$270+ Cheap flights from Chicago (CHI) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/22. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — SCL
Jun 28 — Jul 51
Round-trip
1 adult, Economy
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Find cheap flights from Chicago to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to Santiago
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Cheapest flights from Chicago to SantiagoExplore the most affordable flight options available from Chicago to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.
Explore the most affordable flight options available from Chicago to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:13 pm
ORD
- SCL
2 stops32h 47m
Multiple Airlines
Wed 8/2610:55 pm
SCL
- ORD
1 stop19h 11m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$621
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:44 pm
ORD
- SCL
2 stops32h 13m
Multiple Airlines
Tue 11/31:02 am
SCL
- ORD
1 stop14h 44m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$622
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:05 am
ORD
- SCL
2 stops19h 51m
Multiple Airlines
Sat 10/2412:23 pm
SCL
- ORD
1 stop14h 34m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$623
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:44 pm
ORD
- SCL
2 stops32h 33m
Multiple Airlines
Sat 11/711:55 pm
SCL
- ORD
1 stop20h 39m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$628
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:05 am
ORD
- SCL
2 stops19h 51m
Multiple Airlines
Tue 10/2712:28 pm
SCL
- ORD
1 stop14h 37m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$635
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:13 pm
ORD
- SCL
2 stops32h 47m
Multiple Airlines
Mon 8/242:56 am
SCL
- ORD
1 stop23h 06m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$637
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:05 am
ORD
- SCL
2 stops19h 51m
Multiple Airlines
Thu 10/221:44 am
SCL
- ORD
1 stop14h 15m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$643
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:26 am
ORD
- SCL
2 stops15h 51m
Multiple Airlines
Thu 11/1211:55 pm
SCL
- ORD
1 stop20h 39m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$644
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:05 am
ORD
- SCL
2 stops19h 51m
Multiple Airlines
Mon 10/2611:10 pm
SCL
- ORD
1 stop14h 56m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$648
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:13 pm
ORD
- SCL
2 stops32h 47m
Multiple Airlines
Thu 8/278:40 pm
SCL
- ORD
1 stop16h 56m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$651
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:44 pm
ORD
- SCL
2 stops25h 49m
Multiple Airlines
Wed 11/1111:55 pm
SCL
- ORD
1 stop20h 39m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$653
This deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:25 pm
MDW
- SCL
1 stop12h 50m
Delta
Sun 10/2511:10 pm
SCL
- MDW
1 stop14h 46m
Delta
Deal found 5/28![Delta logo]()
$735
Best flights from Chicago to SantiagoDiscover carefully curated flight deals from Chicago to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 29, 2026.
Discover carefully curated flight deals from Chicago to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 29, 2026.
This Copa Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:02 am
ORD
- SCL
1 stop14h 24m
Copa Airlines
Sat 8/82:14 am
SCL
- ORD
1 stop23h 48m
Copa Airlines
Deal found 5/24![Copa Airlines logo]()
$683
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:30 pm
MDW
- SCL
1 stop13h 45m
Delta
Tue 9/158:40 pm
SCL
- MDW
1 stop17h 15m
Delta
Deal found 5/28![Delta logo]()
$735
This LATAM Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1810:05 am
ORD
- SCL
3 stops34h 40m
LATAM Airlines
Thu 6/258:40 pm
SCL
- ORD
1 stop14h 33m
LATAM Airlines
Deal found 5/28![LATAM Airlines logo]()
$740
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:35 am
MDW
- SCL
2 stops16h 25m
Delta
Sun 11/1512:20 pm
SCL
- MDW
2 stops24h 32m
Delta
Deal found 5/28![Delta logo]()
$735
This Copa Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/18:02 am
ORD
- SCL
1 stop14h 24m
Copa Airlines
Sat 8/82:14 am
SCL
- ORD
1 stop23h 48m
Copa Airlines
Deal found 5/24![Copa Airlines logo]()
$751
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/257:00 am
ORD
- SCL
