HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Ana

$110+ Cheap flights from Knoxville to Santa Ana (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Santa Ana with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty are usually found in February or April, booked 89 days in advance, depart on a Saturday or Friday and return on a Saturday

Cheap flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$289
(American Airlines)

One-way from

$110
(Mytrip)

Popular in

October

Cheapest in

February

Average price

$428
From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($64 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/226:00 amTYS - SNA
1 stop7h 39mAmerican Airlines
Tue 7/2912:27 pmSNA - TYS
1 stop8h 25mAmerican Airlines
Deal found 6/11$289
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:03 amTYS - SNA
1 stop7h 03mUnited Airlines
Tue 10/711:32 amSNA - TYS
2 stops9h 11mUnited Airlines
Deal found 6/10$294
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/225:30 amTYS - SNA
2 stops13h 40mDelta
Tue 7/297:11 pmSNA - TYS
2 stops12h 03mDelta
Deal found 6/11$299
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/66:34 pmTYS - SNA
2 stops30h 16mMultiple Airlines
Wed 7/97:58 pmSNA - TYS
3 stops24h 39mMultiple Airlines
Deal found 6/10$308
This FlightHub deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/148:26 pmTYS - SNA
1 stop18h 07mFrontier
Sun 9/2112:18 pmSNA - TYS
1 stop28h 23mFrontier
Deal found 6/10$378
This Alaska Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/17:28 amTYS - SNA
2 stops17h 14mAlaska Airlines
Tue 10/77:55 amSNA - TYS
2 stops12h 52mAlaska Airlines
Deal found 6/10$489

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Knoxville

Fly to

Santa Ana

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/22

6:00 am-10:39 am

1 stop7h 39m

Santa Ana J. Wayne/Orange Cnty

Tue 7/29

12:27 pm-11:52 pm

1 stop8h 25m

$289

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/22

5:30 am-10:50 am

1 stop8h 20m

Santa Ana J. Wayne/Orange Cnty

Tue 7/29

7:11 pm-10:14 am

2 stops12h 03m

$294

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 7/6

6:34 pm-9:50 pm

2 stops30h 16m

Santa Ana J. Wayne/Orange Cnty

Wed 7/9

7:58 pm-11:37 pm

3 stops24h 39m

$308

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/1

4:35 pm-10:09 pm

1 stop8h 34m

Santa Ana J. Wayne/Orange Cnty

Sat 7/5

12:00 pm-11:27 pm

1 stop8h 27m

$382

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 6/26

5:25 pm-11:16 am

1 stop20h 51m

Santa Ana J. Wayne/Orange Cnty

Sat 6/28

12:01 pm-4:29 pm

1 stop25h 28m

$518

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 7/17

8:08 am-8:25 pm

2 stops15h 17m

Santa Ana J. Wayne/Orange Cnty

Tue 7/22

7:00 am-9:46 pm

2 stops11h 46m

$789

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 9/15

8:30 am-10:01 am

1 stop28h 31m

$110

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 8/10

5:25 pm-11:10 am

1 stop20h 45m

$197

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 10/5

4:40 pm-12:17 pm

3 stops22h 37m

$639

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/9

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on June 9, 2025.

Booking 72 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $298). Flying from Knoxville to Santa Ana in March is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SNA?

Find hourly flight availability from Knoxville to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Knoxville to Santa Ana, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 19% versus a flight in the afternoon.

Rainfall in Santa Ana by month

Plan your trip to Santa Ana by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santa Ana ranges from 0.0 - 3.1 inches per month. February is typically the wettest month, when rainfall can reach 3.1 in. July is typically the driest time to visit Santa Ana when rainfall is around 0.0 in.

Temperature in Santa Ana by month

Plan your trip to Santa Ana by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santa Ana, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 55.4 F).

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated June 12, 2025.
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,950 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,790 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
5.9
Fair
3,295 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Comfort

7.8

Food

7.1

Overall

8.0

Entertainment

7.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Santa Ana round-trip?

    Flying on American Airlines is currently your cheapest option to Santa Ana, with prices starting at $289. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $294 and $299, respectively. You may be able to fly from Knoxville to Santa Ana for 29% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $298). Flying from Knoxville to Santa Ana in March is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Tustin

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Santa Ana

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Las Vegas flights
Nashville to Los Angeles flights
Memphis to Las Vegas flights
Memphis to Los Angeles flights
Nashville to San Francisco flights
Nashville to Santa Ana flights
Nashville to Ontario flights
Nashville to Burbank flights
Nashville to San Diego flights
Chattanooga to Las Vegas flights
Memphis to Santa Ana flights
Nashville to Sacramento flights
Memphis to Ontario flights
Memphis to Burbank flights
Memphis to San Francisco flights
Knoxville to Los Angeles flights
Memphis to San Diego flights
Knoxville to San Diego flights
Knoxville to Las Vegas flights
Nashville to San Jose flights
Nashville to Oakland flights
Memphis to Long Beach flights
Knoxville to San Francisco flights
Nashville to Fresno flights
Chattanooga to Los Angeles flights
Chattanooga to San Francisco flights
Knoxville to Ontario flights
Nashville to Reno flights
Nashville to Long Beach flights
Knoxville to Sacramento flights
Memphis to San Jose flights
Chattanooga to Ontario flights
Nashville to Palm Springs flights
Blountville to Las Vegas flights
Memphis to Fresno flights
Memphis to Reno flights
Knoxville to San Luis Obispo flights
Memphis to Oakland flights
Blountville to Los Angeles flights
Chattanooga to San Diego flights
Knoxville to Reno flights
Knoxville to Burbank flights
Nashville to Santa Barbara flights
Nashville to Monterey flights
Knoxville to San Jose flights
Nashville to Medford flights
Chattanooga to Sacramento flights
Chattanooga to Santa Ana flights
Knoxville to Long Beach flights

Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$242Average$423FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$524FlexibilityNo cancel feeOn-time69%
DeltaCheapest$282Average$395FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.