HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$262+ Cheap flights from Mesa, AZ to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — PTY
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mesa to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Mesa to Panama City Tocumen Intl are usually found in April or July, booked 10 days in advance, depart on a Tuesday or Wednesday and return on a Sunday

Cheap flight deals from Mesa to Panama City

Keep the following information in mind while searching for Mesa to Panama City flight deals. Data was last updated May 1, 2025.

Round-trip from

$558
(Kiwi.com)

One-way from

$262
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$629
From Mesa to Panama City Tocumen Intl
Search Deals
One-way flight from Mesa to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($135 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($39 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals

Find flight deals from Mesa to Panama City

Cheapest flights from Mesa to Panama City
Explore the most affordable flight options available from Mesa to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/126:05 amPHX - PTY
1 stop12h 34mMultiple Airlines
Thu 6/1910:05 pmPTY - PHX
2 stops39h 11mMultiple Airlines
Deal found 4/29$558
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2111:55 pmPHX - PTY
1 stop10h 52mDelta
Tue 10/282:12 pmPTY - PHX
1 stop10h 47mDelta
Deal found 4/30$575
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/307:37 pmPHX - PTY
3 stops18h 35mUnited Airlines
Mon 7/73:15 pmPTY - PHX
1 stop21h 33mUnited Airlines
Deal found 4/30$580
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/154:26 pmPHX - PTY
1 stop18h 59mAmerican Airlines
Thu 1/82:45 pmPTY - PHX
1 stop24h 33mAmerican Airlines
Deal found 4/30$632
This Orbitz deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/186:00 amPHX - PTY
3 stops26h 25mAvianca
Wed 5/213:40 pmPTY - PHX
2 stops20h 11mAvianca
Deal found 4/30$1,170
This Iberia deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/169:45 amPHX - PTY
2 stops29h 05mIberia
Mon 1/56:20 pmPTY - PHX
2 stops29h 49mIberia
Deal found 4/30$3,531

Cheapflights Fare Finder

Customize your flight search to find flights from Mesa to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Mesa to Panama City that are best for you.

Fly from

Mesa

Fly to

Panama City

Route

Depart

Return

Price

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Thu 6/12

6:05 am-8:39 pm

1 stop12h 34m

Panama City Tocumen Intl

Thu 6/19

10:05 pm-11:16 am

2 stops39h 11m

$558

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Tue 10/21

11:55 pm-12:47 pm

1 stop10h 52m

Panama City Tocumen Intl

Tue 10/28

2:12 pm-10:59 pm

1 stop10h 47m

$575

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Mon 6/30

4:28 pm-2:14 pm

2 stops19h 46m

Panama City Tocumen Intl

Mon 7/7

7:55 am-7:22 pm

1 stop13h 27m

$580

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Sun 6/29

12:30 am-2:25 pm

2 stops11h 55m

Panama City Tocumen Intl

Mon 7/7

3:10 pm-9:20 am

1 stop20h 10m

$636

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Sun 5/18

6:00 am-10:25 am

3 stops26h 25m

Panama City Tocumen Intl

Wed 5/21

3:40 pm-9:51 am

2 stops20h 11m

$1,170

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Sun 5/18

9:19 am-4:39 pm

3 stops29h 20m

$262

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Mon 7/14

7:37 pm-4:12 pm

3 stops18h 35m

$275

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Tue 5/13

11:25 pm-12:48 pm

1 stop11h 23m

$325

PhoenixPanama City

PHX - PTY

PHXPTY

Phoenix Sky Harbor Intl

Sat 7/12

12:38 am-2:15 pm

2 stops11h 37m

$340

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Best time to book a flight from Mesa to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Panama City

How far ahead should I book a flight from Mesa to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Panama City. Price data was last updated on April 25, 2025.

The price you pay for your flight from Mesa to Panama City may vary depending on when you book. For the best chance of a lower fare, look to book 10 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Panama City?

Currently, October is the cheapest month in which you can book a flight from Mesa to Panama City (average of $478). Flying from Mesa to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to PTY?

Find hourly flight availability from Mesa to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mesa to Panama City as you normally would.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated May 1, 2025.
See what other customers who have flown with Delta, United Airlines and American Airlines from Mesa to Panama City have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,317 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Mesa to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Mesa?

    Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Mesa to Panama City. 3 airlines have flights to Tocumen Intl from Mesa on a regular basis. Booking flights from Mesa to Panama City Tocumen Intl should not be difficult; the airport handles an average of 0 inbound flights from Mesa per day.

  • Can I find deals for flights from Mesa to Panama City that include hotel bookings?

    Yes. In addition to deals on Mesa to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Panama City.

  • Can I find deals for business class flights from Mesa to Panama City?

    Yes. Cheapflights offers flight deals from Mesa to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Mesa to Panama City (average of $478). Flying from Mesa to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mesa to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Sky Harbor Intl to Panama City flights
Las Vegas to Panama City flights
Tucson to Panama City flights
Yuma to Panama City flights
Sky Harbor Intl to David flights
Tucson to David flights

Top 3 airlines flying from Mesa to Panama City

Discover the top 3 airlines that operate flights from Mesa to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$549Average$714FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$549Average$653FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$554Average$753FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.