$89+ Cheap flights from Iowa to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Mar 15 — Mar 221
1 adult, Economy
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Find cheap flights from Iowa to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Iowa to San Francisco
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Cheapest flights from Iowa to San FranciscoExplore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
Explore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 13, 2026.
This Priceline deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:00 pm
OMA
- SFO
1 stop9h 28m
Frontier
Wed 3/47:35 am
SFO
- OMA
1 stop6h 30m
Frontier
Deal found 2/10![Frontier logo]()
$159
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/11:43 pm
OMA
- SFO
1 stop20h 20m
Frontier
Wed 3/47:35 am
SFO
- OMA
1 stop6h 30m
Frontier
Deal found 2/11![Frontier logo]()
$170
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/231:59 pm
OMA
- SFO
1 stop9h 40m
Frontier
Wed 3/47:35 am
SFO
- OMA
1 stop6h 30m
Frontier
Deal found 2/10![Frontier logo]()
$180
This Southwest deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:35 pm
OMA
- SFO
1 stop8h 05m
Southwest
Tue 3/311:35 pm
SFO
- OMA
1 stop8h 15m
Southwest
Deal found 2/12![Southwest logo]()
$187
This Expedia deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:19 pm
OMA
- SFO
1 stop14h 44m
Frontier
Sun 3/111:09 pm
SFO
- OMA
1 stop11h 55m
Frontier
Deal found 2/10![Frontier logo]()
$190
This Frontier deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- SFO
1 stop14h 36m
Frontier
Tue 3/109:04 pm
SFO
- DSM
1 stop20h 12m
Frontier
Deal found 2/13![Frontier logo]()
$190
This Southwest deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/93:35 pm
OMA
- SFO
2 stops8h 35m
Southwest
Mon 4/135:15 am
SFO
- OMA
1 stop9h 50m
Southwest
Deal found 2/13![Southwest logo]()
$198
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:35 pm
OMA
- SFO
2 stops8h 35m
Southwest
Tue 4/141:45 pm
SFO
- OMA
1 stop5h 50m
Southwest
Deal found 2/11![Southwest logo]()
$202
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:59 pm
OMA
- SFO
1 stop9h 40m
Frontier
Mon 3/96:00 am
SFO
- OMA
1 stop12h 18m
Frontier
Deal found 2/10![Frontier logo]()
$204
This Expedia deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:59 pm
DSM
- SFO
1 stop6h 29m
Frontier
Mon 3/96:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Deal found 2/12![Frontier logo]()
$204
This Expedia deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:19 pm
OMA
- SFO
1 stop28h 42m
Frontier
Thu 2/2610:46 pm
SFO
- OMA
1 stop12h 18m
Frontier
Deal found 2/11![Frontier logo]()
$211
This Priceline deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:17 pm
DSM
- SFO
1 stop7h 11m
Frontier
Thu 2/268:48 am
SFO
- DSM
1 stop7h 54m
Frontier
Deal found 2/11![Frontier logo]()
$211
Best flights from Iowa to San FranciscoDiscover carefully curated flight deals from Iowa to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
Discover carefully curated flight deals from Iowa to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 13, 2026.
