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Panama City Beach

$117+ Cheap flights from Knoxville (TYS) to Panama City Beach, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PNS
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City Beach

Cheapest flights from Knoxville to Panama City Beach
Explore the most affordable flight options available from Knoxville to Panama City Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:35 am
TYS
-
ECP
1 stop4h 00m
Southwest
Wed 3/257:30 am
ECP
-
TYS
1 stop5h 10m
Southwest
Deal found 1/27$233
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:38 pm
TYS
-
ECP
1 stop5h 26m
Delta
Mon 3/2311:08 am
ECP
-
TYS
1 stop3h 58m
Delta
Deal found 1/27$235
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:35 am
TYS
-
ECP
1 stop3h 30m
Southwest
Thu 4/169:55 am
ECP
-
TYS
1 stop9h 25m
Southwest
Deal found 1/27$240
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:40 am
TYS
-
ECP
1 stop3h 30m
Southwest
Sat 4/2512:40 pm
ECP
-
TYS
1 stop4h 50m
Southwest
Deal found 1/27$257
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/12:25 pm
TYS
-
ECP
1 stop6h 35m
Southwest
Sat 4/412:25 pm
ECP
-
TYS
1 stop7h 40m
Southwest
Deal found 1/27$261
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:35 am
TYS
-
ECP
2 stops7h 35m
Southwest
Sun 4/55:25 am
ECP
-
TYS
2 stops6h 30m
Southwest
Deal found 1/28$266
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:35 am
TYS
-
ECP
2 stops12h 45m
Southwest
Wed 5/2010:10 am
ECP
-
TYS
2 stops8h 30m
Southwest
Deal found 1/28$272

Find flight deals from Knoxville to Panama City Beach

Keep the following information in mind while searching for Knoxville to Panama City Beach flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$233
(Southwest)

One-way from

$117
(American Airlines)

Popular in

February

Cheapest in

March

Average price

$452
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
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From Knoxville McGhee Tyson to Panama City Beach
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One-way flight from Knoxville McGhee Tyson to Panama City Beach
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($17 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City Beach that are best for you.

Fly from

Knoxville

Fly to

Panama City Beach

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 3/16

6:38 pm-9:22 pm

1 stop3h 44m

Panama City NW Florida Beaches

Tue 3/24

9:25 am-4:06 pm

1 stop5h 41m

$235

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 3/18

2:25 pm-8:00 pm

1 stop6h 35m

Panama City NW Florida Beaches

Wed 3/25

7:30 am-8:05 pm

2 stops11h 35m

$238

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 4/13

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Thu 4/16

9:55 am-9:15 pm

2 stops10h 20m

$240

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 5/15

6:35 am-3:35 pm

1 stop10h 00m

Panama City NW Florida Beaches

Wed 5/20

7:15 am-12:00 pm

1 stop3h 45m

$261

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 4/1

2:25 pm-8:00 pm

1 stop6h 35m

Panama City NW Florida Beaches

Sat 4/4

12:25 pm-9:05 pm

1 stop7h 40m

$261

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 4/19

6:40 am-3:30 pm

2 stops9h 50m

Panama City NW Florida Beaches

Sat 4/25

12:40 pm-6:30 pm

1 stop4h 50m

$262

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 6/16

2:45 pm-8:40 pm

1 stop6h 55m

Panama City NW Florida Beaches

Tue 6/23

7:40 am-12:05 pm

1 stop3h 25m

$279

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 5/23

7:45 am-5:50 pm

1 stop11h 05m

Panama City NW Florida Beaches

Sat 5/30

7:20 am-11:40 am

1 stop3h 20m

$284

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 2/24

5:47 pm-10:17 pm

1 stop5h 30m

$117

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 4/18

6:40 am-9:00 am

1 stop3h 20m

$118

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 17 results
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Best time to book a flight from Knoxville to Panama City Beach

Have a flexible travel schedule? Discover the best time to fly to Panama City Beach from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City Beach

What is the cheapest month to book a flight from Knoxville to Panama City Beach?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City Beach (average of $57). Flying from Knoxville to Panama City Beach in February is currently the most expensive (average of $285). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PA9?

Find hourly flight availability from Knoxville to Panama City Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

One of the essential ways to save on airfare from Knoxville to Panama City Beach is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Reviews of airlines servicing Panama City Beach

Get insights into the airlines that provide service to Panama City Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City Beach. Reviews last updated January 29, 2026.
Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Panama City Beach to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,128 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,128 reviews
Delta
7.9
Good
8,128 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,205 reviews
Delta
7.9
Good
8,128 reviews

Food

7.2

Boarding

8.1

Comfort

7.9

Crew

8.5

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama City Beach?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Panama City Beach. On average, McGhee Tyson has 0 outbound flights to Panama City Beach per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Panama City Beach?

    Southwest and Delta can get you from Knoxville to Panama City Beach in just under 4h. Your travel time can differ by up to 1h 26m. The distance between Knoxville and Panama City Beach is about 390 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Knoxville to Panama City Beach that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City Beach.

  • Can I find deals for business class flights from Knoxville to Panama City Beach?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City Beach?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City Beach (average of $57). Flying from Knoxville to Panama City Beach in February is currently the most expensive (average of $285). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to Panama City Beach

Discover the top 3 airlines that operate flights from Knoxville to Panama City Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$62Average$117FlexibilityNo cancel feeOn-time88%
DeltaCheapest$228Average$435FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$461FlexibilityNo cancel feeOn-time71%

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