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$160+ Cheap flights from Knoxville to San Antonio (TYS - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/18. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAT
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to San Antonio are usually found in July or January, booked 60 days in advance, depart on a Friday or Wednesday and return on a Wednesday

Cheap flight deals from Knoxville to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 17, 2025.

Round-trip from

$172
(Booking.com)

One-way from

$160
(United Airlines)

Popular in

October

Cheapest in

July

Average price

$320
From Knoxville McGhee Tyson to San Antonio
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One-way flight from Knoxville McGhee Tyson to San Antonio
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Highest demand for flights based on searches. 10% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to San Antonio

Cheapest flights from Knoxville to San Antonio
Explore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/238:17 pmTYS - SAT
1 stop24h 24mFrontier
sáb. 10/255:32 pmSAT - TYS
1 stop25h 00mFrontier
Deal found 9/16$172
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/178:17 pmTYS - SAT
1 stop21h 20mFrontier
jue. 10/2312:09 pmSAT - TYS
1 stop6h 23mFrontier
Deal found 9/16$210
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/216:00 amTYS - SAT
1 stop4h 19mAmerican Airlines
mar. 10/287:51 amSAT - TYS
1 stop8h 00mAmerican Airlines
Deal found 9/15$217
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/195:03 pmTYS - SAT
1 stop7h 02mAmerican Airlines
lun. 11/245:52 pmSAT - TYS
1 stop5h 28mAmerican Airlines
Deal found 9/16$243
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/47:59 pmTYS - SAT
1 stop5h 34mDelta
dom. 12/76:23 pmSAT - TYS
1 stop4h 28mDelta
Deal found 9/16$269
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/178:17 pmTYS - SAT
1 stop21h 20mMultiple Airlines
lun. 10/207:35 pmSAT - TYS
1 stop13h 58mMultiple Airlines
Deal found 9/16$278
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/306:08 pmTYS - SAT
1 stop6h 51mDelta
sáb. 10/45:45 pmSAT - TYS
1 stop4h 59mDelta
Deal found 9/15$279
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/307:00 amTYS - SAT
1 stop13h 48mMultiple Airlines
vie. 10/317:35 pmSAT - TYS
1 stop13h 28mMultiple Airlines
Deal found 9/15$285
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/146:18 pmTYS - SAT
1 stop4h 57mAmerican Airlines
dom. 11/168:17 amSAT - TYS
1 stop5h 02mAmerican Airlines
Deal found 9/15$294
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/175:45 amTYS - SAT
1 stop4h 47mDelta
lun. 9/225:10 amSAT - TYS
1 stop5h 31mDelta
Deal found 9/15$309

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Knoxville

Fly to

San Antonio

Route

Depart

Return

Price

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

jue. 10/23

8:17 pm-7:41 pm

1 stop24h 24m

San Antonio

sáb. 10/25

5:32 pm-7:32 pm

1 stop25h 00m

$172

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

vie. 10/17

8:17 pm-4:37 pm

1 stop21h 20m

San Antonio

jue. 10/23

12:09 pm-7:32 pm

1 stop6h 23m

$210

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

mié. 11/19

5:03 pm-11:05 pm

1 stop7h 02m

San Antonio

lun. 11/24

5:52 pm-12:20 am

1 stop5h 28m

$243

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

jue. 12/4

7:59 pm-12:33 am

1 stop5h 34m

San Antonio

dom. 12/7

6:23 pm-11:51 pm

1 stop4h 28m

$269

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

vie. 10/17

8:17 pm-4:37 pm

1 stop21h 20m

San Antonio

lun. 10/20

7:35 pm-10:33 am

1 stop13h 58m

$278

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

mar. 9/30

6:08 pm-11:59 pm

1 stop6h 51m

San Antonio

sáb. 10/4

5:45 pm-11:44 pm

1 stop4h 59m

$279

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

jue. 10/30

7:17 pm-10:14 am

2 stops15h 57m

San Antonio

vie. 10/31

7:35 pm-10:03 am

1 stop13h 28m

$287

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

vie. 11/14

6:18 pm-10:15 pm

1 stop4h 57m

San Antonio

dom. 11/16

8:17 am-2:19 pm

1 stop5h 02m

$294

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

mar. 12/2

12:09 pm-6:46 pm

1 stop7h 37m

San Antonio

jue. 12/4

6:48 am-3:54 pm

1 stop8h 06m

$319

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

sáb. 10/18

7:15 am-1:15 pm

1 stop7h 00m

$160

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 11 results
1
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Best time to book a flight from Knoxville to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Antonio

How far ahead should I book a flight from Knoxville to San Antonio?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Antonio. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Knoxville to San Antonio, you should look to book at least 60 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Knoxville to San Antonio?

Currently, August is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $295). Flying from Knoxville to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SAT?

Find hourly flight availability from Knoxville to San Antonio. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 17, 2025.

It’s optimal to fly from Knoxville to San Antonio in the evening. By choosing this option you can save up to 19% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing San Antonio

Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated septiembre 17, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Antonio to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Antonio?

    Departing from Knoxville to San Antonio will take you 5h 34m. The distance between Knoxville and San Antonio is about 945 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to San Antonio round-trip?

    Our cheapest airline available from Knoxville to San Antonio is Delta. Our recent data shows that you can find tickets from as low as $207 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $248 and $258 round-trip. Delta is 43% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Knoxville to San Antonio that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Antonio.

  • Can I find deals for business class flights from Knoxville to San Antonio?

    Yes. Cheapflights offers flight deals from Knoxville to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Antonio?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $295). Flying from Knoxville to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

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Top 3 airlines flying from Knoxville to San Antonio

Discover the top 3 airlines that operate flights from Knoxville to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$207Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$339FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$258Average$416FlexibilityNo cancel feeOn-time69%

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