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:35 pm
OMA
- SFO
2 stops8h 35m
Southwest
Tue 4/141:45 pm
SFO
- OMA
1 stop5h 50m
Southwest
Deal found 2/11![Southwest logo]()
$202
This Expedia deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:19 pm
OMA
- SFO
1 stop28h 42m
Frontier
Wed 3/47:35 am
SFO
- OMA
1 stop6h 30m
Frontier
Deal found 2/12![Frontier logo]()
$211
This Alaska Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:00 am
OMA
- SFO
1 stop9h 21m
Alaska Airlines
Tue 5/52:00 pm
SFO
- OMA
1 stop22h 03m
Alaska Airlines
Deal found 2/13![Alaska Airlines logo]()
$229
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:15 am
OMA
- SFO
1 stop8h 03m
United Airlines
Sat 5/164:15 pm
SFO
- OMA
Nonstop3h 44m
United Airlines
Deal found 2/11![United Airlines logo]()
$259
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:00 pm
MLI
- SFO
1 stop9h 15m
Delta
Mon 7/610:30 pm
SFO
- MLI
1 stop9h 56m
Delta
Deal found 2/13![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:25 pm
CID
- SFO
1 stop7h 23m
American Airlines
Mon 3/3011:29 pm
SFO
- CID
1 stop7h 44m
American Airlines
Deal found 2/12![American Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/99:18 pm
MLI
- SFO
2 stops26h 20m
Multiple Airlines
Sat 3/147:32 pm
SFO
- MLI
1 stop13h 55m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$340
This Expedia deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/611:54 am
OMA
- SFO
1 stop9h 20m
Frontier
Sun 3/810:40 pm
SFO
- OMA
1 stop9h 54m
Frontier
Deal found 2/13![Frontier logo]()
$250
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:45 am
OMA
- SFO
1 stop6h 05m
Southwest
Sat 5/163:05 pm
SFO
- OMA
1 stop5h 30m
Southwest
Deal found 2/11![Southwest logo]()
$263
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:10 pm
OMA
- SFO
1 stop9h 09m
United Airlines
Wed 4/295:00 am
SFO
- OMA
1 stop5h 47m
United Airlines
Deal found 2/11![United Airlines logo]()
$269
This Expedia deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:13 pm
CID
- SFO
1 stop10h 15m
Frontier
Sun 3/296:00 am
SFO
- CID
1 stop5h 38m
Frontier
Deal found 2/13![Frontier logo]()
$264
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:05 pm
OMA
- SFO
2 stops7h 10m
Southwest
Wed 4/296:20 am
SFO
- OMA
1 stop7h 20m
Southwest
Deal found 2/11![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/54:22 pm
CID
- SFO
1 stop6h 29m
Delta
Sun 5/106:00 am
SFO
- CID
1 stop7h 38m
Delta
Deal found 2/12![Delta logo]()
$309
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/28:59 pm
OMA
- SFO
1 stop5h 24m
Frontier
Sun 4/510:23 pm
SFO
- OMA
1 stop12h 46m
Frontier
Deal found 2/11![Frontier logo]()
$270
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:15 pm
LSE
- SFO
1 stop7h 27m
United Airlines
Mon 6/110:45 pm
SFO
- LSE
1 stop8h 11m
United Airlines
Deal found 2/10![United Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/93:35 pm
OMA
- SFO
2 stops8h 35m
Southwest
Mon 4/135:15 am
SFO
- OMA
1 stop9h 50m
Southwest
Deal found 2/12![Southwest logo]()
$280
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/24:22 pm
CID
- SFO
1 stop6h 29m
Delta
Sat 5/96:00 am
SFO
- CID
1 stop7h 38m
Delta
Deal found 2/12![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:15 pm
LSE
- SFO
1 stop7h 27m
United Airlines
Mon 6/110:45 pm
SFO
- LSE
1 stop8h 11m
United Airlines
Deal found 2/10![United Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:35 pm
OMA
- SFO
2 stops8h 35m
Southwest
Mon 4/135:15 am
SFO
- OMA
1 stop9h 50m
Southwest
Deal found 2/12![Southwest logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1010:11 pm
DSM
- SFO
2 stops23h 30m
Multiple Airlines
Mon 4/136:00 am
SFO
- DSM
1 stop11h 14m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/112:00 pm
DSM
- SFO
1 stop13h 59m
American Airlines
Tue 5/511:28 pm
SFO
- DSM
1 stop10h 02m
American Airlines
Deal found 2/13![American Airlines logo]()
$393
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:16 pm
MLI
- SFO
1 stop9h 30m
Delta
Mon 5/2511:59 pm
SFO
- MLI
1 stop8h 16m
Delta
Deal found 2/12![Delta logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:21 pm
DSM
- SFO
2 stops24h 16m
Frontier
Mon 4/66:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 2/13![Frontier logo]()
$306
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:22 pm
MLI
- SFO
1 stop8h 02m
United Airlines
Mon 3/911:59 pm
SFO
- MLI
1 stop8h 10m
United Airlines
Deal found 2/11![United Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/49:31 pm
DSM
- SFO
1 stop12h 12m
Multiple Airlines
Mon 6/88:43 am
SFO
- DSM
1 stop10h 23m
Multiple Airlines
Deal found 2/12![Multiple Airlines logo]()
$387
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:10 pm
OMA
- SFO
1 stop5h 20m
Southwest
Tue 3/311:30 am
SFO
- OMA
2 stops8h 50m
Southwest
Deal found 2/10![Southwest logo]()
$304
This American Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/55:00 am
DSM
- SFO
1 stop7h 41m
American Airlines
Wed 4/86:00 am
SFO
- DSM
1 stop11h 33m
American Airlines
Deal found 2/13![American Airlines logo]()
$405
This United Airlines deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/192:31 pm
MLI
- SFO
1 stop6h 53m
United Airlines
Mon 7/610:45 pm
SFO
- MLI
1 stop9h 14m
United Airlines
Deal found 2/13![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:16 pm
MLI
- SFO
2 stops17h 05m
Delta
Thu 5/2811:59 pm
SFO
- MLI
1 stop8h 16m
Delta
Deal found 2/12![Delta logo]()
$347
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:25 pm
CID
- SFO
1 stop7h 17m
United Airlines
Sun 5/2412:50 am
SFO
- CID
1 stop7h 43m
United Airlines
Deal found 2/11![United Airlines logo]()
$309
Last-minute flights from Iowa to San FranciscoDiscover last-minute flight deals from Iowa to San Francisco. Data last updated February 13, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to San Francisco. Data last updated February 13, 2026 and is based on user searches.
