$145+ Cheap flights from Knoxville to Santa Ana (TYS - SNA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Mar 25 — Apr 11
1 adult, Economy
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Find cheap flights from Knoxville to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santa Ana
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Cheapest flights from Knoxville to Santa AnaExplore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2026.
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:29 pm
TYS
- SNA
1 stop6h 54m
American Airlines
Tue 3/318:17 am
SNA
- TYS
1 stop6h 14m
American Airlines
Deal found 2/19![American Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:00 am
TYS
- SNA
1 stop27h 50m
Multiple Airlines
Sat 4/252:39 pm
SNA
- TYS
2 stops21h 54m
Multiple Airlines
Deal found 2/23![Multiple Airlines logo]()
$292
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/84:30 pm
TYS
- SNA
1 stop8h 28m
United Airlines
Wed 4/1511:10 am
SNA
- TYS
2 stops8h 53m
United Airlines
Deal found 2/20![United Airlines logo]()
$294
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:48 pm
TYS
- SNA
1 stop7h 42m
United Airlines
Tue 4/281:21 pm
SNA
- TYS
1 stop6h 08m
United Airlines
Deal found 2/21![United Airlines logo]()
$310
This Frontier deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:28 pm
TYS
- SNA
1 stop21h 16m
Frontier
Sat 4/2512:10 pm
SNA
- TYS
1 stop24h 23m
Frontier
Deal found 2/23![Frontier logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:43 pm
TYS
- SNA
1 stop10h 13m
Multiple Airlines
Sun 4/197:56 pm
SNA
- TYS
1 stop23h 55m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:00 am
TYS
- SNA
1 stop27h 50m
Multiple Airlines
Wed 5/64:37 pm
SNA
- TYS
2 stops19h 56m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SNA
2 stops19h 22m
Multiple Airlines
Sat 5/22:39 pm
SNA
- TYS
1 stop22h 41m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$343
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:54 pm
TYS
- SNA
1 stop7h 20m
Delta
Sat 4/251:11 pm
SNA
- TYS
1 stop7h 43m
Delta
Deal found 2/19![Delta logo]()
$344
Best flights from Knoxville to Santa AnaDiscover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 23, 2026.
Discover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 23, 2026.
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:29 pm
TYS
- SNA
1 stop6h 54m
American Airlines
Tue 3/318:17 am
SNA
- TYS
1 stop6h 14m
American Airlines
Deal found 2/19![American Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:43 pm
TYS
- SNA
1 stop10h 13m
Multiple Airlines
Sun 4/197:56 pm
SNA
- TYS
1 stop23h 55m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:54 pm
TYS
- SNA
1 stop7h 20m
Delta
Sat 4/251:11 pm
SNA
- TYS
1 stop7h 43m
Delta
Deal found 2/19![Delta logo]()
$344
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:05 am
TYS
- SNA
1 stop10h 06m
United Airlines
Tue 3/316:39 pm
SNA
- TYS
2 stops12h 29m
United Airlines
Deal found 2/19![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:45 pm
TYS
- SNA
1 stop7h 50m
Southwest
Mon 5/49:10 pm
SNA
- TYS
2 stops11h 50m
Southwest
Deal found 2/20![Southwest logo]()
$429
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:49 am
TYS
- SNA
2 stops12h 59m
United Airlines
Mon 5/46:39 pm
SNA
- TYS
2 stops12h 27m
United Airlines
Deal found 2/20![United Airlines logo]()
$414
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:54 pm
TYS
- SNA
1 stop7h 20m
Delta
Mon 4/209:20 pm
SNA
- TYS
1 stop9h 02m
Delta
Deal found 2/21![Delta logo]()
$436
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:45 pm
TYS
- SNA
1 stop7h 50m
Southwest
Sun 4/199:10 pm
SNA
- TYS
2 stops11h 30m
Southwest
Deal found 2/19![Southwest logo]()
$448
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2210:49 am
TYS
- SNA
2 stops12h 58m
United Airlines
Mon 5/46:39 pm
SNA
- TYS
2 stops12h 27m
United Airlines
Deal found 2/20![United Airlines logo]()
$484
Last-minute flights from Knoxville to Santa AnaDiscover last-minute flight deals from Knoxville to Santa Ana. Data last updated February 23, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santa Ana. Data last updated February 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:13 pm
TYS
- SNA
2 stops22h 29m
Multiple Airlines
Wed 3/46:45 am
SNA
- TYS
1 stop9h 18m
Multiple Airlines
Deal found 2/23![Multiple Airlines logo]()
$434
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:54 am
TYS
- SNA
1 stop24h 56m
Multiple Airlines
Tue 3/172:53 pm
SNA
- TYS
1 stop25h 10m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$390
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:29 pm
TYS
- SNA
1 stop6h 54m
American Airlines
Tue 3/318:17 am
SNA
- TYS
1 stop6h 14m
American Airlines
Deal found 2/19![American Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:55 pm
TYS
- SNA
1 stop7h 50m
United Airlines
Tue 3/316:39 pm
SNA
- TYS
2 stops12h 29m
United Airlines
Deal found 2/20![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:25 pm
TYS
- SNA
2 stops10h 30m
Southwest
Tue 3/318:10 am
SNA
- TYS
2 stops8h 55m
Southwest
Deal found 2/20![Southwest logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:30 am
TYS
- SNA
2 stops36h 41m
Multiple Airlines
Mon 3/3010:48 am
SNA
- TYS
1 stop8h 51m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$383
One-way flights from Knoxville to Santa AnaSearch for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated February 23, 2026.
