$189+ Cheap flights from Panama City, FL to San Francisco (ECP - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SFO
Oct 31 — Nov 71
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to San Francisco
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Best
Last-minute
One-way
Cheapest flights from Panama City to San FranciscoExplore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
Explore the most affordable flight options available from Panama City to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 1, 2026.
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:07 pm -
1 stop9h 50m
Tue 10/2712:16 pm -
1 stop8h 24m
Deal found 9/27![American Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:40 am -
1 stop9h 30m
Tue 10/276:55 am -
2 stops9h 30m
Deal found 9/27![Southwest logo]()
$398
This Delta deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/139:30 am -
1 stop9h 46m
Fri 12/410:59 pm -
1 stop7h 39m
Deal found 10/1![Delta logo]()
$409
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/254:31 pm -
1 stop7h 46m
Fri 1/18:00 am -
1 stop8h 32m
Deal found 9/27![American Airlines logo]()
$464
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/233:00 pm -
2 stops10h 55m
Tue 12/299:40 pm -
2 stops10h 50m
Deal found 9/28![Southwest logo]()
$469
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:06 am -
1 stop10h 04m
Wed 11/115:00 am -
1 stop7h 28m
Deal found 9/29![United Airlines logo]()
$507
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Wed 12/234:31 pm -
1 stop8h 54m
Tue 12/299:47 am -
2 stops9h 38m
Deal found 9/28![American Airlines logo]()
$510
Best flights from Panama City to San FranciscoDiscover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
Discover carefully curated flight deals from Panama City to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 1, 2026.
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:40 am -
1 stop9h 30m
Tue 10/276:55 am -
2 stops9h 30m
Deal found 9/27![Southwest logo]()
$398
This Delta deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/139:30 am -
1 stop9h 46m
Fri 12/410:59 pm -
1 stop7h 39m
Deal found 9/28![Delta logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:06 am -
1 stop10h 04m
Wed 11/115:00 am -
1 stop7h 28m
Deal found 9/28![United Airlines logo]()
$507
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2311:10 am -
1 stop11h 00m
Tue 12/299:40 pm -
2 stops10h 50m
Deal found 9/28![Southwest logo]()
$498
Last-minute flights from Panama City to San FranciscoDiscover last-minute flight deals from Panama City to San Francisco. Data last updated October 1, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to San Francisco. Data last updated October 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:32 pm -
1 stop8h 45m
Mon 10/56:47 am -
1 stop9h 25m
Deal found 9/26![American Airlines logo]()
$681
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/134:07 pm -
1 stop9h 50m
Sat 10/176:47 am -
1 stop9h 25m
Deal found 9/28![American Airlines logo]()
$601
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:40 am -
2 stops11h 30m
Sat 10/176:20 am -
1 stop8h 45m
Deal found 9/28![Southwest logo]()
$606
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:20 pm -
1 stop7h 36m
Sun 10/1810:25 pm -
1 stop7h 49m
Deal found 9/29![Delta logo]()
$604
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:05 am -
2 stops12h 05m
Sun 10/1810:50 pm -
1 stop8h 45m
Deal found 9/29![Southwest logo]()
$609
This Southwest deal was found by Cheapflights users on 10/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:40 pm -
2 stops9h 00m
Tue 10/206:55 am -
2 stops9h 30m
Deal found 10/1![Southwest logo]()
$614
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/204:07 pm -
1 stop9h 50m
Tue 10/2712:16 pm -
1 stop8h 24m
Deal found 9/27![American Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:40 am -
1 stop9h 30m
Tue 10/276:55 am -
2 stops9h 30m
Deal found 9/27![Southwest logo]()
$398
One-way flights from Panama City to San FranciscoSearch for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
Search for one-way flight options from Panama City to San Francisco. Find affordable one-way fares based on user searches. Data last updated October 1, 2026.
This Delta deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:37 pm -
1 stop8h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Delta logo]()
$189
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:00 am -
2 stops10h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![Southwest logo]()
$210
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:37 pm -
1 stop8h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Delta logo]()
$244
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:00 am -
2 stops10h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Southwest logo]()
$249
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/202:50 pm -
1 stop7h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/29![United Airlines logo]()
$254
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:07 pm -
1 stop9h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/30![American Airlines logo]()
$304
This deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:20 am -
1 stop7h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![United Airlines logo]()
$446
This deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:06 am -
1 stop7h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![United Airlines logo]()
$519
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:00 am -
3 stops28h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$1,003
Find flight deals from Panama City to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $377 (American Airlines) |
One-way from | $189 (Delta) |
Popular in | June |
Cheapest in | January |
Average price | $464 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
Use the filters below to find and compare flights from Panama City to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Mon 11/2
5:37 pm-11:56 pm
1 stop8h 19m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$189
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Mon 11/2
7:00 am-3:10 pm
2 stops10h 10m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$210
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Sun 11/1
5:37 pm-11:56 pm
1 stop8h 19m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$244
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Sun 11/1
7:00 am-3:10 pm
2 stops10h 10m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$249
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Sat 10/31
3:05 pm-9:46 pm
1 stop8h 41m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$254
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Fri 10/16
4:07 pm-11:57 pm
1 stop9h 50m
San Francisco
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$304
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Tue 10/20
7:40 am-3:10 pm
1 stop9h 30m
San Francisco
Tue 10/27
6:55 am-6:25 pm
2 stops9h 30m
$398
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Fri 11/13
9:30 am-5:16 pm
1 stop9h 46m
San Francisco
Fri 12/4
10:59 pm-8:38 am
1 stop7h 39m
$409
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Wed 12/23
11:10 am-8:10 pm
1 stop11h 00m
San Francisco
Tue 12/29
9:40 pm-10:30 am
2 stops10h 50m
$498
Panama CitySan Francisco
ECP Panama City NW Florida Beaches - SFO San Francisco
ECPSFO
Panama City NW Florida Beaches
Tue 11/10
9:06 am-5:10 pm
1 stop10h 04m
San Francisco
Wed 11/11
5:00 am-2:28 pm
1 stop7h 28m
$507
Sorted by cheapest first
Compare providers for flights from Panama City to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to San Francisco in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Panama City with our price prediction graph.
ECP-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to San Francisco
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated October 1, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Panama City to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Comfort
8.0
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Panama City to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
Hayward
Burlingame
Rancho Cordova
San Bruno
Roseville
Redwood City
Cupertino
Newark
Fairfield
San Ramon
Manteca
Vallejo
San Carlos
Turlock
Davis
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Panama City and San Francisco flights
Browse other Panama City and San Francisco flight options. Last updated on October 1, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on October 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
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Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 1, 2026.
Top 4 airlines flying from Panama City to San Francisco
Discover the top 4 airlines that operate flights from Panama City to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$297 | Average$436 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$354 | Average$463 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$371 | Average$485 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$393 | Average$476 | FlexibilityNo cancel fee | On-time71% |