$307+ Cheap flights from Chicago (CHI) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHI — SCL
jun. 1 — jun. 81
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Chicago to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Chicago to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Chicago to SantiagoExplore the most affordable flight options available from Chicago to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on mai 2, 2026.
Explore the most affordable flight options available from Chicago to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on mai 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/275:11 pm
ORD
- SCL
2 stops56h 09m
Multiple Airlines
ma. 6/810:55 pm
SCL
- ORD
1 stop19h 16m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$679
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/19:20 am
ORD
- SCL
2 stops40h 15m
Multiple Airlines
sø. 6/1410:55 pm
SCL
- ORD
1 stop19h 16m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$696
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/184:44 pm
ORD
- SCL
2 stops32h 51m
Multiple Airlines
sø. 5/2410:55 pm
SCL
- ORD
1 stop19h 54m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$717
This FlightHub deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 6/91:46 pm
ORD
- SCL
2 stops14h 49m
LATAM Airlines
sø. 6/1410:55 pm
SCL
- ORD
1 stop19h 16m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$719
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/184:44 pm
ORD
- SCL
2 stops32h 51m
Multiple Airlines
on. 5/276:40 am
SCL
- ORD
1 stop15h 40m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$722
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 8/1512:44 am
ORD
- SCL
2 stops26h 11m
Multiple Airlines
on. 8/268:40 pm
SCL
- ORD
1 stop14h 24m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$723
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/203:55 pm
ORD
- SCL
2 stops29h 48m
Multiple Airlines
lø. 5/2310:55 pm
SCL
- ORD
1 stop19h 54m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$724
This FlightHub deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 6/211:26 am
ORD
- SCL
2 stops17h 09m
LATAM Airlines
ti. 6/910:55 pm
SCL
- ORD
1 stop19h 16m
LATAM Airlines
Deal found 4/29![LATAM Airlines logo]()
$725
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/184:44 pm
ORD
- SCL
2 stops32h 51m
Multiple Airlines
lø. 5/2311:17 am
SCL
- ORD
1 stop14h 58m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$727
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/203:55 pm
ORD
- SCL
2 stops29h 48m
Multiple Airlines
on. 5/276:40 am
SCL
- ORD
1 stop15h 40m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$729
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/184:44 pm
ORD
- SCL
2 stops32h 51m
Multiple Airlines
ma. 5/258:40 pm
SCL
- ORD
1 stop14h 36m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$731
This FlightHub deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 6/510:15 am
ORD
- SCL
2 stops18h 20m
LATAM Airlines
fr. 6/128:40 pm
SCL
- ORD
1 stop16h 59m
LATAM Airlines
Deal found 5/1![LATAM Airlines logo]()
$734
Best flights from Chicago to SantiagoDiscover carefully curated flight deals from Chicago to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated mai 2, 2026.
Discover carefully curated flight deals from Chicago to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated mai 2, 2026.
