$80+ Cheap flights from Iowa to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SFO
Apr 29 — May 61
Round-trip
1 adult, Economy
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Find cheap flights from Iowa to San Francisco with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Iowa to San FranciscoExplore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
Explore the most affordable flight options available from Iowa to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 30, 2026.
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:49 pm
OMA
- SFO
1 stop5h 38m
Frontier
Mon 4/206:00 am
SFO
- OMA
1 stop12h 13m
Frontier
Deal found 3/29![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Wed 5/136:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 3/27![Frontier logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:19 pm
OMA
- SFO
1 stop17h 23m
Frontier
Tue 6/96:00 am
SFO
- OMA
1 stop11h 34m
Frontier
Deal found 3/25![Frontier logo]()
$202
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:36 pm
CID
- SFO
1 stop11h 51m
Frontier
Mon 4/206:00 am
SFO
- CID
1 stop5h 51m
Frontier
Deal found 3/27![Frontier logo]()
$205
This Frontier deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:49 pm
OMA
- SFO
1 stop5h 38m
Frontier
Sat 5/238:56 am
SFO
- OMA
1 stop8h 38m
Frontier
Deal found 3/26![Frontier logo]()
$210
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Mon 6/16:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 3/27![Frontier logo]()
$210
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:51 pm
CID
- SFO
1 stop12h 32m
Frontier
Sat 5/238:56 am
SFO
- CID
1 stop8h 32m
Frontier
Deal found 3/27![Frontier logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:58 pm
OMA
- SFO
1 stop28h 27m
Frontier
Mon 5/49:58 am
SFO
- OMA
2 stops31h 26m
Frontier
Deal found 3/28![Frontier logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/268:19 pm
OMA
- SFO
1 stop17h 23m
Frontier
Mon 6/110:04 pm
SFO
- OMA
2 stops19h 20m
Frontier
Deal found 3/26![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- SFO
1 stop23h 26m
Frontier
Mon 5/1810:40 pm
SFO
- DSM
2 stops36h 51m
Frontier
Deal found 3/27![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:19 pm
OMA
- SFO
1 stop17h 23m
Frontier
Tue 5/266:00 am
SFO
- OMA
1 stop11h 24m
Frontier
Deal found 3/26![Frontier logo]()
$213
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:58 pm
OMA
- SFO
1 stop14h 15m
Frontier
Mon 4/206:00 am
SFO
- OMA
1 stop12h 13m
Frontier
Deal found 3/26![Frontier logo]()
$216
Best flights from Iowa to San FranciscoDiscover carefully curated flight deals from Iowa to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
Discover carefully curated flight deals from Iowa to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 30, 2026.
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:50 am
OMA
- SFO
2 stops8h 00m
Southwest
Sat 5/26:15 am
SFO
- OMA
2 stops8h 35m
Southwest
Deal found 3/26![Southwest logo]()
$270
This United Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:23 am
OMA
- SFO
Nonstop4h 07m
United Airlines
Sun 5/311:59 pm
SFO
- OMA
Nonstop3h 33m
United Airlines
Deal found 3/28![United Airlines logo]()
$309
This Alaska Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:17 pm
OMA
- SFO
1 stop10h 10m
Alaska Airlines
Sat 4/257:59 pm
SFO
- OMA
1 stop16h 04m
Alaska Airlines
Deal found 3/27![Alaska Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:17 pm
MLI
- SFO
1 stop9h 29m
Delta
Tue 6/211:59 pm
SFO
- MLI
1 stop8h 21m
Delta
Deal found 3/29![Delta logo]()
$350
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:37 pm
LSE
- SFO
1 stop7h 22m
American Airlines
Mon 4/136:40 pm
SFO
- LSE
2 stops12h 55m
American Airlines
Deal found 3/25![American Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:21 am
OMA
- SFO
Nonstop4h 09m
United Airlines
Mon 5/1811:56 pm
SFO
- OMA
1 stop8h 33m
United Airlines
Deal found 3/27![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/181:20 pm
OMA
- SFO
1 stop9h 25m
Southwest
Sat 4/256:15 am
SFO
- OMA
2 stops8h 35m
Southwest
Deal found 3/27![Southwest logo]()
$334
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:11 pm
LSE
- SFO
1 stop8h 31m
United Airlines
Mon 8/1011:30 pm
SFO
- LSE
1 stop7h 26m
United Airlines
Deal found 3/26![United Airlines logo]()
$358
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:15 pm