1 stop23h 15m
Delta
Sun 8/28:40 pm
SCL
- ORD
1 stop14h 33m
Delta
Deal found 5/24![Delta logo]()
$735
This Copa Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/62:13 pm
ORD
- SCL
1 stop31h 06m
Copa Airlines
Mon 11/165:07 am
SCL
- ORD
1 stop22h 04m
Copa Airlines
Deal found 5/28![Copa Airlines logo]()
$771
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2711:23 am
ORD
- SCL
1 stop18h 52m
Delta
Sat 7/47:55 pm
SCL
- ORD
2 stops19h 34m
Delta
Deal found 5/28![Delta logo]()
$735
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:10 pm
MDW
- SCL
1 stop13h 05m
Delta
Sat 8/2211:00 pm
SCL
- MDW
2 stops20h 33m
Delta
Deal found 5/24![Delta logo]()
$740
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/98:02 am
ORD
- SCL
1 stop22h 13m
Delta
Sun 8/1611:00 pm
SCL
- ORD
2 stops20h 28m
Delta
Deal found 5/24![Delta logo]()
$740
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/257:00 am
ORD
- SCL
1 stop23h 15m
Delta
Wed 7/2911:00 pm
SCL
- ORD
2 stops19h 12m
Delta
Deal found 5/24![Delta logo]()
$740
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/812:41 pm
MDW
- SCL
1 stop17h 34m
Delta
Wed 7/158:40 pm
SCL
- MDW
1 stop20h 35m
Delta
Deal found 5/24![Delta logo]()
$783
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:05 pm
MDW
- SCL
1 stop15h 35m
Delta
Fri 11/2011:10 pm
SCL
- MDW
1 stop20h 15m
Delta
Deal found 5/28![Delta logo]()
$783
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/169:30 am
ORD
- SCL
2 stops18h 30m
Delta
Sat 10/2410:55 pm
SCL
- ORD
1 stop20h 39m
Delta
Deal found 5/28![Delta logo]()
$783
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/1612:46 pm
MDW
- SCL
2 stops15h 49m
Delta
Wed 8/268:40 pm
SCL
- MDW
1 stop14h 19m
Delta
Deal found 5/27![Delta logo]()
$822
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:10 pm
MDW
- SCL
1 stop13h 05m
Delta
Mon 8/318:40 pm
SCL
- MDW
1 stop19h 58m
Delta
Deal found 5/27![Delta logo]()
$822
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/165:10 pm
MDW
- SCL
1 stop13h 05m
Delta
Thu 8/278:40 pm
SCL
- MDW
1 stop14h 19m
Delta
Deal found 5/27![Delta logo]()
$822
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:00 pm
ORD
- SCL
1 stop16h 25m
Delta
Thu 8/278:40 pm
SCL
- ORD
1 stop17h 00m
Delta
Deal found 5/27![Delta logo]()
$822
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:10 pm
MDW
- SCL
1 stop13h 05m
Delta
Sat 9/198:40 pm
SCL
- MDW
1 stop15h 13m
Delta
Deal found 5/26![Delta logo]()
$831
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:25 pm
MDW
- SCL
2 stops17h 40m
Delta
Sat 11/1411:10 pm
SCL
- MDW
1 stop20h 15m
Delta
Deal found 5/28![Delta logo]()
$831
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:25 pm
MDW
- SCL
2 stops17h 40m
Delta
Mon 11/1611:10 pm
SCL
- MDW
1 stop13h 42m
Delta
Deal found 5/27![Delta logo]()
$831
Last-minute flights from Chicago to SantiagoDiscover last-minute flight deals from Chicago to Santiago. Data last updated May 29, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to Santiago. Data last updated May 29, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:59 pm
ORD
- SCL
2 stops33h 01m
Multiple Airlines
Mon 6/2911:05 pm
SCL
- ORD
1 stop19h 06m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$700
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:59 pm
ORD
- SCL
2 stops33h 01m
Multiple Airlines
Tue 6/238:40 pm
SCL
- ORD
1 stop16h 56m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$706
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:59 pm
ORD
- SCL
2 stops33h 01m
Multiple Airlines
Wed 6/248:40 pm
SCL
- ORD
1 stop14h 33m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$708
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:59 pm
ORD
- SCL
2 stops33h 01m
Multiple Airlines
Thu 6/258:40 pm
SCL
- ORD
1 stop23h 02m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$710
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/174:59 pm
ORD
- SCL
2 stops33h 01m
Multiple Airlines
Mon 6/2911:05 pm
SCL
- ORD
1 stop19h 06m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$687
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/174:59 pm
ORD
- SCL
2 stops33h 01m
Multiple Airlines
Sat 6/278:40 pm
SCL
- ORD
1 stop23h 02m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$717
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/174:59 pm
ORD
- SCL
2 stops33h 01m
Multiple Airlines
Tue 6/238:40 pm
SCL
- ORD
