What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

Currently priced at $380, Delta will fly you from Panama City, Florida to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Southwest - these airlines can fly you to your destination from $417 and $492, respectively. Delta is priced at 10% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from Panama City, Florida to San Francisco one-way?

$279 is the cheapest one-way deal found within the past few days, from Southwest. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $424 and $1,271, respectively.

What is the cheapest day to fly from Panama City, Florida to San Francisco?

Travelers seeking maximum savings on their Panama City, Florida to San Francisco flight should consider departing on Saturday at noon when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Panama City, Florida to San Francisco?

Consider American Airlines, Delta or Southwest when booking your flight. These represent the most popular airlines when flying from Panama City, Florida to San Francisco.

What is the cheapest day to fly round-trip from Panama City, Florida to San Francisco?

Flights from Panama City, Florida to San Francisco are found to be more expensive on Sunday. This shouldn't discourage you from searching as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to San Francisco.

What is the cheapest month to fly from Panama City, Florida to San Francisco?

April is one of the best times of the year to fly to San Francisco from Panama City, Florida. Prices for April average $426 per person but you can even find prices for as low as $342. The most expensive prices can be found in the month of May. Opting for a April flight can save you 50% on your journey compared to booking in May

Most accurate provider : When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.

Can I find deals for business class flights from Panama City to San Francisco?

Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$279+ Flights from Panama City, FL to San Francisco

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1. Tell us where you want to go

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Cheap flight deals from Panama City to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	Expedia 3 stars
Round-trip from	$380 (Delta)
One-way from	$279 (Southwest)
Popular in	May
Cheapest in	April
Average price	$641

Provider with most accurate pricing for Panama City NW Florida Beaches-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-San Francisco flights.

Search Deals

From Panama City NW Florida Beaches to San Francisco

Search Deals

One-way flight from Panama City NW Florida Beaches to San Francisco

Search Deals

Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in May 2025

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Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 15, 2025.

Wed 7/305:05 pmECP - SFO

1 stop7h 44mDelta

Mon 8/47:30 amSFO - ECP

1 stop6h 50mDelta

Deal found 5/14

$380

Fri 6/277:19 pmECP - SFO

1 stop6h 53mAmerican Airlines

Mon 6/305:42 amSFO - ECP

1 stop9h 05mAmerican Airlines

Deal found 5/14

$417

Fri 6/275:50 amECP - SFO

2 stops9h 15mSouthwest

Mon 6/3010:45 pmSFO - ECP

1 stop8h 00mSouthwest

Deal found 5/14

$492

Fri 6/275:02 pmECP - SFO

1 stop8h 57mUnited Airlines

Sun 6/2912:30 amSFO - ECP

1 stop7h 26mUnited Airlines

Deal found 5/14

$517

Best flights from Panama City to San Francisco
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 15, 2025.

Wed 7/305:05 pmECP - SFO

1 stop7h 44mDelta

Mon 8/47:30 amSFO - ECP

1 stop6h 50mDelta

Deal found 5/14

$380

Fri 6/277:19 pmECP - SFO

1 stop6h 53mAmerican Airlines

Mon 6/305:42 amSFO - ECP

1 stop9h 05mAmerican Airlines

Deal found 5/14

$417

Fri 6/275:50 amECP - SFO

2 stops9h 15mSouthwest

Mon 6/3010:45 pmSFO - ECP

1 stop8h 00mSouthwest

Deal found 5/14

$492

Fri 6/275:02 pmECP - SFO

1 stop8h 57mUnited Airlines

Sun 6/2912:30 amSFO - ECP

1 stop7h 26mUnited Airlines

Deal found 5/14

$517

Last-minute flights from Panama City to San Francisco
Discover last-minute flight deals from Panama City to San Francisco. Data last updated May 15, 2025 and is based on user searches.

Fri 6/277:19 pmECP - SFO

1 stop6h 53mAmerican Airlines

Mon 6/305:42 amSFO - ECP

1 stop9h 05mAmerican Airlines

Deal found 5/14

$417

Fri 6/275:50 amECP - SFO

2 stops9h 15mSouthwest

Mon 6/3010:45 pmSFO - ECP

1 stop8h 00mSouthwest

Deal found 5/14

$492

Fri 6/275:02 pmECP - SFO

1 stop8h 57mUnited Airlines

Sun 6/2912:30 amSFO - ECP

1 stop7h 26mUnited Airlines

Deal found 5/14

$517

Fri 6/273:33 pmECP - SFO

2 stops9h 39mDelta

Sun 6/2912:52 amSFO - ECP

2 stops11h 25mDelta

Deal found 5/14

$2,184

One-way flights from Panama City to San Francisco
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated May 15, 2025.

