$286+ Cheap flights from Louisville (SDF) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — PTY
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Louisville to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Louisville to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Louisville to Panama CityExplore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:10 am -
1 stop8h 02m
Tue 12/1511:35 am -
1 stop10h 24m
Deal found 9/13![United Airlines logo]()
$607
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:16 am -
1 stop8h 46m
Tue 12/110:00 am -
1 stop9h 25m
Deal found 9/17![United Airlines logo]()
$627
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:10 am -
1 stop10h 28m
Sat 12/1210:00 am -
1 stop9h 25m
Deal found 9/15![United Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:00 am -
1 stop12h 38m
Thu 11/510:00 am -
1 stop10h 34m
Deal found 9/14![United Airlines logo]()
$667
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:18 pm -
1 stop25h 44m
Sun 11/1510:00 am -
1 stop13h 30m
Deal found 9/14![United Airlines logo]()
$670
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:40 pm -
2 stops21h 05m
Mon 1/114:41 pm -
2 stops20h 39m
Deal found 9/16![United Airlines logo]()
$678
Best flights from Louisville to Panama CityDiscover carefully curated flight deals from Louisville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Louisville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:15 am -
1 stop13h 47m
Tue 12/811:35 am -
1 stop10h 24m
Deal found 9/16![United Airlines logo]()
$627
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:57 pm -
2 stops26h 05m
Tue 12/110:00 am -
1 stop13h 59m
Deal found 9/17![United Airlines logo]()
$631
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/17:05 am -
1 stop12h 33m
Sun 3/711:55 pm -
1 stop17h 35m
Deal found 9/13![United Airlines logo]()
$641
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:10 am -
1 stop8h 02m
Sat 12/124:41 pm -
2 stops23h 58m
Deal found 9/15![United Airlines logo]()
$665
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:15 am -
1 stop8h 47m
Thu 11/54:41 pm -
2 stops20h 54m
Deal found 9/14![United Airlines logo]()
$671
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:45 pm -
1 stop30h 17m
Sun 11/154:41 pm -
2 stops20h 54m
Deal found 9/14![United Airlines logo]()
$675
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:10 am -
1 stop10h 28m
Mon 1/114:41 pm -
2 stops23h 51m
Deal found 9/16![United Airlines logo]()
$678
Last-minute flights from Louisville to Panama CityDiscover last-minute flight deals from Louisville to Panama City. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Louisville to Panama City. Data last updated September 18, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:15 am -
2 stops14h 22m
Mon 9/283:30 pm -
2 stops25h 10m
Deal found 9/17![United Airlines logo]()
$751
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop7h 26m
Mon 9/281:16 pm -
1 stop9h 28m
Deal found 9/17![American Airlines logo]()
$781
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:27 pm -
2 stops17h 49m
Sun 10/41:16 pm -
2 stops19h 16m
Deal found 9/15![American Airlines logo]()
$790
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop8h 02m
Fri 10/302:02 pm -
1 stop8h 43m
Deal found 9/14![American Airlines logo]()
$764
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:00 am -
1 stop12h 38m
Thu 11/510:00 am -
1 stop10h 34m
Deal found 9/14![United Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:04 am -
2 stops8h 58m
Fri 11/63:13 pm -
2 stops19h 34m
Deal found 9/15![American Airlines logo]()
$691
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:40 am -
1 stop14h 22m
Sat 11/78:55 am -
1 stop11h 38m
Deal found 9/16![United Airlines logo]()
$752
One-way flights from Louisville to Panama CitySearch for one-way flight options from Louisville to Panama City. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Louisville to Panama City. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:37 am -
2 stops28h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$286
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:02 am -
1 stop8h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/165:46 pm -
2 stops19h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![American Airlines logo]()
$315
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/165:57 pm -
2 stops23h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![United Airlines logo]()
$320
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:10 am -
2 stops13h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![United Airlines logo]()
$402
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:30 pm -
1 stop26h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![United Airlines logo]()
$406
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:15 am -
2 stops14h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![United Airlines logo]()
$422
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:06 am -
2 stops8h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:05 am -
1 stop6h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Delta logo]()
$437
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:06 pm -
3 stops28h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$479
Find flight deals from Louisville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $607 (United Airlines) |
One-way from | $286 (United Airlines) |
Popular in | July |
Cheapest in | February |
Average price | $720 |
Cheapflights Fare Finder
Customize your flight search to find flights from Louisville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Louisville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Wed 11/4
10:37 am-2:45 pm
2 stops28h 08m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$286
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Sat 1/16
5:46 pm-1:36 pm
2 stops19h 50m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$315
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Sat 1/16
5:57 pm-5:12 pm
2 stops23h 15m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$320
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Thu 9/24
7:25 am-6:37 pm
1 stop12h 12m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$402
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Wed 9/23
5:15 am-6:37 pm
2 stops14h 22m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$402
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Tue 9/22
7:25 am-6:37 pm
1 stop12h 12m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$402
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Sun 10/4
6:30 pm-7:31 pm
1 stop26h 01m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$406
Quickest round-trip
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Sun 10/4
5:06 am-12:16 pm
2 stops8h 10m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$424
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Tue 12/15
9:10 am-2:10 am
2 stops17h 00m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$536
LouisvillePanama City
SDF Louisville Intl - PTY Panama City Tocumen Intl
SDFPTY
Louisville Intl
Tue 12/1
6:15 am-8:02 pm
1 stop13h 47m
Panama City Tocumen Intl
Tue 12/8
11:35 am-9:59 pm
1 stop10h 24m
$627
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Louisville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Louisville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Louisville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Louisville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Louisville with our price prediction graph.
SDF-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Louisville to Panama City
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 18, 2026.
Read through reviews of airlines operating flights from Louisville to Panama City, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Overall
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Entertainment
7.8
Comfort
7.8
Overall
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Entertainment
7.8
Comfort
7.8
Overall
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Entertainment
7.8
Comfort
7.8
Overall
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Louisville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Louisville to Panama City
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Louisville to Panama City by cabin class
Find flights from Louisville to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Louisville and Panama City flights
Browse other Louisville and Panama City flight options. Last updated on September 18, 2026.
Other flights from Louisville
Browse through other flights departing from Louisville. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Louisville to Panama City
Discover the top 3 airlines that operate flights from Louisville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$430 | Average$568 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$514 | Average$749 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$558 | Average$680 | FlexibilityNo cancel fee | On-timeN/A |