How long is the flight from Myrtle Beach to San Francisco?

A quick flight from Myrtle Beach to San Francisco can take about 7h 50m. American Airlines provides one of the quickest options available for as low as $347. Myrtle Beach and San Francisco are separated by a distance of 2431 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?

Currently priced at $250, Delta will fly you from Myrtle Beach to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $312. You may be able to fly from Myrtle Beach to San Francisco for 43% less than the average price by searching for these airlines.

What is the cheapest day to fly from Myrtle Beach to San Francisco?

Travelers seeking maximum savings on their Myrtle Beach to San Francisco flight should consider departing on Tuesday mornings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Most accurate provider : When it comes to deals on Myrtle Beach-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Myrtle Beach-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?

Yes. In addition to deals on Myrtle Beach to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Myrtle Beach to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Francisco.

Can I find deals for business class flights from Myrtle Beach to San Francisco?

Yes. Cheapflights offers flight deals from Myrtle Beach to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$144+ Flights from Myrtle Beach to San Francisco

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1. Tell us where you want to go

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Cheap flight deals from Myrtle Beach to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$287 (American Airlines)
One-way from	$144 (American Airlines)
Popular in	December
Cheapest in	April
Average price	$416

Provider with most accurate pricing for Myrtle Beach Intl-San Francisco flight deals.

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Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Francisco flights.

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From Myrtle Beach Intl to San Francisco

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One-way flight from Myrtle Beach Intl to San Francisco

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Highest demand for flights based on searches. 2% potential increase in price ($13 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from Myrtle Beach to San Francisco

Cheapest flights from Myrtle Beach to San Francisco
Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2025.

Wed 10/2212:18 pmMYR - SFO

1 stop10h 05mAmerican Airlines

Wed 10/2911:36 pmSFO - MYR

1 stop8h 52mAmerican Airlines

Deal found 9/27

$287

Tue 10/214:47 pmMYR - SFO

1 stop9h 42mAmerican Airlines

Fri 10/247:04 amSFO - MYR

1 stop8h 41mAmerican Airlines

Deal found 9/27

$347

Thu 10/306:55 amMYR - SFO

2 stops11h 30mSouthwest

Sat 11/85:15 pmSFO - MYR

2 stops14h 20mSouthwest

Deal found 9/28

$357

Wed 10/87:00 amMYR - SFO

1 stop7h 51mAmerican Airlines

Wed 10/227:04 amSFO - MYR

1 stop8h 41mAmerican Airlines

Deal found 9/27

$517

Thu 10/164:43 pmMYR - SFO

1 stop9h 40mAmerican Airlines

Mon 10/2011:30 amSFO - MYR

2 stops9h 29mAmerican Airlines

Deal found 9/27

$532

Best flights from Myrtle Beach to San Francisco
Discover carefully curated flight deals from Myrtle Beach to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2025.

Wed 10/2212:18 pmMYR - SFO

1 stop10h 05mAmerican Airlines

Wed 10/2911:36 pmSFO - MYR

1 stop8h 52mAmerican Airlines

Deal found 9/27

$287

Thu 10/3010:40 amMYR - SFO

1 stop7h 50mSouthwest

Sat 11/89:25 pmSFO - MYR

1 stop10h 10mSouthwest

Deal found 9/28

$347

Thu 10/305:36 pmMYR - SFO

1 stop7h 20mAmerican Airlines

Fri 11/712:27 amSFO - MYR

1 stop7h 06mAmerican Airlines

Deal found 9/28

$347

Tue 10/217:00 amMYR - SFO

1 stop10h 49mAmerican Airlines

Fri 10/2410:15 pmSFO - MYR

1 stop7h 45mAmerican Airlines

Deal found 9/28

$347

Wed 1/288:15 amMYR - SFO

2 stops11h 50mSouthwest

Sun 2/159:30 pmSFO - MYR

1 stop9h 25mSouthwest

Deal found 9/27

$392

Wed 1/282:27 pmMYR - SFO

1 stop7h 39mAmerican Airlines

Sun 2/159:33 amSFO - MYR

1 stop6h 40mAmerican Airlines

Deal found 9/27

$387

Last-minute flights from Myrtle Beach to San Francisco
Discover last-minute flight deals from Myrtle Beach to San Francisco. Data last updated September 29, 2025 and is based on user searches.

Wed 10/87:00 amMYR - SFO

1 stop7h 51mAmerican Airlines

Wed 10/227:04 amSFO - MYR

1 stop8h 41mAmerican Airlines

Deal found 9/27

$517

Thu 10/164:43 pmMYR - SFO

1 stop9h 40mAmerican Airlines

Mon 10/2011:30 amSFO - MYR

2 stops9h 29mAmerican Airlines

Deal found 9/27

$532

Tue 10/214:47 pmMYR - SFO

1 stop9h 42mAmerican Airlines

Fri 10/247:04 amSFO - MYR

1 stop8h 41mAmerican Airlines

Deal found 9/27

$347

Wed 10/2212:18 pmMYR - SFO

1 stop10h 05mAmerican Airlines

Wed 10/2911:36 pmSFO - MYR

1 stop8h 52mAmerican Airlines

Deal found 9/27

$287

Thu 10/306:55 amMYR - SFO

2 stops11h 30mSouthwest

Sat 11/85:15 pmSFO - MYR

2 stops14h 20mSouthwest

Deal found 9/28

$357

One-way flights from Myrtle Beach to San Francisco
Search for one-way flight options from Myrtle Beach to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 29, 2025.

