$130+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
May 10 — May 171
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santa Ana
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Best
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Cheapest flights from Knoxville to Santa AnaExplore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.
This Trip.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SNA
1 stop21h 16m
Frontier
Sat 4/2512:10 pm
SNA
- TYS
1 stop24h 23m
Frontier
Deal found 4/8![Frontier logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:43 pm
TYS
- SNA
1 stop11h 02m
Multiple Airlines
Fri 5/13:23 pm
SNA
- TYS
2 stops23h 40m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$289
This Trip.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SNA
1 stop21h 16m
Multiple Airlines
Sun 4/267:56 pm
SNA
- TYS
1 stop23h 55m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:59 pm
TYS
- SNA
2 stops34h 46m
Multiple Airlines
Fri 4/246:45 am
SNA
- TYS
1 stop13h 06m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/127:00 am
TYS
- SNA
1 stop28h 09m
Multiple Airlines
Thu 7/161:50 pm
SNA
- TYS
1 stop6h 06m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:55 pm
TYS
- SNA
1 stop7h 40m
United Airlines
Tue 5/1212:13 pm
SNA
- TYS
1 stop8h 31m
United Airlines
Deal found 4/7![United Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/131:43 pm
TYS
- SNA
1 stop8h 57m
Multiple Airlines
Fri 4/176:45 am
SNA
- TYS
1 stop13h 06m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$350
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:47 pm
TYS
- SNA
1 stop27h 08m
Multiple Airlines
Thu 7/161:50 pm
SNA
- TYS
1 stop6h 06m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$353
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:54 pm
TYS
- SNA
1 stop6h 51m
American Airlines
Tue 5/52:42 pm
SNA
- TYS
1 stop6h 14m
American Airlines
Deal found 4/6![American Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:47 pm
TYS
- SNA
1 stop27h 08m
Multiple Airlines
Mon 7/138:55 am
SNA
- TYS
1 stop7h 42m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$364
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:05 am
TYS
- SNA
2 stops9h 50m
Southwest
Sat 5/167:15 am
SNA
- TYS
2 stops9h 20m
Southwest
Deal found 4/10![Southwest logo]()
$369
Best flights from Knoxville to Santa AnaDiscover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 10, 2026.
Discover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 10, 2026.
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/52:55 pm
TYS
- SNA
2 stops9h 50m
Southwest
Tue 5/127:20 am
SNA
- TYS
2 stops9h 20m
Southwest
Deal found 4/5![Southwest logo]()
$396
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:56 pm
TYS
- SNA
1 stop7h 54m
United Airlines
Mon 9/1412:04 pm
SNA
- TYS
1 stop6h 26m
United Airlines
Deal found 4/5![United Airlines logo]()
$457
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:45 pm
TYS
- SNA
1 stop7h 50m
Southwest
Tue 5/56:45 am
SNA
- TYS
2 stops9h 55m
Southwest
Deal found 4/6![Southwest logo]()
$399
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:00 am
TYS
- SNA
2 stops13h 33m
United Airlines
Sat 5/98:45 am
SNA
- TYS
2 stops9h 00m
United Airlines
Deal found 4/9![United Airlines logo]()
$460
This Southwest deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:10 am
TYS
- SNA
2 stops10h 35m
Southwest
Sun 6/287:50 pm
SNA
- TYS
2 stops13h 10m
Southwest
Deal found 4/9![Southwest logo]()
$429
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:00 am
TYS
- SNA
2 stops10h 22m
United Airlines
Tue 5/128:45 am
SNA
- TYS
2 stops11h 59m
United Airlines
Deal found 4/9![United Airlines logo]()
$472
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:50 pm
TYS
- SNA
1 stop8h 05m
Southwest
Mon 9/148:50 pm
SNA
- TYS
2 stops12h 15m
Southwest
Deal found 4/5![Southwest logo]()
$468
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:00 am
TYS
- SNA
2 stops10h 22m
United Airlines
Tue 5/128:45 am
SNA
- TYS
2 stops11h 59m
United Airlines
Deal found 4/9![United Airlines logo]()
$472
This Southwest deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:30 pm
TYS
- SNA
2 stops10h 15m
Southwest
Fri 10/96:45 am
SNA
- TYS
2 stops8h 55m
Southwest
Deal found 4/9![Southwest logo]()
$501
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:00 am
TYS
- SNA
2 stops10h 22m
United Airlines
Mon 5/117:45 pm
SNA
- TYS
2 stops11h 21m
United Airlines
Deal found 4/5![United Airlines logo]()
$525
Last-minute flights from Knoxville to Santa AnaDiscover last-minute flight deals from Knoxville to Santa Ana. Data last updated April 10, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santa Ana. Data last updated April 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/131:43 pm
TYS
- SNA
1 stop8h 57m
Multiple Airlines
Fri 4/176:45 am
SNA
- TYS
1 stop13h 06m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$350
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:59 pm
TYS
- SNA
2 stops34h 46m
Multiple Airlines
Fri 4/246:45 am
SNA
- TYS
1 stop13h 06m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$314
This Trip.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SNA
1 stop21h 16m
Frontier
Sat 4/2512:10 pm
SNA
- TYS
1 stop24h 23m
Frontier
Deal found 4/8![Frontier logo]()
$249
This Trip.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SNA
1 stop21h 16m
Multiple Airlines
Sun 4/267:56 pm
SNA
- TYS
1 stop23h 55m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/271:43 pm
TYS
- SNA
1 stop11h 02m
Multiple Airlines
Fri 5/13:23 pm
SNA
- TYS
2 stops23h 40m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:54 pm
TYS
- SNA
1 stop6h 51m
American Airlines
Tue 5/52:42 pm
SNA
- TYS
1 stop6h 14m
American Airlines
Deal found 4/6![American Airlines logo]()
$361
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:35 am
TYS
- SNA
2 stops8h 20m
Southwest
Tue 5/56:45 am
SNA
- TYS
2 stops9h 55m
Southwest
Deal found 4/6![Southwest logo]()
$371
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:55 pm
TYS
- SNA
1 stop7h 40m
United Airlines
Tue 5/1212:13 pm
SNA
- TYS
1 stop8h 31m
United Airlines
Deal found 4/7![United Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:05 am
TYS
- SNA
2 stops9h 50m
Southwest
Sat 5/167:15 am
SNA
- TYS
2 stops9h 20m
Southwest
Deal found 4/10![Southwest logo]()
$369
One-way flights from Knoxville to Santa AnaSearch for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated April 10, 2026.
