$214+ Cheap flights from St. Louis to Roanoke (STL - ROA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/12. Fares are subject to change and may not be available on all flights or dates of travel.
STL — ROA
Jun 22 — Jun 291
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from St. Louis to Roanoke with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Roanoke
Cheapest
Best
Last-minute
One-way
Cheapest flights from St. Louis to RoanokeExplore the most affordable flight options available from St. Louis to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2026.
Explore the most affordable flight options available from St. Louis to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 23, 2026.
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:15 am
STL
- ROA
1 stop7h 09m
American Airlines
Mon 6/297:58 pm
ROA
- STL
1 stop4h 46m
American Airlines
Deal found 5/19![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:30 pm
STL
- ROA
1 stop4h 46m
Delta
Sun 9/276:00 am
ROA
- STL
1 stop5h 41m
Delta
Deal found 5/18![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:01 pm
STL
- ROA
1 stop4h 33m
Delta
Mon 6/87:59 pm
ROA
- STL
1 stop4h 57m
Delta
Deal found 5/21![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/279:24 am
STL
- ROA
1 stop5h 48m
American Airlines
Tue 6/307:58 pm
ROA
- STL
1 stop4h 46m
American Airlines
Deal found 5/21![American Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:13 am
STL
- ROA
1 stop6h 16m
American Airlines
Sun 10/186:00 am
ROA
- STL
1 stop7h 24m
American Airlines
Deal found 5/18![American Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:00 pm
STL
- ROA
1 stop5h 58m
Delta
Tue 6/307:59 pm
ROA
- STL
1 stop4h 57m
Delta
Deal found 5/21![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:13 pm
STL
- ROA
1 stop4h 46m
American Airlines
Sun 6/215:00 am
ROA
- STL
1 stop4h 32m
American Airlines
Deal found 5/19![American Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:01 pm
STL
- ROA
1 stop4h 33m
Delta
Sun 5/246:00 am
ROA
- STL
1 stop4h 49m
Delta
Deal found 5/22![Delta logo]()
$403
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:14 am
STL
- ROA
1 stop4h 31m
American Airlines
Tue 6/306:16 pm
ROA
- STL
2 stops7h 00m
American Airlines
Deal found 5/21![American Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:01 pm
STL
- ROA
1 stop4h 33m
Delta
Mon 6/87:59 pm
ROA
- STL
1 stop4h 57m
Delta
Deal found 5/20![Delta logo]()
$413
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:25 am
STL
- ROA
1 stop4h 46m
United Airlines
Sat 5/302:45 pm
ROA
- STL
1 stop4h 29m
United Airlines
Deal found 5/21![United Airlines logo]()
$414
Best flights from St. Louis to RoanokeDiscover carefully curated flight deals from St. Louis to Roanoke that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 23, 2026.
Discover carefully curated flight deals from St. Louis to Roanoke that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 23, 2026.
