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Panama City Beach

$271+ Cheap flights from Knoxville (TYS) to Panama City Beach, FL

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PNS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City Beach

Cheapest flights from Knoxville to Panama City Beach
Explore the most affordable flight options available from Knoxville to Panama City Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:58 pmTYS - ECP
1 stop5h 17mDelta
Sat 12/278:02 amECP - TYS
1 stop4h 40mDelta
Deal found 12/16$409
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:40 pmTYS - ECP
1 stop7h 13mAmerican Airlines
Sun 12/214:09 pmECP - TYS
1 stop4h 49mAmerican Airlines
Deal found 12/15$525
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:29 pmTYS - ECP
1 stop5h 29mAmerican Airlines
Tue 12/3011:11 amECP - TYS
1 stop5h 49mAmerican Airlines
Deal found 12/17$717
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:28 pmTYS - ECP
2 stops24h 09mAmerican Airlines
Sat 12/274:09 pmECP - TYS
1 stop4h 49mAmerican Airlines
Deal found 12/16$794
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:23 pmTYS - ECP
2 stops19h 04mUnited Airlines
Fri 1/26:15 amECP - TYS
1 stop16h 27mUnited Airlines
Deal found 12/16$846
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 amTYS - ECP
2 stops16h 09mUnited Airlines
Sat 12/274:45 pmECP - TYS
2 stops28h 54mUnited Airlines
Deal found 12/16$916
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:00 amTYS - ECP
1 stop4h 37mAmerican Airlines
Fri 1/24:09 pmECP - TYS
1 stop6h 38mAmerican Airlines
Deal found 12/16$955
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:00 amTYS - ECP
1 stop15h 54mUnited Airlines
Tue 12/302:10 pmECP - TYS
2 stops23h 38mUnited Airlines
Deal found 12/17$1,003

Find flight deals from Knoxville to Panama City Beach

Keep the following information in mind while searching for Knoxville to Panama City Beach flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$271
(Delta)

Popular in

February

Cheapest in

August

Average price

$414
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
Search Deals
From Knoxville McGhee Tyson to Panama City Beach
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City Beach that are best for you.

Fly from

Knoxville

Fly to

Panama City Beach

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 1/15

5:40 am-9:12 am

1 stop4h 32m

Panama City NW Florida Beaches

Sun 1/18

6:00 am-10:15 am

1 stop3h 15m

$271

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 5/4

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Sun 5/10

6:00 am-2:05 pm

1 stop7h 05m

$279

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 5/7

2:45 pm-9:40 pm

1 stop7h 55m

Panama City NW Florida Beaches

Sun 5/10

1:50 pm-10:00 pm

1 stop7h 10m

$279

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 3/10

6:35 am-9:35 am

1 stop4h 00m

Panama City NW Florida Beaches

Sun 3/15

10:05 am-9:00 pm

1 stop9h 55m

$304

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 3/27

5:01 pm-9:19 pm

1 stop5h 18m

Panama City NW Florida Beaches

Tue 3/31

7:00 am-11:18 am

1 stop3h 18m

$317

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 2/10

11:58 am-2:56 pm

1 stop3h 58m

Panama City NW Florida Beaches

Sat 2/14

5:14 pm-11:52 pm

1 stop5h 38m

$317

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 6/7

7:05 am-9:30 am

1 stop3h 25m

Panama City NW Florida Beaches

Fri 6/12

7:50 am-12:00 pm

1 stop3h 10m

$319

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 12/25

12:18 pm-6:55 pm

1 stop7h 37m

$341

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 12/25

1:54 pm-6:15 pm

1 stop5h 21m

$369

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 12/27

6:59 pm-10:44 pm

1 stop4h 45m

$460

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 12 results
1
2

Best time to book a flight from Knoxville to Panama City Beach

Have a flexible travel schedule? Discover the best time to fly to Panama City Beach from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City Beach

What is the cheapest month to book a flight from Knoxville to Panama City Beach?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City Beach (average of $57). Flying from Knoxville to Panama City Beach in February is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PA9?

Find hourly flight availability from Knoxville to Panama City Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

One of the essential ways to save on airfare from Knoxville to Panama City Beach is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 41% on airfare.

What is the cheapest day to fly from Knoxville to Panama City Beach?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Panama City Beach. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Panama City Beach flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Knoxville to Panama City Beach?

Reviews of airlines servicing Panama City Beach

Get insights into the airlines that provide service to Panama City Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City Beach. Reviews last updated December 18, 2025.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Panama City Beach to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,005 reviews

Crew

8.5

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama City Beach?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Panama City Beach. On average, McGhee Tyson has 0 outbound flights to Panama City Beach per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Panama City Beach?

    Delta and Southwest can get you from Knoxville to Panama City Beach in just under 3h 30m. Your travel time can differ by up to 1h 02m. The distance between Knoxville and Panama City Beach is about 390 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Knoxville to Panama City Beach that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City Beach.

  • Can I find deals for business class flights from Knoxville to Panama City Beach?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City Beach?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City Beach (average of $57). Flying from Knoxville to Panama City Beach in February is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Panama City Beach

Discover the top 3 airlines that operate flights from Knoxville to Panama City Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$67Average$116FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$228Average$444FlexibilityNo cancel feeOn-time71%
DeltaCheapest$238Average$446FlexibilityNo cancel feeOn-timeN/A

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