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Santa Ana

$155+ Cheap flights from Knoxville to Santa Ana (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:05 am
TYS
-
SNA
1 stop7h 08m
United Airlines
Tue 4/712:15 pm
SNA
-
TYS
1 stop8h 26m
United Airlines
Deal found 3/5$289
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:54 pm
TYS
-
SNA
1 stop6h 51m
American Airlines
Tue 4/281:23 pm
SNA
-
TYS
1 stop7h 33m
American Airlines
Deal found 3/5$309
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:05 am
TYS
-
SNA
1 stop7h 08m
United Airlines
Tue 4/289:00 am
SNA
-
TYS
2 stops10h 34m
United Airlines
Deal found 3/7$314
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:40 am
TYS
-
SNA
1 stop9h 17m
American Airlines
Tue 4/72:42 pm
SNA
-
TYS
1 stop6h 14m
American Airlines
Deal found 3/6$331
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/82:55 pm
TYS
-
SNA
1 stop9h 00m
Southwest
Mon 4/139:10 pm
SNA
-
TYS
2 stops11h 50m
Southwest
Deal found 3/8$342
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:51 pm
TYS
-
SNA
1 stop9h 41m
American Airlines
Tue 7/282:29 pm
SNA
-
TYS
1 stop6h 16m
American Airlines
Deal found 3/6$354
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
-
SNA
1 stop21h 16m
Multiple Airlines
Sun 4/267:56 pm
SNA
-
TYS
1 stop23h 55m
Multiple Airlines
Deal found 3/5$358
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/144:56 pm
TYS
-
SNA
1 stop6h 44m
United Airlines
Tue 7/2810:20 am
SNA
-
TYS
2 stops11h 10m
United Airlines
Deal found 3/6$369
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:57 pm
TYS
-
SNA
1 stop7h 31m
Delta
Sat 7/42:00 pm
SNA
-
TYS
1 stop6h 46m
Delta
Deal found 3/6$373

Find flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$289
(United Airlines)

One-way from

$155
(American Airlines)

Popular in

January

Cheapest in

May

Average price

$526
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flights.
Search Deals
From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($96 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 4/22

4:30 pm-9:58 pm

1 stop8h 28m

Santa Ana J. Wayne/Orange Cnty

Tue 4/28

6:39 pm-10:08 am

2 stops12h 29m

$384
Quickest round-trip

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 4/14

9:00 am-1:36 pm

1 stop7h 36m

Santa Ana J. Wayne/Orange Cnty

Sat 4/18

11:10 am-10:29 pm

1 stop8h 19m

$399
Cheapest one-way
Quickest one-way

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 4/22

6:54 pm-10:45 pm

1 stop6h 51m

$155

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 4/22

11:25 am-8:55 pm

2 stops12h 30m

$160

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 3/31

7:05 am-3:03 pm

2 stops10h 58m

$182

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 6/28

2:42 pm-1:52 pm

1 stop26h 10m

$197

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 5/29

12:27 pm-10:29 am

2 stops25h 02m

$202

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 6/28

1:22 pm-9:48 am

2 stops23h 26m

$215

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 5/29

3:40 pm-8:05 pm

1 stop7h 25m

$229

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 7/7

5:57 pm-10:14 pm

1 stop7h 17m

$240

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/7

Sorted by cheapest first

Compare providers for flights from Knoxville to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Ana flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Ana flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on March 6, 2026.

Booking 23 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $88). Flying from Knoxville to Santa Ana in January is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated March 10, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,276 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,409 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.1
Good
11,413 reviews
Delta
7.9
Good
8,276 reviews

Comfort

7.9

Crew

8.5

Overall

7.9

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Ana?

    Airlines like United Airlines fly from Knoxville to Santa Ana in about 8h 28m. The time it takes to get you to your destination can typically vary by up to . There are 1918 mi between Knoxville and Santa Ana.

  • What are the cheapest airlines flying from Knoxville to Santa Ana round-trip?

    Flying on Delta is currently your cheapest option to Santa Ana, with prices starting at $282. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $288 and $288, respectively. You may be able to fly from Knoxville to Santa Ana for 40% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $88). Flying from Knoxville to Santa Ana in January is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

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Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$282Average$417FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$288Average$498FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$288Average$458FlexibilityNo cancel feeOn-time71%

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