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:17 am
STL
- ROA
1 stop4h 34m
Delta
Sun 8/307:59 pm
ROA
- STL
1 stop4h 59m
Delta
Deal found 5/22![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:59 pm
STL
- ROA
1 stop6h 55m
United Airlines
Wed 9/25:51 pm
ROA
- STL
1 stop5h 09m
United Airlines
Deal found 5/18![United Airlines logo]()
$472
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:00 am
STL
- ROA
1 stop4h 40m
Delta
Sat 10/107:50 pm
ROA
- STL
1 stop4h 49m
Delta
Deal found 5/20![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:30 pm
STL
- ROA
1 stop4h 46m
Delta
Sun 9/276:00 am
ROA
- STL
1 stop5h 41m
Delta
Deal found 5/18![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:01 pm
STL
- ROA
1 stop4h 33m
Delta
Mon 6/87:59 pm
ROA
- STL
1 stop4h 57m
Delta
Deal found 5/21![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:01 pm
STL
- ROA
1 stop4h 33m
Delta
Mon 6/87:59 pm
ROA
- STL
1 stop4h 57m
Delta
Deal found 5/20![Delta logo]()
$413
Last-minute flights from St. Louis to RoanokeDiscover last-minute flight deals from St. Louis to Roanoke. Data last updated May 23, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Roanoke. Data last updated May 23, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:01 pm
STL
- ROA
1 stop4h 33m
Delta
Sun 5/246:00 am
ROA
- STL
1 stop4h 49m
Delta
Deal found 5/22![Delta logo]()
$403
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:01 pm
STL
- ROA
1 stop4h 33m
Delta
Mon 5/257:30 pm
ROA
- STL
1 stop5h 29m
Delta
Deal found 5/21![Delta logo]()
$429
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:00 pm
STL
- ROA
1 stop5h 58m
Delta
Tue 6/307:59 pm
ROA
- STL
1 stop4h 57m
Delta
Deal found 5/21![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:14 am
STL
- ROA
1 stop4h 31m
American Airlines
Tue 6/306:16 pm
ROA
- STL
2 stops7h 00m
American Airlines
Deal found 5/21![American Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:25 am
STL
- ROA
1 stop4h 46m
United Airlines
Sat 5/302:45 pm
ROA
- STL
1 stop4h 29m
United Airlines
Deal found 5/21![United Airlines logo]()
$414
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/239:09 am
STL
- ROA
1 stop5h 55m
American Airlines
Sat 5/307:58 pm
ROA
- STL
1 stop4h 46m
American Airlines
Deal found 5/21![American Airlines logo]()
$452
This American Airlines deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/279:24 am
STL
- ROA
1 stop5h 48m
American Airlines
Tue 6/307:58 pm
ROA
- STL
1 stop4h 46m
American Airlines
Deal found 5/21![American Airlines logo]()
$343
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:01 pm
STL
- ROA
1 stop4h 33m
Delta
Mon 6/87:59 pm
ROA
- STL
1 stop4h 57m
Delta
Deal found 5/20![Delta logo]()
$413
This Delta deal was found by Cheapflights users on 5/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:01 pm
STL
- ROA
1 stop4h 33m
Delta
Mon 6/87:59 pm
ROA
- STL
1 stop4h 57m
Delta
Deal found 5/21![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:13 pm
STL
- ROA
1 stop4h 46m
American Airlines
Sun 6/215:00 am
ROA
- STL
1 stop4h 32m
American Airlines
Deal found 5/19![American Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:15 am
STL
- ROA
1 stop7h 09m
American Airlines
Mon 6/297:58 pm
ROA
- STL
1 stop4h 46m
American Airlines
Deal found 5/19![American Airlines logo]()
$309
One-way flights from St. Louis to RoanokeSearch for one-way flight options from St. Louis to Roanoke. Find affordable one-way fares based on user searches. Data last updated May 23, 2026.
