$109+ Cheap flights from Knoxville to San Antonio (TYS - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAT
Mar 22 — Mar 291
1 adult, Economy
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Find cheap flights from Knoxville to San Antonio with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to San AntonioExplore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.
Explore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2026.
This Priceline deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:20 pm
TYS
- SAT
1 stop8h 59m
Frontier
Mon 4/136:45 am
SAT
- TYS
1 stop7h 43m
Frontier
Deal found 2/17![Frontier logo]()
$160
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:00 am
TYS
- SAT
1 stop5h 20m
American Airlines
Tue 3/173:15 pm
SAT
- TYS
1 stop7h 05m
American Airlines
Deal found 2/18![American Airlines logo]()
$217
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:05 am
TYS
- SAT
1 stop4h 45m
United Airlines
Sat 5/211:45 am
SAT
- TYS
2 stops8h 00m
United Airlines
Deal found 2/18![United Airlines logo]()
$222
This Frontier deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/304:20 pm
TYS
- SAT
1 stop8h 57m
Frontier
Mon 4/66:45 am
SAT
- TYS
1 stop7h 43m
Frontier
Deal found 2/18![Frontier logo]()
$230
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:57 pm
TYS
- SAT
1 stop6h 02m
American Airlines
Sat 4/186:00 am
SAT
- TYS
1 stop5h 30m
American Airlines
Deal found 2/19![American Airlines logo]()
$240
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/24:29 pm
TYS
- SAT
1 stop7h 38m
American Airlines
Sat 4/45:36 pm
SAT
- TYS
1 stop5h 15m
American Airlines
Deal found 2/17![American Airlines logo]()
$243
This Expedia deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/204:20 pm
TYS
- SAT
1 stop17h 46m
Frontier
Mon 3/236:45 am
SAT
- TYS
1 stop7h 40m
Frontier
Deal found 2/18![Frontier logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:03 pm
TYS
- SAT
1 stop25h 15m
Multiple Airlines
Fri 6/510:26 am
SAT
- TYS
1 stop7h 11m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$257
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:00 am
TYS
- SAT
2 stops9h 39m
United Airlines
Sun 5/106:02 pm
SAT
- TYS
1 stop4h 42m
United Airlines
Deal found 2/19![United Airlines logo]()
$263
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/179:00 am
TYS
- SAT
1 stop5h 08m
United Airlines
Mon 4/206:02 pm
SAT
- TYS
1 stop4h 39m
United Airlines
Deal found 2/17![United Airlines logo]()
$266
Best flights from Knoxville to San AntonioDiscover carefully curated flight deals from Knoxville to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 20, 2026.
Discover carefully curated flight deals from Knoxville to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 20, 2026.
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
TYS
- SAT
1 stop4h 36m
American Airlines
Mon 5/115:45 pm
SAT
- TYS
1 stop5h 11m
American Airlines
Deal found 2/16![American Airlines logo]()
$240
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:35 am
TYS
- SAT
1 stop5h 25m
Delta
Wed 4/15:30 pm
SAT
- TYS
1 stop5h 27m
Delta
Deal found 2/17![Delta logo]()
$258
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:15 pm
TYS
- SAT
1 stop4h 48m
United Airlines
Mon 4/206:02 pm
SAT
- TYS
1 stop4h 39m
United Airlines
Deal found 2/17![United Airlines logo]()
$266
This Southwest deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/23:55 pm
TYS
- SAT
1 stop6h 05m
Southwest
Mon 5/1111:10 am
SAT
- TYS
2 stops9h 05m
Southwest
Deal found 2/16![Southwest logo]()
$266
