HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$296+ Cheap flights from Sioux Falls to Panama City, FL (FSD - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
FSD — ECP
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Sioux Falls to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Sioux Falls to Panama City

Cheapest flights from Sioux Falls to Panama City
Explore the most affordable flight options available from Sioux Falls to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:05 amFSD - ECP
1 stop7h 42mDelta
Thu 12/252:20 pmECP - FSD
1 stop7h 47mDelta
Deal found 12/10$349
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/138:00 amFSD - ECP
2 stops8h 11mUnited Airlines
Thu 12/252:10 pmECP - FSD
1 stop7h 46mUnited Airlines
Deal found 12/10$354
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:00 amFSD - ECP
1 stop6h 21mAmerican Airlines
Thu 12/253:28 pmECP - FSD
1 stop5h 49mAmerican Airlines
Deal found 12/10$402
This Delta deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:16 amFSD - ECP
1 stop5h 01mDelta
Mon 12/294:04 pmECP - FSD
1 stop7h 36mDelta
Deal found 12/10$827
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/297:30 amFSD - ECP
1 stop5h 57mUnited Airlines
Mon 12/294:45 pmECP - FSD
2 stops24h 45mUnited Airlines
Deal found 12/10$1,141

Find flight deals from Sioux Falls to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Sioux Falls (FSD) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$279
(Delta)

Popular in

December

Cheapest in

January

Average price

$639
Provider with most accurate pricing for Sioux Falls Joe Foss Field-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Panama City NW Florida Beaches flights.
Search Deals
From Sioux Falls Joe Foss Field to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($17 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Sioux Falls to Panama City that are best for you.

Fly from

Sioux Falls

Fly to

Panama City

Route

Depart

Return

Price

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 1/21

6:00 am-5:33 pm

2 stops11h 33m

Panama City NW Florida Beaches

Thu 1/29

3:27 pm-10:04 pm

1 stop6h 37m

$296

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 1/9

7:30 am-4:12 pm

2 stops8h 42m

Panama City NW Florida Beaches

Mon 1/12

1:10 pm-11:44 pm

2 stops10h 34m

$350

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 1/9

4:17 pm-10:51 pm

2 stops6h 34m

Panama City NW Florida Beaches

Mon 1/12

5:14 pm-11:10 pm

1 stop5h 56m

$423

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/6

1:23 pm-9:19 pm

1 stop7h 56m

Panama City NW Florida Beaches

Mon 2/9

3:27 pm-10:04 pm

1 stop6h 37m

$431

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 1/28

1:40 pm-12:02 pm

2 stops22h 22m

Panama City NW Florida Beaches

Sat 1/31

6:30 am-4:37 pm

2 stops10h 07m

$467

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 1/9

1:23 pm-9:19 pm

1 stop7h 56m

Panama City NW Florida Beaches

Mon 1/12

3:27 pm-10:04 pm

1 stop6h 37m

$471

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 1/21

7:30 am-4:12 pm

2 stops8h 42m

Panama City NW Florida Beaches

Thu 1/29

4:54 pm-9:50 pm

3 stops28h 56m

$541

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Mon 12/29

5:16 am-10:17 am

1 stop5h 01m

Panama City NW Florida Beaches

Mon 12/29

4:04 pm-11:40 pm

1 stop7h 36m

$827

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Mon 12/29

5:16 am-10:17 am

1 stop5h 01m

$480

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Mon 12/29

5:12 pm-9:17 am

2 stops16h 05m

$547

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Compare providers for flights from Sioux Falls to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Sioux Falls to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Sioux Falls-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Sioux Falls-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Sioux Falls-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Sioux Falls-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Sioux Falls-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Sioux Falls to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Sioux Falls with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Sioux Falls to Panama City

What is the cheapest month to book a flight from Sioux Falls to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from Sioux Falls to Panama City, Florida (average of $198). Flying from Sioux Falls to Panama City, Florida in October is currently the most expensive (average of $372). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Sioux Falls to Panama City, Florida?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Sioux Falls to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Sioux Falls to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Sioux Falls to Panama City, Florida?

    American Airlines, United Airlines, and Delta can get you from Sioux Falls to Panama City, Florida in just under 6h 34m. Your travel time can differ by up to 4h 59m. Sioux Falls and Panama City, Florida are separated by a distance of 1092 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Sioux Falls to Panama City, Florida round-trip?

    United Airlines, at $254, was found to be the cheapest airline from Sioux Falls to Panama City, Florida.Alternate airlines to your destination round-trip include Delta and American Airlines. United Airlines is currently priced 40% below the average price you’ll pay for this route.

  • Can I find deals for flights from Sioux Falls to Panama City that include hotel bookings?

    Yes. In addition to deals on Sioux Falls to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Sioux Falls to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Sioux Falls to Panama City.

  • Can I find deals for business class flights from Sioux Falls to Panama City?

    Yes. Cheapflights offers flight deals from Sioux Falls to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Sioux Falls to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from Sioux Falls to Panama City, Florida (average of $198). Flying from Sioux Falls to Panama City, Florida in October is currently the most expensive (average of $372). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Sioux Falls to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Sioux Falls to Orlando flights
Rapid City to Orlando flights
Sioux Falls to Tampa flights
Sioux Falls to Pensacola flights
Sioux Falls to Sarasota flights
Rapid City to Fort Lauderdale flights
Sioux Falls to Fort Lauderdale flights
Sioux Falls to Fort Myers flights
Sioux Falls to Miami flights
Sioux Falls to Key West flights
Rapid City to Miami flights
Rapid City to Tampa flights
Rapid City to Fort Myers flights
Rapid City to Jacksonville flights
Sioux Falls to Orlando Sanford Intl flights
Sioux Falls to Valparaiso flights
Sioux Falls to West Palm Beach flights
Sioux Falls to Jacksonville flights
Rapid City to Pensacola flights
Sioux Falls to Daytona Beach flights
Sioux Falls to Tallahassee flights
Sioux Falls to Melbourne flights
Rapid City to Valparaiso flights
Aberdeen to Key West flights

Top 3 airlines flying from Sioux Falls to Panama City

Discover the top 3 airlines that operate flights from Sioux Falls to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$254Average$408FlexibilityNo cancel feeOn-time69%
DeltaCheapest$264Average$444FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$264Average$440FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.