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$132+ Cheap flights from Knoxville to Santa Ana (TYS - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty are usually found in February or May, booked 90 days in advance, depart on a Saturday or Friday and return on a Saturday

Cheap flight deals from Knoxville to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$289
(American Airlines)

One-way from

$132
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$371
From Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
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One-way flight from Knoxville McGhee Tyson to Santa Ana J. Wayne/Orange Cnty
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Highest demand for flights based on searches. 10% potential increase in price ($46 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Santa Ana

Cheapest flights from Knoxville to Santa Ana
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/312:02 pmTYS - SNA
1 stop8h 35mAmerican Airlines
Tue 11/411:42 amSNA - TYS
1 stop6h 42mAmerican Airlines
Deal found 9/15$289
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/412:46 pmTYS - SNA
2 stops10h 17mAmerican Airlines
Tue 11/1112:30 pmSNA - TYS
2 stops8h 38mAmerican Airlines
Deal found 9/14$299
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:40 amTYS - SNA
2 stops10h 35mDelta
Tue 11/47:00 amSNA - TYS
2 stops12h 55mDelta
Deal found 9/15$313
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/238:17 pmTYS - SNA
1 stop17h 59mFrontier
Sun 10/265:52 pmSNA - TYS
2 stops22h 40mFrontier
Deal found 9/16$317
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1310:12 pmTYS - SNA
1 stop24h 02mMultiple Airlines
Thu 10/168:09 pmSNA - TYS
1 stop14h 14mMultiple Airlines
Deal found 9/14$350
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:00 amTYS - SNA
1 stop6h 45mAmerican Airlines
Tue 10/2112:44 pmSNA - TYS
1 stop8h 39mAmerican Airlines
Deal found 9/16$372
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/38:15 amTYS - SNA
2 stops15h 44mMultiple Airlines
Sun 12/710:42 amSNA - TYS
1 stop26h 10mMultiple Airlines
Deal found 9/15$374
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/144:40 pmTYS - SNA
1 stop8h 26mUnited Airlines
Tue 10/2111:32 amSNA - TYS
2 stops9h 11mUnited Airlines
Deal found 9/16$376
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/298:30 amTYS - SNA
1 stop16h 35mMultiple Airlines
Fri 10/36:45 amSNA - TYS
3 stops22h 05mMultiple Airlines
Deal found 9/15$377
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/237:00 amTYS - SNA
1 stop7h 16mMultiple Airlines
Sun 10/265:52 pmSNA - TYS
1 stop21h 27mMultiple Airlines
Deal found 9/16$390

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.

Fly from

Knoxville

Fly to

Santa Ana

Route

Depart

Return

Price

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 10/31

6:00 am-9:36 am

1 stop6h 36m

Santa Ana J. Wayne/Orange Cnty

Tue 11/4

3:03 pm-12:08 am

1 stop6h 05m

$289

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 11/4

12:46 pm-8:03 pm

2 stops10h 17m

Santa Ana J. Wayne/Orange Cnty

Tue 11/11

12:30 pm-12:08 am

2 stops8h 38m

$299

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 10/31

6:40 am-2:15 pm

2 stops10h 35m

Santa Ana J. Wayne/Orange Cnty

Tue 11/4

8:00 am-11:22 pm

2 stops12h 22m

$313

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Mon 10/13

10:12 pm-7:14 pm

1 stop24h 02m

Santa Ana J. Wayne/Orange Cnty

Thu 10/16

8:09 pm-1:23 pm

1 stop14h 14m

$350

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 10/14

6:00 am-9:45 am

1 stop6h 45m

Santa Ana J. Wayne/Orange Cnty

Tue 10/21

12:44 pm-12:23 am

1 stop8h 39m

$372

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Tue 10/14

4:40 pm-10:06 pm

1 stop8h 26m

Santa Ana J. Wayne/Orange Cnty

Tue 10/21

11:32 am-11:43 pm

2 stops9h 11m

$376

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 10/23

7:00 am-11:16 am

1 stop7h 16m

Santa Ana J. Wayne/Orange Cnty

Sun 10/26

5:52 pm-6:19 pm

1 stop21h 27m

$390

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Wed 12/3

5:24 am-9:47 am

1 stop7h 23m

Santa Ana J. Wayne/Orange Cnty

Sun 12/7

8:51 am-9:38 pm

1 stop9h 47m

$413

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Thu 1/1

12:18 pm-5:58 pm

1 stop8h 40m

Santa Ana J. Wayne/Orange Cnty

Tue 1/6

10:46 am-10:08 pm

1 stop8h 22m

$424

KnoxvilleSanta Ana

TYS - SNA

TYSSNA

Knoxville McGhee Tyson

Fri 1/9

5:43 am-10:23 am

1 stop7h 40m

Santa Ana J. Wayne/Orange Cnty

Thu 1/15

6:45 am-3:23 pm

1 stop5h 38m

$437

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 18 results
1
2

Best time to book a flight from Knoxville to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santa Ana

How far ahead should I book a flight from Knoxville to Santa Ana?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Santa Ana. Price data was last updated on September 12, 2025.

Booking 88 days in advance of your planned departure date is, on average, the best time to get cheap flights from Knoxville to Santa Ana. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Knoxville to Santa Ana?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $298). Flying from Knoxville to Santa Ana in March is currently the most expensive (average of $375). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SNA?

Find hourly flight availability from Knoxville to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from Knoxville to Santa Ana, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 19% versus a flight in the afternoon.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated September 17, 2025.
Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Santa Ana?

    Airlines like American Airlines and Delta fly from Knoxville to Santa Ana in about 6h 36m. The time it takes to get you to your destination can typically vary by up to 3h 59m. There are 1918 mi between Knoxville and Santa Ana. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Knoxville to Santa Ana round-trip?

    Flying on American Airlines is currently your cheapest option to Santa Ana, with prices starting at $255. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $258 and $282, respectively. You may be able to fly from Knoxville to Santa Ana for 36% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santa Ana.

  • Can I find deals for business class flights from Knoxville to Santa Ana?

    Yes. Cheapflights offers flight deals from Knoxville to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santa Ana?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Santa Ana (average of $298). Flying from Knoxville to Santa Ana in March is currently the most expensive (average of $375). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

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Top 3 airlines flying from Knoxville to Santa Ana

Discover the top 3 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$255Average$416FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$258Average$535FlexibilityNo cancel feeOn-time69%
DeltaCheapest$282Average$390FlexibilityNo cancel feeOn-timeN/A

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