Search for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated April 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/151:43 pm
TYS
- SNA
1 stop11h 25m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$130
This Trip.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:28 pm
TYS
- SNA
1 stop21h 16m
Frontier
Deal found 4/8![Frontier logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:32 pm
TYS
- SNA
1 stop15h 37m
Frontier
Deal found 4/8![Frontier logo]()
$138
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:36 am
TYS
- SNA
1 stop7h 04m
American Airlines
Deal found 4/7![American Airlines logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:49 pm
TYS
- SNA
1 stop29h 34m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$176
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:15 am
TYS
- SNA
2 stops10h 41m
United Airlines
Deal found 4/7![United Airlines logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:15 pm
TYS
- SNA
2 stops29h 23m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/283:46 pm
TYS
- SNA
3 stops29h 02m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:15 pm
TYS
- SNA
3 stops34h 50m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$225
Find flight deals from Knoxville to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $249 (Trip.com) |
One-way from | $130 (Kiwi.com) |
Popular in | January |
Cheapest in | May |
Average price | $470 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Tue 5/5
2:55 pm-9:45 pm
2 stops9h 50m
Santa Ana J. Wayne/Orange Cnty
Tue 5/12
7:20 am-7:40 pm
2 stops9h 20m
$396
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Thu 4/30
2:45 pm-7:35 pm
1 stop7h 50m
Santa Ana J. Wayne/Orange Cnty
Tue 5/5
6:45 am-7:40 pm
2 stops9h 55m
$399
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Wed 6/24
7:10 am-2:45 pm
2 stops10h 35m
Santa Ana J. Wayne/Orange Cnty
Sun 6/28
7:50 pm-12:00 pm
2 stops13h 10m
$429
Quickest round-trip
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Thu 9/10
4:56 pm-9:50 pm
1 stop7h 54m
Santa Ana J. Wayne/Orange Cnty
Mon 9/14
12:04 pm-9:30 pm
1 stop6h 26m
$457
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Tue 5/5
7:00 am-5:33 pm
2 stops13h 33m
Santa Ana J. Wayne/Orange Cnty
Sat 5/9
8:45 am-8:45 pm
2 stops9h 00m
$460
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Thu 9/10
4:50 pm-9:55 pm
1 stop8h 05m
Santa Ana J. Wayne/Orange Cnty
Mon 9/14
8:50 pm-12:05 pm
2 stops12h 15m
$468
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Thu 5/7
7:00 am-2:22 pm
2 stops10h 22m
Santa Ana J. Wayne/Orange Cnty
Tue 5/12
8:45 am-11:44 pm
2 stops11h 59m
$472
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Sat 5/2
7:00 am-2:22 pm
2 stops10h 22m
Santa Ana J. Wayne/Orange Cnty
Tue 5/12
8:45 am-11:44 pm
2 stops11h 59m
$472
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Sat 10/3
1:30 pm-8:45 pm
2 stops10h 15m
Santa Ana J. Wayne/Orange Cnty
Fri 10/9
6:45 am-6:40 pm
2 stops8h 55m
$501
KnoxvilleSanta Ana
TYS - SNA
TYSSNA
Knoxville McGhee Tyson
Fri 5/8
7:00 am-2:22 pm
2 stops10h 22m
Santa Ana J. Wayne/Orange Cnty
Mon 5/11
7:45 pm-10:06 am
2 stops11h 21m
$525
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
TYS-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Santa Ana
How far ahead should I book a flight from Knoxville to Santa Ana, California?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on April 3, 2026.
Booking 77 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana, California. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Knoxville to Santa Ana, California?
Currently, July is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $88). Flying from Knoxville to Santa Ana, California in September is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Santa Ana, California?
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated April 10, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Knoxville and Santa Ana flights
Browse other Knoxville and Santa Ana flight options. Last updated on April 10, 2026.
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Top 3 airlines flying from Knoxville to Santa Ana
Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$282 | Average$388 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$498 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$288 | Average$470 | FlexibilityNo cancel fee | On-time71% |