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$157+ Cheap flights from Des Moines to San Antonio (DSM - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
Dec 24 — Dec 311
Wed 12/24
Wed 12/31
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Des Moines to San Antonio are usually found in August or July, booked 47 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Find flight deals from Des Moines to San Antonio

Cheapest flights from Des Moines to San Antonio
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 24, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/44:21 pmDSM - SAT
2 stops28h 09mMultiple Airlines
Thu 12/117:56 pmSAT - DSM
1 stop23h 07mMultiple Airlines
Deal found 11/22$287
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:53 pmDSM - SAT
1 stop23h 39mMultiple Airlines
Sun 12/147:56 pmSAT - DSM
1 stop23h 07mMultiple Airlines
Deal found 11/23$318
This Mytrip deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - SAT
1 stop8h 30mMultiple Airlines
Thu 12/182:39 pmSAT - DSM
1 stop7h 57mMultiple Airlines
Deal found 11/22$327
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:32 amDSM - SAT
1 stop6h 25mAmerican Airlines
Tue 12/305:48 pmSAT - DSM
1 stop6h 49mAmerican Airlines
Deal found 11/24$368
This Kiwi.com deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:29 pmDSM - SAT
1 stop14h 52mMultiple Airlines
Sat 12/2712:18 pmSAT - DSM
2 stops22h 42mMultiple Airlines
Deal found 11/22$393
This American Airlines deal was found by Cheapflights users on 11/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:56 pmDSM - SAT
1 stop6h 34mAmerican Airlines
Sat 12/276:00 amSAT - DSM
1 stop4h 47mAmerican Airlines
Deal found 11/22$395
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:56 pmDSM - SAT
1 stop6h 34mAmerican Airlines
Tue 12/305:00 amSAT - DSM
1 stop5h 47mAmerican Airlines
Deal found 11/24$397

Cheap flight deals from Des Moines to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 24, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$160
(Kiwi.com)

One-way from

$157
(American Airlines)

Popular in

June

Cheapest in

August

Average price

$383
Provider with most accurate pricing for Des Moines-San Antonio flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-San Antonio flights.
Search Deals
From Des Moines to San Antonio
Search Deals
One-way flight from Des Moines to San Antonio
Search Deals
High demand for flights, 2% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 24, 2025.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Des Moines

Fly to

San Antonio

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 2/12

7:36 pm-9:18 am

1 stop13h 42m

San Antonio

Thu 2/19

10:13 am-6:41 pm

1 stop8h 28m

$160

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 1/8

8:30 am-11:49 am

1 stop27h 19m

San Antonio

Thu 1/15

10:35 am-10:46 pm

1 stop12h 11m

$229

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 1/26

11:09 am-11:52 pm

2 stops12h 43m

San Antonio

Thu 1/29

2:06 pm-3:40 pm

1 stop25h 34m

$268

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 1/6

4:00 pm-10:58 pm

1 stop6h 58m

San Antonio

Tue 1/13

7:00 am-10:50 am

1 stop3h 50m

$288

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Tue 1/6

5:16 pm-11:23 pm

1 stop6h 07m

San Antonio

Tue 1/13

2:42 pm-9:24 pm

1 stop6h 42m

$289

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sat 2/7

3:04 pm-7:41 pm

1 stop4h 37m

San Antonio

Thu 2/12

2:10 pm-9:51 pm

1 stop7h 41m

$289

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 1/5

5:39 pm-9:50 pm

1 stop4h 11m

San Antonio

Tue 1/13

4:40 pm-11:23 pm

1 stop6h 43m

$289

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Sat 2/21

6:45 am-12:23 pm

1 stop5h 38m

San Antonio

Wed 2/25

4:29 pm-10:31 pm

1 stop6h 02m

$289

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Thu 12/4

2:56 pm-11:26 pm

1 stop8h 30m

San Antonio

Thu 12/18

2:39 pm-10:36 pm

1 stop7h 57m

$327

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

Mon 1/5

5:45 am-12:10 pm

1 stop6h 25m

San Antonio

Tue 1/13

10:10 am-7:20 pm

2 stops9h 10m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/22

Showing 1-10 of 19 results
1
2

Compare providers for flights from Des Moines to San Antonio

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Antonio

How far ahead should I book a flight from Des Moines to San Antonio?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Antonio. Price data was last updated on November 21, 2025.

The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 47 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to San Antonio?

Currently, July is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $83). Flying from Des Moines to San Antonio in November is currently the most expensive (average of $143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SAT?

Find hourly flight availability from Des Moines to San Antonio. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 24, 2025.

One of the essential ways to save on airfare from Des Moines to San Antonio is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 25% on airfare.

Reviews of airlines servicing San Antonio

Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated November 24, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,252 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,252 reviews
Southwest
8.0
Very good
4,252 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,998 reviews
Southwest
8.0
Very good
4,252 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,044 reviews
Southwest
8.0
Very good
4,252 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,042 reviews
Southwest
8.0
Very good
4,252 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to San Antonio?

    A quick flight from Des Moines to San Antonio can take about 6h 07m. Frontier provides one of the quickest options available for as low as $289. The distance from Des Moines to San Antonio is about 872 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to San Antonio round-trip?

    Currently priced at $280, American Airlines will fly you from Des Moines to San Antonio and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $283 and $299, respectively. These flights start at 30% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to San Antonio that include hotel bookings?

    Yes. In addition to deals on Des Moines to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Antonio.

  • Can I find deals for business class flights from Des Moines to San Antonio?

    Yes. Cheapflights offers flight deals from Des Moines to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to San Antonio?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $83). Flying from Des Moines to San Antonio in November is currently the most expensive (average of $143). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to San Antonio

Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$280Average$413FlexibilityNo cancel feeOn-time71%
DeltaCheapest$283Average$365FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$299Average$454FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$327Average$382FlexibilityNo cancel feeOn-time63%

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