$239+ Cheap flights from Roanoke to San Francisco (ROA - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/30. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — SFO
Oct 14 — Oct 211
Round-trip
1 adult, Economy
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Find cheap flights from Roanoke to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Roanoke to San Francisco
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Cheapest flights from Roanoke to San FranciscoExplore the most affordable flight options available from Roanoke to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
Explore the most affordable flight options available from Roanoke to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:51 pm -
1 stop9h 05m
Tue 11/310:45 pm -
1 stop7h 41m
Deal found 9/9![United Airlines logo]()
$373
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:38 pm -
1 stop8h 18m
Tue 10/139:25 pm -
1 stop10h 07m
Deal found 9/10![Delta logo]()
$376
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:32 pm -
1 stop8h 25m
Mon 10/59:55 pm -
1 stop9h 37m
Deal found 9/10![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:06 pm -
1 stop10h 53m
Sun 10/1111:59 pm -
1 stop10h 49m
Deal found 9/10![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:07 am -
1 stop10h 20m
Tue 12/18:30 am -
1 stop9h 01m
Deal found 9/11![American Airlines logo]()
$393
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/153:38 pm -
1 stop8h 50m
Mon 1/189:30 pm -
1 stop10h 04m
Deal found 9/12![Delta logo]()
$396
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:49 pm -
1 stop10h 41m
Mon 10/1211:59 pm -
1 stop10h 49m
Deal found 9/9![American Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:46 pm -
1 stop10h 11m
Mon 10/59:55 pm -
1 stop9h 37m
Deal found 9/10![Delta logo]()
$409
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:38 pm -
1 stop8h 18m
Wed 10/2810:35 am -
2 stops10h 52m
Deal found 9/10![Delta logo]()
$417
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:32 pm -
1 stop7h 26m
Wed 10/72:00 pm -
1 stop7h 27m
Deal found 9/10![Delta logo]()
$419
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:32 pm -
1 stop8h 25m
Wed 10/72:40 pm -
2 stops16h 52m
Deal found 9/10![Delta logo]()
$427
Best flights from Roanoke to San FranciscoDiscover carefully curated flight deals from Roanoke to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
Discover carefully curated flight deals from Roanoke to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:05 pm -
1 stop7h 54m
Sun 10/1110:42 pm -
1 stop8h 15m
Deal found 9/9![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:51 pm -
1 stop9h 39m
Mon 9/2811:30 pm -
1 stop7h 27m
Deal found 9/10![United Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:05 pm -
1 stop7h 54m
Mon 10/1910:42 pm -
1 stop8h 15m
Deal found 9/12![United Airlines logo]()
$526
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:51 pm -
1 stop9h 39m
Mon 10/1210:42 pm -
1 stop8h 15m
Deal found 9/10![United Airlines logo]()
$529
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/53:05 pm -
1 stop8h 34m
Wed 12/94:25 pm -
2 stops14h 02m
Deal found 9/13![United Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:49 am -
2 stops15h 43m
Mon 10/1210:42 pm -
1 stop8h 15m
Deal found 9/10![United Airlines logo]()
$647
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:51 pm -
1 stop9h 39m
Sat 9/196:00 am -
1 stop8h 09m
Deal found 9/11![United Airlines logo]()
$659
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/88:05 pm -
1 stop7h 50m
Tue 10/1311:30 pm -
1 stop7h 27m
Deal found 9/10![United Airlines logo]()
$675
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/268:00 pm -
1 stop8h 29m
Fri 10/3010:49 pm -
2 stops19h 12m
Deal found 9/12![United Airlines logo]()
$678
Last-minute flights from Roanoke to San FranciscoDiscover last-minute flight deals from Roanoke to San Francisco. Data last updated September 14, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to San Francisco. Data last updated September 14, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:32 pm -
1 stop7h 26m
Wed 10/72:00 pm -
1 stop7h 27m
Deal found 9/10![Delta logo]()
$419
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:32 pm -
1 stop8h 25m
Mon 10/59:55 pm -
1 stop9h 37m
Deal found 9/10![Delta logo]()
$379
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:46 pm -
1 stop10h 11m
Mon 10/59:55 pm -
1 stop9h 37m
Deal found 9/10![Delta logo]()
$409
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:38 pm -
1 stop8h 18m
Tue 10/139:25 pm -
1 stop10h 07m
Deal found 9/10![Delta logo]()
$376
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:06 pm -
1 stop10h 53m
Sun 10/1111:59 pm -
1 stop10h 49m
Deal found 9/10![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:49 pm -
1 stop10h 41m
Mon 10/1211:59 pm -
1 stop10h 49m
Deal found 9/9![American Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/231:03 pm -
1 stop10h 21m
Wed 10/285:00 am -
1 stop9h 45m
Deal found 9/13![American Airlines logo]()
$396
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:38 pm -
1 stop8h 18m
Wed 10/2810:35 am -
2 stops10h 52m
Deal found 9/10![Delta logo]()
$417
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:51 pm -
1 stop9h 05m
Tue 11/310:45 pm -
1 stop7h 41m
Deal found 9/9![United Airlines logo]()
$373
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:07 am -
1 stop10h 20m
Tue 12/18:30 am -
1 stop9h 01m
Deal found 9/11![American Airlines logo]()
$393
One-way flights from Roanoke to San FranciscoSearch for one-way flight options from Roanoke to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