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 6/25:15 pm
MDW
- SCL
1 stop13h 00m
Delta
ti. 6/97:55 pm
SCL
- MDW
2 stops21h 21m
Delta
Deal found 5/2![Delta logo]()
$745
This Copa Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 6/168:02 am
ORD
- SCL
1 stop13h 41m
Copa Airlines
ti. 7/711:22 am
SCL
- ORD
1 stop17h 38m
Copa Airlines
Deal found 5/1![Copa Airlines logo]()
$767
This LATAM Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 5/298:10 am
ORD
- SCL
2 stops28h 25m
Multiple Airlines
lø. 6/206:00 pm
SCL
- ORD
2 stops45h 07m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$881
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 6/35:15 pm
MDW
- SCL
1 stop13h 00m
Delta
to. 6/118:40 pm
SCL
- MDW
1 stop16h 25m
Delta
Deal found 5/2![Delta logo]()
$745
This Copa Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/158:02 am
ORD
- SCL
1 stop20h 01m
Copa Airlines
ma. 7/611:22 am
SCL
- ORD
1 stop17h 38m
Copa Airlines
Deal found 4/28![Copa Airlines logo]()
$775
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/15:08 pm
MDW
- SCL
1 stop13h 07m
Delta
to. 6/118:40 pm
SCL
- MDW
1 stop16h 25m
Delta
Deal found 5/2![Delta logo]()
$745
This Copa Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 7/153:21 pm
ORD
- SCL
1 stop12h 42m
Copa Airlines
ti. 7/2111:22 am
SCL
- ORD
1 stop17h 38m
Copa Airlines
Deal found 4/29![Copa Airlines logo]()
$809
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 5/2112:53 pm
MDW
- SCL
1 stop17h 22m
Delta
ti. 5/268:40 pm
SCL
- MDW
1 stop16h 16m
Delta
Deal found 4/29![Delta logo]()
$752
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sø. 5/1712:53 pm
MDW
- SCL
1 stop17h 22m
Delta
on. 5/278:40 pm
SCL
- MDW
1 stop16h 16m
Delta
Deal found 4/30![Delta logo]()
$752
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 5/2910:59 am
MDW
- SCL
2 stops16h 51m
Delta
fr. 6/57:55 pm
SCL
- MDW
2 stops21h 40m
Delta
Deal found 5/1![Delta logo]()
$752
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/1810:59 am
MDW
- SCL
1 stop19h 16m
Delta
lø. 5/238:40 pm
SCL
- MDW
1 stop14h 19m
Delta
Deal found 4/30![Delta logo]()
$752
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/189:44 am
ORD
- SCL
1 stop19h 41m
Delta
lø. 5/238:40 pm
SCL
- ORD
1 stop15h 24m
Delta
Deal found 4/30![Delta logo]()
$752
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 5/306:31 pm
ORD
- SCL
1 stop34h 54m
Delta
ma. 6/810:55 pm
SCL
- ORD
1 stop21h 15m
Delta
Deal found 5/2![Delta logo]()
$753
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 6/11:22 pm
MDW
- SCL
2 stops16h 03m
Delta
ti. 6/98:40 pm
SCL
- MDW
2 stops17h 01m
Delta
Deal found 4/30![Delta logo]()
$757
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sø. 6/1412:45 pm
MDW
- SCL
1 stop17h 30m
Delta
sø. 6/218:40 pm
SCL
- MDW
1 stop20h 36m
Delta
Deal found 4/30![Delta logo]()
$787
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sø. 6/149:48 am
ORD
- SCL
2 stops18h 47m
Delta
sø. 6/2111:00 pm
SCL
- ORD
2 stops20h 42m
Delta
Deal found 4/30![Delta logo]()
$792
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 5/217:07 am
ORD
- SCL
1 stop23h 08m
Delta
ma. 5/258:40 pm
SCL
- ORD
1 stop18h 07m
Delta
Deal found 4/29![Delta logo]()
$813
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 7/239:45 am
ORD
- SCL
2 stops18h 05m
Delta
lø. 8/810:55 pm
SCL
- ORD
1 stop23h 57m
Delta
Deal found 4/29![Delta logo]()
$908
Last-minute flights from Chicago to SantiagoDiscover last-minute flight deals from Chicago to Santiago. Data last updated mai 2, 2026 and is based on user searches.
