$187+ Cheap flights from Roanoke to San Francisco (ROA - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — SFO
Aug 28 — Sep 41
Round-trip
1 adult, Economy
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Find cheap flights from Roanoke to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Roanoke to San Francisco
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Best
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Cheapest flights from Roanoke to San FranciscoExplore the most affordable flight options available from Roanoke to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
Explore the most affordable flight options available from Roanoke to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:12 pm
ROA
- SFO
1 stop9h 55m
American Airlines
Tue 12/18:30 am
SFO
- ROA
1 stop9h 03m
American Airlines
Deal found 7/26![American Airlines logo]()
$373
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:57 pm
ROA
- SFO
1 stop9h 11m
American Airlines
Sun 9/1311:03 pm
SFO
- ROA
1 stop7h 38m
American Airlines
Deal found 7/26![American Airlines logo]()
$376
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:07 am
ROA
- SFO
1 stop8h 30m
American Airlines
Fri 8/2812:33 pm
SFO
- ROA
1 stop7h 16m
American Airlines
Deal found 7/26![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:38 pm
ROA
- SFO
1 stop7h 21m
Delta
Sun 10/1110:30 pm
SFO
- ROA
1 stop9h 02m
Delta
Deal found 7/28![Delta logo]()
$416
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:35 pm
ROA
- SFO
1 stop9h 10m
American Airlines
Wed 8/197:00 am
SFO
- ROA
1 stop10h 30m
American Airlines
Deal found 7/27![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:13 pm
ROA
- SFO
2 stops13h 43m
Delta
Tue 12/110:59 pm
SFO
- ROA
1 stop8h 39m
Delta
Deal found 7/26![Delta logo]()
$439
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:07 pm
ROA
- SFO
1 stop8h 33m
American Airlines
Sat 8/2212:29 pm
SFO
- ROA
1 stop7h 20m
American Airlines
Deal found 7/26![American Airlines logo]()
$445
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:59 pm
ROA
- SFO
1 stop7h 57m
Delta
Mon 10/128:59 pm
SFO
- ROA
2 stops10h 33m
Delta
Deal found 7/27![Delta logo]()
$452
Best flights from Roanoke to San FranciscoDiscover carefully curated flight deals from Roanoke to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
Discover carefully curated flight deals from Roanoke to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 29, 2026.
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:05 pm
ROA
- SFO
1 stop7h 54m
United Airlines
Mon 9/711:30 pm
SFO
- ROA
1 stop7h 29m
United Airlines
Deal found 7/24![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:38 pm
ROA
- SFO
1 stop7h 21m
Delta
Sun 10/1110:30 pm
SFO
- ROA
1 stop9h 02m
Delta
Deal found 7/28![Delta logo]()
$416
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:18 am
ROA
- SFO
2 stops12h 01m
Delta
Tue 12/110:59 pm
SFO
- ROA
1 stop8h 39m
Delta
Deal found 7/26![Delta logo]()
$439
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am
ROA
- SFO
2 stops14h 05m
Delta
Sat 11/79:30 pm
SFO
- ROA
1 stop10h 02m
Delta
Deal found 7/27![Delta logo]()
$439
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:05 pm
ROA
- SFO
1 stop7h 54m
United Airlines
Sun 10/2510:45 pm
SFO
- ROA
1 stop8h 02m
United Airlines
Deal found 7/26![United Airlines logo]()
$486
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:18 am
ROA
- SFO
2 stops12h 01m
Delta
Tue 11/1711:51 am
SFO
- ROA
1 stop9h 36m
Delta
Deal found 7/28![Delta logo]()
$439
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:50 pm
ROA
- SFO
1 stop8h 05m
United Airlines
Sun 8/2311:30 pm
SFO
- ROA
1 stop7h 39m
United Airlines
Deal found 7/26![United Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:20 am
ROA
- SFO
1 stop10h 20m
United Airlines
Mon 12/711:30 pm
SFO
- ROA
1 stop7h 41m
United Airlines
Deal found 7/24![United Airlines logo]()
$623
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:26 am
ROA
- SFO
1 stop10h 09m
United Airlines
Sun 8/165:00 am
SFO
- ROA
1 stop9h 09m
United Airlines
Deal found 7/28![United Airlines logo]()
$668
Last-minute flights from Roanoke to San FranciscoDiscover last-minute flight deals from Roanoke to San Francisco. Data last updated July 29, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to San Francisco. Data last updated July 29, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/34:48 pm
ROA
- SFO
1 stop9h 00m
American Airlines
Thu 8/1312:33 pm
SFO
- ROA
1 stop7h 16m
American Airlines
Deal found 7/27![American Airlines logo]()
$509
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:35 pm
ROA
- SFO
1 stop9h 10m
American Airlines
Wed 8/197:00 am
SFO
- ROA
1 stop10h 30m
American Airlines
Deal found 7/27![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:07 pm
ROA
- SFO
1 stop8h 33m
American Airlines
Sat 8/2212:29 pm
SFO
- ROA
1 stop7h 20m
American Airlines
Deal found 7/26![American Airlines logo]()
$445
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:07 am
ROA
- SFO
1 stop8h 30m
American Airlines
Fri 8/2812:33 pm
SFO
- ROA
1 stop7h 16m
American Airlines
Deal found 7/26![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:00 am
ROA
- SFO
1 stop8h 55m
Delta
Mon 8/246:20 am
SFO
- ROA
2 stops9h 59m
Delta
Deal found 7/27![Delta logo]()
$487
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:50 pm
ROA
- SFO
1 stop8h 05m
United Airlines
Sun 8/2311:30 pm
SFO
- ROA
1 stop7h 39m
United Airlines
Deal found 7/26![United Airlines logo]()
$489
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:50 pm
ROA
- SFO
1 stop9h 26m
United Airlines
Sat 8/291:15 pm
SFO
- ROA
1 stop7h 28m
United Airlines
Deal found 7/25![United Airlines logo]()
$376
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:11 am
ROA
- SFO
2 stops10h 51m
American Airlines
Sat 8/295:05 am
SFO
- ROA
1 stop8h 37m
American Airlines
Deal found 7/25![American Airlines logo]()
$447
One-way flights from Roanoke to San FranciscoSearch for one-way flight options from Roanoke to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
Search for one-way flight options from Roanoke to San Francisco. Find affordable one-way fares based on user searches. Data last updated July 29, 2026.