Tue 11/187:30 amMYR - SFO

1 stop9h 08mAmerican Airlines

Deal found 9/29

$144

Mon 10/276:58 pmMYR - SFO

1 stop8h 07mDelta

Deal found 9/27

$164

Mon 10/279:25 pmMYR - SFO

2 stops28h 02mMultiple Airlines

Deal found 9/27

$180

Sun 10/267:58 pmMYR - SFO

2 stops27h 40mMultiple Airlines

Deal found 9/27

$187

Tue 11/1811:13 amMYR - SFO

3 stops27h 41mMultiple Airlines

Deal found 9/29

$217

Sun 11/96:05 amMYR - SFO

1 stop9h 25mAmerican Airlines

Deal found 9/28

$224

Tue 12/307:00 amMYR - SFO

1 stop12h 00mSouthwest

Deal found 9/28

$229

Sun 10/265:21 amMYR - SFO

1 stop10h 10mAmerican Airlines

Deal found 9/27

$254

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 10/22

12:18 pm-7:23 pm

1 stop10h 05m

San Francisco

Wed 10/29

11:36 pm-11:28 am

1 stop8h 52m

$287

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 10/30

10:40 am-3:30 pm

1 stop7h 50m

San Francisco

Sat 11/8

9:25 pm-10:35 am

1 stop10h 10m

$347

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 10/30

5:36 pm-9:56 pm

1 stop7h 20m

San Francisco

Fri 11/7

12:27 am-10:33 am

1 stop7h 06m

$347

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 10/21

7:00 am-2:49 pm

1 stop10h 49m

San Francisco

Fri 10/24

10:15 pm-9:00 am

1 stop7h 45m

$347

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 1/28

2:27 pm-7:06 pm

1 stop7h 39m

San Francisco

Sun 2/15

9:33 am-7:13 pm

1 stop6h 40m

$387

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 1/28

8:15 am-5:05 pm

2 stops11h 50m

San Francisco

Sun 2/15

9:30 pm-9:55 am

1 stop9h 25m

$392

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 11/18

7:30 am-1:38 pm

1 stop9h 08m

$144

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Mon 10/27

6:58 pm-12:05 am

1 stop8h 07m

$164

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 11/18

11:13 am-11:54 am

3 stops27h 41m

$217

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sun 10/26

9:05 pm-7:13 pm

3 stops25h 08m

$220

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/29

Showing 1-10 of 15 results

Compare providers for flights from Myrtle Beach to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Francisco in September.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Myrtle Beach-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Myrtle Beach-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Myrtle Beach with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Francisco

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $276). Flying from Myrtle Beach to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SFO?

One of the essential ways to save on airfare from Myrtle Beach to San Francisco is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight at noon could potentially save you up to 8% on airfare.

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with Delta and American Airlines from Myrtle Beach to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,964 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,964 reviews

Delta

8.0

Very good

7,964 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,964 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

How long is the flight from Myrtle Beach to San Francisco?
A quick flight from Myrtle Beach to San Francisco can take about 7h 50m. American Airlines provides one of the quickest options available for as low as $347. Myrtle Beach and San Francisco are separated by a distance of 2431 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?
Currently priced at $250, Delta will fly you from Myrtle Beach to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $312. You may be able to fly from Myrtle Beach to San Francisco for 43% less than the average price by searching for these airlines.
Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?
Yes. In addition to deals on Myrtle Beach to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Myrtle Beach to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Francisco.
Can I find deals for business class flights from Myrtle Beach to San Francisco?
Yes. Cheapflights offers flight deals from Myrtle Beach to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Myrtle Beach to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $276). Flying from Myrtle Beach to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Santa Cruz

Livermore

South San Francisco

Turlock

Antioch

Watsonville

Santa Clara

Manteca

Sunnyvale

Hollister

Vacaville

Foster City

Union City

Vallejo

Fairfield

Burlingame

Redwood City

San Mateo

San Leandro

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Myrtle Beach to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$250	Average$410	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$312	Average$471	FlexibilityNo cancel fee	On-time71%

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$144+ Cheap flights from Myrtle Beach to San Francisco (MYR - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Myrtle Beach to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Myrtle Beach to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Myrtle Beach to San Francisco

Cheapest flights from Myrtle Beach to San FranciscoExplore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2025.

Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Compare providers for flights from Myrtle Beach to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Francisco in September.

Best time to book a flight from Myrtle Beach to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Myrtle Beach with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Francisco

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

What is the cheapest time of day to fly from MYR to SFO?

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with Delta and American Airlines from Myrtle Beach to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Myrtle Beach to San Francisco?

What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?

Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?

How can I find direct flights from Myrtle Beach to San Francisco?

Can I find deals for business class flights from Myrtle Beach to San Francisco?

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Myrtle Beach to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Myrtle Beach to San Francisco

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Cheapest flights from Myrtle Beach to San Francisco
Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2025.