$244+ Cheap flights from Roanoke (ROA) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — CHS
Oct 25 — Nov 11
Round-trip
1 adult, Economy
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Find cheap flights from Roanoke to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Roanoke to South CarolinaExplore the most affordable flight options available from Roanoke to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2026.
Explore the most affordable flight options available from Roanoke to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 25, 2026.
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:15 am -
1 stop3h 47m
Sat 10/247:51 pm -
1 stop3h 53m
Deal found 9/21![United Airlines logo]()
$305
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:03 pm -
1 stop5h 11m
Sun 11/15:05 am -
1 stop3h 21m
Deal found 9/20![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:35 am -
1 stop4h 35m
Wed 10/147:53 pm -
1 stop3h 51m
Deal found 9/20![United Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:32 pm -
1 stop5h 51m
Tue 10/135:59 pm -
1 stop6h 28m
Deal found 9/24![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:00 pm -
1 stop3h 44m
Sat 10/108:08 pm -
1 stop3h 36m
Deal found 9/22![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:57 pm -
1 stop4h 59m
Mon 10/58:08 pm -
1 stop3h 36m
Deal found 9/20![American Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
1 stop3h 30m
Sun 10/115:59 pm -
1 stop6h 28m
Deal found 9/22![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:26 am -
1 stop3h 54m
Tue 9/297:35 pm -
1 stop4h 09m
Deal found 9/22![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:05 pm -
1 stop4h 10m
Tue 10/67:53 pm -
1 stop3h 51m
Deal found 9/22![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
1 stop4h 07m
Wed 10/2810:52 am -
1 stop4h 00m
Deal found 9/20![Delta logo]()
$377
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:27 pm -
1 stop3h 29m
Tue 10/68:10 am -
1 stop5h 17m
Deal found 9/24![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:57 pm -
1 stop4h 59m
Sat 9/267:41 pm -
1 stop3h 07m
Deal found 9/20![American Airlines logo]()
$386
Best flights from Roanoke to South CarolinaDiscover carefully curated flight deals from Roanoke to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 25, 2026.
Discover carefully curated flight deals from Roanoke to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 25, 2026.
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:32 pm -
1 stop5h 51m
Tue 10/135:59 pm -
1 stop6h 28m
Deal found 9/24![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:05 pm -
1 stop4h 10m
Tue 10/137:53 pm -
1 stop3h 51m
Deal found 9/24![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:01 am -
1 stop3h 14m
Sun 11/88:35 pm -
1 stop3h 10m
Deal found 9/21![American Airlines logo]()
$553
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/183:52 pm -
1 stop22h 53m
Thu 10/222:43 pm -
1 stop24h 15m
Deal found 9/21![Allegiant Air logo]()
$593
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
1 stop3h 30m
Sun 10/115:59 pm -
1 stop6h 28m
Deal found 9/22![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:05 pm -
1 stop4h 10m
Tue 10/67:53 pm -
1 stop3h 51m
Deal found 9/22![United Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop4h 07m
Tue 10/272:16 pm -
1 stop3h 42m
Deal found 9/20![Delta logo]()
$377
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:05 pm -
1 stop4h 10m
Sun 10/186:00 am -
1 stop3h 48m
Deal found 9/20![United Airlines logo]()
$413
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
1 stop4h 07m
Thu 10/296:58 pm -
1 stop5h 29m
Deal found 9/20![Delta logo]()
$387
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:05 pm -
1 stop4h 10m
Sun 10/116:00 am -
1 stop3h 48m
Deal found 9/24![United Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:00 am -
1 stop4h 07m
Sat 11/146:00 am -
1 stop4h 37m
Deal found 9/23![Delta logo]()
$397
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:10 pm -
1 stop3h 52m
Tue 10/137:29 pm -
1 stop3h 24m
Deal found 9/24![American Airlines logo]()
$570
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/126:00 am -
1 stop3h 25m
Sun 2/145:40 am -
1 stop4h 54m
Deal found 9/21![Delta logo]()
$397
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1210:35 am -
1 stop4h 32m
Tue 12/152:57 pm -
1 stop4h 15m
Deal found 9/22![United Airlines logo]()
$470
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/244:14 pm -
1 stop5h 37m
Mon 11/304:59 pm -
1 stop4h 43m
Deal found 9/25![American Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:00 am -
2 stops8h 21m
Mon 12/712:25 pm -
1 stop3h 09m
Deal found 9/25![American Airlines logo]()
$627
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:55 pm -
1 stop4h 52m
Sat 1/97:00 am -
1 stop3h 34m
Deal found 9/21![Delta logo]()
$477
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop4h 07m
Tue 10/2710:52 am -
2 stops11h 57m
Deal found 9/20![Delta logo]()
$486
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:05 pm -
2 stops20h 12m
Sat 10/247:51 pm -
1 stop3h 53m
Deal found 9/21![United Airlines logo]()
$589
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:05 pm -
1 stop4h 10m
Sun 10/187:53 pm -
1 stop3h 51m
Deal found 9/24![United Airlines logo]()
$594
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:21 am -
1 stop5h 05m
Sun 10/252:56 pm -
1 stop5h 41m
Deal found 9/24![American Airlines logo]()
$817
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:00 am -
1 stop4h 07m
Thu 10/296:58 pm -
1 stop5h 29m
Deal found 9/20![Delta logo]()
$565
