How long is the flight from Chicago to Santiago?

Avianca, Delta, and LATAM Airlines can get you from Chicago to Santiago in just under 12h 36m. Your travel time can differ by up to 2h 14m. Airlines will cover a distance of 5301 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Chicago to Santiago round-trip?

According to our current data, Copa Airlines ($511), Avianca ($558), and Delta ($698) offers the cheapest pricing from Chicago to Santiago. Copa Airlines is 40% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest day to fly from Chicago to Santiago?

Travelers seeking maximum savings on their Chicago to Santiago flight should consider departing on Monday at noon when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

What are the most popular airlines that fly from Chicago to Santiago?

When booking a flight from Chicago to Santiago, you may want to consider flying on American Airlines, Air Canada or Avianca as they are the most popular for this route.

What airport do you fly into for flights to Santiago from Chicago?

For a flight from Chicago to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city. Arturo Merino Benitez is the only Santiago airport and it handles 0 inbound flights from Chicago per day. 7 airlines have flights to Santiago Arturo Merino Benitez from Chicago on a regular basis.

Can I find deals for flights from Chicago to Santiago that include hotel bookings?

Yes. In addition to deals on Chicago to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Chicago to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to Santiago.

Can I find deals for business class flights from Chicago to Santiago?

Yes. Cheapflights offers flight deals from Chicago to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$268+ Cheap Flights from Chicago to Santiago

Q: How much does it cost to fly round-trip from Chicago to Santiago?

Airfare is below average for this route at the moment. Chicago to Santiago flights typically cost between $614 and $1,008 in November. The cheapest round-trip price found within the last 3 days was $604 on Multiple Airlines (Nov 10-Nov 16).

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Cheapflights Tip: The best prices from Chicago to Santiago Arturo Merino Benitez are usually found in April or August, booked 22 days in advance, depart on a Monday or Wednesday and return on a Monday

Cheap flight deals from Chicago to Santiago

Round-trip from	$604 (Mytrip)
One-way from	$268 (Mytrip)
Popular in	December
Cheapest in	April
Average price	$799

From Chicago (CHI) to Santiago Arturo Merino Benitez

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One-way flight from Chicago (CHI) to Santiago Arturo Merino Benitez

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($124 potential increase over avg. RT price).

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Cheapest flight prices on average. 3% potential price decrease ($33 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

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Find flight deals from Chicago to Santiago

Cheapest flights from Chicago to Santiago
Explore the most affordable flight options available from Chicago to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Mon 11/107:30 pmORD - SCL

