How long is the flight from Knoxville to Santa Ana, California?

Departing from Knoxville to Santa Ana, California will take you 7h 25m. There are 1918 mi between Knoxville and Santa Ana, California. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from Knoxville to Santa Ana, California round-trip?

Currently priced at $258, United Airlines will fly you from Knoxville to Santa Ana, California and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Delta - these airlines can fly you to your destination from $269 and $282, respectively. You may be able to fly from Knoxville to Santa Ana, California for 39% less than the average price by searching for these airlines.

In terms of precipitation, rainfall in Santa Ana, California ranges from 0.0 - 3.1 inches per month. February is typically the wettest month, when rainfall can reach 3.1 in. July is typically the driest time to visit Santa Ana, California when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santa Ana, California, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 55.4 F).

What are the most popular airlines that fly from Knoxville to Santa Ana, California?

Before booking your flight from Knoxville to Santa Ana, California check out the most popular airlines for this route: American Airlines, Delta or United Airlines.

Most accurate provider : When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Santa Ana?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

Can I find deals for business class flights from Knoxville to Santa Ana?

Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$138+ Flights from Knoxville to Santa Ana, CA

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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty are usually found in February or May, booked 88 days in advance, depart on a Saturday or Friday and return on a Saturday

Cheap flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Tue 12/304:46 pmTYS - SNA

1 stop21h 22mMultiple Airlines

Wed 12/318:04 pmSNA - TYS

2 stops22h 27mMultiple Airlines

Deal found 12/26

$567

Tue 12/304:46 pmTYS - SNA

1 stop21h 22mMultiple Airlines

Thu 1/15:39 pmSNA - TYS

2 stops40h 54mMultiple Airlines

Deal found 12/26

$661

Tue 12/304:04 pmTYS - SNA

1 stop9h 26mUnited Airlines

Wed 12/311:18 pmSNA - TYS

1 stop6h 11mUnited Airlines

Deal found 12/26

$809

Tue 12/3011:58 amTYS - SNA

2 stops11h 44mUnited Airlines

Thu 1/18:55 amSNA - TYS

2 stops12h 04mUnited Airlines

Deal found 12/26

$819

Tue 12/305:23 amTYS - SNA

2 stops9h 33mAmerican Airlines

Wed 12/316:45 amSNA - TYS

2 stops12h 13mAmerican Airlines

Deal found 12/26

$943

Best flights from Knoxville to Santa Ana
Discover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.

Thu 2/129:00 amTYS - SNA

1 stop10h 40mMultiple Airlines

Thu 2/194:37 pmSNA - TYS

1 stop27h 24mMultiple Airlines

Deal found 12/26

$309

Wed 3/115:40 amTYS - SNA

1 stop7h 25mAmerican Airlines

Mon 3/167:45 amSNA - TYS

1 stop9h 20mAmerican Airlines

Deal found 12/27

$357

Tue 2/177:05 amTYS - SNA

1 stop10h 06mUnited Airlines

Thu 2/2610:51 amSNA - TYS

1 stop6h 46mUnited Airlines

Deal found 12/27

$380

Fri 1/167:15 amTYS - SNA

2 stops35h 27mMultiple Airlines

Mon 1/196:45 amSNA - TYS

1 stop7h 05mMultiple Airlines

Deal found 12/26

$355

Tue 3/1012:24 pmTYS - SNA

2 stops9h 34mAmerican Airlines

Thu 3/193:24 pmSNA - TYS

1 stop16h 21mAmerican Airlines

Deal found 12/27

$411

Mon 1/58:00 amTYS - SNA

1 stop14h 21mMultiple Airlines

Mon 1/126:45 amSNA - TYS

1 stop7h 05mMultiple Airlines

Deal found 12/27

$384

Thu 1/1510:00 amTYS - SNA

1 stop7h 19mMultiple Airlines

Sun 1/185:31 pmSNA - TYS

1 stop20h 19mMultiple Airlines

Deal found 12/26

$388

Thu 1/88:30 amTYS - SNA

2 stops33h 49mMultiple Airlines

Mon 1/126:45 amSNA - TYS

1 stop7h 05mMultiple Airlines

Deal found 12/27

$401

Tue 3/109:00 amTYS - SNA

1 stop26h 55mMultiple Airlines

Thu 3/198:20 pmSNA - TYS

1 stop23h 19mMultiple Airlines

Deal found 12/27

$403

Last-minute flights from Knoxville to Santa Ana
Discover last-minute flight deals from Knoxville to Santa Ana. Data last updated December 28, 2025 and is based on user searches.

