$214+ Cheap flights from Des Moines to San Antonio (DSM - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
Feb 21 — Feb 281
1 adult, Economy
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Find cheap flights from Des Moines to San Antonio with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Antonio
Cheapest flights from Des Moines to San AntonioExplore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 22, 2026.
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 22, 2026.
This Expedia deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- SAT
1 stop26h 56m
Frontier
Sat 3/146:45 am
SAT
- DSM
1 stop12h 31m
Frontier
Deal found 1/21![Frontier logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:21 pm
DSM
- SAT
1 stop27h 56m
Multiple Airlines
Thu 4/210:27 am
SAT
- DSM
1 stop12h 24m
Multiple Airlines
Deal found 1/20![Multiple Airlines logo]()
$279
This Mytrip deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/127:32 pm
DSM
- SAT
1 stop24h 05m
Frontier
Sat 2/147:56 pm
SAT
- DSM
1 stop22h 36m
Frontier
Deal found 1/20![Frontier logo]()
$280
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/114:00 pm
DSM
- SAT
1 stop6h 58m
American Airlines
Sat 2/145:17 am
SAT
- DSM
1 stop7h 48m
American Airlines
Deal found 1/20![American Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/34:20 pm
DSM
- SAT
1 stop5h 17m
Delta
Tue 3/105:10 am
SAT
- DSM
1 stop5h 38m
Delta
Deal found 1/21![Delta logo]()
$318
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:25 pm
DSM
- SAT
1 stop5h 22m
Delta
Tue 3/175:10 am
SAT
- DSM
1 stop5h 38m
Delta
Deal found 1/20![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:26 pm
DSM
- SAT
1 stop7h 28m
American Airlines
Sat 2/284:47 pm
SAT
- DSM
2 stops6h 53m
American Airlines
Deal found 1/20![American Airlines logo]()
$323
This Southwest deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:40 am
DSM
- SAT
1 stop7h 30m
Southwest
Tue 3/176:20 am
SAT
- DSM
2 stops6h 55m
Southwest
Deal found 1/20![Southwest logo]()
$324
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2111:26 am
DSM
- SAT
1 stop5h 38m
American Airlines
Thu 2/265:00 pm
SAT
- DSM
1 stop6h 40m
American Airlines
Deal found 1/20![American Airlines logo]()
$329
Find flight deals from Des Moines to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 22, 2026.
Most accurate provider | Mytrip 3 stars |
|---|---|
Most trusted provider | Mytrip 3 stars |
Round-trip from | $259 (Expedia) |
One-way from | $214 (Kiwi.com) |
Popular in | March |
Cheapest in | August |
Average price | $424 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.
Fly from
Des Moines
Fly to
San Antonio
Route
Depart
Return
Price
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Mon 3/30
8:21 pm-12:17 am
1 stop27h 56m
San Antonio
Thu 4/2
10:27 am-10:51 pm
1 stop12h 24m
$279
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 2/11
4:00 pm-10:58 pm
1 stop6h 58m
San Antonio
Sat 2/14
5:17 am-1:05 pm
1 stop7h 48m
$317
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 3/3
4:20 pm-9:37 pm
1 stop5h 17m
San Antonio
Tue 3/10
5:10 am-10:48 am
1 stop5h 38m
$318
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 3/10
6:40 am-3:45 pm
2 stops9h 05m
San Antonio
Tue 3/17
5:35 am-1:15 pm
2 stops7h 40m
$330
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 3/7
5:05 am-9:33 am
1 stop4h 28m
San Antonio
Wed 3/11
5:36 pm-11:42 pm
1 stop6h 06m
$330
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 5/2
5:45 am-12:44 pm
1 stop6h 59m
San Antonio
Tue 5/5
11:50 am-8:39 pm
1 stop8h 49m
$330
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 3/4
5:30 am-1:08 pm
2 stops7h 38m
San Antonio
Mon 3/9
7:00 am-1:23 pm
1 stop6h 23m
$334
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 5/2
6:00 am-12:42 pm
2 stops6h 42m
San Antonio
Tue 5/5
5:45 pm-11:16 pm
1 stop5h 31m
$335
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 4/22
3:04 pm-9:03 pm
1 stop5h 59m
San Antonio
Mon 4/27
6:02 pm-10:43 pm
1 stop4h 41m
$341
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 3/14
8:21 pm-9:06 am
1 stop12h 45m
$214
Showing 1-10 of 13 results
Compare providers for flights from Des Moines to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in January.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Antonio
How far ahead should I book a flight from Des Moines to San Antonio?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Antonio. Price data was last updated on January 16, 2026.
The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Antonio?
Currently, July is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $83). Flying from Des Moines to San Antonio in November is currently the most expensive (average of $142). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated January 22, 2026.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Alternative routes for Des Moines to San Antonio
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to San Antonio
Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$270 | Average$386 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$299 | Average$456 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$327 | Average$382 | FlexibilityNo cancel fee | On-time63% |