3 stops29h 05mMultiple Airlines

Sun 11/1612:30 pmSCL - ORD

2 stops27h 00mMultiple Airlines

Deal found 9/14

$604

Sat 10/259:27 amORD - SCL

2 stops42h 23mMultiple Airlines

Fri 10/3110:50 amSCL - ORD

1 stop23h 28mMultiple Airlines

Deal found 9/15

$607

Fri 10/3110:27 amORD - SCL

3 stops23h 48mMultiple Airlines

Fri 11/79:05 pmSCL - ORD

3 stops29h 00mMultiple Airlines

Deal found 9/16

$610

Thu 10/3010:27 amORD - SCL

2 stops33h 48mMultiple Airlines

Thu 11/611:25 pmSCL - ORD

1 stop16h 05mMultiple Airlines

Deal found 9/15

$611

Mon 11/101:35 pmORD - SCL

2 stops35h 00mMultiple Airlines

Wed 11/1911:25 pmSCL - ORD

1 stop16h 05mMultiple Airlines

Deal found 9/14

$618

Wed 10/1511:13 amORD - SCL

3 stops33h 02mMultiple Airlines

Wed 10/297:25 amSCL - ORD

2 stops27h 57mMultiple Airlines

Deal found 9/16

$619

Tue 9/162:35 pmORD - SCL

1 stop21h 50mAvianca

Tue 9/303:30 pmSCL - ORD

1 stop23h 45mAvianca

Deal found 9/15

$620

Sun 11/91:35 pmORD - SCL

2 stops29h 40mMultiple Airlines

Sun 11/1610:50 amSCL - ORD

1 stop28h 40mMultiple Airlines

Deal found 9/14

$621

Tue 11/410:20 pmORD - SCL

1 stop14h 00mMultiple Airlines

Tue 11/184:25 pmSCL - ORD

2 stops48h 13mMultiple Airlines

Deal found 9/14

$623

Sun 11/91:35 pmORD - SCL

2 stops29h 40mMultiple Airlines

Tue 11/1811:25 pmSCL - ORD

1 stop16h 05mMultiple Airlines

Deal found 9/14

$633

Mon 10/2010:27 amORD - SCL

3 stops23h 53mMultiple Airlines

Wed 10/293:35 amSCL - ORD

3 stops23h 28mMultiple Airlines

Deal found 9/15

$634

Sun 9/286:30 pmMDW - SCL

2 stops21h 45mLATAM Airlines

Wed 10/19:40 pmSCL - MDW

1 stop16h 08mLATAM Airlines

Deal found 9/15

$739

Best flights from Chicago to Santiago
Discover carefully curated flight deals from Chicago to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2025.

