$178+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SFO
Jul 21 — Jul 281
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 21, 2026.
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 21, 2026.
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:56 pm
ECP
- SFO
1 stop7h 47m
American Airlines
Sat 7/2511:29 pm
SFO
- ECP
1 stop8h 05m
American Airlines
Deal found 6/21![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:30 am
ECP
- SFO
1 stop6h 55m
Southwest
Wed 9/236:50 am
SFO
- ECP
2 stops9h 55m
Southwest
Deal found 6/18![Southwest logo]()
$360
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:56 pm
ECP
- SFO
1 stop7h 47m
American Airlines
Sat 8/2911:40 pm
SFO
- ECP
1 stop8h 54m
American Airlines
Deal found 6/18![American Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:30 pm
ECP
- SFO
1 stop8h 27m
Delta
Mon 10/2611:45 pm
SFO
- ECP
1 stop6h 32m
Delta
Deal found 6/19![Delta logo]()
$381
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:30 am
ECP
- SFO
2 stops9h 10m
Southwest
Thu 10/299:15 am
SFO
- ECP
1 stop6h 30m
Southwest
Deal found 6/19![Southwest logo]()
$386
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:56 pm
ECP
- SFO
1 stop7h 47m
American Airlines
Fri 7/2411:24 am
SFO
- ECP
1 stop8h 15m
American Airlines
Deal found 6/17![American Airlines logo]()
$406
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:42 am
ECP
- SFO
1 stop9h 36m
American Airlines
Sun 9/68:45 am
SFO
- ECP
1 stop6h 48m
American Airlines
Deal found 6/21![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:47 pm
ECP
- SFO
2 stops11h 49m
Delta
Wed 9/306:00 am
SFO
- ECP
1 stop7h 31m
Delta
Deal found 6/19![Delta logo]()
$427
Best flights from Panama City to San FranciscoDiscover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 21, 2026.
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 21, 2026.
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:30 am
ECP
- SFO
1 stop6h 55m
Southwest
Wed 9/236:50 am
SFO
- ECP
2 stops9h 55m
Southwest
Deal found 6/18![Southwest logo]()
$360
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:47 pm
ECP
- SFO
1 stop10h 06m
Delta
Mon 10/2610:30 pm
SFO
- ECP
1 stop9h 45m
Delta
Deal found 6/20![Delta logo]()
$368
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:56 pm
ECP
- SFO
1 stop7h 47m
American Airlines
Sat 8/2911:40 pm
SFO
- ECP
1 stop8h 54m
American Airlines
Deal found 6/19![American Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/311:42 am
ECP
- SFO
1 stop9h 36m
American Airlines
Sun 9/68:45 am
SFO
- ECP
1 stop6h 48m
American Airlines
Deal found 6/19![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:47 pm
ECP
- SFO
1 stop8h 02m
Delta
Thu 9/245:37 pm
SFO
- ECP
2 stops12h 51m
Delta
Deal found 6/18![Delta logo]()
$438
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:55 am
ECP
- SFO
2 stops9h 30m
Southwest
Tue 7/216:00 am
SFO
- ECP
2 stops11h 45m
Southwest
Deal found 6/21![Southwest logo]()
$447
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:55 pm
ECP
- SFO
2 stops9h 35m
Southwest
Fri 7/245:10 am
SFO
- ECP
2 stops10h 05m
Southwest
Deal found 6/19![Southwest logo]()
$497
Last-minute flights from Panama City to San FranciscoDiscover last-minute flight deals from Panama City to San Francisco. Data last updated June 21, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to San Francisco. Data last updated June 21, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:56 pm
ECP
- SFO
1 stop7h 47m
American Airlines
Sat 7/2511:29 pm
SFO
- ECP
1 stop8h 05m
American Airlines
Deal found 6/20![American Airlines logo]()
$355
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:56 pm
ECP
- SFO
1 stop7h 47m
American Airlines
Fri 7/2411:24 am
SFO
- ECP
1 stop8h 15m
American Airlines
Deal found 6/17![American Airlines logo]()
$406
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2012:00 pm
ECP
- SFO
1 stop9h 55m
Southwest
Tue 7/216:00 am
SFO
- ECP
2 stops11h 45m
Southwest
Deal found 6/21![Southwest logo]()
$441
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:56 pm
ECP
- SFO
1 stop7h 47m
American Airlines
Sat 8/2911:40 pm
SFO
- ECP
1 stop8h 54m
American Airlines
Deal found 6/18![American Airlines logo]()
$368
One-way flights from Panama City to San FranciscoSearch for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated June 21, 2026.
