$179+ Cheap flights from La Crosse to San Francisco (LSE - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/12. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SFO
Apr 22 — Apr 291
Round-trip
1 adult, Economy
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Find cheap flights from La Crosse to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to San Francisco
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Best
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One-way
Cheapest flights from La Crosse to San FranciscoExplore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.
Explore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:29 pm
LSE
- SFO
1 stop7h 15m
American Airlines
Tue 4/1411:52 am
SFO
- LSE
1 stop10h 02m
American Airlines
Deal found 3/20![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:40 am
LSE
- SFO
2 stops11h 19m
American Airlines
Wed 4/227:53 pm
SFO
- LSE
2 stops11h 42m
American Airlines
Deal found 3/23![American Airlines logo]()
$394
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:51 am
LSE
- SFO
2 stops31h 50m
Multiple Airlines
Sun 8/307:12 pm
SFO
- LSE
1 stop15h 54m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$398
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:09 am
LSE
- SFO
1 stop9h 47m
American Airlines
Wed 4/811:28 pm
SFO
- LSE
1 stop8h 07m
American Airlines
Deal found 3/19![American Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:15 am
LSE
- SFO
1 stop6h 54m
United Airlines
Sun 8/3010:35 pm
SFO
- LSE
1 stop8h 21m
United Airlines
Deal found 3/21![United Airlines logo]()
$428
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:40 am
LSE
- SFO
2 stops13h 59m
American Airlines
Tue 4/1410:06 am
SFO
- LSE
2 stops11h 48m
American Airlines
Deal found 3/20![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:40 am
LSE
- SFO
1 stop8h 58m
American Airlines
Sat 4/252:57 pm
SFO
- LSE
1 stop6h 57m
American Airlines
Deal found 3/18![American Airlines logo]()
$463
Best flights from La Crosse to San FranciscoDiscover carefully curated flight deals from La Crosse to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 23, 2026.
Discover carefully curated flight deals from La Crosse to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 23, 2026.
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:29 pm
LSE
- SFO
1 stop7h 15m
American Airlines
Tue 4/1411:52 am
SFO
- LSE
1 stop10h 02m
American Airlines
Deal found 3/20![American Airlines logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2710:51 am
LSE
- SFO
2 stops31h 50m
Multiple Airlines
Sun 8/307:12 pm
SFO
- LSE
1 stop15h 54m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:15 am
LSE
- SFO
1 stop6h 54m
United Airlines
Sun 8/3010:35 pm
SFO
- LSE
1 stop8h 21m
United Airlines
Deal found 3/21![United Airlines logo]()
$428
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:37 pm
LSE
- SFO
1 stop7h 22m
American Airlines
Wed 4/2211:28 pm
SFO
- LSE
1 stop8h 07m
American Airlines
Deal found 3/23![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:09 am
LSE
- SFO
1 stop9h 47m
American Airlines
Wed 4/811:28 pm
SFO
- LSE
1 stop8h 07m
American Airlines
Deal found 3/19![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:29 pm
LSE
- SFO
1 stop7h 15m
American Airlines
Fri 4/102:57 pm
SFO
- LSE
1 stop6h 57m
American Airlines
Deal found 3/22![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:40 am
LSE
- SFO
1 stop8h 58m
American Airlines
Sat 4/252:57 pm
SFO
- LSE
1 stop6h 57m
American Airlines
Deal found 3/18![American Airlines logo]()
$463
Last-minute flights from La Crosse to San FranciscoDiscover last-minute flight deals from La Crosse to San Francisco. Data last updated March 23, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to San Francisco. Data last updated March 23, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:09 am
LSE
- SFO
1 stop9h 47m
American Airlines
Wed 4/811:28 pm
SFO
- LSE
1 stop8h 07m
American Airlines
Deal found 3/19![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:29 pm
LSE
- SFO
1 stop7h 15m
American Airlines
Tue 4/1411:52 am
SFO
- LSE
1 stop10h 02m
American Airlines
Deal found 3/20![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:29 pm
LSE
- SFO
1 stop7h 15m
American Airlines
Fri 4/1012:06 pm
SFO
- LSE
2 stops9h 48m
American Airlines
Deal found 3/22![American Airlines logo]()
$494
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:40 am
LSE
- SFO
2 stops13h 59m
American Airlines
Tue 4/1410:06 am
SFO
- LSE
2 stops11h 48m
American Airlines
Deal found 3/20![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:40 am
LSE
- SFO
2 stops11h 19m
American Airlines
Wed 4/227:53 pm
SFO
- LSE
2 stops11h 42m
American Airlines
Deal found 3/23![American Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:40 am
LSE
- SFO
1 stop8h 58m
American Airlines
Sat 4/252:57 pm
SFO
- LSE
1 stop6h 57m
American Airlines
Deal found 3/18![American Airlines logo]()
$463
One-way flights from La Crosse to San FranciscoSearch for one-way flight options from La Crosse to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 23, 2026.