Tue 11/44:03 pmORD - SCL

3 stops34h 47mMultiple Airlines

Tue 11/1812:30 pmSCL - ORD

3 stops33h 46mMultiple Airlines

Deal found 9/14

$648

Tue 11/410:20 pmORD - SCL

1 stop14h 00mAvianca

Sun 11/91:35 amSCL - ORD

1 stop21h 45mAvianca

Deal found 9/14

$663

Tue 11/46:56 amORD - SCL

1 stop13h 45mCopa Airlines

Mon 11/173:23 amSCL - ORD

1 stop23h 42mCopa Airlines

Deal found 9/14

$672

Mon 2/212:50 pmORD - SCL

2 stops20h 25mAir Canada

Tue 2/178:55 pmSCL - ORD

2 stops21h 00mAir Canada

Deal found 9/15

$697

Tue 11/410:40 amMDW - SCL

2 stops14h 50mDelta

Tue 11/188:20 amSCL - MDW

2 stops18h 12mDelta

Deal found 9/14

$764

Wed 10/295:04 pmMDW - SCL

1 stop12h 36mLATAM Airlines

Wed 11/511:10 pmSCL - MDW

1 stop13h 35mLATAM Airlines

Deal found 9/14

$764

Fri 10/3110:27 amORD - SCL

3 stops23h 48mMultiple Airlines

Thu 11/61:35 amSCL - ORD

3 stops24h 30mMultiple Airlines

Deal found 9/16

$667

Thu 11/1310:20 pmORD - SCL

1 stop14h 00mAvianca

Sun 11/161:35 amSCL - ORD

1 stop21h 45mAvianca

Deal found 9/15

$669

Mon 10/137:59 amORD - SCL

1 stop14h 05mCopa Airlines

Mon 10/204:47 amSCL - ORD

1 stop21h 34mCopa Airlines

Deal found 9/15

$672

Sun 9/2810:27 amORD - SCL

3 stops23h 53mMultiple Airlines

Wed 10/111:00 amSCL - ORD

1 stop24h 18mMultiple Airlines

Deal found 9/15

$668

Tue 11/46:56 amORD - SCL

1 stop17h 47mCopa Airlines

Mon 11/105:12 amSCL - ORD

1 stop21h 53mCopa Airlines

Deal found 9/15

$672

Thu 10/3010:40 amMDW - SCL

2 stops17h 55mDelta

Thu 11/611:10 pmSCL - MDW

1 stop20h 04mDelta

Deal found 9/15

$764

Mon 9/2912:43 pmMDW - SCL

1 stop16h 17mLATAM Airlines

Mon 10/69:40 pmSCL - MDW

1 stop14h 00mLATAM Airlines

Deal found 9/13

$764

Fri 11/76:56 amORD - SCL

1 stop17h 28mCopa Airlines

Sat 11/223:23 amSCL - ORD

1 stop23h 42mCopa Airlines

Deal found 9/14

$692

Tue 11/410:40 amMDW - SCL

1 stop18h 00mDelta

Mon 11/1011:10 pmSCL - MDW

1 stop20h 28mDelta

Deal found 9/14

$764

Fri 10/33:07 pmORD - SCL

1 stop12h 53mCopa Airlines

Sun 10/1212:29 pmSCL - ORD

1 stop13h 52mCopa Airlines

Deal found 9/15

$692

Mon 1/1210:35 amMDW - SCL

1 stop16h 35mDelta

Mon 1/266:30 pmSCL - MDW

2 stops18h 26mDelta

Deal found 9/15

$764

Tue 1/2710:35 amMDW - SCL

1 stop17h 25mDelta

Tue 2/1011:15 pmSCL - MDW

1 stop13h 41mDelta

Deal found 9/14

$764

Mon 2/21:05 pmMDW - SCL

1 stop14h 55mDelta

Tue 2/176:30 pmSCL - MDW

2 stops18h 26mDelta

Deal found 9/14

$764

Last-minute flights from Chicago to Santiago
Discover last-minute flight deals from Chicago to Santiago. Data last updated September 16, 2025 and is based on user searches.

Tue 9/162:35 pmORD - SCL

1 stop21h 50mAvianca

Tue 9/303:30 pmSCL - ORD

1 stop23h 45mAvianca

Deal found 9/15

$620

Sun 9/286:30 pmMDW - SCL

2 stops21h 45mLATAM Airlines

Wed 10/19:40 pmSCL - MDW

1 stop16h 08mLATAM Airlines

Deal found 9/15

$739

Mon 9/296:30 pmMDW - SCL

2 stops16h 50mLATAM Airlines

Mon 10/65:55 pmSCL - MDW

2 stops17h 45mLATAM Airlines

Deal found 9/13

$764

Mon 10/1310:35 amMDW - SCL

2 stops17h 10mDelta

Mon 10/2010:55 pmSCL - MDW

2 stops19h 14mDelta

Deal found 9/13

$768

Tue 10/1411:13 amORD - SCL

3 stops33h 02mMultiple Airlines

Wed 10/227:10 amSCL - ORD

2 stops28h 12mMultiple Airlines

Deal found 9/16

$637

Tue 10/1412:48 pmMDW - SCL

2 stops16h 02mLATAM Airlines

Tue 10/2110:55 pmSCL - MDW

2 stops14h 58mLATAM Airlines

Deal found 9/16

$752

Wed 10/1511:13 amORD - SCL

3 stops33h 02mMultiple Airlines

Wed 10/297:25 amSCL - ORD

2 stops27h 57mMultiple Airlines

Deal found 9/16

$619

Mon 10/2010:27 amORD - SCL

2 stops33h 48mMultiple Airlines

Wed 10/293:35 amSCL - ORD

3 stops23h 28mMultiple Airlines

Deal found 9/15

$634

Sat 10/259:27 amORD - SCL

2 stops42h 23mMultiple Airlines

Fri 10/3110:50 amSCL - ORD

1 stop23h 28mMultiple Airlines

Deal found 9/15

$607

Wed 10/2911:20 pmORD - SCL

1 stop14h 00mMultiple Airlines

Wed 11/59:05 pmSCL - ORD

2 stops18h 25mMultiple Airlines

Deal found 9/14

$642

Thu 10/3010:27 amORD - SCL

2 stops33h 48mMultiple Airlines

Thu 11/611:25 pmSCL - ORD

1 stop16h 05mMultiple Airlines

Deal found 9/15

$611

Fri 10/3110:27 amORD - SCL

2 stops33h 48mMultiple Airlines

Fri 11/79:05 pmSCL - ORD

3 stops25h 11mMultiple Airlines

Deal found 9/16

$610

One-way flights from Chicago to Santiago
Search for one-way flight options from Chicago to Santiago. Find affordable one-way fares based on user searches. Data last updated September 16, 2025.

