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$288+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Jul 16 — Jul 231
Thu 7/16
Thu 7/23
1 adult, Economy
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Cheap flight deals from Knoxville to Santiago

Cheapest flights from Knoxville to Santiago
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.

This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2712:00 pm
TYS
-
SCL
1 stop18h 50m
United Airlines
Tue 11/1010:45 pm
SCL
-
TYS
1 stop16h 35m
United Airlines
Deal found 6/13$945
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:15 am
TYS
-
SCL
1 stop25h 35m
American Airlines
Sun 10/49:30 pm
SCL
-
TYS
2 stops19h 22m
American Airlines
Deal found 6/13$954
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:13 am
TYS
-
SCL
1 stop24h 47m
American Airlines
Sat 11/710:15 pm
SCL
-
TYS
1 stop27h 30m
American Airlines
Deal found 6/13$980
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:15 am
TYS
-
SCL
1 stop21h 35m
United Airlines
Sat 11/710:45 pm
SCL
-
TYS
2 stops26h 52m
United Airlines
Deal found 6/13$981
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:39 pm
TYS
-
SCL
2 stops19h 11m
American Airlines
Sat 10/109:30 pm
SCL
-
TYS
2 stops16h 26m
American Airlines
Deal found 6/13$1,027
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:43 pm
TYS
-
SCL
2 stops17h 07m
American Airlines
Fri 10/99:30 pm
SCL
-
TYS
2 stops16h 26m
American Airlines
Deal found 6/12$1,033
This oojo deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:30 pm
TYS
-
SCL
2 stops20h 35m
LATAM Airlines
Fri 10/94:10 am
SCL
-
TYS
2 stops20h 36m
LATAM Airlines
Deal found 6/15$1,064

Find flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 16, 2026.

Most accurate provider

Ovago
3 stars

Most trusted provider

Ovago
3 stars

Round-trip from

$945
(United Airlines)

One-way from

$288
(Kiwi.com)
Provider with most accurate pricing for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flights.
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From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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One-way flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 9/25

4:46 pm-8:50 am

2 stops15h 04m

Santiago Arturo Merino Benitez

Sun 10/4

9:30 pm-3:52 pm

2 stops19h 22m

$954

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 10/29

9:15 am-7:50 am

1 stop21h 35m

Santiago Arturo Merino Benitez

Sat 11/7

10:45 pm-11:37 pm

2 stops26h 52m

$981
Quickest round-trip

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 10/29

4:02 pm-9:00 am

2 stops15h 58m

Santiago Arturo Merino Benitez

Sat 11/7

10:15 pm-2:19 pm

2 stops18h 04m

$984

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Thu 10/1

6:15 am-8:50 am

1 stop25h 35m

Santiago Arturo Merino Benitez

Sat 10/10

9:30 pm-12:56 pm

2 stops16h 26m

$1,037

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 9/30

7:00 am-8:50 am

1 stop24h 50m

Santiago Arturo Merino Benitez

Fri 10/9

9:30 pm-12:56 pm

2 stops16h 26m

$1,043

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 9/30

10:26 am-8:15 am

1 stop20h 49m

Santiago Arturo Merino Benitez

Fri 10/9

7:15 am-11:46 pm

2 stops17h 31m

$1,067

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Wed 9/30

12:00 pm-5:25 pm

2 stops28h 25m

Santiago Arturo Merino Benitez

Fri 10/9

7:45 am-11:46 pm

2 stops17h 01m

$1,067
Cheapest one-way
Quickest one-way

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 10/19

7:00 am-3:16 am

2 stops19h 16m

$288

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 9/25

8:20 am-6:10 am

2 stops20h 50m

$368

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 9/25

6:15 am-8:50 am

1 stop25h 35m

$649

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Sorted by cheapest first

Compare providers for flights from Knoxville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santiago in June.
ProviderPrice AccuracyTrust Score*
OvagoPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 16, 2026.
Get a feel of what it's like to fly with Delta from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,404 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.9
Good
8,404 reviews
Delta
7.9
Good
8,404 reviews

Food

7.2

Boarding

8.1

Comfort

7.8

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santiago?

    For as low as $954, American Airlines can have you in Santiago from Knoxville in 15h 04m. The distance between Knoxville and Santiago is about 4853 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Knoxville to Santiago round-trip?

    Delta, at $714, was found to be the cheapest airline from Knoxville to Santiago..

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Knoxville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Santiago flights
Memphis to Santiago flights

Top airline flying from Knoxville to Santiago

Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$714Average$1,395FlexibilityNo cancel feeOn-timeN/A

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