How long is the flight from Des Moines to Panama City?

A quick flight from Des Moines to Panama City can take about 12h 22m. United Airlines provides one of the quickest options available for as low as $461. The distance from Des Moines to Panama City is about 2405 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Des Moines to Panama City round-trip?

United Airlines, at $411, was found to be the cheapest airline from Des Moines to Panama City.Alternate airlines to your destination round-trip include Delta and American Airlines. United Airlines is 32% cheaper than the average price of flights available within the next 90 days to this destination.

What is the cheapest day to fly from Des Moines to Panama City?

Travelers seeking maximum savings on their Des Moines to Panama City flight should consider departing on Sunday mornings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular airlines that fly from Des Moines to Panama City?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from Des Moines to Panama City.

What is the cheapest day to fly round-trip from Des Moines to Panama City?

Flying to your destination on a Monday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to Panama City. Check prices with Cheapflights to find a great deal for your trip.

What is the cheapest month to fly from Des Moines to Panama City?

Our data shows that December tends to be the cheapest month to fly to Panama City from Des Moines. Users have commonly found prices around $605 for the month, but tickets can be as low as $401. Due to multiple factors, prepare for potentially higher prices in June.

What is the cheapest time of day to fly from DSM to PTY?

It’s optimal to fly from Des Moines to Panama City at noon. By choosing this option you can save up to 19% on the cost of your flight, compared to a flight in the morning.

Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

Can I find deals for business class flights from Des Moines to Panama City?

Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$198+ Cheap Flights from Des Moines to Panama City

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Cheap flight deals from Des Moines to Panama City

Round-trip from	$461 (United Airlines)
One-way from	$198 (United Airlines)
Popular in	June
Cheapest in	December
Average price	$441

From Des Moines to Panama City Tocumen Intl

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One-way flight from Des Moines to Panama City Tocumen Intl

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Highest demand for flights based on searches. 12% potential increase in price ($88 potential increase over avg. RT price).

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Cheapest flight prices on average. 7% potential price decrease ($43 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Sun 10/126:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Sat 10/1810:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/11

$461

Sat 10/118:00 amDSM - PTY

2 stops10h 37mUnited Airlines

Sat 10/183:30 pmPTY - DSM

2 stops20h 49mUnited Airlines

Deal found 9/11

$466

Sat 10/113:05 pmDSM - PTY

1 stop27h 32mUnited Airlines

Tue 10/2110:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/11

$470

Sat 10/113:05 pmDSM - PTY

1 stop23h 09mUnited Airlines

Mon 10/203:30 pmPTY - DSM

1 stop22h 43mUnited Airlines

Deal found 9/11

$479

Fri 10/105:56 pmDSM - PTY

2 stops43h 00mDelta

Wed 10/222:21 pmPTY - DSM

2 stops23h 38mDelta

Deal found 9/11

$481

Fri 10/105:56 pmDSM - PTY

2 stops43h 00mDelta

Thu 10/232:21 pmPTY - DSM

1 stop19h 44mDelta

Deal found 9/11

$490

Wed 10/156:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Fri 10/1710:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/11

$503

Thu 10/166:30 amDSM - PTY

2 stops12h 07mUnited Airlines

Tue 10/213:30 pmPTY - DSM

2 stops19h 02mUnited Airlines

Deal found 9/11

$508

Tue 10/146:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Mon 10/203:30 pmPTY - DSM

1 stop22h 43mUnited Airlines

Deal found 9/11

$512

Sun 10/1211:06 amDSM - PTY

2 stops25h 50mDelta

Tue 10/212:21 pmPTY - DSM

1 stop8h 09mDelta

Deal found 9/11

$513

Sat 10/113:05 pmDSM - PTY

1 stop27h 32mUnited Airlines

Sun 10/193:30 pmPTY - DSM

2 stops22h 53mUnited Airlines

Deal found 9/11

$517

Best flights from Des Moines to Panama City
Discover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2025.

Thu 10/166:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Mon 10/2010:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/10

$461

Mon 10/66:39 pmDSM - PTY

1 stop18h 17mDelta

Wed 10/82:21 pmPTY - DSM

1 stop8h 09mDelta

Deal found 9/10

$461

Sun 10/126:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Mon 10/2010:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/10

$461

Sun 10/55:44 amDSM - PTY

1 stop7h 11mDelta

Wed 10/82:21 pmPTY - DSM

1 stop8h 09mDelta

Deal found 9/10

$461

Tue 10/76:15 amDSM - PTY

1 stop7h 59mUnited Airlines

Fri 10/1010:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/10

$461

Mon 10/65:47 amDSM - PTY

1 stop7h 09mDelta

Fri 10/102:21 pmPTY - DSM

2 stops23h 38mDelta

Deal found 9/10

$466

Mon 10/66:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Fri 10/1010:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/10

$461

Tue 10/146:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Fri 10/1710:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/10

$461

Thu 10/166:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Tue 10/213:30 pmPTY - DSM

2 stops22h 53mUnited Airlines

Deal found 9/11

$466

Sat 10/116:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Thu 10/233:30 pmPTY - DSM

2 stops20h 49mUnited Airlines

Deal found 9/10

$466

Sat 10/116:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Sat 10/183:30 pmPTY - DSM

2 stops20h 49mUnited Airlines

Deal found 9/10

$466

Tue 10/76:15 amDSM - PTY

1 stop7h 59mUnited Airlines

Wed 10/83:30 pmPTY - DSM

2 stops19h 02mUnited Airlines

Deal found 9/10

$466

Last-minute flights from Des Moines to Panama City
Discover last-minute flight deals from Des Moines to Panama City. Data last updated September 11, 2025 and is based on user searches.

