$274+ Cheap flights from South Carolina to Roanoke (ROA)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — ROA
Dec 3 — Dec 101
Round-trip
1 adult, Economy
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Find cheap flights from South Carolina to Roanoke with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Roanoke
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Cheapest flights from South Carolina to RoanokeExplore the most affordable flight options available from South Carolina to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
Explore the most affordable flight options available from South Carolina to Roanoke. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 3, 2026.
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:34 pm -
1 stop5h 12m
Wed 11/186:10 am -
1 stop5h 13m
Deal found 10/30![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:29 pm -
1 stop3h 09m
Mon 12/74:58 pm -
1 stop4h 15m
Deal found 11/2![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:05 am -
1 stop3h 21m
Sun 11/155:01 am -
1 stop5h 24m
Deal found 10/30![American Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:16 pm -
1 stop3h 30m
Wed 11/186:10 am -
1 stop5h 09m
Deal found 10/29![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:26 pm -
1 stop3h 25m
Mon 11/96:10 am -
1 stop3h 38m
Deal found 10/31![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:58 pm -
1 stop5h 41m
Sun 11/155:01 am -
1 stop5h 26m
Deal found 11/1![American Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:57 pm -
1 stop4h 15m
Wed 12/95:35 am -
1 stop8h 25m
Deal found 11/1![United Airlines logo]()
$401
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:23 am -
1 stop3h 52m
Mon 11/236:00 am -
1 stop4h 06m
Deal found 10/29![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:52 am -
1 stop4h 40m
Sat 11/216:03 pm -
1 stop5h 28m
Deal found 11/2![American Airlines logo]()
$442
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:29 pm -
1 stop3h 09m
Mon 12/76:32 pm -
1 stop4h 19m
Deal found 11/2![American Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:30 am -
1 stop6h 53m
Sun 12/206:16 am -
1 stop3h 52m
Deal found 10/31![United Airlines logo]()
$503
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:10 am -
1 stop3h 15m
Sun 11/296:15 am -
1 stop3h 40m
Deal found 10/29![American Airlines logo]()
$528
Best flights from South Carolina to RoanokeDiscover carefully curated flight deals from South Carolina to Roanoke that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
Discover carefully curated flight deals from South Carolina to Roanoke that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 3, 2026.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:16 pm -
1 stop3h 30m
Wed 11/186:10 am -
1 stop5h 09m
Deal found 10/29![American Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/66:15 am -
1 stop7h 15m
Wed 2/102:05 pm -
1 stop6h 58m
Deal found 10/29![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/234:00 pm -
1 stop6h 50m
Mon 4/2611:20 am -
1 stop4h 00m
Deal found 11/2![Delta logo]()
$562
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:58 pm -
1 stop5h 41m
Sun 11/155:01 am -
1 stop5h 26m
Deal found 11/1![American Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/96:15 am -
1 stop7h 15m
Sat 2/1310:40 am -
1 stop6h 44m
Deal found 10/31![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:57 pm -
1 stop4h 15m
Wed 12/95:35 am -
1 stop8h 25m
Deal found 10/31![United Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:52 am -
1 stop4h 40m
Sat 11/216:03 pm -
1 stop5h 28m
Deal found 11/2![American Airlines logo]()
$442
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:23 am -
1 stop3h 52m
Mon 11/236:00 am -
1 stop4h 06m
Deal found 10/28![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:29 pm -
1 stop3h 09m
Mon 12/76:32 pm -
1 stop4h 19m
Deal found 11/2![American Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:30 am -
1 stop6h 53m
Sun 12/206:16 am -
1 stop3h 52m
Deal found 10/31![United Airlines logo]()
$503
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:00 am -
1 stop4h 37m
Thu 11/196:00 am -
1 stop4h 07m
