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Panama City

$160+ Cheap flights from Louisville to Panama City, FL (SDF - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/13. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — ECP
May 3 — May 101
Sun 5/3
Sun 5/10
1 adult, Economy
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Cheap flight deals from Louisville to Panama City

Cheapest flights from Louisville to Panama City
Explore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2026.

This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/29:45 am
SDF
-
ECP
1 stop4h 05m
Delta
Wed 6/106:00 am
ECP
-
SDF
1 stop3h 32m
Delta
Deal found 4/1$319
This Southwest deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/133:30 pm
SDF
-
ECP
2 stops5h 55m
Southwest
Tue 5/197:15 am
ECP
-
SDF
1 stop6h 30m
Southwest
Deal found 4/2$324
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:52 pm
SDF
-
ECP
1 stop4h 54m
American Airlines
Tue 5/194:40 pm
ECP
-
SDF
1 stop5h 50m
American Airlines
Deal found 4/1$329
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:45 am
SDF
-
ECP
1 stop6h 05m
Southwest
Mon 5/115:25 pm
ECP
-
SDF
1 stop3h 20m
Southwest
Deal found 3/31$339
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:31 am
SDF
-
ECP
2 stops9h 32m
American Airlines
Thu 5/1410:50 am
ECP
-
SDF
2 stops9h 40m
American Airlines
Deal found 3/30$349
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1610:02 am
SDF
-
ECP
1 stop3h 24m
Delta
Mon 6/226:41 pm
ECP
-
SDF
1 stop3h 41m
Delta
Deal found 3/31$353
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:30 pm
SDF
-
ECP
2 stops5h 55m
Southwest
Sat 4/257:20 am
ECP
-
SDF
2 stops9h 25m
Southwest
Deal found 3/30$355
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:41 pm
SDF
-
ECP
1 stop5h 13m
American Airlines
Sat 5/1610:50 am
ECP
-
SDF
1 stop7h 12m
American Airlines
Deal found 3/30$357
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:52 pm
SDF
-
ECP
1 stop4h 54m
American Airlines
Wed 5/610:48 am
ECP
-
SDF
2 stops9h 40m
American Airlines
Deal found 4/1$358
This Delta deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:00 am
SDF
-
ECP
1 stop3h 30m
Delta
Thu 5/286:45 pm
ECP
-
SDF
1 stop4h 40m
Delta
Deal found 3/29$359

Find flight deals from Louisville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(Delta)

One-way from

$160
(United Airlines)

Popular in

March

Cheapest in

August

Average price

$394
Provider with most accurate pricing for Louisville Intl-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Panama City NW Florida Beaches flights.
Search Deals
From Louisville Intl to Panama City NW Florida Beaches
Search Deals
One-way flight from Louisville Intl to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($85 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
Use the filters below to find and compare flights from Louisville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Sat 5/9

11:45 am-4:50 pm

1 stop6h 05m

Panama City NW Florida Beaches

Mon 5/11

5:25 pm-9:45 pm

1 stop3h 20m

$339

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Mon 5/11

9:10 am-1:12 pm

1 stop5h 02m

Panama City NW Florida Beaches

Fri 5/15

2:14 pm-10:30 pm

1 stop7h 16m

$363

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Thu 6/4

7:59 pm-11:28 pm

1 stop4h 29m

Panama City NW Florida Beaches

Fri 6/5

1:50 pm-9:19 pm

1 stop6h 29m

$363

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Fri 5/15

2:40 pm-7:50 pm

2 stops6h 10m

Panama City NW Florida Beaches

Mon 5/18

7:10 am-11:40 am

1 stop3h 30m

$368

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Thu 6/25

6:05 pm-8:10 pm

1 stop3h 05m

Panama City NW Florida Beaches

Tue 6/30

7:40 am-8:25 pm

2 stops11h 45m

$378

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Mon 4/20

6:55 am-9:05 am

1 stop3h 10m

Panama City NW Florida Beaches

Fri 4/24

9:55 am-9:00 pm

2 stops10h 05m

$378

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Sun 5/24

6:00 am-9:55 am

1 stop4h 55m

Panama City NW Florida Beaches

Fri 5/29

5:25 pm-9:45 pm

1 stop3h 20m

$387

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Sun 5/31

6:20 pm-8:30 pm

1 stop3h 10m

Panama City NW Florida Beaches

Sat 6/13

8:30 am-7:20 pm

1 stop9h 50m

$392

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Tue 5/19

7:15 am-1:17 pm

1 stop7h 02m

Panama City NW Florida Beaches

Wed 5/20

2:14 pm-10:30 pm

1 stop7h 16m

$399
Quickest round-trip

LouisvillePanama City

SDF - ECP

SDFECP

Louisville Intl

Thu 6/18

6:05 pm-8:10 pm

1 stop3h 05m

Panama City NW Florida Beaches

Mon 6/22

7:50 am-12:00 pm

1 stop3h 10m

$407

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/29

Showing 1-10 of 23 resultsSorted by cheapest first
1
2
3

Compare providers for flights from Louisville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Panama City in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Panama City

How far ahead should I book a flight from Louisville to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Louisville to Panama City. Price data was last updated on April 2, 2026.

To ensure you get the cheapest price possible for a flight from Louisville to Panama City, Florida, you should look to book at least 47 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Louisville to Panama City, Florida?

Currently, August is the cheapest month in which you can book a flight from Louisville to Panama City, Florida (average of $72). Flying from Louisville to Panama City, Florida in March is currently the most expensive (average of $123). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Louisville to Panama City, Florida?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 3, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Louisville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,344 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,344 reviews
Southwest
8.0
Very good
4,344 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,374 reviews
Southwest
8.0
Very good
4,344 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,551 reviews
Southwest
8.0
Very good
4,344 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Panama City, Florida?

    There are many flights that can get you from Louisville to Panama City, Florida in 4h 29m. Fly via Southwest, United Airlines, or Delta to get the fastest option. Louisville and Panama City, Florida are separated by a distance of 540 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Louisville to Panama City, Florida round-trip?

    According to our current data, Delta ($236), American Airlines ($256), and Southwest ($318) offers the cheapest pricing from Louisville to Panama City, Florida. Delta is currently priced 37% below the average price you’ll pay for this route.

  • Can I find deals for flights from Louisville to Panama City that include hotel bookings?

    Yes. In addition to deals on Louisville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Panama City.

  • Can I find deals for business class flights from Louisville to Panama City?

    Yes. Cheapflights offers flight deals from Louisville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Panama City, Florida?

    Currently, August is the cheapest month in which you can book a flight from Louisville to Panama City, Florida (average of $72). Flying from Louisville to Panama City, Florida in March is currently the most expensive (average of $123). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Top 3 airlines flying from Louisville to Panama City

Discover the top 3 airlines that operate flights from Louisville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$359FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$256Average$366FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$318Average$447FlexibilityNo cancel feeOn-time63%

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