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:05 pm -
1 stop13h 42m
Sat 10/105:38 pm -
1 stop5h 21m
Deal found 9/21![United Airlines logo]()
$623
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop4h 07m
Fri 10/236:58 pm -
1 stop5h 29m
Deal found 9/20![Delta logo]()
$565
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:15 am -
1 stop3h 29m
Fri 10/166:55 pm -
2 stops28h 49m
Deal found 9/24![United Airlines logo]()
$653
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/125:38 pm -
2 stops20h 32m
Sun 2/146:30 am -
1 stop7h 03m
Deal found 9/21![United Airlines logo]()
$672
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:38 pm -
1 stop4h 13m
Sun 10/255:40 am -
1 stop4h 52m
Deal found 9/22![Delta logo]()
$623
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/188:05 pm -
2 stops24h 46m
Sat 1/95:31 pm -
1 stop7h 01m
Deal found 9/21![United Airlines logo]()
$673
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
1 stop4h 07m
Fri 10/166:59 pm -
1 stop5h 28m
Deal found 9/24![Delta logo]()
$665
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:15 am -
1 stop3h 32m
Sun 10/116:15 am -
2 stops27h 33m
Deal found 9/22![United Airlines logo]()
$678
Last-minute flights from Roanoke to South CarolinaDiscover last-minute flight deals from Roanoke to South Carolina. Data last updated September 25, 2026 and is based on user searches.
Discover last-minute flight deals from Roanoke to South Carolina. Data last updated September 25, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/241:57 pm -
1 stop4h 59m
Sat 9/267:41 pm -
1 stop3h 07m
Deal found 9/20![American Airlines logo]()
$386
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:57 pm -
1 stop4h 59m
Mon 10/58:08 pm -
1 stop3h 36m
Deal found 9/20![American Airlines logo]()
$356
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:05 pm -
1 stop4h 10m
Tue 10/67:53 pm -
1 stop3h 51m
Deal found 9/22![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:27 pm -
1 stop3h 29m
Tue 10/68:10 am -
1 stop5h 17m
Deal found 9/24![American Airlines logo]()
$383
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:00 pm -
1 stop3h 44m
Sat 10/108:08 pm -
1 stop3h 36m
Deal found 9/22![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:35 am -
1 stop4h 35m
Wed 10/147:53 pm -
1 stop3h 51m
Deal found 9/20![United Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
1 stop3h 30m
Sun 10/115:59 pm -
1 stop6h 28m
Deal found 9/22![Delta logo]()
$359
This Delta deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:32 pm -
1 stop5h 51m
Tue 10/135:59 pm -
1 stop6h 28m
Deal found 9/24![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:15 am -
1 stop3h 47m
Sat 10/247:51 pm -
1 stop3h 53m
Deal found 9/21![United Airlines logo]()
$305
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
1 stop4h 07m
Wed 10/2810:52 am -
1 stop4h 00m
Deal found 9/20![Delta logo]()
$377
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:00 am -
1 stop4h 07m
Wed 10/286:00 am -
1 stop4h 32m
Deal found 9/20![Delta logo]()
$387
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:03 pm -
1 stop5h 11m
Sun 11/15:05 am -
1 stop3h 21m
Deal found 9/20![American Airlines logo]()
$319
One-way flights from Roanoke to South CarolinaSearch for one-way flight options from Roanoke to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 25, 2026.
Search for one-way flight options from Roanoke to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 25, 2026.
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:35 pm -
1 stop3h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Delta logo]()
$244
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:15 am -
1 stop3h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![United Airlines logo]()
$244
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/244:12 pm -
1 stop5h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$245
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:07 am -
1 stop3h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:03 pm -
1 stop5h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![American Airlines logo]()
$384
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:40 am -
1 stop3h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$410
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:48 pm -
3 stops44h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$437
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/84:12 pm -
3 stops41h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$452
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:02 pm -
1 stop4h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$473
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:05 pm -
2 stops15h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$475
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/84:12 pm -
2 stops26h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Allegiant Air logo]()
$485
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:26 am -
3 stops23h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$533
Find flight deals from Roanoke to South Carolina
Keep the following information in mind while searching for Roanoke to South Carolina flight deals. Data was last updated September 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $305 (United Airlines) |
One-way from | $244 (Delta) |
Popular in | April |
Cheapest in | January |
Average price | $313 |
Cheapflights Fare Finder
Customize your flight search to find flights from Roanoke to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 25, 2026.