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:57 pm
TYS
- SAT
1 stop6h 02m
American Airlines
Sat 4/186:00 am
SAT
- TYS
1 stop5h 30m
American Airlines
Deal found 2/19![American Airlines logo]()
$240
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:35 am
TYS
- SAT
1 stop5h 15m
Delta
Wed 4/15:30 pm
SAT
- TYS
1 stop5h 27m
Delta
Deal found 2/17![Delta logo]()
$273
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:05 am
TYS
- SAT
2 stops9h 00m
Southwest
Sat 5/27:40 am
SAT
- TYS
2 stops9h 50m
Southwest
Deal found 2/18![Southwest logo]()
$275
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:09 pm
TYS
- SAT
1 stop7h 43m
American Airlines
Sun 4/267:00 am
SAT
- TYS
1 stop4h 30m
American Airlines
Deal found 2/16![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1612:15 pm
TYS
- SAT
1 stop10h 40m
Southwest
Sat 4/187:40 am
SAT
- TYS
2 stops9h 50m
Southwest
Deal found 2/19![Southwest logo]()
$277
Last-minute flights from Knoxville to San AntonioDiscover last-minute flight deals from Knoxville to San Antonio. Data last updated February 20, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to San Antonio. Data last updated February 20, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/276:41 pm
TYS
- SAT
1 stop4h 47m
Delta
Wed 4/15:30 pm
SAT
- TYS
1 stop5h 27m
Delta
Deal found 2/17![Delta logo]()
$293
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:35 am
TYS
- SAT
1 stop5h 15m
Delta
Wed 4/15:30 pm
SAT
- TYS
1 stop5h 27m
Delta
Deal found 2/19![Delta logo]()
$273
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:35 am
TYS
- SAT
1 stop5h 15m
Delta
Mon 3/305:10 am
SAT
- TYS
1 stop5h 07m
Delta
Deal found 2/17![Delta logo]()
$299
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:35 am
TYS
- SAT
1 stop5h 25m
Delta
Mon 3/305:10 am
SAT
- TYS
1 stop5h 07m
Delta
Deal found 2/17![Delta logo]()
$281
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:35 am
TYS
- SAT
1 stop5h 25m
Delta
Tue 3/316:13 am
SAT
- TYS
1 stop4h 04m
Delta
Deal found 2/17![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:00 am
TYS
- SAT
1 stop5h 20m
American Airlines
Tue 3/173:15 pm
SAT
- TYS
1 stop7h 05m
American Airlines
Deal found 2/18![American Airlines logo]()
$217
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:31 pm
TYS
- SAT
1 stop5h 23m
American Airlines
Fri 3/205:36 pm
SAT
- TYS
1 stop5h 15m
American Airlines
Deal found 2/16![American Airlines logo]()
$284
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/173:00 pm
TYS
- SAT
1 stop19h 27m
Multiple Airlines
Thu 3/1910:22 am
SAT
- TYS
1 stop11h 04m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$285
This Expedia deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/204:20 pm
TYS
- SAT
1 stop17h 46m
Frontier
Mon 3/236:45 am
SAT
- TYS
1 stop7h 40m
Frontier
Deal found 2/18![Frontier logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/243:00 pm
TYS
- SAT
1 stop19h 27m
Multiple Airlines
Thu 3/2610:05 am
SAT
- TYS
1 stop28h 20m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$304
This Frontier deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/304:20 pm
TYS
- SAT
1 stop8h 57m
Frontier
Mon 4/66:45 am
SAT
- TYS
1 stop7h 43m
Frontier
Deal found 2/18![Frontier logo]()
$230
One-way flights from Knoxville to San AntonioSearch for one-way flight options from Knoxville to San Antonio. Find affordable one-way fares based on user searches. Data last updated February 20, 2026.
Search for one-way flight options from Knoxville to San Antonio. Find affordable one-way fares based on user searches. Data last updated February 20, 2026.
