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$250+ Cheap flights from the Cayman Islands to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
GCM — SFO
ene. 22 — ene. 291
jue. 1/22
jue. 1/29
1 adult, Economy
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Cheap flight deals from Cayman Islands to San Francisco

Best flights from Cayman Islands to San Francisco
Discover carefully curated flight deals from Cayman Islands to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated diciembre 23, 2025.

This JetBlue deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/212:55 pmGCM - SFO
1 stop11h 00mJetBlue
lun. 5/259:00 pmSFO - GCM
1 stop14h 55mJetBlue
Deal found 12/21$411
This Southwest deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/201:05 pmGCM - SFO
2 stops12h 30mSouthwest
lun. 5/259:15 pmSFO - GCM
2 stops12h 55mSouthwest
Deal found 12/21$565
This Expedia deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/208:00 amGCM - SFO
1 stop17h 59mMultiple Airlines
lun. 5/259:00 pmSFO - GCM
1 stop14h 55mMultiple Airlines
Deal found 12/21$584
This Air Canada deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/1312:25 pmGCM - SFO
2 stops25h 48mAir Canada
mié. 6/174:30 pmSFO - GCM
1 stop17h 00mAir Canada
Deal found 12/23$770
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/134:15 pmGCM - SFO
1 stop11h 01mUnited Airlines
mar. 6/1612:45 amSFO - GCM
1 stop9h 45mUnited Airlines
Deal found 12/21$775

Find flight deals from Cayman Islands to San Francisco

Keep the following information in mind while searching for Cayman Islands to San Francisco flight deals. Data was last updated diciembre 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$411
(JetBlue)

One-way from

$250
(JetBlue)

Popular in

November

Cheapest in

February

Average price

$536
Provider with most accurate pricing for George Town Owen Roberts Intl-San Francisco flight deals.
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Provider most trusted by Cheapflights users for George Town Owen Roberts Intl-San Francisco flights.
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From Cayman Islands to San Francisco
Search Deals
One-way flight from Cayman Islands to San Francisco
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Highest demand for flights based on searches. 22% potential increase in price ($205 potential increase over avg. RT price).
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Cheapest flight prices on average. 14% potential price decrease ($87 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Cayman Islands to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 23, 2025.
Use the filters below to find and compare flights from the Cayman Islands to San Francisco that are best for you.

Fly from

Cayman Islands

Fly to

San Francisco

Route

Depart

Return

Price

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

jue. 5/21

2:55 pm-11:55 pm

1 stop11h 00m

San Francisco

lun. 5/25

9:00 pm-1:55 pm

1 stop14h 55m

$411

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

mié. 5/20

1:05 pm-11:35 pm

2 stops12h 30m

San Francisco

lun. 5/25

9:15 pm-12:10 pm

2 stops12h 55m

$565

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

mié. 5/20

8:00 am-11:59 pm

1 stop17h 59m

San Francisco

lun. 5/25

9:00 pm-1:55 pm

1 stop14h 55m

$584

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

sáb. 6/13

12:25 pm-12:13 pm

2 stops25h 48m

San Francisco

mié. 6/17

4:30 pm-11:30 am

1 stop17h 00m

$770

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

sáb. 6/13

4:15 pm-1:16 am

1 stop11h 01m

San Francisco

mar. 6/16

12:45 am-12:30 pm

1 stop9h 45m

$775

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

mar. 1/13

3:30 pm-11:29 pm

1 stop10h 59m

$250

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

mar. 1/13

1:30 pm-10:34 am

2 stops24h 04m

$342

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

sáb. 6/13

11:30 am-10:20 pm

2 stops12h 50m

$385

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

vie. 6/12

1:35 pm-12:18 pm

1 stop24h 43m

$443

George TownSan Francisco

GCM - SFO

GCMSFO

George Town Owen Roberts Intl

sáb. 6/13

12:40 pm-8:25 pm

1 stop9h 45m

$448

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/21

Showing 1-10 of 14 results
1
2

Best time to book a flight from Cayman Islands to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Cayman Islands with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from the Cayman Islands to San Francisco
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated diciembre 23, 2025.
Get a feel of what it's like to fly with American Airlines from the Cayman Islands to San Francisco by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,054 reviews

Entertainment

6.9

Overall

7.2

Boarding

7.5

Food

6.4

Crew

8.0

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,054 reviews
American Airlines
7.2
Good
11,054 reviews

Entertainment

6.9

Overall

7.2

Boarding

7.5

Food

6.4

Crew

8.0

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Cayman Islands to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Cayman Islands?

    San Francisco (SFO), located 11.8 mi from the city center, is the airport you fly into when you book flights from Cayman Islands to San Francisco.

  • How long is the flight from Cayman Islands to San Francisco?

    Airlines like JetBlue and Southwest fly from Cayman Islands to San Francisco in about 11h. The time it takes to get you to your destination can typically vary by up to 1h 30m. Airlines will cover a distance of 2764 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Cayman Islands to San Francisco that include hotel bookings?

    Yes. In addition to deals on Cayman Islands to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cayman Islands to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cayman Islands to San Francisco.

  • Can I find deals for business class flights from Cayman Islands to San Francisco?

    Yes. Cheapflights offers flight deals from Cayman Islands to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Redwood City
Sunnyvale
San Bruno
Daly City
Santa Clara
San Carlos
Vallejo
Hollister
San Ramon
Foster City
Union City
Davis
Emeryville

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Top airline flying from Cayman Islands to San Francisco

Discover the top airline that operate flights from Cayman Islands to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$709Average$1,478FlexibilityNo cancel feeOn-time71%

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