Thu 1/17:00 amTYS - SNA

1 stop10h 07mUnited Airlines

Fri 1/98:00 amSNA - TYS

1 stop7h 05mUnited Airlines

Deal found 12/26

$489

Mon 1/58:00 amTYS - SNA

1 stop14h 21mMultiple Airlines

Sun 1/114:16 pmSNA - TYS

1 stop21h 34mMultiple Airlines

Deal found 12/27

$344

Wed 1/76:00 amTYS - SNA

1 stop7h 03mAmerican Airlines

Thu 1/1511:42 amSNA - TYS

1 stop7h 27mAmerican Airlines

Deal found 12/25

$470

Fri 1/96:09 pmTYS - SNA

1 stop7h 06mDelta

Sat 1/108:00 amSNA - TYS

1 stop7h 58mDelta

Deal found 12/25

$493

Sat 1/102:37 pmTYS - SNA

1 stop8h 37mDelta

Tue 1/136:45 amSNA - TYS

1 stop5h 34mDelta

Deal found 12/25

$429

Thu 1/1510:00 amTYS - SNA

1 stop7h 19mMultiple Airlines

Sun 1/185:31 pmSNA - TYS

1 stop20h 19mMultiple Airlines

Deal found 12/26

$388

Thu 1/156:45 amTYS - SNA

1 stop8h 06mUnited Airlines

Sun 1/1811:05 amSNA - TYS

2 stops9h 39mUnited Airlines

Deal found 12/26

$468

Fri 1/167:15 amTYS - SNA

2 stops35h 27mMultiple Airlines

Mon 1/196:45 amSNA - TYS

1 stop7h 05mMultiple Airlines

Deal found 12/26

$355

Mon 1/264:55 pmTYS - SNA

1 stop7h 47mUnited Airlines

Thu 1/2910:51 amSNA - TYS

1 stop7h 01mUnited Airlines

Deal found 12/26

$455

One-way flights from Knoxville to Santa Ana
Search for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated December 28, 2025.

Sun 2/228:30 amTYS - SNA

1 stop13h 05mMultiple Airlines

Deal found 12/27

$138

Fri 3/64:20 pmTYS - SNA

1 stop21h 27mFrontier

Deal found 12/27

$175

Fri 3/64:56 pmTYS - SNA

1 stop7h 36mAmerican Airlines

Deal found 12/27

$219

Fri 3/64:20 pmTYS - SNA

3 stops31h 37mMultiple Airlines

Deal found 12/27

$232

Fri 3/63:45 pmTYS - SNA

2 stops8h 25mSouthwest

Deal found 12/27

$244

Sat 2/219:40 amTYS - SNA

2 stops14h 47mUnited Airlines

Deal found 12/25

$256

Sat 2/215:35 amTYS - SNA

1 stop9h 14mDelta

Deal found 12/25

$279

Mon 1/196:45 amTYS - SNA

1 stop8h 06mUnited Airlines

Deal found 12/25

$285

Find flight deals from Knoxville to Santa Ana

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$309 (Kiwi.com)
One-way from	$138 (Kiwi.com)
Popular in	November
Cheapest in	February
Average price	$604

Provider with most accurate pricing for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flight deals.

Search Deals

Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santa Ana J. Wayne/Orange Cnty flights.

