$796+ Cheap flights from Knoxville (TYS) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Oct 23 — Oct 301
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to SantiagoExplore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 23, 2026.
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/411:59 am -
1 stop18h 51m
Wed 11/1110:45 pm -
1 stop21h 09m
Deal found 9/20![United Airlines logo]()
$1,040
This LATAM Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
2 stops16h 56m
Sun 11/294:35 pm -
2 stops26h 47m
Deal found 9/20![LATAM Airlines logo]()
$1,065
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am -
1 stop25h 10m
Sun 10/2510:15 pm -
2 stops20h 20m
Deal found 9/20![American Airlines logo]()
$1,133
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:00 pm -
1 stop13h 40m
Sun 11/2911:10 pm -
1 stop14h 18m
Deal found 9/20![Delta logo]()
$1,151
This LATAM Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:23 pm -
2 stops17h 22m
Fri 10/96:40 am -
2 stops18h 19m
Deal found 9/18![LATAM Airlines logo]()
$1,187
Best flights from Knoxville to SantiagoDiscover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
Discover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 23, 2026.
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/43:45 pm -
1 stop15h 05m
Wed 11/1110:45 pm -
2 stops24h 09m
Deal found 9/20![United Airlines logo]()
$1,045
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/12:19 pm -
1 stop14h 21m
Wed 1/139:50 pm -
1 stop13h 22m
Deal found 9/20![Delta logo]()
$1,065
This LATAM Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:21 pm -
2 stops33h 39m
Sun 11/294:35 pm -
2 stops26h 47m
Deal found 9/19![LATAM Airlines logo]()
$1,070
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am -
1 stop25h 10m
Sun 10/2510:15 pm -
1 stop25h 44m
Deal found 9/20![American Airlines logo]()
$1,139
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/57:20 pm -
2 stops17h 40m
Sat 3/1311:10 pm -
1 stop12h 56m
Deal found 9/21![Delta logo]()
$1,085
This LATAM Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/57:07 am -
1 stop21h 33m
Sat 3/1311:10 pm -
1 stop16h 55m
Deal found 9/21![LATAM Airlines logo]()
$1,085
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:30 pm -
2 stops38h 20m
Thu 11/510:45 pm -
2 stops19h 07m
Deal found 9/21![United Airlines logo]()
$1,522
Last-minute flights from Knoxville to SantiagoDiscover last-minute flight deals from Knoxville to Santiago. Data last updated September 23, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santiago. Data last updated September 23, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:23 pm -
2 stops17h 22m
Fri 10/96:40 am -
2 stops18h 19m
Deal found 9/18![LATAM Airlines logo]()
$1,187
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:08 am -
2 stops19h 52m
Fri 10/99:30 pm -
1 stop16h 39m
Deal found 9/18![American Airlines logo]()
$1,241
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am -
1 stop25h 10m
Sun 10/2510:15 pm -
2 stops20h 20m
Deal found 9/20![American Airlines logo]()
$1,133
This LATAM Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/187:45 pm -
2 stops18h 00m
Sun 10/257:40 am -
2 stops17h 19m
Deal found 9/20![LATAM Airlines logo]()
$1,217
One-way flights from Knoxville to SantiagoSearch for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
Search for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated September 23, 2026.
This LATAM Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:32 pm -
2 stops16h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![LATAM Airlines logo]()
$796
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:25 pm -
1 stop12h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![American Airlines logo]()
$876
Find flight deals from Knoxville to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 23, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $1,040 (United Airlines) |
One-way from | $796 (LATAM Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
12:32 pm-7:30 am
2 stops16h 58m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$796
Quickest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
6:25 pm-9:00 am
1 stop12h 35m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$876
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Wed 11/4
3:45 pm-8:50 am
1 stop15h 05m
Santiago Arturo Merino Benitez
Wed 11/11
10:45 pm-8:54 pm
2 stops24h 09m
$1,045
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 1/1
2:19 pm-6:40 am
1 stop14h 21m
Santiago Arturo Merino Benitez
Wed 1/13
9:50 pm-9:12 am
1 stop13h 22m
$1,065
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/20
7:21 pm-7:00 am
2 stops33h 39m
Santiago Arturo Merino Benitez
Sun 11/29
4:35 pm-5:22 pm
2 stops26h 47m
$1,070
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 3/5
7:20 pm-3:00 pm
2 stops17h 40m
Santiago Arturo Merino Benitez
Sat 3/13
11:10 pm-10:06 am
1 stop12h 56m
$1,085
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 3/5
7:07 am-6:40 am
1 stop21h 33m
Santiago Arturo Merino Benitez
Sat 3/13
11:10 pm-2:05 pm
1 stop16h 55m
$1,085
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Sun 10/18
6:00 am-8:10 am
1 stop25h 10m
Santiago Arturo Merino Benitez
Sun 10/25
10:15 pm-10:59 pm
1 stop25h 44m
$1,139
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Sun 11/1
4:30 pm-8:50 am
2 stops38h 20m
Santiago Arturo Merino Benitez
Thu 11/5
10:45 pm-3:52 pm
2 stops19h 07m
$1,522
Sorted by cheapest first
Compare providers for flights from Knoxville to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santiago in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
TYS-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 23, 2026.
Get a feel of what it's like to fly with Delta from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Food
7.2
Entertainment
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Comfort
7.8
Food
7.2
Entertainment
7.8
Crew
8.5
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Santiago
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Complete your trip
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Knoxville and Santiago flights
Browse other Knoxville and Santiago flight options. Last updated on September 23, 2026.
Other flights from Knoxville
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Popular flight searches
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Other flights to Santiago
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Top airline flying from Knoxville to Santiago
Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$714 | Average$1,128 | FlexibilityNo cancel fee | On-timeN/A |