HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$524+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$754
(United Airlines)

One-way from

$524
(United Airlines)
From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
Search Deals

Find flight deals from Knoxville to Santiago

Cheapest flights from Knoxville to Santiago
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:23 pmTYS - SCL
2 stops35h 27mUnited Airlines
Wed 1/2810:45 pmSCL - TYS
2 stops16h 33mUnited Airlines
Deal found 8/13$810
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:32 pmTYS - SCL
1 stop13h 18mAmerican Airlines
Sun 12/1411:15 pmSCL - TYS
1 stop20h 06mAmerican Airlines
Deal found 8/13$814
This Orbitz deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:36 pmTYS - SCL
3 stops24h 59mLATAM Airlines
Wed 1/2810:35 amSCL - TYS
2 stops15h 09mLATAM Airlines
Deal found 8/13$828
This LATAM Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:00 pmTYS - SCL
3 stops21h 05mLATAM Airlines
Sun 12/146:30 pmSCL - TYS
2 stops16h 41mLATAM Airlines
Deal found 8/13$854
This deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:59 pmTYS - SCL
1 stop13h 51mUnited Airlines
Sun 12/1410:45 pmSCL - TYS
1 stop17h 04mUnited Airlines
Deal found 8/12$904
This LATAM Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/236:14 pmTYS - SCL
2 stops19h 51mLATAM Airlines
Tue 8/268:40 pmSCL - TYS
1 stop14h 02mLATAM Airlines
Deal found 8/11$1,014
This Copa Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/235:45 amTYS - SCL
2 stops17h 23mCopa Airlines
Mon 8/2512:13 amSCL - TYS
2 stops20h 43mCopa Airlines
Deal found 8/13$1,172

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Knoxville

Fly to

Santiago

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 2/9

5:20 pm-8:50 am

1 stop13h 30m

Santiago Arturo Merino Benitez

Thu 2/26

10:45 pm-7:34 pm

1 stop22h 49m

$754

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 2/9

4:00 pm-2:05 pm

2 stops20h 05m

Santiago Arturo Merino Benitez

Wed 2/25

4:35 am-11:44 pm

2 stops21h 09m

$794

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 12/28

7:23 pm-8:50 am

2 stops35h 27m

Santiago Arturo Merino Benitez

Wed 1/28

10:45 pm-1:18 pm

2 stops16h 33m

$810

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 12/5

4:32 pm-7:50 am

1 stop13h 18m

Santiago Arturo Merino Benitez

Sun 12/14

11:15 pm-5:21 pm

1 stop20h 06m

$814

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 12/28

6:36 pm-9:35 pm

3 stops24h 59m

Santiago Arturo Merino Benitez

Wed 1/28

10:35 am-11:44 pm

2 stops15h 09m

$828

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 1/4

5:33 pm-8:50 am

2 stops37h 17m

$524

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 1/4

4:25 pm-7:50 am

1 stop13h 25m

$558

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Sun 1/4

2:32 pm-2:30 pm

3 stops21h 58m

$578

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santiago

What is the cheapest time of day to fly from TYS to SCL?

Find hourly flight availability from Knoxville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

It’s optimal to fly from Knoxville to Santiago in the afternoon. By choosing this option you can save up to 27% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated August 14, 2025.
Get a feel of what it's like to fly with American Airlines from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Crew

8.0

Food

6.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Crew

8.0

Food

6.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What is the cheapest airline to fly from Knoxville to Santiago round-trip?

    American Airlines, at $692, was found to be the cheapest airline from Knoxville to Santiago..

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Santiago (average of $752). Flying from Knoxville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Santiago flights
Memphis to Santiago flights
Blountville to Santiago flights

Top airline flying from Knoxville to Santiago

Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$692Average$931FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.