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Panama City

$342+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:00 amDSM - PTY
1 stop8h 42mAmerican Airlines
Wed 12/172:50 pmPTY - DSM
1 stop9h 39mAmerican Airlines
Deal found 10/26$461
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/78:15 amDSM - PTY
1 stop10h 23mUnited Airlines
Sun 12/148:55 amPTY - DSM
1 stop14h 34mUnited Airlines
Deal found 10/27$462
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:05 amDSM - PTY
1 stop7h 40mUnited Airlines
Thu 11/274:41 pmPTY - DSM
2 stops25h 44mUnited Airlines
Deal found 10/28$466
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:50 pmDSM - PTY
2 stops18h 55mUnited Airlines
Fri 12/194:41 pmPTY - DSM
1 stop30h 49mUnited Airlines
Deal found 10/28$475
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:15 amDSM - PTY
1 stop10h 23mUnited Airlines
Thu 12/188:55 amPTY - DSM
1 stop14h 35mUnited Airlines
Deal found 10/27$482
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/223:15 pmDSM - PTY
2 stops22h 30mUnited Airlines
Fri 11/284:41 pmPTY - DSM
2 stops19h 01mUnited Airlines
Deal found 10/26$550
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/206:05 amDSM - PTY
1 stop7h 40mUnited Airlines
Mon 11/248:55 amPTY - DSM
1 stop14h 25mUnited Airlines
Deal found 10/26$576

Cheap flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$461
(American Airlines)

One-way from

$342
(United Airlines)

Popular in

June

Cheapest in

December

Average price

$583
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
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From Des Moines to Panama City Tocumen Intl
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One-way flight from Des Moines to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($106 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($44 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 12/10

6:00 am-3:42 pm

1 stop8h 42m

Panama City Tocumen Intl

Wed 12/17

2:50 pm-11:29 pm

1 stop9h 39m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 12/10

8:15 am-7:38 pm

1 stop10h 23m

Panama City Tocumen Intl

Wed 12/17

11:35 am-10:29 pm

1 stop11h 54m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 12/7

8:15 am-7:38 pm

1 stop10h 23m

Panama City Tocumen Intl

Sun 12/14

8:55 am-10:29 pm

1 stop14h 34m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

8:08 am-7:38 pm

1 stop10h 30m

Panama City Tocumen Intl

Fri 3/6

8:55 am-10:36 pm

1 stop14h 41m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 12/11

4:07 pm-1:47 pm

2 stops20h 40m

Panama City Tocumen Intl

Thu 12/18

2:53 pm-11:58 pm

1 stop10h 05m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 1/17

5:51 pm-3:38 pm

2 stops20h 47m

Panama City Tocumen Intl

Sat 2/7

2:27 pm-11:12 am

2 stops21h 45m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

7:46 pm-3:14 pm

2 stops18h 28m

Panama City Tocumen Intl

Sat 3/7

2:52 pm-10:08 am

2 stops20h 16m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 12/11

8:15 am-5:07 pm

1 stop7h 52m

$342

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

6:20 pm-12:10 pm

2 stops17h 50m

$348

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/13

3:00 pm-4:07 pm

1 stop25h 07m

$535

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, December is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $401). Flying from Des Moines to Panama City in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 28, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City?

    A quick flight from Des Moines to Panama City can take about 8h 42m. American Airlines provides one of the quickest options available for as low as $461. The distance from Des Moines to Panama City is about 2405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Panama City round-trip?

    United Airlines, at $414, was found to be the cheapest airline from Des Moines to Panama City.Alternate airlines to your destination round-trip include Delta and American Airlines. United Airlines is 29% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City?

    Currently, December is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $401). Flying from Des Moines to Panama City in March is currently the most expensive (average of $604). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Panama City

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Top 3 airlines flying from Des Moines to Panama City

Discover the top 3 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$414Average$486FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$581FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$445Average$572FlexibilityNo cancel feeOn-time71%

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