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$145+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Dec 14 — Dec 211
Sun 12/14
Sun 12/21
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty are usually found in February or September, booked 90 days in advance, depart on a Saturday or Friday and return on a Saturday

Cheap flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 14, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$296
(Kiwi.com)

One-way from

$145
(Delta)

Popular in

November

Cheapest in

February

Average price

$633
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flights.
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From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
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One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
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Highest demand for flights based on searches. 25% potential increase in price ($146 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/214:48 pmTYS - SNA
2 stops25h 00mFrontier
Mon 11/2412:04 pmSNA - TYS
1 stop24h 49mFrontier
Deal found 11/12$291
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:30 amTYS - SNA
2 stops36h 29mMultiple Airlines
Mon 11/2412:04 pmSNA - TYS
1 stop24h 49mMultiple Airlines
Deal found 11/12$349
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/218:30 amTYS - SNA
1 stop10h 29mMultiple Airlines
Mon 11/2412:04 pmSNA - TYS
1 stop24h 49mMultiple Airlines
Deal found 11/12$361
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:57 pmTYS - SNA
1 stop9h 33mDelta
Sun 12/1412:45 pmSNA - TYS
1 stop7h 43mDelta
Deal found 11/12$437
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:30 amTYS - SNA
1 stop7h 49mMultiple Airlines
Sun 11/2310:07 amSNA - TYS
1 stop9h 30mMultiple Airlines
Deal found 11/13$445
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:24 amTYS - SNA
1 stop7h 19mAmerican Airlines
Sun 12/1412:28 pmSNA - TYS
2 stops8h 22mAmerican Airlines
Deal found 11/12$460
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/297:00 amTYS - SNA
1 stop8h 33mMultiple Airlines
Wed 12/35:46 pmSNA - TYS
2 stops25h 36mMultiple Airlines
Deal found 11/13$490

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 14, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Knoxville

Fly to

Santa Ana

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 11/21

4:48 pm-2:48 pm

2 stops25h 00m

Santa Ana J. Wayne/Orange Cnty

Mon 11/24

12:04 pm-3:53 pm

1 stop24h 49m

$291

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 11/20

6:30 am-3:59 pm

2 stops36h 29m

Santa Ana J. Wayne/Orange Cnty

Mon 11/24

12:04 pm-3:53 pm

1 stop24h 49m

$349

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 11/21

8:30 am-3:59 pm

1 stop10h 29m

Santa Ana J. Wayne/Orange Cnty

Mon 11/24

12:04 pm-3:53 pm

1 stop24h 49m

$361

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 1/1

5:23 am-9:58 am

1 stop7h 35m

Santa Ana J. Wayne/Orange Cnty

Tue 1/6

12:38 pm-10:47 pm

2 stops7h 09m

$386

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 12/12

3:57 pm-10:30 pm

1 stop9h 33m

Santa Ana J. Wayne/Orange Cnty

Sun 12/14

12:45 pm-11:28 pm

1 stop7h 43m

$437

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 1/23

4:06 pm-10:14 pm

1 stop9h 08m

Santa Ana J. Wayne/Orange Cnty

Sun 1/25

9:20 pm-9:21 am

1 stop9h 01m

$437

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 11/20

6:30 am-11:19 am

1 stop7h 49m

Santa Ana J. Wayne/Orange Cnty

Sun 11/23

10:07 am-10:37 pm

1 stop9h 30m

$445

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 12/17

6:29 am-1:00 pm

1 stop9h 31m

$145

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 12/10

12:53 pm-10:44 am

3 stops24h 51m

$154

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 12/16

6:00 pm-10:30 pm

1 stop7h 30m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/13

Showing 1-10 of 16 results
1
2

Compare providers for flights from Knoxville to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana, California?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on November 7, 2025.

Booking 70 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana, California. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $151). Flying from Knoxville to Santa Ana, California in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SNA?

Find hourly flight availability from Knoxville to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 14, 2025.

When flying from Knoxville to Santa Ana, California, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 41% versus a flight in the afternoon.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated November 14, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Food

7.3

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Food

7.3

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Food

7.3

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Food

7.3

Overall

7.9

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Ana, California?

    Departing from Knoxville to Santa Ana, California will take you 7h 35m. There are 1918 mi between Knoxville and Santa Ana, California. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Santa Ana, California round-trip?

    Currently priced at $256, United Airlines will fly you from Knoxville to Santa Ana, California and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Delta - these airlines can fly you to your destination from $258 and $282, respectively. You may be able to fly from Knoxville to Santa Ana, California for 38% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $151). Flying from Knoxville to Santa Ana, California in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

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Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$256Average$498FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$428FlexibilityNo cancel feeOn-time71%
DeltaCheapest$282Average$390FlexibilityNo cancel feeOn-timeN/A

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