Search Deals

From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty

Search Deals

One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty

Search Deals

Highest demand for flights based on searches. 25% potential increase in price ($149 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 2/12

9:00 am-4:40 pm

1 stop10h 40m

Santa Ana J. Wayne/Orange Cnty

Thu 2/19

4:37 pm-11:01 pm

1 stop27h 24m

$309

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 1/16

7:15 am-3:42 pm

2 stops35h 27m

Santa Ana J. Wayne/Orange Cnty

Mon 1/19

6:45 am-4:50 pm

1 stop7h 05m

$355

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 3/11

5:40 am-10:05 am

1 stop7h 25m

Santa Ana J. Wayne/Orange Cnty

Mon 3/16

7:45 am-8:05 pm

1 stop9h 20m

$357

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 2/17

7:05 am-2:11 pm

1 stop10h 06m

Santa Ana J. Wayne/Orange Cnty

Thu 2/26

10:51 am-8:37 pm

1 stop6h 46m

$380

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 1/5

8:00 am-7:21 pm

1 stop14h 21m

Santa Ana J. Wayne/Orange Cnty

Mon 1/12

6:45 am-4:50 pm

1 stop7h 05m

$384

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 1/15

10:00 am-2:19 pm

1 stop7h 19m

Santa Ana J. Wayne/Orange Cnty

Sun 1/18

5:31 pm-4:50 pm

1 stop20h 19m

$388

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 1/8

8:30 am-3:19 pm

2 stops33h 49m

Santa Ana J. Wayne/Orange Cnty

Mon 1/12

6:45 am-4:50 pm

1 stop7h 05m

$401

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 3/10

9:00 am-8:55 am

1 stop26h 55m

Santa Ana J. Wayne/Orange Cnty

Thu 3/19

8:20 pm-10:39 pm

1 stop23h 19m

$403

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 3/10

12:24 pm-6:58 pm

2 stops9h 34m

Santa Ana J. Wayne/Orange Cnty

Thu 3/19

3:24 pm-10:45 am

1 stop16h 21m

$411

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Sun 2/22

8:30 am-6:35 pm

1 stop13h 05m

$138

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/27

Showing 1-10 of 18 results

Compare providers for flights from Knoxville to Santa Ana

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana, California?

Booking 88 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana, California. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $142). Flying from Knoxville to Santa Ana, California in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SNA?

When flying from Knoxville to Santa Ana, California, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 41% versus a flight in the afternoon.

Reviews of airlines servicing Santa Ana

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

7.9

Good

8,019 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

9,113 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

11,072 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

How long is the flight from Knoxville to Santa Ana, California?
Departing from Knoxville to Santa Ana, California will take you 7h 25m. There are 1918 mi between Knoxville and Santa Ana, California. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from Knoxville to Santa Ana, California round-trip?
Currently priced at $258, United Airlines will fly you from Knoxville to Santa Ana, California and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Delta - these airlines can fly you to your destination from $269 and $282, respectively. You may be able to fly from Knoxville to Santa Ana, California for 39% less than the average price by searching for these airlines.
Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?
Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Santa Ana?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.
Can I find deals for business class flights from Knoxville to Santa Ana?
Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Santa Ana, California?
Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $142). Flying from Knoxville to Santa Ana, California in June is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Tustin

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Knoxville to Santa Ana

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$258	Average$479	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$269	Average$428	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$282	Average$388	FlexibilityNo cancel fee	On-timeN/A

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$138+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/22. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to Santa Ana with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty are usually found in February or May, booked 88 days in advance, depart on a Saturday or Friday and return on a Saturday

Cheap flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa AnaExplore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Find flight deals from Knoxville to Santa Ana

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Compare providers for flights from Knoxville to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in December.

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana, California?

What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

What is the cheapest time of day to fly from TYS to SNA?

Reviews of airlines servicing Santa Ana

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Knoxville to Santa Ana, California?

What are the cheapest airlines flying from Knoxville to Santa Ana, California round-trip?

Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

How can I find direct flights from Knoxville to Santa Ana?

Can I find deals for business class flights from Knoxville to Santa Ana?

What is the cheapest month to book a flight from Knoxville to Santa Ana, California?

Traveling to a place near Santa Ana?

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Alternative routes for Knoxville to Santa Ana

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Top 3 airlines flying from Knoxville to Santa Ana

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Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.