$123+ Cheap flights from Des Moines to San Antonio (DSM - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
May 21 — May 281
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to San AntonioExplore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:20 pm
DSM
- SAT
1 stop8h 10m
Southwest
Tue 5/122:00 pm
SAT
- DSM
1 stop7h 15m
Southwest
Deal found 4/20![Southwest logo]()
$305
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:27 am
DSM
- SAT
1 stop8h 04m
Delta
Fri 6/55:25 am
SAT
- DSM
1 stop5h 43m
Delta
Deal found 4/20![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/113:20 pm
DSM
- SAT
1 stop7h 35m
United Airlines
Wed 5/135:34 pm
SAT
- DSM
1 stop5h 50m
United Airlines
Deal found 4/21![United Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1711:28 am
DSM
- SAT
1 stop6h 04m
Delta
Tue 6/236:05 am
SAT
- DSM
1 stop8h 00m
Delta
Deal found 4/16![Delta logo]()
$335
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:55 am
DSM
- SAT
1 stop5h 00m
Southwest
Tue 6/912:55 pm
SAT
- DSM
2 stops8h 45m
Southwest
Deal found 4/17![Southwest logo]()
$340
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Mon 5/186:08 am
SAT
- DSM
1 stop6h 16m
Delta
Deal found 4/16![Delta logo]()
$350
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:15 pm
DSM
- SAT
1 stop8h 35m
Southwest
Fri 6/52:10 pm
SAT
- DSM
2 stops9h 20m
Southwest
Deal found 4/20![Southwest logo]()
$357
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:02 pm
DSM
- SAT
1 stop4h 04m
American Airlines
Thu 6/115:00 am
SAT
- DSM
1 stop4h 11m
American Airlines
Deal found 4/20![American Airlines logo]()
$361
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:01 pm
DSM
- SAT
1 stop4h 05m
American Airlines
Thu 5/286:04 am
SAT
- DSM
1 stop7h 14m
American Airlines
Deal found 4/21![American Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:02 pm
DSM
- SAT
1 stop8h 57m
American Airlines
Mon 5/187:12 pm
SAT
- DSM
1 stop4h 47m
American Airlines
Deal found 4/17![American Airlines logo]()
$365
Best flights from Des Moines to San AntonioDiscover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
Discover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/113:20 pm
DSM
- SAT
1 stop7h 35m
United Airlines
Wed 5/135:34 pm
SAT
- DSM
1 stop5h 50m
United Airlines
Deal found 4/21![United Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1711:28 am
DSM
- SAT
1 stop6h 04m
Delta
Tue 6/236:05 am
SAT
- DSM
1 stop8h 00m
Delta
Deal found 4/16![Delta logo]()
$335
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:55 am
DSM
- SAT
2 stops10h 05m
Southwest
Mon 5/184:25 pm
SAT
- DSM
2 stops6h 40m
Southwest
Deal found 4/16![Southwest logo]()
$398
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Mon 5/186:08 am
SAT
- DSM
1 stop6h 16m
Delta
Deal found 4/16![Delta logo]()
$350
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:25 am
DSM
- SAT
2 stops10h 20m
Southwest
Mon 5/184:25 pm
SAT
- DSM
2 stops6h 40m
Southwest
Deal found 4/17![Southwest logo]()
$406
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Tue 5/266:08 am
SAT
- DSM
1 stop6h 16m
Delta
Deal found 4/17![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:20 pm
DSM
- SAT
1 stop8h 10m
Southwest
Wed 5/131:25 pm
SAT
- DSM
2 stops7h 50m
Southwest
Deal found 4/21![Southwest logo]()
$408
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:39 pm
DSM
- SAT
1 stop5h 51m
Delta
Mon 6/296:05 am
SAT
- DSM
1 stop8h 00m
Delta
Deal found 4/20![Delta logo]()
$407
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:45 am
DSM
- SAT
1 stop5h 25m
Delta
Fri 8/214:25 pm
SAT
- DSM
1 stop6h 01m
Delta
Deal found 4/18![Delta logo]()
$407
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/236:30 pm
DSM
- SAT
1 stop5h 45m
Delta
Tue 8/2512:15 pm
SAT
- DSM
1 stop5h 27m
Delta
Deal found 4/18![Delta logo]()
$407
Last-minute flights from Des Moines to San AntonioDiscover last-minute flight deals from Des Moines to San Antonio. Data last updated April 21, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Antonio. Data last updated April 21, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:33 pm
DSM
- SAT
1 stop7h 58m
Delta
Tue 5/125:00 pm
SAT
- DSM
1 stop5h 32m
Delta
Deal found 4/20![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:20 pm
DSM
- SAT
1 stop8h 10m
Southwest
Tue 5/122:00 pm
SAT
- DSM
1 stop7h 15m
Southwest
Deal found 4/20![Southwest logo]()
$305
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Wed 5/132:35 pm
SAT
- DSM
1 stop6h 37m
Delta
Deal found 4/21![Delta logo]()
$326
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Mon 5/186:08 am
SAT
- DSM
1 stop6h 16m
Delta
Deal found 4/16![Delta logo]()
$350
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:02 pm
DSM
- SAT
1 stop8h 57m
American Airlines
Mon 5/187:12 pm
SAT
- DSM
1 stop4h 47m
American Airlines
Deal found 4/17![American Airlines logo]()
$365
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/144:20 pm
DSM
- SAT
1 stop8h 10m
Southwest
Mon 5/184:25 pm
SAT
- DSM
2 stops6h 40m
Southwest
Deal found 4/17![Southwest logo]()
$370
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:15 am
DSM
- SAT
1 stop7h 28m
United Airlines
Tue 5/198:48 am
SAT
- DSM
1 stop7h 27m
United Airlines
Deal found 4/20![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Sat 5/2312:08 pm