Search for one-way flight options from St. Louis to Roanoke. Find affordable one-way fares based on user searches. Data last updated May 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:33 pm
STL
- ROA
2 stops20h 17m
Multiple Airlines
Deal found 5/19![Multiple Airlines logo]()
$214
This American Airlines deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/159:22 am
STL
- ROA
1 stop6h 54m
American Airlines
Deal found 5/18![American Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:51 am
STL
- ROA
2 stops11h 40m
Delta
Deal found 5/18![Delta logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 5/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:09 pm
STL
- ROA
3 stops20h 57m
Multiple Airlines
Deal found 5/18![Multiple Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1611:18 am
STL
- ROA
2 stops11h 13m
Delta
Deal found 5/22![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/161:13 pm
STL
- ROA
3 stops23h 42m
United Airlines
Deal found 5/22![United Airlines logo]()
$682
Find flight deals from St. Louis to Roanoke
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Roanoke (ROA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $309 (American Airlines) |
One-way from | $214 (Kiwi.com) |
Popular in | March |
Cheapest in | July |
Average price | $536 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
Use the filters below to find and compare flights from St. Louis to Roanoke that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Fri 8/21
9:17 am-2:51 pm
1 stop4h 34m
Roanoke
Sun 8/30
7:59 pm-11:58 pm
1 stop4h 59m
$309
Quickest round-trip
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Tue 10/6
9:00 am-2:40 pm
1 stop4h 40m
Roanoke
Sat 10/10
7:50 pm-11:39 pm
1 stop4h 49m
$329
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Fri 9/25
1:30 pm-7:16 pm
1 stop4h 46m
Roanoke
Sun 9/27
6:00 am-10:41 am
1 stop5h 41m
$329
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Fri 6/5
7:01 pm-12:34 am
1 stop4h 33m
Roanoke
Mon 6/8
7:59 pm-11:56 pm
1 stop4h 57m
$339
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Thu 6/4
7:01 pm-12:34 am
1 stop4h 33m
Roanoke
Mon 6/8
7:59 pm-11:56 pm
1 stop4h 57m
$413
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Sat 8/29
12:59 pm-8:54 pm
1 stop6h 55m
Roanoke
Wed 9/2
5:51 pm-10:00 pm
1 stop5h 09m
$472
Cheapest one-way
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Sun 7/12
6:33 pm-3:50 pm
2 stops20h 17m
$214
Quickest one-way
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Thu 7/16
9:22 am-5:16 pm
1 stop6h 54m
$269
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Wed 7/15
10:51 am-11:31 pm
2 stops11h 40m
$313
St. LouisRoanoke
STL - ROA
STLROA
Lambert-St Louis
Wed 7/15
4:09 pm-2:06 pm
3 stops20h 57m
$362
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Roanoke
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Roanoke in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Roanoke flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Roanoke flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Roanoke flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Roanoke flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Roanoke flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Roanoke
Have a flexible travel schedule? Discover the best time to fly to Roanoke from St. Louis with our price prediction graph.
STL-ROA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Roanoke
Prices
More
What’s the top layover airport for flights from St. Louis to Roanoke?
Share of 1-stop round-trip flights from St. Louis to Roanoke chosen by Cheapflights users in the past 12 months, using the same layover each way.
Charlotte (CLT) – chosen by Cheapflights users on 67% of 1-stop itineraries from St. Louis to Roanoke on Cheapflights.
What’s the cheapest layover airport for flights from St. Louis to Roanoke?
Average round-trip fare for 1-stop flights from St. Louis to Roanoke, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Chicago (ORD) is the most affordable 1-stop option, with an average round-trip price of $328.
What’s the fastest layover option from St. Louis to Roanoke?
Shortest average travel time for 1-stop one-way flights from St. Louis to Roanoke, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Chicago (ORD) have the shortest average one-way travel time for 1-stop routes: 4h 29m.
Which airport typically offers the quickest layover for flights from St. Louis to Roanoke?
Average layover duration for 1-stop one-way flights from St. Louis to Roanoke, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Charlotte (CLT) offer the fastest connection on this route, with an average layover time of 1h 37m.
Reviews of airlines servicing Roanoke
Get insights into the airlines that provide service to Roanoke. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Roanoke. Reviews last updated May 23, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from St. Louis to Roanoke to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Food
7.2
Boarding
8.1
Overall
7.9
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Roanoke?
Book flights to Roanoke if you plan to visit one of these locationsSalem
Radford
Blacksburg
Christiansburg
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from St. Louis
Popular flights
Roanoke flight routes
Alternative routes for St. Louis to Roanoke
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Roanoke by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Roanoke by cabin class
Find flights from St. Louis to Roanoke, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Roanoke flights
Browse other St. Louis and Roanoke flight options. Last updated on May 23, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on May 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Roanoke
Explore flights to Roanoke departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 23, 2026.
Top 3 airlines flying from St. Louis to Roanoke
Discover the top 3 airlines that operate flights from St. Louis to Roanoke. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$196 | Average$377 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$351 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$259 | Average$457 | FlexibilityNo cancel fee | On-time69% |