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$123+ Cheap flights from Myrtle Beach to San Francisco (MYR - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SFO
Dec 12 — Dec 191
Fri 12/12
Fri 12/19
1 adult, Economy
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Cheap flight deals from Myrtle Beach to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$367
(American Airlines)

One-way from

$123
(Kiwi.com)

Popular in

February

Cheapest in

April

Average price

$691
Provider with most accurate pricing for Myrtle Beach Intl-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Francisco flights.
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From Myrtle Beach Intl to San Francisco
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One-way flight from Myrtle Beach Intl to San Francisco
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Highest demand for flights based on searches. 15% potential increase in price ($90 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Myrtle Beach to San Francisco

Cheapest flights from Myrtle Beach to San Francisco
Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:29 pmMYR - SFO
1 stop9h 40mAmerican Airlines
Wed 12/177:00 amSFO - MYR
1 stop6h 39mAmerican Airlines
Deal found 11/11$367
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:55 pmMYR - SFO
2 stops10h 35mSouthwest
Wed 12/176:10 amSFO - MYR
1 stop8h 15mSouthwest
Deal found 11/10$372
This Southwest deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/98:00 amMYR - SFO
1 stop8h 20mSouthwest
Sat 12/208:25 pmSFO - MYR
2 stops12h 40mSouthwest
Deal found 11/11$418
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:18 pmMYR - SFO
1 stop10h 32mDelta
Sat 12/2710:30 pmSFO - MYR
1 stop8h 54mDelta
Deal found 11/11$429
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:43 pmMYR - SFO
1 stop8h 42mAmerican Airlines
Sun 12/711:50 pmSFO - MYR
1 stop8h 49mAmerican Airlines
Deal found 11/11$443
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:59 pmMYR - SFO
1 stop7h 58mDelta
Sun 12/2810:30 pmSFO - MYR
1 stop8h 54mDelta
Deal found 11/11$447

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Myrtle Beach

Fly to

San Francisco

Route

Depart

Return

Price

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 12/10

3:29 pm-10:09 pm

1 stop9h 40m

San Francisco

Wed 12/17

7:00 am-4:39 pm

1 stop6h 39m

$367

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 12/10

2:55 pm-10:30 pm

2 stops10h 35m

San Francisco

Wed 12/17

6:10 am-5:25 pm

1 stop8h 15m

$372

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 1/6

8:00 am-1:50 pm

1 stop8h 50m

San Francisco

Thu 1/8

12:17 am-1:23 pm

2 stops10h 06m

$412

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 12/9

8:00 am-1:20 pm

1 stop8h 20m

San Francisco

Sat 12/20

8:25 pm-12:05 pm

2 stops12h 40m

$418

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 12/24

1:18 pm-8:50 pm

1 stop10h 32m

San Francisco

Sat 12/27

10:30 pm-10:24 am

1 stop8h 54m

$429

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 12/25

5:12 pm-11:57 pm

1 stop9h 45m

San Francisco

Wed 12/31

10:45 pm-10:42 am

1 stop8h 57m

$429

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 12/3

5:43 pm-11:25 pm

1 stop8h 42m

San Francisco

Sun 12/7

11:50 pm-11:39 am

1 stop8h 49m

$443

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 12/25

5:13 pm-10:51 pm

1 stop8h 38m

San Francisco

Thu 1/1

9:00 am-7:11 pm

1 stop7h 11m

$443

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Mon 12/22

6:59 pm-11:57 pm

1 stop7h 58m

San Francisco

Sun 12/28

10:30 pm-10:24 am

1 stop8h 54m

$447

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Thu 1/29

4:01 pm-12:25 am

2 stops35h 24m

$123

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 17 results
1
2

Compare providers for flights from Myrtle Beach to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Francisco in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Francisco

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

Currently, November is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $163). Flying from Myrtle Beach to San Francisco in March is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SFO?

Find hourly flight availability from Myrtle Beach to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 12, 2025.

One of the essential ways to save on airfare from Myrtle Beach to San Francisco is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 7% on airfare.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 12, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Myrtle Beach to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,009 reviews
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to San Francisco?

    A quick flight from Myrtle Beach to San Francisco can take about 9h 40m. American Airlines provides one of the quickest options available for as low as $367. Myrtle Beach and San Francisco are separated by a distance of 2431 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?

    Currently priced at $250, Delta will fly you from Myrtle Beach to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $312. You may be able to fly from Myrtle Beach to San Francisco for 49% less than the average price by searching for these airlines.

  • Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Francisco.

  • Can I find deals for business class flights from Myrtle Beach to San Francisco?

    Yes. Cheapflights offers flight deals from Myrtle Beach to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

    Currently, November is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $163). Flying from Myrtle Beach to San Francisco in March is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Sunnyvale
Santa Clara
Vallejo
Hollister
San Bruno
Foster City
Redwood City
Union City
Burlingame
Lodi
San Mateo
Vacaville
Lathrop

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Top 2 airlines flying from Myrtle Beach to San Francisco

Discover the top 2 airlines that operate flights from Myrtle Beach to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$250Average$410FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$312Average$445FlexibilityNo cancel feeOn-time71%

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