$259+ Cheap flights from Panama City, FL to Louisville (ECP - SDF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — SDF
Dec 2 — Dec 91
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Louisville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Louisville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to LouisvilleExplore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/59:23 am -
1 stop3h 53m
Mon 12/75:59 pm -
1 stop3h 56m
Deal found 10/28![Delta logo]()
$281
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:05 am -
1 stop3h 51m
Fri 11/276:00 am -
1 stop3h 44m
Deal found 10/28![Delta logo]()
$301
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:25 pm -
1 stop3h 20m
Fri 12/257:20 am -
1 stop3h 10m
Deal found 10/28![Southwest logo]()
$339
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:10 pm -
1 stop3h 30m
Sun 12/65:35 pm -
1 stop4h 00m
Deal found 10/30![Southwest logo]()
$359
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:10 pm -
1 stop3h 30m
Sat 12/129:10 am -
2 stops9h 25m
Deal found 10/29![Southwest logo]()
$362
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:07 pm -
1 stop3h 54m
Mon 12/286:03 am -
1 stop3h 34m
Deal found 10/28![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/223:00 pm -
2 stops8h 30m
Mon 12/286:35 am -
1 stop3h 45m
Deal found 10/29![Southwest logo]()
$374
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:30 am -
2 stops9h 42m
Mon 12/74:35 pm -
1 stop7h 18m
Deal found 10/28![American Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:16 pm -
1 stop3h 26m
Sat 11/286:00 am -
1 stop5h 23m
Deal found 11/1![Delta logo]()
$391
Best flights from Panama City to LouisvilleDiscover carefully curated flight deals from Panama City to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
Discover carefully curated flight deals from Panama City to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:05 am -
1 stop3h 51m
Fri 11/276:00 am -
1 stop3h 44m
Deal found 10/28![Delta logo]()
$301
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:10 pm -
1 stop3h 30m
Sun 12/65:35 pm -
1 stop4h 00m
Deal found 10/30![Southwest logo]()
$359
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:30 am -
2 stops9h 42m
Mon 12/74:35 pm -
1 stop7h 18m
Deal found 10/30![American Airlines logo]()
$406
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/41:30 pm -
2 stops9h 19m
Sat 12/127:10 am -
2 stops10h 03m
Deal found 10/29![United Airlines logo]()
$411
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/59:23 am -
1 stop3h 53m
Mon 12/75:59 pm -
1 stop3h 56m
Deal found 10/31![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/223:00 pm -
2 stops8h 30m
Mon 12/286:35 am -
1 stop3h 45m
Deal found 10/29![Southwest logo]()
$374
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/224:07 pm -
1 stop3h 54m
Mon 12/286:03 am -
1 stop3h 34m
Deal found 10/29![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/41:30 pm -
2 stops9h 19m
Sun 12/67:10 am -
3 stops15h 28m
Deal found 10/30![United Airlines logo]()
$475
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1911:00 am -
2 stops9h 10m
Fri 12/257:20 am -
2 stops8h 50m
Deal found 10/28![Southwest logo]()
$457
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/295:10 pm -
1 stop3h 35m
Sun 5/26:30 am -
2 stops8h 30m
Deal found 11/1![Southwest logo]()
$472
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:25 pm -
1 stop3h 45m
Sat 12/2612:25 pm -
1 stop10h 45m
Deal found 10/28![Southwest logo]()
$486
Last-minute flights from Panama City to LouisvilleDiscover last-minute flight deals from Panama City to Louisville. Data last updated November 2, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Louisville. Data last updated November 2, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:11 pm -
1 stop5h 42m
Mon 11/1610:13 am -
1 stop5h 53m
Deal found 10/28![Delta logo]()
$517
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:10 am -
2 stops9h 03m
Mon 11/166:01 am -
1 stop6h 40m
Deal found 10/28![American Airlines logo]()
$522
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:15 am -
1 stop3h 41m
Sat 11/215:59 pm -
1 stop6h 25m
Deal found 10/31![Delta logo]()
$508
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:55 am -
2 stops11h 40m
Sat 11/2110:55 am -
2 stops11h 40m
Deal found 11/1![Southwest logo]()
$533
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:19 am -
1 stop6h 26m
Sat 11/215:02 am -
1 stop6h 32m
Deal found 10/28![American Airlines logo]()
$478
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:30 am -
2 stops10h 00m
Sat 11/217:00 am -
1 stop8h 28m
Deal found 10/28![United Airlines logo]()
$538
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:55 am -
1 stop3h 15m
Fri 11/277:00 am -
1 stop3h 35m
Deal found 10/29![Southwest logo]()