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:02 am
TYS
- SAT
1 stop5h 47m
Delta
Deal found 2/17![Delta logo]()
$109
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:00 am
TYS
- SAT
2 stops9h 46m
United Airlines
Deal found 2/17![United Airlines logo]()
$114
This American Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:00 am
TYS
- SAT
1 stop4h 36m
American Airlines
Deal found 2/17![American Airlines logo]()
$130
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:24 pm
TYS
- SAT
1 stop6h 44m
Delta
Deal found 2/19![Delta logo]()
$135
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:40 am
TYS
- SAT
1 stop4h 53m
American Airlines
Deal found 2/16![American Airlines logo]()
$150
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/113:00 pm
TYS
- SAT
1 stop8h 27m
Delta
Deal found 2/17![Delta logo]()
$160
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:00 am
TYS
- SAT
1 stop6h 15m
United Airlines
Deal found 2/17![United Airlines logo]()
$164
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:00 am
TYS
- SAT
2 stops9h 39m
United Airlines
Deal found 2/19![United Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:39 pm
TYS
- SAT
3 stops29h 39m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$192
This Southwest deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:40 am
TYS
- SAT
2 stops9h 10m
Southwest
Deal found 2/17![Southwest logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/101:14 pm
TYS
- SAT
2 stops22h 16m
Multiple Airlines
Deal found 2/17![Multiple Airlines logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:30 am
TYS
- SAT
2 stops18h 29m
Multiple Airlines
Deal found 2/16![Multiple Airlines logo]()
$212
Find flight deals from Knoxville to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $160 (Priceline) |
One-way from | $109 (Delta) |
Popular in | October |
Cheapest in | July |
Average price | $361 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.
Fly from
Knoxville
Fly to
San Antonio
Route
Depart
Return
Price
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Sat 5/2
6:00 am-9:36 am
1 stop4h 36m
San Antonio
Mon 5/11
5:45 pm-11:56 pm
1 stop5h 11m
$240
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Thu 4/16
5:57 pm-10:59 pm
1 stop6h 02m
San Antonio
Sat 4/18
6:00 am-12:30 pm
1 stop5h 30m
$240
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Tue 3/3
5:35 am-10:00 am
1 stop5h 25m
San Antonio
Wed 4/1
5:30 pm-11:57 pm
1 stop5h 27m
$258
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Fri 4/17
5:15 pm-9:03 pm
1 stop4h 48m
San Antonio
Mon 4/20
6:02 pm-11:41 pm
1 stop4h 39m
$266
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Sat 5/2
3:55 pm-9:00 pm
1 stop6h 05m
San Antonio
Mon 5/11
11:10 am-9:15 pm
2 stops9h 05m
$266
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Fri 4/24
4:09 pm-10:52 pm
1 stop7h 43m
San Antonio
Sun 4/26
7:00 am-12:30 pm
1 stop4h 30m
$269
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Sat 2/28
5:35 am-9:50 am
1 stop5h 15m
San Antonio
Wed 4/1
5:30 pm-11:57 pm
1 stop5h 27m
$273
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Wed 4/15
7:05 am-3:05 pm
2 stops9h 00m
San Antonio
Sat 5/2
7:40 am-6:30 pm
2 stops9h 50m
$275
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Thu 4/16
12:15 pm-9:55 pm
1 stop10h 40m
San Antonio
Sat 4/18
7:40 am-6:30 pm
2 stops9h 50m
$277
KnoxvilleSan Antonio
TYS - SAT
TYSSAT
Knoxville McGhee Tyson
Tue 4/14
11:02 am-3:49 pm
1 stop5h 47m
$109
Showing 1-10 of 21 results
Compare providers for flights from Knoxville to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Antonio in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Knoxville with our price prediction graph.
TYS-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to San Antonio
How far ahead should I book a flight from Knoxville to San Antonio?
Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Antonio. Price data was last updated on February 18, 2026.
To ensure you get the cheapest price possible for a flight from Knoxville to San Antonio, you should look to book at least 60 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Knoxville to San Antonio?
Currently, May is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $86). Flying from Knoxville to San Antonio in January is currently the most expensive (average of $219). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated February 20, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Antonio to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Knoxville and San Antonio flights
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Top 3 airlines flying from Knoxville to San Antonio
Discover the top 3 airlines that operate flights from Knoxville to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$232 | Average$342 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$236 | Average$325 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$237 | Average$362 | FlexibilityNo cancel fee | On-time69% |