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$875+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Apr 24 — Mai 11
Fr 4/24
Fr 5/1
1 adult, Economy
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Cheap flight deals from Knoxville to Santiago

Cheapest flights from Knoxville to Santiago
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on März 25, 2026.

This KAYAK deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 11/194:00 pm
TYS
-
SCL
1 stop13h 40m
LATAM Airlines
So 11/2911:25 pm
SCL
-
TYS
2 stops26h 21m
LATAM Airlines
Deal found 3/23$875
This KAYAK deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 9/3012:00 pm
TYS
-
SCL
2 stops17h 00m
LATAM Airlines
Fr 10/911:05 pm
SCL
-
TYS
2 stops20h 08m
LATAM Airlines
Deal found 3/24$925
This Expedia deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 9/304:00 pm
TYS
-
SCL
1 stop15h 15m
LATAM Airlines
Fr 10/912:05 am
SCL
-
TYS
2 stops19h 08m
LATAM Airlines
Deal found 3/24$951
This Expedia deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 10/17:20 pm
TYS
-
SCL
3 stops25h 55m
LATAM Airlines
Fr 10/95:10 am
SCL
-
TYS
2 stops19h 36m
LATAM Airlines
Deal found 3/24$1,011
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 6/1211:55 am
TYS
-
SCL
1 stop19h 20m
Delta
Sa 6/2010:55 pm
SCL
-
TYS
2 stops19h 02m
Delta
Deal found 3/25$1,035
This Expedia deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 6/127:43 pm
TYS
-
SCL
3 stops39h 06m
LATAM Airlines
Sa 6/2011:00 pm
SCL
-
TYS
2 stops34h 38m
LATAM Airlines
Deal found 3/25$1,066
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 11/195:07 pm
TYS
-
SCL
1 stop13h 53m
American Airlines
So 11/2910:15 pm
SCL
-
TYS
1 stop20h 22m
American Airlines
Deal found 3/20$1,150
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 6/126:00 am
TYS
-
SCL
1 stop25h 05m
American Airlines
Sa 6/209:00 pm
SCL
-
TYS
1 stop26h 59m
American Airlines
Deal found 3/25$1,155

Find flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated März 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$1,408
(United Airlines)
Provider with most accurate pricing for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flights.
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From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated März 25, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fr 6/12

11:55 am-7:15 am

1 stop19h 20m

Santiago Arturo Merino Benitez

Sa 6/20

10:55 pm-5:57 pm

2 stops19h 02m

$1,035

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fr 6/12

7:43 pm-10:49 am

3 stops39h 06m

Santiago Arturo Merino Benitez

Sa 6/20

11:00 pm-9:38 am

2 stops34h 38m

$1,066

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sa 9/19

5:57 pm-8:19 pm

3 stops49h 22m

Santiago Arturo Merino Benitez

Di 9/22

1:06 am-9:30 pm

2 stops21h 24m

$1,408
Quickest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mo 4/13

4:38 pm-1:25 pm

3 stops20h 47m

Santiago Arturo Merino Benitez

Mi 4/15

7:15 am-11:54 pm

2 stops16h 39m

$6,080

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mo 4/13

5:54 pm-1:45 pm

2 stops19h 51m

Santiago Arturo Merino Benitez

Mi 4/15

8:40 pm-5:08 pm

1 stop20h 28m

$10,538

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Sorted by cheapest first

Compare providers for flights from Knoxville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santiago in March.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated März 25, 2026.
Get a feel of what it's like to fly with American Airlines from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,494 reviews

Crew

7.9

Overall

7.1

Boarding

7.5

Food

6.4

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,494 reviews
American Airlines
7.1
Good
11,494 reviews

Crew

7.9

Overall

7.1

Boarding

7.5

Food

6.4

Comfort

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santiago?

    For as low as $1,035, Delta can have you in Santiago from Knoxville in 19h 20m. The distance between Knoxville and Santiago is about 4853 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Knoxville to Santiago round-trip?

    American Airlines, at $678, was found to be the cheapest airline from Knoxville to Santiago..

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Knoxville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Santiago flights
Memphis to Santiago flights

Top airline flying from Knoxville to Santiago

Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated März 25, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$678Average$931FlexibilityNo cancel feeOn-time71%

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