Use the filters below to find and compare flights from Roanoke to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
RoanokeColumbia
ROA Roanoke - CAE Columbia Metropolitan
ROACAE
Roanoke
Sun 10/25
6:00 am-10:43 am
1 stop4h 43m
Columbia Metropolitan
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$244
Quickest round-trip
RoanokeMyrtle Beach
ROA Roanoke - MYR Myrtle Beach Intl
ROAMYR
Roanoke
Fri 10/23
6:15 am-9:44 am
1 stop3h 29m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$244
RoanokeColumbia
ROA Roanoke - CAE Columbia Metropolitan
ROACAE
Roanoke
Sat 10/24
4:35 pm-8:10 pm
1 stop3h 35m
Columbia Metropolitan
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$244
RoanokeColumbia
ROA Roanoke - CAE Columbia Metropolitan
ROACAE
Roanoke
Fri 10/9
3:32 pm-9:23 pm
1 stop5h 51m
Columbia Metropolitan
Tue 10/13
5:59 pm-12:27 am
1 stop6h 28m
$339
RoanokeCharleston
ROA Roanoke - CHS Charleston
ROACHS
Roanoke
Fri 10/9
8:05 pm-12:15 am
1 stop4h 10m
Charleston
Tue 10/13
7:53 pm-11:44 pm
1 stop3h 51m
$349
RoanokeColumbia
ROA Roanoke - CAE Columbia Metropolitan
ROACAE
Roanoke
Wed 10/7
6:00 am-9:30 am
1 stop3h 30m
Columbia Metropolitan
Sun 10/11
5:59 pm-12:27 am
1 stop6h 28m
$359
RoanokeCharleston
ROA Roanoke - CHS Charleston
ROACHS
Roanoke
Thu 10/1
8:05 pm-12:15 am
1 stop4h 10m
Charleston
Tue 10/6
7:53 pm-11:44 pm
1 stop3h 51m
$369
RoanokeMyrtle Beach
ROA Roanoke - MYR Myrtle Beach Intl
ROAMYR
Roanoke
Wed 10/21
6:00 am-10:07 am
1 stop4h 07m
Myrtle Beach Intl
Tue 10/27
2:16 pm-5:58 pm
1 stop3h 42m
$377
RoanokeCharleston
ROA Roanoke - CHS Charleston
ROACHS
Roanoke
Mon 10/5
1:03 pm-6:14 pm
1 stop5h 11m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$384
RoanokeCharleston
ROA Roanoke - CHS Charleston
ROACHS
Roanoke
Sun 10/4
6:00 am-10:08 am
1 stop4h 08m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$384
Showing 1-10 of 43 resultsSorted by cheapest first
Best time to book a flight from Roanoke to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Roanoke with our price prediction graph.
ROA-CHS
ROA-CAE
ROA-MYR
ROA-GSP
ROA-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Roanoke to South Carolina
ROA-USSC
ROA-CHS
ROA-CAE
ROA-MYR
ROA-GSP
What is the cheapest month to book a flight from Roanoke to South Carolina?
Currently, January is the cheapest month in which you can book a flight from Roanoke to South Carolina (average of $228). Flying from Roanoke to South Carolina in April is currently the most expensive (average of $686). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Roanoke to South Carolina?
Airfare is typical for this route at the moment.
Roanoke to South Carolina flights typically cost between $298 and $496 in October.The cheapest round-trip price found within the last 5 days was $305 on United Airlines (Oct 19-Oct 24).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 25, 2026.
Read through reviews of airlines operating flights from Roanoke to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.4
Food
6.4
Overall
7.0
Comfort
7.2
Crew
7.9
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Boarding
7.4
Food
6.4
Overall
7.0
Comfort
7.2
Crew
7.9
Entertainment
6.8
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Roanoke to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Roanoke to South Carolina
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Complete your trip
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Roanoke and South Carolina flights
Browse other Roanoke and South Carolina flight options. Last updated on September 25, 2026.
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Roanoke to South Carolina flights
Consider these flights traveling from Roanoke to South Carolina.
Top airline flying from Roanoke to South Carolina
Discover the top airline that operate flights from Roanoke to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$218 | Average$474 | FlexibilityNo cancel fee | On-time71% |