$281+ Cheap flights from South Dakota to Panama City, FL (ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/4. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — ECP
Mar 4 — Mar 111
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Dakota to Panama City
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Best
Last-minute
One-way
Cheapest flights from South Dakota to Panama CityExplore the most affordable flight options available from South Dakota to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 2, 2026.
Explore the most affordable flight options available from South Dakota to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 2, 2026.
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/101:34 pm
FSD
- ECP
2 stops9h 30m
Delta
Thu 4/166:46 pm
ECP
- FSD
1 stop4h 54m
Delta
Deal found 1/31![Delta logo]()
$284
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/142:07 pm
FSD
- ECP
2 stops9h 42m
American Airlines
Thu 2/196:42 am
ECP
- FSD
1 stop5h 59m
American Airlines
Deal found 2/1![American Airlines logo]()
$463
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/142:07 pm
FSD
- ECP
2 stops9h 42m
American Airlines
Wed 2/188:20 am
ECP
- FSD
2 stops10h 50m
American Airlines
Deal found 2/1![American Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/71:23 pm
FSD
- ECP
1 stop7h 56m
American Airlines
Sat 2/146:42 am
ECP
- FSD
1 stop6h 00m
American Airlines
Deal found 2/2![American Airlines logo]()
$475
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:42 pm
FSD
- ECP
1 stop14h 59m
American Airlines
Mon 2/231:19 pm
ECP
- FSD
1 stop22h 23m
American Airlines
Deal found 2/1![American Airlines logo]()
$503
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/82:06 pm
FSD
- ECP
1 stop24h 18m
American Airlines
Fri 3/131:20 pm
ECP
- FSD
1 stop5h 50m
American Airlines
Deal found 2/1![American Airlines logo]()
$517
Best flights from South Dakota to Panama CityDiscover carefully curated flight deals from South Dakota to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 2, 2026.
Discover carefully curated flight deals from South Dakota to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 2, 2026.
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:20 am
FSD
- ECP
1 stop5h 03m
Delta
Thu 4/164:31 pm
ECP
- FSD
1 stop7h 09m
Delta
Deal found 1/31![Delta logo]()
$409
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/142:07 pm
FSD
- ECP
2 stops9h 42m
American Airlines
Wed 2/188:20 am
ECP
- FSD
2 stops10h 50m
American Airlines
Deal found 2/1![American Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:42 pm
FSD
- ECP
1 stop14h 59m
American Airlines
Mon 2/231:19 pm
ECP
- FSD
1 stop22h 23m
American Airlines
Deal found 2/1![American Airlines logo]()
$503
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/82:06 pm
FSD
- ECP
1 stop24h 18m
American Airlines
Fri 3/131:20 pm
ECP
- FSD
1 stop5h 50m
American Airlines
Deal found 2/1![American Airlines logo]()
$517
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/141:27 pm
FSD
- ECP
2 stops10h 22m
American Airlines
Thu 2/1910:36 am
ECP
- FSD
2 stops8h 34m
American Airlines
Deal found 2/1![American Airlines logo]()
$575
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:44 pm
FSD
- ECP
2 stops16h 04m
American Airlines
Mon 4/271:01 pm
ECP
- FSD
1 stop22h 41m
American Airlines
Deal found 1/31![American Airlines logo]()
$645
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:45 am
FSD
- ECP
1 stop6h 03m
American Airlines
Thu 2/191:19 pm
ECP
- FSD
1 stop5h 51m
American Airlines
Deal found 1/31![American Airlines logo]()
$695
Last-minute flights from South Dakota to Panama CityDiscover last-minute flight deals from South Dakota to Panama City. Data last updated February 2, 2026 and is based on user searches.
Discover last-minute flight deals from South Dakota to Panama City. Data last updated February 2, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/37:30 am
FSD
- ECP
2 stops8h 43m
United Airlines
Sat 2/71:10 pm
ECP
- FSD
2 stops10h 34m
United Airlines
Deal found 1/30![United Airlines logo]()
$590
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/59:00 am
FSD
- ECP
2 stops12h 59m
United Airlines
Sat 2/71:10 pm
ECP
- FSD
2 stops10h 34m
United Airlines
Deal found 2/2![United Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/71:23 pm
FSD
- ECP
1 stop7h 56m
American Airlines
Sat 2/146:42 am
ECP
- FSD
1 stop6h 00m
American Airlines
Deal found 2/2![American Airlines logo]()
$475
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/142:07 pm
FSD
- ECP
2 stops9h 42m
American Airlines
Thu 2/196:42 am
ECP
- FSD
1 stop5h 59m
American Airlines
Deal found 2/1![American Airlines logo]()
$463
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/142:07 pm
FSD
- ECP
2 stops9h 42m
American Airlines
Wed 2/188:20 am
ECP
- FSD
2 stops10h 50m
American Airlines
Deal found 2/1![American Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:42 pm
FSD
- ECP
1 stop14h 59m
American Airlines
Mon 2/231:19 pm
ECP
- FSD
1 stop22h 23m
American Airlines
Deal found 2/1![American Airlines logo]()
$503
One-way flights from South Dakota to Panama CitySearch for one-way flight options from South Dakota to Panama City. Find affordable one-way fares based on user searches. Data last updated February 2, 2026.
