$518+ Cheap flights from Knoxville (TYS) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Dec 2 — Dec 91
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santiago
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Cheapest flights from Knoxville to SantiagoExplore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
This Trip.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:33 pm -
2 stops33h 12m
Thu 1/72:10 am -
2 stops20h 26m
Deal found 11/1![Multiple Airlines logo]()
$1,268
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:59 am -
1 stop18h 51m
Sun 11/2910:45 pm -
1 stop21h 09m
Deal found 10/31![United Airlines logo]()
$1,383
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:21 pm -
3 stops24h 09m
Sun 11/295:55 pm -
2 stops19h 33m
Deal found 10/28![LATAM Airlines logo]()
$1,388
This LATAM Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/314:52 pm -
1 stop11h 48m
Thu 1/77:40 am -
2 stops18h 18m
Deal found 11/1![LATAM Airlines logo]()
$1,551
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:22 pm -
1 stop12h 03m
Sun 11/2910:30 pm -
1 stop23h 50m
Deal found 10/29![American Airlines logo]()
$1,569
Best flights from Knoxville to SantiagoDiscover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
Discover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/57:35 pm -
3 stops35h 15m
Fri 3/1210:45 pm -
2 stops24h 37m
Deal found 10/30![United Airlines logo]()
$1,200
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/65:00 pm -
2 stops20h 00m
Sat 3/1310:50 pm -
1 stop18h 27m
Deal found 11/1![Delta logo]()
$1,236
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/54:20 pm -
3 stops27h 10m
Fri 3/1212:30 am -
2 stops33h 42m
Deal found 11/1![LATAM Airlines logo]()
$1,306
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/57:35 pm -
2 stops35h 15m
Sun 3/149:45 pm -
2 stops37h 15m
Deal found 11/1![United Airlines logo]()
$1,200
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/56:25 am -
2 stops30h 35m
Sat 3/138:13 am -
2 stops25h 59m
Deal found 11/1![Delta logo]()
$1,236
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:21 pm -
3 stops24h 09m
Sun 11/295:55 pm -
2 stops19h 33m
Deal found 10/28![LATAM Airlines logo]()
$1,388
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:59 am -
1 stop18h 51m
Sun 11/2910:45 pm -
1 stop21h 09m
Deal found 10/31![United Airlines logo]()
$1,383
Last-minute flights from Knoxville to SantiagoDiscover last-minute flight deals from Knoxville to Santiago. Data last updated November 2, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santiago. Data last updated November 2, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:59 am -
1 stop18h 51m
Thu 11/1910:45 pm -
1 stop21h 09m
Deal found 10/29![United Airlines logo]()
$1,592
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2011:59 am -
1 stop18h 51m
Sun 11/2910:45 pm -
1 stop21h 09m
Deal found 10/31![United Airlines logo]()
$1,383
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:21 pm -
3 stops24h 09m
Sun 11/295:55 pm -
2 stops19h 33m
Deal found 10/28![LATAM Airlines logo]()
$1,388
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:22 pm -
1 stop12h 03m
Sun 11/2910:30 pm -
1 stop23h 50m
Deal found 10/29![American Airlines logo]()
$1,569
One-way flights from Knoxville to SantiagoSearch for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
Search for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/143:47 pm -
3 stops59h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$518
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1411:53 am -
1 stop18h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![United Airlines logo]()
$776
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1710:41 am -
2 stops18h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$846
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:47 pm -
1 stop12h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$926
This FlightHub deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:00 am -
2 stops35h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![LATAM Airlines logo]()
$984
Find flight deals from Knoxville to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 2, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $1,188 (American Airlines) |
One-way from | $518 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 1/14
3:47 pm-5:03 am
3 stops59h 16m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$518
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 1/14
11:53 am-8:50 am
1 stop18h 57m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$776
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
10:41 am-7:00 am
2 stops18h 19m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$846
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
12:32 pm-2:20 pm
3 stops23h 48m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$846
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
6:30 am-8:00 am
1 stop23h 30m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$990
Quickest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
12:32 pm-7:00 am
2 stops16h 28m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$1,023
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 3/5
7:35 pm-8:50 am
3 stops35h 15m
Santiago Arturo Merino Benitez
Fri 3/12
10:45 pm-9:22 pm
2 stops24h 37m
$1,200
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 3/5
7:35 pm-8:50 am
2 stops35h 15m
Santiago Arturo Merino Benitez
Sun 3/14
9:45 pm-10:00 am
2 stops37h 15m
$1,200
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Sat 3/6
5:00 pm-3:00 pm
2 stops20h 00m
Santiago Arturo Merino Benitez
Sat 3/13
10:50 pm-3:17 pm
1 stop18h 27m
$1,236
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 3/5
6:25 am-3:00 pm
2 stops30h 35m
Santiago Arturo Merino Benitez
Sat 3/13
8:13 am-8:12 am
2 stops25h 59m
$1,236
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santiago in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
TYS-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated November 2, 2026.
Get a feel of what it's like to fly with Delta from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.2
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Food
7.2
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Santiago flights
Browse other Knoxville and Santiago flight options. Last updated on November 2, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Popular flight searches
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Top airline flying from Knoxville to Santiago
Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$904 | Average$1,321 | FlexibilityNo cancel fee | On-timeN/A |