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Panama City

$198+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
ene. 11 — ene. 181
dom. 1/11
dom. 1/18
1 adult, Economy
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Cheap flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.

This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/135:34 amDSM - PTY
1 stop13h 25mDelta
vie. 12/268:00 amPTY - DSM
1 stop10h 15mDelta
Deal found 12/10$462
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:46 pmDSM - PTY
2 stops21h 21mUnited Airlines
lun. 3/233:41 pmPTY - DSM
2 stops21h 42mUnited Airlines
Deal found 12/11$508
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:52 pmDSM - PTY
2 stops20h 02mAmerican Airlines
lun. 3/231:39 pmPTY - DSM
2 stops23h 31mAmerican Airlines
Deal found 12/10$561

Find flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated diciembre 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$462
(United Airlines)

One-way from

$198
(United Airlines)

Popular in

June

Cheapest in

September

Average price

$1,033
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
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From Des Moines to Panama City Tocumen Intl
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One-way flight from Des Moines to Panama City Tocumen Intl
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Highest demand for flights based on searches. 9% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($41 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

vie. 1/23

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

mié. 1/28

8:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

vie. 1/23

8:00 am-7:38 pm

2 stops10h 38m

Panama City Tocumen Intl

vie. 1/30

11:35 am-10:30 pm

1 stop11h 55m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

lun. 1/19

8:10 am-7:38 pm

1 stop10h 28m

Panama City Tocumen Intl

jue. 1/22

8:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

jue. 2/26

8:08 am-7:38 pm

1 stop10h 30m

Panama City Tocumen Intl

sáb. 3/7

8:55 am-10:44 pm

1 stop14h 49m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mar. 2/24

8:08 am-7:38 pm

1 stop10h 30m

Panama City Tocumen Intl

vie. 3/6

8:55 am-10:44 pm

1 stop14h 49m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

lun. 1/26

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

lun. 2/2

8:55 am-10:30 pm

1 stop14h 35m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

sáb. 1/24

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

sáb. 1/31

4:41 pm-2:33 pm

2 stops22h 52m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

mié. 4/22

3:15 pm-2:14 pm

2 stops22h 59m

Panama City Tocumen Intl

dom. 4/26

10:55 pm-9:52 pm

2 stops22h 57m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

dom. 1/25

6:48 pm-5:07 pm

2 stops21h 19m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

vie. 3/13

1:40 pm-12:40 pm

2 stops23h 00m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Showing 1-10 of 12 results
1
2

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $411). Flying from Des Moines to Panama City in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated diciembre 12, 2025.
See what other customers who have flown with Delta and United Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Food

7.3

Boarding

8.1

Comfort

7.9

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City?

    A quick flight from Des Moines to Panama City can take about 7h 57m. United Airlines provides one of the quickest options available for as low as $462. The distance from Des Moines to Panama City is about 2405 mi.

  • What are the cheapest airlines flying from Des Moines to Panama City round-trip?

    United Airlines, at $420, was found to be the cheapest airline from Des Moines to Panama City. An alternate airline flying to your destination would be Delta. United Airlines is 33% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $411). Flying from Des Moines to Panama City in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 2 airlines flying from Des Moines to Panama City

Discover the top 2 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$420Average$485FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$581FlexibilityNo cancel feeOn-timeN/A

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