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Panama City

$299+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:52 am
DSM
-
PTY
1 stop8h 15m
United Airlines
Sat 3/78:55 am
PTY
-
DSM
1 stop14h 49m
United Airlines
Deal found 1/26$483
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/98:10 am
DSM
-
PTY
1 stop7h 57m
United Airlines
Fri 2/134:41 pm
PTY
-
DSM
1 stop30h 34m
United Airlines
Deal found 1/26$492
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/303:35 pm
DSM
-
PTY
2 stops22h 10m
United Airlines
Sun 2/14:41 pm
PTY
-
DSM
1 stop30h 49m
United Airlines
Deal found 1/26$497
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:20 am
DSM
-
PTY
1 stop7h 52m
United Airlines
Tue 4/147:55 am
PTY
-
DSM
1 stop14h 48m
United Airlines
Deal found 1/25$515
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:10 pm
DSM
-
PTY
2 stops14h 54m
United Airlines
Sun 4/263:30 pm
PTY
-
DSM
2 stops20h 59m
United Airlines
Deal found 1/27$519
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:00 pm
DSM
-
PTY
2 stops19h 36m
American Airlines
Sun 5/31:49 pm
PTY
-
DSM
2 stops21h 39m
American Airlines
Deal found 1/27$524
This Ovago deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/308:00 am
DSM
-
PTY
2 stops10h 38m
Copa Airlines
Sun 2/18:55 am
PTY
-
DSM
2 stops37h 55m
Copa Airlines
Deal found 1/26$556
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:44 pm
DSM
-
PTY
2 stops18h 36m
American Airlines
Mon 3/231:40 pm
PTY
-
DSM
2 stops19h 21m
American Airlines
Deal found 1/27$562
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/262:02 pm
DSM
-
PTY
2 stops22h 38m
American Airlines
Sat 3/74:05 pm
PTY
-
DSM
2 stops26h 55m
American Airlines
Deal found 1/26$576
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/44:00 pm
DSM
-
PTY
2 stops20h 27m
American Airlines
Sun 2/84:50 pm
PTY
-
DSM
2 stops23h 25m
American Airlines
Deal found 1/25$602
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:15 am
DSM
-
PTY
1 stop8h 52m
United Airlines
Tue 3/173:41 pm
PTY
-
DSM
1 stop22h 37m
United Airlines
Deal found 1/25$615

Find flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$483
(United Airlines)

One-way from

$299
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$453
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Des Moines to Panama City Tocumen Intl
Search Deals
One-way flight from Des Moines to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($117 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($42 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Tue 3/3

8:55 am-10:20 pm

1 stop14h 25m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 4/22

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

Mon 4/27

7:55 am-10:43 pm

1 stop14h 48m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 4/27

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

Mon 5/4

10:00 am-10:45 pm

1 stop12h 45m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 4/21

8:20 am-4:12 pm

1 stop7h 52m

Panama City Tocumen Intl

Mon 4/27

7:55 am-10:43 pm

1 stop14h 48m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 4/11

8:20 am-6:37 pm

1 stop10h 17m

Panama City Tocumen Intl

Tue 4/14

7:55 am-10:43 pm

1 stop14h 48m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 2/26

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Sat 3/7

8:55 am-10:44 pm

1 stop14h 49m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 2/24

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Fri 3/6

8:55 am-10:44 pm

1 stop14h 49m

$483

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 2/25

7:52 am-7:38 pm

1 stop10h 46m

Panama City Tocumen Intl

Mon 3/2

4:41 pm-2:27 pm

2 stops22h 46m

$487

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/9

8:10 am-5:07 pm

1 stop7h 57m

Panama City Tocumen Intl

Fri 2/13

4:41 pm-10:53 am

2 stops19h 12m

$487

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 3/11

7:44 pm-2:20 pm

2 stops18h 36m

$299

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 14 results
1
2

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $411). Flying from Des Moines to Panama City in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated January 27, 2026.
See what other customers who have flown with Delta and United Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,119 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,119 reviews
Delta
7.9
Good
8,119 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,205 reviews
Delta
7.9
Good
8,119 reviews

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City?

    A quick flight from Des Moines to Panama City can take about 10h 46m. United Airlines provides one of the quickest options available for as low as $483. The distance from Des Moines to Panama City is about 2405 mi.

  • What are the cheapest airlines flying from Des Moines to Panama City round-trip?

    United Airlines, at $435, was found to be the cheapest airline from Des Moines to Panama City. An alternate airline flying to your destination would be Delta. United Airlines is 23% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $411). Flying from Des Moines to Panama City in December is currently the most expensive (average of $729). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Des Moines to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Des Moines to Panama City

Discover the top 2 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$435Average$481FlexibilityNo cancel feeOn-time69%
DeltaCheapest$441Average$557FlexibilityNo cancel feeOn-timeN/A

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