SAT
- DSM
1 stop8h 14m
Delta
Deal found 4/19![Delta logo]()
$382
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:01 pm
DSM
- SAT
1 stop4h 05m
American Airlines
Thu 5/286:04 am
SAT
- DSM
1 stop7h 14m
American Airlines
Deal found 4/21![American Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/214:20 pm
DSM
- SAT
1 stop8h 10m
Southwest
Thu 5/284:25 pm
SAT
- DSM
2 stops6h 40m
Southwest
Deal found 4/21![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:41 pm
DSM
- SAT
1 stop6h 03m
Delta
Tue 5/266:08 am
SAT
- DSM
1 stop6h 16m
Delta
Deal found 4/17![Delta logo]()
$371
One-way flights from Des Moines to San AntonioSearch for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
Search for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
This CheapOair deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- SAT
1 stop25h 05m
Frontier
Deal found 4/16![Frontier logo]()
$123
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:25 pm
DSM
- SAT
1 stop5h 07m
Delta
Deal found 4/20![Delta logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:07 pm
DSM
- SAT
2 stops22h 06m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:59 pm
DSM
- SAT
3 stops50h 57m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- SAT
2 stops47h 33m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:16 pm
DSM
- SAT
1 stop28h 40m
Frontier
Deal found 4/18![Frontier logo]()
$200
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:39 pm
DSM
- SAT
1 stop5h 51m
Delta
Deal found 4/18![Delta logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:49 pm
DSM
- SAT
2 stops29h 07m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:40 pm
DSM
- SAT
2 stops23h 33m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:35 am
DSM
- SAT
2 stops9h 15m
Southwest
Deal found 4/20![Southwest logo]()
$209
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/52:45 pm
DSM
- SAT
1 stop6h 47m
Delta
Deal found 4/18![Delta logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:22 pm
DSM
- SAT
2 stops42h 28m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$223
Find flight deals from Des Moines to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $305 (Southwest) |
One-way from | $123 (CheapOair) |
Popular in | March |
Cheapest in | August |
Average price | $370 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Mon 5/11
3:20 pm-10:55 pm
1 stop7h 35m
San Antonio
Wed 5/13
5:34 pm-11:24 pm
1 stop5h 50m
$326
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 6/17
11:28 am-5:32 pm
1 stop6h 04m
San Antonio
Tue 6/23
6:05 am-2:05 pm
1 stop8h 00m
$335
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 5/13
6:41 pm-12:44 am
1 stop6h 03m
San Antonio
Mon 5/18
6:08 am-12:24 pm
1 stop6h 16m
$350
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 5/22
6:41 pm-12:44 am
1 stop6h 03m
San Antonio
Tue 5/26
6:08 am-12:24 pm
1 stop6h 16m
$371
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 5/13
6:55 am-5:00 pm
2 stops10h 05m
San Antonio
Mon 5/18
4:25 pm-11:05 pm
2 stops6h 40m
$398
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Thu 5/14
5:25 am-3:45 pm
2 stops10h 20m
San Antonio
Mon 5/18
4:25 pm-11:05 pm
2 stops6h 40m
$406
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Mon 6/22
6:39 pm-12:30 am
1 stop5h 51m
San Antonio
Mon 6/29
6:05 am-2:05 pm
1 stop8h 00m
$407
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 8/21
5:45 am-11:10 am
1 stop5h 25m
San Antonio
Fri 8/21
4:25 pm-10:26 pm
1 stop6h 01m
$407
Quickest round-trip
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sun 8/23
6:30 pm-12:15 am
1 stop5h 45m
San Antonio
Tue 8/25
12:15 pm-5:42 pm
1 stop5h 27m
$407
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Mon 5/11
4:20 pm-12:30 am
1 stop8h 10m
San Antonio
Wed 5/13
1:25 pm-9:15 pm
2 stops7h 50m
$408
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
DSM-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Antonio
How far ahead should I book a flight from Des Moines to San Antonio?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Antonio. Price data was last updated on April 17, 2026.
The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Antonio?
Currently, August is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $324). Flying from Des Moines to San Antonio in March is currently the most expensive (average of $587). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Antonio?
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated April 21, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Des Moines and San Antonio flights
Browse other Des Moines and San Antonio flight options. Last updated on April 21, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 21, 2026.
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Other flights to San Antonio
Explore flights to San Antonio departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 21, 2026.
Top 4 airlines flying from Des Moines to San Antonio
Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$406 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$369 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$299 | Average$436 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$327 | Average$421 | FlexibilityNo cancel fee | On-time63% |