$178+ Cheap flights from San Francisco to Panama City, FL (SFO - ECP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — ECP
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Panama City
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Best
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One-way
Cheapest flights from San Francisco to Panama CityExplore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:25 pm -
1 stop8h 42m
Wed 11/115:16 pm -
1 stop7h 29m
Deal found 9/18![Delta logo]()
$357
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:00 pm -
2 stops11h 45m
Tue 11/107:55 am -
1 stop9h 55m
Deal found 9/18![Southwest logo]()
$362
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:45 am -
2 stops12h 00m
Wed 10/287:40 am -
1 stop9h 30m
Deal found 9/21![Southwest logo]()
$368
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/69:25 pm -
1 stop8h 49m
Wed 11/111:34 pm -
1 stop9h 55m
Deal found 9/18![Delta logo]()
$372
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/69:25 pm -
1 stop8h 49m
Fri 11/139:33 am -
1 stop9h 43m
Deal found 9/18![Delta logo]()
$387
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:18 pm -
2 stops13h 49m
Thu 11/124:11 pm -
1 stop8h 34m
Deal found 9/18![Delta logo]()
$415
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:00 am -
1 stop9h 05m
Wed 10/218:05 am -
2 stops11h 05m
Deal found 9/18![Southwest logo]()
$417
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:00 am -
1 stop7h 27m
Wed 11/183:05 pm -
1 stop7h 56m
Deal found 9/17![United Airlines logo]()
$421
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
1 stop9h 34m
Wed 11/115:16 pm -
1 stop7h 29m
Deal found 9/18![Delta logo]()
$422
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/68:00 am -
2 stops11h 45m
Sat 12/1210:05 am -
1 stop7h 05m
Deal found 9/21![Southwest logo]()
$427
Best flights from San Francisco to Panama CityDiscover carefully curated flight deals from San Francisco to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from San Francisco to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:00 am -
1 stop9h 05m
Wed 10/218:05 am -
2 stops11h 05m
Deal found 9/18![Southwest logo]()
$417
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:00 am -
1 stop7h 27m
Wed 11/183:05 pm -
1 stop7h 56m
Deal found 9/17![United Airlines logo]()
$421
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:25 pm -
1 stop7h 49m
Sun 10/257:12 am -
1 stop7h 12m
Deal found 9/17![Delta logo]()
$481
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:00 am -
1 stop9h 13m
Tue 10/611:41 am -
1 stop8h 53m
Deal found 9/17![United Airlines logo]()
$443
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/158:00 am -
2 stops10h 35m
Sat 11/213:00 pm -
1 stop7h 00m
Deal found 9/19![Southwest logo]()
$464
This Southwest deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:20 am -
1 stop7h 10m
Sun 10/259:55 am -
1 stop10h 35m
Deal found 9/19![Southwest logo]()
$572
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:50 pm -
1 stop8h 20m
Sun 10/259:55 am -
1 stop10h 35m
Deal found 9/17![Southwest logo]()
$602
Last-minute flights from San Francisco to Panama CityDiscover last-minute flight deals from San Francisco to Panama City. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Panama City. Data last updated September 22, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:00 am -
1 stop9h 13m
Tue 10/611:41 am -
1 stop8h 53m
Deal found 9/17![United Airlines logo]()
$443
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:35 am -
2 stops10h 35m
Tue 10/610:05 am -
1 stop12h 15m
Deal found 9/17![Southwest logo]()
$490
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:00 am -
1 stop9h 05m
Wed 10/218:05 am -
2 stops11h 05m
Deal found 9/18![Southwest logo]()
$417
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/159:25 pm -
1 stop8h 44m
Mon 10/199:19 am -
1 stop10h 06m
Deal found 9/17![Delta logo]()
$446
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:40 am -
2 stops11h 35m
Mon 10/195:40 pm -
2 stops9h 00m
Deal found 9/17![Southwest logo]()
$527
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:25 pm -
1 stop7h 49m
Sun 10/257:12 am -
1 stop7h 12m
Deal found 9/17![Delta logo]()
$481
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:00 am -
1 stop7h 03m
Wed 10/289:06 am -
1 stop7h 56m
Deal found 9/21![United Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:45 am -
2 stops12h 00m
Wed 10/287:40 am -
1 stop9h 30m
Deal found 9/21![Southwest logo]()
$368
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2012:16 pm -
1 stop8h 24m
Wed 10/2812:08 pm -
2 stops8h 55m
Deal found 9/21![American Airlines logo]()
$455
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:00 am -
1 stop7h 03m
Fri 10/236:20 am -
1 stop7h 24m
Deal found 9/21![United Airlines logo]()
$502
One-way flights from San Francisco to Panama CitySearch for one-way flight options from San Francisco to Panama City. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from San Francisco to Panama City. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1610:25 pm -
1 stop7h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Delta logo]()
$178
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:59 pm -
1 stop6h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Delta logo]()
$179
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:05 am -
2 stops11h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Southwest logo]()
$184
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1611:59 pm -
1 stop9h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![United Airlines logo]()
$194
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:00 pm -
2 stops11h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$205
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:40 am -
2 stops11h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Southwest logo]()
$254
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2910:09 pm -
1 stop10h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![American Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:50 pm -
1 stop12h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$290
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:30 pm -
1 stop6h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Delta logo]()
$301
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:00 am -
1 stop9h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$309
Find flight deals from San Francisco to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $291 (American Airlines) |
One-way from | $178 (Delta) |
Popular in | December |
Cheapest in | January |
Average price | $603 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from San Francisco to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Fri 10/16
10:25 pm-8:14 am
1 stop7h 49m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$178
Quickest round-trip
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Tue 11/10
11:59 pm-8:47 am
1 stop6h 48m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$179
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Tue 11/10
5:05 am-6:15 pm
2 stops11h 10m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$184
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Fri 10/16
11:59 pm-11:06 am
1 stop9h 07m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$234
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Fri 10/16
10:45 am-10:15 pm
2 stops9h 30m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$279
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Thu 10/22
5:05 am-5:05 pm
2 stops10h 00m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$279
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Sun 10/25
5:00 am-4:18 pm
1 stop9h 18m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$309
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Mon 12/28
11:59 pm-10:46 am
1 stop8h 47m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$338
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Sun 12/27
11:18 pm-8:43 am
1 stop7h 25m
Panama City NW Florida Beaches
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$364
San FranciscoPanama City
SFO San Francisco - ECP Panama City NW Florida Beaches
SFOECP
San Francisco
Mon 10/12
6:00 am-5:05 pm
1 stop9h 05m
Panama City NW Florida Beaches
Wed 10/21
8:05 am-5:10 pm
2 stops11h 05m
$417
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Francisco-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from San Francisco with our price prediction graph.
SFO-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Panama City
What is the cheapest month to book a flight from San Francisco to Panama City, Florida?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Panama City, Florida (average of $342). Flying from San Francisco to Panama City, Florida in December is currently the most expensive (average of $1,001). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Panama City, Florida?
Airfare is below average for this route at the moment.
San Francisco to Panama City, Florida flights typically cost between $446 and $774 in January.The cheapest round-trip price found within the last 5 days was $291 on American Airlines (Jan 16-Jan 23).
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 22, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from San Francisco to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Overall
8.0
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from San Francisco to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Francisco and Panama City flights
Browse other San Francisco and Panama City flight options. Last updated on September 22, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on September 22, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from San Francisco to Panama City
Discover the top 4 airlines that operate flights from San Francisco to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$336 | Average$476 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$336 | Average$442 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$378 | Average$494 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$406 | Average$632 | FlexibilityNo cancel fee | On-time71% |