HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Ana

$139+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Feb 1 — Feb 81
Sun 2/1
Sun 2/8
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Santa Ana with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Santa Ana

Best flights from Knoxville to Santa Ana
Discover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 2, 2026.

This Kiwi.com deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/161:40 pmTYS - SNA
1 stop25h 45mMultiple Airlines
Sat 2/216:45 amSNA - TYS
2 stops31h 37mMultiple Airlines
Deal found 12/31$311
This American Airlines deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/47:54 amTYS - SNA
1 stop8h 10mAmerican Airlines
Sun 2/812:52 pmSNA - TYS
1 stop6h 55mAmerican Airlines
Deal found 1/1$357
This United Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:30 pmTYS - SNA
1 stop8h 28mUnited Airlines
Tue 4/712:15 pmSNA - TYS
1 stop8h 26mUnited Airlines
Deal found 12/31$379
This Delta deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/145:40 amTYS - SNA
1 stop9h 09mDelta
Wed 1/2111:55 amSNA - TYS
1 stop8h 50mDelta
Deal found 12/30$423
This Kiwi.com deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1110:58 amTYS - SNA
2 stops24h 15mMultiple Airlines
Sun 2/156:15 pmSNA - TYS
1 stop25h 46mMultiple Airlines
Deal found 12/30$350
This Kiwi.com deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1510:00 amTYS - SNA
1 stop11h 14mMultiple Airlines
Sat 1/173:55 pmSNA - TYS
2 stops22h 58mMultiple Airlines
Deal found 12/31$366
This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/264:25 pmTYS - SNA
1 stop7h 53mUnited Airlines
Thu 1/2910:51 amSNA - TYS
1 stop7h 01mUnited Airlines
Deal found 12/30$421
This Kiwi.com deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/44:47 pmTYS - SNA
2 stops23h 57mMultiple Airlines
Sun 2/812:17 pmSNA - TYS
1 stop24h 18mMultiple Airlines
Deal found 1/1$379

Find flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 2, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$279
(Kiwi.com)

One-way from

$139
(United Airlines)

Popular in

November

Cheapest in

February

Average price

$378
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flights.
Search Deals
From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($149 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 2, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Knoxville

Fly to

Santa Ana

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 2/16

1:40 pm-12:25 pm

1 stop25h 45m

Santa Ana J. Wayne/Orange Cnty

Sat 2/21

6:45 am-5:22 pm

2 stops31h 37m

$311

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 2/11

10:58 am-8:13 am

2 stops24h 15m

Santa Ana J. Wayne/Orange Cnty

Sun 2/15

6:15 pm-11:01 pm

1 stop25h 46m

$350

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 2/4

7:54 am-1:04 pm

1 stop8h 10m

Santa Ana J. Wayne/Orange Cnty

Sun 2/8

12:52 pm-10:47 pm

1 stop6h 55m

$357

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 1/15

10:00 am-6:14 pm

1 stop11h 14m

Santa Ana J. Wayne/Orange Cnty

Sat 1/17

3:55 pm-5:53 pm

2 stops22h 58m

$366

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 4/1

4:30 pm-9:58 pm

1 stop8h 28m

Santa Ana J. Wayne/Orange Cnty

Tue 4/7

12:15 pm-11:41 pm

1 stop8h 26m

$379

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 2/4

4:47 pm-1:44 pm

2 stops23h 57m

Santa Ana J. Wayne/Orange Cnty

Sun 2/8

12:17 pm-3:35 pm

1 stop24h 18m

$379

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 1/26

4:25 pm-9:18 pm

1 stop7h 53m

Santa Ana J. Wayne/Orange Cnty

Thu 1/29

10:51 am-8:52 pm

1 stop7h 01m

$421

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 1/14

5:40 am-11:49 am

1 stop9h 09m

Santa Ana J. Wayne/Orange Cnty

Wed 1/21

11:55 am-11:45 pm

1 stop8h 50m

$423

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 2/3

4:25 pm-9:18 pm

1 stop7h 53m

$139

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 2/3

1:00 pm-10:58 am

2 stops48h 58m

$140

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/1

Showing 1-10 of 20 results
1
2

Compare providers for flights from Knoxville to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana, California?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on December 26, 2025.

Booking 88 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana, California. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $142). Flying from Knoxville to Santa Ana, California in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated January 2, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,021 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Overall

7.9

Comfort

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,021 reviews
Delta
7.9
Good
8,021 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Overall

7.9

Comfort

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,132 reviews
Delta
7.9
Good
8,021 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Overall

7.9

Comfort

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,075 reviews
Delta
7.9
Good
8,021 reviews

Entertainment

7.8

Crew

8.5

Boarding

8.1

Overall

7.9

Comfort

7.9

Food

7.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Ana, California?

    Departing from Knoxville to Santa Ana, California will take you 8h 10m. There are 1918 mi between Knoxville and Santa Ana, California.

  • What are the cheapest airlines flying from Knoxville to Santa Ana, California round-trip?

    Currently priced at $258, United Airlines will fly you from Knoxville to Santa Ana, California and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Delta - these airlines can fly you to your destination from $269 and $282, respectively. You may be able to fly from Knoxville to Santa Ana, California for 39% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $142). Flying from Knoxville to Santa Ana, California in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Santa Ana

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Los Angeles flights
Nashville to Las Vegas flights
Memphis to Las Vegas flights
Memphis to Los Angeles flights
Nashville to San Francisco flights
Chattanooga to Las Vegas flights
Nashville to Ontario flights
Nashville to San Diego flights
Nashville to Burbank flights
Memphis to San Diego flights
Nashville to Santa Ana flights
Memphis to Ontario flights
Knoxville to Las Vegas flights
Knoxville to Los Angeles flights
Nashville to Sacramento flights
Nashville to Palm Springs flights
Nashville to San Jose flights
Knoxville to San Francisco flights
Nashville to Reno flights
Chattanooga to Los Angeles flights
Memphis to San Francisco flights
Memphis to Santa Ana flights
Knoxville to San Diego flights
Memphis to Palm Springs flights
Chattanooga to Ontario flights
Nashville to Long Beach flights
Knoxville to Ontario flights
Nashville to Santa Barbara flights
Blountville to Las Vegas flights
Blountville to Los Angeles flights
Knoxville to San Jose flights
Nashville to Fresno flights
Memphis to San Jose flights
Nashville to Medford flights
Chattanooga to San Francisco flights
Knoxville to Reno flights
Knoxville to Sacramento flights
Memphis to Sacramento flights
Chattanooga to Santa Ana flights
Memphis to Long Beach flights
Memphis to Burbank flights
Chattanooga to San Diego flights
Knoxville to Monterey flights
Knoxville to Bakersfield flights
Nashville to San Luis Obispo flights
Chattanooga to Long Beach flights
Blountville to San Francisco flights
Chattanooga to Sacramento flights
Nashville to Oakland flights

Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$258Average$479FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$269Average$428FlexibilityNo cancel feeOn-time71%
DeltaCheapest$282Average$388FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.