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Panama City Beach

$140+ Cheap flights from Knoxville (TYS) to Panama City Beach, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PNS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Knoxville to Panama City Beach

Cheapest flights from Knoxville to Panama City Beach
Explore the most affordable flight options available from Knoxville to Panama City Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/203:53 pmTYS - ECP
1 stop5h 39mDelta
Sun 11/236:40 pmECP - TYS
1 stop4h 01mDelta
Deal found 10/28$347
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:00 amTYS - ECP
1 stop3h 56mAmerican Airlines
Wed 12/2411:11 amECP - TYS
1 stop4h 12mAmerican Airlines
Deal found 10/30$377
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:15 amTYS - ECP
1 stop3h 04mDelta
Wed 11/129:23 amECP - TYS
1 stop4h 25mDelta
Deal found 10/29$421
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:30 amTYS - ECP
1 stop4h 30mAmerican Airlines
Thu 11/137:15 amECP - TYS
1 stop4h 44mAmerican Airlines
Deal found 10/30$506
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/65:05 amTYS - ECP
1 stop6h 28mAmerican Airlines
Sun 11/97:15 amECP - TYS
1 stop4h 44mAmerican Airlines
Deal found 10/29$525
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:51 pmTYS - ECP
1 stop6h 58mAmerican Airlines
Sun 11/162:37 pmECP - TYS
1 stop3h 56mAmerican Airlines
Deal found 10/29$602
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/209:10 amTYS - ECP
1 stop25h 09mUnited Airlines
Sun 11/235:04 pmECP - TYS
2 stops28h 51mUnited Airlines
Deal found 10/28$697
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:30 amTYS - ECP
1 stop4h 30mAmerican Airlines
Wed 11/128:21 amECP - TYS
2 stops12h 03mAmerican Airlines
Deal found 10/29$749
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:45 amTYS - ECP
2 stops16h 04mUnited Airlines
Sun 11/166:30 amECP - TYS
1 stop16h 14mUnited Airlines
Deal found 10/29$762

Cheap flight deals from Knoxville to Panama City Beach

Keep the following information in mind while searching for Knoxville to Panama City Beach flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$347
(Delta)

One-way from

$140
(Southwest)

Popular in

November

Cheapest in

August

Average price

$459
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
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From Knoxville McGhee Tyson to Panama City Beach
Search Deals
One-way flight from Knoxville McGhee Tyson to Panama City Beach
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City Beach that are best for you.

Fly from

Knoxville

Fly to

Panama City Beach

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 11/20

3:53 pm-8:32 pm

1 stop5h 39m

Panama City NW Florida Beaches

Sun 11/23

6:40 pm-11:41 pm

1 stop4h 01m

$347

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 12/19

7:00 am-9:56 am

1 stop3h 56m

Panama City NW Florida Beaches

Wed 12/24

11:11 am-4:23 pm

1 stop4h 12m

$377

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 11/13

5:51 pm-11:49 pm

1 stop6h 58m

Panama City NW Florida Beaches

Sun 11/16

2:37 pm-7:33 pm

1 stop3h 56m

$602

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 11/20

9:10 am-9:19 am

1 stop25h 09m

Panama City NW Florida Beaches

Sun 11/23

5:04 pm-10:55 pm

2 stops28h 51m

$697

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 11/13

6:45 am-9:49 pm

2 stops16h 04m

Panama City NW Florida Beaches

Sun 11/16

6:30 am-11:44 pm

1 stop16h 14m

$762

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 12/26

5:40 pm-11:53 pm

1 stop7h 13m

Panama City NW Florida Beaches

Tue 12/30

11:11 am-6:00 pm

1 stop5h 49m

$787

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 3/18

6:35 am-9:35 am

1 stop4h 00m

$140

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 12/25

7:00 am-10:37 am

1 stop4h 37m

$299

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 11/14

5:36 pm-8:32 pm

1 stop3h 56m

$299

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 11/9

3:53 pm-5:55 pm

1 stop3h 02m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 15 results
1
2

Best time to book a flight from Knoxville to Panama City Beach

Have a flexible travel schedule? Discover the best time to fly to Panama City Beach from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City Beach

What is the cheapest month to book a flight from Knoxville to Panama City Beach?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City Beach (average of $57). Flying from Knoxville to Panama City Beach in February is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PA9?

Find hourly flight availability from Knoxville to Panama City Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Knoxville to Panama City Beach is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 40% on airfare.

What is the cheapest day to fly from Knoxville to Panama City Beach?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Panama City Beach. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Panama City Beach flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Panama City Beach

Get insights into the airlines that provide service to Panama City Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City Beach. Reviews last updated October 30, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Panama City Beach to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama City Beach?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Panama City Beach. On average, McGhee Tyson has 0 outbound flights to Panama City Beach per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Panama City Beach?

    Delta, American Airlines, and United Airlines can get you from Knoxville to Panama City Beach in just under 3h 56m. Your travel time can differ by up to 21h 13m. The distance between Knoxville and Panama City Beach is about 390 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Knoxville to Panama City Beach one-way?

    For one-way options, check prices for Southwest. According to our data, you can fly for as low as $140. Users have also found prices from $299 and $299 on American Airlines and Delta, respectively.

  • Can I find deals for flights from Knoxville to Panama City Beach that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City Beach.

  • Can I find deals for business class flights from Knoxville to Panama City Beach?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City Beach?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City Beach (average of $57). Flying from Knoxville to Panama City Beach in February is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Panama City Beach

Discover the top 3 airlines that operate flights from Knoxville to Panama City Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$67Average$117FlexibilityNo cancel feeOn-time88%
DeltaCheapest$238Average$444FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$253Average$467FlexibilityNo cancel feeOn-time71%

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