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$123+ Cheap flights from Des Moines to San Antonio (DSM - SAT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
oct. 17 — oct. 241
ven. 10/17
ven. 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to San Antonio are usually found in August or July, booked 63 days in advance, depart on a Wednesday or Thursday and return on a Tuesday

Cheap flight deals from Des Moines to San Antonio

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septembre 17, 2025.

Round-trip from

$228
(Kiwi.com)

One-way from

$123
(Kiwi.com)

Popular in

September

Cheapest in

August

Average price

$485
From Des Moines to San Antonio
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One-way flight from Des Moines to San Antonio
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to San Antonio

Cheapest flights from Des Moines to San Antonio
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septembre 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven. 10/312:32 pmDSM - SAT
1 stop23h 45mMultiple Airlines
ven. 11/712:17 pmSAT - DSM
1 stop10h 23mMultiple Airlines
Deal found 9/15$228
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/87:30 amDSM - SAT
1 stop16h 10mMultiple Airlines
mer. 10/157:00 amSAT - DSM
1 stop7h 27mMultiple Airlines
Deal found 9/15$238
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/62:32 pmDSM - SAT
1 stop28h 58mFrontier
dim. 11/910:46 pmSAT - DSM
2 stops15h 01mFrontier
Deal found 9/15$251
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/811:06 amDSM - SAT
1 stop6h 11mDelta
mer. 10/152:31 pmSAT - DSM
1 stop6h 32mDelta
Deal found 9/16$297
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 11/610:50 amDSM - SAT
1 stop28h 21mMultiple Airlines
dim. 11/98:25 pmSAT - DSM
1 stop17h 22mMultiple Airlines
Deal found 9/15$302
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jeu. 10/3010:00 amDSM - SAT
1 stop5h 56mDelta
mar. 11/410:54 amSAT - DSM
1 stop6h 50mDelta
Deal found 9/16$305
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/293:30 pmDSM - SAT
1 stop29h 22mMultiple Airlines
mer. 10/19:47 pmSAT - DSM
1 stop24h 53mMultiple Airlines
Deal found 9/15$314
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 11/52:40 pmDSM - SAT
1 stop6h 30mDelta
ven. 11/72:31 pmSAT - DSM
1 stop6h 32mDelta
Deal found 9/15$321
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 10/83:00 pmDSM - SAT
2 stops8h 00mSouthwest
mer. 10/1512:45 pmSAT - DSM
2 stops9h 05mSouthwest
Deal found 9/15$342

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septembre 17, 2025.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.

Fly from

Des Moines

Fly to

San Antonio

Route

Depart

Return

Price

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mer. 10/8

7:30 am-11:40 pm

1 stop16h 10m

San Antonio

mer. 10/15

7:00 am-2:27 pm

1 stop7h 27m

$238

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jeu. 11/6

2:32 pm-7:30 pm

1 stop28h 58m

San Antonio

dim. 11/9

10:46 pm-1:47 pm

2 stops15h 01m

$251

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jeu. 10/30

2:32 pm-7:30 pm

1 stop28h 58m

San Antonio

jeu. 11/6

6:23 pm-10:40 pm

1 stop28h 17m

$251

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mer. 10/8

11:06 am-5:17 pm

1 stop6h 11m

San Antonio

mer. 10/15

2:31 pm-9:03 pm

1 stop6h 32m

$297

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jeu. 11/6

10:50 am-3:11 pm

1 stop28h 21m

San Antonio

dim. 11/9

8:25 pm-1:47 pm

1 stop17h 22m

$302

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jeu. 10/30

2:40 pm-9:10 pm

1 stop6h 30m

San Antonio

mar. 11/4

5:14 am-1:28 pm

1 stop8h 14m

$305

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

sam. 10/18

11:31 am-7:30 pm

2 stops7h 59m

San Antonio

mer. 10/22

5:56 pm-10:28 pm

1 stop4h 32m

$310

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

mer. 11/5

2:40 pm-9:10 pm

1 stop6h 30m

San Antonio

ven. 11/7

2:31 pm-9:03 pm

1 stop6h 32m

$321

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

ven. 11/14

2:34 pm-2:17 pm

1 stop23h 43m

$123

Des MoinesSan Antonio

DSM - SAT

DSMSAT

Des Moines

jeu. 11/13

2:32 pm-7:30 pm

1 stop28h 58m

$123

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 20 results
1
2

Best time to book a flight from Des Moines to San Antonio

Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to San Antonio

How far ahead should I book a flight from Des Moines to San Antonio?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to San Antonio. Price data was last updated on September 12, 2025.

The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 63 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to San Antonio?

Currently, August is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $295). Flying from Des Moines to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SAT?

Find hourly flight availability from Des Moines to San Antonio. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septembre 17, 2025.

One of the essential ways to save on airfare from Des Moines to San Antonio is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 26% on airfare.

Reviews of airlines servicing San Antonio

Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated septembre 17, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,961 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to San Antonio?

    A quick flight from Des Moines to San Antonio can take about 28h 58m. Frontier provides one of the quickest options available for as low as $251. The distance from Des Moines to San Antonio is about 872 mi.

  • What are the cheapest airlines flying from Des Moines to San Antonio round-trip?

    Currently priced at $276, American Airlines will fly you from Des Moines to San Antonio and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $283 and $302, respectively. These flights start at 31% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to San Antonio that include hotel bookings?

    Yes. In addition to deals on Des Moines to San Antonio flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to San Antonio?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to San Antonio.

  • Can I find deals for business class flights from Des Moines to San Antonio?

    Yes. Cheapflights offers flight deals from Des Moines to San Antonio by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to San Antonio?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $295). Flying from Des Moines to San Antonio in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Antonio?

Book flights to San Antonio if you plan to visit one of these locations
New Braunfels
Kerrville

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Alternative routes for Des Moines to San Antonio

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to San Antonio

Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$276Average$397FlexibilityNo cancel feeOn-time71%
DeltaCheapest$283Average$361FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$302Average$452FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$327Average$382FlexibilityNo cancel feeOn-time63%

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