$143+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Jul 7 — Jul 141
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to Santa AnaExplore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 7, 2026.
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:30 am
TYS
- SNA
1 stop12h 45m
Multiple Airlines
Thu 9/244:50 pm
SNA
- TYS
1 stop20h 08m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$336
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:00 am
TYS
- SNA
1 stop28h 05m
Multiple Airlines
Tue 8/111:00 pm
SNA
- TYS
1 stop26h 28m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- SNA
1 stop20h 05m
Multiple Airlines
Wed 7/84:13 pm
SNA
- TYS
2 stops40h 50m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:45 am
TYS
- SNA
1 stop7h 29m
United Airlines
Tue 11/31:20 pm
SNA
- TYS
1 stop6h 00m
United Airlines
Deal found 6/5![United Airlines logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:00 am
TYS
- SNA
1 stop28h 09m
Multiple Airlines
Wed 7/84:13 pm
SNA
- TYS
2 stops40h 50m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:50 pm
TYS
- SNA
2 stops10h 05m
Southwest
Tue 11/37:45 am
SNA
- TYS
2 stops8h 05m
Southwest
Deal found 6/4![Southwest logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:30 am
TYS
- SNA
2 stops10h 42m
Multiple Airlines
Mon 10/267:30 am
SNA
- TYS
1 stop10h 22m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:20 pm
TYS
- SNA
1 stop23h 05m
Multiple Airlines
Wed 7/154:13 pm
SNA
- TYS
2 stops40h 50m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am
TYS
- SNA
1 stop10h 32m
Multiple Airlines
Thu 10/87:30 am
SNA
- TYS
1 stop12h 31m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$393
Best flights from Knoxville to Santa AnaDiscover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 7, 2026.
Discover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 7, 2026.
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/278:45 am
TYS
- SNA
1 stop7h 29m
United Airlines
Tue 11/31:20 pm
SNA
- TYS
1 stop6h 00m
United Airlines
Deal found 6/5![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:50 pm
TYS
- SNA
1 stop8h 15m
Southwest
Tue 11/37:45 am
SNA
- TYS
2 stops8h 05m
Southwest
Deal found 6/5![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:57 pm
TYS
- SNA
1 stop7h 32m
Delta
Sun 11/17:45 am
SNA
- TYS
1 stop6h 33m
Delta
Deal found 6/6![Delta logo]()
$457
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:20 pm
TYS
- SNA
1 stop7h 05m
Southwest
Fri 7/108:35 am
SNA
- TYS
2 stops9h 40m
Southwest
Deal found 6/6![Southwest logo]()
$418
This Delta deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:35 am
TYS
- SNA
1 stop9h 19m
Delta
Wed 9/1611:38 am
SNA
- TYS
1 stop9h 12m
Delta
Deal found 6/4![Delta logo]()
$472
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:00 am
TYS
- SNA
2 stops9h 05m
Southwest
Thu 7/98:35 am
SNA
- TYS
2 stops9h 40m
Southwest
Deal found 6/5![Southwest logo]()
$443
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/229:00 am
TYS
- SNA
1 stop7h 05m
United Airlines
Wed 8/2611:10 am
SNA
- TYS
1 stop8h 19m
United Airlines
Deal found 6/4![United Airlines logo]()
$494
This Southwest deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:00 pm
TYS
- SNA
2 stops9h 15m
Southwest
Mon 10/268:15 am
SNA
- TYS
2 stops7h 25m
Southwest
Deal found 6/4![Southwest logo]()
$448
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:11 pm
TYS
- SNA
1 stop6h 53m
Delta
Sun 9/2711:38 am
SNA
- TYS
1 stop9h 12m
Delta
Deal found 6/2![Delta logo]()
$546
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:02 pm
TYS
- SNA
1 stop7h 23m
United Airlines
Wed 9/166:32 pm
SNA
- TYS
2 stops12h 25m
United Airlines
Deal found 6/3![United Airlines logo]()
$548
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- SNA
2 stops19h 05m
Delta
Wed 7/82:00 pm
SNA
- TYS
1 stop6h 52m
Delta
Deal found 6/2![Delta logo]()
$547
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/54:20 pm
TYS
- SNA
2 stops9h 05m
Southwest
Sun 7/127:50 pm
SNA
- TYS
2 stops13h 10m
Southwest
Deal found 6/6![Southwest logo]()
$550
Last-minute flights from Knoxville to Santa AnaDiscover last-minute flight deals from Knoxville to Santa Ana. Data last updated June 7, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santa Ana. Data last updated June 7, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:00 am
TYS
- SNA
1 stop28h 09m
Multiple Airlines
Tue 7/74:13 pm
SNA
- TYS
2 stops23h 12m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$400
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2910:03 pm
TYS
- SNA
1 stop17h 12m
Multiple Airlines
Tue 7/74:13 pm
SNA
- TYS
2 stops23h 12m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:45 pm
TYS
- SNA
1 stop22h 40m
Multiple Airlines
Tue 7/74:13 pm
SNA
- TYS
2 stops23h 12m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:37 am
TYS
- SNA
1 stop7h 07m
American Airlines
Wed 7/82:24 pm
SNA
- TYS
1 stop6h 27m
American Airlines
Deal found 6/2![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:54 pm
TYS
- SNA
1 stop9h 34m
Delta
Wed 7/82:00 pm
SNA
- TYS
1 stop6h 52m
Delta
Deal found 6/2![Delta logo]()
$394
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:00 am
TYS
- SNA
1 stop28h 09m
Multiple Airlines
Wed 7/84:13 pm
SNA
- TYS
2 stops40h 50m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- SNA
1 stop20h 05m
Multiple Airlines
Wed 7/84:13 pm
SNA
- TYS
2 stops40h 50m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- SNA
1 stop20h 05m
Multiple Airlines
Thu 7/167:53 pm
SNA
- TYS
2 stops35h 09m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- SNA
1 stop20h 05m
Multiple Airlines
Thu 7/97:53 pm
SNA
- TYS
2 stops35h 04m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/37:20 pm
TYS
- SNA
1 stop20h 05m
Multiple Airlines
Sat 7/1110:55 am
SNA
- TYS
2 stops55h 20m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- SNA
1 stop9h 40m
Delta
Wed 7/82:00 pm
SNA
- TYS
1 stop6h 52m
Delta
Deal found 6/2![Delta logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:20 pm
TYS
- SNA
1 stop23h 05m
Multiple Airlines
Wed 7/154:13 pm
SNA
- TYS
2 stops40h 50m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$391
One-way flights from Knoxville to Santa AnaSearch for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated June 7, 2026.
