$229+ Cheap flights from San Francisco to Panama City, FL (SFO - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — ECP
May 26 — Jun 21
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Panama City
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Best
Last-minute
One-way
Cheapest flights from San Francisco to Panama CityExplore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
Explore the most affordable flight options available from San Francisco to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:55 pm
SFO
- ECP
1 stop8h 56m
Delta
Fri 6/51:50 pm
ECP
- SFO
1 stop9h 14m
Delta
Deal found 4/23![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:40 pm
SFO
- ECP
1 stop14h 05m
Southwest
Mon 9/214:25 pm
ECP
- SFO
2 stops9h 00m
Southwest
Deal found 4/23![Southwest logo]()
$366
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:07 am
SFO
- ECP
1 stop8h 19m
American Airlines
Tue 6/163:22 pm
ECP
- SFO
1 stop7h 39m
American Airlines
Deal found 4/22![American Airlines logo]()
$375
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:30 am
SFO
- ECP
2 stops8h 15m
Southwest
Sat 6/62:40 pm
ECP
- SFO
1 stop10h 50m
Southwest
Deal found 4/23![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
SFO
- ECP
2 stops11h 40m
Southwest
Tue 6/163:55 pm
ECP
- SFO
2 stops8h 30m
Southwest
Deal found 4/26![Southwest logo]()
$397
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:55 pm
SFO
- ECP
1 stop6h 35m
Delta
Sat 6/63:00 pm
ECP
- SFO
1 stop8h 04m
Delta
Deal found 4/23![Delta logo]()
$400
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:17 pm
SFO
- ECP
1 stop8h 23m
American Airlines
Sat 6/64:51 pm
ECP
- SFO
1 stop9h 57m
American Airlines
Deal found 4/23![American Airlines logo]()
$413
Best flights from San Francisco to Panama CityDiscover carefully curated flight deals from San Francisco to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
Discover carefully curated flight deals from San Francisco to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/211:55 pm
SFO
- ECP
1 stop8h 56m
Delta
Fri 6/51:50 pm
ECP
- SFO
1 stop9h 14m
Delta
Deal found 4/23![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:30 am
SFO
- ECP
2 stops8h 15m
Southwest
Sat 6/62:40 pm
ECP
- SFO
1 stop10h 50m
Southwest
Deal found 4/23![Southwest logo]()
$381
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3111:25 pm
SFO
- ECP
1 stop10h 10m
Southwest
Fri 6/512:00 pm
ECP
- SFO
1 stop9h 55m
Southwest
Deal found 4/25![Southwest logo]()
$457
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2710:59 pm
SFO
- ECP
1 stop7h 15m
Delta
Sun 7/56:41 pm
ECP
- SFO
1 stop8h 04m
Delta
Deal found 4/24![Delta logo]()
$457
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:00 am
SFO
- ECP
2 stops10h 15m
Southwest
Sun 6/75:40 am
ECP
- SFO
2 stops8h 05m
Southwest
Deal found 4/21![Southwest logo]()
$467
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:05 am
SFO
- ECP
2 stops9h 55m
Southwest
Sat 6/272:05 pm
ECP
- SFO
1 stop8h 10m
Southwest
Deal found 4/21![Southwest logo]()
$482
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:59 pm
SFO
- ECP
1 stop6h 31m
Delta
Tue 5/261:50 pm
ECP
- SFO
1 stop9h 14m
Delta
Deal found 4/25![Delta logo]()
$587
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:05 am
SFO
- ECP
2 stops11h 25m
Southwest
Sun 5/315:00 pm
ECP
- SFO
2 stops9h 50m
Southwest
Deal found 4/21![Southwest logo]()
$557
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:20 am
SFO
- ECP
2 stops10h 35m
Southwest
Fri 5/86:40 am
ECP
- SFO
2 stops9h 55m
Southwest
Deal found 4/21![Southwest logo]()
$587
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2210:55 pm
SFO
- ECP
1 stop8h 05m
Southwest
Tue 5/263:00 pm
ECP
- SFO
1 stop9h 10m
Southwest
Deal found 4/21![Southwest logo]()
$617
Last-minute flights from San Francisco to Panama CityDiscover last-minute flight deals from San Francisco to Panama City. Data last updated April 26, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Panama City. Data last updated April 26, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1512:45 am
SFO
- ECP
1 stop6h 50m
United Airlines
Sat 5/233:30 pm
ECP
- SFO
1 stop9h 26m
United Airlines
Deal found 4/23![United Airlines logo]()
$426
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/167:45 am
SFO
- ECP
2 stops10h 40m
Southwest
Sat 5/237:20 am
ECP
- SFO
1 stop11h 00m
Southwest
Deal found 4/23![Southwest logo]()
$508
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1710:28 pm
SFO
- ECP
1 stop9h 35m
American Airlines
Sun 5/246:56 pm
ECP
- SFO
1 stop7h 52m
American Airlines
Deal found 4/23![American Airlines logo]()
$487
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/175:00 am
SFO
- ECP
2 stops11h 00m
Southwest
Sun 5/244:05 pm
ECP
- SFO
1 stop9h 50m
Southwest
Deal found 4/23![Southwest logo]()
$502
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:28 pm
SFO
- ECP
1 stop10h 30m
American Airlines
Sun 5/246:56 pm
ECP
- SFO
1 stop7h 52m
American Airlines
Deal found 4/23![American Airlines logo]()
$428
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1810:55 pm
SFO
- ECP
1 stop8h 35m
Southwest
Sun 5/2412:10 pm
ECP
- SFO
2 stops13h 45m
Southwest
Deal found 4/23![Southwest logo]()
$450
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:45 am
SFO
- ECP
1 stop9h 30m