This Priceline deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:17 pm
DSM
- SFO
1 stop7h 11m
Frontier
Thu 2/268:48 am
SFO
- DSM
1 stop7h 54m
Frontier
Deal found 2/11![Frontier logo]()
$211
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/231:59 pm
OMA
- SFO
1 stop9h 40m
Frontier
Wed 3/47:35 am
SFO
- OMA
1 stop6h 30m
Frontier
Deal found 2/10![Frontier logo]()
$180
This Expedia deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:19 pm
OMA
- SFO
1 stop28h 42m
Frontier
Thu 2/2610:46 pm
SFO
- OMA
1 stop12h 18m
Frontier
Deal found 2/11![Frontier logo]()
$211
This Priceline deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:00 pm
OMA
- SFO
1 stop9h 28m
Frontier
Wed 3/47:35 am
SFO
- OMA
1 stop6h 30m
Frontier
Deal found 2/10![Frontier logo]()
$159
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/268:07 pm
CID
- SFO
1 stop6h 21m
Frontier
Mon 3/26:15 am
SFO
- CID
1 stop10h 57m
Frontier
Deal found 2/11![Frontier logo]()
$211
This Expedia deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:19 pm
OMA
- SFO
1 stop14h 44m
Frontier
Sun 3/111:09 pm
SFO
- OMA
1 stop11h 55m
Frontier
Deal found 2/10![Frontier logo]()
$190
This Expedia deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:59 pm
DSM
- SFO
1 stop6h 29m
Frontier
Mon 3/96:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Deal found 2/12![Frontier logo]()
$204
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/11:43 pm
OMA
- SFO
1 stop20h 20m
Frontier
Wed 3/47:35 am
SFO
- OMA
1 stop6h 30m
Frontier
Deal found 2/11![Frontier logo]()
$170
This Frontier deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- SFO
1 stop14h 36m
Frontier
Tue 3/109:04 pm
SFO
- DSM
1 stop20h 12m
Frontier
Deal found 2/13![Frontier logo]()
$190
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:59 pm
OMA
- SFO
1 stop9h 40m
Frontier
Mon 3/96:00 am
SFO
- OMA
1 stop12h 18m
Frontier
Deal found 2/10![Frontier logo]()
$204
This Southwest deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:35 pm
OMA
- SFO
1 stop8h 05m
Southwest
Tue 3/311:35 pm
SFO
- OMA
1 stop8h 15m
Southwest
Deal found 2/12![Southwest logo]()
$187
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Mon 4/66:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 2/10![Frontier logo]()
$220
One-way flights from Iowa to San FranciscoSearch for one-way flight options from Iowa to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
Search for one-way flight options from Iowa to San Francisco. Find affordable one-way fares based on user searches. Data last updated February 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/308:59 pm
OMA
- SFO
1 stop29h 23m
Frontier
Deal found 2/10![Frontier logo]()
$89
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/277:19 pm
OMA
- SFO
1 stop7h 09m
Frontier
Deal found 2/11![Frontier logo]()
$95
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:14 pm
DSM
- SFO
1 stop6h 09m
Frontier
Deal found 2/10![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/412:34 pm
OMA
- SFO
1 stop30h 18m
Multiple Airlines
Deal found 2/13![Multiple Airlines logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:59 pm
OMA
- SFO
2 stops21h 53m
Frontier
Deal found 2/11![Frontier logo]()
$97
This Southwest deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/109:05 pm
OMA
- SFO
1 stop5h 45m
Southwest
Deal found 2/13![Southwest logo]()
$99
This Frontier deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:00 pm
OMA
- SFO
1 stop9h 28m
Frontier
Deal found 2/10![Frontier logo]()
$101
This Expedia deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- SFO
1 stop14h 36m
Frontier
Deal found 2/12![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:59 pm
OMA
- SFO
2 stops17h 53m
Frontier
Deal found 2/10![Frontier logo]()
$103
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:45 am
OMA
- SFO
2 stops8h 00m
Southwest
Deal found 2/11![Southwest logo]()
$104
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 2/11![Frontier logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:59 pm
OMA
- SFO
1 stop29h 23m
Frontier
Deal found 2/11![Frontier logo]()
$112
Find flight deals from Iowa to San Francisco
Keep the following information in mind while searching for Iowa to San Francisco flight deals. Data was last updated February 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $159 (Priceline) |
One-way from | $89 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $389 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Iowa to San Francisco that are best for you.
