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Panama City

$179+ Cheap flights from Louisville (SDF) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/31. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — PTY
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Louisville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$423
(United Airlines)

One-way from

$179
(Delta)

Popular in

December

Cheapest in

May

Average price

$449
From Louisville Intl to Panama City Tocumen Intl
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One-way flight from Louisville Intl to Panama City Tocumen Intl
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Highest demand for flights based on searches. 13% potential increase in price ($80 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Louisville to Panama City

Cheapest flights from Louisville to Panama City
Explore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/219:40 amSDF - PTY
1 stop9h 57mUnited Airlines
Thu 10/2310:00 amPTY - SDF
1 stop10h 54mUnited Airlines
Deal found 9/17$423
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/167:00 amSDF - PTY
2 stops12h 38mUnited Airlines
Tue 12/304:41 pmPTY - SDF
2 stops20h 32mUnited Airlines
Deal found 9/16$428
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:15 amSDF - PTY
1 stop12h 22mUnited Airlines
Wed 10/223:30 pmPTY - SDF
1 stop29h 24mUnited Airlines
Deal found 9/15$432
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/169:30 amSDF - PTY
1 stop10h 08mUnited Airlines
Sun 12/284:41 pmPTY - SDF
2 stops17h 22mUnited Airlines
Deal found 9/16$435
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/297:20 pmSDF - PTY
2 stops24h 17mUnited Airlines
Mon 10/63:30 pmPTY - SDF
1 stop20h 40mUnited Airlines
Deal found 9/15$436
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/219:40 amSDF - PTY
1 stop9h 57mUnited Airlines
Sun 10/263:41 pmPTY - SDF
2 stops17h 18mUnited Airlines
Deal found 9/17$437
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2312:54 pmSDF - PTY
1 stop25h 02mDelta
Wed 10/292:21 pmPTY - SDF
1 stop8h 40mDelta
Deal found 9/17$439
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:00 amSDF - PTY
1 stop9h 03mAmerican Airlines
Sun 10/263:15 pmPTY - SDF
2 stops22h 47mAmerican Airlines
Deal found 9/17$442
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/277:00 amSDF - PTY
1 stop12h 37mUnited Airlines
Wed 10/19:45 amPTY - SDF
1 stop9h 42mUnited Airlines
Deal found 9/15$443
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/257:15 amSDF - PTY
1 stop7h 59mUnited Airlines
Sun 10/263:41 pmPTY - SDF
2 stops17h 18mUnited Airlines
Deal found 9/17$446

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Louisville to Panama City that are best for you.

Fly from

Louisville

Fly to

Panama City

Route

Depart

Return

Price

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 12/16

7:10 am-5:07 pm

1 stop9h 57m

Panama City Tocumen Intl

Mon 12/29

8:55 am-7:59 pm

1 stop11h 04m

$423

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 10/27

8:15 pm-12:56 pm

1 stop17h 41m

Panama City Tocumen Intl

Wed 10/29

2:21 pm-12:01 am

1 stop8h 40m

$423

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 10/22

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Tue 10/28

7:55 am-9:57 pm

1 stop13h 02m

$423

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 10/15

6:46 pm-2:03 pm

2 stops20h 17m

Panama City Tocumen Intl

Wed 10/22

3:15 pm-3:06 pm

2 stops22h 51m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 10/15

7:20 pm-6:37 pm

2 stops24h 17m

Panama City Tocumen Intl

Wed 10/22

3:30 pm-10:01 am

2 stops17h 31m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 10/21

8:45 am-6:37 pm

2 stops10h 52m

Panama City Tocumen Intl

Tue 10/28

7:55 am-9:57 pm

1 stop13h 02m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 12/16

9:30 am-5:07 pm

1 stop7h 37m

Panama City Tocumen Intl

Tue 12/30

4:41 pm-10:03 am

2 stops17h 22m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Thu 10/30

7:10 am-6:38 pm

1 stop12h 28m

Panama City Tocumen Intl

Thu 11/6

4:41 pm-9:59 am

2 stops17h 18m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 10/21

8:45 am-6:37 pm

2 stops10h 52m

Panama City Tocumen Intl

Thu 10/23

10:00 am-9:54 pm

1 stop10h 54m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Tue 12/30

6:11 pm-5:07 pm

2 stops22h 56m

$179

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 21 results
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Best time to book a flight from Louisville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Panama City

What is the cheapest month to book a flight from Louisville to Panama City?

Currently, October is the cheapest month in which you can book a flight from Louisville to Panama City (average of $478). Flying from Louisville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to PTY?

Find hourly flight availability from Louisville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

One of the essential ways to save on airfare from Louisville to Panama City is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 23% on airfare.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Louisville to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Louisville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Panama City?

    Airlines like United Airlines, Delta, and American Airlines fly from Louisville to Panama City in about 9h 57m. The time it takes to get you to your destination can typically vary by up to 10h 20m. There are 2048 mi between Louisville and Panama City. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Louisville to Panama City round-trip?

    According to our current data, American Airlines ($338), United Airlines ($351), and Delta ($382) offers the cheapest pricing from Louisville to Panama City. American Airlines is currently priced 34% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Louisville to Panama City one-way?

    The cheapest airlines for a one-way flight from Louisville to Panama City are United Airlines ($179), Delta ($179), and American Airlines ($179).

  • Can I find deals for flights from Louisville to Panama City that include hotel bookings?

    Yes. In addition to deals on Louisville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Panama City.

  • Can I find deals for business class flights from Louisville to Panama City?

    Yes. Cheapflights offers flight deals from Louisville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Louisville to Panama City (average of $478). Flying from Louisville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Louisville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisville to Panama City

Discover the top 3 airlines that operate flights from Louisville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$338Average$567FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$351Average$528FlexibilityNo cancel feeOn-time69%
DeltaCheapest$382Average$504FlexibilityNo cancel feeOn-timeN/A

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