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$362+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Cheap flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$714
(American Airlines)

One-way from

$362
(Kiwi.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flight deals.
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From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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One-way flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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Find flight deals from Knoxville to Santiago

Cheapest flights from Knoxville to Santiago
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Mytrip deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/177:33 pmTYS - SCL
3 stops32h 28mMultiple Airlines
Fri 10/243:30 pmSCL - TYS
2 stops23h 00mMultiple Airlines
Deal found 10/16$1,052
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:15 amTYS - SCL
1 stop24h 45mAmerican Airlines
Fri 10/249:55 pmSCL - TYS
2 stops19h 49mAmerican Airlines
Deal found 10/16$1,181
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/912:10 pmTYS - SCL
1 stop17h 35mAmerican Airlines
Mon 1/511:55 pmSCL - TYS
1 stop19h 11mAmerican Airlines
Deal found 10/14$1,212
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/81:52 pmTYS - SCL
2 stops16h 58mUnited Airlines
Tue 1/610:45 pmSCL - TYS
2 stops20h 08mUnited Airlines
Deal found 10/14$1,231

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Knoxville

Fly to

Santiago

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 1/22

5:36 pm-9:05 am

1 stop13h 29m

Santiago Arturo Merino Benitez

Tue 2/3

11:15 pm-3:46 pm

1 stop18h 31m

$714

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 1/22

12:00 pm-7:00 am

1 stop17h 00m

Santiago Arturo Merino Benitez

Mon 2/2

4:35 am-11:44 pm

2 stops21h 09m

$824

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 12/8

11:42 am-8:50 am

1 stop19h 08m

Santiago Arturo Merino Benitez

Tue 1/6

10:45 pm-4:53 pm

2 stops20h 08m

$1,231

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 12/9

1:52 pm-8:50 am

2 stops16h 58m

Santiago Arturo Merino Benitez

Tue 1/6

10:45 pm-2:49 pm

2 stops18h 04m

$1,231

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 12/10

7:05 am-8:50 am

1 stop23h 45m

Santiago Arturo Merino Benitez

Tue 1/6

10:45 pm-2:49 pm

2 stops18h 04m

$1,231

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 12/9

4:22 pm-7:45 am

1 stop13h 23m

Santiago Arturo Merino Benitez

Mon 1/5

11:55 pm-11:59 pm

1 stop26h 04m

$1,232

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 11/20

6:00 am-11:41 pm

2 stops39h 41m

$362

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 11/20

4:25 pm-8:50 am

1 stop14h 25m

$518

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

  • Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santiago

What is the cheapest time of day to fly from TYS to SCL?

Find hourly flight availability from Knoxville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

It’s optimal to fly from Knoxville to Santiago in the afternoon. By choosing this option you can save up to 26% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 16, 2025.
Get a feel of what it's like to fly with LATAM Airlines and American Airlines from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
LATAM Airlines
7.5
Good
1,866 reviews

Boarding

7.6

Entertainment

7.0

Crew

8.0

Food

6.7

Comfort

7.3

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP
LATAM Airlines
7.5
Good
1,866 reviews
LATAM Airlines
7.5
Good
1,866 reviews

Boarding

7.6

Entertainment

7.0

Crew

8.0

Food

6.7

Comfort

7.3

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP
American Airlines
7.2
Good
11,040 reviews
LATAM Airlines
7.5
Good
1,866 reviews

Boarding

7.6

Entertainment

7.0

Crew

8.0

Food

6.7

Comfort

7.3

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Oct 2025

MIA - GRU

Terrible baggage service! Almost lost my connection flight in SP

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santiago?

    For as low as $714, American Airlines can have you in Santiago from Knoxville in 13h 29m. The distance between Knoxville and Santiago is about 4853 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Santiago round-trip?

    American Airlines, at $678, was found to be the cheapest airline from Knoxville to Santiago. An alternate airline flying to your destination would be LATAM Airlines.

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Knoxville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Blountville to Santiago flights

Top 2 airlines flying from Knoxville to Santiago

Discover the top 2 airlines that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$678Average$931FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$778Average$1,520FlexibilityNo cancel feeOn-time81%

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