Discover last-minute flight deals from Chicago to Santiago. Data last updated mai 2, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/184:44 pm
ORD
- SCL
2 stops32h 51m
Multiple Airlines
sø. 5/2410:55 pm
SCL
- ORD
1 stop19h 54m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$717
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/184:44 pm
ORD
- SCL
2 stops32h 51m
Multiple Airlines
ti. 5/266:40 am
SCL
- ORD
1 stop15h 40m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$722
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/184:44 pm
ORD
- SCL
2 stops32h 51m
Multiple Airlines
lø. 5/2311:17 am
SCL
- ORD
1 stop14h 58m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$727
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/184:44 pm
ORD
- SCL
2 stops32h 51m
Multiple Airlines
ma. 5/258:40 pm
SCL
- ORD
1 stop14h 36m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$731
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/203:55 pm
ORD
- SCL
2 stops29h 48m
Multiple Airlines
lø. 5/2310:55 pm
SCL
- ORD
1 stop19h 54m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$724
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/203:55 pm
ORD
- SCL
2 stops29h 48m
Multiple Airlines
on. 5/276:40 am
SCL
- ORD
1 stop15h 40m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$729
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/203:55 pm
ORD
- SCL
2 stops29h 48m
Multiple Airlines
ma. 5/2512:38 am
SCL
- ORD
1 stop14h 28m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$736
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/203:55 pm
ORD
- SCL
2 stops29h 48m
Multiple Airlines
sø. 5/248:40 pm
SCL
- ORD
1 stop14h 36m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$738
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/275:11 pm
ORD
- SCL
2 stops56h 09m
Multiple Airlines
sø. 6/710:55 pm
SCL
- ORD
1 stop19h 16m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$679
This FlightHub deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 5/296:06 pm
ORD
- SCL
2 stops18h 19m
LATAM Airlines
ma. 6/111:00 pm
SCL
- ORD
2 stops18h 56m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$735
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sø. 5/315:10 pm
MDW
- SCL
1 stop13h 05m
Delta
to. 6/118:40 pm
SCL
- MDW
1 stop16h 25m
Delta
Deal found 5/2![Delta logo]()
$745
This KAYAK deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sø. 5/316:06 pm
ORD
- SCL
1 stop12h 09m
LATAM Airlines
sø. 6/74:50 pm
SCL
- ORD
2 stops25h 21m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$745
One-way flights from Chicago to SantiagoSearch for one-way flight options from Chicago to Santiago. Find affordable one-way fares based on user searches. Data last updated mai 2, 2026.
Search for one-way flight options from Chicago to Santiago. Find affordable one-way fares based on user searches. Data last updated mai 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/275:11 pm
ORD
- SCL
2 stops52h 32m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$307
This Cheapflightsfares deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
fr. 8/286:45 am
ORD
- SCL
1 stop15h 10m
Arajet
Deal found 5/2![Arajet logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 6/212:27 pm
MDW
- SCL
3 stops48h 03m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$351
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 6/21:29 pm
ORD
- SCL
3 stops47h 01m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$356
This eDestinos deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ma. 5/2512:33 am
ORD
- SCL
2 stops25h 02m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ti. 5/266:00 am
MDW
- SCL
3 stops44h 00m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 5/2712:04 pm
MDW
- SCL
3 stops57h 39m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
on. 6/101:29 pm
ORD
- SCL
3 stops36h 06m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 5/3012:59 pm
ORD
- SCL
3 stops47h 31m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 5/286:55 am
ORD
- SCL
3 stops38h 48m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lø. 8/812:44 am
ORD
- SCL
3 stops26h 11m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
to. 6/46:00 am
MDW
- SCL
3 stops36h 23m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$401
Find flight deals from Chicago to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Chicago (CHI) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated mai 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $696 (Kiwi.com) |
One-way from | $307 (Kiwi.com) |
Popular in | December |
Cheapest in | March |
Average price | $789 |
Cheapflights Fare Finder
Customize your flight search to find flights from Chicago to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mai 2, 2026.
