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$132+ Cheap flights from Myrtle Beach to San Francisco (MYR - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/12. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SFO
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Myrtle Beach to San Francisco

Cheapest flights from Myrtle Beach to San Francisco
Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:16 pm
MYR
-
SFO
1 stop9h 17m
Delta
Tue 3/3112:06 pm
SFO
-
MYR
1 stop8h 58m
Delta
Deal found 2/9$359
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:01 am
MYR
-
SFO
2 stops11h 33m
American Airlines
Tue 3/3111:29 pm
SFO
-
MYR
1 stop9h 17m
American Airlines
Deal found 2/11$364
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/103:40 pm
MYR
-
SFO
2 stops11h 05m
Southwest
Tue 3/177:20 pm
SFO
-
MYR
2 stops11h 45m
Southwest
Deal found 2/8$369
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/74:05 pm
MYR
-
SFO
1 stop7h 50m
Southwest
Mon 4/139:15 pm
SFO
-
MYR
1 stop10h 20m
Southwest
Deal found 2/11$374
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:15 pm
MYR
-
SFO
1 stop10h 25m
United Airlines
Mon 4/2711:52 pm
SFO
-
MYR
1 stop7h 26m
United Airlines
Deal found 2/10$389
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/233:45 pm
MYR
-
SFO
2 stops11h 00m
Southwest
Mon 4/279:15 pm
SFO
-
MYR
1 stop10h 20m
Southwest
Deal found 2/10$394

Find flight deals from Myrtle Beach to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$359
(Delta)

One-way from

$132
(Kiwi.com)

Popular in

November

Cheapest in

April

Average price

$579
Provider with most accurate pricing for Myrtle Beach Intl-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Francisco flights.
Search Deals
From Myrtle Beach Intl to San Francisco
Search Deals
One-way flight from Myrtle Beach Intl to San Francisco
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($102 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Myrtle Beach

Fly to

San Francisco

Route

Depart

Return

Price

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/24

5:38 pm-11:25 pm

1 stop8h 47m

San Francisco

Tue 3/31

6:00 am-4:33 pm

1 stop7h 33m

$359

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/10

3:40 pm-10:05 pm

1 stop9h 25m

San Francisco

Tue 3/17

9:20 pm-10:05 am

1 stop9h 45m

$359

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 3/24

2:16 pm-8:33 pm

1 stop9h 17m

San Francisco

Tue 3/31

12:06 pm-12:04 am

1 stop8h 58m

$359

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 5/13

3:14 pm-10:38 pm

1 stop10h 24m

San Francisco

Mon 5/18

12:45 am-2:18 pm

1 stop10h 33m

$359

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 5/13

4:09 pm-9:28 pm

1 stop8h 19m

San Francisco

Tue 5/19

6:45 pm-8:23 am

2 stops10h 38m

$364

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 4/7

4:05 pm-8:55 pm

1 stop7h 50m

San Francisco

Mon 4/13

9:15 pm-10:35 am

1 stop10h 20m

$374

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 5/12

7:31 pm-11:25 pm

3 stops30h 54m

$132

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 5/12

4:52 pm-9:57 pm

1 stop8h 05m

$180

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 3/14

9:49 pm-7:14 pm

3 stops48h 25m

$219

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sat 3/14

7:15 pm-12:20 am

1 stop8h 05m

$220

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/10

Showing 1-10 of 16 results
1
2

Compare providers for flights from Myrtle Beach to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to San Francisco in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Francisco

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

Currently, November is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $160). Flying from Myrtle Beach to San Francisco in March is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 11, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Myrtle Beach to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,180 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,180 reviews
Delta
7.9
Good
8,180 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,271 reviews
Delta
7.9
Good
8,180 reviews

Boarding

8.1

Overall

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to San Francisco?

    A quick flight from Myrtle Beach to San Francisco can take about 9h 17m. Delta provides one of the quickest options available for as low as $359. Myrtle Beach and San Francisco are separated by a distance of 2431 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?

    Currently priced at $250, Delta will fly you from Myrtle Beach to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $312. You may be able to fly from Myrtle Beach to San Francisco for 47% less than the average price by searching for these airlines.

  • Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Francisco.

  • Can I find deals for business class flights from Myrtle Beach to San Francisco?

    Yes. Cheapflights offers flight deals from Myrtle Beach to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

    Currently, November is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $160). Flying from Myrtle Beach to San Francisco in March is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Santa Cruz
South San Francisco
Santa Clara
Roseville
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City

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Alternative routes for Myrtle Beach to San Francisco

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Top 2 airlines flying from Myrtle Beach to San Francisco

Discover the top 2 airlines that operate flights from Myrtle Beach to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$250Average$410FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$312Average$426FlexibilityNo cancel feeOn-time71%

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