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$65+ Cheap flights from Iowa to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Iowa to San Francisco

Keep the following information in mind while searching for Iowa to San Francisco flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$183
(Frontier)

One-way from

$65
(Priceline)

Popular in

March

Cheapest in

August

Average price

$445
Provider with most accurate pricing for Des Moines-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Des Moines-San Francisco flights.
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From Iowa to San Francisco
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One-way flight from Iowa to San Francisco
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Highest demand for flights based on searches. 7% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Iowa to San Francisco

Cheapest flights from Iowa to San Francisco
Explore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Frontier deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:58 pmDSM - SFO
1 stop6h 26mFrontier
Thu 12/114:07 pmSFO - DSM
1 stop24h 56mFrontier
Deal found 10/28$183
This Priceline deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/711:29 amOMA - SFO
1 stop11h 42mFrontier
Sun 11/910:23 pmSFO - OMA
1 stop10h 11mFrontier
Deal found 10/28$194
This Frontier deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:26 pmCID - SFO
1 stop5h 48mFrontier
Mon 11/176:34 amSFO - CID
1 stop9h 47mFrontier
Deal found 10/29$206
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:58 pmDSM - SFO
1 stop6h 26mFrontier
Mon 12/158:48 amSFO - DSM
1 stop8h 15mFrontier
Deal found 10/27$208
This Frontier deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:51 pmOMA - SFO
1 stop5h 23mFrontier
Mon 11/176:34 amSFO - OMA
1 stop11h 32mFrontier
Deal found 10/29$213
This Booking.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:24 pmOMA - SFO
1 stop19h 29mFrontier
Sun 12/1411:33 pmSFO - OMA
1 stop13h 55mFrontier
Deal found 10/29$214
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/142:18 pmOMA - SFO
1 stop19h 35mMultiple Airlines
Wed 12/1710:10 pmSFO - OMA
2 stops36h 34mMultiple Airlines
Deal found 10/30$227
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:35 pmDSM - SFO
2 stops31h 55mMultiple Airlines
Thu 1/86:00 amSFO - DSM
1 stop7h 40mMultiple Airlines
Deal found 10/30$239
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/243:48 pmDSM - SFO
1 stop7h 15mMultiple Airlines
Wed 12/310:10 pmSFO - DSM
2 stops42h 53mMultiple Airlines
Deal found 10/29$245
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:35 pmDSM - SFO
2 stops31h 55mMultiple Airlines
Fri 1/96:00 amSFO - DSM
1 stop7h 40mMultiple Airlines
Deal found 10/30$246
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:28 pmDSM - SFO
1 stop14h 20mMultiple Airlines
Fri 12/196:00 amSFO - DSM
2 stops35h 44mMultiple Airlines
Deal found 10/27$252
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/243:31 pmOMA - SFO
1 stop7h 57mAmerican Airlines
Fri 11/287:12 amSFO - OMA
1 stop5h 49mAmerican Airlines
Deal found 10/28$253

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Iowa to San Francisco that are best for you.

Fly from

Iowa

Fly to

San Francisco

Route

Depart

Return

Price

Cedar RapidsSan Francisco

CID - SFO

CIDSFO

Cedar Rapids

Fri 11/14

8:26 pm-12:14 am

1 stop5h 48m

San Francisco

Sun 11/16

6:34 am-7:36 pm

1 stop11h 02m

$254

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sat 1/17

1:50 pm-5:50 pm

1 stop6h 00m

San Francisco

Fri 1/23

4:22 pm-9:53 pm

Nonstop3h 31m

$259

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sun 12/7

6:20 pm-12:03 am

1 stop7h 43m

San Francisco

Sat 12/13

5:55 am-4:49 pm

1 stop8h 54m

$269

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Mon 3/2

3:05 pm-10:18 pm

1 stop9h 13m

San Francisco

Wed 3/4

6:00 am-2:12 pm

1 stop6h 12m

$269

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Thu 2/5

5:18 pm-10:58 pm

1 stop7h 40m

San Francisco

Tue 2/10

2:42 pm-11:07 pm

1 stop6h 25m

$269

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Sat 2/14

6:10 pm-10:57 pm

1 stop6h 47m

San Francisco

Tue 2/17

10:45 pm-9:45 am

1 stop9h 00m

$269

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Mon 3/23

5:35 pm-11:55 pm

1 stop8h 20m

San Francisco

Mon 3/30

10:40 pm-10:08 am

1 stop9h 28m

$284

Des MoinesSan Francisco

DSM - SFO

DSMSFO

Des Moines

Tue 12/30

2:35 pm-8:30 pm

2 stops31h 55m

San Francisco

Thu 1/8

6:00 am-3:40 pm

1 stop7h 40m

$285

OmahaSan Francisco

OMA - SFO

OMASFO

Omaha Eppley Airfield

Fri 11/28

7:36 am-9:47 am

Nonstop4h 11m

San Francisco

Mon 12/1

11:50 pm-10:31 am

1 stop8h 41m

$285

MolineSan Francisco

MLI - SFO

MLISFO

Moline Quad-City

Tue 12/16

10:50 am-3:35 pm

1 stop6h 45m

San Francisco

Sun 12/21

11:35 pm-10:12 am

1 stop8h 37m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 60 results
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Best time to book a flight from Iowa to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to San Francisco

What is the cheapest month to book a flight from Iowa to San Francisco?

Currently, October is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $108). Flying from Iowa to San Francisco in September is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to SFO?

Find hourly flight availability from Iowa to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

When flying from Iowa to San Francisco, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 44% versus a flight in the morning.

What is the cheapest day to fly from Iowa to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Iowa to San Francisco. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Iowa to San Francisco flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Iowa to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Iowa?

    San Francisco (SFO), located 11.8 mi from the city center, is the airport you fly into when you book flights from Iowa to San Francisco.

  • How long is the flight from Iowa to San Francisco?

    A quick flight from Iowa to San Francisco can take about 5h 48m. Frontier provides one of the quickest options available for as low as $254. There are 1645 mi between Iowa and San Francisco. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Iowa to San Francisco?

    The most popular route from Iowa to San Francisco is Omaha Eppley Airfield - San Francisco. You may also consider Des Moines - San Francisco or Cedar Rapids - San Francisco.

  • Can I find deals for flights from Iowa to San Francisco that include hotel bookings?

    Yes. In addition to deals on Iowa to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to San Francisco.

  • Can I find deals for business class flights from Iowa to San Francisco?

    Yes. Cheapflights offers flight deals from Iowa to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to San Francisco?

    Currently, October is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $108). Flying from Iowa to San Francisco in September is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Watsonville
Sunnyvale
Santa Clara
Antioch
Manteca
Vallejo
Hollister
Vacaville
San Bruno
Foster City
Redwood City
Union City
Fairfield
Burlingame
Lodi

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Alternative routes for Iowa to San Francisco

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Top 5 airlines flying from Iowa to San Francisco

Discover the top 5 airlines that operate flights from Iowa to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$129Average$236FlexibilityNo cancel feeOn-time62%
DeltaCheapest$265Average$376FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$288Average$476FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$288Average$437FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$344Average$426FlexibilityNo cancel feeOn-time63%

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