$134+ Cheap flights from La Crosse to San Francisco (LSE - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SFO
Mar 12 — Mar 191
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from La Crosse to San Francisco
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Cheapest flights from La Crosse to San FranciscoExplore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 10, 2026.
Explore the most affordable flight options available from La Crosse to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 10, 2026.
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:15 pm
LSE
- SFO
1 stop7h 27m
United Airlines
Mon 6/110:45 pm
SFO
- LSE
1 stop8h 11m
United Airlines
Deal found 2/10![United Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:37 pm
LSE
- SFO
1 stop20h 01m
American Airlines
Wed 4/157:21 am
SFO
- LSE
1 stop14h 33m
American Airlines
Deal found 2/7![American Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:37 pm
LSE
- SFO
1 stop17h 15m
American Airlines
Fri 5/811:52 am
SFO
- LSE
1 stop19h 43m
American Airlines
Deal found 2/8![American Airlines logo]()
$422
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:40 am
LSE
- SFO
2 stops13h 59m
American Airlines
Tue 4/1411:52 am
SFO
- LSE
1 stop19h 43m
American Airlines
Deal found 2/7![American Airlines logo]()
$437
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:09 am
LSE
- SFO
1 stop11h 14m
American Airlines
Sat 3/1411:29 pm
SFO
- LSE
1 stop9h 33m
American Airlines
Deal found 2/9![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:29 pm
LSE
- SFO
1 stop17h 11m
American Airlines
Mon 3/165:34 pm
SFO
- LSE
1 stop13h 44m
American Airlines
Deal found 2/7![American Airlines logo]()
$458
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:15 pm
LSE
- SFO
2 stops13h 20m
United Airlines
Mon 6/111:30 pm
SFO
- LSE
1 stop7h 26m
United Airlines
Deal found 2/10![United Airlines logo]()
$476
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:37 pm
LSE
- SFO
1 stop7h 22m
American Airlines
Sun 5/248:08 pm
SFO
- LSE
2 stops12h 53m
American Airlines
Deal found 2/7![American Airlines logo]()
$490
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:00 pm
LSE
- SFO
1 stop7h 35m
United Airlines
Sun 5/243:01 pm
SFO
- LSE
1 stop7h 14m
United Airlines
Deal found 2/7![United Airlines logo]()
$493
Best flights from La Crosse to San FranciscoDiscover carefully curated flight deals from La Crosse to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 10, 2026.
Discover carefully curated flight deals from La Crosse to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 10, 2026.
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:15 pm
LSE
- SFO
1 stop7h 27m
United Airlines
Mon 6/110:45 pm
SFO
- LSE
1 stop8h 11m
United Airlines
Deal found 2/10![United Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:40 am
LSE
- SFO
2 stops13h 59m
American Airlines
Tue 4/1411:52 am
SFO
- LSE
1 stop19h 43m
American Airlines
Deal found 2/7![American Airlines logo]()
$437
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:15 pm
LSE
- SFO
1 stop7h 27m
United Airlines
Mon 6/110:45 pm
SFO
- LSE
1 stop8h 11m
United Airlines
Deal found 2/10![United Airlines logo]()
$298
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:40 am
LSE
- SFO
2 stops13h 59m
American Airlines
Wed 4/157:21 am
SFO
- LSE
1 stop14h 33m
American Airlines
Deal found 2/7![American Airlines logo]()
$437
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:09 am
LSE
- SFO
1 stop11h 14m
American Airlines
Sat 3/1411:29 pm
SFO
- LSE
1 stop9h 33m
American Airlines
Deal found 2/9![American Airlines logo]()
$446
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:00 pm
LSE
- SFO
1 stop7h 35m
United Airlines
Sun 5/243:01 pm
SFO
- LSE
1 stop7h 14m
United Airlines
Deal found 2/7![United Airlines logo]()
$493
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:29 pm
LSE
- SFO
1 stop17h 11m
American Airlines
Mon 3/165:34 pm
SFO
- LSE
1 stop13h 44m
American Airlines
Deal found 2/8![American Airlines logo]()
$458
Last-minute flights from La Crosse to San FranciscoDiscover last-minute flight deals from La Crosse to San Francisco. Data last updated February 10, 2026 and is based on user searches.
