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South Carolina

$186+ Cheap flights from Roanoke (ROA) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/7. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — CHS
Mai 29 — Jun 51
Fr 5/29
Fr 6/5
1 adult, Economy
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Cheap flight deals from Roanoke to South Carolina

Cheapest flights from Roanoke to South Carolina
Explore the most affordable flight options available from Roanoke to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.

This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 5/267:35 pm
ROA
-
CHS
1 stop4h 24m
Delta
Mi 6/35:15 am
CHS
-
ROA
1 stop5h 15m
Delta
Deal found 4/25$261
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 5/266:00 am
ROA
-
CHS
1 stop3h 38m
Delta
Mo 6/17:59 pm
CHS
-
ROA
1 stop4h 35m
Delta
Deal found 4/25$285
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 10/16:00 am
ROA
-
CHS
1 stop3h 43m
Delta
Mo 10/57:59 pm
CHS
-
ROA
1 stop3h 51m
Delta
Deal found 4/27$314
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 5/207:30 pm
ROA
-
MYR
1 stop4h 28m
Delta
Mi 5/277:55 pm
MYR
-
ROA
1 stop4h 39m
Delta
Deal found 4/24$315
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 6/224:08 pm
ROA
-
CLT
1 stop19h 26m
Multiple Airlines
Do 6/259:33 pm
CLT
-
ROA
1 stop17h 40m
Multiple Airlines
Deal found 4/27$317
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 5/126:00 am
ROA
-
CHS
1 stop6h 10m
Delta
Sa 5/166:15 am
CHS
-
ROA
1 stop4h 15m
Delta
Deal found 4/27$319
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 5/96:00 am
ROA
-
MYR
1 stop6h 40m
Delta
Mo 6/17:55 pm
MYR
-
ROA
1 stop4h 39m
Delta
Deal found 4/25$320
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 5/127:30 pm
ROA
-
MYR
1 stop4h 28m
Delta
Sa 5/166:00 am
MYR
-
ROA
1 stop4h 30m
Delta
Deal found 4/27$325
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 5/1212:58 pm
ROA
-
MYR
2 stops8h 58m
American Airlines
Sa 5/165:00 am
MYR
-
ROA
1 stop5h 38m
American Airlines
Deal found 4/27$330
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 8/296:15 am
ROA
-
CHS
1 stop3h 47m
United Airlines
Di 9/12:51 pm
CHS
-
ROA
1 stop4h 16m
United Airlines
Deal found 4/27$331
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/87:30 pm
ROA
-
MYR
1 stop4h 28m
Delta
Sa 5/166:00 am
MYR
-
ROA
1 stop4h 30m
Delta
Deal found 4/28$336
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/85:00 am
ROA
-
MYR
1 stop3h 24m
American Airlines
Sa 5/166:04 am
MYR
-
ROA
2 stops6h 29m
American Airlines
Deal found 4/28$341

Find flight deals from Roanoke to South Carolina

Keep the following information in mind while searching for Roanoke to South Carolina flight deals. Data was last updated April 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$261
(Delta)

One-way from

$186
(Kiwi.com)

Popular in

August

Cheapest in

January
Provider with most accurate pricing for Roanoke-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Roanoke-Myrtle Beach Intl flights.
Search Deals
From Roanoke to South Carolina
Search Deals
One-way flight from Roanoke to South Carolina
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($109 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Roanoke to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Di 5/26

6:00 am-9:38 am

1 stop3h 38m

Charleston

Mo 6/1

7:59 pm-12:34 am

1 stop4h 35m

$285

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Do 10/1

6:00 am-9:43 am

1 stop3h 43m

Charleston

Mo 10/5

7:59 pm-11:50 pm

1 stop3h 51m

$314

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Mi 5/20

7:30 pm-11:58 pm

1 stop4h 28m

Myrtle Beach Intl

Mi 5/27

7:55 pm-12:34 am

1 stop4h 39m

$315

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Di 5/12

7:30 pm-11:58 pm

1 stop4h 28m

Myrtle Beach Intl

Sa 5/16

6:00 am-10:30 am

1 stop4h 30m

$325

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Sa 8/29

6:15 am-10:02 am

1 stop3h 47m

Charleston

Di 9/1

8:55 am-5:06 pm

1 stop8h 11m

$331

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Fr 5/8

5:00 am-8:24 am

1 stop3h 24m

Myrtle Beach Intl

Sa 5/16

6:04 am-12:33 pm

2 stops6h 29m

$341

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Sa 8/1

2:32 pm-6:56 pm

1 stop4h 24m

Myrtle Beach Intl

Mi 8/5

5:15 pm-9:10 pm

1 stop3h 55m

$346
Quickest round-trip

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Sa 8/29

6:15 am-9:42 am

1 stop3h 27m

Myrtle Beach Intl

Di 9/1

10:28 am-2:18 pm

1 stop3h 50m

$349

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Mi 5/13

7:30 pm-11:58 pm

1 stop4h 28m

Myrtle Beach Intl

So 5/17

7:55 pm-12:34 am

1 stop4h 39m

$382

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Sa 9/12

6:47 am-1:55 pm

1 stop7h 08m

Charleston

Sa 9/19

10:00 am-2:18 pm

1 stop4h 18m

$437

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/25

Showing 1-10 of 36 resultsSorted by cheapest first
1
2
3
4

Best time to book a flight from Roanoke to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to South Carolina

What is the cheapest month to book a flight from Roanoke to South Carolina?

Currently, January is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $144). Flying from Roanoke to South Carolina in December is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Roanoke to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 29, 2026.
Read through reviews of airlines operating flights from Roanoke to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,678 reviews

Food

6.4

Boarding

7.5

Overall

7.1

Entertainment

6.9

Comfort

7.2

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!
American Airlines
7.1
Good
11,678 reviews
American Airlines
7.1
Good
11,678 reviews

Food

6.4

Boarding

7.5

Overall

7.1

Entertainment

6.9

Comfort

7.2

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!

Related info for your journey

Find useful and relevant information for your journey from Roanoke to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to South Carolina?

    If you book a flight to South Carolina from Roanoke, you will be flying from Roanoke, which is the city’s only airport. Roanoke (ROA) is located 4.2 mi from the center of Roanoke.

  • How long is the flight from Roanoke to South Carolina?

    Delta, American Airlines, and United Airlines can get you from Roanoke to South Carolina in just under 3h 24m. Your travel time can differ by up to 1h. The distance between Roanoke and South Carolina is about 258 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to South Carolina?

    When deciding which route to take from Roanoke to South Carolina consider Roanoke - Charlotte Douglas, Roanoke - Charleston or Roanoke - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Roanoke to South Carolina that include hotel bookings?

    Yes. In addition to deals on Roanoke to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to South Carolina.

  • Can I find deals for business class flights from Roanoke to South Carolina?

    Yes. Cheapflights offers flight deals from Roanoke to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $144). Flying from Roanoke to South Carolina in December is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top airline flying from Roanoke to South Carolina

Discover the top airline that operate flights from Roanoke to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$474FlexibilityNo cancel feeOn-time71%

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