HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$91+ Cheap flights from Iowa to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Iowa to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Iowa to San Francisco

Cheapest flights from Iowa to San Francisco
Explore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Orbitz deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:29 pmDSM - SFO
1 stop13h 54mFrontier
Mon 12/296:24 amSFO - DSM
1 stop11h 20mFrontier
Deal found 12/15$233
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/243:15 pmDSM - SFO
1 stop6h 14mAmerican Airlines
Thu 1/16:00 amSFO - DSM
1 stop5h 57mAmerican Airlines
Deal found 12/16$327
This CheapOair deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:29 pmDSM - SFO
1 stop13h 54mFrontier
Sat 12/276:24 amSFO - DSM
1 stop11h 20mFrontier
Deal found 12/17$394
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:30 amOMA - SFO
Nonstop4h 17mUnited Airlines
Fri 1/25:00 amSFO - OMA
1 stop5h 49mUnited Airlines
Deal found 12/17$398
This CheapOair deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:29 pmDSM - SFO
1 stop20h 41mFrontier
Fri 1/26:24 amSFO - DSM
1 stop11h 20mFrontier
Deal found 12/16$398
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/222:35 pmMLI - SFO
2 stops10h 23mAmerican Airlines
Tue 12/3011:59 pmSFO - MLI
1 stop8h 40mAmerican Airlines
Deal found 12/16$409
This Frontier deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:48 pmCID - SFO
1 stop6h 36mFrontier
Thu 1/86:05 amSFO - CID
1 stop11h 15mFrontier
Deal found 12/16$412
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:25 amCID - SFO
1 stop6h 46mDelta
Wed 1/712:40 amSFO - CID
1 stop8h 51mDelta
Deal found 12/17$414
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:30 amOMA - SFO
Nonstop4h 17mUnited Airlines
Thu 12/2510:35 amSFO - OMA
Nonstop3h 34mUnited Airlines
Deal found 12/17$419
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:55 amCID - SFO
1 stop8h 06mAmerican Airlines
Wed 1/79:10 amSFO - CID
2 stops11h 05mAmerican Airlines
Deal found 12/16$419
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:30 amOMA - SFO
Nonstop4h 17mUnited Airlines
Fri 12/266:00 amSFO - OMA
1 stop9h 33mUnited Airlines
Deal found 12/16$429
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/243:15 pmDSM - SFO
1 stop6h 14mAmerican Airlines
Sun 1/410:49 pmSFO - DSM
1 stop7h 26mAmerican Airlines
Deal found 12/16$437

Find flight deals from Iowa to San Francisco

Keep the following information in mind while searching for Iowa to San Francisco flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$146
(Kiwi.com)

One-way from

$91
(Frontier)

Popular in

December

Cheapest in

September

Average price

$506
Provider with most accurate pricing for Des Moines-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-San Francisco flights.
Search Deals
From Iowa to San Francisco
Search Deals
One-way flight from Iowa to San Francisco
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Iowa to San Francisco that are best for you.

Fly from

Iowa

Fly to

San Francisco

Route

Depart

Return

Price

Cedar RapidsSan Francisco

CID - SFO

CIDSFO

Cedar Rapids

Thu 1/8

8:15 pm-12:24 am

1 stop6h 09m

San Francisco

Thu 1/15

6:15 am-7:13 pm

1 stop10h 58m

$182

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Wed 1/28

3:07 pm-11:03 pm

1 stop9h 56m

San Francisco

Sat 1/31

4:46 pm-2:11 pm

1 stop19h 25m

$228

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Mon 1/12

8:17 pm-11:07 pm

2 stops28h 50m

San Francisco

Fri 1/16

6:15 am-7:23 pm

1 stop11h 08m

$256

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Thu 1/15

7:28 am-9:45 am

Nonstop4h 17m

San Francisco

Sun 1/18

6:25 am-4:12 pm

1 stop7h 47m

$259

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sat 1/31

7:28 am-9:45 am

Nonstop4h 17m

San Francisco

Thu 2/5

6:25 am-4:12 pm

1 stop7h 47m

$259

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sat 2/14

4:00 pm-11:49 pm

1 stop9h 49m

San Francisco

Tue 2/17

3:00 pm-10:52 pm

1 stop5h 52m

$269

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sat 2/14

3:49 pm-10:04 pm

1 stop8h 15m

San Francisco

Tue 2/17

11:59 pm-8:56 am

1 stop6h 57m

$269

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sat 1/17

10:34 am-6:38 pm

1 stop10h 04m

San Francisco

Fri 1/23

3:00 pm-10:54 pm

1 stop5h 54m

$269

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sun 2/22

5:41 pm-11:47 pm

1 stop8h 06m

San Francisco

Sat 2/28

9:50 am-5:05 pm

1 stop5h 15m

$269

Cedar RapidsSan Francisco

CID - SFO

CIDSFO

Cedar Rapids

Sat 1/17

8:50 am-1:29 pm

1 stop6h 39m

San Francisco

Tue 1/27

6:45 am-4:52 pm

1 stop8h 07m

$275

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Iowa to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to San Francisco

