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$484+ Cheap flights from La Crosse to San Francisco (LSE - SFO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SFO
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from La Crosse to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$484
(American Airlines)
From La Crosse to San Francisco
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Find flight deals from La Crosse to San Francisco

Cheapest flights from La Crosse to San Francisco
Explore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/16:00 amLSE - SFO
1 stop7h 15mAmerican Airlines
Sun 10/52:22 pmSFO - LSE
1 stop6h 55mAmerican Airlines
Deal found 9/16$533
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:00 amLSE - SFO
1 stop7h 26mAmerican Airlines
Sat 12/136:00 amSFO - LSE
1 stop9h 32mAmerican Airlines
Deal found 9/15$544
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:00 amLSE - SFO
1 stop8h 31mAmerican Airlines
Mon 10/62:10 pmSFO - LSE
1 stop7h 16mAmerican Airlines
Deal found 9/17$580

Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from La Crosse to San Francisco that are best for you.

Fly from

La Crosse

Fly to

San Francisco

Route

Depart

Return

Price

La CrosseSan Francisco

LSE - SFO

LSESFO

La Crosse

Wed 1/21

6:06 am-10:59 am

1 stop6h 53m

San Francisco

Sun 1/25

1:22 pm-10:32 pm

1 stop7h 10m

$484

La CrosseSan Francisco

LSE - SFO

LSESFO

La Crosse

Thu 2/26

6:26 pm-11:28 pm

1 stop7h 02m

San Francisco

Mon 3/2

11:45 pm-2:18 pm

2 stops12h 33m

$520

La CrosseSan Francisco

LSE - SFO

LSESFO

La Crosse

Wed 10/1

6:00 am-11:15 am

1 stop7h 15m

San Francisco

Sun 10/5

2:22 pm-11:17 pm

1 stop6h 55m

$533

La CrosseSan Francisco

LSE - SFO

LSESFO

La Crosse

Wed 12/10

6:00 am-11:26 am

1 stop7h 26m

San Francisco

Sat 12/13

6:00 am-5:32 pm

1 stop9h 32m

$544

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Best time to book a flight from La Crosse to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from La Crosse to San Francisco, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Entertainment

6.9

Food

6.4

Overall

7.2

Crew

8.0

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Entertainment

6.9

Food

6.4

Overall

7.2

Crew

8.0

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from La Crosse to San Francisco?

    Departing from La Crosse to San Francisco will take you 6h 53m. There are 1673 mi between La Crosse and San Francisco.

  • What is the cheapest airline to fly from La Crosse to San Francisco round-trip?

    Cheapflights users have booked flights from La Crosse to San Francisco round-trip from $454.

  • Can I find deals for flights from La Crosse to San Francisco that include hotel bookings?

    Yes. In addition to deals on La Crosse to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to San Francisco.

  • Can I find deals for business class flights from La Crosse to San Francisco?

    Yes. Cheapflights offers flight deals from La Crosse to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from La Crosse to San Francisco (average of $276). Flying from La Crosse to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Hollister
Vacaville
Foster City
Union City
Vallejo
Burlingame
Redwood City
San Mateo
San Leandro
Lathrop

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Top airline flying from La Crosse to San Francisco

Discover the top airline that operate flights from La Crosse to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$454Average$507FlexibilityNo cancel feeOn-time71%

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