Sun 11/97:30 amECP - SFO

1 stop9h 35mSouthwest

Deal found 5/14

$279

Mon 5/266:47 amECP - SFO

1 stop8h 40mAmerican Airlines

Deal found 5/14

$424

Mon 5/266:30 amECP - SFO

3 stops15h 18mUnited Airlines

Deal found 5/14

$1,271

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Wed 7/30

5:05 pm-10:49 pm

1 stop7h 44m

San Francisco

Mon 8/4

7:30 am-4:20 pm

1 stop6h 50m

$380

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Fri 6/27

7:19 pm-12:12 am

1 stop6h 53m

San Francisco

Mon 6/30

5:42 am-4:47 pm

1 stop9h 05m

$417

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Fri 6/27

5:50 am-1:05 pm

2 stops9h 15m

San Francisco

Mon 6/30

10:45 pm-8:45 am

1 stop8h 00m

$492

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Fri 6/27

5:02 pm-11:59 pm

1 stop8h 57m

San Francisco

Sun 6/29

12:30 am-9:56 am

1 stop7h 26m

$517

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Sun 11/9

7:30 am-3:05 pm

1 stop9h 35m

$279

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 5/26

6:47 am-1:27 pm

1 stop8h 40m

$424

Panama CitySan Francisco

ECP - SFO

ECPSFO

Panama City NW Florida Beaches

Mon 5/26

6:30 am-7:48 pm

3 stops15h 18m

$1,271

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/14

Compare providers for flights from Panama City to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in May.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $276). Flying from Panama City, Florida to San Francisco in June is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to SFO?

Unlike at noon, when flights are generally more expensive, you can save up to 23% on flights from Panama City, Florida to San Francisco by exploring options for tickets in the evening.

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

Southwest

8.0

Very good

4,291 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Southwest

8.0

Very good

4,291 reviews

Southwest

8.0

Very good

4,291 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Delta

8.0

Very good

7,946 reviews

Southwest

8.0

Very good

4,291 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

United Airlines

7.4

Good

8,731 reviews

Southwest

8.0

Very good

4,291 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,291 reviews

Reviews

1 / 20

10.0

Excellent

Merlyn,Feb 2025

LAX - SMF

New Terminal is neat, lost of stores and places to catch a bite.

Related info for your journey

What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?
Currently priced at $380, Delta will fly you from Panama City, Florida to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Southwest - these airlines can fly you to your destination from $417 and $492, respectively. Delta is priced at 10% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from Panama City, Florida to San Francisco one-way?
$279 is the cheapest one-way deal found within the past few days, from Southwest. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $424 and $1,271, respectively.
Can I find deals for flights from Panama City to San Francisco that include hotel bookings?
Yes. In addition to deals on Panama City to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to San Francisco.
Can I find deals for business class flights from Panama City to San Francisco?
Yes. Cheapflights offers flight deals from Panama City to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City, Florida to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to San Francisco (average of $276). Flying from Panama City, Florida to San Francisco in June is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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South San Francisco

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Manteca

Fairfield

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Hollister

Milpitas

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Campbell

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Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Panama City to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
Southwest	Cheapest$296	Average$441	FlexibilityNo cancel fee	On-time63%
Delta	Cheapest$311	Average$397	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$360	Average$396	FlexibilityNo cancel fee	On-time71%

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$279+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Panama City to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Panama City to San Francisco

Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 15, 2025.

Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.

Compare providers for flights from Panama City to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in May.

Best time to book a flight from Panama City to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to San Francisco

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

What is the cheapest time of day to fly from ECP to SFO?

Find hourly flight availability from Panama City to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 15, 2025.

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Related info for your journey

Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Panama City, Florida to San Francisco round-trip?

What are the cheapest airlines to fly from Panama City, Florida to San Francisco one-way?

Can I find deals for flights from Panama City to San Francisco that include hotel bookings?

How can I find direct flights from Panama City to San Francisco?

Can I find deals for business class flights from Panama City to San Francisco?

What is the cheapest month to book a flight from Panama City, Florida to San Francisco?

Traveling to a place near Panama City?

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Alternative routes for Panama City to San Francisco

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Top 3 airlines flying from Panama City to San Francisco

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Cheapest flights from Panama City to San Francisco
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 15, 2025.