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$714+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
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Cheap flight deals from Knoxville to Santiago

Best flights from Knoxville to Santiago
Discover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.

This LATAM Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/194:03 pmTYS - SCL
2 stops27h 52mLATAM Airlines
Mon 2/236:30 pmSCL - TYS
2 stops18h 38mLATAM Airlines
Deal found 12/25$714
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/24:30 pmTYS - SCL
1 stop13h 25mAmerican Airlines
Sun 3/810:15 pmSCL - TYS
1 stop20h 16mAmerican Airlines
Deal found 12/26$754
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:05 amTYS - SCL
1 stop23h 45mUnited Airlines
Sun 3/89:45 pmSCL - TYS
1 stop21h 25mUnited Airlines
Deal found 12/26$754
This Travelocity deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/22:38 pmTYS - SCL
2 stops21h 27mLATAM Airlines
Sun 3/810:25 pmSCL - TYS
2 stops26h 26mLATAM Airlines
Deal found 12/26$744
This United Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/197:05 amTYS - SCL
1 stop23h 45mUnited Airlines
Mon 2/2310:45 pmSCL - TYS
1 stop23h 10mUnited Airlines
Deal found 12/25$764

Find flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$714
(Delta)
Provider with most accurate pricing for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flights.
Search Deals
From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Knoxville

Fly to

Santiago

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 2/19

4:03 pm-9:55 pm

2 stops27h 52m

Santiago Arturo Merino Benitez

Mon 2/23

6:30 pm-11:08 am

2 stops18h 38m

$714

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/2

2:38 pm-2:05 pm

2 stops21h 27m

Santiago Arturo Merino Benitez

Sun 3/8

10:25 pm-11:51 pm

2 stops26h 26m

$744

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/2

4:30 pm-7:55 am

1 stop13h 25m

Santiago Arturo Merino Benitez

Sun 3/8

10:15 pm-5:31 pm

1 stop20h 16m

$754

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 3/2

7:05 am-8:50 am

1 stop23h 45m

Santiago Arturo Merino Benitez

Sun 3/8

9:45 pm-6:10 pm

1 stop21h 25m

$754

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 2/19

7:05 am-8:50 am

1 stop23h 45m

Santiago Arturo Merino Benitez

Mon 2/23

10:45 pm-7:55 pm

1 stop23h 10m

$764

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/25

  • Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated December 28, 2025.
Get a feel of what it's like to fly with American Airlines from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,072 reviews

Entertainment

6.9

Food

6.5

Comfort

7.2

Crew

8.0

Boarding

7.5

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,072 reviews
American Airlines
7.2
Good
11,072 reviews

Entertainment

6.9

Food

6.5

Comfort

7.2

Crew

8.0

Boarding

7.5

Overall

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santiago?

    For as low as $714, LATAM Airlines can have you in Santiago from Knoxville in 27h 52m. The distance between Knoxville and Santiago is about 4853 mi.

  • What is the cheapest airline to fly from Knoxville to Santiago round-trip?

    American Airlines, at $678, was found to be the cheapest airline from Knoxville to Santiago..

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Knoxville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Knoxville to Santiago

Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$678Average$931FlexibilityNo cancel feeOn-time71%

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