American Airlines
Fri 5/293:22 pm
ECP
- SFO
1 stop9h 59m
American Airlines
Deal found 4/26![American Airlines logo]()
$457
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:55 pm
SFO
- ECP
1 stop7h 35m
Delta
Mon 6/12:50 pm
ECP
- SFO
1 stop9h 58m
Delta
Deal found 4/23![Delta logo]()
$431
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:52 pm
SFO
- ECP
1 stop10h 16m
American Airlines
Sun 5/316:56 pm
ECP
- SFO
1 stop7h 52m
American Airlines
Deal found 4/21![American Airlines logo]()
$497
One-way flights from San Francisco to Panama CitySearch for one-way flight options from San Francisco to Panama City. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
Search for one-way flight options from San Francisco to Panama City. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/99:56 pm
SFO
- ECP
1 stop8h 24m
Delta
Deal found 4/22![Delta logo]()
$229
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:00 am
SFO
- ECP
1 stop8h 23m
Delta
Deal found 4/22![Delta logo]()
$259
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/315:50 am
SFO
- ECP
2 stops9h 40m
Southwest
Deal found 4/23![Southwest logo]()
$364
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
SFO
- ECP
2 stops27h 02m
United Airlines
Deal found 4/22![United Airlines logo]()
$428
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:00 am
SFO
- ECP
2 stops9h 43m
Delta
Deal found 4/23![Delta logo]()
$798
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:23 am
SFO
- ECP
3 stops22h 07m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$854
Find flight deals from San Francisco to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $354 (Delta) |
One-way from | $229 (Delta) |
Popular in | December |
Cheapest in | August |
Average price | $477 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
Use the filters below to find and compare flights from San Francisco to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Tue 6/2
11:55 pm-10:51 am
1 stop8h 56m
Panama City NW Florida Beaches
Fri 6/5
1:50 pm-9:04 pm
1 stop9h 14m
$354
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Tue 6/2
10:30 am-8:45 pm
2 stops8h 15m
Panama City NW Florida Beaches
Sat 6/6
2:40 pm-11:30 pm
1 stop10h 50m
$381
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Sun 5/31
11:25 pm-11:35 am
1 stop10h 10m
Panama City NW Florida Beaches
Fri 6/5
12:00 pm-7:55 pm
1 stop9h 55m
$457
Quickest round-trip
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Sat 6/27
10:59 pm-8:14 am
1 stop7h 15m
Panama City NW Florida Beaches
Sun 7/5
6:41 pm-12:45 am
1 stop8h 04m
$457
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Thu 6/4
5:00 am-5:15 pm
2 stops10h 15m
Panama City NW Florida Beaches
Sun 6/7
5:40 am-11:45 am
2 stops8h 05m
$467
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Sat 6/20
7:05 am-7:00 pm
2 stops9h 55m
Panama City NW Florida Beaches
Sat 6/27
2:05 pm-8:15 pm
1 stop8h 10m
$482
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Thu 5/28
8:05 am-9:30 pm
2 stops11h 25m
Panama City NW Florida Beaches
Sun 5/31
5:00 pm-12:50 am
2 stops9h 50m
$557
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Fri 5/22
11:59 pm-8:30 am
1 stop6h 31m
Panama City NW Florida Beaches
Tue 5/26
1:50 pm-9:04 pm
1 stop9h 14m
$587
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Tue 5/5
6:20 am-6:55 pm
2 stops10h 35m
Panama City NW Florida Beaches
Fri 5/8
6:40 am-2:35 pm
2 stops9h 55m
$587
San FranciscoPanama City
SFO - ECP
SFOECP
San Francisco
Fri 5/22
10:55 pm-9:00 am
1 stop8h 05m
Panama City NW Florida Beaches
Tue 5/26
3:00 pm-10:10 pm
1 stop9h 10m
$617
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Panama City in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Francisco-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from San Francisco with our price prediction graph.
SFO-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Panama City
What is the cheapest month to book a flight from San Francisco to Panama City, Florida?
Currently, August is the cheapest month in which you can book a flight from San Francisco to Panama City, Florida (average of $325). Flying from San Francisco to Panama City, Florida in December is currently the most expensive (average of $819). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Panama City, Florida?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 26, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from San Francisco to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Overall
8.0
Food
7.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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San Francisco and Panama City flights
Browse other San Francisco and Panama City flight options. Last updated on April 26, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on April 26, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from San Francisco to Panama City
Discover the top 4 airlines that operate flights from San Francisco to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$287 | Average$451 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$316 | Average$536 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$342 | Average$496 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$437 | Average$527 | FlexibilityNo cancel fee | On-time63% |