SCL
-
TYS
2 stops21h 05m
LATAM Airlines
Deal found 7/8$1,037
This oojo deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:23 pm
TYS
-
SCL
2 stops17h 32m
LATAM Airlines
Fri 10/97:45 am
SCL
-
TYS
2 stops17h 14m
LATAM Airlines
Deal found 7/8$1,047
This Delta deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:38 pm
TYS
-
SCL
1 stop14h 37m
Delta
Sun 8/308:40 pm
SCL
-
TYS
1 stop16h 54m
Delta
Deal found 7/8$1,067
This oojo deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:16 pm
TYS
-
SCL
3 stops23h 09m
LATAM Airlines
Sun 8/308:30 am
SCL
-
TYS
3 stops26h 41m
LATAM Airlines
Deal found 7/8$1,076

Find flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 9, 2026.

Most accurate provider

Ovago
3 stars

Most trusted provider

Ovago
3 stars

Round-trip from

$558
(Trip.com)

One-way from

$291
(Kiwi.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flights.
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From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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One-way flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 9, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 8/21

10:08 am-7:05 am

2 stops20h 57m

Santiago Arturo Merino Benitez

Sun 8/30

8:50 pm-1:31 pm

2 stops16h 41m

$952

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 11/18

7:00 am-8:50 am

2 stops23h 50m

Santiago Arturo Merino Benitez

Sun 11/22

10:45 pm-11:56 pm

2 stops27h 11m

$982

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 11/6

11:53 am-8:50 am

1 stop18h 57m

Santiago Arturo Merino Benitez

Sun 11/22

10:45 pm-11:56 pm

2 stops27h 11m

$1,012

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/20

7:41 pm-7:15 am

1 stop11h 34m

Santiago Arturo Merino Benitez

Sun 8/30

11:05 pm-11:52 pm

2 stops24h 47m

$1,037
Quickest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 9/30

12:23 pm-6:55 am

2 stops17h 32m

Santiago Arturo Merino Benitez

Fri 10/9

7:45 am-11:59 pm

2 stops17h 14m

$1,047
Cheapest one-way

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 8/21

8:30 am-5:14 am

3 stops20h 44m

$373
Quickest one-way

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 8/21

7:40 pm-7:05 am

1 stop11h 25m

$628

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 8/20

4:38 pm-7:15 am

1 stop14h 37m

$633

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 8/21

4:38 pm-1:25 pm

3 stops20h 47m

$734

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 12/17

7:00 am-1:30 pm

3 stops28h 30m

$736

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/5

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santiago in July.
ProviderPrice AccuracyTrust Score*
OvagoPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santiago?

    For as low as $952, American Airlines can have you in Santiago from Knoxville in 20h 57m. The distance between Knoxville and Santiago is about 4853 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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