DSM
- SFO
2 stops10h 00m
Southwest
Wed 5/1310:05 am
SFO
- DSM
2 stops9h 10m
Southwest
Deal found 3/27![Southwest logo]()
$359
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/97:00 am
MLI
- SFO
1 stop10h 46m
American Airlines
Mon 4/1311:59 pm
SFO
- MLI
1 stop9h 35m
American Airlines
Deal found 3/25![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:17 pm
MLI
- SFO
1 stop9h 29m
Delta
Sat 5/2311:59 pm
SFO
- MLI
1 stop8h 21m
Delta
Deal found 3/27![Delta logo]()
$429
This Alaska Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:15 am
MLI
- SFO
2 stops12h 57m
Alaska Airlines
Sat 5/97:15 am
SFO
- MLI
2 stops14h 39m
Alaska Airlines
Deal found 3/28![Alaska Airlines logo]()
$441
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:13 pm
CID
- SFO
1 stop6h 39m
United Airlines
Mon 5/1812:45 am
SFO
- CID
1 stop7h 42m
United Airlines
Deal found 3/25![United Airlines logo]()
$367
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/43:35 pm
OMA
- SFO
2 stops8h 35m
Southwest
Fri 5/83:00 pm
SFO
- OMA
2 stops8h 00m
Southwest
Deal found 3/27![Southwest logo]()
$369
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:56 pm
MLI
- SFO
1 stop6h 51m
American Airlines
Mon 6/811:14 pm
SFO
- MLI
1 stop9h 13m
American Airlines
Deal found 3/29![American Airlines logo]()
$419
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/19:05 am
MLI
- SFO
1 stop5h 59m
United Airlines
Wed 7/85:05 am
SFO
- MLI
1 stop8h 07m
United Airlines
Deal found 3/25![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:10 pm
DSM
- SFO
2 stops9h 10m
Southwest
Sat 5/211:05 am
SFO
- DSM
2 stops7h 50m
Southwest
Deal found 3/26![Southwest logo]()
$373
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:45 am
CID
- SFO
1 stop6h 40m
Delta
Wed 4/2212:37 pm
SFO
- CID
1 stop8h 15m
Delta
Deal found 3/27![Delta logo]()
$457
This Alaska Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/812:48 pm
CID
- SFO
2 stops12h 13m
Alaska Airlines
Sat 5/97:15 am
SFO
- CID
2 stops13h 04m
Alaska Airlines
Deal found 3/29![Alaska Airlines logo]()
$478
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:34 pm
MLI
- SFO
1 stop7h 05m
United Airlines
Fri 5/111:56 pm
SFO
- MLI
1 stop8h 08m
United Airlines
Deal found 3/25![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:34 pm
LSE
- SFO
1 stop8h 13m
American Airlines
Tue 6/302:47 pm
SFO
- LSE
1 stop7h 19m
American Airlines
Deal found 3/26![American Airlines logo]()
$458
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:10 pm
OMA
- SFO
1 stop6h 00m
Southwest
Sat 4/115:40 am
SFO
- OMA
1 stop5h 45m
Southwest
Deal found 3/25![Southwest logo]()
$389
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:23 pm
DSM
- SFO
1 stop6h 28m
Delta
Tue 5/56:20 am
SFO
- DSM
1 stop7h 21m
Delta
Deal found 3/29![Delta logo]()
$473
This Orbitz deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/812:48 pm
CID
- SFO
2 stops12h 13m
Alaska Airlines
Mon 5/117:15 am
SFO
- CID
2 stops13h 04m
Alaska Airlines
Deal found 3/29![Alaska Airlines logo]()
$479
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:12 pm
DSM
- SFO
1 stop5h 55m
United Airlines
Tue 5/512:45 pm
SFO
- DSM
1 stop5h 31m
United Airlines
Deal found 3/29![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:00 pm
CID
- SFO
2 stops9h 38m
American Airlines
Mon 5/116:00 am
SFO
- CID
1 stop6h 00m
American Airlines
Deal found 3/29![American Airlines logo]()
$487
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:55 am
DSM
- SFO
1 stop5h 45m
Southwest
Tue 5/1910:05 am
SFO
- DSM
2 stops9h 10m
Southwest
Deal found 3/28![Southwest logo]()
$404
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:57 am
CID
- SFO
2 stops14h 23m
Delta
Sun 5/249:30 am
SFO
- CID
2 stops11h 37m
Delta
Deal found 3/27![Delta logo]()
$520
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:00 pm
DSM
- SFO
2 stops9h 55m
Southwest
Tue 5/51:20 pm
SFO
- DSM
1 stop5h 55m
Southwest
Deal found 3/29![Southwest logo]()
$404
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:23 am
OMA
- SFO
Nonstop4h 07m
United Airlines
Sat 4/2510:50 am
SFO
- OMA
1 stop9h 38m
United Airlines
Deal found 3/29![United Airlines logo]()
$409
Last-minute flights from Iowa to San FranciscoDiscover last-minute flight deals from Iowa to San Francisco. Data last updated March 30, 2026 and is based on user searches.
