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$118+ Cheap flights from Knoxville to San Antonio (TYS - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SAT
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
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Cheap flight deals from Knoxville to San Antonio

Cheapest flights from Knoxville to San Antonio
Explore the most affordable flight options available from Knoxville to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:40 am
TYS
-
SAT
1 stop4h 53m
American Airlines
Tue 3/176:00 am
SAT
-
TYS
1 stop4h 30m
American Airlines
Deal found 1/19$217
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:47 pm
TYS
-
SAT
1 stop7h 08m
American Airlines
Thu 2/266:00 am
SAT
-
TYS
1 stop4h 31m
American Airlines
Deal found 1/19$235
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:15 pm
TYS
-
SAT
1 stop6h 57m
Delta
Sat 5/165:30 am
SAT
-
TYS
1 stop6h 55m
Delta
Deal found 1/18$243
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:41 pm
TYS
-
SAT
1 stop6h 54m
Delta
Sun 2/155:30 am
SAT
-
TYS
1 stop4h 38m
Delta
Deal found 1/19$252
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:41 pm
TYS
-
SAT
1 stop6h 54m
Delta
Sun 2/155:30 am
SAT
-
TYS
1 stop4h 38m
Delta
Deal found 1/19$269
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:05 am
TYS
-
SAT
1 stop5h 28m
American Airlines
Thu 3/265:00 am
SAT
-
TYS
1 stop5h 30m
American Airlines
Deal found 1/19$270
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:40 am
TYS
-
SAT
1 stop5h 15m
Delta
Fri 4/106:17 pm
SAT
-
TYS
1 stop4h 40m
Delta
Deal found 1/19$277
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/54:06 pm
TYS
-
SAT
1 stop5h 19m
Delta
Sun 2/85:20 am
SAT
-
TYS
1 stop4h 48m
Delta
Deal found 1/18$284
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:30 am
TYS
-
SAT
1 stop18h 29m
Multiple Airlines
Mon 2/235:04 pm
SAT
-
TYS
2 stops22h 20m
Multiple Airlines
Deal found 1/18$286
This United Airlines deal was found by Cheapflights users on 1/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:49 am
TYS
-
SAT
2 stops9h 59m
United Airlines
Sat 4/112:02 pm
SAT
-
TYS
1 stop7h 27m
United Airlines
Deal found 1/17$292
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:05 pm
TYS
-
SAT
1 stop10h 54m
Multiple Airlines
Fri 3/610:26 am
SAT
-
TYS
1 stop22h 14m
Multiple Airlines
Deal found 1/18$294
This Southwest deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:50 pm
TYS
-
SAT
1 stop6h 25m
Southwest
Fri 4/101:25 pm
SAT
-
TYS
1 stop5h 55m
Southwest
Deal found 1/19$297

Find flight deals from Knoxville to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$217
(American Airlines)

One-way from

$118
(United Airlines)

Popular in

October

Cheapest in

July

Average price

$286
Provider with most accurate pricing for Knoxville McGhee Tyson-San Antonio flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-San Antonio flights.
Search Deals
From Knoxville McGhee Tyson to San Antonio
Search Deals
One-way flight from Knoxville McGhee Tyson to San Antonio
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($13 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from Knoxville to San Antonio that are best for you.

Fly from

Knoxville

Fly to

San Antonio

Route

Depart

Return

Price

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 3/11

5:40 am-9:33 am

1 stop4h 53m

San Antonio

Tue 3/17

6:00 am-11:30 am

1 stop4h 30m

$217

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 4/8

7:05 am-10:50 am

1 stop4h 45m

San Antonio

Sat 4/11

2:02 pm-10:29 pm

1 stop7h 27m

$217

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 2/24

5:47 pm-11:55 pm

1 stop7h 08m

San Antonio

Thu 2/26

6:00 am-11:31 am

1 stop4h 31m

$235

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Wed 5/13

5:15 pm-11:12 pm

1 stop6h 57m

San Antonio

Sat 5/16

5:30 am-1:25 pm

1 stop6h 55m

$243

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 2/20

6:41 pm-12:35 am

1 stop6h 54m

San Antonio

Mon 2/23

4:29 pm-11:52 pm

1 stop6h 23m

$252

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 2/13

6:41 pm-12:35 am

1 stop6h 54m

San Antonio

Sun 2/15

5:30 am-11:08 am

1 stop4h 38m

$269

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Fri 2/13

5:40 am-9:33 am

1 stop4h 53m

San Antonio

Sun 2/15

5:41 pm-11:55 pm

1 stop5h 14m

$269

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 3/24

5:05 am-9:33 am

1 stop5h 28m

San Antonio

Thu 3/26

5:00 am-11:30 am

1 stop5h 30m

$270

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Tue 4/7

5:40 am-9:55 am

1 stop5h 15m

San Antonio

Fri 4/10

6:17 pm-11:57 pm

1 stop4h 40m

$277

KnoxvilleSan Antonio

TYS - SAT

TYSSAT

Knoxville McGhee Tyson

Thu 2/5

4:06 pm-8:25 pm

1 stop5h 19m

San Antonio

Sun 2/8

5:20 am-11:08 am

1 stop4h 48m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/18

Showing 1-10 of 17 results
1
2

Compare providers for flights from Knoxville to San Antonio

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to San Antonio in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-San Antonio flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-San Antonio flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to San Antonio

How far ahead should I book a flight from Knoxville to San Antonio?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to San Antonio. Price data was last updated on January 16, 2026.

To ensure you get the cheapest price possible for a flight from Knoxville to San Antonio, you should look to book at least 60 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Knoxville to San Antonio?

Currently, May is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $86). Flying from Knoxville to San Antonio in January is currently the most expensive (average of $129). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Antonio

Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated January 20, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to San Antonio to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,077 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,077 reviews
Delta
7.9
Good
8,077 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,180 reviews
Delta
7.9
Good
8,077 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,164 reviews
Delta
7.9
Good
8,077 reviews

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to San Antonio?

    Departing from Knoxville to San Antonio will take you 4h 45m. The distance between Knoxville and San Antonio is about 945 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Knoxville to San Antonio round-trip?

    Our cheapest airline available from Knoxville to San Antonio is American Airlines. Our recent data shows that you can find tickets from as low as $232 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $236 and $237 round-trip. American Airlines is 31% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Knoxville to San Antonio one-way?

    The cheapest airlines for a one-way flight from Knoxville to San Antonio are United Airlines ($108), Delta ($159), and American Airlines ($198).

  • Can I find deals for flights from Knoxville to San Antonio that include hotel bookings?

    Yes. In addition to deals on Knoxville to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to San Antonio.

  • Can I find deals for business class flights from Knoxville to San Antonio?

    Yes. Cheapflights offers flight deals from Knoxville to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to San Antonio?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to San Antonio (average of $86). Flying from Knoxville to San Antonio in January is currently the most expensive (average of $129). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

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Top 3 airlines flying from Knoxville to San Antonio

Discover the top 3 airlines that operate flights from Knoxville to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$232Average$340FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$309FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$237Average$362FlexibilityNo cancel feeOn-time69%

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