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Panama City

$141+ Cheap flights from Mesa, AZ to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — PTY
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Panama City Tocumen Intl are usually found in April or May, booked 18 days in advance, depart on a Tuesday or Wednesday and return on a Sunday

Find flight deals from Mesa to Panama City

Cheapest flights from Mesa to Panama City
Explore the most affordable flight options available from Mesa to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1911:38 amPHX - PTY
2 stops30h 49mMultiple Airlines
Wed 12/31:45 pmPTY - PHX
1 stop25h 45mMultiple Airlines
Deal found 10/23$527
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:25 amPHX - PTY
1 stop19h 55mMultiple Airlines
Thu 12/47:50 pmPTY - PHX
2 stops30h 50mMultiple Airlines
Deal found 10/21$563
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/712:50 pmPHX - PTY
1 stop14h 30mMultiple Airlines
Sat 12/132:55 amPTY - PHX
2 stops23h 10mMultiple Airlines
Deal found 10/23$569
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:25 amPHX - PTY
1 stop19h 55mMultiple Airlines
Sun 11/91:15 pmPTY - PHX
1 stop11h 54mMultiple Airlines
Deal found 10/23$572
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:51 pmPHX - PTY
1 stop31h 29mMultiple Airlines
Sat 12/133:50 pmPTY - PHX
2 stops33h 39mMultiple Airlines
Deal found 10/22$594
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/109:40 amPHX - PTY
1 stop7h 58mUnited Airlines
Sun 12/1411:35 amPTY - PHX
1 stop11h 01mUnited Airlines
Deal found 10/21$616
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:55 pmPHX - PTY
1 stop11h 25mMultiple Airlines
Thu 12/112:55 amPTY - PHX
2 stops35h 47mMultiple Airlines
Deal found 10/21$619
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/412:30 amPHX - PTY
2 stops13h 12mAmerican Airlines
Fri 12/122:50 pmPTY - PHX
2 stops19h 00mAmerican Airlines
Deal found 10/21$620
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/912:30 amPHX - PTY
2 stops13h 12mAmerican Airlines
Sun 12/144:43 pmPTY - PHX
2 stops17h 01mAmerican Airlines
Deal found 10/21$625

Cheap flight deals from Mesa to Panama City

Keep the following information in mind while searching for Mesa to Panama City flight deals. Data was last updated October 23, 2025.

Round-trip from

$527
(Kiwi.com)

One-way from

$141
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$674
From Mesa to Panama City Tocumen Intl
Search Deals
One-way flight from Mesa to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($54 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from Mesa to Panama City that are best for you.

Fly from

Mesa

Fly to

Panama City

Route

Depart

Return

Price

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Fri 11/7

7:25 am-5:20 am

1 stop19h 55m

Panama City Tocumen Intl

Sun 11/9

1:15 pm-11:09 pm

1 stop11h 54m

$572

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Wed 11/26

7:25 am-5:20 am

1 stop19h 55m

Panama City Tocumen Intl

Sun 11/30

1:15 pm-9:42 am

1 stop22h 27m

$572

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Tue 1/13

5:34 pm-2:45 pm

2 stops19h 11m

Panama City Tocumen Intl

Tue 1/20

4:41 pm-10:54 am

2 stops20h 13m

$600

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Tue 2/3

5:34 pm-2:45 pm

2 stops19h 11m

Panama City Tocumen Intl

Tue 2/17

11:35 am-10:50 pm

2 stops13h 15m

$600

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Thu 4/2

6:00 am-6:37 pm

2 stops10h 37m

Panama City Tocumen Intl

Wed 4/8

3:20 pm-12:36 pm

3 stops23h 16m

$600

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Sat 2/14

7:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Tue 2/24

8:55 am-6:59 pm

1 stop12h 04m

$609

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Wed 12/10

9:40 am-7:38 pm

1 stop7h 58m

Panama City Tocumen Intl

Sun 12/14

11:35 am-8:36 pm

1 stop11h 01m

$616

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Mon 1/12

5:10 pm-5:07 pm

2 stops21h 57m

Panama City Tocumen Intl

Fri 1/16

4:41 pm-1:54 pm

3 stops23h 13m

$620

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Wed 11/26

10:55 pm-5:08 pm

1 stop16h 13m

$141

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Sun 11/16

7:37 am-6:10 am

2 stops44h 33m

$218

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/23

Showing 1-10 of 16 results
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Best time to book a flight from Mesa to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Panama City

How far ahead should I book a flight from Mesa to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Panama City. Price data was last updated on October 17, 2025.

The price you pay for your flight from Mesa to Panama City may vary depending on when you book. For the best chance of a lower fare, look to book 10 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Panama City?

Currently, May is the cheapest month in which you can book a flight from Mesa to Panama City (average of $512). Flying from Mesa to Panama City in June is currently the most expensive (average of $593). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to PTY?

Find hourly flight availability from Mesa to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 27% on flights from Mesa to Panama City by exploring options for tickets at noon.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 23, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Mesa to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,982 reviews

Crew

8.5

Overall

7.9

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,982 reviews
Delta
7.9
Good
7,982 reviews

Crew

8.5

Overall

7.9

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,995 reviews
Delta
7.9
Good
7,982 reviews

Crew

8.5

Overall

7.9

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,982 reviews

Crew

8.5

Overall

7.9

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Mesa?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Mesa to Panama City. 3 airlines have flights to Tocumen Intl from Mesa on a regular basis. Booking flights from Mesa to Panama City Tocumen Intl should not be difficult; the airport handles an average of 0 inbound flights from Mesa per day.

  • How long is the flight from Mesa to Panama City?

    United Airlines can get you from Mesa to Panama City in just under 19h 11m. Your travel time can differ by up to . Mesa and Panama City are separated by a distance of 2668 mi.

  • Can I find deals for flights from Mesa to Panama City that include hotel bookings?

    Yes. In addition to deals on Mesa to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Panama City.

  • Can I find deals for business class flights from Mesa to Panama City?

    Yes. Cheapflights offers flight deals from Mesa to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Panama City?

    Currently, May is the cheapest month in which you can book a flight from Mesa to Panama City (average of $512). Flying from Mesa to Panama City in June is currently the most expensive (average of $593). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Mesa to Panama City

Discover the top 3 airlines that operate flights from Mesa to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$549Average$714FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$549Average$649FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$599Average$724FlexibilityNo cancel feeOn-time71%

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