$396+ Cheap flights from Knoxville (TYS) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Nov 19 — Nov 261
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santiago
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Cheapest flights from Knoxville to SantiagoExplore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:00 pm -
1 stop13h 50m
Wed 12/910:45 pm -
1 stop21h 33m
Deal found 10/18![United Airlines logo]()
$1,167
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:22 pm -
1 stop12h 03m
Mon 12/711:15 pm -
1 stop16h 47m
Deal found 10/16![American Airlines logo]()
$1,177
This KAYAK deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1611:53 am -
2 stops15h 59m
Thu 1/712:20 pm -
2 stops23h 50m
Deal found 10/19![Copa Airlines logo]()
$1,194
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:35 pm -
2 stops35h 15m
Mon 12/710:45 pm -
3 stops23h 52m
Deal found 10/16![United Airlines logo]()
$1,195
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:00 am -
1 stop23h 50m
Wed 11/1810:45 pm -
1 stop21h 09m
Deal found 10/18![United Airlines logo]()
$1,218
This BusinessClass deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:35 am -
2 stops19h 35m
Fri 10/3010:15 pm -
1 stop15h 54m
Deal found 10/15![GOL logo]()
$1,244
This LATAM Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/212:32 pm -
3 stops24h 28m
Wed 12/98:25 pm -
2 stops15h 36m
Deal found 10/18![LATAM Airlines logo]()
$1,252
This BusinessClass deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:41 pm -
2 stops15h 29m
Tue 10/2710:15 pm -
1 stop25h 44m
Deal found 10/15![GOL logo]()
$1,256
Best flights from Knoxville to SantiagoDiscover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
Discover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/25:00 pm -
1 stop13h 50m
Wed 12/910:45 pm -
1 stop21h 33m
Deal found 10/18![United Airlines logo]()
$1,167
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:22 pm -
1 stop12h 03m
Mon 12/711:15 pm -
1 stop16h 47m
Deal found 10/16![American Airlines logo]()
$1,177
This LATAM Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:21 pm -
2 stops20h 19m
Sun 11/294:35 pm -
2 stops33h 22m
Deal found 10/17![LATAM Airlines logo]()
$1,383
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:35 pm -
2 stops35h 15m
Mon 12/710:45 pm -
3 stops23h 52m
Deal found 10/16![United Airlines logo]()
$1,195
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:22 pm -
1 stop12h 03m
Sun 11/2910:30 pm -
2 stops18h 51m
Deal found 10/20![American Airlines logo]()
$1,441
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
1 stop23h 50m
Sun 11/2910:45 pm -
2 stops37h 29m
Deal found 10/19![United Airlines logo]()
$1,364
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:59 am -
1 stop18h 51m
Thu 11/1910:45 pm -
1 stop21h 09m
Deal found 10/19![United Airlines logo]()
$1,592
Last-minute flights from Knoxville to SantiagoDiscover last-minute flight deals from Knoxville to Santiago. Data last updated October 20, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santiago. Data last updated October 20, 2026 and is based on user searches.
This BusinessClass deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:35 am -
2 stops19h 35m
Fri 10/3010:15 pm -
1 stop15h 54m
Deal found 10/15![GOL logo]()
$1,244
This BusinessClass deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:41 pm -
2 stops15h 29m
Tue 10/2710:15 pm -
1 stop25h 44m
Deal found 10/15![GOL logo]()
$1,256
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:00 am -
1 stop23h 50m
Wed 11/1810:45 pm -
1 stop21h 09m
Deal found 10/18![United Airlines logo]()
$1,218
This Expedia deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:00 pm -
3 stops27h 40m
Wed 11/188:35 am -
3 stops28h 53m
Deal found 10/18![LATAM Airlines logo]()
$1,313
This LATAM Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:00 pm -
2 stops27h 50m
Sun 11/294:35 pm -
2 stops26h 47m
Deal found 10/19![LATAM Airlines logo]()
$1,278
This United Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
1 stop23h 50m
Sun 11/2910:45 pm -
2 stops37h 29m
Deal found 10/17![United Airlines logo]()
$1,303
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:22 pm -
1 stop12h 03m
Mon 12/711:15 pm -
1 stop16h 47m
Deal found 10/16![American Airlines logo]()
$1,177
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/307:35 pm -
2 stops35h 15m
Mon 12/710:45 pm -
3 stops23h 52m
Deal found 10/16![United Airlines logo]()
$1,195
One-way flights from Knoxville to SantiagoSearch for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
Search for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/26:20 am -
2 stops22h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/18:00 am -
2 stops20h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$413
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/17:00 am -
1 stop23h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![American Airlines logo]()
$776
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/27:00 am -
1 stop23h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![American Airlines logo]()
$824
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1710:41 am -
2 stops18h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Delta logo]()
$841
This LATAM Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/177:26 pm -
3 stops24h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![LATAM Airlines logo]()
$889
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1711:43 am -
1 stop19h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![United Airlines logo]()
$891
Find flight deals from Knoxville to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $1,167 (United Airlines) |
One-way from | $396 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 1/1
8:00 am-6:38 am
2 stops20h 38m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$413
Quickest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
6:17 pm-7:40 am
1 stop11h 23m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$841
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
10:41 am-7:00 am
2 stops18h 19m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$841
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
11:43 am-8:50 am
1 stop19h 07m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$891
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Wed 12/2
5:00 pm-8:50 am
1 stop13h 50m
Santiago Arturo Merino Benitez
Wed 12/9
10:45 pm-6:18 pm
1 stop21h 33m
$1,167
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Mon 11/30
7:22 pm-9:25 am
1 stop12h 03m
Santiago Arturo Merino Benitez
Mon 12/7
11:15 pm-2:02 pm
1 stop16h 47m
$1,177
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Mon 11/30
7:35 pm-8:50 am
2 stops35h 15m
Santiago Arturo Merino Benitez
Mon 12/7
10:45 pm-8:37 pm
3 stops23h 52m
$1,195
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/20
7:00 am-8:50 am
1 stop23h 50m
Santiago Arturo Merino Benitez
Sun 11/29
10:45 pm-10:14 am
2 stops37h 29m
$1,364
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/20
7:21 pm-5:40 pm
2 stops20h 19m
Santiago Arturo Merino Benitez
Sun 11/29
4:35 pm-11:57 pm
2 stops33h 22m
$1,383
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/20
7:22 pm-9:25 am
1 stop12h 03m
Santiago Arturo Merino Benitez
Sun 11/29
10:30 pm-3:21 pm
2 stops18h 51m
$1,441
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santiago in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
TYS-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated October 20, 2026.
Get a feel of what it's like to fly with Delta from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Comfort
7.8
Overall
7.8
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Santiago flights
Browse other Knoxville and Santiago flight options. Last updated on October 20, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on October 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 20, 2026.
Top airline flying from Knoxville to Santiago
Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$874 | Average$1,321 | FlexibilityNo cancel fee | On-timeN/A |