HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$714+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Santiago

Best flights from Knoxville to Santiago
Discover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 4, 2025.

This LATAM Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/192:38 pmTYS - SCL
1 stop16h 02mLATAM Airlines
Mon 3/235:15 amSCL - TYS
2 stops19h 36mLATAM Airlines
Deal found 12/1$714
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:00 amTYS - SCL
3 stops23h 50mUnited Airlines
Mon 3/239:45 pmSCL - TYS
2 stops24h 02mUnited Airlines
Deal found 12/3$769
This Travelocity deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/612:00 pmTYS - SCL
2 stops17h 00mLATAM Airlines
Sat 3/146:52 pmSCL - TYS
3 stops53h 59mLATAM Airlines
Deal found 12/3$890

Find flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$714
(LATAM Airlines)
Provider with most accurate pricing for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flights.
Search Deals
From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Knoxville

Fly to

Santiago

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 3/19

2:38 pm-7:40 am

1 stop16h 02m

Santiago Arturo Merino Benitez

Mon 3/23

5:15 am-11:51 pm

2 stops19h 36m

$714

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 3/19

7:00 am-7:50 am

3 stops23h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-8:47 pm

2 stops24h 02m

$769

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 3/6

12:00 pm-7:00 am

2 stops17h 00m

Santiago Arturo Merino Benitez

Sat 3/14

6:52 pm-11:51 pm

3 stops53h 59m

$890

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/1

  • Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santiago

What is the cheapest time of day to fly from TYS to SCL?

Find hourly flight availability from Knoxville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

It’s optimal to fly from Knoxville to Santiago in the afternoon. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated December 4, 2025.
Get a feel of what it's like to fly with American Airlines from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,047 reviews

Crew

8.0

Overall

7.2

Comfort

7.2

Food

6.5

Entertainment

6.9

Boarding

7.5

Reviews

1 / 20
4.0
Okay

Cameron,Nov 2025

PDX - LHR

The plane was very old...had no WiFi available. The crew were not friendly nor helpful.
American Airlines
7.2
Good
11,047 reviews
American Airlines
7.2
Good
11,047 reviews

Crew

8.0

Overall

7.2

Comfort

7.2

Food

6.5

Entertainment

6.9

Boarding

7.5

Reviews

1 / 20
4.0
Okay

Cameron,Nov 2025

PDX - LHR

The plane was very old...had no WiFi available. The crew were not friendly nor helpful.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santiago?

    For as low as $714, LATAM Airlines can have you in Santiago from Knoxville in 16h 02m. The distance between Knoxville and Santiago is about 4853 mi.

  • What is the cheapest airline to fly from Knoxville to Santiago round-trip?

    American Airlines, at $678, was found to be the cheapest airline from Knoxville to Santiago..

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Santiago flights
Memphis to Santiago flights
Blountville to Santiago flights

Top airline flying from Knoxville to Santiago

Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$678Average$931FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.