1 stop16h 56m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$725
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:59 pm
ORD
- SCL
2 stops49h 24m
Multiple Airlines
Mon 6/2911:05 pm
SCL
- ORD
1 stop19h 06m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$656
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:59 pm
ORD
- SCL
2 stops49h 24m
Multiple Airlines
Sat 6/278:40 pm
SCL
- ORD
1 stop23h 02m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$686
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:59 pm
ORD
- SCL
2 stops28h 44m
Multiple Airlines
Thu 6/258:40 pm
SCL
- ORD
1 stop24h 52m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$711
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:59 pm
ORD
- SCL
2 stops33h 01m
Multiple Airlines
Mon 6/2911:05 pm
SCL
- ORD
1 stop19h 06m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$701
This LATAM Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/2511:23 am
ORD
- SCL
1 stop18h 52m
LATAM Airlines
Mon 7/610:55 pm
SCL
- ORD
1 stop19h 11m
LATAM Airlines
Deal found 5/28![LATAM Airlines logo]()
$727
One-way flights from Chicago to SantiagoSearch for one-way flight options from Chicago to Santiago. Find affordable one-way fares based on user searches. Data last updated May 29, 2026.
Search for one-way flight options from Chicago to Santiago. Find affordable one-way fares based on user searches. Data last updated May 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/224:49 pm
ORD
- SCL
2 stops49h 43m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/289:26 am
ORD
- SCL
2 stops36h 13m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/249:26 am
ORD
- SCL
2 stops40h 30m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/128:20 pm
MDW
- SCL
3 stops46h 03m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:29 pm
ORD
- SCL
3 stops36h 31m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:49 pm
ORD
- SCL
2 stops52h 50m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$356
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/11:12 pm
MDW
- SCL
3 stops34h 35m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:00 am
ORD
- SCL
3 stops39h 32m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:03 pm
ORD
- SCL
3 stops35h 32m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$366
This Kiwi.com deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:55 am
ORD
- SCL
3 stops35h 28m
Multiple Airlines
Deal found 5/28![Multiple Airlines logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/274:49 pm
ORD
- SCL
2 stops29h 33m
Multiple Airlines
Deal found 5/24![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:03 pm
ORD
- SCL
3 stops38h 07m
Multiple Airlines
Deal found 5/29![Multiple Airlines logo]()
$378
Find flight deals from Chicago to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Chicago (CHI) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $621 (Kiwi.com) |
One-way from | $270 (Kiwi.com) |
Popular in | December |
Cheapest in | March |
Average price | $789 |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
Use the filters below to find and compare flights from Chicago to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Wed 8/5
8:02 am-11:26 pm
1 stop14h 24m
Santiago Arturo Merino Benitez
Sat 8/8
2:14 am-1:02 am
1 stop23h 48m
$683
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
Tue 9/8
4:30 pm-8:15 am
1 stop13h 45m
Santiago Arturo Merino Benitez
Tue 9/15
8:40 pm-11:55 am
1 stop17h 15m
$735
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
Fri 11/13
10:35 am-6:00 am
2 stops16h 25m
Santiago Arturo Merino Benitez
Sun 11/15
12:20 pm-9:52 am
2 stops24h 32m
$735
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sat 7/25
7:00 am-7:15 am
1 stop23h 15m
Santiago Arturo Merino Benitez
Sun 8/2
8:40 pm-10:13 am
1 stop14h 33m
$735
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sat 6/27
11:23 am-7:15 am
1 stop18h 52m
Santiago Arturo Merino Benitez
Sat 7/4
7:55 pm-2:29 pm
2 stops19h 34m
$735
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Thu 6/18
10:05 am-9:45 pm
3 stops34h 40m
Santiago Arturo Merino Benitez
Thu 6/25
8:40 pm-10:13 am
1 stop14h 33m
$740
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
Fri 8/14
5:10 pm-7:15 am
1 stop13h 05m
Santiago Arturo Merino Benitez
Sat 8/22
11:00 pm-6:33 pm
2 stops20h 33m
$740
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sun 8/9
8:02 am-7:15 am
