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$166+ Cheap flights from Myrtle Beach to San Francisco (MYR - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SFO
May 1 — May 81
Fri 5/1
Fri 5/8
1 adult, Economy
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Cheap flight deals from Myrtle Beach to San Francisco

Cheapest flights from Myrtle Beach to San Francisco
Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.

This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:57 am
MYR
-
SFO
1 stop11h 37m
United Airlines
Tue 4/2811:52 pm
SFO
-
MYR
1 stop7h 26m
United Airlines
Deal found 3/28$397
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/214:05 pm
MYR
-
SFO
1 stop7h 50m
Southwest
Tue 4/285:25 am
SFO
-
MYR
2 stops12h 05m
Southwest
Deal found 3/28$402
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:50 pm
MYR
-
SFO
1 stop9h 13m
Delta
Tue 4/2810:55 pm
SFO
-
MYR
1 stop10h 00m
Delta
Deal found 3/29$406
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:45 pm
MYR
-
SFO
2 stops11h 25m
Southwest
Tue 4/289:15 pm
SFO
-
MYR
1 stop10h 20m
Southwest
Deal found 3/29$411
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:30 pm
MYR
-
SFO
1 stop7h 45m
American Airlines
Wed 5/276:54 pm
SFO
-
MYR
2 stops10h 47m
American Airlines
Deal found 3/27$412
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:45 pm
MYR
-
SFO
2 stops11h 25m
Southwest
Sat 5/1611:25 pm
SFO
-
MYR
1 stop13h 45m
Southwest
Deal found 3/27$417
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:35 am
MYR
-
SFO
2 stops15h 20m
Southwest
Wed 5/277:15 pm
SFO
-
MYR
2 stops11h 50m
Southwest
Deal found 3/27$422
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:05 pm
MYR
-
SFO
1 stop7h 50m
Southwest
Sun 4/265:20 am
SFO
-
MYR
1 stop7h 50m
Southwest
Deal found 3/27$432
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/94:38 pm
MYR
-
SFO
1 stop8h 52m
American Airlines
Sat 6/135:00 am
SFO
-
MYR
1 stop9h 32m
American Airlines
Deal found 3/31$436

Find flight deals from Myrtle Beach to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$397
(United Airlines)

One-way from

$166
(Kiwi.com)

Popular in

November

Cheapest in

October

Average price

$410
Provider with most accurate pricing for Myrtle Beach Intl-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Francisco flights.
Search Deals
From Myrtle Beach Intl to San Francisco
Search Deals
One-way flight from Myrtle Beach Intl to San Francisco
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($95 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 4/23

3:45 pm-12:10 am

2 stops11h 25m

San Francisco

Tue 4/28

5:25 am-8:30 pm

2 stops12h 05m

$416

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 5/20

7:35 am-7:55 pm

2 stops15h 20m

San Francisco

Wed 5/27

7:15 pm-10:05 am

2 stops11h 50m

$422

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 4/22

4:05 pm-8:55 pm

1 stop7h 50m

San Francisco

Sun 4/26

5:20 am-4:10 pm

1 stop7h 50m

$432

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 4/30

1:45 pm-10:25 pm

2 stops11h 40m

San Francisco

Sun 5/3

5:20 am-4:10 pm

1 stop7h 50m

$446

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 6/9

6:06 pm-12:48 am

2 stops9h 42m

San Francisco

Sat 6/13

5:00 am-5:32 pm

1 stop9h 32m

$459
Quickest round-trip

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Mon 5/4

7:03 pm-11:55 pm

1 stop7h 52m

San Francisco

Fri 5/8

1:45 pm-11:58 pm

1 stop7h 13m

$467

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 7/15

2:10 pm-7:50 pm

1 stop8h 40m

San Francisco

Wed 7/22

9:10 pm-9:55 am

1 stop9h 45m

$467

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sun 8/23

7:30 am-1:10 pm

1 stop8h 40m

San Francisco

Thu 8/27

5:35 am-5:35 pm

1 stop9h 00m

$467

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 6/11

7:15 pm-12:10 am

1 stop7h 55m

San Francisco

Tue 6/16

5:30 am-8:30 pm

2 stops12h 00m

$472
Cheapest one-way

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 5/6

3:17 pm-11:04 pm

2 stops34h 47m

$171

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/29

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Myrtle Beach to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Francisco in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Francisco

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

Currently, November is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $160). Flying from Myrtle Beach to San Francisco in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Myrtle Beach to San Francisco?

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated April 1, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Myrtle Beach to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,368 reviews

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,368 reviews
Delta
7.9
Good
8,368 reviews

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.1
Good
11,544 reviews
Delta
7.9
Good
8,368 reviews

Overall

7.9

Boarding

8.1

Food

7.2

Comfort

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to San Francisco?

    A quick flight from Myrtle Beach to San Francisco can take about 9h 42m. Southwest provides one of the quickest options available for as low as $459. Myrtle Beach and San Francisco are separated by a distance of 2431 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?

    Currently priced at $312, American Airlines will fly you from Myrtle Beach to San Francisco and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $312. You may be able to fly from Myrtle Beach to San Francisco for 35% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Myrtle Beach to San Francisco one-way?

    $156 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and Southwest, with prices starting from $175 and $228, respectively.

  • Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Francisco.

  • Can I find deals for business class flights from Myrtle Beach to San Francisco?

    Yes. Cheapflights offers flight deals from Myrtle Beach to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

    Currently, November is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $160). Flying from Myrtle Beach to San Francisco in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Rancho Cordova
San Bruno
Watsonville
San Ramon
Sunnyvale
Vacaville
San Carlos
Redwood City
Turlock
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Foster City

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Alternative routes for Myrtle Beach to San Francisco

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Top 2 airlines flying from Myrtle Beach to San Francisco

Discover the top 2 airlines that operate flights from Myrtle Beach to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$312Average$450FlexibilityNo cancel feeOn-time71%
DeltaCheapest$312Average$472FlexibilityNo cancel feeOn-timeN/A

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