Fri 10/105:56 pmDSM - PTY

2 stops43h 00mDelta

Wed 10/222:21 pmPTY - DSM

2 stops23h 38mDelta

Deal found 9/11

$481

Fri 10/105:56 pmDSM - PTY

2 stops43h 00mDelta

Thu 10/232:21 pmPTY - DSM

1 stop19h 44mDelta

Deal found 9/11

$490

Sat 10/118:00 amDSM - PTY

2 stops10h 37mUnited Airlines

Fri 10/173:30 pmPTY - DSM

2 stops19h 02mUnited Airlines

Deal found 9/11

$466

Sat 10/113:05 pmDSM - PTY

1 stop23h 09mUnited Airlines

Sat 10/183:30 pmPTY - DSM

2 stops19h 02mUnited Airlines

Deal found 9/11

$475

Sat 10/113:05 pmDSM - PTY

1 stop23h 09mUnited Airlines

Mon 10/203:30 pmPTY - DSM

1 stop22h 43mUnited Airlines

Deal found 9/11

$479

Sat 10/113:05 pmDSM - PTY

1 stop27h 32mUnited Airlines

Sun 10/193:30 pmPTY - DSM

2 stops22h 53mUnited Airlines

Deal found 9/11

$517

Sun 10/126:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Fri 10/1710:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/11

$461

Sun 10/1211:06 amDSM - PTY

2 stops25h 50mDelta

Tue 10/212:21 pmPTY - DSM

1 stop8h 09mDelta

Deal found 9/11

$513

Tue 10/146:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Mon 10/203:30 pmPTY - DSM

1 stop22h 43mUnited Airlines

Deal found 9/11

$512

Wed 10/156:15 amDSM - PTY

1 stop12h 22mUnited Airlines

Fri 10/1710:00 amPTY - DSM

1 stop12h 28mUnited Airlines

Deal found 9/11

$503

Thu 10/166:30 amDSM - PTY

2 stops12h 07mUnited Airlines

Mon 10/203:30 pmPTY - DSM

2 stops19h 02mUnited Airlines

Deal found 9/11

$508

One-way flights from Des Moines to Panama City
Search for one-way flight options from Des Moines to Panama City. Find affordable one-way fares based on user searches. Data last updated September 11, 2025.

Sun 10/266:05 amDSM - PTY

1 stop12h 33mUnited Airlines

Deal found 9/10

$198

Sun 10/266:22 pmDSM - PTY

2 stops19h 41mAmerican Airlines

Deal found 9/10

$204

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/20

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 10/6

6:39 pm-12:56 pm

1 stop18h 17m

Panama City Tocumen Intl

Wed 10/8

2:21 pm-10:30 pm

1 stop8h 09m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/20

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/5

5:44 am-12:55 pm

1 stop7h 11m

Panama City Tocumen Intl

Wed 10/8

2:21 pm-10:30 pm

1 stop8h 09m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 10/7

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Fri 10/10

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 10/6

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Fri 10/10

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 10/14

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Fri 10/17

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 10/6

5:47 am-12:56 pm

1 stop7h 09m

Panama City Tocumen Intl

Fri 10/10

2:21 pm-1:59 pm

2 stops23h 38m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Thu 10/16

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Tue 10/21

3:30 pm-2:23 pm

2 stops22h 53m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 10/11

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Thu 10/23

3:30 pm-12:19 pm

2 stops20h 49m

$466

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 14 results

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $478). Flying from Des Moines to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,960 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,937 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,960 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

How long is the flight from Des Moines to Panama City?
A quick flight from Des Moines to Panama City can take about 12h 22m. United Airlines provides one of the quickest options available for as low as $461. The distance from Des Moines to Panama City is about 2405 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Des Moines to Panama City round-trip?
United Airlines, at $411, was found to be the cheapest airline from Des Moines to Panama City.Alternate airlines to your destination round-trip include Delta and American Airlines. United Airlines is 32% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Des Moines to Panama City that include hotel bookings?
Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.
Can I find deals for business class flights from Des Moines to Panama City?
Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Panama City?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $478). Flying from Des Moines to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

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Other flights to Panama City

Top 3 airlines flying from Des Moines to Panama City

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$411	Average$484	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$441	Average$581	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$445	Average$544	FlexibilityNo cancel fee	On-time71%

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$198+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Des Moines to Panama City

Round-trip from

One-way from

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Cheapest in

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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama CityExplore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Reviews of airlines servicing Panama City

See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Des Moines to Panama City?

What are the cheapest airlines flying from Des Moines to Panama City round-trip?

Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

How can I find direct flights from Des Moines to Panama City?

Can I find deals for business class flights from Des Moines to Panama City?

What is the cheapest month to book a flight from Des Moines to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Des Moines to Panama City

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Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.