Search for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated June 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:00 am
TYS
- SNA
1 stop28h 05m
Multiple Airlines
Deal found 6/2![Multiple Airlines logo]()
$143
This Booking.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:19 pm
TYS
- SNA
1 stop17h 09m
Frontier
Deal found 6/2![Frontier logo]()
$167
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:00 am
TYS
- SNA
1 stop10h 32m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$179
This American Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:31 pm
TYS
- SNA
1 stop7h 53m
American Airlines
Deal found 6/2![American Airlines logo]()
$185
This Trip.com deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:32 pm
TYS
- SNA
1 stop15h 57m
Frontier
Deal found 6/2![Frontier logo]()
$186
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/287:10 am
TYS
- SNA
2 stops10h 40m
Southwest
Deal found 6/2![Southwest logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:00 am
TYS
- SNA
2 stops35h 01m
Multiple Airlines
Deal found 6/3![Multiple Airlines logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:20 pm
TYS
- SNA
3 stops48h 22m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$196
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:37 am
TYS
- SNA
1 stop6h 56m
American Airlines
Deal found 6/6![American Airlines logo]()
$229
This Southwest deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/72:45 pm
TYS
- SNA
2 stops10h 10m
Southwest
Deal found 6/2![Southwest logo]()
$234
Find flight deals from Knoxville to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $336 (Kiwi.com) |
One-way from | $143 (Kiwi.com) |
Popular in | January |
Cheapest in | September |
Average price | $403 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Tue 10/27
8:45 am-1:14 pm
1 stop7h 29m
Santa Ana J. Wayne/Orange Cnty
Tue 11/3
1:20 pm-10:20 pm
1 stop6h 00m
$369
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Tue 10/27
1:50 pm-7:05 pm
1 stop8h 15m
Santa Ana J. Wayne/Orange Cnty
Tue 11/3
7:45 am-6:50 pm
2 stops8h 05m
$374
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Fri 7/3
4:20 pm-8:25 pm
1 stop7h 05m
Santa Ana J. Wayne/Orange Cnty
Fri 7/10
8:35 am-9:15 pm
2 stops9h 40m
$418
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Sat 7/4
7:00 am-1:05 pm
2 stops9h 05m
Santa Ana J. Wayne/Orange Cnty
Thu 7/9
8:35 am-9:15 pm
2 stops9h 40m
$443
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Thu 10/22
4:00 pm-10:15 pm
2 stops9h 15m
Santa Ana J. Wayne/Orange Cnty
Mon 10/26
8:15 am-6:40 pm
2 stops7h 25m
$448
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Fri 10/23
5:57 pm-10:29 pm
1 stop7h 32m
Santa Ana J. Wayne/Orange Cnty
Sun 11/1
7:45 am-5:18 pm
1 stop6h 33m
$457
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Mon 9/14
6:35 am-12:54 pm
1 stop9h 19m
Santa Ana J. Wayne/Orange Cnty
Wed 9/16
11:38 am-11:50 pm
1 stop9h 12m
$472
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Sat 8/22
9:00 am-1:05 pm
1 stop7h 05m
Santa Ana J. Wayne/Orange Cnty
Wed 8/26
11:10 am-10:29 pm
1 stop8h 19m
$494
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Mon 9/21
6:11 pm-10:04 pm
1 stop6h 53m
Santa Ana J. Wayne/Orange Cnty
Sun 9/27
11:38 am-11:50 pm
1 stop9h 12m
$546
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Sat 7/4
6:00 am-10:05 pm
2 stops19h 05m
Santa Ana J. Wayne/Orange Cnty
Wed 7/8
2:00 pm-11:52 pm
1 stop6h 52m
$547
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
TYS-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Santa Ana
How far ahead should I book a flight from Knoxville to Santa Ana, California?
Booking 10 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana, California. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Knoxville to Santa Ana, California?
Currently, September is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $378). Flying from Knoxville to Santa Ana, California in January is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Santa Ana, California?
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated June 7, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.9
Crew
8.5
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Knoxville and Santa Ana flights
Browse other Knoxville and Santa Ana flight options. Last updated on June 7, 2026.
Other flights from Knoxville
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Top 3 airlines flying from Knoxville to Santa Ana
Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$274 | Average$398 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$498 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$288 | Average$496 | FlexibilityNo cancel fee | On-time71% |