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$345+ Cheap flights from the Cayman Islands to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.
GCM — SFO
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Cayman Islands to San Francisco

Keep the following information in mind while searching for Cayman Islands to San Francisco flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$650
(Southwest)

One-way from

$345
(Southwest)

Popular in

July

Cheapest in

February

Average price

$734
Provider with most accurate pricing for George Town Owen Roberts Intl-San Francisco flight deals.
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Provider most trusted by Cheapflights users for George Town Owen Roberts Intl-San Francisco flights.
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From Cayman Islands to San Francisco
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One-way flight from Cayman Islands to San Francisco
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Highest demand for flights based on searches. 14% potential increase in price ($121 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Cayman Islands to San Francisco

Cheapest flights from Cayman Islands to San Francisco
Explore the most affordable flight options available from Cayman Islands to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/3012:45 pmGCM - SFO
2 stops13h 25mSouthwest
Thu 7/39:00 pmSFO - GCM
2 stops12h 50mSouthwest
Deal found 4/29$650
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/412:35 pmGCM - SFO
1 stop12h 23mDelta
Wed 6/114:00 pmSFO - GCM
2 stops17h 25mDelta
Deal found 4/29$701
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/41:35 pmGCM - SFO
1 stop10h 46mUnited Airlines
Tue 6/1012:43 amSFO - GCM
1 stop9h 47mUnited Airlines
Deal found 4/29$710
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/412:25 pmGCM - SFO
2 stops13h 57mAmerican Airlines
Wed 6/116:47 pmSFO - GCM
2 stops14h 17mAmerican Airlines
Deal found 4/29$739
This Expedia deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/3011:30 amGCM - SFO
2 stops37h 15mMultiple Airlines
Wed 7/212:05 amSFO - GCM
2 stops14h 55mMultiple Airlines
Deal found 4/29$1,384

Cheapflights Fare Finder

Customize your flight search to find flights from Cayman Islands to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from the Cayman Islands to San Francisco that are best for you.

Fly from

Cayman Islands

Fly to

San Francisco

Route

Depart

Return

Price

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 6/30

12:45 pm-12:10 am

2 stops13h 25m

San Francisco

Thu 7/3

9:00 pm-11:50 am

2 stops12h 50m

$650

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 6/4

12:35 pm-10:58 pm

1 stop12h 23m

San Francisco

Wed 6/11

4:00 pm-11:25 am

2 stops17h 25m

$701

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 6/4

1:35 pm-10:21 pm

1 stop10h 46m

San Francisco

Tue 6/10

12:43 am-12:30 pm

1 stop9h 47m

$710

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Wed 6/4

12:25 pm-12:22 am

2 stops13h 57m

San Francisco

Wed 6/11

6:47 pm-11:04 am

2 stops14h 17m

$739

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 6/30

11:30 am-10:45 pm

2 stops37h 15m

San Francisco

Wed 7/2

12:05 am-5:00 pm

2 stops14h 55m

$1,384

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 7/22

12:45 pm-11:30 pm

2 stops12h 45m

$345

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 7/22

1:45 pm-12:05 pm

3 stops24h 20m

$387

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Sat 7/19

8:30 am-11:25 pm

1 stop16h 55m

$416

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Mon 7/21

12:50 pm-10:48 am

1 stop23h 58m

$429

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

Tue 7/22

12:40 pm-10:49 pm

1 stop12h 09m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 12 results
1
2

Best time to book a flight from Cayman Islands to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Cayman Islands with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from the Cayman Islands to San Francisco

What is the cheapest month to book a flight from Cayman Islands to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Cayman Islands to San Francisco (average of $276). Flying from Cayman Islands to San Francisco in June is currently the most expensive (average of $384). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated May 1, 2025.
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Crew

8.6

Boarding

8.2

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Southwest
8.0
Very good
4,294 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Crew

8.6

Boarding

8.2

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
Delta
8.0
Very good
7,934 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Crew

8.6

Boarding

8.2

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Crew

8.6

Boarding

8.2

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Crew

8.6

Boarding

8.2

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.
WestJet
7.2
Good
2,826 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Crew

8.6

Boarding

8.2

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Related info for your journey

Find useful and relevant information for your journey from Cayman Islands to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Cayman Islands?

    San Francisco (SFO), located 11.8 mi from the city center, is the airport you fly into when you book flights from Cayman Islands to San Francisco.

  • What are the cheapest airlines to fly from Cayman Islands to San Francisco one-way?

    One-way options have recently been found by users for as low as $345 on Southwest. Other airlines that offer cheap prices include WestJet from $387 and Air Canada from $429 one-way.

  • Can I find deals for flights from Cayman Islands to San Francisco that include hotel bookings?

    Yes. In addition to deals on Cayman Islands to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cayman Islands to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cayman Islands to San Francisco.

  • Can I find deals for business class flights from Cayman Islands to San Francisco?

    Yes. Cheapflights offers flight deals from Cayman Islands to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cayman Islands to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Cayman Islands to San Francisco (average of $276). Flying from Cayman Islands to San Francisco in June is currently the most expensive (average of $384). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near the Cayman Islands?

Book flights to the Cayman Islands if you plan to visit one of these locations
Roseville
Mountain View
Santa Cruz
Livermore
South San Francisco
Turlock
Manteca
Fairfield
Richmond
Watsonville
Hollister
Newark
Milpitas
Antioch
Sausalito
Hayward
Alameda
Sunnyvale
Campbell
Daly City

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Cayman Islands to San Francisco

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Top airline flying from Cayman Islands to San Francisco

Discover the top airline that operate flights from Cayman Islands to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$675Average$734FlexibilityNo cancel feeOn-time71%

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