Discover last-minute flight deals from La Crosse to San Francisco. Data last updated February 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/215:20 am
LSE
- SFO
2 stops10h 17m
American Airlines
Tue 2/243:13 pm
SFO
- LSE
1 stop6h 23m
American Airlines
Deal found 2/7![American Airlines logo]()
$605
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:29 pm
LSE
- SFO
1 stop7h 18m
American Airlines
Sat 2/283:13 pm
SFO
- LSE
1 stop6h 23m
American Airlines
Deal found 2/9![American Airlines logo]()
$526
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:09 am
LSE
- SFO
1 stop11h 14m
American Airlines
Sat 3/1411:29 pm
SFO
- LSE
1 stop9h 33m
American Airlines
Deal found 2/9![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:29 pm
LSE
- SFO
1 stop17h 11m
American Airlines
Mon 3/165:34 pm
SFO
- LSE
1 stop13h 44m
American Airlines
Deal found 2/7![American Airlines logo]()
$458
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:29 pm
LSE
- SFO
1 stop7h 15m
American Airlines
Mon 3/3011:29 pm
SFO
- LSE
1 stop7h 49m
American Airlines
Deal found 2/7![American Airlines logo]()
$514
One-way flights from La Crosse to San FranciscoSearch for one-way flight options from La Crosse to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 10, 2026.
Search for one-way flight options from La Crosse to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:43 pm
LSE
- SFO
2 stops34h 51m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2011:43 am
LSE
- SFO
2 stops22h 20m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$258
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:37 pm
LSE
- SFO
1 stop20h 01m
American Airlines
Deal found 2/8![American Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2611:34 am
LSE
- SFO
1 stop12h 58m
American Airlines
Deal found 2/9![American Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:37 pm
LSE
- SFO
1 stop18h 25m
American Airlines
Deal found 2/8![American Airlines logo]()
$390
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:29 pm
LSE
- SFO
1 stop7h 18m
American Airlines
Deal found 2/9![American Airlines logo]()
$530
Find flight deals from La Crosse to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $374 (American Airlines) |
One-way from | $134 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from La Crosse to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 10, 2026.
Use the filters below to find and compare flights from La Crosse to San Francisco that are best for you.
Fly from
La Crosse
Fly to
San Francisco
Route
Depart
Return
Price
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Thu 5/28
8:15 pm-1:42 am
1 stop7h 27m
San Francisco
Mon 6/1
10:45 pm-8:56 am
1 stop8h 11m
$298
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Fri 5/29
8:15 pm-1:42 am
1 stop7h 27m
San Francisco
Mon 6/1
10:45 pm-8:56 am
1 stop8h 11m
$298
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Tue 4/7
5:40 am-5:39 pm
2 stops13h 59m
San Francisco
Tue 4/14
11:52 am-9:35 am
1 stop19h 43m
$437
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Tue 4/7
5:40 am-5:39 pm
2 stops13h 59m
San Francisco
Wed 4/15
7:21 am-11:54 pm
1 stop14h 33m
$437
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Tue 3/10
5:09 am-2:23 pm
1 stop11h 14m
San Francisco
Sat 3/14
11:29 pm-11:02 am
1 stop9h 33m
$446
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Fri 3/13
6:29 pm-9:40 am
1 stop17h 11m
San Francisco
Mon 3/16
5:34 pm-9:18 am
1 stop13h 44m
$458
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Wed 5/20
8:00 pm-1:35 am
1 stop7h 35m
San Francisco
Sun 5/24
3:01 pm-12:15 am
1 stop7h 14m
$493
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Mon 4/13
12:43 pm-9:34 pm
2 stops34h 51m
$134
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Fri 2/20
11:43 am-8:03 am
2 stops22h 20m
$258
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Mon 4/13
6:37 pm-12:38 pm
1 stop20h 01m
$307
Showing 1-10 of 13 results
Compare providers for flights from La Crosse to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from La Crosse to San Francisco in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on La Crosse-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on La Crosse-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from La Crosse to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from La Crosse with our price prediction graph.
LSE-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated February 10, 2026.
Read through reviews of airlines operating flights from La Crosse to San Francisco, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.0
Food
6.4
Overall
7.2
Comfort
7.2
Entertainment
6.9
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2024
LHR - SAN
Crew
8.0
Food
6.4
Overall
7.2
Comfort
7.2
Entertainment
6.9
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentAnonymous,Jan 2024
LHR - SAN
Related info for your journey
Find useful and relevant information for your journey from La Crosse to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSanta Cruz
South San Francisco
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Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
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La Crosse and San Francisco flights
Browse other La Crosse and San Francisco flight options. Last updated on February 10, 2026.
Other flights from La Crosse
Browse through other flights departing from La Crosse. Flights are based on user searches made on Cheapflights and were last updated on February 10, 2026.
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Other flights to San Francisco
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Top airline flying from La Crosse to San Francisco
Discover the top airline that operate flights from La Crosse to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$454 | Average$523 | FlexibilityNo cancel fee | On-time71% |