Mon 10/610:27 amORD - SCL

3 stops23h 53mMultiple Airlines

Deal found 9/14

$268

Sun 10/1910:27 amORD - SCL

3 stops23h 53mMultiple Airlines

Deal found 9/15

$273

Mon 2/21:35 pmORD - SCL

2 stops29h 40mMultiple Airlines

Deal found 9/14

$275

Mon 10/2712:17 pmMDW - SCL

2 stops31h 58mMultiple Airlines

Deal found 9/16

$278

Fri 10/310:27 amORD - SCL

3 stops23h 53mMultiple Airlines

Deal found 9/14

$289

Thu 10/211:13 amORD - SCL

3 stops40h 47mMultiple Airlines

Deal found 9/14

$291

Fri 11/142:21 pmORD - SCL

3 stops28h 54mMultiple Airlines

Deal found 9/14

$293

Wed 10/1511:13 amORD - SCL

3 stops33h 02mMultiple Airlines

Deal found 9/15

$296

Thu 10/21:49 pmMDW - SCL

3 stops30h 26mMultiple Airlines

Deal found 9/14

$302

Tue 11/1112:37 pmORD - SCL

3 stops30h 38mMultiple Airlines

Deal found 9/14

$302

Fri 10/39:47 pmMDW - SCL

3 stops47h 43mMultiple Airlines

Deal found 9/14

$372

Sun 10/199:26 pmMDW - SCL

3 stops39h 19mMultiple Airlines

Deal found 9/15

$374

Fly from

Fly to

Route

Depart

Return

Price

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Tue 11/4

4:03 pm-5:50 am

3 stops34h 47m

Santiago Arturo Merino Benitez

Tue 11/18

12:30 pm-7:16 pm

3 stops33h 46m

$648

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Tue 11/4

10:20 pm-3:20 pm

1 stop14h 00m

Santiago Arturo Merino Benitez

Sun 11/9

1:35 am-8:20 pm

1 stop21h 45m

$663

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Fri 10/31

10:27 am-12:15 pm

3 stops23h 48m

Santiago Arturo Merino Benitez

Thu 11/6

1:35 am-11:05 pm

3 stops24h 30m

$667

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Sun 9/28

10:27 am-12:20 pm

3 stops23h 53m

Santiago Arturo Merino Benitez

Wed 10/1

11:00 am-9:18 am

1 stop24h 18m

$668

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Thu 11/13

10:20 pm-3:20 pm

1 stop14h 00m

Santiago Arturo Merino Benitez

Sun 11/16

1:35 am-8:20 pm

1 stop21h 45m

$669

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Tue 11/4

6:56 am-11:41 pm

1 stop13h 45m

Santiago Arturo Merino Benitez

Mon 11/17

3:23 am-12:05 am

1 stop23h 42m

$672

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Mon 10/13

7:59 am-12:04 am

1 stop14h 05m

Santiago Arturo Merino Benitez

Mon 10/20

4:47 am-12:21 am

1 stop21h 34m

$672

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Tue 11/4

6:56 am-3:43 am

1 stop17h 47m

Santiago Arturo Merino Benitez

Mon 11/10

5:12 am-12:05 am

1 stop21h 53m

$672

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Fri 11/7

6:56 am-3:24 am

1 stop17h 28m

Santiago Arturo Merino Benitez

Sat 11/22

3:23 am-12:05 am

1 stop23h 42m

$692

ChicagoSantiago

ORD - SCL

ORDSCL

Chicago O'Hare Intl

Fri 10/3

3:07 pm-6:00 am

1 stop12h 53m

Santiago Arturo Merino Benitez

Sun 10/12

12:29 pm-12:21 am

1 stop13h 52m

$692

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 38 results

Best time to book a flight from Chicago to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Chicago with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Chicago to Santiago

How far ahead should I book a flight from Chicago to Santiago?

The price you pay for your flight from Chicago to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 22 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Chicago to Santiago?

