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Panama City Beach

$125+ Cheap flights from Knoxville (TYS) to Panama City Beach, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PNS
Apr 22 — Apr 291
Mi 4/22
Mi 4/29
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City Beach

Cheapest flights from Knoxville to Panama City Beach
Explore the most affordable flight options available from Knoxville to Panama City Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on März 23, 2026.

This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 4/256:40 am
TYS
-
ECP
1 stop3h 20m
Southwest
Mi 4/297:55 am
ECP
-
TYS
1 stop5h 25m
Southwest
Deal found 3/18$263
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/276:55 pm
TYS
-
ECP
1 stop4h 00m
Southwest
Di 6/307:40 am
ECP
-
TYS
1 stop3h 25m
Southwest
Deal found 3/20$299
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 6/46:40 am
TYS
-
ECP
1 stop8h 35m
Southwest
Mo 6/86:55 am
ECP
-
TYS
1 stop7h 50m
Southwest
Deal found 3/20$303
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 5/307:45 am
TYS
-
ECP
1 stop11h 05m
Southwest
Sa 6/67:00 am
ECP
-
TYS
2 stops11h 35m
Southwest
Deal found 3/20$310
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/16:35 am
TYS
-
ECP
2 stops12h 45m
Southwest
Do 5/79:55 am
ECP
-
TYS
1 stop9h 25m
Southwest
Deal found 3/21$315
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 5/135:40 am
TYS
-
ECP
1 stop3h 50m
Delta
Mo 5/187:41 am
ECP
-
TYS
1 stop5h 52m
Delta
Deal found 3/19$316
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/66:55 pm
TYS
-
ECP
1 stop4h 00m
Southwest
Sa 6/138:30 am
ECP
-
TYS
1 stop11h 50m
Southwest
Deal found 3/20$323

Find flight deals from Knoxville to Panama City Beach

Keep the following information in mind while searching for Knoxville to Panama City Beach flight deals. Data was last updated März 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Southwest)

One-way from

$125
(Southwest)

Popular in

April

Cheapest in

January

Average price

$335
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
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From Knoxville McGhee Tyson to Panama City Beach
Search Deals
One-way flight from Knoxville McGhee Tyson to Panama City Beach
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated März 23, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sa 4/25

6:40 am-1:00 pm

2 stops7h 20m

Panama City NW Florida Beaches

Mi 4/29

10:10 am-7:40 pm

2 stops8h 30m

$273

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sa 5/30

7:45 am-5:50 pm

1 stop11h 05m

Panama City NW Florida Beaches

Sa 6/6

8:30 am-9:20 pm

1 stop11h 50m

$310

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mi 5/13

5:40 am-8:30 am

1 stop3h 50m

Panama City NW Florida Beaches

Mo 5/18

7:41 am-2:33 pm

1 stop5h 52m

$329

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mo 5/11

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Sa 5/16

7:55 am-6:30 pm

2 stops9h 35m

$338

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mo 5/25

6:35 am-4:50 pm

2 stops11h 15m

Panama City NW Florida Beaches

Fr 5/29

9:55 am-8:20 pm

1 stop9h 25m

$354

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Do 6/11

12:35 pm-8:10 pm

2 stops8h 35m

Panama City NW Florida Beaches

So 6/14

7:20 am-9:15 pm

2 stops12h 55m

$363

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mo 5/18

6:35 am-4:50 pm

2 stops11h 15m

Panama City NW Florida Beaches

Sa 5/23

12:40 pm-6:30 pm

1 stop4h 50m

$379

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Do 4/30

2:45 pm-9:40 pm

1 stop7h 55m

Panama City NW Florida Beaches

So 5/3

7:05 am-11:40 am

1 stop3h 35m

$407
Quickest round-trip

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sa 4/4

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Mo 4/6

4:55 pm-9:15 pm

1 stop3h 20m

$437

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fr 4/3

3:45 pm-9:20 pm

1 stop6h 35m

Panama City NW Florida Beaches

Di 4/7

7:55 am-2:20 pm

1 stop5h 25m

$437

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/19

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Best time to book a flight from Knoxville to Panama City Beach

Have a flexible travel schedule? Discover the best time to fly to Panama City Beach from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City Beach

What is the cheapest month to book a flight from Knoxville to Panama City Beach?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City Beach (average of $57). Flying from Knoxville to Panama City Beach in January is currently the most expensive (average of $281). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PA9?

Find hourly flight availability from Knoxville to Panama City Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated März 23, 2026.

One of the essential ways to save on airfare from Knoxville to Panama City Beach is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 21% on airfare.

Reviews of airlines servicing Panama City Beach

Get insights into the airlines that provide service to Panama City Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City Beach. Reviews last updated März 23, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from Knoxville to Panama City Beach to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,324 reviews

Overall

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,324 reviews
Southwest
8.0
Very good
4,324 reviews

Overall

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,319 reviews
Southwest
8.0
Very good
4,324 reviews

Overall

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,488 reviews
Southwest
8.0
Very good
4,324 reviews

Overall

8.0

Crew

8.6

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama City Beach?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Panama City Beach. On average, McGhee Tyson has 0 outbound flights to Panama City Beach per day from 4 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Panama City Beach?

    Southwest and Delta can get you from Knoxville to Panama City Beach in just under 3h 50m. Your travel time can differ by up to 3h 30m. The distance between Knoxville and Panama City Beach is about 390 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Knoxville to Panama City Beach that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City Beach.

  • Can I find deals for business class flights from Knoxville to Panama City Beach?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City Beach?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City Beach (average of $57). Flying from Knoxville to Panama City Beach in January is currently the most expensive (average of $281). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Knoxville to Panama City Beach

Discover the top 4 airlines that operate flights from Knoxville to Panama City Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated März 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$68Average$127FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$228Average$427FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$409FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$257Average$333FlexibilityNo cancel feeOn-time63%

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