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$160+ Cheap flights from Panama City, FL to Louisville (ECP - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SDF
Jun 5 — Jun 121
Fri 6/5
Fri 6/12
1 adult, Economy
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Cheap flight deals from Panama City to Louisville

Cheapest flights from Panama City to Louisville
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.

This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
ECP
-
SDF
1 stop5h 08m
Delta
Tue 5/265:47 pm
SDF
-
ECP
1 stop6h 14m
Delta
Deal found 5/1$319
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:16 pm
ECP
-
SDF
1 stop5h 11m
American Airlines
Wed 6/247:43 am
SDF
-
ECP
2 stops9h 03m
American Airlines
Deal found 5/2$324
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
ECP
-
SDF
1 stop3h 25m
Delta
Thu 5/287:59 pm
SDF
-
ECP
1 stop4h 29m
Delta
Deal found 5/1$335
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
ECP
-
SDF
1 stop3h 20m
Delta
Thu 5/283:29 pm
SDF
-
ECP
1 stop4h 40m
Delta
Deal found 5/1$351
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:41 am
ECP
-
SDF
1 stop3h 12m
Delta
Wed 5/275:47 pm
SDF
-
ECP
1 stop6h 14m
Delta
Deal found 5/1$353
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:45 pm
ECP
-
SDF
1 stop4h 40m
Delta
Wed 5/273:29 pm
SDF
-
ECP
1 stop4h 07m
Delta
Deal found 5/1$363
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:40 am
ECP
-
SDF
1 stop3h 25m
Southwest
Mon 6/2912:00 pm
SDF
-
ECP
2 stops9h 10m
Southwest
Deal found 5/5$368
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:41 am
ECP
-
SDF
1 stop3h 12m
Delta
Mon 6/17:59 pm
SDF
-
ECP
1 stop4h 29m
Delta
Deal found 5/1$369
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:00 am
ECP
-
SDF
1 stop3h 25m
Delta
Mon 6/17:59 pm
SDF
-
ECP
1 stop4h 29m
Delta
Deal found 5/1$379
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/610:30 am
ECP
-
SDF
2 stops8h 30m
Southwest
Sun 6/76:25 pm
SDF
-
ECP
1 stop3h 15m
Southwest
Deal found 5/5$384

Find flight deals from Panama City to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(Delta)

One-way from

$160
(American Airlines)

Popular in

January

Cheapest in

August

Average price

$416
Provider with most accurate pricing for Panama City NW Florida Beaches-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Louisville Intl flights.
Search Deals
From Panama City NW Florida Beaches to Louisville Intl
Search Deals
One-way flight from Panama City NW Florida Beaches to Louisville Intl
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($135 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Tue 5/26

5:29 pm-12:25 am

1 stop5h 56m

Louisville Intl

Wed 5/27

5:47 pm-11:01 pm

1 stop6h 14m

$319

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Tue 6/23

2:46 pm-7:24 pm

1 stop3h 38m

Louisville Intl

Wed 6/24

7:05 am-12:26 pm

1 stop6h 21m

$319

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Tue 6/23

4:16 pm-10:27 pm

1 stop5h 11m

Louisville Intl

Wed 6/24

7:43 am-3:46 pm

2 stops9h 03m

$324

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Tue 6/23

5:25 pm-9:40 pm

1 stop3h 15m

Louisville Intl

Mon 6/29

12:00 pm-5:15 pm

1 stop6h 15m

$363

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Mon 5/25

6:00 am-10:25 am

1 stop3h 25m

Louisville Intl

Sun 5/31

7:59 pm-11:28 pm

1 stop4h 29m

$369

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Sat 7/11

4:40 pm-9:40 pm

1 stop4h 00m

Louisville Intl

Sat 7/18

12:50 pm-7:25 pm

1 stop7h 35m

$387
Quickest round-trip

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Thu 7/30

6:20 pm-10:25 pm

1 stop3h 05m

Louisville Intl

Mon 8/3

6:05 pm-8:10 pm

1 stop3h 05m

$387

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Thu 7/9

1:25 pm-10:25 pm

2 stops8h 00m

Louisville Intl

Mon 7/13

12:00 pm-8:10 pm

2 stops9h 10m

$417

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Wed 5/20

12:05 pm-10:15 pm

2 stops9h 10m

Louisville Intl

Sun 5/24

3:50 pm-6:25 pm

1 stop3h 35m

$432
Cheapest one-way

Panama CityLouisville

ECP - SDF

ECPSDF

Panama City NW Florida Beaches

Sun 6/21

6:00 am-11:53 am

1 stop4h 53m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/1

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Panama City to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Louisville in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Louisville

What is the cheapest month to book a flight from Panama City, Florida to Louisville?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Louisville (average of $248). Flying from Panama City, Florida to Louisville in January is currently the most expensive (average of $660). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Panama City, Florida to Louisville?

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated May 6, 2026.
Read through reviews of airlines operating flights from Panama City to Louisville, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,456 reviews

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,456 reviews
Delta
7.9
Good
8,456 reviews

Boarding

8.1

Crew

8.5

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama City, Florida to Louisville?

    Delta, American Airlines, and Southwest can get you from Panama City, Florida to Louisville in just under 3h 15m. Your travel time can differ by up to 2h 41m. The distance from Panama City, Florida to Louisville is about 540 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Panama City, Florida to Louisville round-trip?

    Delta, at $236, was found to be the cheapest airline from Panama City, Florida to Louisville.. This flight start at 47% lower than the current average price 3 months from now.

  • Can I find deals for flights from Panama City to Louisville that include hotel bookings?

    Yes. In addition to deals on Panama City to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Louisville.

  • Can I find deals for business class flights from Panama City to Louisville?

    Yes. Cheapflights offers flight deals from Panama City to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Louisville?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Louisville (average of $248). Flying from Panama City, Florida to Louisville in January is currently the most expensive (average of $660). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Elizabethtown
Corydon
Jeffersonville
Bardstown

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Top airline flying from Panama City to Louisville

Discover the top airline that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$236Average$384FlexibilityNo cancel feeOn-timeN/A

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