$156+ Cheap flights from Knoxville to Santa Ana, CA (TYS - SNA)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/29. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SNA
Oct 5 — Oct 121
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santa Ana
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Best
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Cheapest flights from Knoxville to Santa AnaExplore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
Explore the most affordable flight options available from Knoxville to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop6h 45m
Tue 9/2912:14 pm -
1 stop8h 08m
Deal found 9/1![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:42 pm -
1 stop20h 21m
Mon 11/27:30 am -
1 stop10h 22m
Deal found 9/2![Multiple Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:20 pm -
1 stop8h 25m
Tue 11/37:00 am -
2 stops9h 45m
Deal found 9/1![Southwest logo]()
$368
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:30 pm -
1 stop7h 25m
Mon 10/2610:45 am -
2 stops9h 00m
Deal found 9/1![Southwest logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:54 pm -
1 stop20h 09m
Sun 10/112:53 pm -
1 stop21h 45m
Deal found 9/1![Multiple Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:30 am -
1 stop10h 05m
Tue 11/2412:10 pm -
1 stop8h 22m
Deal found 9/1![American Airlines logo]()
$415
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:25 pm -
1 stop6h 40m
Sun 10/259:35 am -
2 stops10h 10m
Deal found 9/1![Southwest logo]()
$433
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:53 pm -
1 stop8h 09m
Wed 10/2111:29 am -
1 stop7h 45m
Deal found 9/3![United Airlines logo]()
$434
Best flights from Knoxville to Santa AnaDiscover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
Discover carefully curated flight deals from Knoxville to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:30 pm -
1 stop7h 25m
Mon 10/2610:45 am -
2 stops9h 00m
Deal found 9/1![Southwest logo]()
$381
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:00 am -
1 stop8h 59m
Wed 11/41:09 pm -
1 stop6h 23m
Deal found 9/3![United Airlines logo]()
$463
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
2 stops10h 57m
Tue 9/297:30 am -
2 stops11h 44m
Deal found 9/1![United Airlines logo]()
$473
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:05 am -
2 stops10h 40m
Tue 11/2410:25 am -
2 stops9h 10m
Deal found 9/1![Southwest logo]()
$485
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:15 am -
1 stop6h 47m
Wed 10/216:36 pm -
2 stops13h 01m
Deal found 9/3![United Airlines logo]()
$583
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:55 pm -
2 stops8h 20m
Sat 9/196:45 am -
2 stops8h 00m
Deal found 8/31![Southwest logo]()
$597
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 pm -
1 stop7h 25m
Sat 9/1911:10 am -
1 stop8h 34m
Deal found 8/31![United Airlines logo]()
$587
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:50 pm -
2 stops8h 20m
Fri 9/188:45 pm -
2 stops12h 10m
Deal found 8/31![Southwest logo]()
$603
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:00 am -
2 stops9h 35m
Sun 9/208:45 pm -
2 stops13h 40m
Deal found 8/31![Southwest logo]()
$603
Last-minute flights from Knoxville to Santa AnaDiscover last-minute flight deals from Knoxville to Santa Ana. Data last updated September 5, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santa Ana. Data last updated September 5, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop6h 45m
Tue 9/2912:14 pm -
1 stop8h 08m
Deal found 9/1![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:54 pm -
1 stop20h 09m
Sun 10/112:53 pm -
1 stop21h 45m
Deal found 9/1![Multiple Airlines logo]()
$412
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:30 pm -
1 stop7h 25m
Tue 10/206:45 am -
1 stop5h 55m
Deal found 9/3![Southwest logo]()
$435
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:53 pm -
1 stop8h 09m
Wed 10/2111:29 am -
1 stop7h 45m
Deal found 9/3![United Airlines logo]()
$434
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:20 pm -
1 stop8h 25m
Tue 11/37:00 am -
2 stops9h 45m
Deal found 9/1![Southwest logo]()
$368
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:30 pm -
1 stop7h 25m
Mon 10/2610:45 am -
2 stops9h 00m
Deal found 9/1![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:25 pm -
1 stop6h 40m
Sun 10/259:35 am -
2 stops10h 10m
Deal found 9/1![Southwest logo]()
$433
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:42 pm -
1 stop20h 21m
Mon 11/27:30 am -
1 stop10h 22m
Deal found 9/2![Multiple Airlines logo]()
$367
One-way flights from Knoxville to Santa AnaSearch for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
Search for one-way flight options from Knoxville to Santa Ana. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:30 am -
1 stop7h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$156
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:50 pm -
1 stop6h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![United Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:54 pm -
1 stop20h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$197
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/234:40 pm -
1 stop8h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Delta logo]()
$215
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:30 am -
1 stop7h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$220
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:05 am -
2 stops8h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Southwest logo]()
$225
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:10 pm -
1 stop10h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![United Airlines logo]()
$232
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:05 pm -
1 stop7h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![United Airlines logo]()
$270
Find flight deals from Knoxville to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $363 (American Airlines) |
One-way from | $156 (Kiwi.com) |
Popular in | January |
Cheapest in | May |
Average price | $496 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
Use the filters below to find and compare flights from Knoxville to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Wed 9/9
4:50 pm-8:44 pm
1 stop6h 54m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$182
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Sat 9/26
10:42 am-8:51 pm
2 stops13h 09m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$187
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Wed 9/23
4:40 pm-10:04 pm
1 stop8h 24m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$215
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Mon 11/23
7:05 am-12:15 pm
2 stops8h 10m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$225
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Sat 9/12
1:10 pm-8:24 pm
1 stop10h 14m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$232
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Mon 11/23
5:05 pm-10:00 pm
1 stop7h 55m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$270
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Thu 9/17
7:00 am-3:48 pm
2 stops35h 48m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$275
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Sun 11/22
9:00 am-2:59 pm
1 stop8h 59m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$284
Quickest round-trip
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Fri 9/18
6:13 pm-10:04 pm
1 stop6h 51m
Santa Ana J. Wayne/Orange Cnty
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$294
KnoxvilleSanta Ana
TYS Knoxville McGhee Tyson - SNA Santa Ana J. Wayne/Orange Cnty
TYSSNA
Knoxville McGhee Tyson
Thu 10/22
5:30 pm-9:55 pm
1 stop7h 25m
Santa Ana J. Wayne/Orange Cnty
Mon 10/26
10:45 am-10:45 pm
2 stops9h 00m
$381
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santa Ana in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santa Ana, California flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Knoxville with our price prediction graph.
TYS-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Santa Ana
What is the cheapest month to book a flight from Knoxville to Santa Ana, California?
Currently, May is the cheapest month in which you can book a flight from Knoxville to Santa Ana, California (average of $425). Flying from Knoxville to Santa Ana, California in January is currently the most expensive (average of $722). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Santa Ana, California?
Airfare is below average for this route at the moment.
Knoxville to Santa Ana, California flights typically cost between $393 and $616 in September.The cheapest round-trip price found within the last 5 days was $363 on American Airlines (Sep 22-Sep 29).
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated September 5, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Knoxville to Santa Ana by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Crew
8.6
Food
7.0
Comfort
8.0
Boarding
8.1
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santa Ana?
Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Knoxville and Santa Ana flights
Browse other Knoxville and Santa Ana flight options. Last updated on September 5, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santa Ana
Explore flights to Santa Ana departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 5, 2026.
Top 4 airlines flying from Knoxville to Santa Ana
Discover the top 4 airlines that operate flights from Knoxville to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$428 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$498 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$338 | Average$589 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$378 | Average$593 | FlexibilityNo cancel fee | On-time63% |