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated June 21, 2026.
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:30 pm
ECP
- SFO
1 stop8h 27m
Delta
Deal found 6/17![Delta logo]()
$178
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/304:00 pm
ECP
- SFO
1 stop9h 05m
Southwest
Deal found 6/16![Southwest logo]()
$229
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:40 am
ECP
- SFO
1 stop10h 05m
Southwest
Deal found 6/20![Southwest logo]()
$257
This Southwest deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/202:55 pm
ECP
- SFO
1 stop7h 30m
Southwest
Deal found 6/21![Southwest logo]()
$259
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/93:42 pm
ECP
- SFO
2 stops21h 00m
Delta
Deal found 6/17![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/248:05 am
ECP
- SFO
1 stop7h 35m
Southwest
Deal found 6/18![Southwest logo]()
$286
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:40 am
ECP
- SFO
2 stops8h 05m
Southwest
Deal found 6/17![Southwest logo]()
$294
Find flight deals from Panama City to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $355 (American Airlines) |
One-way from | $178 (Delta) |
Popular in | February |
Cheapest in | January |
Average price | $456 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Wed 9/16
11:30 am-4:25 pm
1 stop6h 55m
San Francisco
Wed 9/23
6:50 am-6:45 pm
2 stops9h 55m
$360
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Sat 9/19
1:47 pm-9:53 pm
1 stop10h 06m
San Francisco
Mon 10/26
10:30 pm-10:15 am
1 stop9h 45m
$368
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Wed 7/22
6:56 pm-12:43 am
1 stop7h 47m
San Francisco
Sat 8/29
11:40 pm-10:34 am
1 stop8h 54m
$391
Quickest round-trip
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Thu 9/3
11:42 am-7:18 pm
1 stop9h 36m
San Francisco
Sun 9/6
8:45 am-5:33 pm
1 stop6h 48m
$419
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Thu 9/17
1:47 pm-7:49 pm
1 stop8h 02m
San Francisco
Thu 9/24
5:37 pm-8:28 am
2 stops12h 51m
$438
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Mon 7/20
6:55 am-2:25 pm
2 stops9h 30m
San Francisco
Tue 7/21
6:00 am-7:45 pm
2 stops11h 45m
$447
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Wed 7/15
3:55 pm-11:30 pm
2 stops9h 35m
San Francisco
Fri 7/24
5:10 am-5:15 pm
2 stops10h 05m
$497
Cheapest one-way
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Tue 9/8
5:30 pm-11:57 pm
1 stop8h 27m
$178
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Wed 9/9
5:30 pm-11:57 pm
1 stop8h 27m
$178
Panama CitySan Francisco
ECP - SFO
ECPSFO
Panama City NW Florida Beaches
Sun 8/30
1:55 pm-9:45 pm
2 stops9h 50m
$234
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Panama City to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
ECP-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Francisco
What is the cheapest month to book a flight from Panama City, Florida to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $402). Flying from Panama City, Florida to San Francisco in February is currently the most expensive (average of $991). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Panama City, Florida to San Francisco?
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated June 21, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Panama City to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Overall
7.9
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
Roseville
Cupertino
Emeryville
Newark
Watsonville
San Bruno
San Ramon
Vacaville
San Carlos
Redwood City
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Turlock
Sunnyvale
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Panama City and San Francisco flights
Browse other Panama City and San Francisco flight options. Last updated on June 21, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on June 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 21, 2026.
Top 4 airlines flying from Panama City to San Francisco
Discover the top 4 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$297 | Average$425 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$306 | Average$471 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$358 | Average$527 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$445 | Average$498 | FlexibilityNo cancel fee | On-time63% |