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Panama City

$285+ Cheap flights from Mesa, AZ to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — PTY
Aug 23 — Aug 301
Sat 8/23
Sat 8/30
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Panama City Tocumen Intl are usually found in April or May, booked 18 days in advance, depart on a Tuesday or Wednesday and return on a Sunday

Cheap flight deals from Mesa to Panama City

Keep the following information in mind while searching for Mesa to Panama City flight deals. Data was last updated August 18, 2025.

Round-trip from

$513
(Kiwi.com)

One-way from

$285
(United Airlines)

Popular in

December

Cheapest in

April

Average price

$672
From Mesa to Panama City Tocumen Intl
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One-way flight from Mesa to Panama City Tocumen Intl
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Highest demand for flights based on searches. 15% potential increase in price ($125 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($37 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Mesa to Panama City

Cheapest flights from Mesa to Panama City
Explore the most affordable flight options available from Mesa to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/145:27 pmPHX - PTY
1 stop9h 58mMultiple Airlines
Sat 9/203:20 amPTY - PHX
2 stops33h 36mMultiple Airlines
Deal found 8/15$513
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/174:30 pmPHX - PTY
1 stop10h 55mMultiple Airlines
Mon 9/221:15 pmPTY - PHX
1 stop11h 11mMultiple Airlines
Deal found 8/17$555
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/174:30 pmPHX - PTY
1 stop10h 55mMultiple Airlines
Sun 9/211:15 pmPTY - PHX
1 stop9h 45mMultiple Airlines
Deal found 8/17$561
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/213:11 pmPHX - PTY
1 stop19h 45mDelta
Tue 10/282:21 pmPTY - PHX
1 stop10h 39mDelta
Deal found 8/16$595
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2012:18 amPHX - PTY
2 stops11h 45mAmerican Airlines
Tue 10/283:15 pmPTY - PHX
2 stops19h 52mAmerican Airlines
Deal found 8/17$600
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/711:03 amPHX - PTY
1 stop29h 46mUnited Airlines
Thu 12/1811:35 amPTY - PHX
1 stop12h 21mUnited Airlines
Deal found 8/17$603
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1611:55 pmPHX - PTY
1 stop11h 57mDelta
Sat 11/223:17 pmPTY - PHX
1 stop10h 42mDelta
Deal found 8/18$615
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/168:50 pmPHX - PTY
2 stops20h 48mUnited Airlines
Sat 11/228:55 amPTY - PHX
1 stop9h 36mUnited Airlines
Deal found 8/18$620

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mesa to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from Mesa to Panama City that are best for you.

Fly from

Mesa

Fly to

Panama City

Route

Depart

Return

Price

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Sun 9/14

5:27 pm-5:25 am

1 stop9h 58m

Panama City Tocumen Intl

Sat 9/20

3:20 am-10:56 am

2 stops33h 36m

$513

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Wed 9/17

4:30 pm-5:25 am

1 stop10h 55m

Panama City Tocumen Intl

Mon 9/22

1:15 pm-10:26 pm

1 stop11h 11m

$555

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Wed 9/17

4:30 pm-5:25 am

1 stop10h 55m

Panama City Tocumen Intl

Sun 9/21

1:15 pm-9:00 pm

1 stop9h 45m

$561

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Tue 10/21

3:11 pm-12:56 pm

1 stop19h 45m

Panama City Tocumen Intl

Tue 10/28

2:21 pm-11:00 pm

1 stop10h 39m

$595

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Tue 10/21

9:00 am-6:37 pm

1 stop7h 37m

Panama City Tocumen Intl

Tue 10/28

7:55 am-8:21 pm

2 stops14h 26m

$595

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Wed 10/15

9:00 am-6:37 pm

1 stop7h 37m

Panama City Tocumen Intl

Mon 10/20

10:00 am-8:51 pm

1 stop12h 51m

$595

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Mon 1/5

7:15 am-7:38 pm

1 stop10h 23m

Panama City Tocumen Intl

Mon 1/19

8:55 am-9:56 pm

1 stop15h 01m

$595

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Thu 11/27

6:25 am-6:49 pm

1 stop10h 24m

$285

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Mon 1/26

12:45 am-3:35 pm

2 stops12h 50m

$285

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Tue 1/27

11:55 pm-2:02 pm

1 stop12h 07m

$285

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/16

Showing 1-10 of 17 results
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Best time to book a flight from Mesa to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Panama City

How far ahead should I book a flight from Mesa to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Panama City. Price data was last updated on August 8, 2025.

The price you pay for your flight from Mesa to Panama City may vary depending on when you book. For the best chance of a lower fare, look to book 10 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Panama City?

Currently, October is the cheapest month in which you can book a flight from Mesa to Panama City (average of $478). Flying from Mesa to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to PTY?

Find hourly flight availability from Mesa to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 18, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mesa to Panama City as you normally would.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated August 18, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Mesa to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,925 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Mesa to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Mesa?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Mesa to Panama City. 3 airlines have flights to Tocumen Intl from Mesa on a regular basis. Booking flights from Mesa to Panama City Tocumen Intl should not be difficult; the airport handles an average of 0 inbound flights from Mesa per day.

  • How long is the flight from Mesa to Panama City?

    Delta can get you from Mesa to Panama City in just under 19h 45m. Your travel time can differ by up to . Mesa and Panama City are separated by a distance of 2668 mi.

  • What are the cheapest airlines to fly from Mesa to Panama City one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $285. Users have also found prices from $285 and $285 on American Airlines and Delta, respectively.

  • Can I find deals for flights from Mesa to Panama City that include hotel bookings?

    Yes. In addition to deals on Mesa to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Panama City.

  • Can I find deals for business class flights from Mesa to Panama City?

    Yes. Cheapflights offers flight deals from Mesa to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Mesa to Panama City (average of $478). Flying from Mesa to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Mesa to Panama City

Discover the top 3 airlines that operate flights from Mesa to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$549Average$653FlexibilityNo cancel feeOn-time69%
DeltaCheapest$567Average$743FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$595Average$719FlexibilityNo cancel feeOn-time71%

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