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Santa Ana

$143+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
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Cheap flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:05 am
TYS
-
SNA
1 stop8h 00m
American Airlines
Tue 3/3112:52 pm
SNA
-
TYS
1 stop7h 28m
American Airlines
Deal found 2/3$289
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:49 am
TYS
-
SNA
2 stops9h 44m
United Airlines
Tue 4/2811:10 am
SNA
-
TYS
2 stops8h 19m
United Airlines
Deal found 1/31$300
This Delta deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:54 pm
TYS
-
SNA
1 stop7h 20m
Delta
Mon 4/209:20 pm
SNA
-
TYS
1 stop9h 04m
Delta
Deal found 2/4$339
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:30 am
TYS
-
SNA
1 stop8h 09m
Delta
Thu 8/272:29 pm
SNA
-
TYS
1 stop6h 18m
Delta
Deal found 1/31$363
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:00 am
TYS
-
SNA
1 stop13h 57m
Multiple Airlines
Mon 3/231:12 pm
SNA
-
TYS
2 stops21h 58m
Multiple Airlines
Deal found 2/3$369
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:00 am
TYS
-
SNA
2 stops13h 11m
Multiple Airlines
Mon 5/117:30 am
SNA
-
TYS
1 stop12h 21m
Multiple Airlines
Deal found 1/31$375
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/174:00 pm
TYS
-
SNA
1 stop9h 04m
Delta
Wed 9/211:55 am
SNA
-
TYS
1 stop6h 51m
Delta
Deal found 1/31$381
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1512:20 pm
TYS
-
SNA
2 stops8h 45m
American Airlines
Wed 9/22:40 pm
SNA
-
TYS
1 stop6h 13m
American Airlines
Deal found 1/31$384

Find flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$289
(American Airlines)

One-way from

$143
(Trip.com)

Popular in

January

Cheapest in

May

Average price

$329
Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flights.
Search Deals
From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($63 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Knoxville

Fly to

Santa Ana

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 3/24

5:05 am-10:05 am

1 stop8h 00m

Santa Ana J. Wayne/Orange Cnty

Tue 3/31

12:52 pm-11:20 pm

1 stop7h 28m

$289

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 4/21

7:05 am-3:03 pm

2 stops10h 58m

Santa Ana J. Wayne/Orange Cnty

Tue 4/28

6:45 am-4:52 pm

1 stop7h 07m

$294

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 4/16

5:54 pm-10:14 pm

1 stop7h 20m

Santa Ana J. Wayne/Orange Cnty

Mon 4/20

9:20 pm-9:24 am

1 stop9h 04m

$339

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 3/23

1:36 pm-9:13 pm

1 stop10h 37m

Santa Ana J. Wayne/Orange Cnty

Sat 3/28

2:53 pm-9:27 pm

2 stops27h 34m

$363

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 4/9

8:00 am-10:05 am

1 stop29h 05m

$145

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 4/22

5:15 pm-9:45 pm

1 stop7h 30m

$145

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 4/8

2:55 pm-8:55 pm

1 stop9h 00m

$145

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 5/5

9:00 am-1:36 pm

1 stop7h 36m

$145

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 3/11

10:00 am-3:42 pm

1 stop8h 42m

$147

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 4/22

6:54 pm-10:45 pm

1 stop6h 51m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 11 results
1
2

Compare providers for flights from Knoxville to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana, California?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on January 30, 2026.

Booking 88 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana, California. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $142). Flying from Knoxville to Santa Ana, California in September is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated February 4, 2026.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,144 reviews

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,144 reviews
Delta
7.9
Good
8,144 reviews

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
9,236 reviews
Delta
7.9
Good
8,144 reviews

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,222 reviews
Delta
7.9
Good
8,144 reviews

Food

7.2

Entertainment

7.8

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Ana, California?

    Departing from Knoxville to Santa Ana, California will take you 8h. There are 1918 mi between Knoxville and Santa Ana, California. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to Santa Ana, California round-trip?

    Currently priced at $258, United Airlines will fly you from Knoxville to Santa Ana, California and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Delta - these airlines can fly you to your destination from $269 and $282, respectively. You may be able to fly from Knoxville to Santa Ana, California for 42% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $142). Flying from Knoxville to Santa Ana, California in September is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

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Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$258Average$479FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$269Average$433FlexibilityNo cancel feeOn-time71%
DeltaCheapest$282Average$417FlexibilityNo cancel feeOn-timeN/A

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