Search for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated February 23, 2026.
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/229:00 am
TYS
- SNA
1 stop7h 36m
United Airlines
Deal found 2/20![United Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SNA
1 stop21h 16m
Frontier
Deal found 2/20![Frontier logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1512:45 pm
TYS
- SNA
2 stops35h 11m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$164
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:54 pm
TYS
- SNA
1 stop6h 45m
American Airlines
Deal found 2/19![American Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:25 pm
TYS
- SNA
2 stops28h 36m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SNA
3 stops26h 12m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$196
Find flight deals from Knoxville to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $289 (American Airlines) |
One-way from | $145 (United Airlines) |
Popular in | January |
Cheapest in | May |
Average price | $413 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.
Fly from
Knoxville
Fly to
Santa Ana
Route
Depart
Return
Price
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Tue 3/24
4:29 pm-8:23 pm
1 stop6h 54m
Santa Ana J. Wayne/Orange Cnty
Tue 3/31
8:17 am-5:31 pm
1 stop6h 14m
$289
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Fri 4/17
1:43 pm-8:56 pm
1 stop10h 13m
Santa Ana J. Wayne/Orange Cnty
Sun 4/19
7:56 pm-10:51 pm
1 stop23h 55m
$317
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Thu 4/16
5:54 pm-10:14 pm
1 stop7h 20m
Santa Ana J. Wayne/Orange Cnty
Sat 4/25
1:11 pm-11:54 pm
1 stop7h 43m
$344
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Tue 3/24
7:05 am-2:11 pm
1 stop10h 06m
Santa Ana J. Wayne/Orange Cnty
Tue 3/31
6:39 pm-10:08 am
2 stops12h 29m
$384
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Sat 4/25
10:49 am-8:48 pm
2 stops12h 59m
Santa Ana J. Wayne/Orange Cnty
Mon 5/4
6:39 pm-10:06 am
2 stops12h 27m
$414
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Fri 4/24
2:45 pm-7:35 pm
1 stop7h 50m
Santa Ana J. Wayne/Orange Cnty
Mon 5/4
9:10 pm-12:00 pm
2 stops11h 50m
$429
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Thu 4/16
5:54 pm-10:14 pm
1 stop7h 20m
Santa Ana J. Wayne/Orange Cnty
Mon 4/20
9:20 pm-9:22 am
1 stop9h 02m
$436
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Fri 4/17
2:45 pm-7:35 pm
1 stop7h 50m
Santa Ana J. Wayne/Orange Cnty
Sun 4/19
9:10 pm-11:40 am
2 stops11h 30m
$448
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Wed 4/22
10:49 am-8:47 pm
2 stops12h 58m
Santa Ana J. Wayne/Orange Cnty
Mon 5/4
6:39 pm-10:06 am
2 stops12h 27m
$484
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Wed 4/22
9:00 am-1:36 pm
1 stop7h 36m
$145
Showing 1-10 of 15 results
Compare providers for flights from Knoxville to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santa Ana flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santa Ana flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
TYS-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Santa Ana
How far ahead should I book a flight from Knoxville to Santa Ana?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on February 20, 2026.
Booking 88 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Knoxville to Santa Ana?
Currently, July is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $130). Flying from Knoxville to Santa Ana in September is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated February 23, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.9
Comfort
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santa Ana?
Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Knoxville and Santa Ana flights
Browse other Knoxville and Santa Ana flight options. Last updated on February 23, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on February 23, 2026.
Popular flight searches
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Other flights to Santa Ana
Explore flights to Santa Ana departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 23, 2026.
Top 3 airlines flying from Knoxville to Santa Ana
Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$269 | Average$435 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$282 | Average$417 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$498 | FlexibilityNo cancel fee | On-time69% |