1 stop22h 13m
Santiago Arturo Merino Benitez
Sun 8/16
11:00 pm-6:28 pm
2 stops20h 28m
$740
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sat 7/25
7:00 am-7:15 am
1 stop23h 15m
Santiago Arturo Merino Benitez
Wed 7/29
11:00 pm-5:12 pm
2 stops19h 12m
$740
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Sat 8/1
8:02 am-11:26 pm
1 stop14h 24m
Santiago Arturo Merino Benitez
Sat 8/8
2:14 am-1:02 am
1 stop23h 48m
$751
Showing 1-10 of 38 resultsSorted by cheapest first
Compare providers for flights from Chicago to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Chicago to Santiago in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Chicago-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Chicago to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Chicago with our price prediction graph.
CHI-SCL
ORD-SCL
MDW-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to Santiago
CHI-SCL
ORD-SCL
MDW-SCL
What is the cheapest month to book a flight from Chicago to Santiago?
Currently, March is the cheapest month in which you can book a flight from Chicago to Santiago (average of $302). Flying from Chicago to Santiago in November is currently the most expensive (average of $626). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Chicago to Santiago?
What’s the top layover airport for flights from Chicago to Santiago?
Share of 1-stop round-trip flights from Chicago to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Panama City (PTY) – chosen by Cheapflights users on 71% of 1-stop itineraries from Chicago to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from Chicago to Santiago?
Average round-trip fare for 1-stop flights from Chicago to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Bogotá (BOG) is the most affordable 1-stop option, with an average round-trip price of $558.
What’s the fastest layover option from Chicago to Santiago?
Shortest average travel time for 1-stop one-way flights from Chicago to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Panama City (PTY) have the shortest average one-way travel time for 1-stop routes: 12h 38m.
Which airport typically offers the quickest layover for flights from Chicago to Santiago?
Average layover duration for 1-stop one-way flights from Chicago to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Panama City (PTY) offer the fastest connection on this route, with an average layover time of 1h 24m.
How often are flights from Chicago to Santiago delayed?
About 0% of weekly flights between Chicago and Santiago have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Chicago to Santiago flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Wednesday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
How far ahead should I book a flight from Chicago to Santiago?
The price you pay for your flight from Chicago to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 88 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated May 29, 2026.
Read through reviews of airlines operating flights from Chicago to Santiago, such as Delta,LATAM Airlines, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Food
7.2
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Chicago to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Chicago to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Chicago to Santiago by cabin class
Find flights from Chicago to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Chicago and Santiago flights
Browse other Chicago and Santiago flight options. Last updated on May 29, 2026.
Other flights from Chicago
Browse through other flights departing from Chicago. Flights are based on user searches made on Cheapflights and were last updated on May 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 29, 2026.
Top 6 airlines flying from Chicago to Santiago
Discover the top 6 airlines that operate flights from Chicago to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$537 | Average$679 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$540 | Average$750 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$567 | Average$790 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$568 | Average$844 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$597 | Average$906 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$626 | Average$796 | FlexibilityNo cancel fee | On-time69% |