Fly from
Iowa
Fly to
San Francisco
Route
Depart
Return
Price
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Fri 4/10
3:35 pm-10:10 pm
2 stops8h 35m
San Francisco
Tue 4/14
1:45 pm-9:35 pm
1 stop5h 50m
$202
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Mon 2/23
7:19 pm-10:01 pm
1 stop28h 42m
San Francisco
Wed 3/4
7:35 am-4:05 pm
1 stop6h 30m
$211
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Wed 4/29
7:00 am-2:21 pm
1 stop9h 21m
San Francisco
Tue 5/5
2:00 pm-2:03 pm
1 stop22h 03m
$229
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Fri 3/6
11:54 am-7:14 pm
1 stop9h 20m
San Francisco
Sun 3/8
10:40 pm-10:34 am
1 stop9h 54m
$250
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Wed 5/13
6:15 am-12:18 pm
1 stop8h 03m
San Francisco
Sat 5/16
4:15 pm-9:59 pm
Nonstop3h 44m
$259
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Wed 5/13
5:45 am-9:50 am
1 stop6h 05m
San Francisco
Sat 5/16
3:05 pm-10:35 pm
1 stop5h 30m
$263
Cedar RapidsSan Francisco
CID - SFO
CIDSFO
Cedar Rapids
Thu 3/26
4:13 pm-12:28 am
1 stop10h 15m
San Francisco
Sun 3/29
6:00 am-1:38 pm
1 stop5h 38m
$264
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Tue 4/21
5:10 pm-12:19 am
1 stop9h 09m
San Francisco
Wed 4/29
5:00 am-12:47 pm
1 stop5h 47m
$269
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Thu 4/2
8:59 pm-12:23 am
1 stop5h 24m
San Francisco
Sun 4/5
10:23 pm-1:09 pm
1 stop12h 46m
$270
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Tue 4/21
6:05 pm-11:15 pm
2 stops7h 10m
San Francisco
Wed 4/29
6:20 am-3:40 pm
1 stop7h 20m
$274
Showing 1-10 of 57 results
Best time to book a flight from Iowa to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Iowa with our price prediction graph.
OMA-SFO
MLI-SFO
CID-SFO
LSE-SFO
DSM-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to San Francisco
USIA-SFO
OMA-SFO
MLI-SFO
CID-SFO
LSE-SFO
What is the cheapest month to book a flight from Iowa to San Francisco?
Currently, February is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $126). Flying from Iowa to San Francisco in September is currently the most expensive (average of $282). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Iowa to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSanta Cruz
South San Francisco
Santa Clara
Roseville
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Iowa to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to San Francisco by cabin class
Find flights from Iowa to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and San Francisco flights
Browse other Iowa and San Francisco flight options. Last updated on February 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 13, 2026.
Iowa to San Francisco flights
Consider these flights traveling from Iowa to San Francisco.
Top 5 airlines flying from Iowa to San Francisco
Discover the top 5 airlines that operate flights from Iowa to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$91 | Average$237 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$243 | Average$366 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$469 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$288 | Average$412 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$336 | Average$438 | FlexibilityNo cancel fee | On-time63% |