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/64:58 pm
ROA
- SFO
1 stop8h 42m
American Airlines
Deal found 7/27![American Airlines logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:36 pm
ROA
- SFO
3 stops46h 49m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:12 am
ROA
- SFO
2 stops36h 56m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/103:27 pm
ROA
- SFO
3 stops45h 58m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:36 pm
ROA
- SFO
3 stops31h 27m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/610:46 am
ROA
- SFO
3 stops52h 06m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2310:51 am
ROA
- SFO
3 stops50h 34m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$326
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:08 pm
ROA
- SFO
1 stop9h 01m
American Airlines
Deal found 7/27![American Airlines logo]()
$379
Find flight deals from Roanoke to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Roanoke (ROA) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $371 (American Airlines) |
One-way from | $187 (American Airlines) |
Popular in | December |
Cheapest in | November |
Average price | $516 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Roanoke to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Thu 9/3
8:05 pm-12:59 am
1 stop7h 54m
San Francisco
Mon 9/7
11:30 pm-9:59 am
1 stop7h 29m
$379
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Wed 10/7
6:38 pm-10:59 pm
1 stop7h 21m
San Francisco
Sun 10/11
10:30 pm-10:32 am
1 stop9h 02m
$416
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Wed 11/18
11:18 am-8:19 pm
2 stops12h 01m
San Francisco
Tue 12/1
10:59 pm-10:38 am
1 stop8h 39m
$439
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Wed 11/4
6:00 am-5:05 pm
2 stops14h 05m
San Francisco
Sat 11/7
9:30 pm-10:32 am
1 stop10h 02m
$439
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Tue 11/10
11:18 am-8:19 pm
2 stops12h 01m
San Francisco
Tue 11/17
11:51 am-12:27 am
1 stop9h 36m
$439
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Wed 10/21
8:05 pm-12:59 am
1 stop7h 54m
San Francisco
Sun 10/25
10:45 pm-9:47 am
1 stop8h 02m
$486
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Fri 8/21
5:50 pm-10:55 pm
1 stop8h 05m
San Francisco
Sun 8/23
11:30 pm-10:09 am
1 stop7h 39m
$489
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Thu 12/3
10:20 am-5:40 pm
1 stop10h 20m
San Francisco
Mon 12/7
11:30 pm-10:11 am
1 stop7h 41m
$623
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Wed 8/12
10:26 am-5:35 pm
1 stop10h 09m
San Francisco
Sun 8/16
5:00 am-5:09 pm
1 stop9h 09m
$668
Cheapest one-way
RoanokeSan Francisco
ROA - SFO
ROASFO
Roanoke
Mon 8/24
2:36 pm-7:03 pm
2 stops31h 27m
$212
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Roanoke to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Roanoke to San Francisco in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Roanoke-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Roanoke-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Roanoke-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Roanoke-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Roanoke-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Roanoke to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Roanoke with our price prediction graph.
ROA-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to San Francisco
How far ahead should I book a flight from Roanoke to San Francisco?
Booking 28 days in advance of your planned departure date is, on average, the best time to get cheap flights from Roanoke to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Roanoke to San Francisco?
Currently, November is the cheapest month in which you can book a flight from Roanoke to San Francisco (average of $338). Flying from Roanoke to San Francisco in December is currently the most expensive (average of $609). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Roanoke to San Francisco?
Airfare is below average for this route at the moment.
Roanoke to San Francisco flights typically cost between $408 and $553 in October.The cheapest round-trip price found within the last 5 days was $373 on American Airlines (Oct 31-Dec 1).
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated July 29, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Roanoke to San Francisco have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.2
Crew
8.5
Comfort
7.8
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Food
7.2
Crew
8.5
Comfort
7.8
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Food
7.2
Crew
8.5
Comfort
7.8
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Boarding
8.1
Food
7.2
Crew
8.5
Comfort
7.8
Overall
7.8
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
TUS - LAX
Related info for your journey
Find useful and relevant information for your journey from Roanoke to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Fairfield
Emeryville
Roseville
Burlingame
Rancho Cordova
San Bruno
Cupertino
Newark
Hayward
San Ramon
Redwood City
San Carlos
Turlock
Vallejo
San Lorenzo
Davis
Vacaville
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Find flights from Roanoke to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Roanoke and San Francisco flights
Browse other Roanoke and San Francisco flight options. Last updated on July 29, 2026.
Other flights from Roanoke
Browse through other flights departing from Roanoke. Flights are based on user searches made on Cheapflights and were last updated on July 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 29, 2026.
Top 3 airlines flying from Roanoke to San Francisco
Discover the top 3 airlines that operate flights from Roanoke to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$308 | Average$468 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$308 | Average$474 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$318 | Average$511 | FlexibilityNo cancel fee | On-timeN/A |