$135+ Cheap flights from Des Moines to San Antonio (DSM - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
Jan 7 — Jan 141
1 adult, Economy
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Find cheap flights from Des Moines to San Antonio with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to San Antonio are usually found in August or July, booked 47 days in advance, depart on a Wednesday or Thursday and return on a Tuesday
Cheap flight deals from Des Moines to San Antonio
Cheapest flights from Des Moines to San AntonioExplore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.
This Priceline deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/302:35 pmDSM - SAT
1 stop9h 42mFrontier
Mon 1/512:18 pmSAT - DSM
1 stop7h 26mFrontier
Deal found 12/6![Frontier logo]()
$242
This Booking.com deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:29 pmDSM - SAT
1 stop14h 52mFrontier
Fri 1/910:13 amSAT - DSM
1 stop9h 09mFrontier
Deal found 12/5![Frontier logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:54 pmDSM - SAT
2 stops28h 23mMultiple Airlines
Fri 1/910:13 amSAT - DSM
1 stop9h 09mMultiple Airlines
Deal found 12/5![Multiple Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/252:07 pmDSM - SAT
1 stop6h 01mAmerican Airlines
Tue 12/306:44 amSAT - DSM
1 stop4h 03mAmerican Airlines
Deal found 12/8![American Airlines logo]()
$365
This Kiwi.com deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:31 amDSM - SAT
2 stops14h 55mMultiple Airlines
Mon 12/2912:18 pmSAT - DSM
1 stop7h 26mMultiple Airlines
Deal found 12/7![Multiple Airlines logo]()
$378
This Gotogate deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:29 pmDSM - SAT
1 stop14h 52mFrontier
Fri 1/26:45 amSAT - DSM
1 stop12h 59mFrontier
Deal found 12/6![Frontier logo]()
$379
This Booking.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:29 pmDSM - SAT
1 stop14h 52mFrontier
Tue 12/236:45 amSAT - DSM
1 stop6h 55mFrontier
Deal found 12/8![Frontier logo]()
$381
This American Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:40 amDSM - SAT
1 stop6h 27mAmerican Airlines
Sat 12/276:00 amSAT - DSM
1 stop4h 47mAmerican Airlines
Deal found 12/8![American Airlines logo]()
$396
This American Airlines deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:40 amDSM - SAT
1 stop6h 27mAmerican Airlines
Mon 12/296:00 amSAT - DSM
1 stop4h 49mAmerican Airlines
Deal found 12/6![American Airlines logo]()
$404
This Southwest deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:50 pmDSM - SAT
1 stop5h 25mSouthwest
Sun 1/45:00 amSAT - DSM
1 stop6h 00mSouthwest
Deal found 12/7![Southwest logo]()
$407
Find flight deals from Des Moines to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 8, 2025.
Most accurate provider | Mytrip 3 stars |
|---|---|
Most trusted provider | Mytrip 3 stars |
Round-trip from | $229 (Kiwi.com) |
One-way from | $135 (American Airlines) |
Popular in | March |
Cheapest in | August |
Average price | $406 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 8, 2025.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.
Fly from
Des Moines
Fly to
San Antonio
Route
Depart
Return
Price
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 12/30
2:35 pm-12:17 am
1 stop9h 42m
San Antonio
Mon 1/5
12:18 pm-7:44 pm
1 stop7h 26m
$242
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 2/14
3:24 pm-11:12 pm
1 stop7h 48m
San Antonio
Wed 2/18
6:03 pm-10:20 pm
1 stop4h 17m
$269
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 2/21
3:26 pm-10:53 pm
1 stop7h 27m
San Antonio
Sat 2/28
5:00 am-10:47 am
1 stop5h 47m
$292
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 1/20
5:16 pm-12:38 am
1 stop7h 22m
San Antonio
Tue 1/27
2:42 pm-9:24 pm
1 stop6h 42m
$293
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 12/19
8:29 pm-11:21 am
1 stop14h 52m
San Antonio
Fri 1/9
10:13 am-7:22 pm
1 stop9h 09m
$310
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 1/21
5:16 pm-12:38 am
1 stop7h 22m
San Antonio
Wed 1/28
10:45 am-4:28 pm
1 stop5h 43m
$317
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 1/28
1:35 pm-8:44 pm
1 stop7h 09m
San Antonio
Sat 1/31
2:05 pm-9:50 pm
1 stop7h 45m
$317
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 1/14
11:26 am-5:15 pm
1 stop5h 49m
San Antonio
Wed 1/21
8:00 am-4:28 pm
1 stop8h 28m
$317
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Wed 1/7
3:20 pm-11:05 pm
2 stops7h 45m
San Antonio
Wed 1/14
10:15 am-9:10 pm
1 stop10h 55m
$328
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 1/20
5:51 pm-10:58 pm
1 stop5h 07m
$135
Showing 1-10 of 16 results
Compare providers for flights from Des Moines to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in December.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Antonio
How far ahead should I book a flight from Des Moines to San Antonio?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Antonio. Price data was last updated on December 5, 2025.
The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 47 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Antonio?
Currently, July is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $83). Flying from Des Moines to San Antonio in November is currently the most expensive (average of $142). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to SAT?
Find hourly flight availability from Des Moines to San Antonio. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 8, 2025.
One of the essential ways to save on airfare from Des Moines to San Antonio is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 25% on airfare.
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated December 8, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Comfort
8.0
Food
7.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
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Alternative routes for Des Moines to San Antonio
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to San Antonio
Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 8, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$271 | Average$405 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$283 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$296 | Average$452 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$327 | Average$421 | FlexibilityNo cancel fee | On-time63% |