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Panama City

$428+ Cheap flights from Louisville (SDF) to Panama City (PTY)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — PTY
Dec 20 — Dec 271
Sat 12/20
Sat 12/27
1 adult, Economy
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Find flight deals from Louisville to Panama City

Cheapest flights from Louisville to Panama City
Explore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.

This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/27:10 amSDF - PTY
1 stop7h 35mUnited Airlines
Sun 12/78:55 amPTY - SDF
1 stop13h 02mUnited Airlines
Deal found 11/20$444
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:20 pmSDF - PTY
2 stops20h 27mAmerican Airlines
Sun 12/74:43 pmPTY - SDF
2 stops20h 28mAmerican Airlines
Deal found 11/20$453
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/99:31 amSDF - PTY
1 stop10h 07mUnited Airlines
Mon 12/158:55 amPTY - SDF
1 stop10h 59mUnited Airlines
Deal found 11/20$465
This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:30 amSDF - PTY
1 stop11h 30mDelta
Sat 12/278:00 amPTY - SDF
1 stop7h 59mDelta
Deal found 11/19$789
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/213:44 pmSDF - PTY
2 stops22h 09mAmerican Airlines
Sat 12/272:53 pmPTY - SDF
2 stops17h 57mAmerican Airlines
Deal found 11/19$792
This deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:10 amSDF - PTY
1 stop12h 28mUnited Airlines
Sun 11/308:55 amPTY - SDF
1 stop10h 59mUnited Airlines
Deal found 11/19$969
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:19 pmSDF - PTY
2 stops21h 35mAmerican Airlines
Sun 1/44:55 pmPTY - SDF
2 stops20h 35mAmerican Airlines
Deal found 11/19$1,043
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:00 amSDF - PTY
1 stop13h 38mUnited Airlines
Sun 1/44:41 pmPTY - SDF
1 stop27h 18mUnited Airlines
Deal found 11/19$1,380

Cheap flight deals from Louisville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 20, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$428
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$595
Provider with most accurate pricing for Louisville Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Louisville Intl-Panama City Tocumen Intl flights.
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From Louisville Intl to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($80 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Louisville to Panama City that are best for you.

Fly from

Louisville

Fly to

Panama City

Route

Depart

Return

Price

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sun 1/18

6:12 pm-5:07 pm

2 stops22h 55m

Panama City Tocumen Intl

Thu 1/22

4:41 pm-1:28 pm

2 stops20h 47m

$428

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Fri 1/9

8:30 am-8:02 pm

1 stop11h 32m

Panama City Tocumen Intl

Thu 2/5

8:55 am-9:59 pm

1 stop13h 04m

$431

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 2/14

6:00 am-5:07 pm

1 stop11h 07m

Panama City Tocumen Intl

Thu 2/19

11:35 am-9:46 pm

1 stop10h 11m

$431

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 5/16

6:21 pm-12:15 pm

2 stops18h 54m

Panama City Tocumen Intl

Tue 6/2

1:50 pm-10:13 am

2 stops19h 23m

$435

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 5/16

8:15 pm-12:15 pm

2 stops17h 00m

Panama City Tocumen Intl

Wed 6/3

1:50 pm-9:04 am

2 stops18h 14m

$435

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 2/28

3:49 pm-1:40 pm

2 stops21h 51m

Panama City Tocumen Intl

Thu 3/5

4:04 pm-3:03 pm

2 stops22h 59m

$435

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 5/16

6:00 pm-2:14 pm

2 stops21h 14m

Panama City Tocumen Intl

Wed 6/3

10:00 am-9:30 pm

1 stop10h 30m

$435

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 2/28

5:54 pm-5:07 pm

2 stops23h 13m

Panama City Tocumen Intl

Thu 3/5

11:35 am-9:59 pm

1 stop10h 24m

$435

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 3/7

9:00 am-5:10 am

2 stops20h 10m

Panama City Tocumen Intl

Thu 3/12

3:41 pm-1:17 pm

2 stops20h 36m

$435

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Compare providers for flights from Louisville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Panama City in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Louisville-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Louisville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Panama City

What is the cheapest month to book a flight from Louisville to Panama City?

Currently, June is the cheapest month in which you can book a flight from Louisville to Panama City (average of $337). Flying from Louisville to Panama City in November is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to PTY?

Find hourly flight availability from Louisville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 20, 2025.

One of the essential ways to save on airfare from Louisville to Panama City is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 67% on airfare.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated November 20, 2025.
Read through reviews of airlines operating flights from Louisville to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,029 reviews
Delta
7.9
Good
8,002 reviews

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,002 reviews

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Panama City?

    Airlines like American Airlines and United Airlines fly from Louisville to Panama City in about 7h 52m. The time it takes to get you to your destination can typically vary by up to 1h 46m. There are 2048 mi between Louisville and Panama City. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Louisville to Panama City round-trip?

    According to our current data, United Airlines ($351), Delta ($392), and American Airlines ($410) offers the cheapest pricing from Louisville to Panama City. United Airlines is currently priced 30% below the average price you’ll pay for this route.

  • Can I find deals for flights from Louisville to Panama City that include hotel bookings?

    Yes. In addition to deals on Louisville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Panama City.

  • Can I find deals for business class flights from Louisville to Panama City?

    Yes. Cheapflights offers flight deals from Louisville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Panama City?

    Currently, June is the cheapest month in which you can book a flight from Louisville to Panama City (average of $337). Flying from Louisville to Panama City in November is currently the most expensive (average of $478). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Louisville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisville to Panama City

Discover the top 3 airlines that operate flights from Louisville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$351Average$534FlexibilityNo cancel feeOn-time69%
DeltaCheapest$392Average$499FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$410Average$562FlexibilityNo cancel feeOn-time71%

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