$301
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:16 pm -
1 stop3h 26m
Sat 11/286:00 am -
1 stop5h 23m
Deal found 11/1![Delta logo]()
$391
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:25 pm -
1 stop3h 45m
Sat 11/2811:25 am -
2 stops11h 10m
Deal found 11/1![Southwest logo]()
$493
One-way flights from Panama City to LouisvilleSearch for one-way flight options from Panama City to Louisville. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
Search for one-way flight options from Panama City to Louisville. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
1 stop4h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Delta logo]()
$259
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:25 am -
2 stops9h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:55 am -
1 stop3h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Southwest logo]()
$347
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:00 am -
1 stop7h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Southwest logo]()
$406
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop3h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Delta logo]()
$429
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:12 am -
1 stop4h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Delta logo]()
$449
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/289:30 am -
1 stop6h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$475
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:55 pm -
3 stops20h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$603
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/69:06 am -
3 stops28h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![United Airlines logo]()
$817
Find flight deals from Panama City to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $281 (Delta) |
One-way from | $259 (Delta) |
Popular in | December |
Cheapest in | August |
Average price | $384 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Mon 11/23
7:05 am-11:56 am
1 stop3h 51m
Louisville Intl
Fri 11/27
6:00 am-8:44 am
1 stop3h 44m
$301
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Sat 12/5
9:23 am-2:16 pm
1 stop3h 53m
Louisville Intl
Mon 12/7
5:59 pm-8:55 pm
1 stop3h 56m
$325
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Wed 11/11
12:33 pm-8:59 pm
1 stop7h 26m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$347
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Fri 12/4
4:10 pm-8:40 pm
1 stop3h 30m
Louisville Intl
Sun 12/6
5:35 pm-8:35 pm
1 stop4h 00m
$359
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Tue 12/22
4:07 pm-9:01 pm
1 stop3h 54m
Louisville Intl
Mon 12/28
6:03 am-8:37 am
1 stop3h 34m
$369
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Tue 12/22
3:00 pm-12:30 am
2 stops8h 30m
Louisville Intl
Mon 12/28
6:35 am-9:20 am
1 stop3h 45m
$374
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Sat 12/5
7:30 am-6:12 pm
2 stops9h 42m
Louisville Intl
Mon 12/7
4:35 pm-10:53 pm
1 stop7h 18m
$406
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Fri 12/4
1:30 pm-11:49 pm
2 stops9h 19m
Louisville Intl
Sat 12/12
7:10 am-4:13 pm
2 stops10h 03m
$411
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Sun 11/8
7:12 am-12:54 pm
1 stop4h 42m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$449
Quickest round-trip
Panama CityLouisville
ECP Panama City NW Florida Beaches - SDF Louisville Intl
ECPSDF
Panama City NW Florida Beaches
Mon 11/9
6:55 pm-12:10 am
1 stop4h 15m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$449
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Panama City to Louisville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Louisville in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City, Florida-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City, Florida-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
ECP-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Louisville
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated November 2, 2026.
Read through reviews of airlines operating flights from Panama City to Louisville, such as Southwest and Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentEdward,Sep 2026
MCO - BWI
Related info for your journey
Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Jeffersonville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Panama City and Louisville flights
Browse other Panama City and Louisville flight options. Last updated on November 2, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Panama City to Louisville
Discover the top 2 airlines that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$286 | Average$456 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$302 | Average$386 | FlexibilityNo cancel fee | On-timeN/A |