Deal found 10/31![Delta logo]()
$705
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:05 am -
1 stop3h 20m
Sun 11/295:01 am -
1 stop3h 28m
Deal found 11/1![American Airlines logo]()
$574
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2511:12 am -
2 stops22h 39m
Mon 12/75:35 am -
1 stop8h 25m
Deal found 11/2![United Airlines logo]()
$626
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:54 pm -
1 stop3h 45m
Tue 11/176:00 am -
2 stops9h 44m
Deal found 10/29![American Airlines logo]()
$660
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:35 pm -
2 stops18h 16m
Wed 11/186:30 am -
1 stop7h 26m
Deal found 10/30![United Airlines logo]()
$647
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:00 am -
1 stop7h 26m
Wed 11/188:00 pm -
2 stops13h 30m
Deal found 10/29![United Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:00 am -
2 stops6h 53m
Sun 11/296:15 am -
1 stop3h 40m
Deal found 10/30![American Airlines logo]()
$729
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:52 pm -
1 stop3h 52m
Fri 11/206:00 am -
1 stop4h 06m
Deal found 11/1![United Airlines logo]()
$665
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1712:25 pm -
1 stop6h 28m
Sat 11/216:00 am -
2 stops11h 16m
Deal found 11/2![American Airlines logo]()
$764
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:52 pm -
3 stops25h 09m
Sun 11/156:00 am -
1 stop4h 06m
Deal found 10/30![United Airlines logo]()
$724
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:00 am -
2 stops6h 53m
Thu 11/196:00 am -
1 stop7h 17m
Deal found 10/31![American Airlines logo]()
$989
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:54 pm -
2 stops15h 57m
Sun 11/298:00 pm -
2 stops14h 21m
Deal found 10/30![United Airlines logo]()
$925
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:40 am -
2 stops15h 21m
Sun 11/155:51 pm -
2 stops17h 26m
Deal found 11/1![United Airlines logo]()
$1,981
Last-minute flights from South Carolina to RoanokeDiscover last-minute flight deals from South Carolina to Roanoke. Data last updated November 3, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Roanoke. Data last updated November 3, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:26 pm -
1 stop3h 25m
Mon 11/96:10 am -
1 stop3h 38m
Deal found 10/31![American Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:05 am -
1 stop3h 21m
Sun 11/155:01 am -
1 stop5h 24m
Deal found 10/30![American Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:58 pm -
1 stop5h 41m
Sun 11/155:01 am -
1 stop5h 26m
Deal found 11/1![American Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:34 pm -
1 stop5h 12m
Wed 11/186:10 am -
1 stop5h 13m
Deal found 10/30![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:16 pm -
1 stop3h 30m
Wed 11/186:10 am -
1 stop5h 09m
Deal found 10/29![American Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:52 am -
1 stop4h 40m
Sat 11/216:03 pm -
1 stop5h 28m
Deal found 11/2![American Airlines logo]()
$442
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:23 am -
1 stop3h 52m
Mon 11/236:00 am -
1 stop4h 06m
Deal found 10/29![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:05 am -
1 stop3h 20m
Sun 11/295:01 am -
1 stop3h 28m
Deal found 10/29![American Airlines logo]()
$559
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:10 am -
1 stop3h 15m
Sun 11/296:15 am -
1 stop3h 40m
Deal found 10/29![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:29 pm -
1 stop3h 09m
Mon 12/74:58 pm -
1 stop4h 15m
Deal found 11/2![American Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:29 pm -
1 stop3h 09m
Mon 12/76:32 pm -
1 stop4h 19m
Deal found 11/2![American Airlines logo]()
$459
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:57 pm -
1 stop4h 15m
Wed 12/95:35 am -
1 stop8h 25m
Deal found 11/1![United Airlines logo]()
$401
One-way flights from South Carolina to RoanokeSearch for one-way flight options from South Carolina to Roanoke. Find affordable one-way fares based on user searches. Data last updated November 3, 2026.
Search for one-way flight options from South Carolina to Roanoke. Find affordable one-way fares based on user searches. Data last updated November 3, 2026.
