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$318+ Cheap flights from La Crosse to San Diego (LSE - SAN)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel.
LSE — SAN
Apr 11 — Apr 181
Sat 4/11
Sat 4/18
1 adult, Economy
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Cheap flight deals from La Crosse to San Diego

Cheapest flights from La Crosse to San Diego
Explore the most affordable flight options available from La Crosse to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.

This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:37 pm
LSE
-
SAN
1 stop6h 56m
American Airlines
Sat 4/251:03 pm
SAN
-
LSE
1 stop8h 51m
American Airlines
Deal found 3/8$318
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2210:05 am
LSE
-
SAN
2 stops13h 50m
American Airlines
Tue 4/289:28 am
SAN
-
LSE
2 stops12h 26m
American Airlines
Deal found 3/10$329
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:37 pm
LSE
-
SAN
1 stop6h 56m
American Airlines
Sun 4/2610:40 pm
SAN
-
LSE
1 stop8h 55m
American Airlines
Deal found 3/9$388
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:34 pm
LSE
-
SAN
1 stop8h 05m
American Airlines
Mon 6/87:15 pm
SAN
-
LSE
2 stops14h 07m
American Airlines
Deal found 3/9$402
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:37 pm
LSE
-
SAN
1 stop6h 56m
American Airlines
Sun 4/2610:40 pm
SAN
-
LSE
1 stop8h 55m
American Airlines
Deal found 3/11$408
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:35 pm
LSE
-
SAN
1 stop7h 53m
American Airlines
Sat 7/117:30 am
SAN
-
LSE
1 stop7h 35m
American Airlines
Deal found 3/9$423
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:37 pm
LSE
-
SAN
1 stop6h 56m
American Airlines
Thu 5/211:19 pm
SAN
-
LSE
1 stop8h 47m
American Airlines
Deal found 3/10$428
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/411:52 am
LSE
-
SAN
1 stop8h 34m
American Airlines
Mon 6/810:45 pm
SAN
-
LSE
1 stop16h 19m
American Airlines
Deal found 3/7$436

Find flight deals from La Crosse to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from La Crosse (LSE) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$318
(American Airlines)
Provider with most accurate pricing for La Crosse-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for La Crosse-San Diego flights.
Search Deals
From La Crosse to San Diego
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Cheapflights Fare Finder

 
Customize your flight search to find flights from La Crosse to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from La Crosse to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Thu 5/7

6:37 pm-11:33 pm

1 stop6h 56m

San Diego

Mon 5/11

3:09 pm-11:54 pm

1 stop6h 45m

$318

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Wed 4/22

10:05 am-9:55 pm

2 stops13h 50m

San Diego

Tue 4/28

1:03 pm-11:54 pm

1 stop8h 51m

$324

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Wed 4/22

6:37 pm-11:33 pm

1 stop6h 56m

San Diego

Sun 4/26

10:40 pm-9:35 am

1 stop8h 55m

$408

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Wed 6/3

5:34 pm-11:39 pm

1 stop8h 05m

San Diego

Sat 6/6

1:19 pm-12:06 am

1 stop8h 47m

$423

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Sat 7/4

6:00 am-3:32 pm

2 stops11h 32m

San Diego

Sat 7/11

1:09 pm-11:59 pm

1 stop8h 50m

$429

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Tue 9/8

6:37 pm-11:23 pm

1 stop6h 46m

San Diego

Sun 9/13

11:00 pm-9:12 am

1 stop8h 12m

$443

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Sat 6/20

11:44 am-6:26 pm

1 stop8h 42m

San Diego

Sat 6/27

1:19 pm-12:06 am

1 stop8h 47m

$443

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Thu 7/30

5:35 pm-11:28 pm

1 stop7h 53m

San Diego

Mon 8/3

10:28 pm-11:15 am

2 stops10h 47m

$479

La CrosseSan Diego

LSE - SAN

LSESAN

La Crosse

Thu 7/30

5:35 pm-11:28 pm

1 stop7h 53m

San Diego

Sun 8/2

7:30 am-5:05 pm

1 stop7h 35m

$494

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/8

Sorted by cheapest first

Compare providers for flights from La Crosse to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from La Crosse to San Diego in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on La Crosse-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on La Crosse-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from La Crosse-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on La Crosse-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for La Crosse-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from La Crosse to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from La Crosse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from La Crosse to San Diego

What is the cheapest month to book a flight from La Crosse to San Diego?

Currently, May is the cheapest month in which you can book a flight from La Crosse to San Diego (average of $266). Flying from La Crosse to San Diego in August is currently the most expensive (average of $468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from La Crosse to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from La Crosse to San Diego?

    For as low as $318, American Airlines can have you in San Diego from La Crosse in 6h 56m. La Crosse and San Diego are separated by a distance of 1593 mi.

  • Can I find deals for flights from La Crosse to San Diego that include hotel bookings?

    Yes. In addition to deals on La Crosse to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from La Crosse to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from La Crosse to San Diego.

  • Can I find deals for business class flights from La Crosse to San Diego?

    Yes. Cheapflights offers flight deals from La Crosse to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from La Crosse to San Diego?

    Currently, May is the cheapest month in which you can book a flight from La Crosse to San Diego (average of $266). Flying from La Crosse to San Diego in August is currently the most expensive (average of $468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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