Search for one-way flight options from La Crosse to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 23, 2026.
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:26 pm
LSE
- SFO
1 stop7h 24m
United Airlines
Deal found 3/18![United Airlines logo]()
$179
This American Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:40 am
LSE
- SFO
2 stops13h 59m
American Airlines
Deal found 3/18![American Airlines logo]()
$290
Find flight deals from La Crosse to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $383 (American Airlines) |
One-way from | $179 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from La Crosse to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Mon 4/6
6:29 pm-11:44 pm
1 stop7h 15m
San Francisco
Tue 4/14
11:52 am-11:54 pm
1 stop10h 02m
$383
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Wed 4/8
6:37 pm-11:59 pm
1 stop7h 22m
San Francisco
Wed 4/22
11:28 pm-9:35 am
1 stop8h 07m
$383
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Thu 8/27
10:51 am-4:41 pm
2 stops31h 50m
San Francisco
Sun 8/30
7:12 pm-1:06 pm
1 stop15h 54m
$398
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Sat 4/4
5:09 am-12:56 pm
1 stop9h 47m
San Francisco
Wed 4/8
11:28 pm-9:35 am
1 stop8h 07m
$408
Quickest round-trip
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Mon 4/6
6:29 pm-11:44 pm
1 stop7h 15m
San Francisco
Fri 4/10
2:57 pm-11:54 pm
1 stop6h 57m
$408
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Thu 8/27
8:15 am-1:09 pm
1 stop6h 54m
San Francisco
Sun 8/30
10:35 pm-8:56 am
1 stop8h 21m
$428
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Sun 4/19
5:40 am-12:38 pm
1 stop8h 58m
San Francisco
Sat 4/25
2:57 pm-11:54 pm
1 stop6h 57m
$463
Cheapest one-way
Quickest one-way
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Tue 5/12
7:26 pm-12:50 am
1 stop7h 24m
$179
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Tue 5/12
5:40 am-5:39 pm
2 stops13h 59m
$290
Sorted by cheapest first
Compare providers for flights from La Crosse to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from La Crosse to San Francisco in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on La Crosse-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from La Crosse with our price prediction graph.
LSE-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 23, 2026.
Read through reviews of airlines operating flights from La Crosse to San Francisco, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Overall
7.1
Crew
7.9
Entertainment
6.9
Food
6.4
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Comfort
7.2
Overall
7.1
Crew
7.9
Entertainment
6.9
Food
6.4
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from La Crosse to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Livermore
Roseville
Watsonville
Rancho Cordova
San Bruno
San Ramon
Sunnyvale
Vacaville
San Carlos
Redwood City
Turlock
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Rohnert Park
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La Crosse and San Francisco flights
Browse other La Crosse and San Francisco flight options. Last updated on March 23, 2026.
Other flights from La Crosse
Browse through other flights departing from La Crosse. Flights are based on user searches made on Cheapflights and were last updated on March 23, 2026.
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Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 23, 2026.
Top airline flying from La Crosse to San Francisco
Discover the top airline that operate flights from La Crosse to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$454 | Average$523 | FlexibilityNo cancel fee | On-time71% |