What is the cheapest month to book a flight from Iowa to San Francisco?

Currently, December is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $144). Flying from Iowa to San Francisco in September is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SFO?

Find hourly flight availability from Iowa to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

When flying from Iowa to San Francisco, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 44% versus a flight in the morning.

What is the cheapest day to fly from Iowa to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Iowa to San Francisco. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Iowa to San Francisco flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Iowa to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Iowa?

    San Francisco (SFO), located 11.8 mi from the city center, is the airport you fly into when you book flights from Iowa to San Francisco.

  • How long is the flight from Iowa to San Francisco?

    A quick flight from Iowa to San Francisco can take about 4h 17m. Frontier provides one of the quickest options available for as low as $259. There are 1429 mi between Iowa and San Francisco. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Iowa to San Francisco one-way?

    $80 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $143 and $156, respectively.

  • What are the most popular routes from Iowa to San Francisco?

    The most popular route from Iowa to San Francisco is Omaha Eppley Airfield - San Francisco. You may also consider Des Moines - San Francisco or Cedar Rapids - San Francisco.

  • Can I find deals for flights from Iowa to San Francisco that include hotel bookings?

    Yes. In addition to deals on Iowa to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to San Francisco.

  • Can I find deals for business class flights from Iowa to San Francisco?

    Yes. Cheapflights offers flight deals from Iowa to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to San Francisco?

    Currently, December is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $144). Flying from Iowa to San Francisco in September is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Redwood City
Sunnyvale
Santa Clara
San Bruno
Daly City
San Carlos
Vallejo
Hollister
San Ramon
Foster City
Union City
Davis
Emeryville

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Los Angeles flights
John F Kennedy Intl to Las Vegas flights
Newark to Las Vegas flights
Newark to Los Angeles flights
Dallas/Fort Worth to Las Vegas flights
O'Hare Intl to Las Vegas flights
Seattle to Los Angeles flights
San Francisco to Las Vegas flights
Seattle to Las Vegas flights
John F Kennedy Intl to San Francisco flights
O'Hare Intl to Los Angeles flights
Atlanta to Las Vegas flights
Dulles Intl to Las Vegas flights
Dallas/Fort Worth to Los Angeles flights
LaGuardia to Los Angeles flights
Los Angeles to Las Vegas flights
LaGuardia to Las Vegas flights
Boston to Los Angeles flights
Los Angeles to San Francisco flights
Dulles Intl to Los Angeles flights
Denver to Las Vegas flights
Hobby to Las Vegas flights
Reagan-National to Los Angeles flights
Newark to San Francisco flights
Boston to Las Vegas flights
Baltimore to Los Angeles flights
Reagan-National to Las Vegas flights
Dallas/Fort Worth to San Francisco flights
Burbank to Las Vegas flights
Baltimore to Las Vegas flights
Santa Ana to Las Vegas flights
San Francisco to Los Angeles flights
Seattle to San Diego flights
Minneapolis to Las Vegas flights
O'Hare Intl to San Francisco flights
Detroit to Las Vegas flights
San Jose to Las Vegas flights
Orlando to Las Vegas flights
Atlanta to Los Angeles flights
Seattle to Ontario flights
Hobby to Los Angeles flights
Ontario to San Francisco flights
George Bush Intcntl to Las Vegas flights
Philadelphia to Las Vegas flights
San Jose to Los Angeles flights
San Francisco to Ontario flights
John F Kennedy Intl to San Diego flights
Austin to Las Vegas flights
Midway to Los Angeles flights
Denver to Los Angeles flights

Top 5 airlines flying from Iowa to San Francisco

Discover the top 5 airlines that operate flights from Iowa to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$130Average$227FlexibilityNo cancel feeOn-time62%
DeltaCheapest$265Average$369FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$288Average$471FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$288Average$433FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$336Average$424FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.