$155+ Cheap flights from Panama City, FL to Louisville (ECP - SDF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SDF
Oct 14 — Oct 211
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Louisville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Louisville
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Cheapest flights from Panama City to LouisvilleExplore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:16 pm -
1 stop3h 35m
Mon 12/78:00 am -
1 stop5h 52m
Deal found 9/10![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:42 pm -
1 stop4h 25m
Sun 10/186:00 pm -
1 stop6h 53m
Deal found 9/10![American Airlines logo]()
$353
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:53 am -
1 stop7h 13m
Mon 12/74:35 pm -
1 stop7h 17m
Deal found 9/11![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:30 pm -
2 stops9h 19m
Mon 12/77:00 am -
1 stop7h 17m
Deal found 9/10![United Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop3h 21m
Mon 10/127:55 pm -
1 stop4h 23m
Deal found 9/10![Delta logo]()
$414
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:10 am -
2 stops9h 27m
Thu 11/266:30 am -
1 stop5h 09m
Deal found 9/9![American Airlines logo]()
$433
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:12 am -
1 stop6h 29m
Mon 10/195:57 pm -
1 stop4h 09m
Deal found 9/13![Delta logo]()
$439
Best flights from Panama City to LouisvilleDiscover carefully curated flight deals from Panama City to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
Discover carefully curated flight deals from Panama City to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:16 pm -
1 stop3h 35m
Mon 12/78:00 am -
1 stop5h 52m
Deal found 9/10![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:42 pm -
1 stop4h 25m
Sun 10/186:00 pm -
1 stop6h 53m
Deal found 9/10![American Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:30 pm -
2 stops9h 19m
Mon 12/77:00 am -
1 stop7h 17m
Deal found 9/10![United Airlines logo]()
$394
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:00 am -
2 stops7h 05m
Thu 11/266:45 am -
2 stops9h 05m
Deal found 9/9![Southwest logo]()
$439
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:53 am -
1 stop7h 13m
Mon 12/74:35 pm -
1 stop7h 17m
Deal found 9/11![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop3h 21m
Mon 10/127:55 pm -
1 stop4h 23m
Deal found 9/10![Delta logo]()
$414
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:55 am -
2 stops11h 40m
Mon 11/2312:05 pm -
2 stops9h 30m
Deal found 9/12![Southwest logo]()
$455
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:58 pm -
1 stop6h 02m
Wed 12/97:05 am -
1 stop6h 01m
Deal found 9/11![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:10 am -
2 stops9h 27m
Thu 11/266:30 am -
1 stop5h 09m
Deal found 9/9![American Airlines logo]()
$433
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:12 am -
1 stop6h 29m
Mon 10/195:57 pm -
1 stop4h 09m
Deal found 9/13![Delta logo]()
$439
Last-minute flights from Panama City to LouisvilleDiscover last-minute flight deals from Panama City to Louisville. Data last updated September 14, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Louisville. Data last updated September 14, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:29 am -
2 stops13h 04m
Wed 9/306:00 am -
1 stop7h 42m
Deal found 9/11![American Airlines logo]()
$502
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/274:33 pm -
1 stop4h 26m
Fri 10/27:55 pm -
1 stop4h 30m
Deal found 9/13![Delta logo]()
$497
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop3h 21m
Mon 10/127:55 pm -
1 stop4h 23m
Deal found 9/10![Delta logo]()
$414
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:42 pm -
1 stop4h 26m
Sun 10/116:00 pm -
1 stop6h 53m
Deal found 9/13![American Airlines logo]()
$467
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:42 pm -
1 stop4h 26m
Mon 10/128:18 pm -
1 stop4h 35m
Deal found 9/10![American Airlines logo]()
$484
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:12 am -
1 stop6h 29m
Mon 10/195:57 pm -
1 stop4h 09m
Deal found 9/13![Delta logo]()
$439
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1210:55 am -
2 stops9h 15m
Mon 10/196:15 pm -
1 stop3h 40m
Deal found 9/13![Southwest logo]()
$459
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:42 pm -
1 stop4h 25m
Sun 10/186:00 pm -
1 stop6h 53m
Deal found 9/10![American Airlines logo]()
$353
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:42 pm -
1 stop4h 35m
Thu 10/228:18 pm -
1 stop4h 35m
Deal found 9/13![American Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:40 am -
2 stops8h 30m
Thu 10/2212:10 pm -
2 stops9h 45m
Deal found 9/13![Southwest logo]()
$503
One-way flights from Panama City to LouisvilleSearch for one-way flight options from Panama City to Louisville. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
Search for one-way flight options from Panama City to Louisville. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:35 pm -
1 stop4h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Delta logo]()
$155
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:12 am -
1 stop6h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Delta logo]()
$180
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:19 am -
1 stop6h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![American Airlines logo]()
$200
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:55 am -
2 stops11h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Southwest logo]()
$211
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/303:17 pm -
1 stop5h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:30 am -
2 stops8h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Southwest logo]()
$244
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:19 pm -
1 stop4h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Delta logo]()
$249
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:00 am -
2 stops6h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Southwest logo]()
$254
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/277:00 am -
2 stops6h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Southwest logo]()
$271
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am -
1 stop3h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Delta logo]()
$327
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:29 am -
2 stops13h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$332
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:05 am -
1 stop5h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Southwest logo]()
$337
Find flight deals from Panama City to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $309 (Delta) |
One-way from | $155 (Delta) |
Popular in | December |
Cheapest in | August |
Average price | $553 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Wed 10/14
1:35 pm-7:10 pm
1 stop4h 35m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$155
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Sat 10/10
7:12 am-2:41 pm
1 stop6h 29m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$180
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Wed 11/18
7:55 am-8:35 pm
2 stops11h 40m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$211
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Wed 9/30
3:17 pm-9:43 pm
1 stop5h 26m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$239
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Wed 10/14
11:04 am-9:30 pm
2 stops9h 26m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$244
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Sat 10/3
5:30 pm-9:59 pm
1 stop3h 29m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$249
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Sat 10/3
11:00 am-6:25 pm
2 stops6h 25m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$254
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Sat 12/5
5:16 pm-9:51 pm
1 stop3h 35m
Louisville Intl
Mon 12/7
8:00 am-12:52 pm
1 stop5h 52m
$309
Quickest round-trip
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Wed 9/23
6:00 am-10:19 am
1 stop3h 19m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$327
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Sat 9/26
12:32 pm-9:31 pm
1 stop7h 59m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$337
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Panama City to Louisville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Louisville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
ECP-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated September 14, 2026.
Read through reviews of airlines operating flights from Panama City to Louisville, such as Southwest and Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Crew
8.6
Food
7.0
Comfort
8.0
Overall
8.0
Boarding
8.1
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Related info for your journey
Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Jeffersonville
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Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 14, 2026.
Panama City and Louisville flights
Browse other Panama City and Louisville flight options. Last updated on September 14, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 14, 2026.
Popular flight searches
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Top 2 airlines flying from Panama City to Louisville
Discover the top 2 airlines that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$302 | Average$456 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$302 | Average$389 | FlexibilityNo cancel fee | On-timeN/A |