To save up to 9% on this flight, we recommend booking at least 58 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Mesa to Panama City from $567 1-2 weeks out and tickets from $602 for flights departing within the next 72 hours.
Flights from Mesa to Panama City lean towards being more expensive in December. Prices are generally better when you fly from Mesa to Panama City in February, with the cheapest ticket starting at $357.