Discover last-minute flight deals from Iowa to San Francisco. Data last updated March 30, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SFO
1 stop25h 51m
Frontier
Mon 4/136:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 3/25![Frontier logo]()
$226
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:14 pm
DSM
- SFO
1 stop25h 51m
Frontier
Sun 4/129:00 pm
SFO
- DSM
1 stop20h 14m
Frontier
Deal found 3/27![Frontier logo]()
$236
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:46 pm
CID
- SFO
1 stop11h 42m
Frontier
Mon 4/206:00 am
SFO
- CID
1 stop5h 51m
Frontier
Deal found 3/27![Frontier logo]()
$235
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:58 pm
OMA
- SFO
1 stop14h 15m
Frontier
Mon 4/206:00 am
SFO
- OMA
1 stop12h 13m
Frontier
Deal found 3/26![Frontier logo]()
$216
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/163:35 pm
OMA
- SFO
2 stops8h 35m
Southwest
Wed 4/225:55 am
SFO
- OMA
1 stop5h 20m
Southwest
Deal found 3/26![Southwest logo]()
$244
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:49 pm
OMA
- SFO
1 stop5h 38m
Frontier
Mon 4/206:00 am
SFO
- OMA
1 stop12h 13m
Frontier
Deal found 3/29![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:36 pm
CID
- SFO
1 stop11h 51m
Frontier
Mon 4/206:00 am
SFO
- CID
1 stop5h 51m
Frontier
Deal found 3/27![Frontier logo]()
$205
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:36 pm
CID
- SFO
1 stop11h 51m
Frontier
Mon 4/276:00 am
SFO
- CID
1 stop5h 51m
Frontier
Deal found 3/27![Frontier logo]()
$230
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:35 pm
OMA
- SFO
1 stop10h 00m
Southwest
Thu 4/235:25 am
SFO
- OMA
1 stop5h 30m
Southwest
Deal found 3/25![Southwest logo]()
$239
This Expedia deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:58 pm
OMA
- SFO
1 stop5h 29m
Frontier
Mon 4/276:00 am
SFO
- OMA
1 stop12h 13m
Frontier
Deal found 3/29![Frontier logo]()
$230
This Expedia deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:58 pm
OMA
- SFO
1 stop5h 29m
Frontier
Mon 5/46:00 am
SFO
- OMA
1 stop11h 58m
Frontier
Deal found 3/28![Frontier logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/279:55 pm
MLI
- SFO
2 stops25h 44m
Multiple Airlines
Wed 4/292:47 pm
SFO
- MLI
1 stop18h 42m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$235
One-way flights from Iowa to San FranciscoSearch for one-way flight options from Iowa to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
Search for one-way flight options from Iowa to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 30, 2026.
