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$772+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Sep 11 — Sep 181
Fri 9/11
Fri 9/18
1 adult, Economy
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Cheap flight deals from Knoxville to Santiago

Cheapest flights from Knoxville to Santiago
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 12, 2026.

This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/265:15 pm -
1 stop13h 35m
Thu 11/510:45 pm -
1 stop14h 27m
Deal found 8/10$945
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:45 am -
2 stops21h 05m
Mon 11/210:45 pm -
2 stops24h 09m
Deal found 8/10$950
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:35 pm -
2 stops35h 15m
Mon 11/210:45 pm -
1 stop14h 27m
Deal found 8/10$969
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2511:59 am -
1 stop18h 51m
Thu 11/510:45 pm -
1 stop14h 27m
Deal found 8/10$985
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:51 pm -
2 stops16h 59m
Fri 11/610:45 pm -
1 stop14h 27m
Deal found 8/10$990
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:59 am -
1 stop18h 51m
Mon 11/210:45 pm -
1 stop21h 09m
Deal found 8/10$997
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:35 pm -
2 stops35h 15m
Sat 11/710:45 pm -
2 stops20h 04m
Deal found 8/10$1,009
This Expedia deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:09 pm -
1 stop11h 31m
Fri 12/189:50 pm -
1 stop13h 22m
Deal found 8/10$1,024
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2511:59 am -
1 stop18h 51m
Fri 11/610:45 pm -
1 stop14h 27m
Deal found 8/10$1,025

Find flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 12, 2026.

Most accurate provider

Ovago
3 stars

Most trusted provider

Ovago
3 stars

Round-trip from

$945
(United Airlines)

One-way from

$772
(oojo)
Provider with most accurate pricing for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santiago Arturo Merino Benitez flights.
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From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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One-way flight from Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Thu 1/21

8:30 am-8:50 am

3 stops22h 20m

Santiago Arturo Merino Benitez

Wed 2/3

10:45 pm-10:00 am

2 stops37h 15m

$976
Quickest round-trip

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Sun 10/25

11:59 am-7:50 am

1 stop18h 51m

Santiago Arturo Merino Benitez

Mon 11/2

10:45 pm-11:12 am

1 stop14h 27m

$985

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Mon 10/26

1:51 pm-7:50 am

2 stops16h 59m

Santiago Arturo Merino Benitez

Sun 11/8

10:45 pm-4:51 pm

2 stops20h 06m

$990

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Tue 10/27

5:15 pm-7:50 am

1 stop13h 35m

Santiago Arturo Merino Benitez

Sun 11/8

10:45 pm-4:51 pm

2 stops20h 06m

$990

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Wed 9/30

4:40 pm-3:00 pm

2 stops21h 20m

Santiago Arturo Merino Benitez

Fri 10/9

8:40 pm-1:31 pm

1 stop17h 51m

$1,035

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Fri 11/20

7:21 pm-5:40 pm

2 stops20h 19m

Santiago Arturo Merino Benitez

Sun 11/29

4:05 pm-11:57 pm

2 stops33h 52m

$1,035

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Sat 10/31

7:00 am-7:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

Sat 11/7

10:45 pm-9:57 pm

1 stop25h 12m

$1,062
Cheapest one-way

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Thu 12/17

7:21 pm-9:30 pm

3 stops24h 09m

$809
Quickest one-way

KnoxvilleSantiago

TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez

TYSSCL

Knoxville McGhee Tyson

Thu 12/17

12:18 pm-7:45 am

1 stop17h 27m

$985

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/11

Sorted by cheapest first

Compare providers for flights from Knoxville to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santiago in August.
ProviderPrice AccuracyTrust Score*
OvagoPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santiago?

    For as low as $945, United Airlines can have you in Santiago from Knoxville in 13h 35m. The distance between Knoxville and Santiago is about 4853 mi.

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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