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$194+ Cheap flights from Des Moines (DSM) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2025.

Round-trip from

$460
(Trip.com)

One-way from

$194
(United Airlines)

Popular in

June

Cheapest in

September

Average price

$1,069
From Des Moines to Panama City Tocumen Intl
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One-way flight from Des Moines to Panama City Tocumen Intl
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Highest demand for flights based on searches. 15% potential increase in price ($104 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($44 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This Trip.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/236:02 amDSM - PTY
1 stop10h 10mUnited Airlines
Wed 7/307:55 amPTY - DSM
1 stop14h 22mUnited Airlines
Deal found 6/11$460
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/294:26 pmDSM - PTY
2 stops19h 54mAmerican Airlines
Sat 12/62:45 pmPTY - DSM
1 stop9h 59mAmerican Airlines
Deal found 6/10$556
This Kissandfly.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/256:24 amDSM - PTY
2 stops12h 13mLufthansa
Fri 8/17:55 amPTY - DSM
2 stops13h 52mLufthansa
Deal found 6/10$609
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2311:00 amDSM - PTY
3 stops29h 39mMultiple Airlines
Wed 7/305:25 pmPTY - DSM
3 stops29h 13mMultiple Airlines
Deal found 6/10$629
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:14 amDSM - PTY
1 stop7h 48mDelta
Wed 12/313:20 pmPTY - DSM
1 stop8h 03mDelta
Deal found 6/10$941
This Gotogate deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/98:00 amDSM - PTY
2 stops37h 10mAvianca
Tue 7/153:20 amPTY - DSM
2 stops18h 27mAvianca
Deal found 6/11$2,312

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 7/23

6:02 am-4:12 pm

1 stop10h 10m

Panama City Tocumen Intl

Wed 7/30

7:55 am-10:17 pm

1 stop14h 22m

$460

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 11/29

4:26 pm-1:20 pm

2 stops19h 54m

Panama City Tocumen Intl

Sat 12/6

2:45 pm-11:44 pm

1 stop9h 59m

$556

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 7/25

6:24 am-6:37 pm

2 stops12h 13m

Panama City Tocumen Intl

Fri 8/1

7:55 am-9:47 pm

2 stops13h 52m

$609

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 7/23

11:00 am-4:39 pm

3 stops29h 39m

Panama City Tocumen Intl

Wed 7/30

5:25 pm-10:38 pm

3 stops29h 13m

$629

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Wed 7/9

8:00 am-9:10 pm

2 stops37h 10m

Panama City Tocumen Intl

Tue 7/15

3:20 am-9:47 pm

2 stops18h 27m

$2,312

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 7/25

6:02 am-4:12 pm

1 stop10h 10m

$194

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 7/25

6:30 am-4:30 pm

3 stops34h 00m

$265

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

What is the cheapest month to book a flight from Des Moines to Panama City?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $478). Flying from Des Moines to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to PTY?

Find hourly flight availability from Des Moines to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

It’s optimal to fly from Des Moines to Panama City at noon. By choosing this option you can save up to 19% on the cost of your flight, compared to a flight in the morning.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 12, 2025.
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,790 reviews
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
Lufthansa
6.8
Okay
7,136 reviews
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
Avianca
6.7
Okay
2,345 reviews
United Airlines
7.4
Good
8,790 reviews

Entertainment

7.0

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Panama City round-trip?

    United Airlines, at $460, was found to be the cheapest airline from Des Moines to Panama City.Alternate airlines to your destination round-trip include American Airlines and Lufthansa. United Airlines is 21% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama City (average of $478). Flying from Des Moines to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Panama City

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Top 3 airlines flying from Des Moines to Panama City

Discover the top 3 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$349Average$556FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$354Average$544FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$359Average$469FlexibilityNo cancel feeOn-time69%

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