Currently, April is the cheapest month in which you can book a flight from Chicago to Santiago (average of $752). Flying from Chicago to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHI to SCL?

When flying from Chicago to Santiago, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 11% versus a flight in the afternoon.

How much does it cost to fly round-trip from Chicago to Santiago?

Reviews of airlines servicing Santiago

Read through reviews of airlines operating flights from Chicago to Santiago, such as Delta, Copa Airlines, and LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,957 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.6

Good

1,531 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,847 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Avianca

6.7

Okay

2,435 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What airport do you fly into for flights to Santiago from Chicago?
For a flight from Chicago to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city. Arturo Merino Benitez is the only Santiago airport and it handles 0 inbound flights from Chicago per day. 7 airlines have flights to Santiago Arturo Merino Benitez from Chicago on a regular basis.
How long is the flight from Chicago to Santiago?
Avianca, Delta, and LATAM Airlines can get you from Chicago to Santiago in just under 12h 36m. Your travel time can differ by up to 2h 14m. Airlines will cover a distance of 5301 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Chicago to Santiago round-trip?
According to our current data, Copa Airlines ($511), Avianca ($558), and Delta ($698) offers the cheapest pricing from Chicago to Santiago. Copa Airlines is 40% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Chicago to Santiago that include hotel bookings?
Yes. In addition to deals on Chicago to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Chicago to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Chicago to Santiago.
Can I find deals for business class flights from Chicago to Santiago?
Yes. Cheapflights offers flight deals from Chicago to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Chicago to Santiago?
Currently, April is the cheapest month in which you can book a flight from Chicago to Santiago (average of $752). Flying from Chicago to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Other flights to Santiago

Top 7 airlines flying from Chicago to Santiago

Airline	Cheapest	Average	Flexibility	On-time
Copa Airlines	Cheapest$511	Average$861	FlexibilityNo cancel fee	On-time70%
Avianca	Cheapest$558	Average$724	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$698	Average$920	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$703	Average$1,021	FlexibilityNo cancel fee	On-time81%
American Airlines	Cheapest$703	Average$951	FlexibilityNo cancel fee	On-time71%
Air Canada	Cheapest$707	Average$951	FlexibilityNo cancel fee	On-time67%
United Airlines	Cheapest$823	Average$953	FlexibilityNo cancel fee	On-time69%

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$268+ Cheap flights from Chicago (CHI) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheapflights Tip: The best prices from Chicago to Santiago Arturo Merino Benitez are usually found in April or August, booked 22 days in advance, depart on a Monday or Wednesday and return on a Monday

Cheap flight deals from Chicago to Santiago

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Chicago to Santiago

Cheapest flights from Chicago to SantiagoExplore the most affordable flight options available from Chicago to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Explore the most affordable flight options available from Chicago to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Chicago to Santiago that are best for you.

Best time to book a flight from Chicago to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Chicago with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Chicago to Santiago

How far ahead should I book a flight from Chicago to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Chicago to Santiago. Price data was last updated on September 12, 2025.

What is the cheapest month to book a flight from Chicago to Santiago?

What is the cheapest time of day to fly from CHI to SCL?

Find hourly flight availability from Chicago to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

How much does it cost to fly round-trip from Chicago to Santiago?

Reviews of airlines servicing Santiago

Read through reviews of airlines operating flights from Chicago to Santiago, such as Delta, Copa Airlines, and LATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Chicago to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Santiago from Chicago?

How long is the flight from Chicago to Santiago?

What are the cheapest airlines flying from Chicago to Santiago round-trip?

Can I find deals for flights from Chicago to Santiago that include hotel bookings?

How can I find direct flights from Chicago to Santiago?

Can I find deals for business class flights from Chicago to Santiago?

What is the cheapest month to book a flight from Chicago to Santiago?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Chicago to Santiago

See prices for flight routes from nearby airports that may be better suited for you.

Top 7 airlines flying from Chicago to Santiago

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Cheapest flights from Chicago to Santiago
Explore the most affordable flight options available from Chicago to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.