Search for one-way flight options from South Dakota to Panama City. Find affordable one-way fares based on user searches. Data last updated February 2, 2026.
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:45 am
FSD
- ECP
1 stop5h 59m
American Airlines
Deal found 1/31![American Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/41:00 pm
FSD
- ECP
2 stops9h 39m
Delta
Deal found 1/31![Delta logo]()
$286
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/201:26 pm
FSD
- ECP
2 stops10h 23m
American Airlines
Deal found 2/1![American Airlines logo]()
$315
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/217:43 am
FSD
- ECP
1 stop5h 31m
United Airlines
Deal found 2/1![United Airlines logo]()
$357
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:40 am
FSD
- ECP
3 stops12h 11m
United Airlines
Deal found 1/31![United Airlines logo]()
$494
Find flight deals from South Dakota to Panama City
Keep the following information in mind while searching for South Dakota to Panama City flight deals. Data was last updated February 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $284 (Delta) |
One-way from | $281 (American Airlines) |
Popular in | December |
Cheapest in | July |
Average price | $482 |
Cheapflights Fare Finder
Customize your flight search to find flights from South Dakota to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 2, 2026.
Use the filters below to find and compare flights from South Dakota to Panama City that are best for you.
Fly from
South Dakota
Fly to
Panama City
Route
Depart
Return
Price
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Fri 4/10
5:20 am-10:23 am
1 stop5h 03m
Panama City NW Florida Beaches
Thu 4/16
4:31 pm-11:40 pm
1 stop7h 09m
$409
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Sat 2/14
2:07 pm-11:49 pm
2 stops9h 42m
Panama City NW Florida Beaches
Wed 2/18
8:20 am-7:10 pm
2 stops10h 50m
$469
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Fri 2/20
7:42 pm-10:41 am
1 stop14h 59m
Panama City NW Florida Beaches
Mon 2/23
1:19 pm-11:42 am
1 stop22h 23m
$503
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Sun 3/8
2:06 pm-2:24 pm
1 stop24h 18m
Panama City NW Florida Beaches
Fri 3/13
1:20 pm-7:10 pm
1 stop5h 50m
$517
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Sat 2/14
1:27 pm-11:49 pm
2 stops10h 22m
Panama City NW Florida Beaches
Thu 2/19
10:36 am-7:10 pm
2 stops8h 34m
$575
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Thu 4/23
7:44 pm-11:48 am
2 stops16h 04m
Panama City NW Florida Beaches
Mon 4/27
1:01 pm-11:42 am
1 stop22h 41m
$645
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Sun 2/15
6:45 am-12:48 pm
1 stop6h 03m
Panama City NW Florida Beaches
Thu 2/19
1:19 pm-7:10 pm
1 stop5h 51m
$695
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Wed 3/4
6:45 am-12:44 pm
1 stop5h 59m
$281
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Wed 3/4
1:00 pm-10:39 pm
2 stops9h 39m
$286
Sioux FallsPanama City
FSD - ECP
FSDECP
Sioux Falls Joe Foss Field
Fri 3/20
1:26 pm-11:49 pm
2 stops10h 23m
$315
Showing 1-10 of 12 results
Best time to book a flight from South Dakota to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from South Dakota with our price prediction graph.
FSD-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Dakota to Panama City
USSD-ECP
FSD-ECP
What is the cheapest month to book a flight from South Dakota to Panama City, Florida?
Currently, July is the cheapest month in which you can book a flight from South Dakota to Panama City, Florida (average of $198). Flying from South Dakota to Panama City, Florida in October is currently the most expensive (average of $372). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from South Dakota to Panama City, Florida?
Related info for your journey
Find useful and relevant information for your journey from South Dakota to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for South Dakota to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from South Dakota to Panama City
Discover the top 3 airlines that operate flights from South Dakota to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$254 | Average$398 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$264 | Average$389 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$274 | Average$496 | FlexibilityNo cancel fee | On-time71% |