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:19 pm -
1 stop6h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![American Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/189:39 pm -
2 stops22h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Multiple Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1812:40 pm -
2 stops25h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![United Airlines logo]()
$444
Find flight deals from South Carolina to Roanoke
Keep the following information in mind while searching for South Carolina to Roanoke flight deals. Data was last updated November 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $349 (American Airlines) |
One-way from | $274 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
Use the filters below to find and compare flights from South Carolina to Roanoke that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlestonRoanoke
CHS Charleston - ROA Roanoke
CHSROA
Charleston
Thu 3/18
9:39 pm-8:07 pm
2 stops22h 28m
Roanoke
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$364
GreenvilleRoanoke
GSP Greenville - ROA Roanoke
GSPROA
Greenville
Sat 11/14
5:16 pm-8:46 pm
1 stop3h 30m
Roanoke
Wed 11/18
6:10 am-11:19 am
1 stop5h 09m
$381
GreenvilleRoanoke
GSP Greenville - ROA Roanoke
GSPROA
Greenville
Fri 11/13
3:58 pm-9:39 pm
1 stop5h 41m
Roanoke
Sun 11/15
5:01 am-10:27 am
1 stop5h 26m
$391
ColumbiaRoanoke
CAE Columbia Metropolitan - ROA Roanoke
CAEROA
Columbia Metropolitan
Sat 2/6
6:15 am-1:30 pm
1 stop7h 15m
Roanoke
Wed 2/10
2:05 pm-9:03 pm
1 stop6h 58m
$399
ColumbiaRoanoke
CAE Columbia Metropolitan - ROA Roanoke
CAEROA
Columbia Metropolitan
Tue 2/9
6:15 am-1:30 pm
1 stop7h 15m
Roanoke
Sat 2/13
10:40 am-5:24 pm
1 stop6h 44m
$399
CharlestonRoanoke
CHS Charleston - ROA Roanoke
CHSROA
Charleston
Sat 12/5
2:57 pm-7:12 pm
1 stop4h 15m
Roanoke
Wed 12/9
5:35 am-2:00 pm
1 stop8h 25m
$401
CharlestonRoanoke
CHS Charleston - ROA Roanoke
CHSROA
Charleston
Thu 11/19
10:23 am-2:15 pm
1 stop3h 52m
Roanoke
Mon 11/23
6:00 am-10:06 am
1 stop4h 06m
$409
GreenvilleRoanoke
GSP Greenville - ROA Roanoke
GSPROA
Greenville
Tue 11/17
10:52 am-3:32 pm
1 stop4h 40m
Roanoke
Sat 11/21
6:03 pm-11:31 pm
1 stop5h 28m
$442
CharlestonRoanoke
CHS Charleston - ROA Roanoke
CHSROA
Charleston
Fri 12/18
12:40 pm-2:18 pm
2 stops25h 38m
Roanoke
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$444
CharlestonRoanoke
CHS Charleston - ROA Roanoke
CHSROA
Charleston
Mon 11/30
8:29 pm-11:38 pm
1 stop3h 09m
Roanoke
Mon 12/7
6:32 pm-10:51 pm
1 stop4h 19m
$459
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Best time to book a flight from South Carolina to Roanoke
Have a flexible travel schedule? Discover the best time to fly to Roanoke from South Carolina with our price prediction graph.
CHS-ROA
GSP-ROA
CAE-ROA
HHH-ROA
MYR-ROA
Estimated round-trip price
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Cheapflights Insights
Everything you need to know about your flight from South Carolina to Roanoke
USSC-ROA
CHS-ROA
GSP-ROA
CAE-ROA
HHH-ROA
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Roanoke. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Roanoke?
Book flights to Roanoke if you plan to visit one of these locationsSalem
Blacksburg
Christiansburg
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South Carolina and Roanoke flights
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South Carolina to Roanoke flights
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Top airline flying from South Carolina to Roanoke
Discover the top airline that operate flights from South Carolina to Roanoke. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$278 | Average$278 | FlexibilityNo cancel fee | On-timeN/A |