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$164+ Cheap flights from Myrtle Beach to San Francisco (MYR - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SFO
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Myrtle Beach to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$283
(American Airlines)

One-way from

$164
(Kiwi.com)

Popular in

August

Cheapest in

April

Average price

$548
From Myrtle Beach Intl to San Francisco
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One-way flight from Myrtle Beach Intl to San Francisco
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Highest demand for flights based on searches. 1% potential increase in price ($8 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Myrtle Beach to San Francisco

Cheapest flights from Myrtle Beach to San Francisco
Explore the most affordable flight options available from Myrtle Beach to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/87:00 amMYR - SFO
1 stop7h 51mAmerican Airlines
Wed 10/227:04 amSFO - MYR
1 stop8h 41mAmerican Airlines
Deal found 8/14$283
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/176:15 amMYR - SFO
2 stops9h 53mAmerican Airlines
Wed 9/247:00 amSFO - MYR
2 stops11h 09mAmerican Airlines
Deal found 8/13$302
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2112:18 pmMYR - SFO
1 stop10h 05mAmerican Airlines
Fri 10/2410:15 pmSFO - MYR
1 stop7h 45mAmerican Airlines
Deal found 8/14$318
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/252:20 pmMYR - SFO
1 stop9h 08mDelta
Fri 10/311:57 pmSFO - MYR
1 stop7h 13mDelta
Deal found 8/13$339
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/252:45 pmMYR - SFO
1 stop10h 06mAmerican Airlines
Fri 10/37:45 pmSFO - MYR
2 stops10h 48mAmerican Airlines
Deal found 8/14$344
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/226:10 pmMYR - SFO
1 stop7h 40mAmerican Airlines
Wed 11/2611:50 pmSFO - MYR
1 stop9h 07mAmerican Airlines
Deal found 8/14$357

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Myrtle Beach to San Francisco that are best for you.

Fly from

Myrtle Beach

Fly to

San Francisco

Route

Depart

Return

Price

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 10/1

2:20 pm-6:48 pm

1 stop7h 28m

San Francisco

Wed 10/8

11:58 am-11:59 pm

1 stop9h 01m

$283

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 10/8

6:00 am-11:51 am

1 stop8h 51m

San Francisco

Wed 10/22

10:15 pm-9:06 am

1 stop7h 51m

$283

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 9/9

4:45 pm-11:59 pm

1 stop10h 14m

San Francisco

Tue 9/16

10:45 pm-10:39 am

1 stop8h 54m

$283

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 9/17

5:53 pm-11:15 pm

1 stop8h 22m

San Francisco

Wed 9/24

10:00 am-9:09 pm

1 stop8h 09m

$283

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 10/1

12:23 pm-7:02 pm

2 stops9h 39m

San Francisco

Wed 10/8

7:04 am-6:45 pm

1 stop8h 41m

$288

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 9/2

8:48 pm-10:33 pm

2 stops28h 45m

$170

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Fri 9/5

7:17 pm-9:21 pm

2 stops29h 04m

$171

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Sun 9/28

4:20 pm-10:48 pm

1 stop9h 28m

$177

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Fri 9/5

6:15 am-11:30 am

1 stop8h 15m

$177

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Wed 10/15

4:33 pm-11:59 pm

1 stop10h 26m

$192

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 13 results
1
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Best time to book a flight from Myrtle Beach to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to San Francisco

What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $276). Flying from Myrtle Beach to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to SFO?

Find hourly flight availability from Myrtle Beach to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

One of the essential ways to save on airfare from Myrtle Beach to San Francisco is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight at noon could potentially save you up to 8% on airfare.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 14, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Myrtle Beach to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Myrtle Beach to San Francisco round-trip?

    Currently priced at $250, Delta will fly you from Myrtle Beach to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $312. You may be able to fly from Myrtle Beach to San Francisco for 43% less than the average price by searching for these airlines.

  • Can I find deals for flights from Myrtle Beach to San Francisco that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to San Francisco.

  • Can I find deals for business class flights from Myrtle Beach to San Francisco?

    Yes. Cheapflights offers flight deals from Myrtle Beach to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to San Francisco (average of $276). Flying from Myrtle Beach to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Mountain View
Turlock
Santa Clara
Hollister
Antioch
Watsonville
Manteca
Sunnyvale
Newark
Milpitas
Campbell
Foster City
San Leandro
Burlingame
Redwood City
Vallejo

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Myrtle Beach to San Francisco

Discover the top 2 airlines that operate flights from Myrtle Beach to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$250Average$414FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$312Average$453FlexibilityNo cancel feeOn-time71%

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