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$198+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
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Cheap flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 30, 2025.

Round-trip from

$461
(United Airlines)

One-way from

$198
(Delta)

Popular in

June

Cheapest in

September

Average price

$455
From Des Moines to Panama City Tocumen Intl
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One-way flight from Des Moines to Panama City Tocumen Intl
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Highest demand for flights based on searches. 13% potential increase in price ($96 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($43 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/126:15 amDSM - PTY
1 stop12h 22mUnited Airlines
Mon 10/2010:00 amPTY - DSM
1 stop12h 28mUnited Airlines
Deal found 7/28$461
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:12 pmDSM - PTY
2 stops20h 19mAmerican Airlines
Sat 9/203:31 pmPTY - DSM
2 stops26h 08mAmerican Airlines
Deal found 7/30$462
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/102:40 pmDSM - PTY
2 stops22h 16mDelta
Thu 10/232:21 pmPTY - DSM
2 stops18h 59mDelta
Deal found 7/28$466
This Trip.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:15 amDSM - PTY
1 stop7h 59mMultiple Airlines
Fri 9/193:25 amPTY - DSM
2 stops18h 20mMultiple Airlines
Deal found 7/30$679

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 10/12

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 10/20

10:00 am-10:28 pm

1 stop12h 28m

$461

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 9/13

6:12 pm-2:31 pm

2 stops20h 19m

Panama City Tocumen Intl

Sat 9/20

3:31 pm-5:39 pm

2 stops26h 08m

$462

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 10/10

2:40 pm-12:56 pm

2 stops22h 16m

Panama City Tocumen Intl

Thu 10/23

2:21 pm-9:20 am

2 stops18h 59m

$466

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 9/13

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Fri 9/19

3:25 am-9:45 pm

2 stops18h 20m

$679

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 9/12

5:44 am-12:55 pm

1 stop7h 11m

$198

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 9/12

1:10 pm-6:13 am

3 stops17h 03m

$3,645

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $478). Flying from Des Moines to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated July 30, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Panama City round-trip?

    United Airlines, at $461, was found to be the cheapest airline from Des Moines to Panama City.Alternate airlines to your destination round-trip include American Airlines and Delta. United Airlines is 22% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $478). Flying from Des Moines to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Des Moines to Panama City

Discover the top 3 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$349Average$557FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$379Average$483FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$445Average$572FlexibilityNo cancel feeOn-time71%

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