Search for one-way flight options from Roanoke to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/309:24 pm -
3 stops42h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/154:12 pm -
3 stops49h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2111:46 am -
2 stops31h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/228:32 pm -
2 stops31h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1211:08 am -
2 stops34h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$338
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:27 pm -
2 stops50h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$346
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:15 am -
1 stop8h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$379
Find flight deals from Roanoke to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $373 (United Airlines) |
One-way from | $239 (Kiwi.com) |
Popular in | December |
Cheapest in | September |
Average price | $375 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
Use the filters below to find and compare flights from Roanoke to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Sat 11/21
11:46 am-3:48 pm
2 stops31h 02m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$310
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Fri 11/20
4:27 pm-3:48 pm
2 stops50h 21m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$346
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Sat 10/10
3:06 pm-8:46 pm
1 stop8h 40m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$379
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Sun 10/4
6:15 am-11:22 am
1 stop8h 07m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$379
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Sat 11/21
2:55 pm-10:07 pm
1 stop10h 12m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$379
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Wed 10/7
8:05 pm-12:59 am
1 stop7h 54m
San Francisco
Sun 10/11
10:42 pm-9:57 am
1 stop8h 15m
$379
Quickest round-trip
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Sat 10/10
6:49 am-11:25 am
1 stop7h 36m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$389
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Sun 11/1
4:53 pm-9:47 pm
1 stop7h 54m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$389
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Sat 12/12
2:04 pm-9:27 pm
1 stop10h 23m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$389
RoanokeSan Francisco
ROA Roanoke - SFO San Francisco
ROASFO
Roanoke
Sat 11/21
6:54 pm-11:58 pm
1 stop8h 04m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$399
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Roanoke to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Roanoke to San Francisco in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Roanoke-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Roanoke-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Roanoke-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Roanoke-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Roanoke-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Roanoke to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Roanoke with our price prediction graph.
ROA-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to San Francisco
How far ahead should I book a flight from Roanoke to San Francisco?
Booking 28 days in advance of your planned departure date is, on average, the best time to get cheap flights from Roanoke to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Roanoke to San Francisco?
Currently, September is the cheapest month in which you can book a flight from Roanoke to San Francisco (average of $375). Flying from Roanoke to San Francisco in December is currently the most expensive (average of $609). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Roanoke to San Francisco?
Airfare is typical for this route at the moment.
Roanoke to San Francisco flights typically cost between $372 and $455 in October.The cheapest round-trip price found within the last 5 days was $373 on United Airlines (Oct 31-Nov 3).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 14, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Roanoke to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Overall
7.8
Boarding
8.1
Entertainment
7.8
Comfort
7.8
Crew
8.5
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Roanoke to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
San Bruno
Burlingame
Rancho Cordova
Roseville
Fairfield
Cupertino
Newark
Hayward
San Ramon
Redwood City
Manteca
Vallejo
San Carlos
Turlock
Davis
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Find flights from Roanoke to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Roanoke and San Francisco flights
Browse other Roanoke and San Francisco flight options. Last updated on September 14, 2026.
Other flights from Roanoke
Browse through other flights departing from Roanoke. Flights are based on user searches made on Cheapflights and were last updated on September 14, 2026.
Popular flight searches
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Other flights to San Francisco
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Top 3 airlines flying from Roanoke to San Francisco
Discover the top 3 airlines that operate flights from Roanoke to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$308 | Average$473 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$318 | Average$422 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$322 | Average$487 | FlexibilityNo cancel fee | On-time71% |