Use the filters below to find and compare flights from Chicago to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
ti. 6/2
5:15 pm-7:15 am
1 stop13h 00m
Santiago Arturo Merino Benitez
ti. 6/9
7:55 pm-4:16 pm
2 stops21h 21m
$745
Quickest round-trip
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
on. 6/3
5:15 pm-7:15 am
1 stop13h 00m
Santiago Arturo Merino Benitez
to. 6/11
8:40 pm-12:05 pm
1 stop16h 25m
$745
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
ma. 6/1
5:08 pm-7:15 am
1 stop13h 07m
Santiago Arturo Merino Benitez
to. 6/11
8:40 pm-12:05 pm
1 stop16h 25m
$745
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
to. 5/21
12:53 pm-7:15 am
1 stop17h 22m
Santiago Arturo Merino Benitez
ti. 5/26
8:40 pm-11:56 am
1 stop16h 16m
$752
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
sø. 5/17
12:53 pm-7:15 am
1 stop17h 22m
Santiago Arturo Merino Benitez
on. 5/27
8:40 pm-11:56 am
1 stop16h 16m
$752
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
fr. 5/29
10:59 am-4:50 am
2 stops16h 51m
Santiago Arturo Merino Benitez
fr. 6/5
7:55 pm-4:35 pm
2 stops21h 40m
$752
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
ma. 5/18
10:59 am-7:15 am
1 stop19h 16m
Santiago Arturo Merino Benitez
lø. 5/23
8:40 pm-9:59 am
1 stop14h 19m
$752
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
ma. 5/18
9:44 am-6:25 am
1 stop19h 41m
Santiago Arturo Merino Benitez
lø. 5/23
8:40 pm-11:04 am
1 stop15h 24m
$752
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
lø. 5/30
6:31 pm-6:25 am
1 stop34h 54m
Santiago Arturo Merino Benitez
ma. 6/8
10:55 pm-7:10 pm
1 stop21h 15m
$753
ChicagoSantiago
MDW - SCL
MDWSCL
Chicago Midway
ma. 6/1
1:22 pm-6:25 am
2 stops16h 03m
Santiago Arturo Merino Benitez
ti. 6/9
8:40 pm-12:41 pm
2 stops17h 01m
$757
Showing 1-10 of 36 resultsSorted by cheapest first
Compare providers for flights from Chicago to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Chicago to Santiago in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Chicago-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Chicago to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Chicago with our price prediction graph.
CHI-SCL
MDW-SCL
ORD-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago to Santiago
CHI-SCL
MDW-SCL
ORD-SCL
How far ahead should I book a flight from Chicago to Santiago?
The price you pay for your flight from Chicago to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 89 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Chicago to Santiago?
Currently, March is the cheapest month in which you can book a flight from Chicago to Santiago (average of $302). Flying from Chicago to Santiago in October is currently the most expensive (average of $645). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Chicago to Santiago?
What’s the top layover airport for flights from Chicago to Santiago?
Share of 1-stop round-trip flights from Chicago to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Panama City (PTY) – chosen by Cheapflights users on 71% of 1-stop itineraries from Chicago to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from Chicago to Santiago?
Average round-trip fare for 1-stop flights from Chicago to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Bogotá (BOG) is the most affordable 1-stop option, with an average round-trip price of $558.
What’s the fastest layover option from Chicago to Santiago?
Shortest average travel time for 1-stop one-way flights from Chicago to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Panama City (PTY) have the shortest average one-way travel time for 1-stop routes: 12h 38m.
Which airport typically offers the quickest layover for flights from Chicago to Santiago?
Average layover duration for 1-stop one-way flights from Chicago to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Panama City (PTY) offer the fastest connection on this route, with an average layover time of 1h 24m.
How often are flights from Chicago to Santiago delayed?
About 0% of weekly flights between Chicago and Santiago have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Chicago to Santiago flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Wednesday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated mai 2, 2026.
Read through reviews of airlines operating flights from Chicago to Santiago, such as Delta,Copa Airlines, andLATAM Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.9
Food
7.2
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Chicago to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Chicago
Popular flights
Santiago flight routes
Alternative routes for Chicago to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Chicago to Santiago by cabin class
Find flights from Chicago to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Chicago and Santiago flights
Browse other Chicago and Santiago flight options. Last updated on mai 2, 2026.
Other flights from Chicago
Browse through other flights departing from Chicago. Flights are based on user searches made on Cheapflights and were last updated on mai 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on mai 2, 2026.
Top 6 airlines flying from Chicago to Santiago
Discover the top 6 airlines that operate flights from Chicago to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mai 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$537 | Average$680 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$540 | Average$740 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$567 | Average$774 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$568 | Average$823 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$597 | Average$890 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$626 | Average$796 | FlexibilityNo cancel fee | On-time69% |