HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$259+ Cheap flights from Sioux Falls to Panama City, FL (FSD - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — ECP
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Sioux Falls to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Sioux Falls to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$259
(American Airlines)

Popular in

December

Cheapest in

January

Average price

$404
From Sioux Falls Joe Foss Field to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($53 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Sioux Falls to Panama City

Cheapest flights from Sioux Falls to Panama City
Explore the most affordable flight options available from Sioux Falls to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:09 pmFSD - ECP
1 stop6h 37mAmerican Airlines
Wed 12/106:33 amECP - FSD
1 stop5h 45mAmerican Airlines
Deal found 9/9$259
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:18 amFSD - ECP
2 stops10h 35mDelta
Tue 12/95:00 pmECP - FSD
1 stop6h 13mDelta
Deal found 9/10$264
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/61:32 pmFSD - ECP
1 stop8h 02mAmerican Airlines
Sat 10/116:31 amECP - FSD
1 stop6h 11mAmerican Airlines
Deal found 9/9$274
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:30 pmFSD - ECP
2 stops9h 28mDelta
Wed 12/101:32 pmECP - FSD
2 stops9h 39mDelta
Deal found 9/9$309
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/61:09 pmFSD - ECP
1 stop6h 02mAmerican Airlines
Tue 12/96:33 amECP - FSD
1 stop5h 45mAmerican Airlines
Deal found 9/9$339
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/107:16 pmFSD - ECP
2 stops16h 13mAmerican Airlines
Fri 11/145:55 pmECP - FSD
2 stops16h 32mAmerican Airlines
Deal found 9/10$341
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/178:00 amFSD - ECP
1 stop5h 03mUnited Airlines
Tue 9/236:30 amECP - FSD
2 stops10h 57mUnited Airlines
Deal found 9/10$354
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/307:00 amFSD - ECP
1 stop8h 08mAmerican Airlines
Tue 11/46:47 amECP - FSD
1 stop5h 34mAmerican Airlines
Deal found 9/8$371
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:18 amFSD - ECP
2 stops7h 29mDelta
Tue 11/255:00 pmECP - FSD
1 stop6h 11mDelta
Deal found 9/10$376

Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Sioux Falls to Panama City that are best for you.

Fly from

Sioux Falls

Fly to

Panama City

Route

Depart

Return

Price

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 12/5

1:09 pm-7:46 pm

1 stop6h 37m

Panama City NW Florida Beaches

Wed 12/10

6:33 am-12:18 pm

1 stop5h 45m

$259

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Mon 1/12

1:28 pm-8:31 pm

1 stop7h 03m

Panama City NW Florida Beaches

Sat 1/17

3:38 pm-9:02 pm

1 stop5h 24m

$259

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 12/6

5:18 am-3:53 pm

2 stops10h 35m

Panama City NW Florida Beaches

Tue 12/9

5:00 pm-11:13 pm

1 stop6h 13m

$264

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Mon 1/12

1:20 pm-10:42 pm

2 stops9h 22m

Panama City NW Florida Beaches

Sat 1/17

7:45 am-7:18 pm

2 stops11h 33m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Sioux Falls to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Sioux Falls to Panama City

What is the cheapest month to book a flight from Sioux Falls to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Sioux Falls to Panama City, Florida (average of $346). Flying from Sioux Falls to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Sioux Falls to Panama City, Florida?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Sioux Falls to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Sioux Falls to Panama City, Florida?

    American Airlines and Delta can get you from Sioux Falls to Panama City, Florida in just under 6h 37m. Your travel time can differ by up to 3h 58m. Sioux Falls and Panama City, Florida are separated by a distance of 1092 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Sioux Falls to Panama City, Florida round-trip?

    United Airlines, at $254, was found to be the cheapest airline from Sioux Falls to Panama City, Florida.Alternate airlines to your destination round-trip include Delta and American Airlines. United Airlines is currently priced 42% below the average price you’ll pay for this route.

  • Can I find deals for flights from Sioux Falls to Panama City that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Panama City.

  • Can I find deals for business class flights from Sioux Falls to Panama City?

    Yes. Cheapflights offers flight deals from Sioux Falls to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Sioux Falls to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Sioux Falls to Panama City, Florida (average of $346). Flying from Sioux Falls to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Sioux Falls to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Sioux Falls to Orlando flights
Rapid City to Orlando flights
Sioux Falls to Tampa flights
Sioux Falls to Miami flights
Sioux Falls to Fort Myers flights
Sioux Falls to Pensacola flights
Sioux Falls to Fort Lauderdale flights
Rapid City to Miami flights
Sioux Falls to Orlando Sanford Intl flights
Sioux Falls to Sarasota flights
Sioux Falls to Key West flights
Rapid City to Fort Lauderdale flights
Sioux Falls to Tallahassee flights
Sioux Falls to Jacksonville flights
Rapid City to Tampa flights
Rapid City to Fort Myers flights
Rapid City to Jacksonville flights
Sioux Falls to West Palm Beach flights
Sioux Falls to Valparaiso flights
Rapid City to Pensacola flights
Rapid City to Valparaiso flights
Sioux Falls to Daytona Beach flights
Sioux Falls to Melbourne flights
Aberdeen to Key West flights

Top 3 airlines flying from Sioux Falls to Panama City

Discover the top 3 airlines that operate flights from Sioux Falls to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$254Average$408FlexibilityNo cancel feeOn-time69%
DeltaCheapest$258Average$408FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$420FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.