This Priceline deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:49 pm
OMA
- SFO
1 stop5h 38m
Frontier
Deal found 3/27![Frontier logo]()
$80
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:36 pm
CID
- SFO
1 stop11h 51m
Frontier
Deal found 3/29![Frontier logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:58 pm
OMA
- SFO
1 stop28h 27m
Frontier
Deal found 3/29![Frontier logo]()
$102
This Frontier deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:19 pm
OMA
- SFO
1 stop6h 04m
Frontier
Deal found 3/26![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:19 pm
OMA
- SFO
1 stop17h 23m
Frontier
Deal found 3/26![Frontier logo]()
$106
This Frontier deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:36 pm
CID
- SFO
1 stop11h 51m
Frontier
Deal found 3/29![Frontier logo]()
$106
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:45 pm
OMA
- SFO
1 stop6h 00m
Southwest
Deal found 3/26![Southwest logo]()
$109
This Expedia deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:19 pm
OMA
- SFO
1 stop17h 23m
Frontier
Deal found 3/25![Frontier logo]()
$111
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- SFO
1 stop12h 07m
Frontier
Deal found 3/27![Frontier logo]()
$111
This Frontier deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/71:51 pm
CID
- SFO
1 stop12h 32m
Frontier
Deal found 3/26![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:14 pm
DSM
- SFO
1 stop22h 31m
Multiple Airlines
Deal found 3/28![Multiple Airlines logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:59 pm
OMA
- SFO
2 stops42h 53m
Frontier
Deal found 3/25![Frontier logo]()
$123
Find flight deals from Iowa to San Francisco
Keep the following information in mind while searching for Iowa to San Francisco flight deals. Data was last updated March 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $180 (Frontier) |
One-way from | $80 (Priceline) |
Popular in | March |
Cheapest in | February |
Average price | $516 |
Cheapflights Fare Finder
Customize your flight search to find flights from Iowa to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from Iowa to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Sat 4/25
5:50 am-11:50 am
2 stops8h 00m
San Francisco
Sat 5/2
6:15 am-4:50 pm
2 stops8h 35m
$270
Quickest round-trip
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Sun 4/26
7:23 am-9:30 am
Nonstop4h 07m
San Francisco
Sun 5/3
11:59 pm-5:32 am
Nonstop3h 33m
$309
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Sat 4/18
2:17 pm-10:27 pm
1 stop10h 10m
San Francisco
Sat 4/25
7:59 pm-2:03 pm
1 stop16h 04m
$319
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Thu 5/7
7:21 am-9:30 am
Nonstop4h 09m
San Francisco
Mon 5/18
11:56 pm-10:29 am
1 stop8h 33m
$319
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Sat 4/18
1:20 pm-8:45 pm
1 stop9h 25m
San Francisco
Sat 4/25
6:15 am-4:50 pm
2 stops8h 35m
$334
MolineSan Francisco
MLI - SFO
MLISFO
Moline Quad-City
Fri 5/29
5:17 pm-12:46 am
1 stop9h 29m
San Francisco
Tue 6/2
11:59 pm-10:20 am
1 stop8h 21m
$350
La CrosseSan Francisco
LSE - SFO
LSESFO
La Crosse
Sun 6/21
7:11 pm-1:42 am
1 stop8h 31m
San Francisco
Mon 8/10
11:30 pm-8:56 am
1 stop7h 26m
$358
Des MoinesSan Francisco
DSM - SFO
DSMSFO
Des Moines
Wed 5/6
3:15 pm-11:15 pm
2 stops10h 00m
San Francisco
Wed 5/13
10:05 am-9:15 pm
2 stops9h 10m
$359
Cedar RapidsSan Francisco
CID - SFO
CIDSFO
Cedar Rapids
Tue 5/12
3:13 pm-7:52 pm
1 stop6h 39m
San Francisco
Mon 5/18
12:45 am-10:27 am
1 stop7h 42m
$367
OmahaSan Francisco
OMA - SFO
OMASFO
Omaha Eppley Airfield
Mon 5/4
3:35 pm-10:10 pm
2 stops8h 35m
San Francisco
Fri 5/8
3:00 pm-1:00 am
2 stops8h 00m
$369
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Iowa to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Iowa with our price prediction graph.
OMA-SFO
DSM-SFO
CID-SFO
MLI-SFO
LSE-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Iowa to San Francisco
USIA-SFO
OMA-SFO
DSM-SFO
CID-SFO
MLI-SFO
What is the cheapest month to book a flight from Iowa to San Francisco?
Currently, December is the cheapest month in which you can book a flight from Iowa to San Francisco (average of $144). Flying from Iowa to San Francisco in March is currently the most expensive (average of $302). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Iowa to San Francisco?
Related info for your journey
Find useful and relevant information for your journey from Iowa to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Rancho Cordova
San Bruno
Watsonville
San Ramon
Sunnyvale
Vacaville
San Carlos
Redwood City
Turlock
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Foster City
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Iowa to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Iowa to San Francisco by cabin class
Find flights from Iowa to San Francisco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Iowa and San Francisco flights
Browse other Iowa and San Francisco flight options. Last updated on March 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 30, 2026.
Iowa to San Francisco flights
Consider these flights traveling from Iowa to San Francisco.
Top 5 airlines flying from Iowa to San Francisco
Discover the top 5 airlines that operate flights from Iowa to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$129 | Average$240 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$265 | Average$365 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$288 | Average$469 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$288 | Average$440 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$336 | Average$447 | FlexibilityNo cancel fee | On-time63% |